Back Clinic Health Team. The level of functional and metabolic efficiency of a living organism. In humans, it is the ability of individuals or communities to adapt and self-manage when facing physical, mental, psychological, and social changes in an environment. Dr.Alex Jimenez D.C., C.C.S.T, a clinical pain doctor who uses cutting-edge therapies and rehabilitation procedures focused on total health, strength training, and complete conditioning. We take a global functional fitness treatment approach to regain complete functional health.
Dr. Jimenez presents articles both from his own experience and from a variety of sources that pertain to a healthy lifestyle or general health issues. I have spent over 30+ years researching and testing methods with thousands of patients and understand what truly works. We strive to create fitness and better the body through researched methods and total health programs.
These programs and methods are natural and use the body’s own ability to achieve improvement goals, rather than introducing harmful chemicals, controversial hormone replacement, surgery, or addictive drugs. As a result, individuals live a fulfilled life with more energy, a positive attitude, better sleep, less pain, proper body weight, and education on maintaining this way of life.
Our brain is a complex organ that controls many essential functions in our body. Therefore, brain health is vital for our survival. This is where the blood-brain barrier comes in. The blood-brain barrier (BBB) consists of a group of cells held together by “tight junctions” that protect the brain from potentially harmful components in the bloodstream. This security system only permits passage to certain molecules and keeps most other chemicals or substances out. �
Understanding a Leaky Brain
If damage due to an injury or underlying condition occurs, small gaps can start to develop in the tight junctions of the group of cells in the brain and potentially harmful components in the bloodstream can ultimately penetrate the BBB and enter the complex organ. This is known as a “leaky brain”. Several chemicals or substances can commonly cause brain inflammation. Research studies have demonstrated a connection between gut health and brain health. As a matter of fact, scientists have also determined that our gut microbiome, or the bacteria in our gastrointestinal (GI) tract, can affect our brain. �
The stomach and small intestine consist of a group of cells like the blood-brain barrier that also protects the gut from potentially harmful components in the gastrointestinal (GI) tract. Similar factors that cause a leaky gut can cause a leaky brain, including poor diet, food sensitivities or intolerances, infections, and toxins. Research studies have demonstrated that a protein found in wheat and gluten, known as gliadin, can increase the production of another protein known as zonulin. Zonulin can cause the tight junctions of the gut and BBB to become loose or broken, leading to a leaky brain and a leaky gut. �
Diagnosis of a Leaky Brain
If you suspect that you may have a leaky brain following common causes and symptoms associated with the breakdown of the blood-brain barrier, make sure you talk to a qualified and experienced healthcare professional to receive a proper diagnosis and follow up with treatment. Healthcare professionals can receive a variety of screening tests in order to be able to find out their overall risk of a leaky brain. These can include one or more of the following tests: �
Occludin and Zonulin
The proteins known as occludin and zonulin can help determine both gut and blood-brain barrier permeability in a leaky gut and a leaky brain. According to research studies, increased levels of antibodies combating against occludin and zonulin proteins are another common way to diagnose a leaky brain. �
Genetic Testing
A leaky brain can also be diagnosed using genetic testing. Changes in any of the genes that regulate the cells of tight junctions in the brain, oxidative stress, inflammation, or immune response can cause a leaky brain. Diagnosis of these genes can even further help determine treatment for a leaky brain. �
GABA-EEG
Gamma-aminobutyric acid (GABA) is a neurotransmitter that helps control signals in the brain. Recent research studies have demonstrated that GABA can penetrate the BBB and enter the brain. A GABA-EEG can help determine how much gamma-aminobutyric acid passes the BBB to cause a leaky brain. �
MMP9 Level Evaluation
Matrix metalloproteinases, also known as MMPs, are enzymes that break down the peptide bonds that hold proteins together. These, however, can ultimately cause the cells of the tight junctions in the brain to become lose and broken, breaking down the BBB. MMPs can also increase after damage, injury, or an underlying condition in the liver or brain, such as a stroke or a traumatic brain injury. Testing for increased MMPs in the bloodstream can help diagnose a patient’s risk of developing a leaky brain. As an initial treatment, several patients can start taking an MMP inhibitor to decrease BBB permeability.
Spectrophotometry and Optical Imaging
The protein known as albumin flows in the bloodstream, however, it can’t penetrate the BBB or enter the brain under healthy conditions. To diagnose a leaky brain using spectrophotometry and optical imaging, healthcare professions may inject albumin with a dye called Evans Blue which only binds and dyes the protein in the bloodstream. Spectrophotometry and optical imaging can demonstrate the amount of Evans Blue dye that has accumulated in the brain. �
Treatment of a Leaky Brain
According to many healthcare professionals, treating a leaky brain ultimately starts by treating a leaky gut. Reducing and/or eliminating all of the factors that cause a leaky gut and a leaky brain as well as including diet and lifestyle modifications can help promote overall gut and brain health. The following steps can help treat a leaky brain by decreasing inflammation in the brain and the body, increasing oxygen, glucose, and other nutrients in the brain, improving the removal of harmful components in the brain, reducing oxidative stress, and restoring the BBB by ultimately repairing cells in the tight junctions of the brain. �
Treat bacterial and viral infections
Detox from heavy metals and pesticides
Prevent exposure to environmental toxins in the air, water, and food
Reduce or eliminate food sensitivities and intolerances
Avoid sugar and processed foods
Reduce inflammation through diet
Eat essential fatty acids, including avocado, coconut oil, flaxseed, hemp seed, oily fish, pumpkin seeds, and walnuts
Take probiotics to help maintain a healthy gut
Seek supplements that help repair the BBB
Stop drinking excess alcohol
Exercise and practice yoga or mindful meditation
Manage stress
Get good rest and quality sleep
Too much inflammation may cause a variety of brain health issues and neurological diseases associated with the breakdown of the blood-brain barrier (BBB), also known as a leaky brain. Because many research studies have suggested the connection between a leaky gut and a leaky brain, maintaining a healthy gut microbiome may be an effective treatment for brain health issues and neurological diseases. Scientists have started working towards developing successful ways to allow drugs and/or medications as well as other treatments to penetrate and enter the brain through the blood-brain barrier and from the bloodstream. A leaky brain may be caused by a variety of factors and various symptoms can commonly manifest.� – Dr. Alex Jimenez D.C., C.C.S.T. Insight
Our brain is a complex organ that controls many essential functions in our body. Therefore, brain health is vital for our survival. This is where the blood-brain barrier comes in. The blood-brain barrier (BBB) consists of a group of cells held together by “tight junctions” that protect the brain from potentially harmful components in the bloodstream. This security system only permits passage to certain molecules and keeps most other chemicals or substances out. �
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.�
Curated by Dr. Alex Jimenez �
References:
Mindd Foundation. �What Causes Leaky Brain? Repairing the Blood-Brain Barrier.� Mindd, 11 June 2019, mindd.org/leaky-brain/.
