Nutrition is considered to be one of the most well-understood environmental factors associated with changes in the epigenome. Nutrients in the foods we eat are processed by our metabolism and turned into energy. One metabolic pathway, however, is responsible for producing methyl groups or fundamental epigenetic marks that regulate our gene expression. Essential nutrients, such as B vitamins, SAM-e (S-Adenosyl methionine), and folic acid are important components in this methylation process. Diets with high amounts of these essential nutrients can quickly change gene expression, especially during early development. In the following article, we will discuss the connection between nutrition and the epigenome.
Contents
Nutrigenomics and Health
Healthcare professionals discuss that when it comes to dealing with health issues like inflammation and chronic pain, understanding how nutrigenomics affects our overall health is important. Nutritional genomics, or nutrigenomics, is a science that studies the relationship between nutrition, health, and the genome. Researchers in the nutrigenomics field believe that changes in epigenetic marks may be associated with a variety of health issues, including inflammation or the development of diseases like obesity, heart problems, and cancer. Studies have demonstrated that we may be able to control the effects of the nutrients we eat in order to change gene expression associated with various health issues.
Approximately more than 1 out of 3 adults in the United States have been diagnosed with obesity which ultimately increases the risk of a variety of health issues, including prediabetes and type 2 diabetes, among other diseases. Previous studies have demonstrated that changes in epigenetic marks during early development may even predispose individuals to obesity. Moreover, changes in epigenetic marks were also demonstrated to affect metabolic pathways that may increase the risk of prediabetes and type 2 diabetes. Healthcare professionals in the nutrigenomics field have created new ways to be able to better find balance through a wholesome understanding of nutrition and the epigenome.
“An epigenetic test can provide data that is useful for healthcare professionals. It may also offer information about how certain metabolic pathways are affected by essential nutrients, such as vitamins and minerals”.
What is the Epigenetics Diet?
The term “epigenetics diet” was first coined by Dr. Trygve Tollefsbol in 2011. It is medically defined as a group of compounds, such as resveratrol in red grapes, genistein in soybeans, isothiocyanates in broccoli, and many other well-known types of foods, which have been demonstrated to help change epigenomic marks and gene expression. According to researchers, the epigenetics diet can prevent the progression of tumors by regulating enzymes that control these epigenomic marks and gene expression, including DNA methyltransferases, histone deacetylases, and certain non-coding RNAs. Several types of foods included in the epigenetics diet are demonstrated in the following infographic:
Researchers used recently advanced technologies that demonstrated how several bioactive compounds may aggravate damage to the epigenome caused by environmental pollutions. By way of instance, dietary supplementation with methyl donors, such as vitamin B12, choline, and folate, among others, as well as the isoflavone genistein, can regulate changes to epigenome marks and gene expression caused by bisphenol A, a hormone-disrupting chemical. B vitamins may also prevent the loss of DNA methylation caused by air pollution. According to these same studies, dietary supplementation with folic acid has also been demonstrated to help prevent the negative side-effects caused by heavy metals.
We believe that foods in the epigenetics diet could be used to counteract changes to gene expression and epigenomic marks caused by environmental pollution. Environmental pollutants in several types of foods, such as pesticides in fruits like strawberries and leafy greens like spinach, bisphenol A in the plastic containers of foods and drinks, dioxins in fatty foods, polycyclic aromatic hydrocarbons produced when meat is grilled or smoked at high temperatures, and mercury in several types of seafood like king mackerel and swordfish, have been associated with changes to epigenomic marks and gene expression. Those exposures, especially during early development, may cause various health issues.
For more information regarding the connection between nutrition and the epigenome, please review this article:
Nutrition is one of the most understood environmental factors associated with changes in epigenomic marks and gene expression. Essential nutrients found in the different types of foods we eat are metabolized and turned into molecules in order to be used for energy by the human body. One metabolic pathway is responsible for creating methyl groups, important epigenetic marks that regulate our gene expression and epigenomic marks. Essential nutrients, including B vitamins, SAM-e (S-Adenosyl methionine), and folic acid are fundamental components in DNA methylation. Diets that are rich in these essential nutrients can quickly change epigenetic marks and gene expression, especially during early development. Furthermore, adding a variety of good foods to a smoothie can be a fast and easy way to add essential nutrients to your diet. Below is a fast and easy smoothie recipe to help feed your genes. – Dr. Alex Jimenez D.C., C.C.S.T. Insights
Ginger Greens Juice
Servings: 1 Cook time: 5-10 minutes
� 1 cup pineapple cubes
� 1 apples, sliced
� 1-inch knob of ginger, rinsed, peeled and chopped
� 3 cups kale, rinsed and roughly chopped or ripped
� 5 cups Swiss chard, rinsed and roughly chopped or ripped
Juice all ingredients in a high-quality juicer. Best served immediately.
