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Herbs

Back Clinic Herbs Functional Medicine Team. A medication prepared from plants, including most of the world’s traditional remedies for disease. Most think of herbal remedies as products sold over the counter as “supplements,” such as saw palmetto extract or some ointment. However, many over-the-counter and prescription drugs are based on ingredients derived from plants, including aspirin and digoxin. Lab tests show that some herbal remedies are effective against illness. An Individual should use these drugs as carefully as prescription medicines, using caution to avoid overdose, interactions with other medications, and misuse.

Herbal medicines are one type of dietary supplement. They are sold as tablets, capsules, powders, teas, extracts, and fresh or dried plants. People use herbal medicines to maintain or improve health. Many believe that products labeled “natural” are safe to use. This is not true, as herbal medicines do not have to go through the testing that drugs do. Some herbs, such as comfrey and ephedra, can cause serious harm. In addition, certain herbs interaction with a prescription or over-the-counter medicines can work well with other medicines and be dangerous. Before using herbal medicines, first, get information from reliable sources and tell your health care provider about any herbal medicines you are taking.


Thyme To Heal The Body

Thyme To Heal The Body

Do you feel:

  • Pain, tenderness, soreness on the left side?
  • Stomach pains, burning, or aching, 1-4 hours after eating?
  • Digestive problems subside with rest and relaxation?
  • Unpredictable abdominal swelling?
  • An overall sense of bloating?

If you are experiencing any of these situations, then something might be wrong in your body, especially in the gut. Why not try to add some thyme into your food.

Thyme

In the culinary world, thyme is usually associated with savory dishes that compliment the flavors. This leafy herb can be combined with chicken and can give food dishes like stuffing, sauces, stews and soups a boost in the flavor department. Even though thyme is a culinary herb, surprisingly, there is some history with this leafy herb that not everyone knows about yet. History shows that thyme was used as an embalmment by Ancient Egyptians, while Ancient Greece was using thyme as incense for their temples. History even showed that thyme has a �purifying� aroma that helped people ward off nightmares in the Middle Ages. In today’s world, thyme is well-known for its ability to enhance the flavors in the cooking world. However, it is even better known for its medicinal purifying properties for functional medicine.

Studies have found out that about approximately 1/3 of all deaths in the world are due to infectious diseases. In contrast, an alarming number of microorganisms have now become resistant to antibiotic therapy. Surprisingly though, scientists are trying to find ways to look for alternative antimicrobial therapies with thyme. Since plants have a natural defense mechanism that is built into them since they can protect themselves from harsh environmental factors. So, with thyme being a Mediterranean herb, its health properties are beneficial for the body and can dampen the effect of harmful bacterial pathogens.

Beneficial Properties Thyme Possess

Thymol

Some of the beneficial properties that thyme has to offer are amazing since it has been used for medicinal usages. Thyme has a naturally occurring class of compounds known as biocides. Studies show that these compounds are known to destroy any harmful organisms like infectious bacteria, while also having powerful antimicrobial properties. In a 2010 research study, it suggested that thyme can reduce bacterial resistance to some of the common drugs, including penicillin. Some other beneficial properties that thyme presents include:

Blood Pressure

Thyme has been found to help reduce high blood pressure in individuals. Researchers in Serbia have found that wild thyme can reduce the individual�s blood pressure through animal studies. It even showed how rodents are similar to people when they are dealing with hypertension in the body. While another study found out that thyme extract can reduce a raised heart rate while also lowering the bad cholesterol. The study even showed that thyme had been used for treating a variety of various diseases that can harm the body in traditional medicine. It is even possible for thyme to be used as a substitute for salt for food.

Prevent Intestinal Infections

Studies have found out thyme can neutralize certain enteric bacteria that have been associated with some intestinal diseases. In a 2017 research study, scientists have discovered that when subjects have been in contact with the Clostridium perfringens, a harmful bacterium that can harm the intestines, can be treated with thyme. The result shows that the subjects had fewer bacterial infections in their intestines while also having fewer lesions and fewer C. perfringens related deaths.

Boost the Immune System

Even though everyone can try to live a healthy lifestyle, sometimes it is hard to get all the vitamins that the body needs to maintain itself both inside and out. Research has shown that thyme can provide the body a healthy dosage of vitamins C and A. Whenever it is the cold or flu season, thyme can be beneficial to anyone who wants to prevent the cold or flu from happening or at least dampen the symptoms. One of the beneficial properties that thyme can also do for the immune system is that it can be a good source of minerals like copper, fiber, iron, and manganese that the body does need in order to function properly.

Antimicrobial and Antifungal Properties

Thyme has antimicrobial and antifungal properties that are beneficial to the body. A Portugal study had found that thyme can provide anti-cancer activity properties to people who have colon cancer. The study even showed that thyme�s chemical constituents could identify the colon cancer cytotoxicity activities and shortening its process to become worst. Another study found in Turkey showed that wild thyme could have a positive effect on breast cancer activity. The study found that wild thyme extract can be used in novel therapeutic drugs for breast cancer treatment.

For antifungal properties, studies have found that thyme can be beneficial to combatting fungal bacteria in the body like yeast infections. Researchers in Italy have found the fungus Candida albicans is common to cause yeast infections in the mouth and vaginal area. Another study found that thyme essential oil can significantly enhance the destruction of C. Albicans in the body and preventing the fungus from spreading. The results showed that the fungal strands had a biofilm production, and only thyme oil was the only one to be the most inhibitory oil to affect biofilm production of the fungal strands.

Conclusion

There are many beneficial properties that thyme can posses to help not only the body but also the immune system and the gut system as well. It is truly amazing that this herb can have purifying effects on the body and even enhance the flavors of food dishes.�Since more people are using thyme in their culinary dishes, it is no wonder that thyme is a truly, magical herb that can help the body achieve an overall sense of health and wellness. Some products that can be beneficial to the body, including the immune system, by providing support to the intestines for greater stability, bioavailability, and digestive comfort.

The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.


References:

Laboratories, Medical Oncology Research. �Effects of Thymus Serpyllum Extract on Cell Proliferation, Apoptosis and Epigenetic Events in Human Breast Cancer Cells.� Taylor & Francis, 19 Nov. 2012, www.tandfonline.com/doi/full/10.1080/01635581.2012.719658#.Ul_MYWTk-z5.

Team, Biotics Education. �Thyme for Gut Health.� Biotics Research Blog, 2017, blog.bioticsresearch.com/thyme-for-gut-health.

Alamgeer, et al. �Pharmacological Evaluation of Antihypertensive Effect of Aerial Parts of Thymus Linearis Benth.� Acta Poloniae Pharmaceutica, U.S. National Library of Medicine, 2014, www.ncbi.nlm.nih.gov/pubmed/25272894.

Fanous, Summer. �9 Health Benefits of Thyme.� Healthline, 5 May, 2016, www.healthline.com/health/health-benefits-of-thyme.

Felman, Adam. �What Are the Benefits of Thyme?� MedicalNewsToday, 23 Aug. 2018, www.medicalnewstoday.com/articles/266016.

Gordo, Joana, et al. �Thymus Mastichina: Chemical Constituents and Their Anti-Cancer Activity.� Natural Product Communications, U.S. National Library of Medicine, Nov. 2012, www.ncbi.nlm.nih.gov/pubmed/23285814.

Khan, Mohd S A, et al. �Sub-MICs of Carum Copticum and Thymus Vulgaris Influence Virulence Factors and Biofilm Formation in Candida Spp.� BMC Complementary and Alternative Medicine, BioMed Central, 15 Sept. 2014, www.ncbi.nlm.nih.gov/pubmed/25220750.

Kim, Gil-Hah, et al. �Chemical Composition, Larvicidal Action, and Adult Repellency of Thymus Magnus Against Aedes Albopictus.� Journal of the American Mosquito Control Association, The American Mosquito Control Association, 1 Sept. 2012, www.bioone.org/doi/abs/10.2987/12-6250R.1.

Palaniappan, Kavitha, and Richard A. Holley. �Use of Natural Antimicrobials to Increase Antibiotic Susceptibility of Drug Resistant Bacteria.� International Journal of Food Microbiology, Elsevier, 13 Apr. 2010, www.sciencedirect.com/science/article/pii/S0168160510001868.

Team, WHO. �The Top 10 Causes of Death.� World Health Organization, World Health Organization, 24 May 2018, www.who.int/mediacentre/factsheets/fs310/en/.

Wong, Cathy. �The Use of Thyme in Alternative Medicine.� Verywell Health, Verywell Health, 28 Apr. 2020, www.verywellhealth.com/the-benefits-of-thymus-vulgaris-88803.

Yin, D., Du, E., Yuan, J.�et al.�Supplemental thymol and carvacrol increases ileum�Lactobacillus�population and reduces effect of necrotic enteritis caused by�Clostridium perfringes�in chickens.�Sci Rep7,�7334 (2017). https://doi.org/10.1038/s41598-017-07420-4


Modern Integrative Wellness- Esse Quam Videri

The University offers a wide variety of medical professions for functional and integrative medicine. Their goal is to inform individuals who want to make a difference in the functional medical fields with knowledgeable information that they can provide.

Astragalus and The Immune System

Astragalus and The Immune System

Do you feel:

  • Dizziness when standing up quickly?
  • A slow start in the morning?
  • Edema and swelling in ankles and wrist?
  • Muscle cramping?
  • Tired or sluggish?

If you are experiencing any of these situations, then there might be some dysfunction in your body�s system, including the immune system. Why not try the Chinese herb, astragalus to help alleviate the symptoms.

Astragalus

In traditional Chinese medicine, the herb astragalus has been used for thousands of years and has been known to strengthen chi or qi life force in the body. This herb has been known to be typically employed in conditions that are related to general weakness in the body like fatigue, anemia, a poor appetite, cardiovascular diseases, and other conditions that can weaken the body. Surprisingly though, astragalus can be used to optimize kidney health and, with the combination of ginseng and echinacea, can boost up the body’s immune system. There is a variety of astragalus that are native to Northeast Asia, and its roots need to be dried and powdered to be transformed to be consumed as a capsule or as a tea.

Astragalus Beneficial Properties

Studies have found that astragalus�s beneficial pharmacological effects might contain phytochemical components, which include a host of saponins polysaccharides and flavonoids that the body’s immune system needs to function correctly. Another study found that astragalus contains about twenty trace minerals that are highly important for the body. With astragalus extract, it has immune-modulating properties in vivo and in vitro in both animals and humans, and research shows that the herb stimulates and influences on the immune response cytokines while also leaving the inflammatory cytokines unaffected.

Some of the beneficial properties that astragalus can have on the body are still being researched; however, this Chinese herb can help the body to function correctly and are effective.

Improving the Immune System

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Studies have shown that astragalus contains some beneficial plant compounds that may enhance the body’s immune system. Studies show that the primary role for the immune system is that it helps protect the body from foreign pathogens like harmful bacteria and viruses that can cause a person to be ill. Research has found out that there is some evidence that astragalus can increase the body�s production of white blood cells, which will help prevent illnesses from entering the body. In other research studies, it has been found that astragalus root has been known to help the body kill bacteria and viruses caused by infections. Even though the research may be limited, there are still studies that show that astragalus can fight off viral infections like the common cold and liver infections in the human body.

Improving the Heart Function

Research shows that astragalus may be able to improve heart function by widening the blood vessels and increasing the amount of blood that is being pumped from the heart. In a clinical research study, it showed that patients were given at least 2.25 grams of astragalus for two weeks and have experienced a more significant improvement in their heart function. In another study, it shows that astragalus may help reduce the symptoms of myocarditis, which is an inflammatory condition in the heart.

Improving Kidney Function

Astragalus can help support kidney health in the body by improving the blood flow to the kidneys and measuring the protein in the urine. A study has shown that proteinuria is a condition where there is an abnormal amount of protein that is found in urine, and it can be a sign that the kidneys are not functioning normally or may be damaged. Surprisingly, there was another study that showed that astragalus could improve proteinuria symptoms in individuals that have kidney disease. Studies have even found that astragalus may also help prevent infections for anyone who has a reduce kidney function and reducing the risk of a kidney disorder known as nephrotic syndrome.

Conclusion

Astragalus is a unique herb that can help the body’s immune system to function correctly. Even though there is a limited amount of research on this herb, but the beneficial properties it provides in the body are truly amazing. Astragalus can be consumed by capsules or even be brewed as a tea, so that way, people can enjoy the beneficial properties and that their body is performing excellently in health and wellness. Some products offer support to the body’s immune system and help target the amino acids that are intended to support the intestines while offering more support to the metabolic system.

The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.


References:

Block, Keith I, and Mark N Mead. �Immune System Effects of Echinacea, Ginseng, and Astragalus: a Review.� Integrative Cancer Therapies, U.S. National Library of Medicine, Sept. 2003, www.ncbi.nlm.nih.gov/pubmed/15035888.

Fu, Juan, et al. �Review of the Botanical Characteristics, Phytochemistry, and Pharmacology of Astragalus Membranaceus (Huangqi).� Phytotherapy Research: PTR, U.S. National Library of Medicine, Sept. 2014, www.ncbi.nlm.nih.gov/pubmed/25087616.

Gao, Xing-hua, et al. �Saponin Fraction from Astragalus Membranaceus Roots Protects Mice against Polymicrobial Sepsis Induced by Cecal Ligation and Puncture by Inhibiting Inflammation and Upregulating Protein C Pathway.� Journal of Natural Medicines, U.S. National Library of Medicine, Oct. 2009, www.ncbi.nlm.nih.gov/pubmed/19548065.

Meixner, Makayla. �Astragalus: An Ancient Root With Health Benefits.� Healthline, 31 Oct. 2018, www.healthline.com/nutrition/astragalus.

Nalbantsoy, Ay?e, et al. �Evaluation of the Immunomodulatory Properties in Mice and in Vitro Anti-Inflammatory Activity of Cycloartane Type Saponins from Astragalus Species.� Journal of Ethnopharmacology, U.S. National Library of Medicine, 31 Jan. 2012, www.ncbi.nlm.nih.gov/pubmed/22155389.

Peng, T Q, et al. �Effect and Mechanism of Astragalus Membranaceus on Coxsackie B3 Virus RNA in Mice.� Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine, U.S. National Library of Medicine, Nov. 1994, www.ncbi.nlm.nih.gov/pubmed/7703635.

Piao, Yuan-lin, and Xiao-chun Liang. �Astragalus Membranaceus Injection Combined with Conventional Treatment for Viral Myocarditis: a Systematic Review of Randomized Controlled Trials.� Chinese Journal of Integrative Medicine, U.S. National Library of Medicine, Oct. 2014, www.ncbi.nlm.nih.gov/pubmed/25098261.

Team, DFH. �Astragalus: Funny Name Serious Results.� Designs for Health, 9 Oct. 2018, blog.designsforhealth.com/astragalus-funny-name-serious-results.

Team, NCBI. �Astragalus Membranaceus. Monograph.� Alternative Medicine Review: a Journal of Clinical Therapeutic, U.S. National Library of Medicine, Feb. 2003, www.ncbi.nlm.nih.gov/pubmed/12611564.

Wang, Deqing, et al. �Study of the Effects of Total Flavonoids of Astragalus on Atherosclerosis Formation and Potential Mechanisms.� Oxidative Medicine and Cellular Longevity, Hindawi Publishing Corporation, 2012, www.ncbi.nlm.nih.gov/pmc/articles/PMC3306992/.

Wu, Hong Mei, et al. �Interventions for Preventing Infection in Nephrotic Syndrome.� The Cochrane Database of Systematic Reviews, John Wiley & Sons, Ltd, 18 Apr. 2012, www.ncbi.nlm.nih.gov/pubmed/22513919.

Yang, Qing-you, et al. �Effects of Astragalus on Cardiac Function and Serum Tumor Necrosis Factor-Alpha Level in Patients with Chronic Heart Failure.� Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine, U.S. National Library of Medicine, July 2010, www.ncbi.nlm.nih.gov/pubmed/20929124.

Zhang, Hong Wei, et al. �Astragalus (a Traditional Chinese Medicine) for Treating Chronic Kidney Disease.� The Cochrane Database of Systematic Reviews, U.S. National Library of Medicine, 22 Oct. 2014, www.ncbi.nlm.nih.gov/pubmed/25335553.


Modern Integrative Wellness- Esse Quam Videri

The University offers a wide variety of medical professions for functional and integrative medicine. Their goal is to inform individuals who want to make a difference in the functional medical fields with knowledgeable information that they can provide.

The Wonderful Benefits of Sage

The Wonderful Benefits of Sage

Do you feel:

  • Inflammation in the joint and the mouth?
  • Your glucose levels rising a little bit?
  • Unpredictable abdominal swelling?
  • Hormone imbalances?
  • Weight gain?

If you are experiencing any of these situations, then why not try adding some sage into your dishes.

Sage

Throughout the world in the culinary arts and the health world, traditional foods and tasty recipes always required certain spices and herbs that will boost the flavors of the dishes that a person is creating to be consumed. Like for example, sweet potatoes pairing with cinnamon, it is like tasting heaven. Any meat products or vegetables thrive when a person is seasoning these products with many herbs and spices. The herb salvia officinalis or sage fills the air with its aroma and enhances the flavor of many foods.

SAGE_HEADER

Like any other herbs, sage is a powerhouse in the nutritional food world. Studies show how a large quantity of sage can have a significant amount of micronutrients when it is seasoning poultry and different kinds of animal meat products. What is a surprise of this herb is that it is not just to make poultry mouthwatering, but sage can be used as an essential oil as well. Research shows that sage essential oil can exhibit antimicrobial effects against any harmful bacteria that enter the body. It even has antioxidant properties to protect the body against lipid peroxidation.

Sage Benefits

There are many benefits that sage can provide the body and can protect the body�s cells from free radicals that can damage the body and impaired not only the immunity but can also develop chronic diseases. Some of the beneficial properties that sage can provide are:

Treating Alzheimer�s

Sage can have a positive impact on a person�s cognitive skills and can protect the brain from neurological disorders, like Alzheimer�s disease. In a recent study, it showed how sage is a cognitive- enhancing agent to increase the brain’s function. Since sage has been used in traditional remedies to treat a wide range of problems in the digestive tract and body circulation. It can enhance the head and brain function by improving a person’s memory, quicken their senses, and delay any age-associated cognitive diseases.

Lowers Glucose and Cholesterol

Sage can help lower the body�s glucose and cholesterol levels. One study showed how 40 participants with diabetes and high cholesterol took sage leaf extract for at least three months, and the results were astounding. The results showed that the participants had low levels of glucose and low levels of cholesterol.

Another study found that people who have type 2 diabetes use sage to lower their blood sugar levels to prevent DKA (diabetic ketoacidosis). The study concluded that sage could be beneficial for anyone that has diabetes to reduce glucose levels. By consuming sage into a person�s diet is marvelous because of the properties that it provides for anyone who may have a higher glucose level or even a high level of cholesterol.

Reduces Inflammation

There is more evidence that sage has certain compounds that has anti-inflammatory actions. Studies show that sage has beneficial anti-inflammatory effects for inflammation in the connective tissues of the gums in the mouth. Sage’s anti-inflammatory properties have been used in a dentist’s office since it is used as an oral antiseptic to dull the pain of gingival fibroblasts.