Neurotransmitter Assessment Form
The following Neurotransmitter Assessment Form can be filled out and presented to Dr. Alex Jimenez. The following symptoms listed on this form are not intended to be utilized as a diagnosis of any type of disease, condition, or any other type of health issue. �
Additional Topic Discussion: Chronic Pain
Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals, however, chronic pain is different than the average type of pain. With chronic pain, the human body will continue sending pain signals to the brain, regardless if the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient’s mobility and it can reduce flexibility, strength, and endurance. �
Neural Zoomer Plus for Neurological Disease
�
Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual�s reactivity to 48 neurological antigens with connections to a variety of neurologically related diseases. The Vibrant Neural ZoomerTM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention. �
Food Sensitivity for the IgG & IgA Immune Response
�
Dr. Alex Jimenez utilizes a series of tests to help evaluate health issues associated with food sensitivities. The Food Sensitivity ZoomerTM is an array of 180 commonly consumed food antigens that offers very specific antibody-to-antigen recognition. This panel measures an individual�s IgG and IgA sensitivity to food antigens. Being able to test IgA antibodies provides additional information to foods that may be causing mucosal damage. Additionally, this test is ideal for patients who might be suffering from delayed reactions to certain foods. Utilizing an antibody-based food sensitivity test can help prioritize the necessary foods to eliminate and create a customized diet plan around the patient�s specific needs. �
Gut Zoomer for Small Intestinal Bacterial Overgrowth (SIBO)
�
Dr. Alex Jimenez utilizes a series of tests to help evaluate gut health associated with small intestinal bacterial overgrowth (SIBO). The Vibrant Gut ZoomerTM offers a report that includes dietary recommendations and other natural supplementation like prebiotics, probiotics, and polyphenols. The gut microbiome is mainly found in the large intestine and it has more than 1000 species of bacteria that play a fundamental role in the human body, from shaping the immune system and affecting the metabolism of nutrients to strengthening the intestinal mucosal barrier (gut-barrier). It is essential to understand how the number of bacteria that symbiotically live in the human gastrointestinal (GI) tract influences gut health because imbalances in the gut microbiome may ultimately lead to gastrointestinal (GI) tract symptoms, skin conditions, autoimmune disorders, immune system imbalances, and multiple inflammatory disorders. �
Formulas for Methylation Support
XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly,�Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic�Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
�
For your convenience and review of the XYMOGEN products please review the following link. *XYMOGEN-Catalog-Download �
* All of the above XYMOGEN policies remain strictly in force. �
Functional medicine is about taking the human body and treating it as a whole. The human body has many systems but they all work together to maintain homeostasis. In many cases with traditional medicine, a patient with headaches, joint pain, inflammation, and fatigue will be referred to many specialists to treat each individual symptom.� However, by looking at the entire body as a whole and digging into the root cause of the issue and not just the symptom itself, a lot can be revealed.
With functional medicine, often times a series of labs are run that look deeper than the typical basic blood panel. In traditional medicine, a glucose and AHb1c test will be done to assess diabetes. In functional medicine, a deeper test is ordered to rule out other possibilities and practitioners are able to view all components of diabetes including , Adiponectin, Insulin.� This allows a deeper understanding of what is happening inside the body and how to best treat it.�
With this being said, there are many labs that functional and integrative medicine practitioners utilize, each specializing in their own unique panels. The average integrative practice uses an average of 5-10 different lab companies for their patients to have the best care. Eight of the most utilized lab companies are:
Diagnostic Solutions offer many tests but their specialty lies within their GI Map. This test measures the gastrointestinal microbiota DNA from a stool sample. This allows practitioners to see and detect the exact microbes that may be causing a disturbance in the gut or a factor contributing to illness.
Vibrant Wellness has a wide variety of tests but one of the most frequently used is the food sensitivity panel. This allows practitioners to see what foods their patients are consuming that are creating havoc for their gut health.
SpectraCellstarted as a nutritional testing company but has since evolved into a lab that tests cellular nutrition, cardiometabolic health, hormone balances, and genetic predisposition.
Precision Analytical (the D.U.T.C.H test) the D.U.T.C.H test stands for Dried Urine Test for Comprehensive Hormones and takes a look at adrenal and hormone imbalances.
Genova Diagnostics has a wide variety of tests but one of the most common is the GI Effects Comprehensive Profile. This test takes a patient’s stool and detects an organism’s DNA as part of a comprehensive assessment.
Doctors Data provides a wide array of functional testing to provide patients with the best outcomes. Some tests include Environmental Exposure and Detoxification, Toxic and Essential Elements, and Allergy and Immunity.
Cyrex categories their tests as “arrays”. These arrays test for things like diabetes autoimmune reactivity,� The blood-brain barrier, Mucosal Immune Reactivity and more.
Dunwoody Labs offers food sensitivity testing, adrenal, neurotransmitters and many more. Dunwoody can test for specific IgE and IgG4 molecules.
The patient’s health comes first, and getting down to the underlying issues sometimes requires one than one lab company. These companies use the top of the line technology to ensure their patients and physicians obtain the most accurate results for optimal healing.