Add Nasturtium to Your Smoothies
Adding nasturtium flowers and leaves to any smoothie can add extra nutrients. These lovely plants are easy to grow and the entire plant is edible. Nasturtium leaves are high in vitamin C, which is essential for a healthy immune system, and they also contain calcium, potassium, phosphorus, zinc, copper, and iron. According to healthcare professionals, the extract from the flowers and leaves have antimicrobial, antifungal, hypotensive, expectorant, and anticancer effects. Antioxidants in garden nasturtium occur due to its high content of compounds such as anthocyanins, polyphenols, and vitamin C. Due to its rich phytochemical content and unique elemental composition, the garden nasturtium may be used in the treatment of a variety of health issues, including respiratory and digestive problems. Not to mention, the flowers and leaves look absolutely lovely in smoothies.
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask�Dr. Alex Jimenez�or contact us at�915-850-0900.
Curated by Dr. Alex Jimenez D.C., C.C.S.T.
References:
Kirkpatrick, Bailey. �Epigenetics, Nutrition, and Our Health: How What We Eat Could Affect Tags on Our DNA.� What Is Epigenetics?, What Is Epigenetics? Media, 11 May 2018, www.whatisepigenetics.com/epigenetics-nutrition-health-eat-affect-tags-dna/.
Li, Shizhao, et al. �The Epigenetics Diet: A Barrier against Environmental Pollution.� On Biology, BMC Media, 23 May 2019, blogs.biomedcentral.com/on-biology/2019/05/20/the-epigenetics-diet-a-barrier-against-environmental-pollution/.
Insulin is an essential hormone that regulates blood sugar levels. It is naturally produced in the pancreas and helps move excess glucose from the bloodstream into the cells to be used for energy. When the pancreas recognizes high blood sugar levels, it creates more insulin to reduce glucose. However, this can diminish the pancreas of insulin-producing cells which can eventually cause insulin resistance or impaired insulin sensitivity. If the pancreas can’t produce enough insulin, it can lead to prediabetes or type 2 diabetes. In the following article, we will discuss natural ways to improve insulin resistance or impaired insulin sensitivity to prevent and regulate prediabetes and type 2 diabetes, among other health issues.
Contents
Foods to Avoid with Insulin Resistance
If you have insulin resistance or impaired insulin sensitivity associated with prediabetes, type 2 diabetes, or any other health issue, there are several types of foods that can increase blood sugar levels. Frequently eating foods with high glucose content can diminish the insulin-producing cells that can ultimately affect the human body’s ability to produce enough insulin. When this occurs, high blood sugar levels remain elevated which can ultimately cause prediabetes and type 2 diabetes as well as lead to a variety of other health issues, including damage to organs such as the eyes and kidneys or limbs (neuropathy). Avoid eating the following types of foods if you have insulin resistance or impaired insulin sensitivity:
fried foods
processed snacks and foods
dairy products from cows, such as milk
foods high in saturated fats, such as butter, and salt pork
refined grains, such as white rice, pasta, bread, and flour-based foods
sugary sweets and pastries, such as ice cream, chocolate bars, and cupcakes
starchy vegetables, such as corn, potatoes and yams (without skin), and pumpkin
sweetened drinks or beverages, such as fruit juices, fountain drinks, and sodas
alcohol, such as beer and grain alcohol, in large quantities
Foods to Eat with Insulin Resistance
Many people are commonly deficient in essential nutrients, such as calcium, potassium, magnesium, and fiber. These nutrients are necessary for regulating blood sugar levels. People with insulin resistance or impaired insulin sensitivity, or any other health issue, including prediabetes or type 2 diabetes, should eat foods that have plenty of these essential nutrients. According to the American Diabetes Association, people with insulin resistance or impaired insulin sensitivity can eat from any of the basic food groups, however, it’s fundamental for individuals to understand which types of foods can increase blood glucose levels. Eat from the following types of foods if you have insulin resistance or impaired insulin sensitivity:
antioxidant-rich foods, such as berries
citrus fruits, such as oranges, lemons, and limes
non-starchy vegetables, such as dark leafy greens, peppers, and broccoli
protein-rich foods, such as legumes, nuts, soy, fish, and lean meats
high-fiber foods, including beans, and lentils
omega-3 fatty acid-rich foods, such as sardines, herring, and salmon
certain types of whole grains, such as oats, quinoa, and barley
water, especially as a substitute for sweetened drinks and
unsweetened teas
Exercise to Improve Insulin Resistance
Eating good foods and avoiding bad foods can help improve insulin resistance or impaired insulin sensitivity, however, there’s another natural way to improve this health issue: exercise. Participating and engaging in regular exercise helps improve insulin resistance or impaired insulin sensitivity associated with prediabetes and type 2 diabetes, among other health issues, by moving sugar from the bloodstream into the muscles to be used for energy. The American Heart Association recommends approximately 150 minutes of exercise every week for adults. Participating or engaging in exercise on a daily basis can improve high blood sugar levels as well as promote overall health and wellness.
