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Back Clinic Herbs Functional Medicine Team. A medication prepared from plants, including most of the world’s traditional remedies for disease. Most think of herbal remedies as products sold over the counter as “supplements,” such as saw palmetto extract or some ointment. However, many over-the-counter and prescription drugs are based on ingredients derived from plants, including aspirin and digoxin. Lab tests show that some herbal remedies are effective against illness. An Individual should use these drugs as carefully as prescription medicines, using caution to avoid overdose, interactions with other medications, and misuse.

Herbal medicines are one type of dietary supplement. They are sold as tablets, capsules, powders, teas, extracts, and fresh or dried plants. People use herbal medicines to maintain or improve health. Many believe that products labeled “natural” are safe to use. This is not true, as herbal medicines do not have to go through the testing that drugs do. Some herbs, such as comfrey and ephedra, can cause serious harm. In addition, certain herbs interaction with a prescription or over-the-counter medicines can work well with other medicines and be dangerous. Before using herbal medicines, first, get information from reliable sources and tell your health care provider about any herbal medicines you are taking.

Thyme To Heal The Body

Thyme To Heal The Body

Do you feel:

  • Pain, tenderness, soreness on the left side?
  • Stomach pains, burning, or aching, 1-4 hours after eating?
  • Digestive problems subside with rest and relaxation?
  • Unpredictable abdominal swelling?
  • An overall sense of bloating?

If you are experiencing any of these situations, then something might be wrong in your body, especially in the gut. Why not try to add some thyme into your food.


In the culinary world, thyme is usually associated with savory dishes that compliment the flavors. This leafy herb can be combined with chicken and can give food dishes like stuffing, sauces, stews and soups a boost in the flavor department. Even though thyme is a culinary herb, surprisingly, there is some history with this leafy herb that not everyone knows about yet. History shows that thyme was used as an embalmment by Ancient Egyptians, while Ancient Greece was using thyme as incense for their temples. History even showed that thyme has a �purifying� aroma that helped people ward off nightmares in the Middle Ages. In today’s world, thyme is well-known for its ability to enhance the flavors in the cooking world. However, it is even better known for its medicinal purifying properties for functional medicine.

Studies have found out that about approximately 1/3 of all deaths in the world are due to infectious diseases. In contrast, an alarming number of microorganisms have now become resistant to antibiotic therapy. Surprisingly though, scientists are trying to find ways to look for alternative antimicrobial therapies with thyme. Since plants have a natural defense mechanism that is built into them since they can protect themselves from harsh environmental factors. So, with thyme being a Mediterranean herb, its health properties are beneficial for the body and can dampen the effect of harmful bacterial pathogens.

Beneficial Properties Thyme Possess


Some of the beneficial properties that thyme has to offer are amazing since it has been used for medicinal usages. Thyme has a naturally occurring class of compounds known as biocides. Studies show that these compounds are known to destroy any harmful organisms like infectious bacteria, while also having powerful antimicrobial properties. In a 2010 research study, it suggested that thyme can reduce bacterial resistance to some of the common drugs, including penicillin. Some other beneficial properties that thyme presents include:

Blood Pressure

Thyme has been found to help reduce high blood pressure in individuals. Researchers in Serbia have found that wild thyme can reduce the individual�s blood pressure through animal studies. It even showed how rodents are similar to people when they are dealing with hypertension in the body. While another study found out that thyme extract can reduce a raised heart rate while also lowering the bad cholesterol. The study even showed that thyme had been used for treating a variety of various diseases that can harm the body in traditional medicine. It is even possible for thyme to be used as a substitute for salt for food.

Prevent Intestinal Infections

Studies have found out thyme can neutralize certain enteric bacteria that have been associated with some intestinal diseases. In a 2017 research study, scientists have discovered that when subjects have been in contact with the Clostridium perfringens, a harmful bacterium that can harm the intestines, can be treated with thyme. The result shows that the subjects had fewer bacterial infections in their intestines while also having fewer lesions and fewer C. perfringens related deaths.

Boost the Immune System

Even though everyone can try to live a healthy lifestyle, sometimes it is hard to get all the vitamins that the body needs to maintain itself both inside and out. Research has shown that thyme can provide the body a healthy dosage of vitamins C and A. Whenever it is the cold or flu season, thyme can be beneficial to anyone who wants to prevent the cold or flu from happening or at least dampen the symptoms. One of the beneficial properties that thyme can also do for the immune system is that it can be a good source of minerals like copper, fiber, iron, and manganese that the body does need in order to function properly.

Antimicrobial and Antifungal Properties

Thyme has antimicrobial and antifungal properties that are beneficial to the body. A Portugal study had found that thyme can provide anti-cancer activity properties to people who have colon cancer. The study even showed that thyme�s chemical constituents could identify the colon cancer cytotoxicity activities and shortening its process to become worst. Another study found in Turkey showed that wild thyme could have a positive effect on breast cancer activity. The study found that wild thyme extract can be used in novel therapeutic drugs for breast cancer treatment.

For antifungal properties, studies have found that thyme can be beneficial to combatting fungal bacteria in the body like yeast infections. Researchers in Italy have found the fungus Candida albicans is common to cause yeast infections in the mouth and vaginal area. Another study found that thyme essential oil can significantly enhance the destruction of C. Albicans in the body and preventing the fungus from spreading. The results showed that the fungal strands had a biofilm production, and only thyme oil was the only one to be the most inhibitory oil to affect biofilm production of the fungal strands.


There are many beneficial properties that thyme can posses to help not only the body but also the immune system and the gut system as well. It is truly amazing that this herb can have purifying effects on the body and even enhance the flavors of food dishes.�Since more people are using thyme in their culinary dishes, it is no wonder that thyme is a truly, magical herb that can help the body achieve an overall sense of health and wellness. Some products that can be beneficial to the body, including the immune system, by providing support to the intestines for greater stability, bioavailability, and digestive comfort.

The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.


Laboratories, Medical Oncology Research. �Effects of Thymus Serpyllum Extract on Cell Proliferation, Apoptosis and Epigenetic Events in Human Breast Cancer Cells.� Taylor & Francis, 19 Nov. 2012,

Team, Biotics Education. �Thyme for Gut Health.� Biotics Research Blog, 2017,

Alamgeer, et al. �Pharmacological Evaluation of Antihypertensive Effect of Aerial Parts of Thymus Linearis Benth.� Acta Poloniae Pharmaceutica, U.S. National Library of Medicine, 2014,

Fanous, Summer. �9 Health Benefits of Thyme.� Healthline, 5 May, 2016,

Felman, Adam. �What Are the Benefits of Thyme?� MedicalNewsToday, 23 Aug. 2018,

Gordo, Joana, et al. �Thymus Mastichina: Chemical Constituents and Their Anti-Cancer Activity.� Natural Product Communications, U.S. National Library of Medicine, Nov. 2012,

Khan, Mohd S A, et al. �Sub-MICs of Carum Copticum and Thymus Vulgaris Influence Virulence Factors and Biofilm Formation in Candida Spp.� BMC Complementary and Alternative Medicine, BioMed Central, 15 Sept. 2014,

Kim, Gil-Hah, et al. �Chemical Composition, Larvicidal Action, and Adult Repellency of Thymus Magnus Against Aedes Albopictus.� Journal of the American Mosquito Control Association, The American Mosquito Control Association, 1 Sept. 2012,

Palaniappan, Kavitha, and Richard A. Holley. �Use of Natural Antimicrobials to Increase Antibiotic Susceptibility of Drug Resistant Bacteria.� International Journal of Food Microbiology, Elsevier, 13 Apr. 2010,

Team, WHO. �The Top 10 Causes of Death.� World Health Organization, World Health Organization, 24 May 2018,

Wong, Cathy. �The Use of Thyme in Alternative Medicine.� Verywell Health, Verywell Health, 28 Apr. 2020,

Yin, D., Du, E., Yuan, J.�et al.�Supplemental thymol and carvacrol increases ileum�Lactobacillus�population and reduces effect of necrotic enteritis caused by�Clostridium perfringes�in chickens.�Sci Rep7,�7334 (2017).