It is important to make sure the patient gets the best possible care available. This usually means ordering different labs from different companies to obtain the best results. Each lab is great in its own way, but they often specialize in a certain area. This is key because it often allows the patient and the practitioner to get the highest quality of results. A practitioner who uses multiple labs is educated on the subject and truly cares for their patients. – Kenna Vaughn, Senior Health Coach�
*The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request.�
Our brain is a complex organ that controls many essential functions in our body. Therefore, brain health is vital for our survival. This is where the blood-brain barrier comes in. The blood-brain barrier (BBB) consists of a group of cells held together by “tight junctions” that protect the brain from potentially harmful components in the bloodstream. This security system only permits passage to certain molecules and keeps most other chemicals or substances out.
Understanding a Leaky Brain
If damage due to an injury or underlying condition occurs, small gaps can start to develop in the tight junctions of the group of cells in the brain and potentially harmful components in the bloodstream can ultimately penetrate the BBB and enter the complex organ. This is known as a “leaky brain”. Several chemicals or substances can commonly cause brain inflammation. Research studies have demonstrated a connection between gut health and brain health. As a matter of fact, scientists have also determined that our gut microbiome, or the bacteria in our gastrointestinal (GI) tract, can affect our brain. �
The stomach and small intestine consist of a group of cells like the blood-brain barrier that also protects the gut from potentially harmful components in the gastrointestinal (GI) tract. Similar factors that cause a leaky gut can cause a leaky brain, including poor diet, food sensitivities or intolerances, infections, and toxins. Research studies have demonstrated that a protein found in wheat and gluten, known as gliadin, can increase the production of another protein known as zonulin. Zonulin can cause the tight junctions of the gut and BBB to become loose or broken, leading to a leaky brain and a leaky gut. �
Causes of a Leaky Brain
As previously mentioned above, a leaky gut is one of the most well-known causes of a leaky brain. Infections, autoimmune diseases, mental health issues, and stress or vagus nerve dysfunction are common factors that may also affect the blood-brain barrier. However, inflammation is generally the source of the problem in most of these brain and gut health issues. Below, we will discuss several factors that can ultimately cause a leaky brain in further detail. �
Infections can breakdown the BBB and allow bacteria to penetrate and enter the brain
Exposure to toxins can cause inflammation and oxidative stress in the brain which can affect the BBB
Too much glutamate can increase BBB permeability and permit passage to harmful components
Free radicals can also cause inflammation and promote aging, further affecting the blood-brain barrier
High blood sugar and diabetes can also cause oxidative stress and inflammation in the brain
Increased homocysteine, commonly found in people with heart health issues, autoimmune diseases, cancer, and neurological diseases, as well as in people who survive a stroke, can affect the tight junctions in the group of cells of the blood-brain barrier
High-fat, high-calorie diets and obesity can increase oxidative stress and prevent the brain from getting enough oxygen
Hypoxia causes the body to have an insufficient supply of oxygen which can further damage the tight junctions of the BBB
An injury or an underlying condition in the liver can release a signal, known as MMP9, that increases BBB permeability
Insufficient blood flow to the brain and abnormal activity in the brain, which is common in patients with mood changes
Poor sleep affects the sleep-wake cycle necessary in the uptake of nutrients and the offload of toxins which increases inflammation
Changes in the molecules found between the brain and bloodstream which develop tight junctions in the BBB.
Symptoms of a Leaky Brain
A leaky brain can ultimately cause a variety of symptoms. Because various factors may also cause the breakdown of the blood-brain barrier and allow harmful components to penetrate or enter the brain through the bloodstream, it’s essential to be aware of the type of symptoms that can manifest when you have a leaky brain. A leaky brain can cause a variety of symptoms as well as increase the risk of developing various brain health issues, including: �
Difficulty concentrating and memory loss, also known as brain fog
Sudden headaches or migraines that become worse throughout the day
Cognitive impairment that may ultimately lead to dementia and Alzheimer�s disease
Mood changes associated with anxiety, stress, depression, and schizophrenia
Chronic fatigue that doesn’t improve with rest or sleep
ADD/ADHD/Autism spectrum disorders
Brain health issues and neurological diseases, such as neuropathies or muscular sclerosis
Seizures and epilepsy
Too much inflammation may cause a variety of brain health issues and neurological diseases associated with the breakdown of the blood-brain barrier (BBB), also known as a leaky brain. Because many research studies have suggested the connection between a leaky gut and a leaky brain, maintaining a healthy gut microbiome may be an effective treatment for brain health issues and neurological diseases. Scientists have started working towards developing successful ways to allow drugs and/or medications as well as other treatments to penetrate and enter the brain through the blood-brain barrier and from the bloodstream. A leaky brain may be caused by a variety of factors and various symptoms can commonly manifest.� – Dr. Alex Jimenez D.C., C.C.S.T. Insight
Our brain is a complex organ that controls many essential functions in our body. Therefore, brain health is vital for our survival. This is where the blood-brain barrier comes in. The blood-brain barrier (BBB) consists of a group of cells held together by “tight junctions” that protect the brain from potentially harmful components in the bloodstream. This security system only permits passage to certain molecules and keeps most other chemicals or substances out. �
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.�
Curated by Dr. Alex Jimenez �
References:
Mindd Foundation. �What Causes Leaky Brain? Repairing the Blood-Brain Barrier.� Mindd, 11 June 2019, mindd.org/leaky-brain/.