For more information regarding how to naturally improve insulin resistance, please review this article:
Insulin is an essential hormone that is naturally produced in the pancreas to help regulate blood sugar levels and move excess sugar from the bloodstream into the cells to be used for energy. When the pancreas senses high blood sugar levels in the blood, it creates more insulin to help reduce glucose. However, this can decrease the amount of insulin-producing cells in the pancreas which can cause insulin resistance or impaired insulin sensitivity. If the pancreas can’t produce enough insulin, it can ultimately lead to prediabetes or type 2 diabetes, among other health issues. There are several natural ways to improve insulin resistance or impaired insulin sensitivity to prevent and regulate prediabetes and type 2 diabetes, including eating good foods, avoiding bad foods, and exercising. Furthermore, adding a variety of good foods to a smoothie can be a fast and easy way to add nutrients to your diet. – Dr. Alex Jimenez D.C., C.C.S.T. Insights
Sweet and Spicy Juice
Servings: 1 Cook time: 5-10 minutes
1 cup honeydew melons
3 cups spinach, rinsed
3 cups Swiss chard, rinsed
1 bunch cilantro (leaves and stems), rinsed
1-inch knob of ginger, rinsed, peeled, and chopped
2-3 knobs whole turmeric root (optional), rinsed, peeled, and chopped
Juice all ingredients in a high-quality juicer. Best served immediately.
Eat Mushrooms
One simple thing we can do to improve the microbiome!
Mushrooms feed bacteria in the gut. They are rich in chitin, hemicellulose, ? and ?-glucans, mannans, xylans, and galactans. They are also amazing prebiotics that promotes the growth of gut microbiota, equalling health benefits.
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask�Dr. Alex Jimenez�or contact us at�915-850-0900.
Curated by Dr. Alex Jimenez D.C., C.C.S.T.
References:
Raman, Ryan. �14 Natural Ways to Improve Your Insulin Sensitivity.� Healthline, Healthline Media, 17 May 2017, www.healthline.com/nutrition/improve-insulin-sensitivity.
Felman, Adam. �Diet and Insulin Resistance: Foods to Eat and Diet Tips.� Medical News Today, MediLexicon International, 27 Mar. 2019, www.medicalnewstoday.com/articles/316569#foods-to-eat.
Being able to hike with back pain is a blessing for individuals that love being outdoors. Enjoying nature and being able to get away from all the stress and tension is something we all can use. Hiking is an excellent physical activity that cleanses the mind, body, and spirit. Not to mention the great exercise benefits that come with it.
The time spent going up and down hills following trails, etc. can feel unbelievable until pain symptoms start to present. Those with back pain know and understand that there are certain activities that can kick in the pain. If hiking has been stopped in its tracks because of back pain, or, if just about to start hiking for the first time, here is some advice to reduce and alleviate back pain during and after a hiking session. �
Contents
�
Hike The Right Way
Dr. Alex Jimenez D.C. is a spine injury specialist at Injury Medical Chiropractic Clinic. He believes at its core, hiking is very beneficial to individuals with back pain.
Hiking is a great activity for those with back pain because it increases muscular circulation improving soft tissue flexibility in the spine along with other muscle groups. Hiking helps strengthen spinal support muscles, improves flexibility and posture. The result is minimized pain on all levels. Walking on different uneven terrain/s contributes to improved balance and synergistic muscle activity of the back, legs, and core, and the small muscles of the feet. However, there is an incorrect way to hike with back pain.
If done incorrectly hiking can have a negative detrimental impact on the body. Proper technique and form need to be followed. For example, a backpack that is improperly worn or not correctly sized for the body type could lead to imbalance. This could lead to improper form and injuries. Poor posture during a hike places added pressure on the:
Joints
Spine
Ligaments
Tendons
This could easily result in muscle/tendon injuries. With some preparation, a few tips and being aware of your surroundings will help you to become a hiking pro in no time, with reduced, improved, and possibly no back pain after a while of doing this great activity. Here are some words of wisdom when it comes to hiking and back pain.
�
Proper Backpack
A poor-fitting backpack will easily lead to increased back pain and even other ailments like shoulder and neck pain issues. A proper backpack should have the straps around the waist and across the back to evenly distribute the weight. Visit a sports/outdoor store to get correctly fitted for a backpack.
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Stretching Out
Getting and staying loose before and after a hike is very important. Before a hike improves circulation and loosens the muscles, in turn, reducing the stress on the joints. Stretching after a hike reduces muscle fatigue and soreness that can amplify and exacerbate back pain along with any other body soreness.
�
Trekking Poles
Using trekking poles can be beneficial and quite helpful for individuals with back pain. Trekking poles can help avoid poor posture by keeping the body in an upright position. This helps reduce back pain experienced during and after a hike. �
�
Body Care
Hiking successfully means that the body needs to be fully functional and fueled before even stepping on the trail. Fueling the body with nutritious snacks like bananas, dried fruit, and trail mix will keep the body’s energy supply going. And above all stay hydrated with plenty of water. Also, focus the workout on developing upper body and core strength to prevent injury.
Don’t forget to listen to what your body is telling you. Individuals with back pain need to listen to their bodies making sure not to overdo it, as well as, with any type of exercise, to adjust to your specific pain tolerance level. If unable to limit distance or time, then make sure to take frequent breaks. This will help avoid placing unnecessary strain on the spine. �
�
Recovery Time
The body needs a proper amount of time between hikes to recover properly. If there is still soreness and pain, WAIT until the body is no longer sorebefore trekking to the next trail. The amount a person can hike depends on the individual, overall strength, and how fast their body recovers between hikes. It is different for everyone.