Ease Menopause Symptoms

When the body experiences a natural decline of hormones, both males and females can experience menopause, and this can cause a wide range of unpleasant symptoms for anybody. From hot flashes, excessive sweating, low levels of testosterone and estrogen, to mood swings, and even being irritable. Studies have shown that common sage has been used as a traditional medicine to reduce menopause symptoms from the body. There are even more studies showing that the sage has estrogen-like properties that will allow the compounds to bind to neurological receptors in the brain to improve the body�s cognitive memory and function.

Conclusion

There are many usages for sage as this herb is a powerhouse when it comes to everyday products. Sage can even be used to purify the toxins that are in the air and seasoned poultry and different kinds of meats. With its anti-inflammatory properties, it can dampen inflammation and prevent it from turning into chronic inflammation in the body. So by adding sage into dishes can not only boost the dishes that need sage in the recipes but can also provide beneficial properties to the body. Some products can help support the immune system and are designed for more excellent stability, bioavailability, and digestive comfort.

The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.


References:

Bozin, Biljana, et al. �Antimicrobial and Antioxidant Properties of Rosemary and Sage (Rosmarinus Officinalis L. and Salvia Officinalis L., Lamiaceae) Essential Oils.� Journal of Agricultural and Food Chemistry, U.S. National Library of Medicine, 19 Sept. 2007, www.ncbi.nlm.nih.gov/pubmed/17708648.

Fawzi, Muntaha, et al. �Anti-Inflammatory Effect of Sage (Salvia Officinalis) Extracts ABSTRACT on Oral Health.� Iraqi Dental Journal, 2017, iraqidentaljournal.com/index.php/idj/article/view/111/69.

Kargozar, Rahele, et al. �A Review of Effective Herbal Medicines in Controlling Menopausal Symptoms.� Electronic Physician, Electronic Physician, 25 Nov. 2017, www.ncbi.nlm.nih.gov/pubmed/29403626.

Lopresti, Adrian L. �Salvia (Sage): A Review of Its Potential Cognitive-Enhancing and Protective Effects.� Drugs in R&D, Springer International Publishing, Mar. 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5318325/.

Rahte, Sinikka, et al. �Salvia Officinalis for Hot Flushes: towards Determination of Mechanism of Activity and Active Principles.� Planta Medica, U.S. National Library of Medicine, June 2013, www.ncbi.nlm.nih.gov/pubmed/23670626.

Team, DFH. �Sage Is All the Rage (or at Least It Should Be!).� Designs for Health, 23 Dec. 2019, blog.designsforhealth.com/node/727.

Ware, Megan. �Sage: Health Benefits, Facts, and Research.� Medical News Today, MediLexicon International, 10 Jan. 2018, www.medicalnewstoday.com/articles/266480.php.


Modern Integrative and Functional Wellness- Esse Quam Videri

By informing individuals about how the National University of Health Sciences provides knowledge for future generations who want to make a difference in the world. The University offers a wide variety of medical professions for functional and integrative medicine.

 

 

Tis The Season For These Botanical Herbs

Tis The Season For These Botanical Herbs

Do you feel:

  • Unpredictable abdominal swelling?
  • Hormone imbalance?
  • Occasional stress?
  • Inflammation in the gut?
  • Weight gain?

If you are experiencing any of these situations, then why not try these botanical herbs in your food dish.

The holiday season brings out the joy out of people with holiday traditions and its unique, universal foods, drinks, seasonal herbs, and spices to the table. The colder seasons are where everyone in the U.S. indulges in hearty soups, pumpkin spice products, root vegetables, and turkey leftovers. Many holiday menu items will incorporate sweet and savory herbs and spices in their food dishes. What people do not realize is that even though these herbs and spices enhance the flavors of the food, they also provide a plethora of health benefits for the body. So using these herbs and spices in the kitchen can help increase the person’s chances to receive their beneficial properties, hence “the more, the merrier.”

Lavender-Herb-Wreath-2-lg_large

Throughout the centuries, medicinal plants have been traditionally used by a variety of cultures. Some of nature’s most potent herbs are most used in culinary dishes, while also providing the beneficial properties to the human body; they are rosemary, sage, and clove.

Rosemary

Being commonly used as a condiment and a food preservative, rosemary is a native herb in the Mediterranean region. A review did an animal study of in vivo and in vitro that showed that rosemary had demonstrated similar beneficial effects to any medications that are for a variety of physiological disorders. Some of the physiological disorders include:

  • Lead hepato-nephrotoxicity
  • Stress
  • Anxiety
  • Bodyweight and dyslipidemia
  • Pain
  • Cerebral ischemia

Another review was looking at how rosemary has antimicrobial and antioxidant properties and that its abundance in isoprenoid quinones. The review stated that rosemary could �act as chain terminators for free radicals and as chelators for ROS (reactive oxygen species.)” The antioxidative properties in rosemary have about the majority of phenolic diterpenes; like carnosic acid and carnosol, that are responsible for about 90% of this herb. Since it inhibits lipid peroxidation, scavenge radicals, and helps reduce cytochrome c by activating the redox-dependent signaling pathways in the body.

With carnosic acid, it has been shown to provide superior antimicrobial actions to other significant constituents that are found in rosemary. Furthermore, there have been studies shown that rosemary has antibacterial effectiveness against resistant bacteria in the body.

Sage

Sage is another herb that is native to the Mediterranean and Middle East regions and has been used in traditional folk medicine to treat a variety of disorders in the body. There is recent research that has suggested that sage can possess a wide range of beneficial properties for the body due to the presence of carnosic acid and carnosol in this herb. Another study showed that sage contains high contents of glycosidic flavones that provide functional inhibitory capacity against xanthine oxidase activity in the body. Some of the beneficial properties include:

  • Anti-inflammatory
  • Antinociceptive
  • Antibacterial
  • Hypoglycemic
  • Antioxidative

There is further research that demonstrates how sage has powerful cognitive enhancing and neuroprotective properties. Studies show that patients with Alzheimer�s disease took a 4-month supplementation of sage, and the results are remarkable. Alzheimer patients experienced significant improvements in their cognitive function and mood enhancements. In another study, sage extract can help reduce the severity of physical and psychological systems that are experienced in premenstrual syndrome in the body. A recent article showed how freshly harvested sage leaves can become a potent modulator for neuroreceptor pathways that involves serotonin transporters that may help normalize thermoregulation and mental impairment for menopausal women.

Surprisingly though, both rosemary and sage have been proven and shown that they can help improve gabaergic pathways in the brain and can help decrease the neuronal activities that are associated with anxiety disorders. Studies show that rosemary and sage extracts have hepatoprotective and antioxidative roles that can increase catalase and glutathione levels and decrease lipid peroxidation in the body.

Cloves

Clove buds were initially found in east Indonesia, and it plays a role as the herb has a potent antimicrobial and antioxidative botanical. Research shows that clove oil possesses a bactericidal effect against pathogenic species that can harm the body. Earlier this year, a research study found out that clove oil extract can enhance anti-inflammatory activity by reducing myeloperoxidase activity in human neutrophils significantly. This herb can help reduce ROS and a variety of other inflammatory mediators that can promote significant damage to the body at the site of inflammation.

Conclusion

So for the holidays, adding these three powerful herbs to the next holiday feast are not just there to help enhance the flavors of the dishes, but they are beneficial to the body. Since they provide anti-inflammatory properties to the body by decreasing the inflammatory responses. So for the colder seasons, add that extra dash of herbs into the dish recipe will make anyone’s day merry. Some products are specialized in countering the metabolic effects of temporary stress and can support the body.

The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.


References:

Chniguir, Amina, et al. �Syzygium Aromaticum Aqueous Extract Inhibits Human Neutrophils Myeloperoxidase and Protects Mice from LPS-Induced Lung Inflammation.� Pharmaceutical Biology, Taylor & Francis, Dec. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6366422/#!po=2.63158.

Choukairi, Zineb, et al. �Effect of Salvia Officinalis L. and Rosmarinus Officinalis L. Leaves Extracts on Anxiety and Neural Activity.� Bioinformation, Biomedical Informatics, 15 Mar. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6637401/.

de Oliveira, Jonatas Rafael, et al. �Rosmarinus Officinalis L. (Rosemary) as Therapeutic and Prophylactic Agent.� Journal of Biomedical Science, BioMed Central, 9 Jan. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6325740/.

Lopresti, Adrian L. �Salvia (Sage): A Review of Its Potential Cognitive-Enhancing and Protective Effects.� Drugs in R&D, Springer International Publishing, Mar. 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5318325/.

Nieto, Gema, et al. �Antioxidant and Antimicrobial Properties of Rosemary (Rosmarinus Officinalis, L.): A Review.� Medicines (Basel, Switzerland), MDPI, 4 Sept. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6165352/.

Pavi?, Valentina, et al. �Extraction of Carnosic Acid and Carnosol from Sage (Salvia Officinalis L.) Leaves by Supercritical Fluid Extraction and Their Antioxidant and Antibacterial Activity.� Plants (Basel, Switzerland), MDPI, 9 Jan. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6359053/.

Pereira, Ol�via R, et al. �Salvia Elegans, Salvia Greggii and Salvia Officinalis Decoctions: Antioxidant Activities and Inhibition of Carbohydrate and Lipid Metabolic Enzymes.� Molecules (Basel, Switzerland), MDPI, 1 Dec. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6321363/.

Team, DFH. �Spice Up the Holidays with Medicinal Botanicals.� Designs for Health, 25 Nov. 2019, blog.designsforhealth.com/node/1156.

Tober, Carsten, and Roland Schoop. �Modulation of Neurological Pathways by Salvia Officinalis and Its Dependence on Manufacturing Process and Plant Parts Used.� BMC Complementary and Alternative Medicine, BioMed Central, 13 June 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6567565/.

 

 

 

 

 

Chamomile and Inflammation

Chamomile and Inflammation

Do you feel:

  • Anxious or cannot focus on tasks?
  • Do digestive problems subside with rest or relaxation?
  • Stomach pains, burning, or aching 1-4 hours after eating?
  • Redden skin?
  • Nausea or vomiting?

If you are experiencing any of these situations, then you might be experiencing some digestive stress. Try some chamomile to reduce that stress and anxious mind.

Chamomile and its products are well-known for encouraging a healthy state of mind and for enhancing amazing sleep quality for anyone who takes this herb. This white and yellow blossom, however, has several impressive health benefits that are beneficial with anyone that’s feeling anxious in their daily, hectic lives and can provide other benefits for the body that has some ailments.

What is Chamomile?

Chamomile is an ancient medicinal plant by the Asteraceae family and is frequently known as the “earth apple on the ground” due to the apple-like fragrance it produces. Its blossoms have unique properties that could boost a person�s wellbeing and supplying beneficial nutrients that are remarkable for the body to relax and feel calm. This plant has existed for centuries and is native to eastern and southern Europe. Tons of research have shown that chamomile has been used in herbal remedies in ancient times during the Roman era, Greek era and Egypt era. The plant contains a thin spindle-shaped stem that produces tiny flower blossoms that resemble a daisy.

Chamomile Benefits

chamomile-flower-tea-steeped-z_1200x1200.jpg

The chemicals of chamomile can serve as antioxidants in the human body and can prevent flare-ups from occurring. Because of this, when an individual is consuming chamomile goods; the health properties might help prevent the common cold, intestinal disorders from the gut, inflammation and many more body ailments that can affect the human body from functioning properly. There are two varieties of chamomile that have amazing properties that have been used for natural remedies are the German chamomile and the Roman chamomile.

  • German Chamomile: This type of chamomile is popular around the world and native to southern and eastern Europe. Studies have shown that people would take chamomile by the mouth to relieve ailments caused by environmental factors. There are some people that will even apply chamomile on their skin as an ointment. There is some scientific evidence that using German chamomile as an oral rinse could be helpful for cancer patients that have mucositis, which is inflammation and ulceration of the mucosal membrane lining in the digestive tract caused from chemotherapy and radiotherapy.
  • Roman Chamomile: This type of chamomile provides the same benefits as German Chamomile as it relieves the same ailments that environmental factors caused but also provides a bit more help to the body. Roman chamomile has hypnotic properties that help a person relax and falls asleep faster. There have been studies that this herb offered hypnotic effects to animals and when consumed, it decreased the amount of time for them to fall asleep.

The benefits that the chamomile plant provides are that it promotes the body to relax and other benefits that are essential to the body. When it is used as an essential oil for aromatherapy, the patient can feel less anxious when they breathe in the vapors and finally let their anxious mind relax.

Reducing Pain

The anti-inflammatory effect that both the essential oil and the chamomile flower itself can aid the body by reducing the pain that it has encountered. Since the chamomile plant has been used for hundreds, people have been using this plant to help reduce pain from inflammatory-related symptoms in the body they might be experiencing.

Studies have shown that people who consume herbal tea for their joint inflammation have shown an improvement especially in the knees and lower back. The antioxidant and anti-inflammatory properties that this herbal tea produces polyphenols that affect systemic inflammation and joint function in the body. Another study shows that patients with knee osteoarthritis used chamomile oil to decrease the stiffness in their joints and provide some beneficial effects on their physical function.

Heals and Promotes Skin Health

For anyone that has eczema and uses topical creams to reduce the redness, they might want to try using chamomile essential oil. The benefits of using chamomile essential oil are that it can help reduce irritated skin. A person can mix the chamomile essential oil with a carrier oil or lotion and apply it to their skin as the anti-inflammatory and antibacterial properties can calm down the red, dry, irritated skin while also decreasing breakouts from happening.

In some instances, there have been statements that chamomile is more effected than hydrocortisone lotion for skin lesions. Researchers found in a 2010 study, that German chamomile oil has been used to alleviate atopic dermatitis, which is a chronic skin disorder, by containing three major sesquiterpene constituents (azulene, bisabolol, and farnesene) by healing the skin gradually.

Improving Digestion

Another widespread use for chamomile, especially when it is brewed in a tea, is reducing unwanted symptoms that are associated with poor digestion in the digestive system. With chamomile tea, it can soothe an upset stomach, cramping, flatulence, and diarrhea. The therapeutic compounds that are found in chamomile can act as a digestive relaxant.

Improves Sleep and Relaxation

When it is brewed into a tea, chamomile can promote a person�s frame in mind and can enhance their sleep quality to provide them the necessary 8 hours of sleep. Research shows that individuals who drink chamomile tea before going to bed, have a better night’s sleep and relaxing a bit more. Apigenin provides a stimulant effect from chamomile tea and is bind with the benzodiazepine receptors in the brain, providing benefits that can help reduce stress from the body while also promoting a good night�s sleep.

In a 2017 study, the research shows that adults over the age of 60, consumed chamomile tea before they go to bed. The results showed that their sleep quality improved by reducing sleep complications like sleep apnea and the consumption of using sleep medication while improving their moods drastically over time.

Boosting Mental Wellness

Using chamomile products can benefit a person�s wellness. Since chamomile has beneficial properties to make the body relax, it can also help reduce the sensation of depression and anxiety in a person when it is consumed. Studies have stated that long-term chamomile intake is safe and may considerably reduce the effects of moderate to severe GAD symptoms in the body. Even using the oil for aromatherapy can be considered as an alternative for treatments for patients.

Conclusion

Thus chamomile is an effective and secured plant that has been used by individuals who have been experiencing a number of symptoms. Since chamomile is excellent for reducing pain, have better skin, improve mental health and provide many beneficial factors. When it is used in aromatherapy or consumed into the body, chamomile is a natural cure for a nervous mind. Some products combined with chamomile are designed to offer support to the gastrointestinal tract and make sure that sugar metabolism is functioning properly.

The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.


References:

Abdullahzadeh, Mehrdad, et al. �Investigation Effect of Oral Chamomilla on Sleep Quality in Elderly People in Isfahan: A Randomized Control Trial.� Journal of Education and Health Promotion, Medknow Publications & Media Pvt Ltd, 5 June 2017, www.ncbi.nlm.nih.gov/pubmed/28616420.

Charousaei, Firuzeh, et al. �Using Chamomile Solution or a 1% Topical Hydrocortisone Ointment in the Management of Peristomal Skin Lesions in Colostomy Patients: Results of a Controlled Clinical Study.� Ostomy/Wound Management, U.S. National Library of Medicine, May 2011, www.ncbi.nlm.nih.gov/pubmed/21617262.

Christiansen, Sherry. �The Health Benefits of Roman Chamomile.� Verywell Health, Verywell Health, 14 Jan. 2019, www.verywellhealth.com/roman-chamomile-4571307.

Drummond, Elaine M, et al. �An in Vivo Study Examining the Antiinflammatory Effects of Chamomile, Meadowsweet, and Willow Bark in a Novel Functional Beverage.� Journal of Dietary Supplements, U.S. National Library of Medicine, Dec. 2013, www.ncbi.nlm.nih.gov/pubmed/24237191.

Health Team, eMedicine. �German Chamomile:Uses, Side Effects, Dosage, Interactions & Health Benefits.� EMedicineHealth, EMedicineHealth, 17 Sept. 2019, www.emedicinehealth.com/german_chamomile/vitamins-supplements.htm.

Mao, Jun J, et al. �Long-Term Chamomile (Matricaria Chamomilla L.) Treatment for Generalized Anxiety Disorder: A Randomized Clinical Trial.� Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, U.S. National Library of Medicine, 15 Dec. 2016, www.ncbi.nlm.nih.gov/pubmed/27912875.

Shoara, Ruhollah, et al. �Efficacy and Safety of Topical Matricaria Chamomilla L. (Chamomile) Oil for Knee Osteoarthritis: A Randomized�Controlled Clinical Trial.� Complementary Therapies in Clinical Practice, U.S. National Library of Medicine, Aug. 2015, www.ncbi.nlm.nih.gov/pubmed/26256137.

Singh, Ompal, et al. �Chamomile (Matricaria Chamomilla L.): An Overview.� Pharmacognosy Reviews, Medknow Publications Pvt Ltd, Jan. 2011, www.ncbi.nlm.nih.gov/pmc/articles/PMC3210003/.

Srivastava, Janmejai K, et al. �Chamomile: A Herbal Medicine of the Past with Bright Future.� Molecular Medicine Reports, U.S. National Library of Medicine, 1 Nov. 2010, www.ncbi.nlm.nih.gov/pmc/articles/PMC2995283/.

 

What Chiropractic Patients Want To Know About Curcumin

What Chiropractic Patients Want To Know About Curcumin

Chronic pain is one of the most prevalent conditions in the United States, affecting an estimated 100 million Americans each year. To put that into perspective, that�s more than the number of people suffering from cancer, heart disease, and diabetes, combined.

Many of these chronic pain sufferers are looking for relief beyond pharmaceuticals which can have unpleasant and even harmful side effects. This has brought them to natural pain management methods like chiropractic care as well as natural substances like curcumin. For many people, these treatment options have brought them relief from the pain and help them return to a more normal lifestyle.

How does it work though? And, more importantly, can it work for you?

What is Curcumin?

curcumin for chronic pain el paso tx.
Natural herbal turmeric capsules with fresh herb leaves and dry curcumin in paper

Curcumin is a spice that is a relative of ginger and is a component of turmeric. Often in the U.S., the terms curcumin and turmeric are used interchangeably. However, curcumin is what gives turmeric its bright yellow color.

While it is often found in curries and other traditional Indian food, it has also long been used to treat a variety of health issues including inflammation that causes pain in the body. These claims have been backed up by several studies that show the tasty spice has tremendous health benefits to offer.