Neurotransmitter Assessment Form
The following Neurotransmitter Assessment Form can be filled out and presented to Dr. Alex Jimenez. The following symptoms listed on this form are not intended to be utilized as a diagnosis of any type of disease, condition, or any other type of health issue. �
Additional Topic Discussion: Chronic Pain
Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals, however, chronic pain is different than the average type of pain. With chronic pain, the human body will continue sending pain signals to the brain, regardless if the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient’s mobility and it can reduce flexibility, strength, and endurance. �
Neural Zoomer Plus for Neurological Disease
Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual�s reactivity to 48 neurological antigens with connections to a variety of neurologically related diseases. The Vibrant Neural ZoomerTM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention. �
Food Sensitivity for the IgG & IgA Immune Response
Dr. Alex Jimenez utilizes a series of tests to help evaluate health issues associated with food sensitivities. The Food Sensitivity ZoomerTM is an array of 180 commonly consumed food antigens that offers very specific antibody-to-antigen recognition. This panel measures an individual�s IgG and IgA sensitivity to food antigens. Being able to test IgA antibodies provides additional information to foods that may be causing mucosal damage. Additionally, this test is ideal for patients who might be suffering from delayed reactions to certain foods. Utilizing an antibody-based food sensitivity test can help prioritize the necessary foods to eliminate and create a customized diet plan around the patient�s specific needs. �
Gut Zoomer for Small Intestinal Bacterial Overgrowth (SIBO)
Dr. Alex Jimenez utilizes a series of tests to help evaluate gut health associated with small intestinal bacterial overgrowth (SIBO). The Vibrant Gut ZoomerTM offers a report that includes dietary recommendations and other natural supplementation like prebiotics, probiotics, and polyphenols. The gut microbiome is mainly found in the large intestine and it has more than 1000 species of bacteria that play a fundamental role in the human body, from shaping the immune system and affecting the metabolism of nutrients to strengthening the intestinal mucosal barrier (gut-barrier). It is essential to understand how the number of bacteria that symbiotically live in the human gastrointestinal (GI) tract influences gut health because imbalances in the gut microbiome may ultimately lead to gastrointestinal (GI) tract symptoms, skin conditions, autoimmune disorders, immune system imbalances, and multiple inflammatory disorders. �
Formulas for Methylation Support
XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly,�Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic�Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
�
For your convenience and review of the XYMOGEN products please review the following link. *XYMOGEN-Catalog-Download �
* All of the above XYMOGEN policies remain strictly in force. �
If you are experiencing any of these problems or situations in your body, why don’t you try foods that are rich with antioxidants by using the ORAC.
Throughout scientific literature, it has been well established at how necessary the daily vegetable and fruit intake is for anyone’s physiological health and wellbeing. Not many people understand the importance of consuming more vegetables and fruit in their diet. Many healthcare professionals will often prescribe patients fruits and vegetables as well as more exercising, although some do not often explain why they should eat more fruits and vegetables.
Fruits and vegetables are filled with antioxidants like polyphenols, phytochemicals, and nutrients that are measured by their ORAC value. ORAC or oxygen radical absorbance capacity is a measurement of any food, spice, or nutrient/substance�s ability to get rid of oxidative free radicals in a test tube. What is interesting is that free radicals and reactive oxidative species (ROS) are synonymous. What this means is that essentially free radicals are unstable molecules that are produced under a normal metabolic process.
Free radicals can take the electrons from other molecules that are nearby in the body, which will cause a chain reaction consisting of oxidative stress and damage. When the body has continuous oxidative damage from inflammation, it can be a significant culprit to many degenerative conditions and age-related diseases, harming the person.
Many people would consider any medical diagnosis of any illnesses or diseases to be part of “normal” aging. With any conditions, people will accept and adapt to it, however, it may come as a shock for many people to find out that �age-related diseases� are not inevitable but a sign of unhealthy aging. Studies found out that cultures living in the blue zones are the healthiest cultures that have the highest life expectancy around the world. With these healthy cultures, they are a testament to anyone that aging does not equal to disease and poor health.
With healthy aging, it is defined as the metabolic age of being “younger than” the biological and chronological age. A journal review mentioned how to reduce systemic inflammation is the key to longevity and can prevent the development of the chronic disease. Studies were researching how risk factors for all-cause mortality and cardiovascular disease incidences in elders that live in Northern Greece. They found out that drinking coffee and tea, consuming fruit in vast quantities, and exclusive usage of olive oil was associated with cardiovascular diseases.
For anyone that is living in the blue zone, their diets and lifestyle factors are the primary determinants for their health and are the essential factors of longevity. The diets from the blue zones are usually plant-based, high in fiber and loads of vegetables, while also incorporating locally-caught fish that are rich in omega-3 fatty acids, this diet is similar to the Mediterranean-style diet.
ORAC Nutrients
There are a few specific vitamins and dietary compounds in food that have some of the highest ORAC values. One of the vitamins is vitamin E subfractions, especially delta-and gamma tocotrienols, which have a higher ORAC value than alpha-tocopherol while respectively contributing to substantially more significant health benefits. The two foods that are very high on the ORAC charts are cherries and elderberries. These two are highly nutritious due to phytonutrient-rich components like anthocyanins and quercetin. For vegetables, leafy greens like spinach and lycopene possess a high antioxidant profile.
In early 2019, a study showed how the consumption of spinach could help modulate the metabolism of lipids in the liver, while also finding out that the hepatic accumulation of alpha-carotene, beta-carotene, and lutein was correlated with blood glucose and total serum cholesterol. The many other fruits and vegetables that have antioxidants components that can help damp oxidative stress in the body and are highly nutritious for anyone to eat.
With many high ORAC fruits and vegetables can be condensed and form into supplements inside capsules and powders. Research shows that powdered greens that contain fruits and vegetable blends have become very popular amongst the health and wellness community. It makes sense due to that these capsules are loaded with antioxidant-rich phytochemicals that support the individual’s overall health. Since densely packed fruits and vegetable powders are great tools, some individuals would argue that these powders are not adequate amounts for a person�s diet.
With antioxidant-rich green powders, they are helpful for older adults who have limited mobility. For anyone that cannot prepare their meals, the powders can be blended with water or added to smoothies for optimal nutrition for the body. Another benefit that green powders have is that they can help counteract the deleterious effects of process food intake. For anyone unwilling to change their dietary patterns if they are taking particular nutrient-depleting medicine, as well as anyone who smokes or drinks alcohol, will suffer from chronic diseases in their body.
Conclusion
With the abundance of other compounds and foods that have a high ORAC value, any foods that have these antioxidants can help the body by removing inflammation in the joints and the gut, combating free radicals, and getting rid of oxidative stress that will cause systemic inflammation. By using the ORAC value system, finding food that has high antioxidant properties are essential. Even incorporating more fruits and vegetables in the diet is necessary for a healthy, functional body. Some products are formulated to help counter the metabolic effects of stress and support the gastrointestinal system in the body.