�
Assistance
As the journey commences, whether going for pain-free or less painful hiking, remember that it’s ok to have others help get you there. Getting help from a veteran hiker will definitely benefit proper form and posture. Hiking with an experienced partner can also help avoid poor hiking techniques that can worsen back pain or even create new injuries. �
�
Consult a local chiropractor, or spine, and pain specialist if you are unsure about hiking and are experiencing ongoing back pain. They will help develop a customized/personalized treatment plan with the focus on decreasing and controlling the pain and improving the body’s overall function to be able to participate in physical recreational activities.
Researchers are trying to understand how nutrigenomics can affect a person’s health. Studies have shown that epigenetics increases the risk of several health issues. Other studies have also shown that nutrition can change the risk of disease. For many years, researchers have studied the way that traits in plants and animals are passed down between generations. However, this process is still not well understood. A recent study evaluated how epigenetic marks are passed down between generations of pregnant rats given personalized nutrition. The findings showed both genetic and characteristics changes in the rats’ offspring. This suggests that maternal traits and diet may send different signals to the fetus.
Another study showed methylation changes in mice given more methyl donor intakes over six generations. These findings demonstrated that genetic and characteristic changes passed down between generations may be how environmental factors affect genes in plants and animals to allow adaptation to different environments.�The purpose of the following article is to discuss how nutrigenomics and traits between generations can ultimately affect a person’s overall well-being.
Contents
Epigenetics, Nutrition, and Exercise
Researchers have determined that the role of epigenetics in health issues like cancer is caused by methylation changes in several different types of genes and it is commonly associated with aging. However, the increased risk of cancer may be due to factors in the person’s immediate course of life where changes in epigenetics may happen years before the development of health issues like cancer. One study found that methylation of the breast-cancer-related gene is associated with the increased risk of early-onset breast cancer. Other studies have shown that resveratrol prevents methylation changes while folic acid affected gene expression associated with changes in methylation and other functions.
Eicosapentaenoic acid also caused methylation changes in the tumor suppressor gene associated with leukemia cells. This study demonstrated the effect of a polyunsaturated fatty acid on epigenetics. Another study found that methylation increased in women diagnosed with human papillomavirus that didn’t have cervical intraepithelial neoplasia. The changes in methylation were associated with higher concentrations of folate and cobalamin in the blood stream. Another study also found that methylation changes in the tumor suppressor gene L3MBTL1 were ultimately associated with overall health. Further studies are necessary to determine how nutrition can affect epigenetics and traits between generations.
Two studies evaluated the effects of exercise on methylation. One of the studies showed methylation changes in people who participated in physical activities for about 30 minutes every day compared with people who engaged in physical activities for less than 10 minutes every day. In the other study, volunteers who participated in exercise demonstrated changes in methylation and gene expression. These findings suggest that methylation is affected by physical activity.
Nutrigenomics and Risk of Health Issues
Numerous studies have evaluated the role of epigenetics in people with diabetes. According to researchers, changes in methylation of several genes have been shown to be associated with insulin resistance in patients with diabetes. A single change in gene expression caused significant methylation changes in people with diabetes compared to healthy controls. However, other studies found changes in traits between generations and obesity. Furthermore, methylation changes did happen in people with normal glucose metabolism which then developed impaired glucose homeostasis. Various genes have been shown to be different in people with diabetes compared to healthy controls, according to the studies.
According to numerous other studies, twins were found to have increased methylation associated with increased insulin resistance. These findings suggest that epigenetic marks associated with diabetes may occur before symptoms and determine the risk of disease. In conclusion, increasing evidence has demonstrated that nutrition can ultimately cause changes to a person’s epigenetics and how these are associated with the increased risk of developing health issues.
Healthcare professionals and researchers have demonstrated that we can change our epigenetics and gene expression as well as improve the risk of developing a variety of health issues, including inflammation and cancer, which can ultimately cause chronic pain, by controlling the food we eat and focusing on our nutrigenomics. Starting in the kitchen and then taking it directly to the genes, if we follow balanced nutrition, we will see a significant change in our overall health and well-being. At our clinic, we have the ability to assess your specific genetic factors and what dietary guidelines are best for you. One test we use for this is from DNA life, called DNA Diet. A sample of this report is shown below:�
Studies show that nutrition can affect methylation and gene expression. These studies have also found that balanced nutrition can improve how good food affects our overall health and well-being. The following article discussed how our epigenetics can affect traits passed down between generations, including methylation and the risk of disease. Although a good diet is essential it may be difficult for some people to follow. Drinking juices or smoothies can be easy ways to include the balanced nutrition we need to promote our health and well-being. Below, I’ve provided a smoothie recipe so you can address your nutrigenomics from the kitchen to your genes. – Dr. Alex Jimenez D.C., C.C.S.T. Insights
Berry Bliss Smoothie
Servings: 1Cook time: 5-10 minutes
1/2 cup blueberries (fresh or frozen, preferably wild)
1 medium carrot, roughly chopped
1 tablespoon ground flaxseed or chia seed
1 tablespoons almonds
Water (to desired consistency)
Ice cubes (optional, may omit if using frozen blueberries)Blend all ingredients in a high-speed blender until smooth and creamy. Best served immediately.
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask�Dr. Alex Jimenez�or contact us at�915-850-0900.