These studies have shown that curcumin has strong anti-inflammatory properties although why it works is not yet completely understood. This information has prompted further studies to determine the efficacy of curcumin in treating a wide range of conditions including chronic pain.

One study examined the spice�s effects on people suffering from arthritis or joint pain. The results determined that turmeric extract (curcumin) supplements were just as effective as ibuprofen in relieving the pain in patients with knee osteoarthritis. It helped to reduce the inflammation that was causing the pain, bringing the patients much-needed relief.

Taking Curcumin for Better Health

You can get curcumin or turmeric supplements, but there is no standard dosage information available. Your chiropractor can advise you on how much to take and which supplement brands are the best.

You can also use the spice in the foods you eat and gain a good bit of the health properties that way. However, it may be more efficient and more comfortable to take curcumin or turmeric supplements, especially when you are treating inflammation and pain.

Curcumin is generally safe with very few side effects. As with any medication or supplement, some people are sensitive to the spice and may experience diarrhea and nausea.

However, that usually occurs at higher doses or after the patient has been using it for a long time. High doses could also pose a risk if the person has ulcers. It can also irritate the skin is applied topically.

If you are considering incorporating curcumin into your daily diet as a health supplement, you should first talk to your doctor or chiropractor to make sure it is safe for you. Women who are pregnant or nursing should not take the supplements.

People with conditions like diabetes, gallbladder issues, bleeding disorders, kidney disease, or immunity problems should take special care when using the supplement. Also, it can interact with medications like NSAIDs, aspirin, diabetes drugs, statins, blood thinners, and blood pressure medications so talk to your health professional, such as your chiropractor, before taking. They may adjust your dosage or recommend certain nutritional therapies to better support the supplement.

Your chiropractor can help you live a more natural, pain-free life and supplements like curcumin may be a part of that plan. They can help put you on the path to a life well lived.

Chronic Pain Treatment

What Are The Risks Of Nrf2 Overexpression?

What Are The Risks Of Nrf2 Overexpression?

The nuclear erythroid 2-related factor 2 signaling pathway, best known as Nrf2, is a protective mechanism which functions as a “master regulator” of the human body’s antioxidant response. Nrf2 senses the levels of oxidative stress within the cells and triggers protective antioxidant mechanisms. While Nrf2 activation can have many benefits, Nrf2 “overexpression” can have several risks. It appears that a balanced degree of NRF2 is essential towards preventing the overall development of a variety of diseases in addition to the general improvement of these health issues. However, NRF2 can also cause complications. The main cause behind NRF2 “overexpression” is due to a genetic mutation or a continuing chronic exposure to a chemical or oxidative stress, among others. Below, we will discuss the downsides of Nrf2 overexpression and demonstrate its mechanisms of action within the human body.

Cancer

Research studies found that mice that don’t express NRF2 are more inclined to develop cancer in response to physical and chemical stimulation. Similar research studies, however, showed that NRF2 over-activation, or even KEAP1 inactivation, can result in the exacerbation of certain cancers, particularly if those pathways have been interrupted. Overactive�NRF2 can occur through smoking, where continuous NRF2 activation is believed to be the cause of lung cancer in smokers. Nrf2 overexpression might cause cancerous cells not to self-destruct, while intermittent NRF2 activation can prevent cancerous cells from triggering toxin induction. Additionally, because NRF2 overexpression increases the human body’s antioxidant ability to function beyond redox homeostasis, this boosts cell division and generates an unnatural pattern of DNA and histone methylation. This can ultimately�make�chemotherapy and radiotherapy less effective against cancer. Therefore, limiting NRF2 activation with substances like DIM, Luteolin, Zi Cao, or salinomycin could be ideal for patients with cancer although Nrf2 overactivation should not be considered to be the only cause for cancer. Nutrient deficiencies can affect genes, including NRF2. This might be one way as to how deficiencies contribute to tumors.

Liver

The overactivation of Nrf2, can also affect the function of specific organs in the human body. NRF2 overexpression can ultimately block the production of the insulin-like growth factor 1, or IGF-1, from the liver, which is essential for the regeneration of the liver.

Heart

While the acute overexpression of Nrf2 may have its benefits, continuous overexpression of NRF2 may cause long-term harmful effects on the heart, such as cardiomyopathy. NRF2 expression can be increased through high levels of cholesterol, or the activation of HO-1. This is believed to be the reason why chronic elevated levels of cholesterol might cause cardiovascular health issues.

Vitiligo

NRF2 overexpression has also been demonstrated to inhibit the capability to repigment in vitiligo as it might obstruct Tyrosinase, or TYR, action which is essential for repigmentation through melaninogenesis. Research studies have demonstrated that this process may be one of the primary reasons as to why people with vitiligo don’t seem to activate Nrf2 as efficiently as people without vitiligo.

Why NRF2 May Not Function Properly

Hormesis

NRF2 has to be hormetically activated in order to be able to take advantage of its benefits. In other words, Nrf2 shouldn’t trigger every minute or every day,�therefore, it’s a great idea to take breaks from it, by way of instance, 5 days on 5 days off or every other day. NRF2 must also accomplish a specific threshold to trigger its hormetic response, where a small stressor may not be enough to trigger it.

DJ-1 Oxidation

Protein deglycase DJ-1, or just DJ-1, also called the Parkinson’s disease protein, or PARK7, is a master regulator and detector of the redox status in the human body. DJ-1 is essential towards regulating how long NRF2 can perform its function and produce an antioxidant response. In the case that DJ-1 becomes overoxidized, the cells will make the DJ-1 protein less accessible. This process induces NRF2 activation to expire too fast since DJ-1 is paramount for maintaining balanced levels of NRF2 and preventing them from being broken down in the cell. In case the DJ-1 protein is non-existent or overoxidized, NRF2 expression will probably be minimal, even using DIM or alternative NRF2 activators. DJ-1 expression is imperative to restore impaired NRF2 action.

Chronic Illness

If you have a chronic illness, including CIRS, chronic infections/dysbiosis/SIBO, or heavy metal build up, such as mercury and/or that from root canals, these can obstruct the systems of NRF2 and phase two detoxification. Rather than oxidative stress turning NRF2 into an antioxidant, NRF2 will not trigger and oxidative stress can remain in the cell and cause damage, meaning, there is no antioxidant response. This is a significant reason why many people with CIRS have several sensitivities and reach to numerous factors. Some people believe they may be�having a herx response, however, this reaction may only be damaging the cells farther. Treating chronic illness, however, will permit the liver to discharge toxins into the bile, gradually developing the hormetic response of NRF2 activation. If the bile remains toxic and it’s not excreted from the human body, it will reactivate NRF2’s oxidative stress and cause you to feel worse once it’s reabsorbed from the gastrointestinal, or GI, tract. For example, ochratoxin A may block NRF2. Aside from treating the problem, histone deacetylase inhibitors can block the oxidative reaction from a number of the factors which trigger NRF2 activation but it might also prevent NRF2 from triggerring�normally, which might ultimately fail to serve its purpose.

Fish Oil Dysregulation

Cholinergics are substances which boost acetylcholine, or ACh, and choline in the brain through the increase of ACh, particularly when inhibiting the breakdown of ACh. Patients with CIRS often have problems with the dysregulation of acetylcholine levels in the human body, especially in the brain. Fish oil triggers NRF2, activating its protective antioxidant mechanism within the cells. People with chronic illnesses might have problems with cognitive stress and acetylcholine excitotoxicity, from organophosphate accumulation, which might cause fish oil to create�inflammation within the human body. Choline deficiency additionally induces NRF2 activation. Including choline into your diet, (polyphenols, eggs, etc.) can help enhance the effects of cholinergic dysregulation.

What Decreases NRF2?

Decreasing NRF2 overexpression is best for people that have cancer, although it may be beneficial for a variety of other health issues.

Diet, Supplements, and Common Medicines:

  • Apigenin (higher doses)
  • Brucea javanica
  • Chestnuts
  • EGCG (high doses increase NRF2)
  • Fenugreek (Trigonelline)
  • Hiba (Hinokitiol / ?-thujaplicin)
  • High Salt Diet
  • Luteolin (Celery, green pepper, parsley, perilla leaf, and chamomile tea – higher doses may increase NRF2 – 40 mg/kg luteolin three times per week )
  • Metformin (chronic intake)
  • N-Acetyl-L-Cysteine (NAC, by blocking the oxidative response, esp at high doses)
  • Orange Peel (have polymethoxylated flavonoids)
  • Quercetin (higher doses may increase NRF2 – 50 mg/kg/d quercetin)
  • Salinomycin (drug)
  • Retinol (all-trans retinoic acid)
  • Vitamin C when combined with Quercetin
  • Zi Cao (Purple Gromwel has Shikonin/Alkannin)

Pathways and Other:

  • Bach1
  • BET
  • Biofilms
  • Brusatol
  • Camptothecin
  • DNMT
  • DPP-23
  • EZH2
  • Glucocorticoid Receptor signaling (Dexamethasone and Betamethasone as well)
  • GSK-3? (regulatory feedback)
  • HDAC activation?
  • Halofuginone
  • Homocysteine (ALCAR can reverse this homocysteine induce low levels of NRF2)
  • IL-24
  • Keap1
  • MDA-7
  • NF?B
  • Ochratoxin A(aspergillus and pencicllium species)
  • Promyelocytic leukemia protein
  • p38
  • p53
  • p97
  • Retinoic acid receptor alpha
  • Selenite
  • SYVN1 (Hrd1)
  • STAT3 inhibition (such as Cryptotanshinone)
  • Testosterone (and Testosterone propionate, although TP intranasally may increase NRF2)
  • Trecator (Ethionamide)
  • Trx1 (via reduction of Cys151 in Keap1 or of Cys506 in the NLS region of Nrf2)
  • Trolox
  • Vorinostat
  • Zinc Deficiency (makes it worse in the brain)

Nrf2 Mechanism Of Action

Oxidative stress triggers through CUL3 where NRF2 from KEAP1, a negative inhibitor, subsequently enters the nucleus of these cells, stimulating the transcription of the AREs, turning sulfides into disulfides, and turning them into more antioxidant genes, leading to the upregulation of antioxidants, such as GSH, GPX, GST, SOD, etc.. The rest of these can be seen in the list below:
  • Increases AKR
  • Increases ARE
  • Increases ATF4
  • Increases Bcl-xL
  • Increases Bcl-2
  • Increases BDNF
  • Increases BRCA1
  • Increases c-Jun
  • Increases CAT
  • Increases cGMP
  • Increases CKIP-1
  • Increases CYP450
  • Increases Cul3
  • Increases GCL
  • Increases GCLC
  • Increases GCLM
  • Increases GCS
  • Increases GPx
  • Increases GR
  • Increases GSH
  • Increases GST
  • Increases HIF1
  • Increases HO-1
  • Increases HQO1
  • Increases HSP70
  • Increases IL-4
  • Increases IL-5
  • Increases IL-10
  • Increases IL-13
  • Increases K6
  • Increases K16
  • Increases K17
  • Increases mEH
  • Increases Mrp2-5
  • Increases NADPH
  • Increases Notch 1
  • Increases NQO1
  • Increases PPAR-alpha
  • Increases Prx
  • Increases p62
  • Increases Sesn2
  • Increases Slco1b2
  • Increases sMafs
  • Increases SOD
  • Increases Trx
  • Increases Txn(d)
  • Increases UGT1(A1/6)
  • Increases VEGF
  • Reduces ADAMTS(4/5)
  • Reduces alpha-SMA
  • Reduces ALT
  • Reduces AP1
  • Reduces AST
  • Reduces Bach1
  • Reduces COX-2
  • Reduces DNMT
  • Reduces FASN
  • Reduces FGF
  • Reduces HDAC
  • Reduces IFN-?
  • Reduces IgE
  • Reduces IGF-1
  • Reduces IL-1b
  • Reduces IL-2
  • Reduces IL-6
  • Reduces IL-8
  • Reduces IL-25
  • Reduces IL-33
  • Reduces iNOS
  • Reduces LT
  • Reduces Keap1
  • Reduces MCP-1
  • Reduces MIP-2
  • Reduces MMP-1
  • Reduces MMP-2
  • Reduces MMP-3
  • Reduces MMP-9
  • Reduces MMP-13
  • Reduces NfkB
  • Reduces NO
  • Reduces SIRT1
  • Reduces TGF-b1
  • Reduces TNF-alpha
  • Reduces Tyr
  • Reduces VCAM-1
  • Encoded from the NFE2L2 gene, NRF2, or nuclear erythroid 2-related factor 2, is a transcription factor in the basic leucine zipper, or bZIP, superfamily which utilizes a Cap’n’Collar, or CNC structure.
  • It promotes nitric enzymes, biotransformation enzymes, and xenobiotic efflux transporters.
  • It is an essential regulator at the induction of the phase II antioxidant and detoxification enzyme genes, which protect cells from damage caused by oxidative�stress and electrophilic attacks.
  • During homeostatic conditions, Nrf2 is sequestered in the cytosol through bodily attachment of the N-terminal domain of Nrf2, or the Kelch-like ECH-associated protein or Keap1, also referred to as INrf2 or Inhibitor of Nrf2, inhibiting Nrf2 activation.
  • It may also be controlled by mammalian selenoprotein thioredoxin reductase 1, or TrxR1, which functions as a negative regulator.
  • Upon vulnerability to electrophilic stressors, Nrf2 dissociates from Keap1, translocating into the nucleus, where it then heterodimerizes with a range of transcriptional regulatory protein.
  • Frequent interactions comprise with those of transcription authorities Jun and Fos, which can be members of the activator protein family of transcription factors.
  • After dimerization, these complexes then bind to antioxidant/electrophile responsive components ARE/EpRE and activate transcription, as is true with the Jun-Nrf2 complex, or suppress transcription, much like the Fos-Nrf2 complex.
  • The positioning of the ARE, which is triggered or inhibited, will determine which genes are transcriptionally controlled by these variables.
  • When ARE is triggered:
  1. Activation of the�synthesis of antioxidants is capable of detoxifying ROS like catalase, superoxide-dismutase, or SOD, GSH-peroxidases, GSH-reductase, GSH-transferase, NADPH-quinone oxidoreductase, or NQO1, Cytochrome P450 monooxygenase system, thioredoxin, thioredoxin reductase, and HSP70.
  2. Activation of this GSH synthase permits a noticeable growth of the�GSH intracellular degree, which is quite protective.
  3. The augmentation of this synthesis and degrees of phase II enzymes like UDP-glucuronosyltransferase, N-acetyltransferases, and sulfotransferases.
  4. The upregulation of HO-1, which is a really protective receptor with a potential growth of CO that in conjunction with NO allows vasodilation of ischemic cells.
  5. Reduction of iron overload through elevated ferritin and bilirubin as a lipophilic antioxidant. Both the phase II proteins along with the antioxidants are able to fix the chronic oxidative stress and also to revive a normal redox system.
  • GSK3? under the management of AKT and PI3K, phosphorylates Fyn resulting in Fyn nuclear localization, which Fyn phosphorylates Nrf2Y568 leading to nuclear export and degradation of Nrf2.
  • NRF2 also dampens the TH1/TH17 response and enriches the TH2 response.
  • HDAC inhibitors triggered the Nrf2 signaling pathway and up-regulated that the Nrf2 downstream targets HO-1, NQO1, and glutamate-cysteine ligase catalytic subunit, or GCLC, by curbing Keap1 and encouraging dissociation of Keap1 from Nrf2, Nrf2 nuclear translocation, and Nrf2-ARE binding.
  • Nrf2 includes a half-life of about 20 minutes under basal conditions.
  • Diminishing the IKK? pool through Keap1 binding reduces I?B? degradation and might be the elusive mechanism by which Nrf2 activation is proven to inhibit NF?B activation.
  • Keap1 does not always have to be downregulated to get NRF2 to operate, such as chlorophyllin, blueberry, ellagic acid, astaxanthin, and tea polyphenols may boost NRF2 and KEAP1 at 400 percent.
  • Nrf2 regulates negatively through the term of stearoyl CoA desaturase, or SCD, and citrate lyase, or CL.

Genetics

KEAP1

rs1048290

  • C allele – showed a significant risk for and a protective effect against drug resistant epilepsy (DRE)

rs11085735 (I’m AC)

  • associated with rate of decline of lung function in the LHS

MAPT

rs242561

  • T allele – protective allele for Parkinsonian disorders – had stronger NRF2/sMAF binding and was associated with the higher MAPT mRNA levels in 3 different regions in brain, including cerebellar cortex (CRBL), temporal cortex (TCTX), intralobular white matter (WHMT)

NFE2L2 (NRF2)

rs10183914 (I’m CT)

  • T allele – increased levels of Nrf2 protein and delayed age of onset of Parkinson’s by four years

rs16865105 (I’m AC)

  • C allele – had higher risk of Parkinson’s Disease

rs1806649 (I’m CT)

  • C allele – has been identified and may be relevant for breast cancer etiology.
  • associated with increased risk of hospital admissions during periods of high PM10 levels

rs1962142 (I’m GG)

  • T allele – was associated with a low level of cytoplasmic NRF2 expression (P = 0.036) and negative sulfiredoxin expression (P = 0.042)
  • A allele – protected from forearm blood flow (FEV) decline (forced expiratory volume in one second) in relation to cigarette smoking status (p = 0.004)

rs2001350 (I’m TT)

  • T allele – protected from FEV decline (forced expiratory volume in one second) in relation to cigarette smoking status (p = 0.004)

rs2364722 (I’m AA)

  • A allele – protected from FEV decline (forced expiratory volume in one second) in relation to cigarette smoking status (p = 0.004)

rs2364723

  • C allele – associated with significantly reduced FEV in Japanese smokers with lung cancer

rs2706110

  • G allele – showed a significant risk for and a protective effect against drug resistant epilepsy (DRE)
  • AA alleles – showed significantly reduced KEAP1 expression
  • AA alleles – was associated with an increased risk of breast cancer (P = 0.011)

rs2886161 (I’m TT)

  • T allele – associated with Parkinson’s Disease

rs2886162

  • A allele – was associated with low NRF2 expression (P = 0.011; OR, 1.988; CI, 1.162�3.400) and the AA genotype was associated with a worse survival (P = 0.032; HR, 1.687; CI, 1.047�2.748)

rs35652124 (I’m TT)

  • A allele – associated with higher associated with age at onset for Parkinson’s Disease vs G allele
  • C allele – had increase NRF2 protein
  • T allele – had less NRF2 protein and greater risk of heart disease and blood pressure

rs6706649 (I’m CC)

  • C allele – had lower NRF2 protein and increase risk for Parkinson’s Disease

rs6721961 (I’m GG)