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.
References:
Barclay, Eliza. �Eating To Break 100: Longevity Diet Tips From The Blue Zones.� NPR, NPR, 11 Apr. 2015, www.npr.org/sections/thesalt/2015/04/11/398325030/eating-to-break-100-longevity-diet-tips-from-the-blue-zones.
Elvira-Torales, Laura In�s, et al. �Ameliorative Effect of Spinach on Non-Alcoholic Fatty Liver Disease Induced in Rats by a High-Fat Diet.� International Journal of Molecular Sciences, MDPI, 3 Apr. 2019, www.ncbi.nlm.nih.gov/pubmed/30987167.
Hossain, Afzal, et al. �Enhancement of Antioxidant Quality of Green Leafy Vegetables upon Different Cooking Method.� Preventive Nutrition and Food Science, The Korean Society of Food Science and Nutrition, Sept. 2017, www.ncbi.nlm.nih.gov/pubmed/29043220.
Liu, Qing, et al. �Comparison of Antioxidant Activities of Different Grape Varieties.� Molecules (Basel, Switzerland), MDPI, 23 Sept. 2018, www.ncbi.nlm.nih.gov/pubmed/30249027.
Pisoschi, Aurelia Magdalena, et al. �Antioxidant Capacity Determination in Plants and Plant-Derived Products: A Review.� Oxidative Medicine and Cellular Longevity, Hindawi Publishing Corporation, 2016, www.ncbi.nlm.nih.gov/pubmed/28044094.
Team, DFH. �Cherries: Whats Not to Love?� Designs for Health, 5 Jan. 2018, blog.designsforhealth.com/cherries-whats-not-to-love.
Team, DFH. �Elevate the Immune System with Elderberry.� Designs for Health, 5 Jan. 2018, blog.designsforhealth.com/elevate-the-immune-system-with-elderberry-0.
Team, DFH. �Tocotrienols.� Designs for Health, 7 Dec. 2018, blog.designsforhealth.com/node/909.
Tsoupras, Alexandros, et al. �Inflammation, Not Cholesterol, Is a Cause of Chronic Disease.� Nutrients, MDPI, 12 May 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC5986484/.
Weil, Andrew. �ORAC: Scoring Antioxidants? – Dr. Weil.� DrWeil.com, 5 Aug. 2016, www.drweil.com/vitamins-supplements-herbs/vitamins/orac-scoring-antioxidants/.
According to the National Institute of Mental Health (NIH), approximately 20 percent of the population in the United States are diagnosed with a brain health issue every year, with depression and phobias being the most common types of diagnosable mental health issues. Moreover, the Centers for Disease Control and Prevention (CDC) reported that the suicide rate in the United States had reached 13 for every 100,000 people in 2014, which is the highest it had ever been since 1986. Scientists are starting to associate brain health issues with inflammation and its effects on the blood-brain barrier. �
The blood-brain barrier (BBB) is a connection of blood vessels that protect the brain against harmful free radicals in the bloodstream. However, the blood-brain barrier is so effective at protecting the brain from these “harmful” components in the bloodstream, that it can ultimately even prevent drugs and/or medications from penetrating this security system to treat brain health issues. A research study published in Psychotherapy and Psychosomatics demonstrated that the effectiveness of antidepressants is only slightly more effective compared to placebos in the treatment of mental health issues. �
What Causes a Leaky Brain?
Scientists continue to analyze ways to effectively penetrate the blood-brain barrier to treat brain health issues. Several research studies have also determined that inflammation may reduce the function of brain cells in the frontal lobe of people diagnosed with depression. Other scientists are starting to believe that antidepressants and medicines used to treat depression are ineffective because these don’t necessarily treat inflammation in the brain. When the blood-brain barrier is damaged or injured, harmful components can enter the brain through the bloodstream and cause neurodegenerative symptoms. �
A “leaky brain” is a well-known term that is increasingly being used to describe blood-brain barrier permeability. A variety of blood tests, including those that measure the levels of the proteins occludin and zonulin, can be used to determine a leaky brain. Immunoglobulin levels may also be measured. Scientists also measure the levels of a molecule, known as microRNA-155, which increases with inflammation. MicroRNAs (miRNAs) play the fundamental role of regulating immune reactions, with miR-155 as a biomarker for inflammation in the brain due to a leaky blood-brain barrier. According to various research studies, this molecule can cause small gaps to develop in the BBB which can ultimately cause inflammation and lead to a leaky brain. �
Several different research studies have also discussed how inflammation on the blood-brain barrier can eventually cause a leaky brain. Meanwhile, other research studies have demonstrated a link between inflammation and a variety of psychiatric disorders. Scientists also demonstrated that pro-inflammatory cytokines can increase and cause increased blood-brain barrier permeability. Many harmful components can also affect the structure of the mitochondria and the blood-brain barrier. Microglial cells in the brain may also trigger and activate the release of molecules that can further affect the BBB. �
Further evidence has also associated blood-brain barrier dysfunction with a leaky gut. Scientists have suggested treating an underlying leaky gut to help treat a leaky brain. According to research studies, intestinal permeability, or a �leaky gut�, may ultimately be associated with blood-brain barrier permeability. Bacteria, small molecules, and toxins in the blood are commonly found in celiac disease, a well-known problem caused by gluten sensitivity or intolerance. Although true celiac disease is considered to be rare, a leaky gut associated with celiac disease and brain health issues are considered to be more common. �
One research study discusses the connection between the gut microbiome, inflammation, and the integrity of the blood-brain barrier. The scientists of a different research study discussed how a variety of treatments used to help improve the biodiversity of the gut microbiome, including a healthy diet and lifestyle modifications, fecal microbiota transplantation, prebiotics, and probiotics, have demonstrated to support the function of the gut-brain axis. Scientists believe it will be possible to use the gut microbiome to improve brain and mental health issues as well as to prevent further complications. �
Too much inflammation may cause a variety of brain and mental health issues associated with blood-brain barrier permeability. Because many research studies have suggested the connection between a leaky gut and a leaky brain, maintaining a healthy gut microbiome may be an effective treatment for brain and mental health. Although the brain is protected by the blood-brain barrier, this security system can frequently prevent drugs and/or medications from being able to effectively treat many brain and mental health issues. Scientists have started working towards developing successful ways to allow treatments to penetrate the blood-brain barrier.� – Dr. Alex Jimenez D.C., C.C.S.T. Insight
As previously mentioned, the National Institute of Mental Health (NIH) states that about 20 percent of Americans are diagnosed with a mental health issue every year, where depression and phobias are considered to be the most common types of diagnosable brain health issues. Furthermore, the Centers for Disease Control and Prevention (CDC) recorded that the suicide rate in the United States reached 13 for every 100,000 people in 2014, which is the highest it has ever been since 1986. Scientists associate mental health issues with brain inflammation and how it causes a “leaky” blood-brain barrier. �
The blood-brain barrier (BBB) is a group of blood vessels that protect the brain against “harmful” components in the bloodstream. However, because the blood-brain barrier can be so effective at protecting the brain from these harmful free radicals in the bloodstream, it can ultimately prevent drugs and/or medications from successfully penetrating the BBB to treat mental health issues. Research studies published in Psychotherapy and Psychosomatics determined that the effectiveness of certain medicines can only be slightly more effective, compared to placebos, in the treatment of brain health issues. �
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.�
Curated by Dr. Alex Jimenez �
References:
Figeley, Melanie. �Do You Have A Leaky Brain?� Biotics NW Inc., Biotics NW Inc., 15 Jan. 2019, www.bioticsnw.com/blogs/news/do-you-have-a-leaky-brain.