Curated by Dr. Alex Jimenez D.C., C.C.S.T.
References:
KA;, Burdge GC;Hoile SP;Lillycrop. �Epigenetics: Are There Implications for Personalised Nutrition?� Current Opinion in Clinical Nutrition and Metabolic Care, U.S. National Library of Medicine, 15 Sept. 2012, pubmed.ncbi.nlm.nih.gov/22878237/.
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Getting back to the house and eating a regular meal post a spinal operation is one of those moments when more is better. This means more:
Calories
Protein
Healthy foods to help the body recover quicker
The time after neck or back surgery is not only a time for the spine to heal, but for the entire body to go through a recovery process. It is a generally slow progression, but once you are able to eat normally, a high-quality diet/meal plan will help ensure a smooth and speedy recovery. �
The first few days after arriving home there could be nausea, which is common coming out of anesthesia and beginning pain medication. Appetite could be diminished, which is just fine because the gastrointestinal tract needs time to get back functioning properly after spine surgery.
A positive sign that the digestive system is beginning to work properly is the ability to pass gas. Recovery in a hospital, the surgical team slowly transitions from a clear liquid diet to a soft diet and finally to solid food.
Once out of the hospital, the body should be ready to eat normally. Your surgical team will discuss and provide the individual with a specific meal plan, but a general approach to a post-spine surgery diet typically follow these parameters:
Contents
�
More Calories
Post spine surgery, the body’s metabolism increases in order to heal. So the body needs extra calories, around twice as much for proper recovery. It is very important that these extra calories are from healthy foods like:
Grains
Legumes
Fruits
Vegetables
� These will provide the body with extra vitamin C and other nutrients that the body needs for healing a wound and the recovery process that goes with it.
�
High-Protein
Protein is the key nutrient required for post-surgery healing and recovery. Extra calories should come from:
� Low-fat dairy is a good source of protein that provides calcium and vitamin D for bone restoration. High-protein foods are often high in zinc, which is essential in fighting infections.
Eat More Small Meals
Rather than eating three regular-sized meals, try to eat four to six small, well-balanced meals. These should be spaced throughout the day into the evening. These will be easier on the digestive system, especially when increasing the calorie intake.
Supplement Shakes or Smoothies
Smoothies and shakes are a great way to boost calories and protein post-op. Make them with milk, soymilk, yogurt, or other high-protein food or beverage as the base. There are also prepared shakes or smoothies at the supermarket or drug store that are specifically prepared to boost calories and protein. �
�
Vitamins and Minerals
The surgeon will more than likely recommend vitamin and mineral supplements, along with other dietary supplements to promote healing. Be sure to get a doctor�s approval before taking any other supplements during recovery. �
�
Water and Fiber
Pain medication can cause constipation. The most important thing to do is to drink plenty of water throughout the day. This is vital to the healing process. Eat plenty of high-fiber foods like whole grains, fruits, and vegetables. There is also a natural laxative effect from drinking prune juice or eating prunes, which are dried plums. �
�
If there is any trouble following the post-op diet plan or any questions about food or supplements, contact the surgeon, dietitian, or a health coach/nutritionist. At a follow-up appointment, ask how long the special diet will have to last so you can plan accordingly.
Healthcare professionals commonly give nutritional recommendations based on an entire population, only sometimes changing these according to age, sex, and pregnancy. Over the last 20 years, however, an increase in research studies has demonstrated that epigenetics can ultimately affect nutrition and even increase the risk of developing a variety of health issues, including oxidative stress and inflammation. Recent advances in technology are also currently being used to help healthcare professionals understand how nutrigenomics can affect an individual’s overall health and wellness.
Several research studies have also demonstrated that single nucleotide polymorphisms can explain the risk for individual complex disease traits. A single-nucleotide polymorphism, or SNP, is a substitution of a nucleotide that happens in the genome. Moreover, further research studies can be utilized to explain the variation in health issue risk based on nutrition and genome. The purpose of the following article is to discuss recent developments in the field of epigenetics and personalized nutrition as well as to consider the contribution of research studies to nutritional recommendations.
Contents
Understanding Nutrigenomics
Epigenetics is a collection of changes that affect chromatin structure, without altering our DNA sequence, while allowing transcriptional regulation over a range of timescales. Common epigenetic processes include histone modification, non-coding RNAs, and DNA methylation. Many research studies on how epigenetics affects personalized nutrition focus on DNA methylation, however, research findings have demonstrated other epigenetic marks. DNA methylation inside a dinucleotide is a well-known modification in the genome of a variety of mammals in DNA replication and cell division.
Methylation of dinucleotides is shown by DNA methyltransferases, or Dnmts, and is regulated by mitosis. DNA methylation can trigger transcriptional silencing by blocking and/or promoting the connection of transcription factors in the methyl CpG-binding protein MeCP2 which activates histone-modifying complexes to the DNA. MeCP2 activates what is frequently referred to as histone deacetylases, or HDACs, and histone methyltransferases, or HMTs, resulting in a closed chromatin structure and transcriptional silencing. These have been demonstrated to be associated with various health issues.
Dnmt1 is activated by HDACs and HMTs which suggests that chromatin structure may also affect the status of DNA methylation in the regulation of genes associated with nutrition. According to healthcare professionals, epigenetic marks are essentially maintained throughout an individual’s life. However, recent research findings show that epigenetic plasticity can be affected in early development, including in stages of increased physiological changes, such as puberty and aging. This ultimately suggests the possibility that epigenotypes associated with the increased risk of developing health issues can change.
Epigenetics, Personalized Nutrition, and Origins of Health Issues
Research studies have demonstrated that our early life environment can affect our epigenetic process and the origins of health issues. Healthcare professionals also believe that nutrition in our early life can affect our epigeno- and phenotype in the future. Pregnant rat groups given a diet with corn oil resulted in hypermethylation and decreased gene expression in the offspring, causing mature osteoblasts. This is the first research study to find how maternal diet affects epigenetic processes by altering morphogenesis and changing non-imprinted gene expression in pregnant rat groups.
Pregnant rat groups given a diet with an undisclosed type of fat had increased fetal blood glucose concentration and increased mRNA expression of gluconeogenic genes in the fetal liver. A recent research study found that the amount of fat in the maternal diet was one of the major factors resulting in epigenetic changes in the offspring of pregnant rat groups. The diets given to the pregnant rat groups including fat derived from safflower oil, butter, hydrogenated soybean oil, or fish oil caused hypermethylation in the offspring compared with those where pregnant rat groups were only given 7 percent fat.
Furthermore, one research study found that pregnant rat groups given a protein-restricted, or PR, diet developed epigenetic silencing in both histone modifications and DNA methylation which was followed by progressive transcriptional suppression as the offspring aged. The research findings suggest that nutrition during early development can ultimately cause long-term changes in phenotype. Pregnant rat groups given a PR diet also developed hypomethylation of specific dinucleotides in the adipose tissue leptin promoter and in the heart PPARa promoter in adult offspring.
For more information regarding how epigenetics affects personalized nutrition, please review this article:Epigenetics: Are There Implications for Personalised Nutrition?
Healthcare professionals have demonstrated that we can change gene expression and improve the risk of developing a variety of health issues, including oxidative stress and inflammation which can cause chronic pain, by controlling the food we eat. Starting in the kitchen and then taking it to the genes, if we follow a balanced nutrition, we will see a considerable change in our overall health and wellness. We have the ability to assess your specific genetic factors and what dietary guidelines are best for you to follow. One test we use is from DNA life called DNA Diet. A sample of this report is shown below:�DNA-Diet-Sample-Report-2019.pdf
Research studies have demonstrated how epigenetics affect personalized nutrition. The same research studies have also demonstrated that a balanced nutrition can change our gene expression to improve how good food affects our overall health and wellness. While following a proper diet can help improve the risk of developing a variety of health issues, including oxidative stress and inflammation associated with chronic pain, eating good food may be difficult for some people. That’s why drinking smoothies or juices can be easy ways to include the balanced nutrition we need to promote our well-being. In the section below, I’ve provided a smoothie recipe so you can take your health and wellness from the kitchen to your genes. – Dr. Alex Jimenez D.C., C.C.S.T. Insights
Sea Green Smoothie
Servings: 1Cook time: 5-10 minutes
� 1/2 cup cantaloupe, cubed
� 1/2 banana
� 1 handful of kale or spinach
� 1 handful of Swiss chard
� 1/4 avocado
� 2 teaspoons spirulina powder
� 1 cup water
� 3 or more ice cubes
Blend all ingredients in a high-speed blender until completely smooth and enjoy!
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask�Dr. Alex Jimenez�or contact us at�915-850-0900.
Curated by Dr. Alex Jimenez D.C., C.C.S.T.
References:
KA;, Burdge GC;Hoile SP;Lillycrop. �Epigenetics: Are There Implications for Personalised Nutrition?� Current Opinion in Clinical Nutrition and Metabolic Care, U.S. National Library of Medicine, 15 Sept. 2012, pubmed.ncbi.nlm.nih.gov/22878237/.
Chiropractor, Dr. Alex Jimenez shares some how-to advice on taking hot baths for back tension and pain. A bath can be a wonderful and fulfilling experience in self-care for back pain. There are medical benefits from taking a hot bath, as well. A hot bath can be extremely helpful when it comes to back pain.
Dr. Jimenez helps his patients with spinal ailments and conditions that range from arthritis, degenerative disc disease to nerve compression, sciatica, auto accident injuries, sports injuries, etc. In addition to chiropractic, physical therapy, diet, and exercise, he has also seen the power of home remedies, like a hot bath.
There are scientific studies that have shown how hydrotherapy can relieve back pain. Dr. Jimenez describes a hot bath as a muscle-relaxing stimulus. It opens up the muscles, which allows more blood to flow through, which in turn helps to heal injury/s, tightness, and soreness. It helps to clean out lactic acid, which is known to cause muscle pain, fatigue, and muscle cramps.
Here is what usually happens to the spine when soreness, tightness, aching, and pain present. A spinal structure like a nerve, disc, vertebral bone, or other tissue is injured or on the verge of injury, and the muscles around it contract closely in to prevent more damage.
This is called muscle spasm. Don’t worry the body is supposed to respond this way, as it means the damaged tissue is less likely to sustain further injury. However, muscle spasms can be painful. Much like a Charley horse, a back spasm can have the same effect.
For example, someone standing or working for an extended period places the muscle/s under constant tension, which means they have a higher chance of having a spasm and developing painful symptoms. A hot bath relaxes the muscle/s and reduces/removes the aching soreness and pain. Here are some tips to help relax the back muscles. �
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Try Epsom Salt
Taking a bath with Epsom salt or minerals that dissolve in water can be helpful, but are not necessary. Many are fantastic skin relaxants, but if you have a hot bath with or without the salt, it�s not going to make a huge difference. What makes the bath work is the heat and the floatation. This what creates the benefits.
Soak 15-20 Minutes
It is really up to the individual, as to how long they want to stay in the tub. One question to ask is how long can you take sitting in hot water? Hot tubs are normally heated to about 102 to 103 degrees. With these types of tubs, individuals can sit for a half-hour or more. However, most of us do not have a jacuzzi, so remember that a regular bath will be warmer possibly 105 or 106 degrees. It all depends on how long you can take the heat. �
� Remember not to scald yourself with a bath that is way too hot to soak in, please. It�s ok to get the water running hot, but as it fills turn the heat down and let it cool slightly before stepping in. Most individuals don�t need more than 15 to 20 minutes of soaking time maximum.
As for how often one should take a hot bath, Dr. Jimenez explains that it depends on the severity of the back pain and what type of work and activities the individual does. For most three times a week offers a balanced therapy. If an individual has a strenuous physical job like construction work, manual lifting, standing work, or doing highly repetitive work then they�ll need to do more than 3 times a week.
Strengthen the Body’s Core
A strong core can support and protect the spine, along with the rest of the body. Squeezing and contracting the back, side, and front muscles make the core strong and robust. It behaves like a steel beam supporting the spine when added protection is needed.
Stretch Out
After a hot bath is a perfect time to stretch. Toe touches can loosen tight hamstrings that can strain the lower back. Also, try out yoga’s upward-facing dog pose. Sun salutationscan help the spine go through a wide range of motion. Therefore do them slowly and hold each pose for a few breaths. A long salutation or two can feel tremendous when the spine is nice and relaxed.
Take Care When Getting Out
Hot baths might not be a good idea or the right option for certain people. If there is instability in your spine and the vertebra move around more than they are supposed to then a hot bath might not be the best option. Instead, a hot shower with a massage setting could be equivalent to taking a hot bath.
However, if a hot bath is not helping with back pain it could be a sign of something more than muscle tightness or a muscle spasm. A spine specialist or chiropractor can give you a proper diagnosis.
Minimally invasive spine surgery known as M.I.S.S is an option to traditional open surgical procedures, as well as an alternative when non-surgical approaches are working but the pain or condition is becoming worse, regardless. These are performed to treat a variety of spinal disorders like:
Bone spurs
Degenerative disc disease
Herniated disc
Scoliosis
Spinal instability
Spinal stenosis
Spinal tumors
Minimally invasive surgery can offer potential benefits. These include
A small/tiny incision/s
Minimal cutting through soft tissues like ligaments, and muscles
Outpatient option/s
Reduced post-operative pain
Quicker recovery
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The Focus of Spine Surgery
There are two main goals when it comes to spine surgery or rather the goal/focus of the surgery. These are decompressing and stabilizing the spine.
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Decompression of the spine
Spinal decompression involves removing any tissue/s that are compressing/pinching the nerve structures like a spinal nerve root or the spinal cord itself. Bone spurs and fragments from a herniated disc are the types of tissue/s that can cause neural compression.
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Stabilization of the spine
An abnormal movement of one or more levels/segments of the spinal cord can cause back pain, neck pain, or both. Surgeries that are meant to stabilize and stop these abnormal movements utilize spine instrumentation combined with fusion.
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Spine Surgery Techniques
Minimally invasive spine surgery techniques include:
Rather than cutting through soft tissues, a tubular retraction instrument generates a tunnel that expands and passes between the muscle/s to access the spine’s column. Then an endoscope or a tiny video camera goes in and around the area, projecting a visualization of what’s happening on a monitor during the procedure.
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This is the surgeon’s/team’s eyes as they work to repair the damage. The surgery is run through the tubular retraction system along with any specially designed instruments that are needed. Types of surgical procedures performed with minimally invasive surgery include:
Discectomy
Microdiscectomy
Foraminotomy
Microforaminotomy
Microlaminectomy
Microlaminotomy
The micro means that the surgery is done using a special microscopic camera to view the disc/s and nerve/s. Imaging scans, systems, and image-guidance technologies, like fluoroscopy, which is a real-time x-ray are utilized during the surgery pinpointing the key aspects of the patient�s spinal anatomy. The surgical imaging shows 2D and 3D views, which guides the placement of any instrumentation, like pedicle screws.
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Disorders Treated with Minimally Invasive Surgery
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Degenerative disc disease
Degenerative disc disease is known as DDD often develops progressively in older adults and affects the intervertebral discs. The normal wear and tear of cellular age-related changes in the body can cause the spine’s discs to:
Stiffen
Lose Flexibility
Loss of Strength
Loss of Height
Lose shape, along with the ability to absorb/distribute the forces associated with moving
These structural changes increase the risk of disc herniation and subluxations.
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Herniated discs
A herniated disc also called a slipped, bulging, and ruptured disc. This happens when the soft gel cushion of a disc breaks through the protective outer layer. Other than the damaged disc, the loose interior gel can also irritate and inflame the nerves causing back pain. �
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Scoliosis
Scoliosis is an abnormal sideways curve of the spine that can cause progressive spinal deformity. A scoliotic curve can look like an �S� or �C.� Most cases have no known cause, and while the condition is more commonly associated with children, adults can develop scoliosis, as well.
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Spinal stenosis
Spinal stenosis happens when the spinal nerve roots and the spinal cord become compressed/pinched. These nerves branch off the spinal cord and exit the spinal canal through passageways called neuroforamen. Nerve and spinal cord compression can cause symptoms like:
Pain
Weakness
Tingling sensations
Numbness
Sometimes, pain can travel into the arms or legs
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Spine Surgery Risks
With any spine surgery there are potential risks and complications that can occur. Here are some possible complications that can happen during and after surgery, with both open and minimally invasive procedures.
Minimally invasive spine surgery does offer many benefits:
Tiny incision
Less pain
Reduced risk
Faster recovery
Let’s not forget that M.I.S.S is still surgery. Less than 5% of people with back or neck pain need spine surgery and, surgery is the last resort for treating pain and symptoms caused by a spinal condition/disorder.
It is only when non-surgical treatments like chiropractic, acupuncture, physical therapy, medication, or spinal injections do not reduce symptoms in 3 to 6 months. This is when you qualify to be a candidate for spine surgery. There are certain types of spinal disorders that require urgent or immediate surgical intervention.
Talk with your doctor, chiropractor, or spine specialist about the pain, the symptoms, and compare the results of the different therapies/treatments and go from there. With any type of surgery there are many considerations to discuss before making a decision to treat back or neck pain and if minimally invasive surgery could be an option.
Seven: Working in the yard, and wherever else the sun beats down relentlessly will be a test as to the type of shape your body is in. Poor eating habits have increased fat deposits, as well as sitting around. Never fear, it is recommended that you try out these seven exercise tuneup tips to get back in shape as summer begins.
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Seven
Drink proper amount of water regularly
Water helps immensely in generating fat-loss. 64 ounces a day is the absolute minimum. Twice that amount, or one-gallon, is the way to go, making sure the water is ice cold. Ice water is about 40-degrees Fahrenheit. This means the body’s system has to heat the water to a core body temperature of 98.6 degrees.
The process requires about one calorie to warm one ounce of cold water to body temperature. Therefore an 8-ounce bottle of ice waterburns seven calories. Try that with 16 glasses, which equals 128 ounces, or one gallon. This generates 123 calories of heat energy. �
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Eat small meals more often
Fat-loss study subjects were given six meals to consume a day, with no meal having more than 400 calories. The study emerged successfully. It is important to allow no longer than three hours between eating. This could be snacks, light meals, salads, etc.
Eating with this type of pattern keeps the body on an even keel. And since the individual is never overly-full/stuffed and never over-hungry/famished this seems to be ideal for losing weight and getting rid of fat cells. �
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When eating takeout Assert Yourself
All the help you can get to avoid gorging on rich, high-caloric, restaurant foods. Here are some tips:
Don’t go through the whole menu
Choose a simple green salad without the garnish
Lemon juice, vinegar, or low-calorie dressing is the way to go instead of the creamy and oily dressings.
Select one or two vegetables with nothing
A plain baked potato is a great choice
Other positive choices are broccoli, carrots, and cauliflower
Find out what kind of fish is available
Try the fish baked, steamed, or broiled, with nothing on top
Decaffeinated coffee or tea as a dessert, with some fresh fruit
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Get an exercise routine that you will stick to
Be careful if it’s swimming or some type of water-based exercise. Swimming does offer benefits, but the thermal effect of being in the water can cause you to eat more from all of the energy loss. Strength training is the way to go, so you can lose weight and then get into the water exercises. More than any other exercise or activity strength training promotes a double-reducing advantage. �
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Do not Over-Exercise
Overdoing it with the exercise can tear down body tissue/s, increasing the risk of injuries, which then puts you in downtime and less active.
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Too much Television Time
Decrease the exposure to television because of the convenient foods that are offered. This diminishes the temptation to overeat. Get involved in a household project, along with the extended daylight hours, can help this situation.
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Take advice
When you are tough on yourself, life can become a beautiful thing, as you witness the benefits from the hard work. We don’t pay the price for good health, we just enjoy it along with the benefits. However, we do pay the price for bad/poor health. �
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Exercise Facts
More than half of adults do not get the recommended amount of exercise.
Try for at least 20 minutes of exercise a day.
Around 25% of adults don’t exercise at all
Keep the exercise routine fresh by mix it up doing different activities like alternate power walking, yoga, bicycling, tennis, band workouts, etc.
Regular exercise helps maintain healthy bones and helps keep the muscles and joints strong.
Incorporate fitness into a daily routine to help control weight and boosts mood and sense of well-being.
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