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Hormone Balance

Hormone Balance. Hormones like estrogen, testosterone, adrenaline, and insulin are vital chemical messengers that affect many aspects of one’s health. Hormones are secreted by various glands and organs, including the thyroid, adrenals, pituitary, ovaries, testicles, and pancreas. The entire endocrine system works together to control the level of hormones circulating throughout the body. And if one or more is imbalanced, it can cause major health problems.

The most common symptoms of hormone imbalance include:

  • Infertility and irregular periods
  • Weight gain or weight loss (unexplained, not due to intentional changes in one’s diet)
  • Depression and anxiety
  • Fatigue
  • Insomnia
  • Low libido
  • Appetite changes
  • Issues with digestion
  • Hair thinning and loss

Symptoms of hormonal imbalances can range depending on what type of disorder or illness they cause. For example, symptoms of diabetes include weight gain, appetite changes, nerve damage, and eyesight problems. Conventional treatments for hormone imbalances include synthetic hormone replacement therapies, i.e., insulin injections, thyroid medications.

However, with these types of treatments comes negative effects, such as medication dependency, serious side effects like stroke, osteoporosis, anxiety, reproductive problems, cancer, and more. And with these synthetic treatments, the symptoms aren’t treated but only masked.

Fortunately, there are ways to acquire hormone balance naturally. For example, stay away from oils high in omega-6 fats (safflower, sunflower, corn, canola, soybean, and peanut). Instead, utilize rich sources of natural omega-3’s (wild fish, flaxseed, chia seeds, walnuts, and grass-fed animal products).


Hypothyroidism May Affect More Than The Thyroid

Hypothyroidism May Affect More Than The Thyroid

Introduction

The body is a functional being with the brain to control the host’s movements when going to places or resting, the immune system to battle viruses that enter the body, digest food through the gut system, and the endocrine system regulate hormones that maintain the body. The thyroid secretes hormones out and has a vital role in the body’s functionality, and when it gets affected, it can cause issues associated with the body. When the thyroid doesn’t produce more hormones in the body, it can be at risk of developing hypothyroidism. Today’s article looks at the thyroid’s role in the body, how hypothyroidism affects the body, and how to manage hypothyroidism in the body. We refer patients to certified providers specializing in endocrinology treatments to help many individuals with hypothyroidism. We also guide our patients by referring to our associated medical providers based on their examination when it’s appropriate. We find that education is the solution to asking our providers insightful questions. Dr. Alex Jimenez DC provides this information as an educational service only. Disclaimer

13 Swidan Neuro-Endocrine-Immune

What’s The Thyroid’s Role In The Body?

 

Have you been experiencing fatigue out of nowhere? What about having constipation issues in your lower abdominals? Or have you been experiencing frequent and heavy menstrual cycles? Some of these symptoms are associated with hypothyroidism. The thyroid is located at the neck’s base and produces hormones. Studies reveal that this small organ is mighty as it has a massive responsibility to the body by controlling its metabolism, growth, and functionality. As the thyroid secretes hormones for the body, these hormones travel with the bloodstream to different organs, muscles, and tissues throughout the body. Thyroxine(T4) and triiodothyronine (T3) are the two main hormones the thyroid gland produces. While the hypothalamus produces TRH (thyrotropin-releasing hormone), and the anterior pituitary glands produce TSH (thyroid-stimulating hormone). All three of these organs work in synchronized harmony with the body by maintaining the proper mechanism and homeostasis. The thyroid hormone affects not only the body but the vital organs like:

  • Heart
  • Central nervous system
  • Autonomic nervous system
  • Lungs
  • Skeletal muscles
  • Metabolism
  • GI tract

 

The Effects Of Hypothyroidism In The Body

Since the thyroid helps regulate hormones in the body, environmental factors play a role in hormone production. When environmental factors begin to affect the body, they potentially involve hormones. When the thyroid gland cannot produce sufficient hormones in the body, it risks developing hypothyroidism. Hypothyroidism is defined as a common condition that is the result of low hormone production overlapping various conditions and manifestations. When left untreated, hypothyroidism could associate with sympathetic and parasympathetic dysfunction. Studies reveal that the thyroid hormone influences the autonomic nervous system. Individuals suffering from hypothyroidism correlate to a dysfunctional autonomic system overlapping sympathetic reactivity. This means that hypothyroidism will cause the body’s metabolism to slow down and cause various symptoms to affect each vital organ. 


An Overview Of Hypothyroidism-Video

Have you been experiencing chronic fatigue? How about muscle weakness in your arms or legs? What about feeling cold all the time? Individuals experiencing these symptoms are dealing with a condition known as hypothyroidism. The video above explains hypothyroidism, how it is diagnosed, and its symptoms in the body. Many environmental factors do play a role when it comes to the development of hypothyroidism. Some of the symptoms associated with hypothyroidism include:

  • Constipation
  • Decrease in sexual function
  • Depression
  • High cholesterol
  • Weight gain
  • Chronic fatigue
  • Brain fog
  • Hashimoto’s

When the body is being affected by environmental factors correlating with hypothyroidism, studies reveal that factors like spinal cord injuries do cause an impact on the body’s metabolic function and derange various hormonal axes. This causes issues that could potentially involve co-morbidities like urinary tract infections. Fortunately, there are ways to manage hypothyroidism and regulate the hormones to make the body functional again.


Managing Hypothyroidism

 

One cornerstone in managing hypothyroidism and reducing its associated symptoms is following a proper treatment for health and wellness. Maintaining healthy hormone levels in the body is achievable regarding hypothyroidism. Taking thyroid medication as prescribed by a doctor help improve symptoms associated with hypothyroidism while regulating T3 and T4 hormones. Eating nutritious foods may help relieve some symptoms of hypothyroidism. Exercising helps enhance energy levels and strengthen weak muscles for individuals with hypothyroidism. Incorporating chiropractic care can help reduce somato-visceral disorders associated with hypothyroidism through spinal manipulation. Utilizing these treatments to manage hypothyroidism benefits one’s health and wellness journey.

 

Conclusion

The thyroid is an organ at the neck’s base as part of the endocrine system. This organ is mighty as it helps the body by secreting hormones for all the various organs, muscles, and tissues. When the thyroid can’t produce sufficient hormones to regulate the body, it risks developing hypothyroidism. Hypothyroidism is a common condition that results in a low hormonal count, triggering symptoms that affect the body. If left untreated, it could become the mediator for sympathetic and parasympathetic dysfunction. Luckily, treatments are available to manage hypothyroidism and regulate hormonal secretion in the body. This allows the individual to incorporate healthy habits to maintain their hormones while their health and wellness journey continues impacting their lives.

 

References

Cheville, A L, and S C Kirshblum. “Thyroid Hormone Changes in Chronic Spinal Cord Injury.” The Journal of Spinal Cord Medicine, U.S. National Library of Medicine, Oct. 1995, pubmed.ncbi.nlm.nih.gov/8591067/.

Hardy, Katie, and Henry Pollard. “The Organisation of the Stress Response, and Its Relevance to Chiropractors: A Commentary.” Chiropractic & Osteopathy, BioMed Central, 18 Oct. 2006, www.ncbi.nlm.nih.gov/pmc/articles/PMC1629015/.

Mahajan, Aarti S, et al. “Evaluation of Autonomic Functions in Subclinical Hypothyroid and Hypothyroid Patients.” Indian Journal of Endocrinology and Metabolism, Medknow Publications & Media Pvt Ltd, May 2013, www.ncbi.nlm.nih.gov/pmc/articles/PMC3712377/.

Patil, Nikita, et al. “Hypothyroidism.” In: StatPearls [Internet]. Treasure Island (FL), StatPearls Publishing, 19 June 2022, www.ncbi.nlm.nih.gov/books/NBK519536/.

Shahid, Muhammad A, et al. “Physiology, Thyroid Hormone – StatPearls – NCBI Bookshelf.” In: StatPearls [Internet]. Treasure Island (FL), StatPearls Publishing, 8 May 2022, www.ncbi.nlm.nih.gov/books/NBK500006/.

Disclaimer

An Early Indication On Hyperinsulinemia

An Early Indication On Hyperinsulinemia

Do you feel:

  • Agitated, easily upset, nervous?
  • Like you crave sweets during the day?
  • That eating sweets does not relieve cravings for sugar?
  • That you must have sweets after meals?
  • Hormone imbalances?

If you are experiencing any of these situations, then your blood glucose levels are dramatically fluctuating up and down. It might be an early indication of hyperinsulinemia in your body.

When it comes to the body, many people often try to make sure that their body is healthy and strong by eating the right food, exercising regularly, and even getting a routine check-up from their primary healthcare providers. Even though people can achieve this, sometimes harmful pathogens like autoimmune diseases, metabolic syndrome, and chronic illnesses can affect the body. When harmful pathogens attack the body from the inside, it can cause the body to dysfunction, especially the body’s system. Many people have found ways to dampen the effects that harmful pathogens have caused in their bodies. However, there are some people who are autoimmune compromises or even have diabetes have taken the necessary precautions to make sure that they are in control of their bodies.

It is surprising that when people are controlling their insulin levels, they are accustomed to think that insulin is a blood sugar-regulating hormone. Research shows that when the blood glucose rises in the body, insulin is being secreted in the body to help bring the blood glucose down a bit. This is a partial stimulation known as insulin-sensitive glucose transporters, and this is one of the many roles that insulin provides that are unrelated to the body’s blood glucose. When the blood glucose levels are rising and falling dramatically in the body, it can cause anyone who has diabetes to go into DKA or diabetic ketoacidosis.

Chronic Hyperinsulinemia

Studies have found that when diabetic individuals are keeping an eye on their blood glucose levels, they go on a ketogenic diet to keep their ketones under control. It is a surprise to many people that insulin is not required for cellular glucose uptake. The research study mentioned that when individuals are in a deficient carbohydrate diet, their bodies can regulate and control the production of the ketone bodies, causing a harmless physiological state known as dietary ketosis. The study even mentioned that when ketone bodies are flowing from the liver to the brain, it can be used as fuel. When this happens, spare glucose metabolism is very similar to the mechanism of spare glucose that is oxidizing fatty acids as an alternative fuel.

Picture-of-woman-doing-injection-with-insulin-pen_MEDIUM

There is another study that shows that the use of exogenous insulin in individuals who have type 1 diabetes may need to suppress the free glucagon secretion that facilitates glucose transport into their cells. The hormone glucagon has a stimulatory effect on fuel production from the liver and can even modulate the hepatic glucose uptake and the hepatic glycogen synthesis in the body. The study even shows that the hormone glucagon has been longed dismissed as a minor contributor to metabolic diseases in the body. Not only that, but glucagon can even increase hepatic glucose from the liver to the brain and ketone production in the body.

Research on Hyperinsulinemia

What is interesting is that when insulin�s myopic focus is related to blood glucose. Research shows that many people have missed a host of health problems that can occur in the presence of average glucose in the body, but it is known as chronically elevated insulin. The research study showed that when there is a lack of insulin in the liver, it causes glycogenolysis and gluconeogenesis are being activated. When this happens, it can further enhance an overproduction of hormones like glucagon and cortisol, which can stimulate the process of insulin deficiency. A study has found that when a person has chronically elevated insulin or hyperinsulinemia, it can develop cardiometabolic diseases even if elevated glucose is absent. This is due to fasting glucose being part of a routine check-up and chronically elevated glucose.