Modern Integrative Wellness- Esse Quam Videri

The University offers a wide variety of medical professions for functional and integrative medicine. Their goal is to inform individuals who want to make a difference in the functional medical fields with knowledgeable information that they can provide.

Astragalus and The Immune System

Astragalus and The Immune System

Do you feel:

  • Dizziness when standing up quickly?
  • A slow start in the morning?
  • Edema and swelling in ankles and wrist?
  • Muscle cramping?
  • Tired or sluggish?

If you are experiencing any of these situations, then there might be some dysfunction in your body�s system, including the immune system. Why not try the Chinese herb, astragalus to help alleviate the symptoms.


In traditional Chinese medicine, the herb astragalus has been used for thousands of years and has been known to strengthen chi or qi life force in the body. This herb has been known to be typically employed in conditions that are related to general weakness in the body like fatigue, anemia, a poor appetite, cardiovascular diseases, and other conditions that can weaken the body. Surprisingly though, astragalus can be used to optimize kidney health and, with the combination of ginseng and echinacea, can boost up the body’s immune system. There is a variety of astragalus that are native to Northeast Asia, and its roots need to be dried and powdered to be transformed to be consumed as a capsule or as a tea.

Astragalus Beneficial Properties

Studies have found that astragalus�s beneficial pharmacological effects might contain phytochemical components, which include a host of saponins polysaccharides and flavonoids that the body’s immune system needs to function correctly. Another study found that astragalus contains about twenty trace minerals that are highly important for the body. With astragalus extract, it has immune-modulating properties in vivo and in vitro in both animals and humans, and research shows that the herb stimulates and influences on the immune response cytokines while also leaving the inflammatory cytokines unaffected.

Some of the beneficial properties that astragalus can have on the body are still being researched; however, this Chinese herb can help the body to function correctly and are effective.

Improving the Immune System


Studies have shown that astragalus contains some beneficial plant compounds that may enhance the body’s immune system. Studies show that the primary role for the immune system is that it helps protect the body from foreign pathogens like harmful bacteria and viruses that can cause a person to be ill. Research has found out that there is some evidence that astragalus can increase the body�s production of white blood cells, which will help prevent illnesses from entering the body. In other research studies, it has been found that astragalus root has been known to help the body kill bacteria and viruses caused by infections. Even though the research may be limited, there are still studies that show that astragalus can fight off viral infections like the common cold and liver infections in the human body.

Improving the Heart Function

Research shows that astragalus may be able to improve heart function by widening the blood vessels and increasing the amount of blood that is being pumped from the heart. In a clinical research study, it showed that patients were given at least 2.25 grams of astragalus for two weeks and have experienced a more significant improvement in their heart function. In another study, it shows that astragalus may help reduce the symptoms of myocarditis, which is an inflammatory condition in the heart.

Improving Kidney Function

Astragalus can help support kidney health in the body by improving the blood flow to the kidneys and measuring the protein in the urine. A study has shown that proteinuria is a condition where there is an abnormal amount of protein that is found in urine, and it can be a sign that the kidneys are not functioning normally or may be damaged. Surprisingly, there was another study that showed that astragalus could improve proteinuria symptoms in individuals that have kidney disease. Studies have even found that astragalus may also help prevent infections for anyone who has a reduce kidney function and reducing the risk of a kidney disorder known as nephrotic syndrome.


Astragalus is a unique herb that can help the body’s immune system to function correctly. Even though there is a limited amount of research on this herb, but the beneficial properties it provides in the body are truly amazing. Astragalus can be consumed by capsules or even be brewed as a tea, so that way, people can enjoy the beneficial properties and that their body is performing excellently in health and wellness. Some products offer support to the body’s immune system and help target the amino acids that are intended to support the intestines while offering more support to the metabolic system.

The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.


Block, Keith I, and Mark N Mead. �Immune System Effects of Echinacea, Ginseng, and Astragalus: a Review.� Integrative Cancer Therapies, U.S. National Library of Medicine, Sept. 2003,

Fu, Juan, et al. �Review of the Botanical Characteristics, Phytochemistry, and Pharmacology of Astragalus Membranaceus (Huangqi).� Phytotherapy Research: PTR, U.S. National Library of Medicine, Sept. 2014,

Gao, Xing-hua, et al. �Saponin Fraction from Astragalus Membranaceus Roots Protects Mice against Polymicrobial Sepsis Induced by Cecal Ligation and Puncture by Inhibiting Inflammation and Upregulating Protein C Pathway.� Journal of Natural Medicines, U.S. National Library of Medicine, Oct. 2009,

Meixner, Makayla. �Astragalus: An Ancient Root With Health Benefits.� Healthline, 31 Oct. 2018,

Nalbantsoy, Ay?e, et al. �Evaluation of the Immunomodulatory Properties in Mice and in Vitro Anti-Inflammatory Activity of Cycloartane Type Saponins from Astragalus Species.� Journal of Ethnopharmacology, U.S. National Library of Medicine, 31 Jan. 2012,

Peng, T Q, et al. �Effect and Mechanism of Astragalus Membranaceus on Coxsackie B3 Virus RNA in Mice.� Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine, U.S. National Library of Medicine, Nov. 1994,

Piao, Yuan-lin, and Xiao-chun Liang. �Astragalus Membranaceus Injection Combined with Conventional Treatment for Viral Myocarditis: a Systematic Review of Randomized Controlled Trials.� Chinese Journal of Integrative Medicine, U.S. National Library of Medicine, Oct. 2014,

Team, DFH. �Astragalus: Funny Name Serious Results.� Designs for Health, 9 Oct. 2018,

Team, NCBI. �Astragalus Membranaceus. Monograph.� Alternative Medicine Review: a Journal of Clinical Therapeutic, U.S. National Library of Medicine, Feb. 2003,

Wang, Deqing, et al. �Study of the Effects of Total Flavonoids of Astragalus on Atherosclerosis Formation and Potential Mechanisms.� Oxidative Medicine and Cellular Longevity, Hindawi Publishing Corporation, 2012,

Wu, Hong Mei, et al. �Interventions for Preventing Infection in Nephrotic Syndrome.� The Cochrane Database of Systematic Reviews, John Wiley & Sons, Ltd, 18 Apr. 2012,

Yang, Qing-you, et al. �Effects of Astragalus on Cardiac Function and Serum Tumor Necrosis Factor-Alpha Level in Patients with Chronic Heart Failure.� Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine, U.S. National Library of Medicine, July 2010,

Zhang, Hong Wei, et al. �Astragalus (a Traditional Chinese Medicine) for Treating Chronic Kidney Disease.� The Cochrane Database of Systematic Reviews, U.S. National Library of Medicine, 22 Oct. 2014,

Modern Integrative Wellness- Esse Quam Videri

The University offers a wide variety of medical professions for functional and integrative medicine. Their goal is to inform individuals who want to make a difference in the functional medical fields with knowledgeable information that they can provide.

The Wonderful Benefits of Sage

The Wonderful Benefits of Sage

Do you feel:

  • Inflammation in the joint and the mouth?
  • Your glucose levels rising a little bit?
  • Unpredictable abdominal swelling?
  • Hormone imbalances?
  • Weight gain?

If you are experiencing any of these situations, then why not try adding some sage into your dishes.


Throughout the world in the culinary arts and the health world, traditional foods and tasty recipes always required certain spices and herbs that will boost the flavors of the dishes that a person is creating to be consumed. Like for example, sweet potatoes pairing with cinnamon, it is like tasting heaven. Any meat products or vegetables thrive when a person is seasoning these products with many herbs and spices. The herb salvia officinalis or sage fills the air with its aroma and enhances the flavor of many foods.


Like any other herbs, sage is a powerhouse in the nutritional food world. Studies show how a large quantity of sage can have a significant amount of micronutrients when it is seasoning poultry and different kinds of animal meat products. What is a surprise of this herb is that it is not just to make poultry mouthwatering, but sage can be used as an essential oil as well. Research shows that sage essential oil can exhibit antimicrobial effects against any harmful bacteria that enter the body. It even has antioxidant properties to protect the body against lipid peroxidation.

Sage Benefits

There are many benefits that sage can provide the body and can protect the body�s cells from free radicals that can damage the body and impaired not only the immunity but can also develop chronic diseases. Some of the beneficial properties that sage can provide are:

Treating Alzheimer�s

Sage can have a positive impact on a person�s cognitive skills and can protect the brain from neurological disorders, like Alzheimer�s disease. In a recent study, it showed how sage is a cognitive- enhancing agent to increase the brain’s function. Since sage has been used in traditional remedies to treat a wide range of problems in the digestive tract and body circulation. It can enhance the head and brain function by improving a person’s memory, quicken their senses, and delay any age-associated cognitive diseases.

Lowers Glucose and Cholesterol

Sage can help lower the body�s glucose and cholesterol levels. One study showed how 40 participants with diabetes and high cholesterol took sage leaf extract for at least three months, and the results were astounding. The results showed that the participants had low levels of glucose and low levels of cholesterol.

Another study found that people who have type 2 diabetes use sage to lower their blood sugar levels to prevent DKA (diabetic ketoacidosis). The study concluded that sage could be beneficial for anyone that has diabetes to reduce glucose levels. By consuming sage into a person�s diet is marvelous because of the properties that it provides for anyone who may have a higher glucose level or even a high level of cholesterol.

Reduces Inflammation

There is more evidence that sage has certain compounds that has anti-inflammatory actions. Studies show that sage has beneficial anti-inflammatory effects for inflammation in the connective tissues of the gums in the mouth. Sage’s anti-inflammatory properties have been used in a dentist’s office since it is used as an oral antiseptic to dull the pain of gingival fibroblasts.

Ease Menopause Symptoms

When the body experiences a natural decline of hormones, both males and females can experience menopause, and this can cause a wide range of unpleasant symptoms for anybody. From hot flashes, excessive sweating, low levels of testosterone and estrogen, to mood swings, and even being irritable. Studies have shown that common sage has been used as a traditional medicine to reduce menopause symptoms from the body. There are even more studies showing that the sage has estrogen-like properties that will allow the compounds to bind to neurological receptors in the brain to improve the body�s cognitive memory and function.


There are many usages for sage as this herb is a powerhouse when it comes to everyday products. Sage can even be used to purify the toxins that are in the air and seasoned poultry and different kinds of meats. With its anti-inflammatory properties, it can dampen inflammation and prevent it from turning into chronic inflammation in the body. So by adding sage into dishes can not only boost the dishes that need sage in the recipes but can also provide beneficial properties to the body. Some products can help support the immune system and are designed for more excellent stability, bioavailability, and digestive comfort.

The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.


Bozin, Biljana, et al. �Antimicrobial and Antioxidant Properties of Rosemary and Sage (Rosmarinus Officinalis L. and Salvia Officinalis L., Lamiaceae) Essential Oils.� Journal of Agricultural and Food Chemistry, U.S. National Library of Medicine, 19 Sept. 2007,

Fawzi, Muntaha, et al. �Anti-Inflammatory Effect of Sage (Salvia Officinalis) Extracts ABSTRACT on Oral Health.� Iraqi Dental Journal, 2017,

Kargozar, Rahele, et al. �A Review of Effective Herbal Medicines in Controlling Menopausal Symptoms.� Electronic Physician, Electronic Physician, 25 Nov. 2017,

Lopresti, Adrian L. �Salvia (Sage): A Review of Its Potential Cognitive-Enhancing and Protective Effects.� Drugs in R&D, Springer International Publishing, Mar. 2017,

Rahte, Sinikka, et al. �Salvia Officinalis for Hot Flushes: towards Determination of Mechanism of Activity and Active Principles.� Planta Medica, U.S. National Library of Medicine, June 2013,

Team, DFH. �Sage Is All the Rage (or at Least It Should Be!).� Designs for Health, 23 Dec. 2019,

Ware, Megan. �Sage: Health Benefits, Facts, and Research.� Medical News Today, MediLexicon International, 10 Jan. 2018,

Modern Integrative and Functional Wellness- Esse Quam Videri

By informing individuals about how the National University of Health Sciences provides knowledge for future generations who want to make a difference in the world. The University offers a wide variety of medical professions for functional and integrative medicine.



Tis The Season For These Botanical Herbs

Tis The Season For These Botanical Herbs

Do you feel:

  • Unpredictable abdominal swelling?
  • Hormone imbalance?
  • Occasional stress?
  • Inflammation in the gut?
  • Weight gain?

If you are experiencing any of these situations, then why not try these botanical herbs in your food dish.

The holiday season brings out the joy out of people with holiday traditions and its unique, universal foods, drinks, seasonal herbs, and spices to the table. The colder seasons are where everyone in the U.S. indulges in hearty soups, pumpkin spice products, root vegetables, and turkey leftovers. Many holiday menu items will incorporate sweet and savory herbs and spices in their food dishes. What people do not realize is that even though these herbs and spices enhance the flavors of the food, they also provide a plethora of health benefits for the body. So using these herbs and spices in the kitchen can help increase the person’s chances to receive their beneficial properties, hence “the more, the merrier.”


Throughout the centuries, medicinal plants have been traditionally used by a variety of cultures. Some of nature’s most potent herbs are most used in culinary dishes, while also providing the beneficial properties to the human body; they are rosemary, sage, and clove.


Being commonly used as a condiment and a food preservative, rosemary is a native herb in the Mediterranean region. A review did an animal study of in vivo and in vitro that showed that rosemary had demonstrated similar beneficial effects to any medications that are for a variety of physiological disorders. Some of the physiological disorders include:

  • Lead hepato-nephrotoxicity
  • Stress
  • Anxiety
  • Bodyweight and dyslipidemia
  • Pain
  • Cerebral ischemia

Another review was looking at how rosemary has antimicrobial and antioxidant properties and that its abundance in isoprenoid quinones. The review stated that rosemary could �act as chain terminators for free radicals and as chelators for ROS (reactive oxygen species.)” The antioxidative properties in rosemary have about the majority of phenolic diterpenes; like carnosic acid and carnosol, that are responsible for about 90% of this herb. Since it inhibits lipid peroxidation, scavenge radicals, and helps reduce cytochrome c by activating the redox-dependent signaling pathways in the body.

With carnosic acid, it has been shown to provide superior antimicrobial actions to other significant constituents that are found in rosemary. Furthermore, there have been studies shown that rosemary has antibacterial effectiveness against resistant bacteria in the body.


Sage is another herb that is native to the Mediterranean and Middle East regions and has been used in traditional folk medicine to treat a variety of disorders in the body. There is recent research that has suggested that sage can possess a wide range of beneficial properties for the body due to the presence of carnosic acid and carnosol in this herb. Another study showed that sage contains high contents of glycosidic flavones that provide functional inhibitory capacity against xanthine oxidase activity in the body. Some of the beneficial properties include:

  • Anti-inflammatory
  • Antinociceptive
  • Antibacterial
  • Hypoglycemic
  • Antioxidative

There is further research that demonstrates how sage has powerful cognitive enhancing and neuroprotective properties. Studies show that patients with Alzheimer�s disease took a 4-month supplementation of sage, and the results are remarkable. Alzheimer patients experienced significant improvements in their cognitive function and mood enhancements. In another study, sage extract can help reduce the severity of physical and psychological systems that are experienced in premenstrual syndrome in the body. A recent article showed how freshly harvested sage leaves can become a potent modulator for neuroreceptor pathways that involves serotonin transporters that may help normalize thermoregulation and mental impairment for menopausal women.

Surprisingly though, both rosemary and sage have been proven and shown that they can help improve gabaergic pathways in the brain and can help decrease the neuronal activities that are associated with anxiety disorders. Studies show that rosemary and sage extracts have hepatoprotective and antioxidative roles that can increase catalase and glutathione levels and decrease lipid peroxidation in the body.


Clove buds were initially found in east Indonesia, and it plays a role as the herb has a potent antimicrobial and antioxidative botanical. Research shows that clove oil possesses a bactericidal effect against pathogenic species that can harm the body. Earlier this year, a research study found out that clove oil extract can enhance anti-inflammatory activity by reducing myeloperoxidase activity in human neutrophils significantly. This herb can help reduce ROS and a variety of other inflammatory mediators that can promote significant damage to the body at the site of inflammation.


So for the holidays, adding these three powerful herbs to the next holiday feast are not just there to help enhance the flavors of the dishes, but they are beneficial to the body. Since they provide anti-inflammatory properties to the body by decreasing the inflammatory responses. So for the colder seasons, add that extra dash of herbs into the dish recipe will make anyone’s day merry. Some products are specialized in countering the metabolic effects of temporary stress and can support the body.

The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.


Chniguir, Amina, et al. �Syzygium Aromaticum Aqueous Extract Inhibits Human Neutrophils Myeloperoxidase and Protects Mice from LPS-Induced Lung Inflammation.� Pharmaceutical Biology, Taylor & Francis, Dec. 2019,!po=2.63158.

Choukairi, Zineb, et al. �Effect of Salvia Officinalis L. and Rosmarinus Officinalis L. Leaves Extracts on Anxiety and Neural Activity.� Bioinformation, Biomedical Informatics, 15 Mar. 2019,

de Oliveira, Jonatas Rafael, et al. �Rosmarinus Officinalis L. (Rosemary) as Therapeutic and Prophylactic Agent.� Journal of Biomedical Science, BioMed Central, 9 Jan. 2019,

Lopresti, Adrian L. �Salvia (Sage): A Review of Its Potential Cognitive-Enhancing and Protective Effects.� Drugs in R&D, Springer International Publishing, Mar. 2017,

Nieto, Gema, et al. �Antioxidant and Antimicrobial Properties of Rosemary (Rosmarinus Officinalis, L.): A Review.� Medicines (Basel, Switzerland), MDPI, 4 Sept. 2018,

Pavi?, Valentina, et al. �Extraction of Carnosic Acid and Carnosol from Sage (Salvia Officinalis L.) Leaves by Supercritical Fluid Extraction and Their Antioxidant and Antibacterial Activity.� Plants (Basel, Switzerland), MDPI, 9 Jan. 2019,

Pereira, Ol�via R, et al. �Salvia Elegans, Salvia Greggii and Salvia Officinalis Decoctions: Antioxidant Activities and Inhibition of Carbohydrate and Lipid Metabolic Enzymes.� Molecules (Basel, Switzerland), MDPI, 1 Dec. 2018,

Team, DFH. �Spice Up the Holidays with Medicinal Botanicals.� Designs for Health, 25 Nov. 2019,

Tober, Carsten, and Roland Schoop. �Modulation of Neurological Pathways by Salvia Officinalis and Its Dependence on Manufacturing Process and Plant Parts Used.� BMC Complementary and Alternative Medicine, BioMed Central, 13 June 2019,






Chamomile and Inflammation

Chamomile and Inflammation

Do you feel:

  • Anxious or cannot focus on tasks?
  • Do digestive problems subside with rest or relaxation?
  • Stomach pains, burning, or aching 1-4 hours after eating?
  • Redden skin?
  • Nausea or vomiting?

If you are experiencing any of these situations, then you might be experiencing some digestive stress. Try some chamomile to reduce that stress and anxious mind.

Chamomile and its products are well-known for encouraging a healthy state of mind and for enhancing amazing sleep quality for anyone who takes this herb. This white and yellow blossom, however, has several impressive health benefits that are beneficial with anyone that’s feeling anxious in their daily, hectic lives and can provide other benefits for the body that has some ailments.

What is Chamomile?

Chamomile is an ancient medicinal plant by the Asteraceae family and is frequently known as the “earth apple on the ground” due to the apple-like fragrance it produces. Its blossoms have unique properties that could boost a person�s wellbeing and supplying beneficial nutrients that are remarkable for the body to relax and feel calm. This plant has existed for centuries and is native to eastern and southern Europe. Tons of research have shown that chamomile has been used in herbal remedies in ancient times during the Roman era, Greek era and Egypt era. The plant contains a thin spindle-shaped stem that produces tiny flower blossoms that resemble a daisy.

Chamomile Benefits


The chemicals of chamomile can serve as antioxidants in the human body and can prevent flare-ups from occurring. Because of this, when an individual is consuming chamomile goods; the health properties might help prevent the common cold, intestinal disorders from the gut, inflammation and many more body ailments that can affect the human body from functioning properly. There are two varieties of chamomile that have amazing properties that have been used for natural remedies are the German chamomile and the Roman chamomile.

  • German Chamomile: This type of chamomile is popular around the world and native to southern and eastern Europe. Studies have shown that people would take chamomile by the mouth to relieve ailments caused by environmental factors. There are some people that will even apply chamomile on their skin as an ointment. There is some scientific evidence that using German chamomile as an oral rinse could be helpful for cancer patients that have mucositis, which is inflammation and ulceration of the mucosal membrane lining in the digestive tract caused from chemotherapy and radiotherapy.
  • Roman Chamomile: This type of chamomile provides the same benefits as German Chamomile as it relieves the same ailments that environmental factors caused but also provides a bit more help to the body. Roman chamomile has hypnotic properties that help a person relax and falls asleep faster. There have been studies that this herb offered hypnotic effects to animals and when consumed, it decreased the amount of time for them to fall asleep.

The benefits that the chamomile plant provides are that it promotes the body to relax and other benefits that are essential to the body. When it is used as an essential oil for aromatherapy, the patient can feel less anxious when they breathe in the vapors and finally let their anxious mind relax.

Reducing Pain

The anti-inflammatory effect that both the essential oil and the chamomile flower itself can aid the body by reducing the pain that it has encountered. Since the chamomile plant has been used for hundreds, people have been using this plant to help reduce pain from inflammatory-related symptoms in the body they might be experiencing.

Studies have shown that people who consume herbal tea for their joint inflammation have shown an improvement especially in the knees and lower back. The antioxidant and anti-inflammatory properties that this herbal tea produces polyphenols that affect systemic inflammation and joint function in the body. Another study shows that patients with knee osteoarthritis used chamomile oil to decrease the stiffness in their joints and provide some beneficial effects on their physical function.

Heals and Promotes Skin Health

For anyone that has eczema and uses topical creams to reduce the redness, they might want to try using chamomile essential oil. The benefits of using chamomile essential oil are that it can help reduce irritated skin. A person can mix the chamomile essential oil with a carrier oil or lotion and apply it to their skin as the anti-inflammatory and antibacterial properties can calm down the red, dry, irritated skin while also decreasing breakouts from happening.

In some instances, there have been statements that chamomile is more effected than hydrocortisone lotion for skin lesions. Researchers found in a 2010 study, that German chamomile oil has been used to alleviate atopic dermatitis, which is a chronic skin disorder, by containing three major sesquiterpene constituents (azulene, bisabolol, and farnesene) by healing the skin gradually.

Improving Digestion

Another widespread use for chamomile, especially when it is brewed in a tea, is reducing unwanted symptoms that are associated with poor digestion in the digestive system. With chamomile tea, it can soothe an upset stomach, cramping, flatulence, and diarrhea. The therapeutic compounds that are found in chamomile can act as a digestive relaxant.

Improves Sleep and Relaxation

When it is brewed into a tea, chamomile can promote a person�s frame in mind and can enhance their sleep quality to provide them the necessary 8 hours of sleep. Research shows that individuals who drink chamomile tea before going to bed, have a better night’s sleep and relaxing a bit more. Apigenin provides a stimulant effect from chamomile tea and is bind with the benzodiazepine receptors in the brain, providing benefits that can help reduce stress from the body while also promoting a good night�s sleep.

In a 2017 study, the research shows that adults over the age of 60, consumed chamomile tea before they go to bed. The results showed that their sleep quality improved by reducing sleep complications like sleep apnea and the consumption of using sleep medication while improving their moods drastically over time.

Boosting Mental Wellness

Using chamomile products can benefit a person�s wellness. Since chamomile has beneficial properties to make the body relax, it can also help reduce the sensation of depression and anxiety in a person when it is consumed. Studies have stated that long-term chamomile intake is safe and may considerably reduce the effects of moderate to severe GAD symptoms in the body. Even using the oil for aromatherapy can be considered as an alternative for treatments for patients.


Thus chamomile is an effective and secured plant that has been used by individuals who have been experiencing a number of symptoms. Since chamomile is excellent for reducing pain, have better skin, improve mental health and provide many beneficial factors. When it is used in aromatherapy or consumed into the body, chamomile is a natural cure for a nervous mind. Some products combined with chamomile are designed to offer support to the gastrointestinal tract and make sure that sugar metabolism is functioning properly.

The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.


Abdullahzadeh, Mehrdad, et al. �Investigation Effect of Oral Chamomilla on Sleep Quality in Elderly People in Isfahan: A Randomized Control Trial.� Journal of Education and Health Promotion, Medknow Publications & Media Pvt Ltd, 5 June 2017,

Charousaei, Firuzeh, et al. �Using Chamomile Solution or a 1% Topical Hydrocortisone Ointment in the Management of Peristomal Skin Lesions in Colostomy Patients: Results of a Controlled Clinical Study.� Ostomy/Wound Management, U.S. National Library of Medicine, May 2011,

Christiansen, Sherry. �The Health Benefits of Roman Chamomile.� Verywell Health, Verywell Health, 14 Jan. 2019,

Drummond, Elaine M, et al. �An in Vivo Study Examining the Antiinflammatory Effects of Chamomile, Meadowsweet, and Willow Bark in a Novel Functional Beverage.� Journal of Dietary Supplements, U.S. National Library of Medicine, Dec. 2013,

Health Team, eMedicine. �German Chamomile:Uses, Side Effects, Dosage, Interactions & Health Benefits.� EMedicineHealth, EMedicineHealth, 17 Sept. 2019,

Mao, Jun J, et al. �Long-Term Chamomile (Matricaria Chamomilla L.) Treatment for Generalized Anxiety Disorder: A Randomized Clinical Trial.� Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, U.S. National Library of Medicine, 15 Dec. 2016,

Shoara, Ruhollah, et al. �Efficacy and Safety of Topical Matricaria Chamomilla L. (Chamomile) Oil for Knee Osteoarthritis: A Randomized�Controlled Clinical Trial.� Complementary Therapies in Clinical Practice, U.S. National Library of Medicine, Aug. 2015,

Singh, Ompal, et al. �Chamomile (Matricaria Chamomilla L.): An Overview.� Pharmacognosy Reviews, Medknow Publications Pvt Ltd, Jan. 2011,

Srivastava, Janmejai K, et al. �Chamomile: A Herbal Medicine of the Past with Bright Future.� Molecular Medicine Reports, U.S. National Library of Medicine, 1 Nov. 2010,


What Chiropractic Patients Want To Know About Curcumin

What Chiropractic Patients Want To Know About Curcumin

Chronic pain is one of the most prevalent conditions in the United States, affecting an estimated 100 million Americans each year. To put that into perspective, that�s more than the number of people suffering from cancer, heart disease, and diabetes, combined.

Many of these chronic pain sufferers are looking for relief beyond pharmaceuticals which can have unpleasant and even harmful side effects. This has brought them to natural pain management methods like chiropractic care as well as natural substances like curcumin. For many people, these treatment options have brought them relief from the pain and help them return to a more normal lifestyle.

How does it work though? And, more importantly, can it work for you?

What is Curcumin?

curcumin for chronic pain el paso tx.
Natural herbal turmeric capsules with fresh herb leaves and dry curcumin in paper

Curcumin is a spice that is a relative of ginger and is a component of turmeric. Often in the U.S., the terms curcumin and turmeric are used interchangeably. However, curcumin is what gives turmeric its bright yellow color.

While it is often found in curries and other traditional Indian food, it has also long been used to treat a variety of health issues including inflammation that causes pain in the body. These claims have been backed up by several studies that show the tasty spice has tremendous health benefits to offer.

These studies have shown that curcumin has strong anti-inflammatory properties although why it works is not yet completely understood. This information has prompted further studies to determine the efficacy of curcumin in treating a wide range of conditions including chronic pain.

One study examined the spice�s effects on people suffering from arthritis or joint pain. The results determined that turmeric extract (curcumin) supplements were just as effective as ibuprofen in relieving the pain in patients with knee osteoarthritis. It helped to reduce the inflammation that was causing the pain, bringing the patients much-needed relief.

Taking Curcumin for Better Health

You can get curcumin or turmeric supplements, but there is no standard dosage information available. Your chiropractor can advise you on how much to take and which supplement brands are the best.

You can also use the spice in the foods you eat and gain a good bit of the health properties that way. However, it may be more efficient and more comfortable to take curcumin or turmeric supplements, especially when you are treating inflammation and pain.

Curcumin is generally safe with very few side effects. As with any medication or supplement, some people are sensitive to the spice and may experience diarrhea and nausea.

However, that usually occurs at higher doses or after the patient has been using it for a long time. High doses could also pose a risk if the person has ulcers. It can also irritate the skin is applied topically.

If you are considering incorporating curcumin into your daily diet as a health supplement, you should first talk to your doctor or chiropractor to make sure it is safe for you. Women who are pregnant or nursing should not take the supplements.

People with conditions like diabetes, gallbladder issues, bleeding disorders, kidney disease, or immunity problems should take special care when using the supplement. Also, it can interact with medications like NSAIDs, aspirin, diabetes drugs, statins, blood thinners, and blood pressure medications so talk to your health professional, such as your chiropractor, before taking. They may adjust your dosage or recommend certain nutritional therapies to better support the supplement.

Your chiropractor can help you live a more natural, pain-free life and supplements like curcumin may be a part of that plan. They can help put you on the path to a life well lived.

Chronic Pain Treatment

What Are The Risks Of Nrf2 Overexpression?

What Are The Risks Of Nrf2 Overexpression?

The nuclear erythroid 2-related factor 2 signaling pathway, best known as Nrf2, is a protective mechanism which functions as a “master regulator” of the human body’s antioxidant response. Nrf2 senses the levels of oxidative stress within the cells and triggers protective antioxidant mechanisms. While Nrf2 activation can have many benefits, Nrf2 “overexpression” can have several risks. It appears that a balanced degree of NRF2 is essential towards preventing the overall development of a variety of diseases in addition to the general improvement of these health issues. However, NRF2 can also cause complications. The main cause behind NRF2 “overexpression” is due to a genetic mutation or a continuing chronic exposure to a chemical or oxidative stress, among others. Below, we will discuss the downsides of Nrf2 overexpression and demonstrate its mechanisms of action within the human body.


Research studies found that mice that don’t express NRF2 are more inclined to develop cancer in response to physical and chemical stimulation. Similar research studies, however, showed that NRF2 over-activation, or even KEAP1 inactivation, can result in the exacerbation of certain cancers, particularly if those pathways have been interrupted. Overactive�NRF2 can occur through smoking, where continuous NRF2 activation is believed to be the cause of lung cancer in smokers. Nrf2 overexpression might cause cancerous cells not to self-destruct, while intermittent NRF2 activation can prevent cancerous cells from triggering toxin induction. Additionally, because NRF2 overexpression increases the human body’s antioxidant ability to function beyond redox homeostasis, this boosts cell division and generates an unnatural pattern of DNA and histone methylation. This can ultimately�make�chemotherapy and radiotherapy less effective against cancer. Therefore, limiting NRF2 activation with substances like DIM, Luteolin, Zi Cao, or salinomycin could be ideal for patients with cancer although Nrf2 overactivation should not be considered to be the only cause for cancer. Nutrient deficiencies can affect genes, including NRF2. This might be one way as to how deficiencies contribute to tumors.