  • T allele – had lower NRF2 protein
  • TT alleles – association between cigarette smoking in heavy smokers and a decrease in semen quality
  • TT allele – was associated with increased risk of breast cancer [P = 0.008; OR, 4.656; confidence interval (CI), 1.350�16.063] and the T allele was associated with a low extent of NRF2 protein expression (P = 0.0003; OR, 2.420; CI, 1.491�3.926) and negative SRXN1 expression (P = 0.047; OR, 1.867; CI = 1.002�3.478)
  • T allele – allele was also nominally associated with ALI-related 28-day mortality following systemic inflammatory response syndrome
  • T allele – protected from FEV decline (forced expiratory volume in one second) in relation to cigarette smoking status (p = 0.004)
  • G allele – associated with increased risk of ALI following major trauma in European and African-Americans (odds ratio, OR 6.44; 95% confidence interval
  • AA alleles – associated with infection-induced asthma
  • AA alleles – exhibited significantly diminished NRF2 gene expression and, consequently, an increased risk of lung cancer, especially those who had ever smoked
  • AA alleles – had a significantly higher risk for developing T2DM (OR 1.77; 95% CI 1.26, 2.49; p = 0.011) relative to those with the CC genotype
  • AA alleles – strong association between wound repair and late toxicities of radiation (associated with a significantly higher risk for developing late effects in African-Americans with a trend in Caucasians)
  • associated with oral estrogen therapy and risk of venous thromboembolism in postmenopausal women

rs6726395 (I’m AG)

  • A allele – protected from FEV1 decline (forced expiratory volume in one second) in relation to cigarette smoking status (p = 0.004)
  • A allele – associated with significantly reduced FEV1 in Japanese smokers with lung cancer
  • GG alleles – had higher NRF2 levels and decreased risk of macular degeneration
  • GG alleles – had higher survival with Cholangiocarcinoma

rs7557529 (I’m CT)

  • C allele – associated with Parkinson’s Disease
Dr Jimenez White Coat
Oxidative stress and other stressors can cause cell damage which may eventually lead to a variety of health issues. Research studies have demonstrated that Nrf2 activation can promote the human body’s protective antioxidant mechanism, however, researchers have discussed that Nrf2 overexpression can have tremendous risks towards overall health and wellness. Various types of cancer can also occur with Nrf2 overactivation. Dr. Alex Jimenez D.C., C.C.S.T. Insight

Sulforaphane and Its Effects on Cancer, Mortality, Aging, Brain and Behavior, Heart Disease & More

Isothiocyanates are some of the most important plant compounds you can get in your diet. In this video I make the most comprehensive case for them that has ever been made. Short attention span? Skip to your favorite topic by clicking one of the time points below. Full timeline below. Key sections:
  • 00:01:14 – Cancer and mortality
  • 00:19:04 – Aging
  • 00:26:30 – Brain and behavior
  • 00:38:06 – Final recap
  • 00:40:27 – Dose
Full timeline:
  • 00:00:34 – Introduction of sulforaphane, a major focus of the video.
  • 00:01:14 – Cruciferous vegetable consumption and reductions in all-cause mortality.
  • 00:02:12 – Prostate cancer risk.
  • 00:02:23 – Bladder cancer risk.
  • 00:02:34 – Lung cancer in smokers risk.
  • 00:02:48 – Breast cancer risk.
  • 00:03:13 – Hypothetical: what if you already have cancer? (interventional)
  • 00:03:35 – Plausible mechanism driving the cancer and mortality associative data.
  • 00:04:38 – Sulforaphane and cancer.
  • 00:05:32 – Animal evidence showing strong effect of broccoli sprout extract on bladder tumor development in rats.
  • 00:06:06 – Effect of direct supplementation of sulforaphane in prostate cancer patients.
  • 00:07:09 – Bioaccumulation of isothiocyanate metabolites in actual breast tissue.
  • 00:08:32 – Inhibition of breast cancer stem cells.
  • 00:08:53 – History lesson: brassicas were established as having health properties even in ancient Rome.
  • 00:09:16 – Sulforaphane’s ability to enhance carcinogen excretion (benzene, acrolein).
  • 00:09:51 – NRF2 as a genetic switch via antioxidant response elements.
  • 00:10:10 – How NRF2 activation enhances carcinogen excretion via glutathione-S-conjugates.
  • 00:10:34 – Brussels sprouts increase glutathione-S-transferase and reduce DNA damage.
  • 00:11:20 – Broccoli sprout drink increases benzene excretion by 61%.
  • 00:13:31 – Broccoli sprout homogenate increases antioxidant enzymes in the upper airway.
  • 00:15:45 – Cruciferous vegetable consumption and heart disease mortality.
  • 00:16:55 – Broccoli sprout powder improves blood lipids and overall heart disease risk in type 2 diabetics.
  • 00:19:04 – Beginning of aging section.
  • 00:19:21 – Sulforaphane-enriched diet enhances lifespan of beetles from 15 to 30% (in certain conditions).
  • 00:20:34 – Importance of low inflammation for longevity.
  • 00:22:05 – Cruciferous vegetables and broccoli sprout powder seem to reduce a wide variety of inflammatory markers in humans.
  • 00:23:40 – Mid-video recap: cancer, aging sections
  • 00:24:14 – Mouse studies suggest sulforaphane might improve adaptive immune function in old age.
  • 00:25:18 – Sulforaphane improved hair growth in a mouse model of balding. Picture at 00:26:10.
  • 00:26:30 – Beginning of brain and behavior section.
  • 00:27:18 – Effect of broccoli sprout extract on autism.
  • 00:27:48 – Effect of glucoraphanin on schizophrenia.
  • 00:28:17 – Start of depression discussion (plausible mechanism and studies).
  • 00:31:21 – Mouse study using 10 different models of stress-induced depression show sulforaphane similarly effective as fluoxetine (prozac).
  • 00:32:00 – Study shows direct ingestion of glucoraphanin in mice is similarly effective at preventing depression from social defeat stress model.
  • 00:33:01 – Beginning of neurodegeneration section.
  • 00:33:30 – Sulforaphane and Alzheimer’s disease.
  • 00:33:44 – Sulforaphane and Parkinson’s disease.
  • 00:33:51 – Sulforaphane and Hungtington’s disease.
  • 00:34:13 – Sulforaphane increases heat shock proteins.
  • 00:34:43 – Beginning of traumatic brain injury section.
  • 00:35:01 – Sulforaphane injected immediately after TBI improves memory (mouse study).
  • 00:35:55 – Sulforaphane and neuronal plasticity.
  • 00:36:32 – Sulforaphane improves learning in model of type II diabetes in mice.
  • 00:37:19 – Sulforaphane and duchenne muscular dystrophy.
  • 00:37:44 – Myostatin inhibition in muscle satellite cells (in vitro).
  • 00:38:06 – Late-video recap: mortality and cancer, DNA damage, oxidative stress and inflammation, benzene excretion, cardiovascular disease, type II diabetes, effects on the brain (depression, autism, schizophrenia, neurodegeneration), NRF2 pathway.
  • 00:40:27 – Thoughts on figuring out a dose of broccoli sprouts or sulforaphane.
  • 00:41:01 – Anecdotes on sprouting at home.
  • 00:43:14 – On cooking temperatures and sulforaphane activity.
  • 00:43:45 – Gut bacteria conversion of sulforaphane from glucoraphanin.
  • 00:44:24 – Supplements work better when combined with active myrosinase from vegetables.
  • 00:44:56 – Cooking techniques and cruciferous vegetables.
  • 00:46:06 – Isothiocyanates as goitrogens.
According to research studies, Nrf2, is a fundamental transcription factor which activates the cells’ protective antioxidant mechanisms to detoxify the human body. The overexpression of Nrf2, however, can cause health issues. The scope of our information is limited to chiropractic and spinal health issues. To discuss the subject matter, please feel free to ask Dr. Jimenez or contact us at�915-850-0900�. Curated by Dr. Alex Jimenez
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Additional Topic Discussion:�Acute Back Pain

Back pain�is one of the most prevalent causes of disability and missed days at work worldwide. Back pain attributes to the second most common reason for doctor office visits, outnumbered only by upper-respiratory infections. Approximately 80 percent of the population will experience back pain at least once throughout their life. The spine is a complex structure made up of bones, joints, ligaments, and muscles, among other soft tissues. Injuries and/or aggravated conditions, such as�herniated discs, can eventually lead to symptoms of back pain. Sports injuries or automobile accident injuries are often the most frequent cause of back pain, however, sometimes the simplest of movements can have painful results. Fortunately, alternative treatment options, such as chiropractic care, can help ease back pain through the use of spinal adjustments and manual manipulations, ultimately improving pain relief.  
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EXTRA EXTRA | IMPORTANT TOPIC: Recommended El Paso, TX Chiropractor

***
The Role Of Nrf2 Activation

The Role Of Nrf2 Activation

Many current research studies on cancer have allowed health professionals to understand the way the body detoxes. By analyzing upregulated genes in tumorous cells, researchers discovered the nuclear erythroid 2-related factor 2 signaling pathway, best known as Nrf2. NRF2 is an important transcription factor which activates the human body’s protective antioxidant mechanisms in order to regulate oxidation from both external and internal factors to prevent increased levels of oxidative stress.

Principles of Nrf2

NRF2 is essential towards maintaining overall health and wellness because it�serves the primary purpose of regulating how we manage everything we’re exposed to on a daily basis and not become sick. NRF2 activation plays a role in the phase II detoxification system.�Phase II detoxification takes lipophilic, or�fat soluble, free radicals and converts them into hydrophilic, or water soluble,�substances for excretion while inactivating exceptionally reactive metabolites and chemicals as a consequence of phase I.

NRF2 activation reduces overall oxidation and inflammation of the human body through a hormetic effect. To trigger NRF2, an inflammatory reaction due to oxidation must occur in order for the cells to produce an adaptive response and create antioxidants, such as glutathione. To break down the principle of Nrf2, essentially, oxidative stress activates NRF2 which then activates an antioxidant response in the human body. NRF2 functions to balance redox signaling, or the equilibrium of oxidant and antioxidant levels in the cell.

A great illustration of how this process functions can be demonstrated with exercise. Through every workout, the muscle adapts so that it can accommodate another workout session. If NRF2 becomes under- or over-expressed due to chronic infections or increased exposure to toxins, which may be observed in patients who have chronic inflammatory response syndrome, or CIRS, the health issues may worsen�following NRF2 activation. Above all, if DJ-1 becomes over-oxidized, NRF2 activation will end�too quickly.

Effects of NRF2 Activation

NRF2 activation is highly expressed in the lungs, liver, and kidneys. Nuclear erythroid 2-related factor 2, or NRF2, most commonly functions by counteracting increased levels of oxidation in the human body which can lead to oxidative stress. Nrf2 activation can help treat a variety of health issues, however, over-activation of Nrf2 may worsen various problems, which are demonstrated below.

Periodic activation of Nrf2 can help:

  • Aging (ie Longevity)
  • Autoimmunity and Overall Inflammation (ie Arthritis, Autism)
  • Cancer and Chemoprotection (ie EMF Exposure)
  • Depression and Anxiety (ie PTSD)
  • Drug Exposure (Alcohol, NSAIDs )
  • Exercise and Endurance Performance
  • Gut Disease (ie SIBO, Dysbiosis, Ulcerative Colitis)
  • Kidney Disease (ie Acute Kidney Injury, Chronic Kidney Disease, Lupus Nephritis)
  • Liver Disease (ie Alcoholic Liver Disease, Acute Hepatitis, Nonalcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis, Cirrhosis)
  • Lung Disease (ie Asthma, Fibrosis)
  • Metabolic And Vascular Disease (ie Atherosclerosis, Hypertension, Stroke, Diabetes)
  • Neurodegeneration (ie Alzheimer’s, Parkinson’s, Huntington’s and ALS)
  • Pain (ie Neuropathy)
  • Skin Disorders (ie Psoriasis, UVB/Sun Protection)
  • Toxin Exposure (Arsenic, Asbestos, Cadmium, Fluoride, Glyphosate, Mercury, Sepsis, Smoke)
  • Vision (ie Bright Light, Sensitivity, Cataracts, Corneal Dystrophy)

Hyperactivation of Nrf2 can worsen:

  • Atherosclerosis
  • Cancer (ie Brain, Breast, Head, Neck Pancreatic, Prostate, Liver, Thyroid)
  • Chronic Inflammatory Response Syndrome (CIRS)
  • Heart Transplant (while open NRF2 may be bad, NRF2 can help with repair)
  • Hepatitis C
  • Nephritis (severe cases)
  • Vitiligo

Furthermore, NRF2 can help make specific nutritional supplements, drugs,�and medications work. Many natural�supplements can also help trigger NRF2. Through current research studies, researchers have demonstrated that a large number of compounds which were once believed to be antioxidants were really pro-oxidants. That’s because nearly all of them need NRF2 to function, even supplements like curcumin and fish oil. Cocoa, for example, was shown to generate antioxidant effects in mice which possess the NRF2 gene.

Ways To Activate NRF2

In the case of neurodegenerative diseases like Alzheimer’s disease, Parkinson’s disease, stroke or even autoimmune diseases, it’s probably best to have Nrf2 upregulated, but in a hormetic fashion. Mixing NRF2 activators may also have an additive or synergistic effect, as occasionally it can be dose-dependent. The top ways to increase Nrf2 expression are listed below:

  • HIST (Exercise) + CoQ10 + Sun (these synergize very well)
  • Broccoli Sprouts + LLLT on my head and gut
  • Butyrate + Super Coffee + Morning Sun
  • Acupuncture (this is an alternative method, laser acupuncture may also be used)
  • Fasting
  • Cannabidiol (CBD)
  • Lion’s Mane + Melatonin
  • Alpha-lipoic acid + DIM
  • Wormwood
  • PPAR-gamma Activation

The following comprehensive listing containing over 350 other ways to activate Nrf2 through diet, lifestyle and devices, probiotics, supplements, herbs and oils, hormones and neurotransmitters, drugs/medications and chemicals, pathways/transcription factors, as well as other ways, is only a brief guide as to what can trigger Nrf2. For the sake of brevity in this article, we have left out over 500 other foods, nutritional supplements and compounds which can help activate Nrf2. The following are listed below:

Diet:

  • Acai Berries
  • Alcohol (Red wine is better, especially if there is a cork in it, as protocatechuic aldehyde from corks can also activate NRF2. In general, alcohol is not recommended, although acute intake increases NRF2. Chronic intake may decrease NRF2.
  • Algae (kelp)
  • Apples
  • Black Tea
  • Brazil Nuts
  • Broccoli Sprouts (and other isothiocyanates, sulforaphane as well as cruciferous vegetables like bok choy that have D3T)
  • Blueberries (0.6-10 g/day)
  • Carrots (falcarinone)
  • Cayenne Pepper (Capsaicin)
  • Celery (Butylphthalide)
  • Chaga (Betulin)
  • Chamomile Tea
  • Chia
  • Chinese Potato
  • Chokeberries (Aronia)
  • Chocolate (Dark or Cocoa)
  • Cinnamon
  • Coffee (such as chlorogenic acid, Cafestol and Kahweol)
  • Cordyceps
  • Fish (and Shellfish)
  • Flaxseed
  • Garlic
  • Ghee (possibly)
  • Ginger (and Cardamonin)
  • Gojiberries
  • Grapefruit (Naringenin – 50 mg/kg/d naringenin)
  • Grapes
  • Green Tea
  • Guava
  • Heart Of Palm
  • Hijiki/Wakame
  • Honeycomb
  • Kiwi
  • Legumes
  • Lion’s Mane
  • Mahuwa
  • Mangos (Mangiferin)
  • Mangosteen
  • Milk (goat, cow – via regulation of microbiome)
  • Mulberries
  • Olive Oil (pomace – hydroxytyrosol and Oleanolic Acid)
  • Omega 6 Fatty Acids (Lipoxin A4)
  • Osange Oranges (Morin)
  • Oyster Mushrooms
  • Papaya
  • Peanuts
  • Pigeon Peas
  • Pomegranate (Punicalagin, Ellagic Acid)
  • Propolis (Pinocembrin)
  • Purple Sweet Potatoes
  • Rambutan (Geraniin)
  • Onions
  • Reishi
  • Rhodiola Rosea (Salidroside)
  • Rice Bran (cycloartenyl ferulate)
  • Riceberry
  • Rooibos Tea
  • Rosemary
  • Sage
  • Safflower
  • Sesame Oil
  • Soy (and isoflavones, Daidzein, Genistein)
  • Squash
  • Strawberries
  • Tartary Buckwheat
  • Thyme
  • Tomatoes
  • Tonka Beans
  • Turmeric
  • Wasabi
  • Watermelon

Lifestyle and Devices:

  • Acupuncture and Electroacupuncture (via collagen cascade on ECM)
  • Blue light
  • Brain Games (increases NRF2 in the hippocampus)
  • Caloric Restriction
  • Cold (showers, plunges, ice bath, gear, cryotheraphy)
  • EMFs (low frequency, such as PEMF)
  • Exercise (Acute exercise like HIST or HIIT seems to be more beneficial for inducing NRF2, while longer exercise doesn�t induce NRF2, but does increase glutathione levels)
  • High Fat Diet (diet)
  • High Heat (Sauna)
  • Hydrogen Inhalation and Hydrogen Water
  • Hyperbaric Oxygen Therapy
  • Infrared Therapy (such as Joovv)
  • Intravenous Vitamin C
  • Ketogenic Diet
  • Ozone
  • Smoking (not recommended – acutely smoking increase NRF2, chronically smoking decreases NRF2. If you choose to smoke, Holy Basil may help protect against downregulation of NRF2)
  • Sun (UVB and Infrared)

Probiotics:

  • Bacillus subtilis (fmbJ)
  • Clostridium butyricum (MIYAIRI 588)
  • Lactobacillus brevis
  • Lactobacillus casei (SC4 and 114001)
  • Lactobacillus collinoides
  • Lactobacillus gasseri (OLL2809, L13-Ia, and SBT2055)
  • Lactobacillus helveticus (NS8)
  • Lactobacillus paracasei (NTU 101)
  • Lactobacillus plantarum (C88, CAI6, FC225, SC4)
  • Lactobacillus rhamnosus (GG)

Supplements, Herbs, and Oils:

  • Acetyl-L-Carnitine (ALCAR) and Carnitine
  • Allicin
  • Alpha-lipoic acid
  • Amentoflavone
  • Andrographis paniculata
  • Agmatine
  • Apigenin
  • Arginine
  • Artichoke (Cyanropicrin)
  • Ashwaganda
  • Astragalus
  • Bacopa
  • Beefsteak (Isogemaketone)
  • Berberine
  • Beta-caryophyllene
  • Bidens Pilosa
  • Black Cumin Seed Oil (Thymoquinone)
  • Boswellia
  • Butein
  • Butyrate
  • Cannabidiol (CBD)
  • Carotenioids (like Beta-carotene [synergy with Lycopene – 2 � 15 mg/d lycopene], Fucoxanthin, Zeaxanthin, Astaxanthin, and Lutein)
  • Chitrak
  • Chlorella
  • Chlorophyll
  • Chrysanthemum zawadskii
  • Cinnamomea
  • Common Sundew
  • Copper
  • Coptis
  • CoQ10
  • Curcumin
  • Damiana
  • Dan Shen/Red Sage (Miltirone)
  • DIM
  • Dioscin
  • Dong Ling Cao
  • Dong Quai (female ginseng)
  • Ecklonia Cava
  • EGCG
  • Elecampane / Inula
  • Eucommia Bark
  • Ferulic Acid
  • Fisetin
  • Fish Oil (DHA/EPA – 3 � 1 g/d fish oil containing 1098 mg EPA and 549 mg DHA)
  • Galangal
  • Gastrodin (Tian Ma)
  • Gentiana
  • Geranium
  • Ginkgo Biloba (Ginkgolide B)
  • Glasswort
  • Gotu Kola
  • Grape Seed Extract
  • Hairy Agrimony
  • Haritaki (Triphala)
  • Hawthorn
  • Helichrysum
  • Henna (Juglone)
  • Hibiscus
  • Higenamine
  • Holy Basil/Tulsi (Ursolic Acid)
  • Hops
  • Horny Goat Weed (Icariin/Icariside)
  • Indigo Naturalis
  • Iron (not recommended unless essential)
  • I3C
  • Job’s Tears
  • Moringa Oleifera (such as Kaempferol)
  • Inchinkoto (combo of Zhi Zi and Wormwood)
  • Kudzu Root
  • Licorice Root
  • Lindera Root
  • Luteolin (high doses for activation, lower doses inhibit NRF2 in cancer though)
  • Magnolia
  • Manjistha
  • Maximowiczianum (Acerogenin A)
  • Mexican Arnica
  • Milk Thistle
  • MitoQ
  • Mu Xiang
  • Mucuna Pruriens
  • Nicotinamide and NAD+
  • Panax Ginseng
  • Passionflower (such as Chrysin, but chyrisin may also reduce NRF2 via dysregulation of PI3K/Akt signaling)
  • Pau d�arco (Lapacho)
  • Phloretin
  • Piceatannol
  • PQQ
  • Procyanidin
  • Pterostilbene
  • Pueraria
  • Quercetin (high doses only, lower doses inhibit NRF2)
  • Qiang Huo
  • Red Clover
  • Resveratrol (Piceid and other phytoestrogens essentially, Knotweed)
  • Rose Hips
  • Rosewood
  • Rutin
  • Sappanwood
  • Sarsaparilla
  • Saururus chinensis
  • SC-E1 (Gypsum, Jasmine, Licorice, Kudzu, and Balloon Flower)
  • Schisandra
  • Self Heal (prunella)
  • Skullcap (Baicalin and Wogonin)
  • Sheep Sorrel
  • Si Wu Tang
  • Sideritis
  • Spikenard (Aralia)
  • Spirulina
  • St. John’s Wort
  • Sulforaphane
  • Sutherlandia
  • Tao Hong Si Wu
  • Taurine
  • Thunder God Vine (Triptolide)
  • Tocopherols (such as Vitamin E or Linalool)
  • Tribulus R
  • Tu Si Zi
  • TUDCA
  • Vitamin A (although other retinoids inhibit NRF2)
  • Vitamin C (high dose only, low dose does inhibit�NRF2)
  • Vitex/Chaste Tree
  • White Peony (Paeoniflorin from Paeonia lactiflora)
  • Wormwood (Hispidulin and Artemisinin)
  • Xiao Yao Wan (Free and Easy Wanderer)
  • Yerba Santa (Eriodictyol)
  • Yuan Zhi (Tenuigenin)
  • Zi Cao (will reduce NRF2 in cancer)
  • Zinc
  • Ziziphus Jujube

Hormones and Neurotransmitters:

  • Adiponectin
  • Adropin
  • Estrogen (but may decrease NRF2 in breast tissue)
  • Melatonin
  • Progesterone
  • Quinolinic Acid (in protective response to prevent excitotoxicity)
  • Serotonin
  • Thyroid Hormones like T3 (can increase NRF2 in healthy cells, but decrease it in cancer)
  • Vitamin D

Drugs/Medications and Chemicals:

  • Acetaminophen
  • Acetazolamide
  • Amlodipine
  • Auranofin
  • Bardoxolone methyl (BARD)
  • Benznidazole
  • BHA
  • CDDO-imidazolide
  • Ceftriaxone (and beta-lactam antibiotics)
  • Cialis
  • Dexamethasone
  • Diprivan (Propofol)
  • Eriodictyol
  • Exendin-4
  • Ezetimibe
  • Fluoride
  • Fumarate
  • HNE (oxidized)
  • Idazoxan
  • Inorganic arsenic and sodium arsenite
  • JQ1 (may inhibit NRF2 as well, unknown)
  • Letairis
  • Melphalan
  • Methazolamide
  • Methylene Blue
  • Nifedipine
  • NSAIDs
  • Oltipraz
  • PPIs (such as Omeprazole and Lansoprazole)
  • Protandim – great results in vivo, but weak/non-existent at activating NRF2 in humans
  • Probucol
  • Rapamycin
  • Reserpine
  • Ruthenium
  • Sitaxentan
  • Statins (such as Lipitor and Simvastatin)
  • Tamoxifen
  • Tang Luo Ning
  • tBHQ
  • Tecfidera (Dimethyl fumarate)
  • THC (not as strong as CBD)
  • Theophylline
  • Umbelliferone
  • Ursodeoxycholic Acid (UDCA)
  • Verapamil
  • Viagra
  • 4-Acetoxyphenol

Pathways/Transcription Factors:

  • ?7 nAChR activation
  • AMPK
  • Bilirubin
  • CDK20
  • CKIP-1
  • CYP2E1
  • EAATs
  • Gankyrin
  • Gremlin
  • GJA1
  • H-ferritin ferroxidase
  • HDAC inhibitors (such as valproic acid and TSA, but can cause NRF2 instability)
  • Heat Shock Proteins
  • IL-17
  • IL-22
  • Klotho
  • let-7 (knocks down mBach1 RNA)
  • MAPK
  • Michael acceptors (most)
  • miR-141
  • miR-153
  • miR-155 (knocks down mBach1 RNA as well)
  • miR-7 (in brain, helps with cancer and schizophrenia)
  • Notch1
  • Oxidatives stress (such as ROS, RNS, H2O2) and Electrophiles
  • PGC-1?
  • PKC-delta
  • PPAR-gamma (synergistic effects)
  • Sigma-1 receptor inhibition
  • SIRT1 (increases NRF2 in the brain and lungs but may decrease it overall)
  • SIRT2
  • SIRT6 (in the liver and brain)
  • SRXN1
  • TrxR1 inhibition (attenuation or depletion as well)
  • Zinc protoporphyrin
  • 4-HHE

Other:

  • Ankaflavin
  • Asbestos
  • Avicins
  • Bacillus amyloliquefaciens (used in agriculture)
  • Carbon Monoxide
  • Daphnetin
  • Glutathione Depletion (depletion of 80%�90% possibly)
  • Gymnaster koraiensis
  • Hepatitis C
  • Herpes (HSV)
  • Indian ash tree
  • Indigowoad Root
  • Isosalipurposide
  • Isorhamentin
  • Monascin
  • Omaveloxolone (strong, aka RTA-408)
  • PDTC
  • Selenium Deficiency (selenium deficiency can increase NRF2)
  • Siberian Larch
  • Sophoraflavanone G
  • Tadehagi triquetrum
  • Toona sinensis (7-DGD)
  • Trumpet Flower
  • 63171 and 63179 (strong)
Dr Jimenez White Coat
The nuclear erythroid 2-related factor 2 signaling pathway, best known by the acronym Nrf2, is a transcription factor which plays the major role of regulating the protective antioxidant mechanisms of the human body, particularly in order to control oxidative stress. While increased levels of oxidative stress can activate Nrf2, its effects are tremendously enhanced through the presence of specific compounds. Certain foods and supplements help activate Nrf2 in the human body, including the isothiocyanate sulforaphane from broccoli sprouts. Dr. Alex Jimenez D.C., C.C.S.T. Insight

Sulforaphane and Its Effects on Cancer, Mortality, Aging, Brain and Behavior, Heart Disease & More

Isothiocyanates are some of the most important plant compounds you can get in your diet. In this video I make the most comprehensive case for them that has ever been made. Short attention span? Skip to your favorite topic by clicking one of the time points below. Full timeline below.

Key sections:

  • 00:01:14 – Cancer and mortality
  • 00:19:04 – Aging
  • 00:26:30 – Brain and behavior
  • 00:38:06 – Final recap
  • 00:40:27 – Dose

Full timeline:

  • 00:00:34 – Introduction of sulforaphane, a major focus of the video.
  • 00:01:14 – Cruciferous vegetable consumption and reductions in all-cause mortality.
  • 00:02:12 – Prostate cancer risk.
  • 00:02:23 – Bladder cancer risk.
  • 00:02:34 – Lung cancer in smokers risk.
  • 00:02:48 – Breast cancer risk.
  • 00:03:13 – Hypothetical: what if you already have cancer? (interventional)
  • 00:03:35 – Plausible mechanism driving the cancer and mortality associative data.
  • 00:04:38 – Sulforaphane and cancer.
  • 00:05:32 – Animal evidence showing strong effect of broccoli sprout extract on bladder tumor development in rats.
  • 00:06:06 – Effect of direct supplementation of sulforaphane in prostate cancer patients.
  • 00:07:09 – Bioaccumulation of isothiocyanate metabolites in actual breast tissue.
  • 00:08:32 – Inhibition of breast cancer stem cells.
  • 00:08:53 – History lesson: brassicas were established as having health properties even in ancient Rome.
  • 00:09:16 – Sulforaphane’s ability to enhance carcinogen excretion (benzene, acrolein).
  • 00:09:51 – NRF2 as a genetic switch via antioxidant response elements.
  • 00:10:10 – How NRF2 activation enhances carcinogen excretion via glutathione-S-conjugates.
  • 00:10:34 – Brussels sprouts increase glutathione-S-transferase and reduce DNA damage.
  • 00:11:20 – Broccoli sprout drink increases benzene excretion by 61%.
  • 00:13:31 – Broccoli sprout homogenate increases antioxidant enzymes in the upper airway.
  • 00:15:45 – Cruciferous vegetable consumption and heart disease mortality.
  • 00:16:55 – Broccoli sprout powder improves blood lipids and overall heart disease risk in type 2 diabetics.
  • 00:19:04 – Beginning of aging section.
  • 00:19:21 – Sulforaphane-enriched diet enhances lifespan of beetles from 15 to 30% (in certain conditions).
  • 00:20:34 – Importance of low inflammation for longevity.
  • 00:22:05 – Cruciferous vegetables and broccoli sprout powder seem to reduce a wide variety of inflammatory markers in humans.
  • 00:23:40 – Mid-video recap: cancer, aging sections
  • 00:24:14 – Mouse studies suggest sulforaphane might improve adaptive immune function in old age.
  • 00:25:18 – Sulforaphane improved hair growth in a mouse model of balding. Picture at 00:26:10.
  • 00:26:30 – Beginning of brain and behavior section.
  • 00:27:18 – Effect of broccoli sprout extract on autism.
  • 00:27:48 – Effect of glucoraphanin on schizophrenia.
  • 00:28:17 – Start of depression discussion (plausible mechanism and studies).
  • 00:31:21 – Mouse study using 10 different models of stress-induced depression show sulforaphane similarly effective as fluoxetine (prozac).
  • 00:32:00 – Study shows direct ingestion of glucoraphanin in mice is similarly effective at preventing depression from social defeat stress model.
  • 00:33:01 – Beginning of neurodegeneration section.
  • 00:33:30 – Sulforaphane and Alzheimer’s disease.
  • 00:33:44 – Sulforaphane and Parkinson’s disease.
  • 00:33:51 – Sulforaphane and Hungtington’s disease.
  • 00:34:13 – Sulforaphane increases heat shock proteins.
  • 00:34:43 – Beginning of traumatic brain injury section.
  • 00:35:01 – Sulforaphane injected immediately after TBI improves memory (mouse study).
  • 00:35:55 – Sulforaphane and neuronal plasticity.
  • 00:36:32 – Sulforaphane improves learning in model of type II diabetes in mice.
  • 00:37:19 – Sulforaphane and duchenne muscular dystrophy.
  • 00:37:44 – Myostatin inhibition in muscle satellite cells (in vitro).
  • 00:38:06 – Late-video recap: mortality and cancer, DNA damage, oxidative stress and inflammation, benzene excretion, cardiovascular disease, type II diabetes, effects on the brain (depression, autism, schizophrenia, neurodegeneration), NRF2 pathway.
  • 00:40:27 – Thoughts on figuring out a dose of broccoli sprouts or sulforaphane.
  • 00:41:01 – Anecdotes on sprouting at home.
  • 00:43:14 – On cooking temperatures and sulforaphane activity.
  • 00:43:45 – Gut bacteria conversion of sulforaphane from glucoraphanin.
  • 00:44:24 – Supplements work better when combined with active myrosinase from vegetables.
  • 00:44:56 – Cooking techniques and cruciferous vegetables.
  • 00:46:06 – Isothiocyanates as goitrogens.

According to many current research studies, the nuclear erythroid 2-related factor 2 signaling pathway, best known as Nrf2, is a fundamental transcription factor which activates the cells’ protective antioxidant mechanisms to detoxify the human body from both external and internal factors and prevent increased levels of oxidative stress. The scope of our information is limited to chiropractic and spinal health issues. To discuss the subject matter, please feel free to ask Dr. Jimenez or contact us at�915-850-0900�.

Curated by Dr. Alex Jimenez

Green Call Now Button H .png

Additional Topic Discussion:�Acute Back Pain

Back pain�is one of the most prevalent causes of disability and missed days at work worldwide. Back pain attributes to the second most common reason for doctor office visits, outnumbered only by upper-respiratory infections. Approximately 80 percent of the population will experience back pain at least once throughout their life. The spine is a complex structure made up of bones, joints, ligaments, and muscles, among other soft tissues. Injuries and/or aggravated conditions, such as�herniated discs, can eventually lead to symptoms of back pain. Sports injuries or automobile accident injuries are often the most frequent cause of back pain, however, sometimes the simplest of movements can have painful results. Fortunately, alternative treatment options, such as chiropractic care, can help ease back pain through the use of spinal adjustments and manual manipulations, ultimately improving pain relief. �

blog picture of cartoon paper boy

EXTRA EXTRA | IMPORTANT TOPIC: Recommended El Paso, TX Chiropractor

***

What Are The Benefits Of Nrf2?

What Are The Benefits Of Nrf2?

Oxidative stress is a major contributor in the development of a variety of health issues, including cancer, heart disease, diabetes, accelerated aging and neurodegeneration. Antioxidant rich foods, herbs and supplements can be utilized to protect the human body from high levels of oxidative stress. Recent research studies have demonstrated that the Nrf2 gene pathway can help amplify the effects of antioxidants. The benefits of Nrf2 are described below.

Protects the Body Against Toxins

NRF2 is an intrinsic substance which can protect the cells from harmful, internal and external compounds. NRF2 may help enrich the human body’s reaction to drugs/medications and toxins, improving the production of�proteins that help eliminate compounds from the cell, known as multidrug resistance-associated proteins, or MRPs.�By way of instance, NRF2 is triggered upon cigarette smoke inhalation to allow the lungs to detox.

Additionally, it is essential for the lungs to protect themselves against allergens, viral diseases, bacterial endotoxins, hyperoxia, and various environmental pollutants. The constant trigger of Nrf2 however, can decrease the levels of a substance known as glutathione throughout the human body. NRF2 may also protect the liver from toxicity and it can protect the liver from arsenic hepatotoxicity. Moreover, NRF2 protects the liver and brain from alcohol consumption. By way of instance, Nrf2 can protect�against acetaminophen toxicity.

Fights Inflammation And Oxidative Stress

NRF2 activation can help battle against inflammation by diminishing inflammatory cytokines, such as those present in psoriasis. NRF2 may also decrease inflammation associated with a variety of health issues like arthritis and fibrosis of the liver, kidney, and lungs. NRF2 may also help control allergies by lowering Th1/Th17 cytokines and raising TH2 cytokines. This can be beneficial for ailments like asthma.

NRF2 additionally protects against cellular damage from blue light�and from UVA/UVB� found in sunlight. Nrf2 deficiencies can make it a whole lot easier to get sunburnt. One rationale behind this is because NRF2 is capable of regulating collagen in response to UV radiation. Advanced Glycation End-Products, or AGEs, contribute to the development of many health issues, including diabetes and neurodegenerative diseases. NRF2 can decrease the oxidative stress of AGEs within the body. NRF2 may also protect the human body from higher levels of heat-based stress.

Enhances Mitochondria And Exercise Performance

NRF2 is a mitochondrial booster. NRF2 activation contributes to a rise in ATP energy for mitochondria, in addition to enhanced use of oxygen, or citrate, and fat. With no NRF2, mitochondria would just have the ability to function with sugar, or glucose, rather than fat. NRF2 is also essential for mitochondria to develop through a process known as biogenesis. NRF2 activation is vital in order to�take advantage of� the benefits of exercise.

Because of�Nrf2’s activity, exercise raises mitochondrial function, where this result may be amplified with CoQ10, Cordyceps, and Caloric Restriction. Moderate exercise or acute exercise induces mitochondrial biogenesis and an elevated synthesis of superoxide dismutase, or SOD, and heme-oxygenase-1, or HO-1, through NRF2 activation. Alpha-Lipoic Acid,�or ALA, and Dan Shen can boost NRF2 mediated mitochondrial biogenesis. Furthermore,�NRF2 can also improve exercise tolerance where NRF2 deletion makes exercise harmful.

Protects Against Hypoxia

NRF2 also helps protect the human body from cellular oxygen loss/depletion, a health issue called hypoxia. Individuals with CIRS have reduced levels of oxygen since their NRF2 is obstructed, resulting in reduced levels of both VEGF, HIF1, and HO-1. Ordinarily, in healthy individuals with hypoxia, miR-101, which is required for the creation of stem cells, are overexpressed and enhance amounts of NRF2/HO-1 and VEGF/eNOS, therefore preventing brain damage, but that does not appear to occur in CIRS.

Hypoxia, characterized by low HIF1, in CIRS can also result in a leaky blood brain barrier due to an NRF2 imbalance. Salidroside, located in the Rhodiola, functions on NRF2 activation and assists with hypoxia by increasing levels of VEGF and HIF1 within the human body. NRF2 can also ultimately protect against lactate buildup in the heart. NRF2 activation may also stop hypoxia-induced Altitude Motion Sickness, or AMS.

Slows Down Aging

Several compounds which may be fatal in massive quantities may increase longevity in rather tiny quantities due to xenohormesis through NRF2, PPAR-gamma, and FOXO. A�very small quantity of toxins raises the cell’s ability to become better equipped for the next time it’s challenged with a toxin, however, this is not an endorsement to consume poisonous�chemicals.

A good illustration of this process is with caloric restriction. NRF2 can improve the lifespan of cells by raising their levels of mitochondria and antioxidants as well as lowering the cells’ capability to die. NRF2 declines with aging because NRF2 prevents stem cells from dying and assists them to�regenerate. NRF2 plays a part in enhancing wound healing.

Boosts the Vascular System

Done correctly with the production of sulforaphane, NRF2 activation may protect against heart diseases like high blood pressure, or hypertension, and hardening of the arteries, or atherosclerosis. NRF2 can enhance Acetylcholine’s, or ACh, relaxing activity on the vascular system whilst reducing cholesterol-induced stress. Nrf2 activation may strengthen the heart, however, over-activated Nrf2 can raise the probability of cardiovascular disease.

Statins may prevent or lead to cardiovascular disease. NRF2 also plays a major part in balancing iron and calcium which may shield the human body from having elevated levels of iron. By way of instance, Sirtuin 2, or SIRT2, can regulate iron homeostasis in cells by activation of NRF2 which is believed to be required for healthy levels of iron. NRF2 can also help with Sickle Cell Disease, or SCD. NRF2 dysfunction might be a reason behind endotoxemia like with dysbiosis or lectins induced hypertension. Nrf2 may also protect the human body against amphetamine induced damage to the vascular system.

Fights Neuroinflammation

NRF2 can shield against and assist with inflammation of the brain, commonly referred to as neuroinflammation. Furthermore, NRF2 can help with an Assortment of Central Nervous System, or CNS, disorders, including:

  • Alzheimer’s Disease (AD) – reduces amyloid beta stress on mitochondria
  • Amyotrophic Lateral Sclerosis (ALS)
  • Huntington’s Disease (HD)
  • Multiple Sclerosis (MS)
  • Nerve Regeneration
  • Parkinson’s disease (PD) – protects dopamine
  • Spinal Cord Injury (SCI)
  • Stroke (ischemic and hemorrhagic) – aids hypoxia
  • Traumatic Brain Injury

NRF2 has revealed a decrease of neuroinflammation in teens with Autism Spectrum Disorders�or ASD. Idebenone pairs properly with NRF2 activators contrary to neuroinflammation. NRF2 may also improve the Blood Brain Barrier,�or BBB. By way of instance, NRF2 activation with carnosic acid obtained from rosemary and sage can cross the BBB and cause neurogenesis. NRF2 has also been demonstrated to raise�Brain Derived Neurotrophic Factor, or BDNF.

NRF2 also modulates some nutritional supplements capacity to cause Nerve Growth Factor, or NGF as it� can also aid with brain fog and glutamate-induced issues by modulating N-Methyl-D-Aspartate,�or NMDA receptors. It may also lower the oxidative stress from quinolinic acid, referred to as QUIN. NRF2 activation can protect against seizures and large doses can decrease the brink of a seizure. At regular doses of stimulation, NRF2 can enhance cognitive abilities following a seizure by lowering extracellular glutamate in the brain and by it’s ability to draw cysteine from glutamate and glutathione.

Relieves Depression

In depression, it’s normal to notice inflammation in the brain, especially from the prefrontal cortex and hippocampus, as well as decreased BDNF. In some versions of depression, NRF2 can improve depressive symptoms by lowering inflammation within the brain and increasing BDNF levels. Agmatine’s capability to decrease depression by raising noradrenaline, dopamine, serotonin, and BDNF in the hippocampus depends upon NRF2 activation.

Contains Anti-Cancer Properties

NRF2 is equally a tumor suppressor as it is a tumor promoter if not managed accordingly. NRF2 can protect against cancer caused by free radicals and oxidative stress, however, NRF2 overexpression can be found in cancer cells as well. Intense activation of NRF2 can assist with a variety of cancers. By way of instance, the supplement Protandim can reduce skin cancer by NRF2 activation.

Relieves Pain

Gulf War Illness, or GWI, a notable illness affecting Gulf War Veterans, is a collection of unexplained, chronic symptoms which may include tiredness, headaches, joint pain, indigestion, insomnia, dizziness, respiratory ailments, and memory issues. NRF2 can improve symptoms of GWI by diminishing hippocampal and general inflammation, in addition to decreasing pain. NRF2 can additionally assist with pain from bodily nerve injury and improve nerve damage from diabetic neuropathy.

Improves Diabetes

High glucose levels, best referred to as hyperglycemia, causes oxidative damage to the cells due to the disruption of mitochondrial function. NRF2 activation may shield the human body against hyperglycemia’s harm to the cell, thereby preventing cell death. NRF2 activation can additionally protect, restore, and enhance pancreatic beta-cell function, while reducing insulin resistance.

Protects Vision And Hearing

NRF2 can protect against harm to the eye from diabetic retinopathy. It might also avoid the formation of cataracts and protect photoreceptors contrary to light-induced death. NRF2 additionally shield the ear, or cochlea, from stress and hearing loss.

Might Help Obesity

NRF2 may help with obesity primarily due to its capacity to regulate variables that operate on fat accumulation in the human body. NRF2 activation with sulforaphane can raise inhibit of Fatty Acid Synthesis, or FAS, and Uncoupling Proteins, or UCP, resulting in less fat accumulation and more brown fat, characterized as fat which includes more mitochondria.

Protects The Gut

NRF2 helps protect the gut by safeguarding the intestine microbiome homeostasis. By way of instance, lactobacillus probiotics will trigger NRF2 to guard the gut from oxidative stress. NRF2 can also help prevent Ulcerative Colitis, or UC.

Protects Sex Organs

NRF2 can shield the testicles and keep sperm count from harm in people with diabetes. It can also assist with Erectile Dysfunction, or ED. Some libido boosting supplements like Mucuna, Tribulus, and Ashwaganda�may enhance�sexual function via NRF2 activation. Other factors that boost NRF2, such as sunlight or broccoli sprouts, can also help improve libido.

Regulates Bones And Muscles

Oxidative stress may result in bone density and strength reduction, which is normal in osteoporosis. NRF2 activation could have the ability to improve antioxidants in bones and protect against bone aging. NRF2 can also prevent muscle loss and enhance Duchenne Muscular Dystrophy, or DMD.

Contains Anti-Viral Properties

Last but not least, NRF2 activation can ultimately help defend the human body against several viruses. In patients with the dengue virus, symptoms were not as intense in individuals who had greater levels of NRF2 compared to individuals who had less degrees of NRF2. NRF2 can also help people who have Human Immunodeficiency-1 Virus,�or HIV. NRF2 can protect against the oxidative stress from Adeno-Associated Virus,�or AAV, and H. Pylori. Finally, Lindera Root may suppress Hepatitis C virus with NRF2 activation.

Dr Jimenez White Coat
Nrf2, or NF-E2-related factor 2, is a transcription factor found in humans which regulates the expression of a specific set of antioxidant and detoxifying genes. This signaling pathway is activated due to oxidative stress as it enhances numerous antioxidant and phase II liver detoxification enzymes to restore homeostasis in the human body. Humans are adapted to function throughout a state of homeostasis or balance. When the body is confronted with oxidative stress, Nrf2 activates to regulate oxidation and control the stress it causes. Nrf2 is essential to prevent health issues associated with oxidative stress. Dr. Alex Jimenez D.C., C.C.S.T. Insight

Sulforaphane and Its Effects on Cancer, Mortality, Aging, Brain and Behavior, Heart Disease & More

Isothiocyanates are some of the most important plant compounds you can get in your diet. In this video I make the most comprehensive case for them that has ever been made. Short attention span? Skip to your favorite topic by clicking one of the time points below. Full timeline below.

Key sections:

  • 00:01:14 – Cancer and mortality
  • 00:19:04 – Aging
  • 00:26:30 – Brain and behavior
  • 00:38:06 – Final recap
  • 00:40:27 – Dose

Full timeline:

  • 00:00:34 – Introduction of sulforaphane, a major focus of the video.
  • 00:01:14 – Cruciferous vegetable consumption and reductions in all-cause mortality.
  • 00:02:12 – Prostate cancer risk.
  • 00:02:23 – Bladder cancer risk.
  • 00:02:34 – Lung cancer in smokers risk.
  • 00:02:48 – Breast cancer risk.
  • 00:03:13 – Hypothetical: what if you already have cancer? (interventional)
  • 00:03:35 – Plausible mechanism driving the cancer and mortality associative data.
  • 00:04:38 – Sulforaphane and cancer.
  • 00:05:32 – Animal evidence showing strong effect of broccoli sprout extract on bladder tumor development in rats.
  • 00:06:06 – Effect of direct supplementation of sulforaphane in prostate cancer patients.
  • 00:07:09 – Bioaccumulation of isothiocyanate metabolites in actual breast tissue.
  • 00:08:32 – Inhibition of breast cancer stem cells.
  • 00:08:53 – History lesson: brassicas were established as having health properties even in ancient Rome.
  • 00:09:16 – Sulforaphane’s ability to enhance carcinogen excretion (benzene, acrolein).
  • 00:09:51 – NRF2 as a genetic switch via antioxidant response elements.
  • 00:10:10 – How NRF2 activation enhances carcinogen excretion via glutathione-S-conjugates.
  • 00:10:34 – Brussels sprouts increase glutathione-S-transferase and reduce DNA damage.
  • 00:11:20 – Broccoli sprout drink increases benzene excretion by 61%.
  • 00:13:31 – Broccoli sprout homogenate increases antioxidant enzymes in the upper airway.
  • 00:15:45 – Cruciferous vegetable consumption and heart disease mortality.
  • 00:16:55 – Broccoli sprout powder improves blood lipids and overall heart disease risk in type 2 diabetics.
  • 00:19:04 – Beginning of aging section.
  • 00:19:21 – Sulforaphane-enriched diet enhances lifespan of beetles from 15 to 30% (in certain conditions).
  • 00:20:34 – Importance of low inflammation for longevity.
  • 00:22:05 – Cruciferous vegetables and broccoli sprout powder seem to reduce a wide variety of inflammatory markers in humans.
  • 00:23:40 – Mid-video recap: cancer, aging sections
  • 00:24:14 – Mouse studies suggest sulforaphane might improve adaptive immune function in old age.
  • 00:25:18 – Sulforaphane improved hair growth in a mouse model of balding. Picture at 00:26:10.
  • 00:26:30 – Beginning of brain and behavior section.
  • 00:27:18 – Effect of broccoli sprout extract on autism.
  • 00:27:48 – Effect of glucoraphanin on schizophrenia.
  • 00:28:17 – Start of depression discussion (plausible mechanism and studies).
  • 00:31:21 – Mouse study using 10 different models of stress-induced depression show sulforaphane similarly effective as fluoxetine (prozac).
  • 00:32:00 – Study shows direct ingestion of glucoraphanin in mice is similarly effective at preventing depression from social defeat stress model.
  • 00:33:01 – Beginning of neurodegeneration section.
  • 00:33:30 – Sulforaphane and Alzheimer’s disease.
  • 00:33:44 – Sulforaphane and Parkinson’s disease.
  • 00:33:51 – Sulforaphane and Hungtington’s disease.
  • 00:34:13 – Sulforaphane increases heat shock proteins.
  • 00:34:43 – Beginning of traumatic brain injury section.
  • 00:35:01 – Sulforaphane injected immediately after TBI improves memory (mouse study).
  • 00:35:55 – Sulforaphane and neuronal plasticity.
  • 00:36:32 – Sulforaphane improves learning in model of type II diabetes in mice.
  • 00:37:19 – Sulforaphane and duchenne muscular dystrophy.
  • 00:37:44 – Myostatin inhibition in muscle satellite cells (in vitro).
  • 00:38:06 – Late-video recap: mortality and cancer, DNA damage, oxidative stress and inflammation, benzene excretion, cardiovascular disease, type II diabetes, effects on the brain (depression, autism, schizophrenia, neurodegeneration), NRF2 pathway.
  • 00:40:27 – Thoughts on figuring out a dose of broccoli sprouts or sulforaphane.
  • 00:41:01 – Anecdotes on sprouting at home.
  • 00:43:14 – On cooking temperatures and sulforaphane activity.
  • 00:43:45 – Gut bacteria conversion of sulforaphane from glucoraphanin.
  • 00:44:24 – Supplements work better when combined with active myrosinase from vegetables.
  • 00:44:56 – Cooking techniques and cruciferous vegetables.
  • 00:46:06 – Isothiocyanates as goitrogens.

When the human body is confronted with harmful internal and external factors like toxins, the cells must rapidly trigger their antioxidant abilities to counteract oxidative stress. Because increased levels of oxidative stress have been determined to cause a variety of health issues, it’s important to use Nrf2 activation to take advantage of its benefits. The scope of our information is limited to chiropractic and spinal health issues. To discuss the subject matter, please feel free to ask Dr. Jimenez or contact us at�915-850-0900�.

Curated by Dr. Alex Jimenez

Green Call Now Button H .png

Additional Topic Discussion:�Acute Back Pain

Back pain�is one of the most prevalent causes of disability and missed days at work worldwide. Back pain attributes to the second most common reason for doctor office visits, outnumbered only by upper-respiratory infections. Approximately 80 percent of the population will experience back pain at least once throughout their life. The spine is a complex structure made up of bones, joints, ligaments, and muscles, among other soft tissues. Because of this, injuries and/or aggravated conditions, such as�herniated discs, can eventually lead to symptoms of back pain. Sports injuries or automobile accident injuries are often the most frequent cause of back pain, however, sometimes the simplest of movements can have painful results. Fortunately, alternative treatment options, such as chiropractic care, can help ease back pain through the use of spinal adjustments and manual manipulations, ultimately improving pain relief. �

blog picture of cartoon paper boy

EXTRA EXTRA | IMPORTANT TOPIC: Recommended El Paso, TX Chiropractor

***

Maintaining Healthy Blood Sugar Levels

Maintaining Healthy Blood Sugar Levels

For people struggling to control their blood glucose levels, the most common concern is, how can you regulate blood sugar levels? Maintaining healthy blood sugar levels can be complicated and unyielding. Along with food and beverages, our blood sugar levels fluctuate in response to a huge variety of unique factors. Exercise, psychological stress, the previous night’s rest, and genetics all play a role in the human body’s effort to closely regulate the degree of glucose circulating in the blood. Additionally, no matter whether or not somebody has a blood glucose dysregulation problem or full-blown diabetes, that morning meal we call breakfast actually sets the stage for your day.

 

What is often known as the “Dawn Phenomenon” occurs between 4:00 AM to 8:00 AM when the human body produces sufficient amounts of glucagon, cortisol and epinephrine to boost blood glucose as a natural procedure before waking up in the morning. And science supports those people who prefer to eat a hearty breakfast as soon as they wake up. One study that monitored the sugar profiles of healthy people during the day saw that the largest increase in blood glucose occurs right after breakfast. Just about every nutritionist, dietitian and endocrinologist recommends eating a high-protein breakfast so as to restrain the naturally-occurring spike in sugar during the daytime. As mentioned previously, these meals, as well as other variables, will dictate the difference in blood glucose levels throughout the day, which directly impacts the way the human body works and an individual’s overall awareness of their health and wellness.

 

When Maintaining Healthy Blood Sugar Levels is Difficult

 

A consistently higher blood sugar level has a deleterious impact on organ function. Risks for diabetes, further heart disease, stroke, kidney disorders, vision impairment and cardiovascular issues that can result in infections and amputation of recurrence increase when blood sugar is uncontrolled. Intense oscillations in blood sugar may stem from many hormonal imbalances, specifically where there is a lack of insulin manufacturing, as in the case of type I diabetes, or an inability to use insulin correctly, commonly referred to as insulin resistance. Either type of diabetes is recognized and monitored with many evaluations, but the most prevalent one is the HbA1C. As a mark of longer-term glucose levels, the HbA1C suggests the average proportion of the particular hemoglobin subtype A1C that has glucose bound to it, glycated or glycosylated, producing a glycoprotein. Since hemoglobin cells normally die off after 120 days, this process firmly reflects the typical plasma glucose level over in the past 90 days. This diagnostic tool proves more helpful than a diagram of blood sugar, which shows great vacillations through the day. Individuals with diabetes or more lengths of hyperglycemia, as noticed in patients diagnosed with metabolic syndrome, have increased HbA1C levels. It’s projected that in 2015 over 7 million cases of diabetes and insulin resistance went undiagnosed. The famed incidence of those conditions is alarming as the trend is nearing 10 percent of the populace.

 

Regulating Blood Glucose Levels with Nutrition

 

Though genetics�are not something people can control, nutrition, diet and other lifestyle variables are within your reach. Eating a balanced diet of low-glycemic, high fiber, and also low-saturated fat meals is recommended for individuals with glycemic control health issues. Combining foods which contain all three macronutrients, such as proteins, fats, and carbohydrates, can also be valuable in regulating blood glucose levels. This list of foods provides a wonderful start to a healthy diet and a platform for preventing those wild swings in sugar throughout the day:

 

  • All colors and varieties of fresh fruits and vegetables
  • Legumes, such as kidney beans, black beans, chickpeas, and lentils
  • Whole grains, such as brown rice, quinoa, barley, and millet
  • Olive oil
  • Tomatoes
  • Fermented, organic and raw dairy
  • Cold-water wild fish, such as salmon, mackerel and sardines
  • Tempeh, tofu and natto
  • Cage-free, organic eggs
  • Green and black tea

 

Supplemental nutrients and botanicals to help encourage wholesome glucose levels and supply a hypoglycemic effect are currently being studied and comprise of:

 

  • Magnesium
  • Chromium, as chromium picolinate
  • Vanadium
  • Alpha lipoic acid
  • Gymnema sylvestre
  • Fenugreek
  • Bitter melon
  • Cinnamon
  • Berberine

 

Berberine functions on multiple fronts. It was found to substantially improve glucose levels by an average of 9.5 percent down to 7.5 percent, as effective as metformin from 9.15 percent down to 7.7 percent, in a research study to find out its effectiveness and safety in type 2 diabetes patients. Furthermore, it had the effect of enhancing both entire cholesterol and low-density lipoprotein cholesterol in the evaluation and analysis.

 

Dr-Jimenez_White-Coat_01.png

Dr. Alex Jimenez’s Insight

Diabetes has become one of the fastest growing diseases in the United States, where it is prevalent among both children and adults. With the increase in cases each year, the numbers of individuals seeking treatment and a potential cure are also rising. Fortunately, research studies have found that maintaining healthy blood sugar levels can help stabilize a case of diabetes. Proper nutrition, as well as natural remedies and botanicals, including alternative treatment options, such as chiropractic care, have been determined to help regulate healthy blood glucose levels, improving an individual’s quality of life.

 

While there are many other ways in which healthy blood sugar levels can be achieved, recent research studies have also determined that chiropractic care may be able to control blood sugar levels, potentially regulating type 2 diabetes. According to these, the key to managing blood glucose levels can be found in the connection between the central nervous system and blood sugar levels in the human body. Chiropractic care focuses on the use of spinal adjustments and manual manipulations to correct spinal misalignments, or subluxations. It has been demonstrated that spinal misalignments, or subluxations, can interfere with important communications signals from the brain to the spinal chords as well as the rest of the body. By carefully restoring the natural integrity of the spine, chiropractors can help regulate healthy blood sugar levels and improve overall health and wellness.

 

Other Important Lifestyle Factors

 

 

To remain steady on what could be a roller coaster ride of blood sugars, a high priority should be given to a well-balanced diet plan, replete with proper nutrition and supplementation, and the close observation of lifestyle and genetic aspects. The scope of our information is limited to chiropractic as well as to spinal injuries and conditions. To discuss the subject matter, please feel free to ask Dr. Jimenez or contact us at�915-850-0900�.

 

Curated by Dr. Alex Jimenez

 

Green-Call-Now-Button-24H-150x150-2-3.png

 

Additional Topics: Back Pain

Back pain is one of the most prevalent causes for disability and missed days at work worldwide. As a matter of fact, back pain has been attributed as the second most common reason for doctor office visits, outnumbered only by upper-respiratory infections. Approximately 80 percent of the population will experience some type of back pain at least once throughout their life. The spine is a complex structure made up of bones, joints, ligaments and muscles, among other soft tissues. Because of this, injuries and/or aggravated conditions, such as herniated discs, can eventually lead to symptoms of back pain. Sports injuries or automobile accident injuries are often the most frequent cause of back pain, however, sometimes the simplest of movements can have painful results. Fortunately, alternative treatment options, such as chiropractic care, can help ease back pain through the use of spinal adjustments and manual manipulations, ultimately improving pain relief.

 

 

 

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EXTRA IMPORTANT TOPIC: Low Back Pain Management

 

MORE TOPICS: EXTRA EXTRA:�Chronic Pain & Treatments

 

Curcumin Boosts Brain Health

Curcumin Boosts Brain Health

How important is nutrition for our brain health? In the current work force, we are continuously stressed, often forced to finish tasks faster in order to meet ever so demanding deadlines. In addition, we are expected to maintain our optimal mental health, as this can be an essential�part towards delivering quality work. When our mental health is being affected by our hectic lifestyles, however, several practices which can help you start thinking more clearly can include sleeping properly, controlling stress, and even taking nutritional supplements for your brain health.

 

One nutritional supplement which has been widely recognized for its ability to boost brain health is curcumin, the active ingredient found in turmeric. Well-known for its antioxidant properties and its capacity to control inflammation in the human body, this powerful herb can also promote good mood and cognition. Another specific group which has reported significant benefits with the increased use of curcumin, is the elderly population. Below, we will discuss how curcumin can help boost brain health as well as demonstrate additional benefits this golden gem can have on our overall health and wellness.

 

Curcumin: a Golden Gem for Brain Health

 

In accordance with the Journal of Pharmacology, curcumin is made-up of a variety of substances which can encourage biological mechanisms that counteract age-related cognitive decline, dementia, or mood disorders. One randomized, double-blind, placebo-controlled trial analyzed the acute, of approximately 1 and 3 hours following a single dose, chronic, of approximately 4 weeks, and acute-on-chronic, of approximately 1 and 3 hours after one dose subsequently after chronic treatment, consequences of a curcumin formulation on cognitive function, mood, and blood biomarkers in 60 healthy adults ranging from the 60 to 85 years of age. After about one hour of application, the curcumin had considerably enhanced the participant’s functionality on attention and working memory tasks, in comparison with the placebo. Working memory and mood, which included general fatigue, change in calmness, contentedness and fatigue triggered by emotional strain were fundamentally improved following chronic therapy.

 

Curcumin boosts BDNF (brain-derived neurotrophic factor), the brain hormone which helps boost the development of new neurons that are in charge of improving memory and learning as well as supplying a substantial option for countering the aging brain. Additionally, this powerful ingredient increases blood circulation to the brain, also providing a much better attention span for greater work productivity.

 

Appreciating its anxiolytic effects can be one of the greatest benefits of carrying curcumin. According to the Journal of Clinical Psychopharmacology, a randomized double-blinded and double-blind trial with 60 subjects experiencing stress-related symptoms, including exhaustion, were to get routine curcumin nutritional supplements, and placebo for 30 days. The results indicated a greater quality of life, and diminished stress and fatigue for those receiving regular curcumin intakes. This progressive compound is believed to be able to help alleviate depression by altering the release of dopamine and serotonin, two powerful hormones which help keep the human mind and body at ease. Curcumin also promotes the optima health and wellness of inflammation pathways from the brain, which ultimately will help improve energy, mood, and production levels.

 

Curcumin may additionally promote cognition via its powerful antioxidant action which improves the bioavailability of DHA, the potent omega-3 fatty acid demonstrated to boost brain health. A research study in the American Journal of Geriatric Psychiatry revealed that curcumin really does protect the brain from neurodegeneration. The evaluation and analysis included 40 participants ranging from the ages of 51 to 84 years of age. Each individual subject consumed 90mg of curcumin twice per day or placebo for 18 weeks. The results indicated enhanced long-term healing, visual memory, and focus. With its tremendous medicinal properties, curcumin can also support neuroplasticity, which empowers the brain to change and fortify itself even through the natural degeneration with aging.

 

Curcumin can also promote anti-seizure action. With its antioxidant properties, this golden gem can help slow down reactive astrocyte expression, which helps cells survive within the mind. According to the Neuropharmacology Laboratory, Department of Pharmacology, the antioxidant properties of curcumin helped alleviate migraines, cognitive impairment, and cognitive stress in rats. A dental pre-treatment of curcumin was given to male rats which were additionally treated together with Pentylenetrazole, or PZT, every other day. The study demonstrated that curcumin enhanced the seizure score and indicated a diminished amount of myoclonic jerks. Furthermore, the outcome measures of the research study demonstrated that curcumin restructures seizures, oxidative stress, and brain function. Moreover, it helps protect memory function which may also be jeopardized by seizure activity.

 

Using its capability to strengthen fatty acids in the mind, curcumin helps athletes achieve better physical performance by boosting critical thinking, improving problem solving, and developing improved choices. The neuroprotective properties in curcumin also help regenerate tissues. In reality, based on Stem Cell Research and Therapy, a research study was conducted between the effects of curcumin on endogenous stem cells which were impartial. The study demonstrated that curcumin played an essential role in the healing of cells from combating the activation of microglia cells. Scientists in the Institute of Neuroscience and Medicine in Julich, Germany, observed the effects of impartial stem cell generation. During a 72-hour period, the evaluation and analysis demonstrated and indicated that the turmeric curcumin improved cellular generation by up to 80 percent. This shows how powerful curcumin could be for successful brain health function.

 

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Dr. Alex Jimenez’s Insight

Nutrition is a fundamental factor in overall health and wellness. In today’s stressful world, however, it can often become difficult to eat a proper meal, let alone making sure we are taking in all the necessary nutrients we require on a regular basis. That, plus the added pressure of the workforce can have detrimental effects on our brain health. Dietary supplements, such as curcumin, have been demonstrated to have tremendous benefits on brain health. Although we may not always have the “free time” to sit down and have a properly balanced meal, taking nutritional supplements like curcumin, among others, can help improve the human body’s general well-being.

 

While many research studies have found that natural remedies and botanicals, such as dietary supplements apart from vitamins and minerals, continue to be the most common complementary health approach in the United States today, more and more alternative treatment options, such as chiropractic care, have started to incorporate these into their practices. As a matter of fact, a majority of chiropractors give nutritional advice, as well as recommendations for other lifestyle recommendations, as a general part of their treatment plan. Because chiropractic care is based on the notion of naturally treating the human body as a whole, enhancing it’s own healing properties without the use of drugs and/or medications as well as other invasive procedures, this healthcare profession relies on offering the necessary health maintenance components for optimal health and wellness. These components can include nutrition, water, rest, exercise, and clean air. Many chiropractors also offer curcumin supplements to help promote recovery.

 

This exceptional nutritional supplement, curcumin, helps improve mental clarity, improve cognition, improve endurance, and supplies anxiolytic benefits. Whether it’s more work fabricating, or a much better disposition, curcumin is a hidden golden gem for health.�The scope of our information is limited to chiropractic as well as to spinal injuries and conditions. To discuss the subject matter, please feel free to ask Dr. Jimenez or contact us at�915-850-0900�.

 

Curated by Dr. Alex Jimenez

 

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Additional Topics: Back Pain

Back pain is one of the most prevalent causes for disability and missed days at work worldwide. As a matter of fact, back pain has been attributed as the second most common reason for doctor office visits, outnumbered only by upper-respiratory infections. Approximately 80 percent of the population will experience some type of back pain at least once throughout their life. The spine is a complex structure made up of bones, joints, ligaments and muscles, among other soft tissues. Because of this, injuries and/or aggravated conditions, such as herniated discs, can eventually lead to symptoms of back pain. Sports injuries or automobile accident injuries are often the most frequent cause of back pain, however, sometimes the simplest of movements can have painful results. Fortunately, alternative treatment options, such as chiropractic care, can help ease back pain through the use of spinal adjustments and manual manipulations, ultimately improving pain relief.

 

 

 

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EXTRA IMPORTANT TOPIC: Low Back Pain Management

 

MORE TOPICS: EXTRA EXTRA:�Chronic Pain & Treatments

 

Naturally Enhancing the Gut-Brain-Heart Connection

Naturally Enhancing the Gut-Brain-Heart Connection

A majority of individuals today are aware about the gut-brain connection and how approximately 90 percent of their body’s serotonin is really generated in the gastrointestinal, or GI, tract as well as the way the gut-brain axis is associated with depression. Overall gut health involving a healthy population of gut microbiota can affect many facets of our well-being, therefore, it’s no mystery that the connection between the gut and chronic health issues, such as cardiovascular disease, diabetes and neurodegenerative diseases, are also significantly strong.

 

Berberine, an ancient mixture frequently utilized in a variety of medicinal herbs throughout several traditional treatments has been demonstrated to benefit as well as link the gut and the heart. Berberine is an isoquinoline derivative alkaloid found in numerous herbs. Although these berberine-containing herbs aren’t traditionally utilized in food preparations, the active ingredient has been identified and may be isolated from a variety of plant sources, such as Coptis chinensis, or Coptis or Goldthread, Hydrastis canadensis, or goldenseal, Berberis aquifolium, or Oregon grape, Berberis aristata, or Tree Turmeric, Berberis vulgaris, or Barberry, and Arcangelisia flava.

 

Berberine is most favorably known for its function in gut health, demonstrating activity which can help support gut microbial balance. In fact, scientists have shown a growing interest in many plant-derived compounds which affect bacterial direction and berberine is a pioneer in the group. Additionally, its a botanical proven to influence blood glucose, blood lipids and also the immune system. Researchers today have learned how berberine can provide these tremendous benefits.

 

Gut Health Equals Heart Health

 

According to evidence from a 2016 research study, the gut’s immune system is fundamental towards preventing a variety of diseases and it may often contribute to metabolic disorders. However, it might also help provide a treatment goal when observing systemic inflammation in insulin resistance. Moreover, modified gut immunity has been linked with changes to the gut microbiota, intestinal barrier function, gut-residing immune cells, and resistance to antigens which enter the gastrointestinal, or GI, system. Although this has been previously believed to raise the danger of esophageal ailments including, pathogenic infections and chronic inflammation, which may ultimately lead to chronic health issues.

 

In our currently hectic and stressful world, a growth in the numbers of chronic disease has begun to negatively affect our overall health health. The best instance of this increase in chronic illness is type 2 diabetes, abbreviated in this article as T2DM, which often coexists with hypertension and causes individuals to pursue nutritional advice in order to achieve healthy blood sugar levels. The information viewing T2DM alone are shocking. As of 2015, the Center for Disease Control and Prevention reported that over 30 million people in the United States had diabetes, where approximately three times as many had pre-diabetes. According to statistics, 70 percent of individuals with pre-diabetes will develop type 2 diabetes.

 

Natural remedies and botanicals utilized as herbal treatments which have been previously used to promote healthy blood sugar levels have been strongly evaluated in order to determine their safety and effectiveness. Numerous berberine research studies are being conducted, though these are mostly in vitro, or in cell cultures. A majority of in vivo research studies have used animals for the analysis. Despite the quality and size of those research studies, virtually all of the outcome measures throughout the last two decades are positive. One research study from 2012 looked at in vitro results to thoroughly assess the assumed mechanism of action by which berberine affects fat storage. The outcome measures using clinical therapeutics of berberine to observe participants with metabolic syndrome appeared promising.

 

Another research study evaluated and analyzed the use of berberine in human cell cultures to ascertain how it influenced preadipocyte, a precursor to fat cells, comparison and fat hormone as well as cell activity in patients with metabolic disease. The researchers demonstrated that preadipocyte differentiation was restricted by berberine, while leptin, adiponectin, PPAR?2, or the nuclear receptor known as the master regulator of fat cell biology and target of many diabetes drugs and/or medications, and C/EBP?, a protein necessary for fat cell differentiation, diminished. After several months, participants demonstrated a drop in their BMI and leptin/adiponectin ratio, showing that berberine could boost insulin sensitivity by limiting fat storage, which may also have beneficial effects in the regulation of blood lipid levels.

 

Concerning how berberine affects cardiovascular biomarkers, many assessments can be found in the literature. The administration of berberine in one analysis generated a substantial decrease in total cholesterol, triglycerides, and low-density lipoprotein cholesterol levels, with a marked rise in high-density lipoprotein. Furthermore, a meta-analysis of this anti-diabetic, hypolipidemic and anti-inflammatory effects of berberine were reviewed in twenty-seven randomized controlled clinical trials. The researchers have concluded that berberine is safe and effective due to its support of the cardiovascular system and the maintenance of healthy blood sugar levels, without any severe adverse reactions found in some of the other research studies. Berberine has also been demonstrated to restrict complex I of the mitochondrial respiratory chain, leading to a growth of 5′ adenosine monophosphate, or AMP and 5′ adenosine monophosphate-activated protein kinase, or AMPK activation. This seems to have a direct impact on energy metabolism as well as that in other structures and functions.

 

The neurological health effects of berberine have also been considered, particularly from the modulation of the dopaminergic system. Berberine has also demonstrated a possibility in the successful management of seizures, diabetes-induced memory malfunction and hyperexcitability. One animal research study investigating obsessive-compulsive disease found that berberine can promote anti-compulsive and/or anxiolytic effects because of its ability to boost brain monoamine levels. Another review from 2016 demonstrated berberine’s ability to reduce oxidative stress and supply neuroprotective benefits. The review further cites research studies which examine the botanical’s function in the evolution of amyloid plaques and intracellular neurofibrillary tangles. Berberine has found its function in the gastrointestinal, cardiovascular as well as brain worlds. Truly offering a wholesome dose of gut-heart-brain link, berberine is definitely one to consider.

 

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Dr. Alex Jimenez’s Insight

Research studies have found that the relationship between a healthy gut, brain and heart is fundamental towards overall well-being. Natural remedies and botanicals, such as berberine, can help promote as well as support this gut-brain-heart connection, while other alternative treatment options, such as chiropractic care, can restore balance and encourage the human body’s natural healing abilities by correcting spinal misalignments of the spine. Furthermore, by establishing the proper relationship between the brain, the spinal chord and the rest of the body, chiropractic care can help regulate the proper structure and function of each system in the human body.

 

With the increasing number of gut health issues, it’s become a priority to find safe and effective treatment options to properly address these common problems. More and more research studies have found a connection between the gut, brain and heart. As previously mentioned, by both supporting and promoting the well-being of the gastrointestinal, or GI, system, the structure and function of a variety of other systems can be sustained. Natural remedies and botanicals, such as berberine, have been utilized for centuries as herbal treatments, however, other alternative treatment options can also be used to help improve gut health. Chiropractic care is a well-known, alternative treatment option which has been demonstrated to help promote the natural healing of the human body through the use of spinal adjustments and manual manipulations as well as other therapeutic techniques to correct spinal misalignments, or subluxations. Moreover, a doctor of chiropractic, or chiropractor, can recommend a series of lifestyle modifications, including exercise and nutritional advice, in order to help further improve the overall health and wellness of the human body. Maintaining the well-being of the gut can help boost brain and heart health as well.

 

Berberine Warnings

 

In large doses, berberine may lead to gastrointestinal irritation. Thus, it’s typically administered in divided doses and taken with a meal. In addition, researchers have revealed that berberine can limit particular cytochrome enzymes that also target a lot of different kinds of drugs and/or medications, including certain antibiotics. Inhibiting cytochrome enzymes influences the liver’s detoxification system, which will be required to metabolize and, finally, clear drugs and/or medications. For this reason, it’s essential to carefully monitor those patients that are using berberine if other medicines are used concomitantly. The scope of our information is limited to chiropractic as well as to spinal injuries and conditions. To discuss the subject matter, please feel free to ask Dr. Jimenez or contact us at�915-850-0900�.

 

Curated by Dr. Alex Jimenez

 

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Additional Topics: Back Pain

Back pain is one of the most prevalent causes for disability and missed days at work worldwide. As a matter of fact, back pain has been attributed as the second most common reason for doctor office visits, outnumbered only by upper-respiratory infections. Approximately 80 percent of the population will experience some type of back pain at least once throughout their life. The spine is a complex structure made up of bones, joints, ligaments and muscles, among other soft tissues. Because of this, injuries and/or aggravated conditions, such as herniated discs, can eventually lead to symptoms of back pain. Sports injuries or automobile accident injuries are often the most frequent cause of back pain, however, sometimes the simplest of movements can have painful results. Fortunately, alternative treatment options, such as chiropractic care, can help ease back pain through the use of spinal adjustments and manual manipulations, ultimately improving pain relief.

 

 

 

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EXTRA IMPORTANT TOPIC: Low Back Pain Management

 

MORE TOPICS: EXTRA EXTRA:�Chronic Pain & Treatments

 

Natural Remedies and Botanicals to Promote Sleep

Natural Remedies and Botanicals to Promote Sleep

Envision yourself waking up entirely rested, prepared to deal with any obstacle and adopt all the joys of the world with gratitude. The majority of us know what a good night’s sleep resembles, but are we really getting the proper rest we should be getting? Within this stressful universe, it’s tough to achieve the sleep schedule that our brains and bodies require to operate to its fullest potential.

 

Proper sleep hygiene and the application of organic herbs and botanicals can help promote a healthy amount of sleep. The outcome could result in a wide array of benefits, including an improvement in problem solving and work performance, weight management, and even promote the prevention of chronic health issues, such as diabetes, cardiovascular disease and mood disorders like depression. You may find numerous products and information regarding how to manage proper sleep. A research study from 2016 indicated that individuals in the United States alone spent over $41 billion on sleeping treatments, where it is expected to rise up to $52 billion by the year 2020.

 

How Much Sleep Do People Need?

 

As you may anticipate, children need more sleep than adults. The average child requires approximately 11 hours of sleep each night, where most adults only require about 7 to 8 hours of sleep each night. However, according to the Center for Disease Control, people in the US only get 6.8 hours of sleep each night. While this may not seem like a huge difference, collectively, the average person is not reaching the minimal amount of sleep of 7 hours, and as a result, your overall health and wellness may suffer. Sleep deprivation is one of the most common behaviors affecting our well-being. Several factors can contribute to this modern lack of proper sleep, including: work schedules, household obligations, and chronic health issues or behavioral challenges. In the majority of these scenarios, our circadian rhythms are entirely out of whack.

 

What Natural Remedies or Botanicals Can Help Promote Sleep?

 

The�German Commission E, globally recognized for its understanding information on the role of medicinal herbs, additionally recommends the frequent utilization of certain botanicals, such as valerian, lavender, lemon balm, and hops, to promote the right level of relaxation and support proper sleep. There are several other well-known options which have sedative qualities, such as passion flower, chamomile, and kava kava. Nearly all of those relaxant natural remedies and botanicals are available commonly in teas, but they are also found in supplement form. Nearly always found in specialized mixes, these herbs have various mechanisms of action, and, therefore, behave synergistically when mixed together.

 

Valerian (Valeriana officinalis) can alter sleep because of its capacity to interact with neurotransmitters GABA, adenosine and serotonin. A two-week randomized controlled trial research study analyzing the differences in which the sleep aid zolpidem, or Ambien, using a mix of valerian, passion flower and hops, demonstrated no statistically significant change in sleep quality. The root or rhizome of the plant is generally utilized in either teas or it is typically processed into an extract to be utilized in nutritional supplements. The extract is standardized into the valerenic acid compound, often made up to 0.3 to 0.8percent of the substance itself. Doses of the herb can be found in nutritional supplements to be ranging from 150 to 600 mg. The use of valerian generally needs to be given about 2 weeks time until its effects begin to affect the individual, however, research studies are limited to 4 to 6 weeks, therefore, its use past that time frame should be approached with care.

 

Lavender (Lavandula angustifolia) is a very popular floral herb utilized in fundamental oil form, teas, extracts and in other botanical combinations to promote relaxation as well as to relieve stress and anxiety. Recent research studies have identified that lavender works by antagonizing NMDA-receptors and serotonin transporters. Doses of about 80 milligrams every day of lavender from gel cap type for up to ten weeks were utilized in a research study where participants had previously been diagnosed with an unspecified type anxiety disorder. Both quality and length of sleep seemed to have been enhanced in those subjects without them experiencing the sedative side-effects as demonstrated in pharmaceutical sleep treatments. Other uses of lavender include 1 to 2 tsp in hot water as a tea every day, or its key oil diluted in a carrier oil used for massage or in a hot bath. Lavender is generally considered safe, however it’s also believed to be toxic if ingested orally in large quantities.

 

Lemon balm (Melissa officinalis) has long been utilized as an antiviral and stomach-calming compound in addition to being used as a treatment for sleep disorders brought on by anxiety or stress. Various research studies have demonstrated that the mechanism of action of lemon balm may be associated with its interaction to GABA-A receptors within the human body.

 

Hops (Humulus lupulus), aside from its frequently enjoyable pronunciation and serving as the main ingredient in a variety of beers, this is one of the herbs which is most commonly mixed in teas or supplements to achieve as well as maintain an overall calming effect. Researchers haven’t completely discovered how hops causes this effect, however, it’s been demonstrated to bind to serotonin and melatonin receptors. Valerian-hops blend products have also become the most widely researched in placebo-controlled, double-blind randomized controlled trials comparing them to benzodiazepine-class sleep drugs and/or medications with varying results. Like lemon balm, signs for its use as a herbal treatment for relaxation or insomnia includes an extended background in history.

 

Passionflower (Passiflora incarnata) is basically another botanical utilized to remedy stress, anxiety and insomnia. Researchers have discovered that passionflower works by increasing levels of GABA, achieving a comforting effect. In a Japanese research study from 2017, scientists discovered that passionflower extract modulates the amounts of the receptors as well as the genetic expression of the related enzymes in vivo and in vitro. This ultimately resulted in favorable effects on circadian rhythms.

 

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Dr. Alex Jimenez’s Insight

Natural remedies and botanicals are a natural option for promoting sleep. While various herbs taken in numerous forms can help provide a good night’s rest, other alternative treatment options can also be considered to get you through a full night of rest. Chiropractic care can help promote sleep by carefully correcting spinal misalignments, or subluxations, through spinal adjustments and manual manipulations, among other techniques. Spinal misalignments, or subluxations, can cause tension and stress along the back, causing pain and discomfort which can contribute to poor sleep. Regular chiropractic care can solve a variety of health issues which may be causing you sleepless nights, thus helping you sleep better and improving quality of life.

 

Proper Sleep Hygiene Advice

 

Dr. Michael Polsky, a board-certified sleep physician, recommends contemplating proper sleep hygiene for improving sleep. Sleep hygiene is a phrase utilized to refer to how we prepare our bodies and minds for sleep, beginning hours before we actually have to sleep. In fact, the window of 2 to 3 hours before sleeping proves to be significantly the most essential when attempting to get a good night’s rest. Below, are several notes of advice for achieving and maintaining proper sleep hygiene:

 

  • At least 2-3 hours before bedtime, have a light, balanced meal and also reduce fluids
  • Make a strategy to avoid the use of electronic devices 1 to 2 hours before bed
  • Do a little mild activity, like walking or yoga; avoid a hard workout or some other action which is too stimulating
  • Reduce or eliminate caffeine, commonly from coffee, tea, or chocolate, drink no more than 1 to 2 cups of coffee or tea before lunch
  • Keep a regular sleep schedule, even on weekends

 

A Simple Tea Recipe

 

Blend a batch of 2 parts peppermint leaf, 1 piece lemon balm, 1 part passionflower, and 1 part lavender. Steep one heaping teaspoon in a teacup of hot water for 5 minutes and enjoy only as a relaxing drink.

 

Sleep deprivation is one of the most common behaviors which can lead to a variety of health issues. While the natural remedies and botanicals mentioned above can be utilized to help promote sleep, other alternative treatment options, such as chiropractic care, have been reported to help provide a better good night’s rest. Chiropractic care focuses on the diagnosis, treatment and prevention of a variety of musculoskeletal and nervous system injuries and/or conditions, through the use of spinal adjustments and manual manipulations. A spinal misalignment, or subluxation, can cause pain and discomfort when trying to get proper sleep. Through chiropractic care, a chiropractor can help promote sleep by carefully correcting any spinal misalignment which may be causing painful symptoms. By treating symptoms of pain and discomfort, chiropractic care can help promote sleep, naturally, without the need for drugs and/or medications as well as surgical interventions.

 

In conclusion, proper sleep and rest are essential elements towards achieving and maintaining overall health and wellness. Through the use of natural remedies and botanicals, by practicing good sleep hygiene tips, and by receiving chiropractic care, the average American can begin to experience the benefits of proper sleep. The scope of our information is limited to chiropractic as well as to spinal injuries and conditions. To discuss the subject matter, please feel free to ask Dr. Jimenez or contact us at�915-850-0900�.

 

Curated by Dr. Alex Jimenez

 

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Additional Topics: Back Pain

Back pain is one of the most prevalent causes for disability and missed days at work worldwide. As a matter of fact, back pain has been attributed as the second most common reason for doctor office visits, outnumbered only by upper-respiratory infections. Approximately 80 percent of the population will experience some type of back pain at least once throughout their life. The spine is a complex structure made up of bones, joints, ligaments and muscles, among other soft tissues. Because of this, injuries and/or aggravated conditions, such as herniated discs, can eventually lead to symptoms of back pain. Sports injuries or automobile accident injuries are often the most frequent cause of back pain, however, sometimes the simplest of movements can have painful results. Fortunately, alternative treatment options, such as chiropractic care, can help ease back pain through the use of spinal adjustments and manual manipulations, ultimately improving pain relief.

 

 

 

blog picture of cartoon paperboy big news

 

EXTRA IMPORTANT TOPIC: Low Back Pain Management

 

MORE TOPICS: EXTRA EXTRA:�Chronic Pain & Treatments

 

What is Meriva Curcumin Phytosome?

What is Meriva Curcumin Phytosome?

Curcumin is the main active ingredient found in turmeric, a bright yellow aromatic powder obtained from the rhizome of a plant in the ginger family commonly utilized for flavoring and coloring in a variety of Asian cuisines, as well as a very strong antioxidant which additionally has powerful anti-inflammatory effects. While turmeric has been consumed for generations due to its medicinal properties, it’s curcumin content is actually not that high. Therefore, if you want to experience its full benefits, it may be best to take a supplement that contains significant amounts of curcumin, or better yet, a supplement specially formulated to bring out the benefits of this naturally occurring chemical compound.

 

Curcumin is ultimately found in turmeric, the key ingredient in curry, and as a powerful antioxidant that offers numerous health benefits, curcumin helps support joint health and cardiovascular function, and it helps maintain a normal inflammatory reaction in the human body. Individuals throughout Asia have benefited from the healthful effects of curcumin for centuries.�Whether taken as a nutritional supplement or from meals, however, curcumin is usually poorly absorbed into the bloodstream.

 

Fortunately, global experts in botanical extract technologies have uncovered the key to curcumin absorption: phytosome technology. Meriva curcumin phytosome is an exceptional curcumin extract that’s significantly better absorbed than other curcumin extracts. Curcumin nutrients which have previously been remarkable in “test tube” experiments are extremely poorly absorbed when taken orally by people. The product Curcumin Phytosome comprising Meriva� unites curcumin with another bioactive nutrient, thereby dramatically improving its absorption and releasing its overall health and wellness potential.�Meriva is a unique, patented, time-release curcumin product.

 

Meriva Product Overview

 

Phytosomes are plant extracts bound to phosphatidylcholine, or PC, an important component of individual cells. The human body can create PC, or phosphatidylcholine, but it can even be obtained from food and/or supplements. When taken orally, PC is very well absorbed.�PC is a significant building block for membranes, the most metabolically dynamic zones of our cells. PC most likely transfers the curcumins in the bloodstream until they arrive in cell membranes. Researchers found a way to attach a curcumin extract to PC for superior absorption, leading to Meriva.�Curcumin phytosome is a curcumin molecule bonded to a molecule of PC. Unlike curcumin alone, PC is excellently absorbed orally.

 

When consumers utilize Meriva curcumin phytosome, the body absorbs the PC as well as the attached curcumin, leading to more curcumin reaching the cells which can benefit more from it. After the curcumin phytosomes are accepted as a dietary supplement, PC protects its connected curcumin and economically transports it across the intestinal lining and into the circulating blood. Curcumins at phytosomes are over 29 times better absorbed than curcumin alone. PC itself has proven benefits for the liver, intestines, and lungs, and its existence in the Meriva curcumin phytosome amplifies the benefits available from the curcumin alone.

 

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Dr. Alex Jimenez’s Insight

Turmeric contains four major curcuminoids: curcumin, demethoxycurcumin, bisdemethoxycurcumin and cyclocurcumin. These chemical compounds have been demonstrated to have tremendous benefits, which is why turmeric has been a fundamental addition in Asian cooking. However, curcumin, as well as all the other curcuminoids, are poorly absorbed by the human body when taken orally. Researchers developed Meriva curcumin phytosome, a curcumin compound which is bonded to the molecule phosphatidylcholine, or PC, which promotes the proper absorption of curcumin. Meriva curcumin phytosome can provide a variety of health benefits, including vision and eye health, joint health and even prostrate benefits, among other medicinal properties.

 

Meriva Curcumin Phytosome Research

 

Curcumin phytosome with Meriva� is a powerful antioxidant which protects cells and tissues by fighting free radicals. It’s also known to support healthy joint function, eye health and small vessel circulatory health. The curcumin is extracted from turmeric and provides a curcumin complex including, curcumin, bisdemethoxy curcumin and demethoxy curcumin. Meriva� curcumin phytosome is made utilizing the patented Phytosome� technology that enhances the absorption of those curcumins. Comprehensive research over the previous quarter of a century suggests that curcumin helps counter toxins, in addition to influencing cell survival through other means.

 

Although curcumins are poorly absorbed, Phytosome� technology helps improve bioavailability. The technology evolves every curcumin molecule with one or more atoms of the nutrient phosphatidylcholine, or PC, to create molecular complexes called phytosomes. Curcumin molecules at the Meriva� phytosome complexes are more stable against breakdown and combine far better into water in order for them to be better absorbed when taken orally. The PC molecules in the phytosomes serve as a “delivery vehicle” or even “chaperone”, which not only chemically protects the curcumin molecules but also markedly increases their absorption. A human absorption research discovered that the curcumins were absorbed when taken as Meriva� curcumin phytosomes, in comparison to their basic molecular forms.

 

The numerous beneficial effects attributed to turmeric root are linked to the antioxidant properties of the curcumins it contains. This antioxidant activity can neutralize free radicals which threaten the integrity of mobile structures. Free radicals may lead to “oxidative stress,” a process that can activate cell damage. In addition, oxidative stress is considered to play a role in the development of a variety of diseases. Because curcumins are poorly absorbed when taken orally, this can tremendously restrict their biological actions. The Phytosome� technology used with Meriva� curcumin phytosome creates phytosome complexes which are proven to be absorbed better.

 

A 2007 study published in the journal, Cancer Chemotherapy and Pharmacology, revealed Meriva’s exceptional bioavailability in contrast to ordinary curcumin. Liver levels of curcumin were also higher with Meriva supplementation. A recent human research study also demonstrated that Meriva curcumin phytosome has 29-times higher bioavailability. Meriva supplementation also resulted in higher plasma concentrations of curcumin from a much smaller dose compared to ordinary curcumin. In a recent eight-month human trial, Meriva was shown to encourage a healthy inflammatory reaction. People experienced improvements in clinical and biochemical end-points associated with joint health.

 

Several studies have shown curcumin’s hepatoprotective effects, causing researchers to suggest its use in protecting the liver from exogenous insults due to environmental toxins. Curcumin also has the capacity to increase both the circulation and solubility of bile. Curcumin’s hepatoprotective effects are due in part to lead free-radical scavenging; however, curcumin also enhances the body’s natural antioxidant system, which raises glutathione levels, thus aiding in hepatic detoxification and inhibiting nitrosamine formation. Furthermore, research studies have demonstrated several other health benefits of Meriva curcumin phytosome, including its support in joint health, eye health, vision and circulation, as well as several prostrate benefits, among others.

 

Meriva Properties Graph | El Paso, TX Chiropractor

 

Supports Joint Health – Two Clinical Trials

 

In two double-blind trials with subjects having knee problems, Meriva, taken at about 1,000 mg/day, enhanced treadmill walk space by 345 percent after eight months. It improved joint pain, stiffness, swelling and joint work. Intakes of over-the-counter medications fell 63 percent and their adverse effects dropped by 67 percent. The subjects’ medical prices fell 45 percent after 8 months. C-Reactive Protein, or CRP, levels were reduced into a more healthy variety. After eight months, the Karnofsky Scale of well-being moved into “able to perform ordinary activity.”

 

Supports Eye Health, Vision, Circulation – Three Clinical Trials

 

One frequent eye problem is a really persistent redness that keeps coming back even when it is cleared. At a clinical trial, 106 patients obtained Meriva, taken at about 1,200 mg/day, for a single year. There were 86 percent fewer returns of this reddening, and in 82 percent of these patients, approximately 87 from 106, it didn’t return at all. In another study, Meriva, taken at about 1,000 mg/day, improved retinal blood circulation, retinal swelling, and eyesight. In only four weeks, visual sharpness improved from an initial average of 20/122-155 to 20/32-78. Meriva also improved circulation elsewhere in the body. In areas with foot blood circulation issues, it substantially reduced immunity, increased oxygen consumption, and enhanced nerve control over the capillary networks. The subjects’ Karnofsky Score of well-being improved, from “normal activity, with effort” into “normal activity.”

 

Breakthrough Prostate Benefits with Meriva

 

In a clinical trial on middle-aged men with prostate troubles, Meriva, taken at 1,000 mg/day, significantly enhanced: sense of incomplete bladder emptying, urination frequency, flow stop/start, feeble stream, straining and getting up at night, urinary block, and PSA levels. Quality of life and sexual activity were also considerably improved. The Meriva curcumin phytosome breakthrough guarantees that curcumins are effectively delivered to human cells, in functional mix with PC, or phosphatidylcholine. Multiple effective clinical trials have established curcumin phytosome comprising of Meriva� as the “gold standard” one of curcumin supplements.

 

In conclusion,�Meriva curcumin phytosome is bound to phosphatidylcholine, or PC, for increased absorption and bioavailability, ultimately protecting DNA against damage by free radicals and reactive oxygen species, among providing a variety of other health benefits. With its enhanced absorption through an improved curcumin absorb delivery system, Meriva curcumin phytosome is clinically documented to promote joint health, eye health, vision and circulation, and even has prostrate benefits. The scope of our information is limited to chiropractic as well as to spinal injuries and conditions. To discuss the subject matter, please feel free to ask Dr. Jimenez or contact us at�915-850-0900�.

 

Curated by Dr. Alex Jimenez

 

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Additional Topics: Back Pain

Back pain is one of the most prevalent causes for disability and missed days at work worldwide. As a matter of fact, back pain has been attributed as the second most common reason for doctor office visits, outnumbered only by upper-respiratory infections. Approximately 80 percent of the population will experience some type of back pain at least once throughout their life. The spine is a complex structure made up of bones, joints, ligaments and muscles, among other soft tissues. Because of this, injuries and/or aggravated conditions, such as herniated discs, can eventually lead to symptoms of back pain. Sports injuries or automobile accident injuries are often the most frequent cause of back pain, however, sometimes the simplest of movements can have painful results. Fortunately, alternative treatment options, such as chiropractic care, can help ease back pain through the use of spinal adjustments and manual manipulations, ultimately improving pain relief.

 

 

 

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EXTRA IMPORTANT TOPIC: Low Back Pain Management

 

MORE TOPICS: EXTRA EXTRA:�Chronic Pain & Treatments

 

CBD – Cannabidiol’s Life Changing Properties

CBD – Cannabidiol’s Life Changing Properties

CBD�research currently being conducted is showing its medical potential. This has opened doors for antipsychotic, anticancer and anti-inflammatory�treatment options among a variety of others. Scientists from all over are publishing studies that are proving CBD is one of the most effective and favorable cannabinoids that promotes proper function of the body’s systems.

Five Properties Of CBD

CBD Medical Benefits

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1. Inhibits Cancer Cell Growth

Studies have supported this claim. By way of Proapoptotic action or apoptosis, Cannabidiol, Tetrahydrocannabinol, Cannabigerol and Cannabichromene�in this order are extremely effective in tumor growth reduction in rats and cancerous human prostate cells. Research is still ongoing, but understanding that these cannabinoids stimulate the body�s process of killing cells that no longer function properly or at their optimal level. In traditional chemotherapy both�healthy and cancerous cells�are destroyed and only works when the cancer cells are replicating more frequently than healthy cells. CBD treatment promotes the body�s natural immune response to cells that are not functioning properly, which eradicates tumors.

2. Pain Reducer

The most common reason people start using marijuana despite its psychoactive affects, is that it also functions, as a pain reliever! People with chronic pain that are tired of taking pain killing opiates, rely on cannabinoid products to deal with pain and eliminate its source, commonly inflammation. Inflammation is the body�s natural response to injury, which floods the injured area with blood and nutrients to aid in rehabilitation. But inflammation creates secondary problems, among them�pain and discomfort. Through stimulation of nutrients in the area that is injured, CBD creates negative feedback to inflammatory reactions, as the nutrients that came with the inflammation are already there.

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3. Treats Anxiety

Anxiety along with PTSD affects over 40 million adults in the U.S. Valium and Xanax is what is normally used to treat these conditions. However, CBD products are becoming the preferred treatment, as they have none of the side effects or dependency issues. The effects of CBD have been observed thoroughly by experts and studies have proved its effectiveness, as a dependable alternative for mental disorders. Two receptors in the human brain responsible for sending out Adrenaline and Serotonin are the�?2-adrenergic receptor agonist and 5-HT1A receptor antagonist. These receptors both are related to anxiety, depression, insomnia, and other mental disorders when imbalanced.

4. Strengthens The Immune System

Phytocannabinoids are able to balance, reinforce and strengthen the immune system. Cannabinoid products taken daily, work in regulating the immune system. This increases the body�s detection of foreign and potentially dangerous organisms, which include cancer cells.

5. Prevents Muscle Spasms

CBD contains�chemically antispasmodic properties. Athletes from all sports love CBD and what it can do. It is a preferred supplement and these oils have proven to prevent muscle spasms and soreness. This is done through�lubricating the potassium and calcium pumps within the muscle tissue.

CBD is finding its place, slowly, but surely. It is one of natures own medicines and it is our job to discover and figure how to utilize these properties. Consult a doctor before beginning any treatment of diagnosed or undiagnosed diseases with CBD. For the more severe diseases like diabetes, schizophrenia, epilepsy, which, CBD can treat, but only when used properly.

Medical Benefits

cbd - cannabidiol el paso tx.