Studies have shown that chronic hyperinsulinemia is the main factor in POS (polycystic ovarian syndrome) and that there is a high prevalence of undiagnosed insulin resistance with patients who have Parkinson’s disease. Chronic hyperinsulinemia can contribute to insulin resistance, as studies show that this factor can alter lipid metabolism in the body. The research study even shows that insulin sensitivity can be determined by hyper-insulinemic and can lead to weight gain, raised plasma triglycerides, and free fatty acids in the body.

Chronic hyperinsulinemia can be present long before there is a rise in blood glucose. Research shows that there are at least five stages in the progression of diabetes, and it can indicate any metabolic dysfunction that is happening in the body. In one study, it showed that there is an association between hyperinsulinemia in the fasting state and the development of diabetes. The study mentioned that basal hyperinsulinemia in adults who are normoglycemic could constitute an independent risk factor for metabolic deterioration to dysglycemia and can even help identify healthy subjects that may have an increased risk for diabetes.

Conclusion

All in all, if someone wants to make sure that their insulin levels are functioning correctly, they will have to be in a very low-carbohydrate ketogenic diet and keep an eye on their blood glucose levels. Individuals that are living with a condition due to chronic hyperinsulinemia, there are effective ways to manage this condition and even preventing it. Many people should start eating healthy, nutritional food, exercise regularly, and start developing healthy habits in order to achieve an overall sense of health and wellness. Some products are beneficial to regulate blood glucose by providing support to sugar metabolism with hypoallergenic nutrients, enzymatic cofactors, metabolic precursors, and phytonutrients.

The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.


References:

Dankner, R, et al. �Basal State Hyperinsulinemia in Healthy Normoglycemic Adults Heralds Dysglycemia After More Than Two Decades of Follow Up.� Diabetes/Metabolism Research and Reviews, U.S. National Library of Medicine, July 2012, pubmed.ncbi.nlm.nih.gov/22865584/.

Hogg, Elliot, et al. �High Prevalence of Undiagnosed Insulin Resistance in Non-Diabetic Subjects With Parkinson’s Disease.� Journal of Parkinson’s Disease, U.S. National Library of Medicine, Feb. 2018, pubmed.ncbi.nlm.nih.gov/29614702/.

Manninen, Anssi H. �Metabolic Effects of the Very-Low-Carbohydrate Diets: Misunderstood �Villains� of Human Metabolism.� Journal of the International Society of Sports Nutrition, BioMed Central, 31 Dec. 2004, www.ncbi.nlm.nih.gov/pmc/articles/PMC2129159/.

Morita, Ippei, et al. �Chronic Hyperinsulinemia Contributes to Insulin Resistance under Dietary Restriction in Association with Altered Lipid Metabolism in Zucker Diabetic Fatty Rats.� American Journal of Physiology. Endocrinology and Metabolism, U.S. National Library of Medicine, 1 Apr. 2017, www.ncbi.nlm.nih.gov/pubmed/28143857.

Sonksen, P., and J. Sonksen. �Insulin: Understanding Its Action in Health and Disease.� British Journal of Anaesthesia, 1 July 2000, bjanaesthesia.org/article/S0007-0912(17)37337-3/fulltext.

Team, DFH. �Hyperinsulinemia: An Early Indicator of Metabolic Dysfunction.� Designs for Health, 12 Mar. 2020, blog.designsforhealth.com/node/1212.

Unger, Roger H, and Alan D Cherrington. �Glucagonocentric Restructuring of Diabetes: a Pathophysiologic and Therapeutic Makeover.� The Journal of Clinical Investigation, American Society for Clinical Investigation, Jan. 2012, www.ncbi.nlm.nih.gov/pmc/articles/PMC3248306/.

Weir, Gordon C, and Susan Bonner-Weir. �Five Stages of Evolving Beta-Cell Dysfunction During Progression to Diabetes.� Diabetes, U.S. National Library of Medicine, Mar. 2004, pubmed.ncbi.nlm.nih.gov/15561905/.


Modern Integrative Wellness- Esse Quam Videri

The University offers a wide variety of medical professions for functional and integrative medicine. Their goal is to inform individuals who want to make a difference in the functional medical fields with knowledgeable information that they can provide.

Balance Hormones Naturally

Balance Hormones Naturally

Keeping hormones in balance can be a tough challenge. There are many individuals with hormonal imbalances and they don’t even know it. Despite�tests for abnormal thyroid function, they don’t always acknowledge a thyroid that isn�t functioning properly. The same can be said for the adrenals. When they are overtaxed, the imbalance that follows can be quite challenging. There are top-quality natural remedies for hormonal imbalance.

 

11860 Vista Del Sol, Ste. 128 Balance Hormones Naturally El Paso, Texas

How to tell

Under-producing glands will have some symptoms that are different from glands that are over-producing. But there are some symptoms that are shared across the board.

If you notice that you experience several of these symptoms, it could point to a hormonal imbalance:

  • Aches and pain in the muscles
  • Anxiety
  • Confusion and lack of mental clarity
  • Depression
  • Fatigue
  • Memory loss
  • Migraines
  • Muscle weakness
  • Sexual dysfunction
  • Swelling
  • Weight loss or gain without doing anything new/different

A chiropractor, naturopath, or specialist can help you determine if you have a hormonal imbalance. Medical doctors often prescribe medications, but in most cases, the imbalance can be corrected with a natural treatment. These treatments are highly beneficial in treating hormonal imbalances. They can be done separately or combined.

 

Herbs & Oils

There are several herbs and essential oils that work wonders when it comes to balancing hormones. Ashwagandha is at the top of the list for treating overactive or sluggish thyroid as well as overtaxed adrenals. It’s available as a tablet, capsule, in powder form, or as a liquid. Mixing � to � teaspoons of powder into some milk with honey and drinking it just before bed can help sleep, calm stress and balance the hormones. Various oils like clary sage, lavender, and sandalwood help reduce stress and promote wellbeing. Hormonal balance comes as a natural result. Put 3 to 5 drops in a diffuser and breathe in.

 

11860 Vista Del Sol, Ste. 128 Food Sensitivities and Gut Health El Paso, TX.

Nutritional Balance

Hormonal imbalance can often be the result of stress, whether emotional stress from everyday life or physical stress from poor habits like not getting the proper amount of sleep and not maintaining a proper diet. Omega 3 and 6 fatty acids are vital for heart health, vibrant skin and hormonal balance.

Other nutrients include vitamin D, B complex, and magnesium. If not getting enough in the foods you eat, then consider supplements. Give the body a great boost by taking probiotics and reaping the healing properties of bone broth. Bone broth is available in powder or liquid or you can make your own. There is intense nutrition in broth so incorporating it into your diet is a very wise decision.

Natural Balance

Chiropractic is a powerful treatment for hormonal imbalance. It focuses on the heart of factors that cause the body to go out of balance and treats the problem at the root. It can relieve stress in the body and reduce and eliminate pain, which can contribute to hormonal imbalances. It is considered one of the best natural treatments for hormonal imbalance because it brings the body back into balance.

The whole-body approach that chiropractic offers means that you get recommendations on:

  • Healthy diet
  • Exercise
  • Lifestyle changes

All of these work together to balance your body and balance hormones for a healthier, happier you.


 

Back Pain Treatment


 

NCBI Resources

 

Metabolic Syndrome: Home Solutions

Metabolic Syndrome: Home Solutions

Metabolic Syndrome affects many people. In fact, more than a quarter of the United States has it! Metabolic Syndrome is not a disease, but instead a cluster of disorders. These disorders on their own are not necessarily alarming but when you have more than one, the body starts to feel the repercussions.

Symptoms

Those with metabolic syndrome often suffer from frequent headaches, inflammation, nausea, fatigue, joint pain, and many more. On top of these symptoms, metabolic syndrome can put individuals at a higher risk for Type 2 Diabetes, Heart Disease, Stroke, Obesity, Sleep Apnea, and Kidney Disease.

Risk Factors

Individuals who have an “apple or pear” body shape, are at an increased risk for developing metabolic syndrome. There are no “obvious” signs of metabolic syndrome, but rather one with metabolic syndrome has 3/5 of these risk factors.

  • A fasting blood glucose level of 100 mg/DL
  • High Blood Pressure, measuring 130/85
  • High Triglycerides
  • Low HDL (Good Cholesterol)� measuring <40mg/DL Men & <50mg/DL Women
  • Excess Waist Fat (>40in Men & >35in Women)

What Can You Do About It?

Of course, no one wants to be left feeling sick and stranded. There are ways to help prevent metabolic syndrome at home. Below there are five tips for each risk factor and how to prevent/reduce your symptoms.

A Fasting Blood Glucose Level Of 100 mg/DL

  • Ketogenic Diet
  • Increase Fiber
  • Control Portions
  • Set “Carb Goals”
  • Choose complex carbs over simple carbs

High Blood Pressure, measuring 130/85

  • Reduce Sodium
  • Lower caffeine
  • DASH diet (Dietary Approaches to Stop Hypertension)
  • Boost Potassium
  • Read Food labels

High Triglycerides

  • Limit sugar intake
  • Increase fiber
  • Establish a regular eating pattern
  • Eat more “tree nuts” ( almonds, cashews, pecans)
  • Switch to unsaturated fats

Low HDL ( Good Cholesterol) measuring <40mg/DL Men & <50mg/DL Women

  • Reduce Alcohol
  • Do not smoke
  • Choose better fats
  • Purple Produce (antioxidants to help inflammation)
  • Increase fish consumption

Excess Waist Fat >40 in Men & >35 in Women

  • Ketogenic Diet
  • Exercise Daily
  • Walk after dinner
  • Grocery Shop without Aisles
  • Increase in Water Consumption

Solutions

Aside from doing these tricks and tips at home, a doctor or health coach will be able to further assist one in healing. The main goal is to take these symptoms and disorders and correct them before they become a full-blown diagnosis.

Rather than just running a basic blood panel, they now have tests that allow us to see multiple different levels and numbers. these elaborate blood tests provide great insight to allow us to see the full picture. By completing these labs, it allows the doctor to evaluate the patients better and provide a more specific treatment plan.

In addition to detailed lab work, there are all-natural supplements that have been shown to help improve these symptoms along with proper diet and exercise. Some of these supplements include Vitamin D, Berberine, and Ashwagandha.

On top of these things, there is also an app that is available to download. This app is called, “Dr. J Today”. This app connects you directly to our clinic and allows us to monitor your diet, supplements, activity, BMI, water weight, muscle mass, and more! This app also gives you a direct portal to message Dr.Jimenez or myself.

As stated before, our main goal is to help you decrease your symptoms before they turn into a full-blown diagnosis. One thing we want to surround our patients with is knowledge and a team atmosphere. With the right team, anything is possible and better health is more attainable than you think!

Having Type 1 Diabetes, I have experienced metabolic syndrome before. It is one of my least favorite feelings that exist. I want our patients to know that they do not have to feel that way and there are treatment plans that can help! I will help to create a personalized plan that is tailed to you, so success is the only option. – Kenna Vaughn, Senior Health Coach�

The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.

References:
Mayo Clinic Staff. �Metabolic Syndrome.� Mayo Clinic, Mayo Foundation for Medical Education and Research, 14 Mar. 2019, www.mayoclinic.org/diseases-conditions/metabolic-syndrome/symptoms-causes/syc-20351916.
Sherling, Dawn Harris, et al. �Metabolic Syndrome.� Journal of Cardiovascular Pharmacology and Therapeutics, vol. 22, no. 4, 2017, pp. 365�367., doi:10.1177/1074248416686187.