Neurotransmitter Assessment Form
The following Neurotransmitter Assessment Form can be filled out and presented to Dr. Alex Jimenez. The following symptoms listed on this form are not intended to be utilized as a diagnosis of any type of disease, condition, or any other type of health issue. �
Additional Topic Discussion: Chronic Pain
Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals, however, chronic pain is different than the average type of pain. With chronic pain, the human body will continue sending pain signals to the brain, regardless if the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient’s mobility and it can reduce flexibility, strength, and endurance. �
Neural Zoomer Plus for Neurological Disease
�
Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual�s reactivity to 48 neurological antigens with connections to a variety of neurologically related diseases. The Vibrant Neural ZoomerTM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention. �
Food Sensitivity for the IgG & IgA Immune Response
�
Dr. Alex Jimenez utilizes a series of tests to help evaluate health issues associated with food sensitivities. The Food Sensitivity ZoomerTM is an array of 180 commonly consumed food antigens that offers very specific antibody-to-antigen recognition. This panel measures an individual�s IgG and IgA sensitivity to food antigens. Being able to test IgA antibodies provides additional information to foods that may be causing mucosal damage. Additionally, this test is ideal for patients who might be suffering from delayed reactions to certain foods. Utilizing an antibody-based food sensitivity test can help prioritize the necessary foods to eliminate and create a customized diet plan around the patient�s specific needs. �
Gut Zoomer for Small Intestinal Bacterial Overgrowth (SIBO)
�
Dr. Alex Jimenez utilizes a series of tests to help evaluate gut health associated with small intestinal bacterial overgrowth (SIBO). The Vibrant Gut ZoomerTM offers a report that includes dietary recommendations and other natural supplementation like prebiotics, probiotics, and polyphenols. The gut microbiome is mainly found in the large intestine and it has more than 1000 species of bacteria that play a fundamental role in the human body, from shaping the immune system and affecting the metabolism of nutrients to strengthening the intestinal mucosal barrier (gut-barrier). It is essential to understand how the number of bacteria that symbiotically live in the human gastrointestinal (GI) tract influences gut health because imbalances in the gut microbiome may ultimately lead to gastrointestinal (GI) tract symptoms, skin conditions, autoimmune disorders, immune system imbalances, and multiple inflammatory disorders. �
Formulas for Methylation Support
� XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly,�Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic�Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
�
For your convenience and review of the XYMOGEN products please review the following link. *XYMOGEN-Catalog-Download �
* All of the above XYMOGEN policies remain strictly in force. �
How often do you feel agitated, easily upset, and nervous between meals? How often do you have difficulty concentrating before eating? How often does your energy level drop in the afternoon? Inflammation associated with a leaky blood-brain barrier can cause a variety of brain health issues. Our brain is a complex organ that controls various structures and functions of our body, from our memory to our breathing, muscle movements, and hormones. �
Unfortunately, brain health issues are common in our society. According to the National Institute of Mental Health, approximately 20 percent of adults in the United States have a brain health issue and American adults spend about $113 billion on treatment every year. Additionally, these statistics don’t even include the treatment cost of autoimmune brain health issues, such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and autism. In the article below, we will discuss how inflammation is associated with a “leaky” blood-brain barrier and what you can do to improve a variety of brain health issues. �
“Leaky” Blood-Brain Barriers and Inflammation
Scientists have previously discussed how leaky gut syndrome, a well-known digestive health issue that affects the lining of the gastrointestinal (GI) tract, can be associated with various health issues. However, current research studies have shown that leaky gut syndrome may also be associated with a leaky blood-brain barrier or the breakdown of the blood-brain barrier.�The gut-brain connection ultimately suggests that a “leaky gut” may cause a “leaky brain”. �
Biomarkers using the proteins occludin and zonulin can help determine the presence of leaky gut syndrome and a leaky blood-brain barrier. Scientists have demonstrated that increased antibodies against occludin and zonulin are one way to determine leaky brain syndrome. Scientists have also demonstrated that a molecule known microRNA-155 can increase with inflammation. MicroRNA-155 can ultimately cause microscopic gaps to develop in the blood-brain barrier that permitted passage to “harmful” components. This permeability can trigger the brain’s immune system and cause brain inflammation. �
Various research studies from the cytokine model of cognitive function evaluated how brain inflammation and a leaky blood-brain barrier may be associated with cases of anxiety, depression, brain fog, and autoimmune brain health issues. By way of instance, scientists evaluated how inflammation can decrease the activation of brain cells in the frontal lobe of people with depression. In cases of brain inflammation, using drugs and/or medications, such as antidepressants, are frequently ineffective because they aren’t treating the underlying brain inflammation. If a patient suffers from anxiety, depression, brain fog, or autoimmune brain health issues, many healthcare professionals may suggest the presence of a leaky brain or a leaky blood-brain barrier. �
8 Steps to Improve a Leaky Blood-Brain Barrier
Inflammation and a leaky blood-brain barrier may ultimately cause a variety of bran health issues if it’s misdiagnosed and left untreated. If you suspect you may have anxiety, depression, brain fog, or autoimmune brain health issues due to inflammation associated with a leaky blood-brain barrier, it’s important to talk to a healthcare professional to receive proper diagnosis and treatment. Fortunately, there are steps you can take to improve a leaky blood-brain barrier:� �
Evaluate your blood-brain barrier by conducting labs for blood-brain barrier proteins, which can show BBB permeability, occludin and zonulin, which can show the antibodies against these proteins, homocysteine, which shows blood-brain barrier damage or injury through the increased levels of this amino acid, and brain agers like inflammation, which can accelerate the aging of the brain. High blood sugar may also show BBB permeability.