The overactivation of Nrf2, can also affect the function of specific organs in the human body. NRF2 overexpression can ultimately block the production of the insulin-like growth factor 1, or IGF-1, from the liver, which is essential for the regeneration of the liver.


While the acute overexpression of Nrf2 may have its benefits, continuous overexpression of NRF2 may cause long-term harmful effects on the heart, such as cardiomyopathy. NRF2 expression can be increased through high levels of cholesterol, or the activation of HO-1. This is believed to be the reason why chronic elevated levels of cholesterol might cause cardiovascular health issues.


NRF2 overexpression has also been demonstrated to inhibit the capability to repigment in vitiligo as it might obstruct Tyrosinase, or TYR, action which is essential for repigmentation through melaninogenesis. Research studies have demonstrated that this process may be one of the primary reasons as to why people with vitiligo don’t seem to activate Nrf2 as efficiently as people without vitiligo.

Why NRF2 May Not Function Properly


NRF2 has to be hormetically activated in order to be able to take advantage of its benefits. In other words, Nrf2 shouldn’t trigger every minute or every day,�therefore, it’s a great idea to take breaks from it, by way of instance, 5 days on 5 days off or every other day. NRF2 must also accomplish a specific threshold to trigger its hormetic response, where a small stressor may not be enough to trigger it.

DJ-1 Oxidation

Protein deglycase DJ-1, or just DJ-1, also called the Parkinson’s disease protein, or PARK7, is a master regulator and detector of the redox status in the human body. DJ-1 is essential towards regulating how long NRF2 can perform its function and produce an antioxidant response. In the case that DJ-1 becomes overoxidized, the cells will make the DJ-1 protein less accessible. This process induces NRF2 activation to expire too fast since DJ-1 is paramount for maintaining balanced levels of NRF2 and preventing them from being broken down in the cell. In case the DJ-1 protein is non-existent or overoxidized, NRF2 expression will probably be minimal, even using DIM or alternative NRF2 activators. DJ-1 expression is imperative to restore impaired NRF2 action.

Chronic Illness

If you have a chronic illness, including CIRS, chronic infections/dysbiosis/SIBO, or heavy metal build up, such as mercury and/or that from root canals, these can obstruct the systems of NRF2 and phase two detoxification. Rather than oxidative stress turning NRF2 into an antioxidant, NRF2 will not trigger and oxidative stress can remain in the cell and cause damage, meaning, there is no antioxidant response. This is a significant reason why many people with CIRS have several sensitivities and reach to numerous factors. Some people believe they may be�having a herx response, however, this reaction may only be damaging the cells farther. Treating chronic illness, however, will permit the liver to discharge toxins into the bile, gradually developing the hormetic response of NRF2 activation. If the bile remains toxic and it’s not excreted from the human body, it will reactivate NRF2’s oxidative stress and cause you to feel worse once it’s reabsorbed from the gastrointestinal, or GI, tract. For example, ochratoxin A may block NRF2. Aside from treating the problem, histone deacetylase inhibitors can block the oxidative reaction from a number of the factors which trigger NRF2 activation but it might also prevent NRF2 from triggerring�normally, which might ultimately fail to serve its purpose.

Fish Oil Dysregulation

Cholinergics are substances which boost acetylcholine, or ACh, and choline in the brain through the increase of ACh, particularly when inhibiting the breakdown of ACh. Patients with CIRS often have problems with the dysregulation of acetylcholine levels in the human body, especially in the brain. Fish oil triggers NRF2, activating its protective antioxidant mechanism within the cells. People with chronic illnesses might have problems with cognitive stress and acetylcholine excitotoxicity, from organophosphate accumulation, which might cause fish oil to create�inflammation within the human body. Choline deficiency additionally induces NRF2 activation. Including choline into your diet, (polyphenols, eggs, etc.) can help enhance the effects of cholinergic dysregulation.

What Decreases NRF2?

Decreasing NRF2 overexpression is best for people that have cancer, although it may be beneficial for a variety of other health issues.

Diet, Supplements, and Common Medicines:

  • Apigenin (higher doses)
  • Brucea javanica
  • Chestnuts
  • EGCG (high doses increase NRF2)
  • Fenugreek (Trigonelline)
  • Hiba (Hinokitiol / ?-thujaplicin)
  • High Salt Diet
  • Luteolin (Celery, green pepper, parsley, perilla leaf, and chamomile tea – higher doses may increase NRF2 – 40 mg/kg luteolin three times per week )
  • Metformin (chronic intake)
  • N-Acetyl-L-Cysteine (NAC, by blocking the oxidative response, esp at high doses)
  • Orange Peel (have polymethoxylated flavonoids)
  • Quercetin (higher doses may increase NRF2 – 50 mg/kg/d quercetin)
  • Salinomycin (drug)
  • Retinol (all-trans retinoic acid)
  • Vitamin C when combined with Quercetin
  • Zi Cao (Purple Gromwel has Shikonin/Alkannin)

Pathways and Other:

  • Bach1
  • BET
  • Biofilms
  • Brusatol
  • Camptothecin
  • DNMT
  • DPP-23
  • EZH2
  • Glucocorticoid Receptor signaling (Dexamethasone and Betamethasone as well)
  • GSK-3? (regulatory feedback)
  • HDAC activation?
  • Halofuginone
  • Homocysteine (ALCAR can reverse this homocysteine induce low levels of NRF2)
  • IL-24
  • Keap1
  • MDA-7
  • NF?B
  • Ochratoxin A(aspergillus and pencicllium species)
  • Promyelocytic leukemia protein
  • p38
  • p53
  • p97
  • Retinoic acid receptor alpha
  • Selenite
  • SYVN1 (Hrd1)
  • STAT3 inhibition (such as Cryptotanshinone)
  • Testosterone (and Testosterone propionate, although TP intranasally may increase NRF2)
  • Trecator (Ethionamide)
  • Trx1 (via reduction of Cys151 in Keap1 or of Cys506 in the NLS region of Nrf2)
  • Trolox
  • Vorinostat
  • Zinc Deficiency (makes it worse in the brain)

Nrf2 Mechanism Of Action

Oxidative stress triggers through CUL3 where NRF2 from KEAP1, a negative inhibitor, subsequently enters the nucleus of these cells, stimulating the transcription of the AREs, turning sulfides into disulfides, and turning them into more antioxidant genes, leading to the upregulation of antioxidants, such as GSH, GPX, GST, SOD, etc.. The rest of these can be seen in the list below:
  • Increases AKR
  • Increases ARE
  • Increases ATF4
  • Increases Bcl-xL
  • Increases Bcl-2
  • Increases BDNF
  • Increases BRCA1
  • Increases c-Jun
  • Increases CAT
  • Increases cGMP
  • Increases CKIP-1
  • Increases CYP450
  • Increases Cul3
  • Increases GCL
  • Increases GCLC
  • Increases GCLM
  • Increases GCS
  • Increases GPx
  • Increases GR
  • Increases GSH
  • Increases GST
  • Increases HIF1
  • Increases HO-1
  • Increases HQO1
  • Increases HSP70
  • Increases IL-4
  • Increases IL-5
  • Increases IL-10
  • Increases IL-13
  • Increases K6
  • Increases K16
  • Increases K17
  • Increases mEH
  • Increases Mrp2-5
  • Increases NADPH
  • Increases Notch 1
  • Increases NQO1
  • Increases PPAR-alpha
  • Increases Prx
  • Increases p62
  • Increases Sesn2
  • Increases Slco1b2
  • Increases sMafs
  • Increases SOD
  • Increases Trx
  • Increases Txn(d)
  • Increases UGT1(A1/6)
  • Increases VEGF
  • Reduces ADAMTS(4/5)
  • Reduces alpha-SMA
  • Reduces ALT
  • Reduces AP1
  • Reduces AST
  • Reduces Bach1
  • Reduces COX-2
  • Reduces DNMT
  • Reduces FASN
  • Reduces FGF
  • Reduces HDAC
  • Reduces IFN-?
  • Reduces IgE
  • Reduces IGF-1
  • Reduces IL-1b
  • Reduces IL-2
  • Reduces IL-6
  • Reduces IL-8
  • Reduces IL-25
  • Reduces IL-33
  • Reduces iNOS
  • Reduces LT
  • Reduces Keap1
  • Reduces MCP-1
  • Reduces MIP-2
  • Reduces MMP-1
  • Reduces MMP-2
  • Reduces MMP-3
  • Reduces MMP-9
  • Reduces MMP-13
  • Reduces NfkB
  • Reduces NO
  • Reduces SIRT1
  • Reduces TGF-b1
  • Reduces TNF-alpha
  • Reduces Tyr
  • Reduces VCAM-1
  • Encoded from the NFE2L2 gene, NRF2, or nuclear erythroid 2-related factor 2, is a transcription factor in the basic leucine zipper, or bZIP, superfamily which utilizes a Cap’n’Collar, or CNC structure.
  • It promotes nitric enzymes, biotransformation enzymes, and xenobiotic efflux transporters.
  • It is an essential regulator at the induction of the phase II antioxidant and detoxification enzyme genes, which protect cells from damage caused by oxidative�stress and electrophilic attacks.
  • During homeostatic conditions, Nrf2 is sequestered in the cytosol through bodily attachment of the N-terminal domain of Nrf2, or the Kelch-like ECH-associated protein or Keap1, also referred to as INrf2 or Inhibitor of Nrf2, inhibiting Nrf2 activation.
  • It may also be controlled by mammalian selenoprotein thioredoxin reductase 1, or TrxR1, which functions as a negative regulator.
  • Upon vulnerability to electrophilic stressors, Nrf2 dissociates from Keap1, translocating into the nucleus, where it then heterodimerizes with a range of transcriptional regulatory protein.
  • Frequent interactions comprise with those of transcription authorities Jun and Fos, which can be members of the activator protein family of transcription factors.
  • After dimerization, these complexes then bind to antioxidant/electrophile responsive components ARE/EpRE and activate transcription, as is true with the Jun-Nrf2 complex, or suppress transcription, much like the Fos-Nrf2 complex.
  • The positioning of the ARE, which is triggered or inhibited, will determine which genes are transcriptionally controlled by these variables.
  • When ARE is triggered:
  1. Activation of the�synthesis of antioxidants is capable of detoxifying ROS like catalase, superoxide-dismutase, or SOD, GSH-peroxidases, GSH-reductase, GSH-transferase, NADPH-quinone oxidoreductase, or NQO1, Cytochrome P450 monooxygenase system, thioredoxin, thioredoxin reductase, and HSP70.
  2. Activation of this GSH synthase permits a noticeable growth of the�GSH intracellular degree, which is quite protective.
  3. The augmentation of this synthesis and degrees of phase II enzymes like UDP-glucuronosyltransferase, N-acetyltransferases, and sulfotransferases.
  4. The upregulation of HO-1, which is a really protective receptor with a potential growth of CO that in conjunction with NO allows vasodilation of ischemic cells.
  5. Reduction of iron overload through elevated ferritin and bilirubin as a lipophilic antioxidant. Both the phase II proteins along with the antioxidants are able to fix the chronic oxidative stress and also to revive a normal redox system.
  • GSK3? under the management of AKT and PI3K, phosphorylates Fyn resulting in Fyn nuclear localization, which Fyn phosphorylates Nrf2Y568 leading to nuclear export and degradation of Nrf2.
  • NRF2 also dampens the TH1/TH17 response and enriches the TH2 response.
  • HDAC inhibitors triggered the Nrf2 signaling pathway and up-regulated that the Nrf2 downstream targets HO-1, NQO1, and glutamate-cysteine ligase catalytic subunit, or GCLC, by curbing Keap1 and encouraging dissociation of Keap1 from Nrf2, Nrf2 nuclear translocation, and Nrf2-ARE binding.
  • Nrf2 includes a half-life of about 20 minutes under basal conditions.
  • Diminishing the IKK? pool through Keap1 binding reduces I?B? degradation and might be the elusive mechanism by which Nrf2 activation is proven to inhibit NF?B activation.
  • Keap1 does not always have to be downregulated to get NRF2 to operate, such as chlorophyllin, blueberry, ellagic acid, astaxanthin, and tea polyphenols may boost NRF2 and KEAP1 at 400 percent.
  • Nrf2 regulates negatively through the term of stearoyl CoA desaturase, or SCD, and citrate lyase, or CL.




  • C allele – showed a significant risk for and a protective effect against drug resistant epilepsy (DRE)

rs11085735 (I’m AC)

  • associated with rate of decline of lung function in the LHS



  • T allele – protective allele for Parkinsonian disorders – had stronger NRF2/sMAF binding and was associated with the higher MAPT mRNA levels in 3 different regions in brain, including cerebellar cortex (CRBL), temporal cortex (TCTX), intralobular white matter (WHMT)


rs10183914 (I’m CT)

  • T allele – increased levels of Nrf2 protein and delayed age of onset of Parkinson’s by four years

rs16865105 (I’m AC)

  • C allele – had higher risk of Parkinson’s Disease

rs1806649 (I’m CT)

  • C allele – has been identified and may be relevant for breast cancer etiology.
  • associated with increased risk of hospital admissions during periods of high PM10 levels

rs1962142 (I’m GG)

  • T allele – was associated with a low level of cytoplasmic NRF2 expression (P = 0.036) and negative sulfiredoxin expression (P = 0.042)
  • A allele – protected from forearm blood flow (FEV) decline (forced expiratory volume in one second) in relation to cigarette smoking status (p = 0.004)

rs2001350 (I’m TT)

  • T allele – protected from FEV decline (forced expiratory volume in one second) in relation to cigarette smoking status (p = 0.004)

rs2364722 (I’m AA)

  • A allele – protected from FEV decline (forced expiratory volume in one second) in relation to cigarette smoking status (p = 0.004)


  • C allele – associated with significantly reduced FEV in Japanese smokers with lung cancer


  • G allele – showed a significant risk for and a protective effect against drug resistant epilepsy (DRE)
  • AA alleles – showed significantly reduced KEAP1 expression
  • AA alleles – was associated with an increased risk of breast cancer (P = 0.011)

rs2886161 (I’m TT)

  • T allele – associated with Parkinson’s Disease


  • A allele – was associated with low NRF2 expression (P = 0.011; OR, 1.988; CI, 1.162�3.400) and the AA genotype was associated with a worse survival (P = 0.032; HR, 1.687; CI, 1.047�2.748)

rs35652124 (I’m TT)

  • A allele – associated with higher associated with age at onset for Parkinson’s Disease vs G allele
  • C allele – had increase NRF2 protein
  • T allele – had less NRF2 protein and greater risk of heart disease and blood pressure

rs6706649 (I’m CC)

  • C allele – had lower NRF2 protein and increase risk for Parkinson’s Disease

rs6721961 (I’m GG)

  • T allele – had lower NRF2 protein
  • TT alleles – association between cigarette smoking in heavy smokers and a decrease in semen quality
  • TT allele – was associated with increased risk of breast cancer [P = 0.008; OR, 4.656; confidence interval (CI), 1.350�16.063] and the T allele was associated with a low extent of NRF2 protein expression (P = 0.0003; OR, 2.420; CI, 1.491�3.926) and negative SRXN1 expression (P = 0.047; OR, 1.867; CI = 1.002�3.478)
  • T allele – allele was also nominally associated with ALI-related 28-day mortality following systemic inflammatory response syndrome
  • T allele – protected from FEV decline (forced expiratory volume in one second) in relation to cigarette smoking status (p = 0.004)
  • G allele – associated with increased risk of ALI following major trauma in European and African-Americans (odds ratio, OR 6.44; 95% confidence interval
  • AA alleles – associated with infection-induced asthma
  • AA alleles – exhibited significantly diminished NRF2 gene expression and, consequently, an increased risk of lung cancer, especially those who had ever smoked
  • AA alleles – had a significantly higher risk for developing T2DM (OR 1.77; 95% CI 1.26, 2.49; p = 0.011) relative to those with the CC genotype
  • AA alleles – strong association between wound repair and late toxicities of radiation (associated with a significantly higher risk for developing late effects in African-Americans with a trend in Caucasians)
  • associated with oral estrogen therapy and risk of venous thromboembolism in postmenopausal women

rs6726395 (I’m AG)

  • A allele – protected from FEV1 decline (forced expiratory volume in one second) in relation to cigarette smoking status (p = 0.004)
  • A allele – associated with significantly reduced FEV1 in Japanese smokers with lung cancer
  • GG alleles – had higher NRF2 levels and decreased risk of macular degeneration
  • GG alleles – had higher survival with Cholangiocarcinoma

rs7557529 (I’m CT)

  • C allele – associated with Parkinson’s Disease
Dr Jimenez White Coat
Oxidative stress and other stressors can cause cell damage which may eventually lead to a variety of health issues. Research studies have demonstrated that Nrf2 activation can promote the human body’s protective antioxidant mechanism, however, researchers have discussed that Nrf2 overexpression can have tremendous risks towards overall health and wellness. Various types of cancer can also occur with Nrf2 overactivation. Dr. Alex Jimenez D.C., C.C.S.T. Insight

Sulforaphane and Its Effects on Cancer, Mortality, Aging, Brain and Behavior, Heart Disease & More

Isothiocyanates are some of the most important plant compounds you can get in your diet. In this video I make the most comprehensive case for them that has ever been made. Short attention span? Skip to your favorite topic by clicking one of the time points below. Full timeline below. Key sections:
  • 00:01:14 – Cancer and mortality
  • 00:19:04 – Aging
  • 00:26:30 – Brain and behavior
  • 00:38:06 – Final recap
  • 00:40:27 – Dose
Full timeline:
  • 00:00:34 – Introduction of sulforaphane, a major focus of the video.
  • 00:01:14 – Cruciferous vegetable consumption and reductions in all-cause mortality.
  • 00:02:12 – Prostate cancer risk.
  • 00:02:23 – Bladder cancer risk.
  • 00:02:34 – Lung cancer in smokers risk.
  • 00:02:48 – Breast cancer risk.
  • 00:03:13 – Hypothetical: what if you already have cancer? (interventional)
  • 00:03:35 – Plausible mechanism driving the cancer and mortality associative data.
  • 00:04:38 – Sulforaphane and cancer.
  • 00:05:32 – Animal evidence showing strong effect of broccoli sprout extract on bladder tumor development in rats.
  • 00:06:06 – Effect of direct supplementation of sulforaphane in prostate cancer patients.
  • 00:07:09 – Bioaccumulation of isothiocyanate metabolites in actual breast tissue.
  • 00:08:32 – Inhibition of breast cancer stem cells.
  • 00:08:53 – History lesson: brassicas were established as having health properties even in ancient Rome.
  • 00:09:16 – Sulforaphane’s ability to enhance carcinogen excretion (benzene, acrolein).
  • 00:09:51 – NRF2 as a genetic switch via antioxidant response elements.
  • 00:10:10 – How NRF2 activation enhances carcinogen excretion via glutathione-S-conjugates.
  • 00:10:34 – Brussels sprouts increase glutathione-S-transferase and reduce DNA damage.
  • 00:11:20 – Broccoli sprout drink increases benzene excretion by 61%.
  • 00:13:31 – Broccoli sprout homogenate increases antioxidant enzymes in the upper airway.
  • 00:15:45 – Cruciferous vegetable consumption and heart disease mortality.
  • 00:16:55 – Broccoli sprout powder improves blood lipids and overall heart disease risk in type 2 diabetics.
  • 00:19:04 – Beginning of aging section.
  • 00:19:21 – Sulforaphane-enriched diet enhances lifespan of beetles from 15 to 30% (in certain conditions).
  • 00:20:34 – Importance of low inflammation for longevity.
  • 00:22:05 – Cruciferous vegetables and broccoli sprout powder seem to reduce a wide variety of inflammatory markers in humans.
  • 00:23:40 – Mid-video recap: cancer, aging sections
  • 00:24:14 – Mouse studies suggest sulforaphane might improve adaptive immune function in old age.
  • 00:25:18 – Sulforaphane improved hair growth in a mouse model of balding. Picture at 00:26:10.
  • 00:26:30 – Beginning of brain and behavior section.
  • 00:27:18 – Effect of broccoli sprout extract on autism.
  • 00:27:48 – Effect of glucoraphanin on schizophrenia.
  • 00:28:17 – Start of depression discussion (plausible mechanism and studies).
  • 00:31:21 – Mouse study using 10 different models of stress-induced depression show sulforaphane similarly effective as fluoxetine (prozac).
  • 00:32:00 – Study shows direct ingestion of glucoraphanin in mice is similarly effective at preventing depression from social defeat stress model.
  • 00:33:01 – Beginning of neurodegeneration section.
  • 00:33:30 – Sulforaphane and Alzheimer’s disease.
  • 00:33:44 – Sulforaphane and Parkinson’s disease.
  • 00:33:51 – Sulforaphane and Hungtington’s disease.
  • 00:34:13 – Sulforaphane increases heat shock proteins.
  • 00:34:43 – Beginning of traumatic brain injury section.
  • 00:35:01 – Sulforaphane injected immediately after TBI improves memory (mouse study).
  • 00:35:55 – Sulforaphane and neuronal plasticity.
  • 00:36:32 – Sulforaphane improves learning in model of type II diabetes in mice.
  • 00:37:19 – Sulforaphane and duchenne muscular dystrophy.
  • 00:37:44 – Myostatin inhibition in muscle satellite cells (in vitro).
  • 00:38:06 – Late-video recap: mortality and cancer, DNA damage, oxidative stress and inflammation, benzene excretion, cardiovascular disease, type II diabetes, effects on the brain (depression, autism, schizophrenia, neurodegeneration), NRF2 pathway.
  • 00:40:27 – Thoughts on figuring out a dose of broccoli sprouts or sulforaphane.
  • 00:41:01 – Anecdotes on sprouting at home.
  • 00:43:14 – On cooking temperatures and sulforaphane activity.
  • 00:43:45 – Gut bacteria conversion of sulforaphane from glucoraphanin.
  • 00:44:24 – Supplements work better when combined with active myrosinase from vegetables.
  • 00:44:56 – Cooking techniques and cruciferous vegetables.
  • 00:46:06 – Isothiocyanates as goitrogens.
According to research studies, Nrf2, is a fundamental transcription factor which activates the cells’ protective antioxidant mechanisms to detoxify the human body. The overexpression of Nrf2, however, can cause health issues. The scope of our information is limited to chiropractic and spinal health issues. To discuss the subject matter, please feel free to ask Dr. Jimenez or contact us at�915-850-0900�. Curated by Dr. Alex Jimenez
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Additional Topic Discussion:�Acute Back Pain

Back pain�is one of the most prevalent causes of disability and missed days at work worldwide. Back pain attributes to the second most common reason for doctor office visits, outnumbered only by upper-respiratory infections. Approximately 80 percent of the population will experience back pain at least once throughout their life. The spine is a complex structure made up of bones, joints, ligaments, and muscles, among other soft tissues. Injuries and/or aggravated conditions, such as�herniated discs, can eventually lead to symptoms of back pain. Sports injuries or automobile accident injuries are often the most frequent cause of back pain, however, sometimes the simplest of movements can have painful results. Fortunately, alternative treatment options, such as chiropractic care, can help ease back pain through the use of spinal adjustments and manual manipulations, ultimately improving pain relief.  
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