Functional Endocrinology: Menopause and Osteoporosis

Functional Endocrinology: Menopause and Osteoporosis

Do you feel:

  • Perimenopausal?
  • Inflammation in the joints?
  • Alternating menstrual cycle lengths?
  • Hot flashes?
  • Hormonal imbalances?

If you are experiencing any of these situations, then you might be experiencing menopause and its symptoms.

When a woman hits their late forties and entering their early fifties, they go through the natural aging process known as menopause. Menopause is when a woman has not menstruated in about twelve consecutive months as well as can no longer become pregnant. With menopause comes uncomfortable symptoms like hot flashes, vaginal dryness, and hormones imbalance. For women, hormone imbalances can range from having too much or too little hormones in the body’s bloodstream. When menopause occurs, the loss of the ovarian function in a female’s body can have an impact on their skeletal health, causing osteoporosis in the joints.

Osteoporosis and Menopause

Surprisingly though, the hormone estrogen can play a role in the development of osteoarthritis and when a woman is under the menopausal phase. They can experience a decline in their estrogen levels, and osteoporosis will begin to wreak the bones and joints, causing chronic inflammation. Studies have found out that when estrogen hormones begin to change during healthy menopausal changes, they will begin to fluctuate then suddenly drop. They stated that estrogen helps prevent bones from getting weaker through the natural breakdown. Any fractures from accidents can cause pain, decreased mobility, and normal function of the female body due to osteoporosis.

osteoporosis-cropped

There is even more evidence that the fluctuation of estradiol that may even be more pronounced in the perimenopause and might not be able to correlate well with bone density and loss for the body. So, during the menopausal stage, the bone density will deteriorate when females have osteoporosis. There have been rumors that osteoporosis is something that a person should not have to worry because it only happens if there is a family history of osteoporosis. Sadly though, osteoporosis is a common bone disease, and having a family history of the disease can increase the chances. However, there are also other risk factors that can cause osteoporosis like:

  • Excessive alcohol
  • Amenorrhea
  • Smoking
  • Low body weight

Research shows that osteoporosis does start when a woman is at the start of the menopausal stage and has stopped ovulating, her monthly menstrual cycle stops. Her estrogen levels will dramatically stop, as well. It stated that women could have a total bone loss within the first ten years that follow menopause. When there is a lack of estrogen in the body due to menopause, bone density loss is much more significant and can cause fractures in the body. Studies have found out that local health care professionals will ask women about the amount of bone density that has been lost during their menopausal transition and when they begin. They even found out that the follicle-stimulating hormone in women has changed as well during their menopausal transition.

Bone Remodeling

Furthermore, studies found that over 20 American individuals are affected by osteoporosis, and this can lead to about 1.5 million bone fractures each year, thus making osteoporosis to be one of the leading public health problems. More studies even found that women would lose at least fifty percent of their trabecular bone, and about thirty percent of their cortical bone in their body will eventually be lost during the first ten years during their postmenopausal stage. Women must at least take vitamin D supplements to make sure that their bones are healthy and are not prone to bone loss or fractures.

There is information about why bone loss seems to accelerate after a woman�s menstrual cycle has ended and why bone remodeling can help replace the old bones that have been lost due to osteoporosis or due to fracture. Surprisingly though, bone remodeling is a process to replace old bones with new bones for the body, and it is consists of five phases. They are:

  • Activation: During this phase of bone remodeling, osteoclasts are being recruited to the surface of the bone.
  • Resorption: In this phase, the osteoclast is being generated into an acidic microenvironment on the surface of the bone, thus dissolving and resorbing the bone�s mineral content.
  • Reversal: In this phase, the osteoclast then undergoes apoptosis and then is being recruited onto the bone�s surface.
  • Formation: This is the last phase of bone remodeling as the osteoclast deposits collagen and then being mineralized to form a new bone in the body.

Conclusion

Menopause is a natural part of hormone levels to drop, and women cannot get pregnant any more. One of the most common signs that menopausal women encountered is osteoporosis. Osteoporosis is when bones become brittle and can break from falls or injury. Women need to take supplements for bone health so that way the bones and the body is functioning correctly. Some products are designed to help support the estrogen metabolism in both the female and male bodies as well as products to help support the hormonal balance and the normal menstruation for females in the reproductive age.

The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.


References:

Duggal, Neel. �What�s the Connection Between Menopause and Arthritis?� Healthline, 11 May, 2017, www.healthline.com/health/menopause/menopausal-arthritis.

Finkelstein, Joel S, et al. �Bone Mineral Density Changes during the Menopause Transition in a Multiethnic Cohort of Women.� The Journal of Clinical Endocrinology and Metabolism, The Endocrine Society, Mar. 2008, www.ncbi.nlm.nih.gov/pmc/articles/PMC2266953/.

Rodriguez, Diana, et al. �The Osteoporosis-Menopause Connection.� EverydayHealth.com, 16 Feb. 2016, www.everydayhealth.com/menopause/osteoporosis-and-menopause.aspx.

Rosen, Clifford, and Ramon Martinez. �Post Menopause and Osteoporosis.� Hormone Health Network, Mar. 2019, www.hormone.org/diseases-and-conditions/menopause/post-menopause-and-osteoporosis.

Sowers, MaryFran R, et al. �Amount of Bone Loss in Relation to Time around the Final Menstrual Period and Follicle-Stimulating Hormone Staging of the Transmenopause.� The Journal of Clinical Endocrinology and Metabolism, The Endocrine Society, May 2010, www.ncbi.nlm.nih.gov/pmc/articles/PMC2869543/.

Team, Penn Medicine. �Menopause And Osteoporosis: What’s The Connection? � Penn Medicine.� � Penn Medicine, 18 Mar. 2016, www.pennmedicine.org/updates/blogs/womens-health/2016/march/menopause-and-osteoporosis.

Tella, Sri Harsha, and J Christopher Gallagher. �Prevention and Treatment of Postmenopausal Osteoporosis.� The Journal of Steroid Biochemistry and Molecular Biology, U.S. National Library of Medicine, July 2014, www.ncbi.nlm.nih.gov/pmc/articles/PMC4187361/.


Modern Integrative Wellness- Esse Quam Videri

The University offers a wide variety of medical professions for functional and integrative medicine. Their goal is to inform individuals who want to make a difference in the functional medical fields with knowledgeable information that they can provide.

 

 

Functional Endocrinology: Perimenopause

Functional Endocrinology: Perimenopause

Do you feel:

  • Hot flashes?
  • Mental fogginess?
  • Disinterest in sex?
  • Mood swings?
  • Increased vaginal pain, dryness, or itching?

If you are experiencing any of these situations, then you might be going through perimenopause.

When the body hits a certain age, the hormone levels will naturally increase then decrease, causing the person to experience symptoms that they never have. For women, they go through an aging progression known as menopause, which is a normal part of aging, and when the female stops producing eggs. Menopause occurs when a female is in her late forties to her early fifties, depending on which country they are from. Before a woman goes through the menopausal process, perimenopausal begins before the actual menopausal progression occurs. Not only that but when a woman goes through perimenopause, their endocrine system is being affected with hormonal changes as the hormones begin to fluctuate during the menopausal shift.

Perimenopausal

Perimenopausal can be defined in various ways; however, researchers can agree that perimenopausal begins when a woman starts to have irregular menstrual cycles. This is due to a natural decline in their ovarian function, and it will be their last menstrual period. Research shows that perimenopausal leads up to menopause and follows after post-menopause. Surprisingly though, during perimenopausal years, the hormone levels will begin to fluctuate, and the estrogen levels begin to become a bit higher than average. Afterward, though once menopause goes through the postmenopausal stage, the hormone levels will begin to decrease gradually naturally.

Perimenopausal Symptoms

estrogen

When it comes to the endocrine system, it plays a role when a female is going through perimenopause. Since the endocrine system produces hormones and is responsible for reproduction hormones, it makes sure that the female body has the two hormones estrogen and progesterone. When there is a lack of hormones in the female body, it is due to the effects of hot flashes that are caused by perimenopause. Now research shows that most women do not expect that to have hot flashes until they have menopause. It is one of the symptoms that all females get. Other symptoms can cause women to have them when they are going through. They are:

  • Hot flashes and night sweats: There is about an estimated 35%-50% of women who have perimenopausal, will suffer a sudden wave of body heat that is consist of sweating ant flushing that can last about five to ten minutes. Surprisingly it can happen at night as well when the body starts to sweat.
  • Vaginal dryness: When estrogen levels began to decline during late perimenopause naturally, it can cause the vaginal tissue to become a bit thinner and drier. When this happens, it can cause irritation, itching, and can be a source of pain during intercourse.
  • Uterine bleeding: When the progesterone levels start to decline, it can cause the growth of the endometrium, which is the uterine lining to become a bit thinker than usual before it sheds, thus resulting in a very heavy period. Not only that, but if a female has fibroids or endometriosis, then those two conditions may become a bit more troublesome.
  • Sleep problems: Studies found out that about forty percent of perimenopausal women have trouble sleeping. Between the night sweats and the disrupted sleep patterns, the problem can be a little complex to be blamed on the hormone oscillation, and the sleep cycles change as a person ages. Plus, insomnia is a common complaint for both sexes.
  • Mood swings: There is about ten to twenty percent of women who have experienced mood swings during perimenopause that has been linked to low estrogen levels. When women have experienced mood swings, it usually happens around midlife, like stress, poor overall health, and a history of depression.
  • Short term memory: Surprisingly, many women have complained about having short term memory problems as well as having a difficult time concentrating during the menopausal transition. Even though estrogen and progesterone help maintain brain function, there is too little information to separate the effects of aging and the psychosocial factors that can be related to hormone changes.

Studies have even found out that during the menopausal transition, the regular patterns of a female’s menstrual cycle will become disrupted, and the normal ovulatory cycle will decline naturally. At the same time, the gonadotropin levels will start to rise as well as the follicle-stimulating hormones will increase on a woman’s feature.

Conclusion

Menopause is a natural stage in a woman’s life. The hormone levels will begin to fluctuate, and it all starts when a woman’s menstrual cycle begins to stop. With perimenopause, it is the beginning of the menopausal transition as the female body starts to change. From hot flashes to irregular sleep patterns, perimenopause is a natural way to let the body know that change is coming. Some products are designed to help support the estrogen metabolism in both the female and male bodies as well as products to help support the hormonal balance and the normal menstruation for females in the reproductive age.

The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.


References:

Publishing, Harvard Health. �Perimenopause: Rocky Road to Menopause.� Harvard Health, June 2009, www.health.harvard.edu/womens-health/perimenopause-rocky-road-to-menopause.

Buckler, Helen. �The Menopause Transition: Endocrine Changes and Clinical Symptoms.� The Journal of the British Menopause Society, U.S. National Library of Medicine, June 2005, www.ncbi.nlm.nih.gov/pubmed/15970017.

Cherney, Kristeen. � Effects of Menopause on the Body.� Healthline, 5 Feb. 2019, www.healthline.com/health/menopause/hrt-effects-on-body.

Edwards, Beatrice J, and Jin Li. �Endocrinology of Menopause.� Periodontology 2000, U.S. National Library of Medicine, Feb. 2013, www.ncbi.nlm.nih.gov/pubmed/23240949.

Wexler, Tamara L. �Perimenopause and Menopause Overview.� EndocrineWeb, 25 Mar. 2016, www.endocrineweb.com/conditions/menopause/perimenopause-menopause-overview.


Modern Integrative Wellness- Esse Quam Videri

The University offers a wide variety of medical professions for functional and integrative medicine. Their goal is to inform individuals who want to make a difference in the functional medical fields with knowledgeable information that they can provide.

Functional Endocrinology: Blood-Brain Barrier and The Endocrine System

Functional Endocrinology: Blood-Brain Barrier and The Endocrine System

Do you feel:

  • Hormone imbalances?
  • Craving sweets during the day?
  • Weight gain?
  • Overall sense of bloating?
  • Shaky, jittery, or have tremors throughout your body?

If you are experiencing any of these situations, then it might be your blood-brain barrier and your endocrine system that may be imbalanced.

The brain in the human body is the primary control system that makes sure that each of the body’s system is working correctly. This includes the gastrointestinal system, the hepatic system, the neurological system, and, most importantly, the endocrine system. In the brain, however, there is a tissue known as the blood-brain barrier, it is connected to the endocrine system. It is essential to make sure that the blood-brain barrier and the endocrine system are healthy in the human body.

The Blood-Brain Barrier

The blood-brain barrier in the body separates the central nervous system from peripheral tissue. Even though the blood-brain barrier separates the nervous system, it does not prevent hormones from entering the brain. Research shows that the brain can bind and secretes any circulating substances and can be qualified as an endocrine organ. When this happens, it can be one of the largest and most metabolically active of the endocrine organs by acting as both the target and secretor of hormones.

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With the blood-brain barrier, it conveys the blood vessels by transporting the blood from the heart to every tissue and organs throughout the body. It then delivers oxygen and the nutrients to all the tissues and removing the carbon dioxide and metabolic waste from the tissues. The blood vessels also convey hormonal signals to the tissues and is a mediator for interacting with the peripheral immune system with each tissue. Research shows that since the blood-brain barrier is an endocrine tissue, the substances that are being carried in the blood can emerge in a hormone-like fashion. The research stated that the blood-brain barrier could exhibit the endocrine system properties as well as being a target for hormones that can affect many of the blood-brain functions in the body.

The Endocrine System

The endocrine system is a collection of glands that secretes out and produces hormones that can regulate not only the body but makes sure that it regulates the body’s metabolism and many other functions that the body needs to function correctly. When the body’s hormone levels fluctuate, it can be very good or horrible, depending on the situation. If the body produces an abundance of hormones, it can cause a person to have hyperthyroidism, and when the body produces a low abundance of hormones, the body can have complications and cause the body to develop chronic illnesses. Stress, infections, and diabetes can influence the body’s hormone levels by making hormones either too much or too little. By making sure that the body’s hormones are at a balanced level is essential because eating right and doing daily exercises can make the body function properly and feel good as well.

Since the body can produce hormones naturally, the job of the primary hormone is to make sure that it is traveling in the bloodstream and making it to the various organs and tissues that need the hormone levels. The hormone levels can tell every organ and tissues what to do and how to function. When the hormone levels get crazy by being produced too much or too little, it causes those organs and tissues to malfunction.

For the blood-brain barrier, since it is an endocrine tissue, it can divide the hormone receptors. The research found out that the blood-brain barrier can respond to circulate the hormone substances and secrete those hormone substances into the blood circulation and the central nervous system. It can also make sure that when the hormone receptors are being divided that it goes to the central nervous tissues and the peripheral tissues. The research also found out that insulin levels can also affect the brain’s endothelial cell function through several parameters and modulating amino acids, leptin, and p-glycoprotein transporters in the body.

Surprisingly there is a unique feature that the blood-brain barrier possesses. The blood-brain relies on its cell membrane surfaces facing into the bloodstream and the interstitial fluid of the central nervous system so that way it can receive signals for the body. The research found out that the blood-brain barrier’s properties are primarily manifested within the brain’s endothelial cells. They can be induced and maintained through critical interactions with the cells that are interacting in the neurovascular unit in the brain. With these endocrine-like mechanisms that the blood-brain barrier has, it can help dampen the effects of endocrine diseases like neurodegenerative conditions and Alzheimer’s disease.

Conclusion

The blood-brain barrier is an essential tissue in the brain as it functions as an endocrine tissue and does play a role by interacting with the hormone levels that the endocrine system secreted out to the body. When the hormone levels start to malfunction by either producing an abundance or too little amount of hormones, it can cause the body to have chronic illnesses and the blood-brain barrier to dysfunction in the brain, causing degenerative neurological disorders in the brain as well. Some products can help the endocrine system by making sure the hormone levels are balanced as well as products for a healthy brain function for a healthy body.

The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.


References:

Banks, William A. �Brain Meets Body: the Blood-Brain Barrier as an Endocrine Interface.� Endocrinology, Endocrine Society, Sept. 2012, www.ncbi.nlm.nih.gov/pmc/articles/PMC3423627/.

Banks, William A. �The Blood-Brain Barrier as an Endocrine Tissue.� Nature Reviews. Endocrinology, U.S. National Library of Medicine, Aug. 2019, www.ncbi.nlm.nih.gov/pubmed/31127254.

Daneman, Richard, and Alexandre Prat. �The Blood-Brain Barrier.� Cold Spring Harbor Perspectives in Biology, Cold Spring Harbor Laboratory Press, 5 Jan. 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC4292164/.

Zimmermann, Kim Ann. �Endocrine System: Facts, Functions and Diseases.� LiveScience, Purch, 18 Feb. 2018, www.livescience.com/26496-endocrine-system.html.


Modern Integrative Wellness- Esse Quam Videri

The University offers a wide variety of medical professions for functional and integrative medicine. Their goal is to inform individuals who want to make a difference in the functional medical fields with knowledgeable information that they can provide.

 

 

 

Functional Endocrinology: Andropause

Functional Endocrinology: Andropause

Do you feel:

  • A decreased libido?
  • Difficulty urinating or dribbling
  • Spells of mental fatigue?
  • Decreased fullness of erection?
  • Inability to concentrate?

If you are feeling or experiencing any of these situations, then you might be experiencing male menopause or andropause.

When men and women are heading to their 50s, their bodies start to change. For women, they start to develop hot flashes, and their hormones start to change as well. Since it is normal for hormones to change naturally when a person is aging, it affects women more than men. Studies have shown that sex hormones in males occur gradually as they age. There is a term called “male menopause,” and it is defined when males have a decreased level of testosterone that is related to aging. Many healthcare professionals have another name for “male menopause,” and that is andropause.

Andropause

Andropause and menopause are entirely different since menopause causes a woman’s ovulation and hormones to plummet for a short period. With andropause, it causes a male’s testosterone production and their other hormones to decline for many years. Since testosterone levels in males are vastly different, older men tend to have lower levels than younger men, and testosterone levels can gradually decline throughout adult life.

andropause.jpg

Studies found that when a person ages, their aging process can affect the body�s systems, including the endocrine system. When a person is aging, their adrenal glands will go through morphological changes, and those changes can alter their cortex endocrine functions. Another study showed that since andropause is age-related, there is a partial insufficiency in the adrenal cortex in the endocrine system, and there are low levels of DHEA (dehydroepiandrosterone) and DHEA sulfate that can affect the cortisol levels.

DHEA and DHEA Sulfate

With DHEA and DHEA sulfate, research has found that these two are steroids that are produced abundantly by the adrenal glands in the endocrine system.� With these two components, they provide beneficial properties and effects that have anti-aging properties to stimulate the immune system and the endocrine system. When males are going through the changes as they get older, their hormones will naturally decrease in their bodies.

Since andropause is age-related and has partial insufficiency on the adrenal cortex and it is characterized by low blood levels of DHEA and DHEA sulfate when it is under the presence of cortisol levels in the body. With andropause and its characteristics, it shows how males have low DHEA levels, and it can cause them to have a higher risk of erectile dysfunction in their bodies. It is essential to know that the endocrine system initiates the aging process.

Andropause Factors

Some studies show how there are changes in the endocrine pathways and are being accompanied by healthy aging. The changes can be from growth hormones to sex hormones in the male�s bodies. The results show a clinical significance of these changes and have the results morphologically and functionally. Surprisingly there have been many age-associated diseases like epithelial skin cancer and neurodegenerative diseases that can attack the body due to the lack of hormones that are being produced. Hence hormone replacement therapies are conducted for older individuals.

When it comes to andropause and low testosterone in males, there are recognizable signs and symptoms that healthcare professionals and male individuals should look for. They can be:

  • Sexual function: Low testosterone level can reduce sexual desire, causes erectile dysfunction and infertility, to name a few. Even male’s testes might be smaller as well.
  • Sleep patterns: Sleep disturbances like insomnia or feeling more tired is due to low testosterone in the body.
  • Physical changes: For males who have low testosterone, various physical changes can happen to their bodies. They can either have increased body fat, reduced muscle bulk, and decrease bone density. Sometimes the male body can develop gynecomastia (swollen breast) and body hair loss.
  • Emotional changes: With low testosterone levels, they can make males have a decrease in motivation or self-confidence.

It is essential to know that when males have low testosterone, they can go for testosterone therapy to help dampen the signs and symptoms that they might experience.

Conclusion

Andropause is when males have low testosterone levels in their bodies. Naturally, hormone levels can decrease when males get older, and it is essential to know that there is testosterone therapy for males who have low levels of this hormone. It is ok to be on a healthy lifestyle and eating natural foods that can help boost up hormone levels in the body to make sure that it is functioning correctly. Some products are here to help the endocrine system and support the metabolic system as well. They even help the adrenal glands and support the gastrointestinal system to make sure the body is functioning correctly for a healthy new year.

The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.


References:

Makrantonaki, Evgenia, et al. �Skin and Brain Age Together: The Role of Hormones in the Ageing Process.� Experimental Gerontology, U.S. National Library of Medicine, Oct. 2010, www.ncbi.nlm.nih.gov/pubmed/20719245.

Nawata, Hajime, et al. �Adrenopause.� Hormone Research, U.S. National Library of Medicine, 2004, www.ncbi.nlm.nih.gov/pubmed/15539809.

Papierska, Lucyna. �Adrenopause – Does It Really Exist?� Przeglad Menopauzalny = Menopause Review, Termedia Publishing House, June 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5509973/.

R�mmler, Alexander. �Adrenopause and Dehydroepiandrosterone: Pharmacological Therapy versus Replacement Therapy.� Gynakologisch-Geburtshilfliche Rundschau, U.S. National Library of Medicine, Apr. 2003, www.ncbi.nlm.nih.gov/pubmed/12649580.

Staff, Mayo Clinic. �Understanding Aging and Testosterone.� Mayo Clinic, Mayo Foundation for Medical Education and Research, 18 May 2017, www.mayoclinic.org/healthy-lifestyle/mens-health/in-depth/male-menopause/art-20048056.


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By informing individuals about how the National University of Health Sciences provides knowledge for future generations who want to make a difference in the world. The University offers a wide variety of medical professions for functional and integrative medicine.

 

Functional Endocrinology: The Mind-Body Connection and Stress Part 1

Functional Endocrinology: The Mind-Body Connection and Stress Part 1

Do you feel:

  • Stressed out after a long day?
  • Irritable if meals are missed?
  • Shaky, jittery, or have tremors?
  • Agitated, easily upset, or nervous?
  • Hormone imbalance?

If you are experiencing any of these situations, then your mind-body connection might be unbalanced.

Throughout history, there have been studies and theories that the mind and body are separate. This theory has been accepted by many; however, there is so much evidence showing the mind, and the body having a bidirectional relationship in the body like the gut system that sends signals to the brain and vise versa. Since each organ sends its signals to the brain, the endocrine system sends out signals to the brain in the form of hormones, which can alter the person’s perception of the world through their eyes.

With that in mind, neuroplasticity has shown people that when they are in their environment, it can be altered the physical make up of the environment. Many modern scientists have acquired very sophisticated tools that can monitor the body’s brainwaves, the microbes, and many other factors that can change the body’s mind. Since stress is a full-body response, it can be both a good thing and a bad thing for the body. Good stress in the body gives the “fight or flight” response while the bad stress can become chronic and can lead the body to be dysfunctional. So the idea of having the mind and the body being a separate function seems to be a bit outdated but also informational.

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By exploring the science and psychology of the mind-body disconnect, researchers can see how a person�s hormones can affect their perception of the world. By diving into the body, researchers can also see how stress can produce any visible changes in the brain as well.

How Experiences Alters the Mind

Many experiences can alter the mind. Whether it be good experiences that can be used in the work atmosphere or it can be bad experiences like being traumatized from horrible events. Studies show that trauma can alter the mind and depend on the situation. Even though the damage that is caused by trauma can be healed if it is minor. In some cases, it can scar a person even though the physical damage is healed. The mental damage is affected as a person can relive the traumatic experience that they encountered.

With good experience, they can be useful to a person if the damage has minored. If a person accidentally hurt themselves from any activities, they know not to do that again. Although if a person practices on specific activities and get better at it with time, it becomes a skill they can use. Sometimes a person can have a set of specific skills that are beneficial when they are working in the job they are in. So depending on the experiences that a person is dealing with, it can be either good or bad, but their brains will remember it.

The Difference Between Dualism and Monism

There has always been a philosophical debate on the mind and body. There are different ways to look at the mind-body connection, as many researchers have debated whether the mind is part of the body or that the body is part of the mind. Thus the difference between Dualism and Monism has different views on the mind-body connection.

Dualism is defined as being born out of the body as a physical object, and the mind or the consciousness is being constructed. The origins of dualism started with the Cartesian ways of thinking, where people started to argue that there was a two-way relationship between the mental and physical substances in the body. Surprisingly, the belief of the physical and mental systems are compartmentalized and not inter-related like what some people think.

French philosopher Ren� Descartes stated that the mind interacts with the body through the pineal glands and that the mind controls the body. He also summed his thoughts with one of his famous statements: �I think therefore I am.� With this statement, it tells researchers that the mind is a nonphysical and non-spatial substance that is being identified with consciousness and self-awareness in the body.

With monism, it is defined as a material point of view and that all humans are just merely complex physiological organisms. There is another type of monism known as phenomenalism. It also goes by subject idealism, and the concept of this monism is that the mind and the body are two separate entities. With each type of monism, the concepts always seem to be the same, which shows that each type of monism seems to ignore either the mind or the body. It is always one or the other, never together at the same time.

How Stress Hormones Influences the Brain

When it comes to stress and hormones, there has been a lot of scientific advancements on how the stress hormone affects the brain in the body. Since hormones have been found to alter the hippocampal neurons with stress hormones, they can give the body the burst of energy that it needs. Although, if there is a long-term activation of the stress hormone can wear the brain down and kill the brain’s cells. If someone has any psychological disorders that cause prolonged stress, it can impair cognitive function, and the results can be enhanced emotionally.

Conclusion

With the mind-body connection, they can send signals to each other and make sure that the human body is functioning correctly. When there is prolonged stress in the body, it can disrupt the signals and cause the body to dysfunction. The next article will be discussing how stress can rewire the brain in the body. Some products can help the body by supporting the endocrine system as well as helping the body to relieve temporary stress.

The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.


References:

Perry, Bruce D., et al. �Childhood Trauma, the Neurobiology of Adaptation, and �Use?Dependent� Development of the Brain: How �States� Become �Traits.�� Semantic Scholar, 1 Jan. 1995, www.semanticscholar.org/paper/Childhood-trauma%2C-the-neurobiology-of-adaptation%2C-Perry-Pollard/1d6ef0f4601a9f437910deaabc09fd2ce2e2d31e.

Team, Biotics Education. �Stress – The Mind-Body Connection Part 1.� Biotics Research Blog, 9 Dec. 2019, blog.bioticsresearch.com/stress-the-mind-body-connection-part-1.

Woolley, C S, and P A Schwartzkroin. �Hormonal Effects on the Brain.� Epilepsia, U.S. National Library of Medicine, 1998, www.ncbi.nlm.nih.gov/pubmed/9915614.


Modern Integrative Medicine

Functional Endocrinology: The Hippocampus and Stress

Functional Endocrinology: The Hippocampus and Stress

Do you feel:

  • Stressed out?
  • Have uncontrollable weight gain?
  • Can you not remember specific stuff?
  • Agitated, jittery, anxious?
  • Inflammation?

If you are experiencing any of these situations, then your hippocampus might be lowered than usual.

The Hippocampus

In the brain, there is an S-shaped structured located in the inner folds in the temporal lobe called the hippocampus. The hippocampus is a complex brain structure that has a layer of densely packed neurons, and its primary function involves how humans learn and how their memory works. The hippocampus is part of the limbic system as well since it works the feeling and reacting function in the body. The limbic system is situated at the edge of the cortex and includes the hypothalamus and the amygdala.

Hippocampus-Brain-female-2-big-bigstock.jpg

These structures help controls the body�s different functions like the endocrine system and the �fight or flight� reaction response. With the hippocampus helping humans process what information they are learning, this structure can retrieve two kinds of memories that are important; they are declarative memories and spatial relationship memories.

  • Declarative memories: These are memories that are related to facts and events a person experience. It includes examples like how to memorize speeches or line in a play that a person is doing.
  • Spatial relationship memories: These memories involve pathways or routes that a person must learn. An example of this is transportation drivers like cab drivers, bus drivers, and truckers who have to learn the routes in the places they are going to. So they use spatial memory and practice their routes many times until they have it in their memories. The spatial relationship memories are stored on the right side of the hippocampus.

Sadly though, the hippocampus can be damaged by neurological diseases like Alzheimer�s disease and PTSD (Post-Traumatic Stress Disorder). When it is damaged, a variety of conditions can affect the hippocampus�s ability to do its job for the brain, thus making the individual suffer from retaining information.

Hippocampus Conditions

Several conditions can cause problems to the body when the hippocampus is damaged. This is known as hippocampus atrophy, where the neurons and neuronal volume in the hippocampal that is a loss.

Alzheimer�s Disease

Alzheimer�s disease is when an individual begins to lose their memory. When the hippocampus is damaged, it can cause a dissociation between the cortexes and leads to information registration failure. Studies show that when Alzheimer�s disease is progressing, the hippocampus will lose its volume, and it will become harder for an individual to function in their daily lives.

Epilepsy

When a person has epilepsy, it might be due to a damaged hippocampus. Research shows that around 50 to 75% of patients with this disease may have hippocampal sclerosis, and in case they have died, they have medial temporal lobe epilepsy. More research states that the mechanics of hippocampal sclerosis in epilepsy can be related to the development of inflammation on the uncontrolled local hippocampus and blood-brain barrier damage.

Hypertension

When the hippocampus is damaged, hypertension can happen to a person. Hypertension is another name for high blood pressure, and it can lead to severe health complications to the body. Even though the causes of hypertension are still unknown, the risk factors from hypertension can include:

  • Environmental factors like stress or a lack of exercise
  • Hormone activity
  • Blood plasma

Studies show that hypertension and other risk factors are being increasingly viewed as a putative factor that is leading to hippocampal atrophy.

Cushing�s Disease

Cushing�s disease or Cushing syndrome is when the body is exposed to high levels of cortisol for a long time. Studies show that when there is a loss of cellular volume to the corticosteroid�s levels in the body and it could be responsible. When there is too much cortisol being produced in the body, it is one of the signs of Cushing syndrome. Some of the other signs include:

  • Weight gain
  • Fatty tissue deposits around the midsection, face, upper back and between the shoulders
  • Pink or purple stretch marks
  • Thinning, fragile skin that bruises easily
  • Slow healing cuts, insect bites and infections
  • Acne
  • Muscle weakness
  • Cognitive difficulties
  • Loss of emotional control

Since stress does play a role in the endocrine system and the neurological system, there are nearly 80 years of research on how much focus has been on the various levels of the HPA (hypothalamic-pituitary-adrenal) axis and the hormones it produces. It shows that glucocorticoids as the mediators for the stress effects on the hippocampus and being the contributing factor for stress-associated psychopathologies.

Conclusion

The hippocampus is located in the temporal lobe of the brain. This S-shaped structure can be easily damaged due to stress and other neurological factors that can affect the entire body and its systems. When harmful factors affect the hippocampus, it can lead the hormones that are producing to become imbalanced and cause dysfunction. Some products are here to make sure that the endocrine system is functioning properly and supporting the metabolic system, the gastrointestinal system, as well as making sure the hormones are balanced.

The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.


References:

Anand, Kuljeet Singh, and Vikas Dhikav. �Hippocampus in Health and Disease: An Overview.� Annals of Indian Academy of Neurology, Medknow Publications & Media Pvt Ltd, Oct. 2012, www.ncbi.nlm.nih.gov/pmc/articles/PMC3548359/.

Dresden, Danielle. �Hippocampus: Function, Size, and Problems.� Medical News Today, MediLexicon International, 7 Dec. 2017, www.medicalnewstoday.com/articles/313295.php.

Felman, Adam. �Hypertension: Causes, Symptoms, and Treatments.� Medical News Today, MediLexicon International, 22 July 2019, www.medicalnewstoday.com/articles/150109.php.

Kim, Eun Joo, et al. �Stress Effects on the Hippocampus: a Critical Review.� Learning & Memory (Cold Spring Harbor, N.Y.), Cold Spring Harbor Laboratory Press, 18 Aug. 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC4561403/.

Team, Mayo Clinic. �Cushing Syndrome.� Mayo Clinic, Mayo Foundation for Medical Education and Research, 30 May 2019, www.mayoclinic.org/diseases-conditions/cushing-syndrome/symptoms-causes/syc-20351310.

 

 

Glycine: Astounding Role for Hormones and Sleep

Glycine: Astounding Role for Hormones and Sleep

Do you feel:

  • Inflammation?
  • Hormone imbalances?
  • Weight gain?
  • Brain fog?
  • Stomach pain, burning, or aching 1-4 hours after eating?

If you are experiencing any of these situations, then you might be experiencing low glycine levels in your body.

Glycine

Glycine

Glycine is a vital amino acid that is beneficial to the body. It helps support the gastrointestinal system, the neurological system, the musculoskeletal system, and the body�s metabolism from harmful factors that can cause the human body to malfunction. Glycine is even a neurotransmitter and can help increase glutathione in the brain by providing anti-inflammatory effects. Glycine provides a sweet taste when it is consumed in the body. Even though glycine has a crucial role in the human body, the amino acid has received little to no attention until recently.

The fantastic thing about glycine is that it is a “non-essential” amino acid. What this means is that the body can make glycine by itself and distribute it to the necessary systems that need glycine. This is different from the “essential” amino acids since some nutrients and vitamins must come from the food diet themselves. When there is a mild deficiency of glycine, it is not harmful to the body; however, when there is a severe shortage of glycine, it can lead to immune response failure, slow body growth, and abnormal nutrient metabolism.

Glycine for The Brain

Since glycine is a neurotransmitter for the brain, it composes both excitatory and inhibitory capacities. For the excitatory capacity function, glycine serves as the antagonist for NMDA receptors for the brain. For inhibitory capacities, glycine helps increase the neurotransmitter serotonin. Studies show that serotonin is the ancestor of melatonin. When the levels are increased due to glycine supplements, the beneficial factors it causes can help reduce insomnia and provide better sleep quality.

Glycine on Sleep

Despite being a massive impact on serotonin, glycine has been known to be used as a therapeutic option for individuals to improve their sleep quality as a novel and safe approach.� Studies show that glycine can increase the blood flow to extremities by reducing the body�s core temperature, which is an important signal to initiate sleep. When this happens, glycine can increase a person�s time when they are in REM sleep, providing the person to have a good night’s sleep. Further research shows that glycine can inhibit the stimulatory orexin neurons that are responsible for arousal and energy homeostasis, which is critical and can induce non-REM sleep or even night waking.

Glycine�s Cognitive Effects

There are many beneficial cognitive effects that glycine has to offer. Research shows that the beneficial effect of glycine can help improve episodic memory in young and middle-aged adults. This can be beneficial for patients who have schizophrenia, Parkinson’s disease, and Huntington’s disease. Additional research also shows that patients who have Alzheimer’s disease use glycine as energy production for their brains.

Glycine Osteoprotective Effects

There is even more information on glycine supplementation, providing estrogen-like osteoprotective effects for menopausal women. The research shows that glycine helps decreased weight gain and providing an increase in vaginal weight gain caused by ovariectomy. Many healthcare providers recommend their female patients that have menopause to use glycine in their diet.

More Glycine Effects

Since glycine is a non-essential amino acid and a neurotransmitter for the central nervous system, this supplement can help supple muscle, bone, and connective tissue with collagen. Glycine has a small R group, which forms a triple helix structure that makes up of tropocollagen. In the body, 33% of all collagen is composed of glycine. Collagen levels in the body can decrease naturally due to anyone getting old. When this happens, inflammatory symptoms like arthritis occur. Researchers hypothesize that supplemental doses of glycine can strengthen joints and prevent reactive arthritis by blunting cytokine release by increasing chloride influx in the body.

Glycine is one of the three amino acids that can help aid the production of glutathione for the human body. Since this amino acid is a scavenger antioxidant, it will oppose proinflammatory signals from hydrogen peroxide. Studies show that glycine supplementation plays a vital role in balancing the redox reactions caused by metabolic syndrome in the human body and protecting patients from oxidative damage. There is even more research as a study stated that glycine has a vital role in the metabolism and nutrition of mammals and humans. Since glycine protects from inflammation and has fantastic health benefits for the body, when there are decreased levels of glycine in the body, it can be linked to metabolism-related disorders like type 2 diabetes and fatty liver disease.

Glycine provides cytoprotective effects on the liver and gastrointestinal tract by conjugating bile acids. This is crucial because glycine plays a role in helping lipids to be digested and lipid-soluble vitamins to be absorbed in the body. In alcohol-induced hyperlipidemia, studies have shown that glycine can reduce alcohol levels in the bloodstream while also retaining the membrane integrity by reducing lipid levels. Glycine can even protect the stomach and intestines from damages caused by gastrointestinal disorders. Since glycine can maintain enterocyte integrity and prevent apoptosis, its anti-inflammatory effects can fight oxidative stress. They can provide the requirements to the intestines and the gut in the body.

Conclusion

Glycine is a vital amino acid that provides anti-inflammatory properties for not only the body’s metabolism but also helps the gastrointestinal system. With more and upcoming research about glycine, it is essential for this amino acid to continue to provide outstanding effects to the human body and to make sure that it functions properly. When harmful factors start entering the body, or there is a glycine deficiency, it can cause the body to malfunction. So incorporating glycine-rich foods in the daily diet can help alleviate the symptoms gradually. Some products are beneficial for the body since they help support the immune system and make sure the body is functioning.

The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.


References:

Bannai, Makoto, et al. �Oral Administration of Glycine Increases Extracellular Serotonin but Not Dopamine in the Prefrontal Cortex of Rats.� Wiley Online Library, John Wiley & Sons, Ltd (10.1111), 17 Mar. 2011, onlinelibrary.wiley.com/doi/full/10.1111/j.1440-1819.2010.02181.x.

D�az-Flores, Margarita, et al. �Oral Supplementation with Glycine Reduces Oxidative Stress in Patients with Metabolic Syndrome, Improving Their Systolic Blood Pressure.� Canadian Journal of Physiology and Pharmacology, U.S. National Library of Medicine, Oct. 2013, www.ncbi.nlm.nih.gov/pubmed/24144057.

File, S E, et al. �Beneficial Effects of Glycine (Bioglycin) on Memory and Attention in Young and Middle-Aged Adults.� Journal of Clinical Psychopharmacology, U.S. National Library of Medicine, Dec. 1999, www.ncbi.nlm.nih.gov/pubmed/10587285.

Griffin, Jeddidiah WD, and Patrick C Bradshaw. “Amino Acid Catabolism in Alzheimer’s Disease Brain: Friend or Foe?” Oxidative Medicine and Cellular Longevity, Hindawi Publishing Corporation, 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5316456/.

Kawai, Nobuhiro, et al. �The Sleep-Promoting and Hypothermic Effects of Glycine Are Mediated by NMDA Receptors in the Suprachiasmatic Nucleus.� Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, Nature Publishing Group, May 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC4397399/.

Kim, Min-Ho, et al. “Estrogen-like Osteoprotective Effects of Glycine in Vitro and in Vivo Models of Menopause.” Amino Acids, U.S. National Library of Medicine, Mar. 2016, www.ncbi.nlm.nih.gov/pubmed/26563333.

Li, X et al. “Dietary Glycine Prevents Peptidoglycan Polysaccharide-Induced Reactive Arthritis in the Rat: Role for Glycine-Gated Chloride Channel.” Infection and Immunity, American Society for Microbiology, Sept. 2001, www.ncbi.nlm.nih.gov/pmc/articles/PMC98707/.

McCarty, Mark F, et al. �Dietary Glycine Is Rate-Limiting for Glutathione Synthesis and May Have Broad Potential for Health Protection.� The Ochsner Journal, The Academic Division of Ochsner Clinic Foundation, 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC5855430/.

Razak, Meerza Abdul, et al. �Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review.� Oxidative Medicine and Cellular Longevity, Hindawi, 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5350494/.

Ross, Krista Anderson. �Glycine: Another Tool for the Hormone and Sleep Balancing Kit.� Doctor’s Data Specialty Testing Clinical Laboratory, 3 Dec. 2019, www.doctorsdata.com/resources/uploads/newsletters/Glycine’s-Role-in-Sleep-and-Hormone-Balancing.html.

 

Functional Endocrinology: Normalizing the Gut

Functional Endocrinology: Normalizing the Gut

Microbes have multicellular hosts and can have many effects on the host�s health and well-being. Researchers have stated that microbes influence metabolism, immunity, and behavior on the human body. One of the most important but understudied mechanisms that microbes have is that they can involve hormones. In the presence of gut microbiota, specific changes in hormone levels can correlate in the gut. The gut microbiota can produce and secrete hormones, respond to the host hormones, and regulate their expression levels. There is also a link between the endocrine system and the gut microbiota as more information is still being researched.

The Gut to Hormone Connection

Since the human microbiome contains a vast array of microbes and genes that shows a higher complexity. Unlike other organs in the body, the gut microbiota’s function is not fully understood yet but can be disrupted easily by antibiotics, diet, or surgery. The best-characterized function is how the gut microbiota interacts with the endocrine system in the body.

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Emerging research has indicated that the gut microbiome plays a central role in regulating estrogen levels within the body. When the estrogen hormone levels are too high or too low, it can lead to the risk of developing estrogen-related diseases like endometriosis, polycystic ovary syndrome, breast cancer, and prostate cancer to males and females.

The gut to hormone connection is essential since the gut is one of the producers to create hormones that travel through the entire body system. With the endocrine system is being involved, it is the first network to produce and transport hormones to the organs that need the hormones to function. When there is an imbalance of hormones in the human body, it can disrupt all the other hormones.

The gut microbiota influences nearly every hormone that the endocrine system creates, including:

  • The thyroid hormones
  • Estrogen hormones
  • Stress hormones

Thyroid Hormones

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If the gut has inflammation, then the hormones in the body will create an excessive or low quantity in the body. If the endocrine glands like thyroid, are producing a low quantity of hormones and the gut can be imbalanced and lead to hypothyroidism. When there is low microbial diversity in the gut, studies have shown that the low microbial diversity is linked to high TSH (thyroid-stimulating hormone) levels. The excessive quantity of thyroid hormones can lead to hyperthyroidism. Both hyperthyroidism and hypothyroidism can cause symptoms like irritability, anxiety, poor memory, and many symptoms that can affect the body.

“If you are experiencing excessive belching, burping, bloating, difficult bowel movements difficulty digesting proteins and meats; undigested food found in stools, digestive problems subside with rest and relaxation or any symptoms. Then this article will give you a better understand what is happening with the gut and how hormones can affect the gut system.”

Estrogen Hormones

The gut and an individual’s hormones are meant to be in communication with each other. They not only support each other, but they also work together to make sure the body is running smoothly. Studies have found out that the gut’s intestinal cells have special receptors for hormones that allow them to detect any hormonal shifts that affect the body.

Since estrogen is typically associated with women, it is common that men need the right amount of estrogen levels to function. The gut microbiota is the key regulator of leveling and circulating estrogen in the body. The microbes produce an enzyme called beta-glucuronidase, which then converts the estrogen hormone to its active form.

The gut microbiome can regulate estrogen levels by functioning a specific bacteria in the microbiome called estrobolome. Estrobolome is the aggregates of enteric bacterial genes that are capable of metabolizing estrogen. It might affect women’s risk of developing postmenopausal estrogen receptor-positive breast cancer. The estrobolome is highly essential to keep estrogen levels in the body at a stable state.

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In the gut microbiota, both the estrogen and progesterone hormones can impact the guts’ motility and peristalsis ( The rhythmic movement of the intestines that move food through the stomach and out of the body) by playing opposing roles in the guts� motility. Progesterone helps slow down the gut�s motility by relaxing the smooth and slowing transit the time the food is moving out of the body. Estrogen helps increase the contraction of the smooth muscles in the intestines. When the estrogen hormones are leveled right, it can help keep the gut moving smoothly and help increase the diversity of the body�s microbiomes, which is a good thing for the immune system.

Stress Hormones

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Stress hormones or cortisol plays a massive part in the gut microbiota. Since cortisol hormones connect to the brain, it sends the signals to the gut and vice versa. If it is a short stressor like getting ready for a presentation or a job interview, the person will feel “butterflies” in their gut. The longer stressors, for example, like having a highly stressful job or feeling anxious consistently, can lead to chronic illnesses in the gut like inflammation or leaky gut. Since the hormone and gut connection is in sync with the gut and brain connection, it is crucial to lowering the cortisol levels to a stable state for a healthy functional body.

Conclusion

The gut and hormone connections are profoundly meaningful since they are linked closely together. When there is a disruption on the gut, it can cause hormones to be imbalanced, causing many disruptions like inflammation and leaky gut. When there is a disruption in the hormones, it can disrupt the gut as well by negatively shifting the gut’s microbiome. So to ensure that the gut is functioning correctly, it is crucial to eat food that contains probiotics and is fermented to keep the gut flora healthy. Some products can help counter the metabolic effects of temporary stress and supporting estrogen metabolism by incorporating other essential nutrients and cofactors to support the endocrine system.

October is Chiropractic Health Month. To learn more about it, check out Governor Abbott�s declaration on our website to get full details on this historic moment.

The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or chronic disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .


References:

Author, Guest. �How Your Gut Microbiome Influences Your Hormones.� Bulletproof, 21 Aug. 2019, www.bulletproof.com/gut-health/gut-microbiome-hormones/.

Evans, James M, et al. �The Gut Microbiome: the Role of a Virtual Organ in the Endocrinology of the Host.� The Journal of Endocrinology, U.S. National Library of Medicine, 28 Aug. 2013, www.ncbi.nlm.nih.gov/pubmed/23833275.

Kresser, Chris. �The Gut�Hormone Connection: How Gut Microbes Influence Estrogen Levels.� Kresser Institute, Kresserinstitute.com, 10 Oct. 2019, kresserinstitute.com/gut-hormone-connection-gut-microbes-influence-estrogen-levels/.

Kwa, Maryann, et al. �The Intestinal Microbiome and Estrogen Receptor-Positive Female Breast Cancer.� Journal of the National Cancer Institute, Oxford University Press, 22 Apr. 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC5017946/.

Neuman, Hadar, et al. �Microbial Endocrinology: the Interplay between the Microbiota and the Endocrine System.� OUP Academic, Oxford University Press, 20 Feb. 2015, academic.oup.com/femsre/article/39/4/509/2467625.

Publishing, Harvard Health. �The Gut-Brain Connection.� Harvard Health, 2018, www.health.harvard.edu/diseases-and-conditions/the-gut-brain-connection.

Szkudlinski, Mariusz W, et al. �Thyroid-Stimulating Hormone and Thyroid-Stimulating Hormone Receptor Structure-Function Relationships.� Physiological Reviews, U.S. National Library of Medicine, Apr. 2002, www.ncbi.nlm.nih.gov/pubmed/11917095.

Wieselman, Brie. �Why Your Gut Health and Microbiome Make-or-Break Your Hormone Balance.� Brie Wieselman, 28 Sept. 2018, briewieselman.com/why-your-gut-health-and-microbiome-make-or-break-your-hormone-balance/.

 

 

Functional Endocrinology: Endocrine Disruptors

Functional Endocrinology: Endocrine Disruptors

Endocrine disruptors are chemicals that may interfere with the body’s endocrine system and produce adverse developmental, reproductive, neurological, and immune effects in humans. It can be pesticides, plasticizers, antimicrobials, and flame retardants that can be EDCs. EDCs (endocrine-disrupting chemicals) can disrupt the hormonal balance and can result in developmental and reproductive abnormalities in the body.

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There are four points about endocrine disruption:

  • Low dose matters
  • Wide range of health benefits
  • Persistence of biological effects
  • Ubiquitous exposure

EDC can cause significant risks to humans by targeting different organs and systems in the body. The interactions and the mechanisms of toxicity created by EDC and environmental factors can be concerning a person’s general health problems. Including endocrine disturbances in the body since many factors can cause endocrine disruptors, one of the disruptors in the food contaminated with PBDEs (polybrominated diphenyl esters) in fish meat and dairy.

Researchers also pointed out that once the contaminated foods eliminated from a person’s diet, then the endocrine disruptors decline, and the body began to heal properly. When a person eliminates the food that is causing discomfort to their bodies, they are more aware of reading the food labels to prevent discomfort anymore to the body systems.

Obesogen

Obesogen is a subclass of endocrine-disrupting chemicals (EDC) that might predispose individuals to the development of obesity. Their structure is mainly lipophilic, and they can increase fat deposition. Since the fat cell’s primary role is to store and release energy, researchers have found that different obesogenic compounds may have different mechanisms of action.

Some of these actions can affect the number of fat cells that are producing, while others affect the size of the fat cells, and some obesogenic compounds can affect the hormones. These compounds will affect the appetite, satiety, food preferences, and energy metabolism when the endocrine system plays a fundamental role in the body to regulate the metabolism of fats, carbohydrates, and proteins. Any alternations in the body can result in an imbalance in the metabolism and causing endocrine disorders.

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Studies even stated that exposure to obesogens could be found either before birth on utero or in the neonatal period. Obesogens can even cause a decrease in male fertility. When this disruption happens to the male body, environmental compounds can cause a predispose to weight gain, and obesogens can appoint as one of the contributors because of their actions as endocrine disruptors. Obesogens can even change the functioning of the male reproductive axis and testicular physiology. The metabolism in the male human body can be pivotal for spermatogenesis due to these changes.

Endocrine Disruptors and Obesity

Some endocrine disruptors that can affect the body can be through pharmaceutical drugs that can cause weight gain. A variety of prescription drugs can have an adverse effect that can result in weight gain since the chemicals found in prescription drugs have similar structures, and modes of action might have a role in obesity. Prescription medicine can stimulate the gut to consume more food, thus involving the body to gain weight.

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Another endocrine disruptor is PAHs (polycyclic aromatic hydrocarbons). These are a family of environmental chemicals that occur in oil, coal, and tar deposits. They produce as by-products of fuel-burning like fossil fuel, biomass, cigarette smoke, and diesel exhaust. PAHs can either be manufactured to be used as medicines and pesticides or be released naturally from forest fires and volcanoes.

There are standard ways a person can be exposed to PAHs. One is through eating grilled, charred, or charcoal-broiled meats that a person eats. The other is through inhalation of smoke from cigarettes, vehicle exhaust, or emissions from fossil fuels that can irritate the eyes and breathing passageways in the body.

Coping with EDC Exposure

Even though obesity can adversely affect the body in a variety of health outcomes, there are ways to cope and minimize the exposure of EDC. Research shows that a person can minimize EDC exposure by consuming organic fruits, vegetables, and grain products insofar as possible. This includes an increasing number of fungicides routinely applied to fruits and vegetables that are being identified as obesogens and metabolic disruptors in the body.

Xenoestrogen vs. Phytoestrogen

When a person has an endocrine disorder, it might be due to the food they are consuming. Phytoestrogens are plant-derived compounds that are in a wide variety of food, mostly in soy. They are presented in numerous dietary supplements and widely marketed as a natural alternative to estrogen replacement therapy.

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There is a health impact on phytoestrogen, and the plant-derived compound can either mimic, modulate, or disrupt the actions of endogenous estrogen. Xenoestrogen�are synthetically derived chemical agents from certain drugs, pesticides, and industrial by-products that mimic endogenous hormones or can interfere with endocrine disruptors. These chemical compounds can cause an effect on several developmental anomalies to humans. It can also interfere with the production and metabolism of ovarian estrogen in females.

Conclusion

Endocrine disruptors can interfere with the body’s endocrine system causing a health risk to an individual. EDC (endocrine-disrupting chemicals) can target many different organs and systems of the body by various factors that the human body is being exposed to. One of the EDC factors is obesogen, and it can cause a person to gain weight and be obese. Another factor is the exposure of PAHs (polycyclic aromatic hydrocarbons) through environmental factors like smoke inhalation or consuming charcoal-broiled meats. There are ways to cope with EDC exposure, and one is eating organic foods, especially fresh fruits and vegetables. Another is products that target the endocrine system and helps support the liver, intestines, body metabolism, and estrogen metabolism to ensure not only a healthy endocrine system but also a healthy body to function correctly.

October is Chiropractic Health Month. To learn more about it, check out Governor Abbott’s proclamation on our website to get full details on this historic event.

The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or chronic disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .


References:

Cardoso, A M, et al. �Obesogens and Male Fertility.� Obesity Reviews : an Official Journal of the International Association for the Study of Obesity, U.S. National Library of Medicine, Jan. 2017, www.ncbi.nlm.nih.gov/pubmed/27776203.

Darbre, Philippa D. �Endocrine Disruptors and Obesity.� Current Obesity Reports, Springer US, Mar. 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5359373/.

Holtcamp, Wendee. �Obesogens: an Environmental Link to Obesity.� Environmental Health Perspectives, National Institute of Environmental Health Sciences, Feb. 2012, www.ncbi.nlm.nih.gov/pmc/articles/PMC3279464/.

Janesick, Amanda S, and Bruce Blumberg. �Obesogens: an Emerging Threat to Public Health.� American Journal of Obstetrics and Gynecology, U.S. National Library of Medicine, May 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC4851574/.

Janesick, Amanda S, and Bruce Blumberg. �Obesogens: an Emerging Threat to Public Health.� American Journal of Obstetrics and Gynecology, U.S. National Library of Medicine, May 2016, www.ncbi.nlm.nih.gov/pubmed/26829510.

Kyle, Ted, and Bonnie Kuehl. �Prescription Medications & Weight Gain.� Obesity Action Coalition, 2013, www.obesityaction.org/community/article-library/prescription-medications-weight-gain/.

L�r�nd, T, et al. �Hormonal Action of Plant Derived and Anthropogenic Non-Steroidal Estrogenic Compounds: Phytoestrogens and Xenoestrogens.� Current Medicinal Chemistry, U.S. National Library of Medicine, 2010, www.ncbi.nlm.nih.gov/pubmed/20738246.

Patisaul, Heather B, and Wendy Jefferson. �The Pros and Cons of Phytoestrogens.� Frontiers in Neuroendocrinology, U.S. National Library of Medicine, Oct. 2010, www.ncbi.nlm.nih.gov/pmc/articles/PMC3074428/.

Singleton, David W, and Sohaib A Khan. �Xenoestrogen Exposure and Mechanisms of Endocrine Disruption.� Frontiers in Bioscience : a Journal and Virtual Library, U.S. National Library of Medicine, 1 Jan. 2003, www.ncbi.nlm.nih.gov/pubmed/12456297.

Unknown, Unknown. �Endocrine Disruptors.� National Institute of Environmental Health Sciences, U.S. Department of Health and Human Services, 2015, www.niehs.nih.gov/health/topics/agents/endocrine/index.cfm.

Unknown, Unknown. �Polycyclic Aromatic Hydrocarbons (PAHs): Your Environment, Your Health | National Library of Medicine.� U.S. National Library of Medicine, National Institutes of Health, 31 Apr. 2017, toxtown.nlm.nih.gov/chemicals-and-contaminants/polycyclic-aromatic-hydrocarbons-pahs.

Yang, Oneyeol, et al. �Endocrine-Disrupting Chemicals: Review of Toxicological Mechanisms Using Molecular Pathway Analysis.� Journal of Cancer Prevention, Korean Society of Cancer Prevention, 30 Mar. 2015, www.jcpjournal.org/journal/view.html?doi=10.15430%2FJCP.2015.20.1.12.

Functional Endocrinology: Hepatic Biotransformation & Hormone Balance

Functional Endocrinology: Hepatic Biotransformation & Hormone Balance

Biotransformation is the process of a substance changes from one chemical to another being transformed by a chemical reaction within the body. In the human body though, biotransformation is the process of rendering nonpolar (fat-soluble) compounds to polar (water-soluble) substances so they can be excreted in urine, feces, and sweat. It also serves as an important defense mechanism in the body to eliminate toxic xenobiotics out of the body through the liver. The liver is the one that takes these toxins and transformed them into suitable compounds to excrete out of the body as biotransformation.