Determine a “leaky” blood-brain barrier by conducting microbiome labs. A “leaky gut” can cause a “leaky brain”. Understanding the gut-brain axis can help determine the presence of any underlying brain health issues. Bacterial imbalances and yeast overgrowths can cause neurological symptoms. By way of instance, anxiety and depression are associated with the bacteria known as Lactobacillus helveticus and Bifidobacterium longum.
Prevent yourself from eating foods, such as processed, refined and sugary foods as well as other toxins, that can cause a leaky blood-brain barrier.
Regulate stress for overall brain health. Research studies ultimately suggest that acute stress can increase the breakdown of the blood-brain barrier. Tai chi, yoga, and mindfulness meditation are several effective ways to help manage stress for the overall well-being of the human brain.
Take natural compounds, such as apigenin, baicalein, catechins, curcumin, luteolin, resveratrol, and rutin, that have all been suggested to reduce brain inflammation. However, because the correct dosage will be different for everyone, make sure to talk to a doctor before taking natural medicine.
Participate in exercise and physical activity that can help increase a brain-derived neurotrophic factor, BDNF, which helps promote brain health.
Reduce your consumption of alcohol. Alcohol can stress the brain and several research studies suggest that it can affect the blood-brain barrier.
Consider visiting a functional medicine practitioner to improve a leaky blood-brain barrier. While there’s no immediate fix for many chronic brain health issues, functional medicine customizes diagnostics and natural protocols based on your unique needs to help promote overall well-being.
The brain is protected by the blood-brain barrier, however, this security system can frequently prevent drugs and/or medications from being able to effectively treat brain health issues. Scientists have started working towards developing successful ways to allow treatments to penetrate the blood-brain barrier. Other research studies have demonstrated that the aging brain or neurodegeneration can cause the breakdown of the blood-brain barrier. However, research studies have demonstrated ways to restore and even reverse leaky blood-brain barriers and several brain health issues. Patients can take several steps to help improve a leaky blood-brain barrier. – Dr. Alex Jimenez D.C., C.C.S.T. Insight
How often do you feel agitated, easily upset, and nervous between meals? How often do you have difficulty concentrating before eating? How often does your energy level drop in the afternoon? Inflammation associated with a leaky blood-brain barrier can cause a variety of brain health issues. Our brain is a complex organ that controls various structures and functions of our body, from our memory to our breathing, muscle movements, and hormones. �
Unfortunately, brain health issues are common in our society. According to the National Institute of Mental Health, approximately 20 percent of adults in the United States have a brain health issue and American adults spend about $113 billion on treatment every year. Additionally, these statistics don’t even include the treatment cost of autoimmune brain health issues, such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and autism. In the article above, we discussed how inflammation is associated with a “leaky” blood-brain barrier and what you can do to improve a variety of brain health issues. �
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.�
Curated by Dr. Alex Jimenez �
References:
Cole, William. �Signs You Might Have A �Leaky Brain� + What To Do About It.� Mindbodygreen, Mindbodygreen, 22 July 2015, www.mindbodygreen.com/0-20800/signs-you-might-have-a-leaky-brain-what-to-do-about-it.html.
Neurotransmitter Assessment Form
The following Neurotransmitter Assessment Form can be filled out and presented to Dr. Alex Jimenez. The following symptoms listed on this form are not intended to be utilized as a diagnosis of any type of disease, condition, or any other type of health issue. �
Additional Topic Discussion: Chronic Pain
Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals, however, chronic pain is different than the average type of pain. With chronic pain, the human body will continue sending pain signals to the brain, regardless if the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient’s mobility and it can reduce flexibility, strength, and endurance. �
Neural Zoomer Plus for Neurological Disease
Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual�s reactivity to 48 neurological antigens with connections to a variety of neurologically related diseases. The Vibrant Neural ZoomerTM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention. �
Food Sensitivity for the IgG & IgA Immune Response
Dr. Alex Jimenez utilizes a series of tests to help evaluate health issues associated with food sensitivities. The Food Sensitivity ZoomerTM is an array of 180 commonly consumed food antigens that offers very specific antibody-to-antigen recognition. This panel measures an individual�s IgG and IgA sensitivity to food antigens. Being able to test IgA antibodies provides additional information to foods that may be causing mucosal damage. Additionally, this test is ideal for patients who might be suffering from delayed reactions to certain foods. Utilizing an antibody-based food sensitivity test can help prioritize the necessary foods to eliminate and create a customized diet plan around the patient�s specific needs. �
Gut Zoomer for Small Intestinal Bacterial Overgrowth (SIBO)
Dr. Alex Jimenez utilizes a series of tests to help evaluate gut health associated with small intestinal bacterial overgrowth (SIBO). The Vibrant Gut ZoomerTM offers a report that includes dietary recommendations and other natural supplementation like prebiotics, probiotics, and polyphenols. The gut microbiome is mainly found in the large intestine and it has more than 1000 species of bacteria that play a fundamental role in the human body, from shaping the immune system and affecting the metabolism of nutrients to strengthening the intestinal mucosal barrier (gut-barrier). It is essential to understand how the number of bacteria that symbiotically live in the human gastrointestinal (GI) tract influences gut health because imbalances in the gut microbiome may ultimately lead to gastrointestinal (GI) tract symptoms, skin conditions, autoimmune disorders, immune system imbalances, and multiple inflammatory disorders. �
Formulas for Methylation Support
� XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly,�Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic�Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
�
�
For your convenience and review of the XYMOGEN products please review the following link. *XYMOGEN-Catalog-Download �
* All of the above XYMOGEN policies remain strictly in force. �
If you are experiencing any of these situations, then you might be experiencing some gut and liver issues in your body.