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Detoxification is also known as �detoxication� in literature. It is also a type of alternative medicine treatment that aims the body to get rid of unspecified �toxins.� It is highly important for a person to detox their body and with biotransformation, it can be classified into two categories, under normal sequences, which tends to react with a xenobiotic. They are called Phase 1 and Phase 2 reactions that help the body with detoxification.

Phase 1 Reactions

Phase 1 reaction is consisting of oxidation-reduction and hydrolysis. Research shows that Phase 1 is generally the first defense employed by the body to biotransform xenobiotics, steroid hormones, and pharmaceuticals. They create CYP450 (cytochrome P450) enzymes and are described as functionalization microsomal membrane-bound that are located in the liver but can also be in enterocytes, kidney, lungs and the brain in the body. The CYP450 enzymes can be beneficial or have consequences for an individual�s response to the effect of a toxin they are exposed to.

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Studies have been shown that phase 1 reactions have been affecting the elderly population. It states that hepatic phase 1 reaction involving oxidation, hydrolysis, and reduction appears to be more altered by age since the elderly population comprises the fastest-growing segment of the world�s population. It also states that there is a predictable, age-related decline in cytochrome P-540 function and combined with the polypharmacy that much of the elderly population experiences, this may lead to a toxic reaction of medication.

Phase 2 Reaction

Phase 2 reaction is part of the cellular biotransformation machinery and is a conjugation reaction in the body. They can involve the transfer of a number of hydrophilic compounds to enhanced the metabolites, and the excretion in the bile or urine in the body. The enzymes in Phase 2 reaction can also comprise multiple proteins and subfamilies to play an essential role in eliminating the biotransformed toxins and metabolizing steroid hormones and bilirubin in the body.

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Phase 2 enzymes can function not only in the liver but also in other tissues like the small intestines. When it combined with Phase 1, they can help the body naturally detox the toxins that the body may encounter. Hormones, toxins, and drugs undergo a hepatic transformation by Phase 1 and Phase 2 pathways in the liver, then are eliminated by phase 3 pathways.

Xenobiotics

Xenobiotics has been defined as chemicals that undergo metabolism and detoxication to produce numerous metabolites, some of which have the potential to cause unintended effects such as toxicity. They can also block the action of enzymes or receptors used for endogenous metabolism and produce liver damage to a person. Xenobiotics like drugs, chemotherapy, food additives, and environmental pollutants can generate serval free radicals that lead to an increase of oxidative stress in the cells. Accumulation of oxidative stress in the body can lead to an increase in potential cellular reduction in the body.

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Research shows that the body has a major challenge when it is detoxifying xenobiotics out of the body system and the body must be able to remove the almost-limitless number of the xenobiotic compounds from the complex mixture of chemicals that are involved in normal metabolism.

Studies even show that if the body doesn�t have a normal metabolism, many xenobiotics would reach toxic concentrations. It can even reach the respiratory tract either through airborne toxins or the bloodstream. It is important to make sure that the body and especially the liver to be healthy. Since the liver is the largest internal organ, it is responsible for detoxifying the toxins out of the body as urine, bile, and sweat.

Conclusion

Biotransformation is the process of substance changes from one chemical to another. In the body, it is a process of rendering fat-soluble compounds to water-soluble compounds, so it can be excreted out of the body as either urine, feces, or sweat. The liver is the one that causes toxic xenobiotics to transform into biotransformation and going through phase 1 and 2 to excrete the toxins out of the body for a healthy function.

Phase 1 reactions in the body are the first line of defense of the body detoxifying itself. Phase 2 creates CYP450 (cytochrome P450) that helps the body take the xenobiotic toxins and oxidates to reduce and hydrolysis the toxins to metabolites. Those metabolites then transform into Phase 2 reactions, which conjugates the metabolites in the body to be excreted out of the body. There are many factors that can make the body have xenobiotics, but the liver is the main organ to detoxify the xenobiotics out of the system. If there is an abundance of xenobiotics in the body, it can cause toxicity reaction causing the body to develop chronic illnesses. These products are known to help support the intestines and liver detoxication as well as, to help support hepatic detoxication for optimal healthy body function.

October is Chiropractic Health Month. To learn more about it, check out Governor Abbott�s bill on our website to get full details.

The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or chronic disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .


References:

Chang, Jyh-Lurn, et al. �UGT1A1 Polymorphism Is Associated with Serum Bilirubin Concentrations in a Randomized, Controlled, Fruit and Vegetable Feeding Trial.� The Journal of Nutrition, U.S. National Library of Medicine, Apr. 2007, www.ncbi.nlm.nih.gov/pubmed/17374650/.

Croom, Edward. �Metabolism of Xenobiotics of Human Environments.� Progress in Molecular Biology and Translational Science, U.S. National Library of Medicine, 2012, www.ncbi.nlm.nih.gov/pubmed/22974737.

Hindawi, Unknown. �Xenobiotics, Oxidative Stress, and Antioxidants.� Xenobiotics, Oxidative Stress, and Antioxidants, 17 Nov. 2017, www.hindawi.com/journals/omcl/si/346976/cfp/.

Hodges, Romilly E, and Deanna M Minich. �Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review with Clinical Application.� Journal of Nutrition and Metabolism, Hindawi Publishing Corporation, 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC4488002/.

Kaye, Alan D, et al. �Pain Management in the Elderly Population: a Review.� The Ochsner Journal, The Academic Division of Ochsner Clinic Foundation, 2010, www.ncbi.nlm.nih.gov/pmc/articles/PMC3096211/.

M.Haschek, Wanda, et al. �Respiratory System.� ScienceDirect, Academic Press, 17 Dec. 2009, www.sciencedirect.com/science/article/pii/B9780123704696000064.

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Functional Endocrinology: Prostaglandin Balance

Functional Endocrinology: Prostaglandin Balance

Prostaglandins are different than hormones. They are not secreted from a gland that can be carried through the bloodstream and work on specific areas around the body. Prostaglandins are made by a chemical reaction in the body that can be made in all the organs and are part of the body�s way of dealing with injuries and illnesses.

When any part of the body has been damaged, prostaglandins are made at the site of tissue damage or infection where they cause inflammation, pain and fever as part of the body�s healing process. When there is a high level of prostaglandins in the body due to the natural healing process from injuries and inflammation, it can contribute to several diseases from the unwanted inflammation.

Prostaglandins in the Omega fatty acids

In omega-6 fatty acids, DGLA (dihomo-gamma-linolenic acid) creates Prostaglandin E1(PG-1) as anti-inflammatory receptors in the body. In omega-3 fatty acids, they can create Prostaglandin E3 (PG-3) that are also anti-inflammatory receptors as well. PG-1 and PG-3 help prevent blood clotting in the body system.

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When it comes to pro-inflammatory receptors, omega-6 fatty acids have these receptors as well. Pro-inflammatory receptors are created by arachidonic acid. Arachidonic acid creates Prostaglandin E2 (PG-2), which is responsible for inflammation, swelling and clotting as well.

There has to be a balance between PG-2 and PG-1,3 to provide a healthy function in the body and an ideal hormone signaling response. When one of the PGs are being disrupted by trans-fatty acids from food, it can cause health problems to a person.

Deficiencies in Prostaglandins

Trans fatty acids are a form of unsaturated fats that can be either natural or artificial. They are produced either by hydrogenation of unsaturated oils or by biohydrogenation in the stomach of ruminant animals. Numerous studies have been shown that consuming trans fatty acids continuously can increase the risk of cardiovascular diseases. This can also increase the ratio of LDL cholesterol to HDL cholesterol in the body. Trans fatty acids can block the activity of D6D (delta-6-desaturase), which is the first step in prostaglandin synthesis from essential fats in the diet.

The excess sugar consumption, insulin surges, inflammation, protein deficiencies hypothyroidism, and alcohol consumption will impair the activity of D6D and be a marker of accelerating aging to the human body. When a person has an increased consumption from fried foods and vegetable oils in an Western diet will shift the omega-6 pathway from PG-1 and into PG-2 production in the body. With the current American diet, people consume a high quantity of omega-6 fatty acids and low quantity of omega-3 fatty acids. This will cause a strong reaction of an inflammatory prostaglandin shift.

Since prostaglandins are caused by injuries and inflammation to heal the body, when an individual consumes a high omega-6 diet, it can cause an excessive amount of inflammation to the body and it can lead to chronic illnesses.

More Deficiencies in Prostaglandins

A deficiency in nutrients like nicotinic acid, pyridoxal 5� -phosphate, calcium, magnesium, zinc, and molybdenum is required for the desaturase and elongase enzymes in omega-6 and omega-3 fatty acids. Their deficiency can lead to improper production of prostaglandins. So EFAs from diets cause overconsumption of omega-6 and a lack of essential fatty acids in the body.

After that happens, then the EFAs can be synthesized into prostaglandins with desaturase and elongase enzymes. This will then cause nutrient deficiencies and metabolic factors can impair and downregulate those enzymes and causing the body to be prone to pro-inflammatory.

When that happens, prostaglandin formation will suddenly turn into abnormal ratios in the body causing problems, excessive inflammation in the endocrine glands and the body organs, and soon later on if it is not fixed, chronic illnesses will cause proper hormones to alter their components and either stop producing or create an abundance in the body.

Conclusion

Prostaglandins are a chemical reaction to the body that are different than hormones. They are caused when the body is injured and it causes inflammation so it can naturally heal itself. When there is an excessive amount of prostaglandins in the body it can lead to chronic inflammation and cause an abnormal shift in the body�s functional state. A factor that can affect the prostaglandins as well is the excessive consumption of omega-6 fatty acids. This consumption can cause inflammation and can make the body feel sluggish and not feeling great. There are products that can help the body, especially balancing the production of essential fatty acids and metabolizing the body for optimal health.

October is Chiropractic Health Month. To learn more about it, check out Governor Abbott�s bill on our website to get full details.

The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or chronic disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .


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Innes, Jacqueline K, and Philip C Calder. �Omega-6 Fatty Acids and Inflammation.� Prostaglandins, Leukotrienes, and Essential Fatty Acids, U.S. National Library of Medicine, May 2018, www.ncbi.nlm.nih.gov/pubmed/29610056.

Iqbal, Mohammad Perwaiz. �Trans Fatty Acids – A Risk Factor for Cardiovascular Disease.� Pakistan Journal of Medical Sciences, Professional Medical Publicaitons, Jan. 2014, www.ncbi.nlm.nih.gov/pmc/articles/PMC3955571/.

Leech, Joe. �What Are Trans Fats, and Are They Bad for You?� Healthline, 30 July 2019, www.healthline.com/nutrition/why-trans-fats-are-bad.

Ricciotti, Emanuela, and Garret A FitzGerald. �Prostaglandins and Inflammation.� Arteriosclerosis, Thrombosis, and Vascular Biology, U.S. National Library of Medicine, May 2011, www.ncbi.nlm.nih.gov/pmc/articles/PMC3081099/.

Tallima, Hatem, and Rashika El Ridi. �Arachidonic Acid: Physiological Roles and Potential Health Benefits – A Review.� Journal of Advanced Research, Elsevier, 24 Nov. 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC6052655/.

Unknown, Unknown. �Prostaglandins.� You and Your Hormones, Dec. 2016, www.yourhormones.info/hormones/prostaglandins/.

Wang, Xiaoping, et al. �Multiple Roles of Dihomo-?-Linolenic Acid against Proliferation Diseases.� Lipids in Health and Disease, BioMed Central, 14 Feb. 2012, www.ncbi.nlm.nih.gov/pmc/articles/PMC3295719/.