The role of the gut-liver axis in NAFLD (non-alcoholic fatty liver disease) has been examining probiotics and have found some new information on the gut microbiome and how probiotics work in NAFLD. The new information that future research found was quite interesting. It stated that there were about 26 major randomized controlled trials that used probiotics for NALFD that ranged between 20 to 200 individuals in four weeks to 1 year. The laboratory assessments included liver enzymes and anthropometric parameters in the body. Some of the studies added cardiovascular risk factors like C-reactive proteins and lipid profiles as markers for insulin resistance. Furthermore, most of the studies have used a probiotic formulation that includes multiple species, although a few were conducted by using a single strain.
What NAFLD does to the body is that it becomes a hepatic consequence of metabolic syndrome. This includes obesity, diabetes, and dyslipidemia. What is interesting about the connection between gut microbiota and NAFLD has been attracting a significant amount of attention in recent years. The data has shown that the gut microbiota can affect the hepatic lipid metabolism while also influencing the balance between pro/anti-inflammatory effectors in the liver.
Chronic Liver Diseases
Even though chronic liver disease is the primary cause of morbidity and mortality worldwide. Studies showed that gut dysbiosis was identified as an essential factor in the pathogenesis of the liver disease. The relationship between the gut microbiota and the liver is still not understood, but the dysfunction of leaky gut and an increased bacterial translocation into the liver. Another study showed that immense importance is a massive advancement in understanding the roles of the gut and liver microbiome that is driven by a high DNA sequencing and improving them.
There are many stages of liver disease that can happen, but when it comes to excessive alcohol in the liver. Studies show that excessive alcohol consumption is the leading cause of chronic liver disease worldwide. The stages of alcoholic liver disease are hepatic steatosis, steatohepatitis, and, ultimately, liver cirrhosis. One of the main characteristics of alcohol liver disease is that there is an increased gut permeability due to a direct toxic effect of alcohol on the epithelial cell in the gastrointestinal tract and a decreases expression of the tight-junction protein.
Probiotic Supplements
For probiotic supplementation, they have demonstrated a significant decrease in liver enzymes, which were compared to the placebo group. Studies found that probiotics were shown to have synergistic effects with metformin on liver enzymes for patients that have NASH. Any products that contained both prebiotics and probiotics can demonstrate a similar effect in the probiotic groups. In another study, it showed a reduction of intrahepatic fat that is measured by MRI, but the improvement in liver enzymes in the body did not reach any clinical significance. It is essential to know that liver enzymes can have a highly variable and do not always have a direct correlation with disease progression that they may encounter.
Research shows that there are five meta-analyses included and that they all demonstrated that probiotics and synbiotics have improved on AST and ALT levels in the body significantly. Surprisingly, several other studies have assisted probiotics by countering hepatic steatosis, fibrosis, and liver stiffness in the body. Ultrasound imaging can help assist these parameters and show some positive clinical outcomes with these two supplements.
When probiotics help restore the gastrointestinal barrier function in the body, they can eliminate the harmful bacteria that has interacted with the gastrointestinal system. Not only that, but probiotics can also be beneficial by modulating the immune system, reduce liver fats, and improve the liver enzymes as well. By using probiotics, they are most likely to be more productive by helping the body and preventing bacterial translocation in the gut, thus reducing the effects of the intestinal microbiota on the liver to prevent chronic illnesses from forming and causing havoc.
Conclusion
For individuals that have NAFLD, they will already establish the disease and required a higher nutrient intake demand than what can be obtained from any diets alone. So using dietary supplements should be considered to help reduce the NAFLD disease’s progression, thus improving the liver and its functions. The gut-liver axis is connected to the body since if anything happens to the liver like chronic diseases, it can affect the gut as well. Using probiotics to help the liver is essential to make sure that the liver is functioning correctly and that the body is being as healthy as possible. Some products are here to offer gastrointestinal and metabolic support while also supporting multiple aspects of the biliary system.
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.
References:
Jurgelewicz, Michael. �New Review Demonstrates the Role of the Gut Microbiome and Probiotics in Nonalcoholic Fatty Liver Disease.� Designs for Health, 25 Nov. 2019, blog.designsforhealth.com/node/1160.
Konturek, Peter Christopher, et al. �Gut?Liver Axis: How Do Gut Bacteria Influence the Liver?� Medical Sciences (Basel, Switzerland), MDPI, 17 Sept. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6165386/.
Tripathi, Anupriya, et al. �The Gut-Liver Axis and the Intersection with the Microbiome.� Nature Reviews. Gastroenterology & Hepatology, U.S. National Library of Medicine, July 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6319369/.
Xie, Chencheng, and Dina Halegoua DeMarzio. “Role of Probiotics in Nonalcoholic Fatty Liver Disease: Does Gut Microbiota Matter?” MDPI, Multidisciplinary Digital Publishing Institute, 19 Nov. 2019, www.mdpi.com/2072-6643/11/11/2837.
IFM's Find A Practitioner tool is the largest referral network in Functional Medicine, created to help patients locate Functional Medicine practitioners anywhere in the world. IFM Certified Practitioners are listed first in the search results, given their extensive education in Functional Medicine
�
�
�
