Microbes have multicellular hosts and can have many effects on the host�s health and well-being. Researchers have stated that microbes influence metabolism, immunity, and behavior on the human body. One of the most important but understudied mechanisms that microbes have is that they can involve hormones. In the presence of gut microbiota, specific changes in hormone levels can correlate in the gut. The gut microbiota can produce and secrete hormones, respond to the host hormones, and regulate their expression levels. There is also a link between the endocrine system and the gut microbiota as more information is still being researched.
The Gut to Hormone Connection
Since the human microbiome contains a vast array of microbes and genes that shows a higher complexity. Unlike other organs in the body, the gut microbiota’s function is not fully understood yet but can be disrupted easily by antibiotics, diet, or surgery. The best-characterized function is how the gut microbiota interacts with the endocrine system in the body.
Emerging research has indicated that the gut microbiome plays a central role in regulating estrogen levels within the body. When the estrogen hormone levels are too high or too low, it can lead to the risk of developing estrogen-related diseases like endometriosis, polycystic ovary syndrome, breast cancer, and prostate cancer to males and females.
The gut to hormone connection is essential since the gut is one of the producers to create hormones that travel through the entire body system. With the endocrine system is being involved, it is the first network to produce and transport hormones to the organs that need the hormones to function. When there is an imbalance of hormones in the human body, it can disrupt all the other hormones.
The gut microbiota influences nearly every hormone that the endocrine system creates, including:
The thyroid hormones
Estrogen hormones
Stress hormones
Thyroid Hormones
If the gut has inflammation, then the hormones in the body will create an excessive or low quantity in the body. If the endocrine glands like thyroid, are producing a low quantity of hormones and the gut can be imbalanced and lead to hypothyroidism. When there is low microbial diversity in the gut, studies have shown that the low microbial diversity is linked to high TSH (thyroid-stimulating hormone) levels. The excessive quantity of thyroid hormones can lead to hyperthyroidism. Both hyperthyroidism and hypothyroidism can cause symptoms like irritability, anxiety, poor memory, and many symptoms that can affect the body.
“If you are experiencing excessive belching, burping, bloating, difficult bowel movements difficulty digesting proteins and meats; undigested food found in stools, digestive problems subside with rest and relaxation or any symptoms. Then this article will give you a better understand what is happening with the gut and how hormones can affect the gut system.”
Estrogen Hormones
The gut and an individual’s hormones are meant to be in communication with each other. They not only support each other, but they also work together to make sure the body is running smoothly. Studies have found out that the gut’s intestinal cells have special receptors for hormones that allow them to detect any hormonal shifts that affect the body.
Since estrogen is typically associated with women, it is common that men need the right amount of estrogen levels to function. The gut microbiota is the key regulator of leveling and circulating estrogen in the body. The microbes produce an enzyme called beta-glucuronidase, which then converts the estrogen hormone to its active form.
The gut microbiome can regulate estrogen levels by functioning a specific bacteria in the microbiome called estrobolome. Estrobolome is the aggregates of enteric bacterial genes that are capable of metabolizing estrogen. It might affect women’s risk of developing postmenopausal estrogen receptor-positive breast cancer. The estrobolome is highly essential to keep estrogen levels in the body at a stable state.
In the gut microbiota, both the estrogen and progesterone hormones can impact the guts’ motility and peristalsis ( The rhythmic movement of the intestines that move food through the stomach and out of the body) by playing opposing roles in the guts� motility. Progesterone helps slow down the gut�s motility by relaxing the smooth and slowing transit the time the food is moving out of the body. Estrogen helps increase the contraction of the smooth muscles in the intestines. When the estrogen hormones are leveled right, it can help keep the gut moving smoothly and help increase the diversity of the body�s microbiomes, which is a good thing for the immune system.
Stress Hormones
Stress hormones or cortisol plays a massive part in the gut microbiota. Since cortisol hormones connect to the brain, it sends the signals to the gut and vice versa. If it is a short stressor like getting ready for a presentation or a job interview, the person will feel “butterflies” in their gut. The longer stressors, for example, like having a highly stressful job or feeling anxious consistently, can lead to chronic illnesses in the gut like inflammation or leaky gut. Since the hormone and gut connection is in sync with the gut and brain connection, it is crucial to lowering the cortisol levels to a stable state for a healthy functional body.
Conclusion
The gut and hormone connections are profoundly meaningful since they are linked closely together. When there is a disruption on the gut, it can cause hormones to be imbalanced, causing many disruptions like inflammation and leaky gut. When there is a disruption in the hormones, it can disrupt the gut as well by negatively shifting the gut’s microbiome. So to ensure that the gut is functioning correctly, it is crucial to eat food that contains probiotics and is fermented to keep the gut flora healthy. Some products can help counter the metabolic effects of temporary stress and supporting estrogen metabolism by incorporating other essential nutrients and cofactors to support the endocrine system.
October is Chiropractic Health Month. To learn more about it, check out Governor Abbott�s declaration on our website to get full details on this historic moment.
The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or chronic disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .
References:
Author, Guest. �How Your Gut Microbiome Influences Your Hormones.� Bulletproof, 21 Aug. 2019, www.bulletproof.com/gut-health/gut-microbiome-hormones/.
Evans, James M, et al. �The Gut Microbiome: the Role of a Virtual Organ in the Endocrinology of the Host.� The Journal of Endocrinology, U.S. National Library of Medicine, 28 Aug. 2013, www.ncbi.nlm.nih.gov/pubmed/23833275.
Kresser, Chris. �The Gut�Hormone Connection: How Gut Microbes Influence Estrogen Levels.� Kresser Institute, Kresserinstitute.com, 10 Oct. 2019, kresserinstitute.com/gut-hormone-connection-gut-microbes-influence-estrogen-levels/.
Kwa, Maryann, et al. �The Intestinal Microbiome and Estrogen Receptor-Positive Female Breast Cancer.� Journal of the National Cancer Institute, Oxford University Press, 22 Apr. 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC5017946/.
Neuman, Hadar, et al. �Microbial Endocrinology: the Interplay between the Microbiota and the Endocrine System.� OUP Academic, Oxford University Press, 20 Feb. 2015, academic.oup.com/femsre/article/39/4/509/2467625.
Szkudlinski, Mariusz W, et al. �Thyroid-Stimulating Hormone and Thyroid-Stimulating Hormone Receptor Structure-Function Relationships.� Physiological Reviews, U.S. National Library of Medicine, Apr. 2002, www.ncbi.nlm.nih.gov/pubmed/11917095.
Wieselman, Brie. �Why Your Gut Health and Microbiome Make-or-Break Your Hormone Balance.� Brie Wieselman, 28 Sept. 2018, briewieselman.com/why-your-gut-health-and-microbiome-make-or-break-your-hormone-balance/.
According to the World Health Organization, depression is one of the main causes of disability worldwide. Moreover, approximately 30 percent to 60 percent of patients don’t respond to the currently available antidepressant treatments. That means that about 40 percent to 70 percent of patients aren’t being helped by existing antidepressant treatments. One region of research studies can ultimately shed some light on why many patients are not helped by antidepressants. �
Neuroinflammation and Mood Changes
Increasing evidence from these research studies shows that brain inflammation can aggravate or even increase symptoms of depression. Inflammation is a fundamental part of the immune system. When the human body is affected by toxins, bacteria, viruses, or parasites, the immune system recruits cells, proteins, and other structures, to attack these invaders. The main purpose is to indicate the injured body parts so that we can pay more attention. Inflammation makes affected body parts reddish, swollen, and hot. After the injury isn’t localized, then the nervous system can become inflamed. Neuroinflammation can ultimately contribute to “mood changes.” These can also include cognitive, physical, and behavioral changes. �
Generally, people with depression experience sleepiness, fatigue, slow response time, cognitive impairments, and loss of sexual desire. This collection of changes causes people to want to get more sleep to heal themselves and remain isolated so as to not spread infections. However, prolonged inflammation can wreak havoc in the human body and it can increase the risk of depression and other illnesses. Increased evidence shows the link between brain inflammation and depression. �
By way of instance, markers of inflammation are increased in people who suffer from depression in contrast to non-depressed types, according to research studies. Furthermore, indicators of inflammation may also predict the intensity of gastrointestinal tract symptoms associated with depression. A research study that examined twins which share 100 percent of the same genes found that the twin who had a greater CRP concentration, a common measure of inflammation, was more prone to develop depression five years later. Doctors also noticed that cancer and Hepatitis C patients treated with IFN-alpha treatment, which increases the human body’s inflammatory response, also suffered from depression later in life. �
This treatment increased the discharge of pro-inflammatory cytokines, which increased the reduction of appetite, sleep disturbances, anhedonia or lack of enjoyment, cognitive impairment, and suicidal ideation, according to research studies. The incidence of depression in these patients has increased. Additionally, these results provided further evidence for the connection between inflammation and depression. Subsequent, careful research studies also demonstrated that the increase in the prevalence of depression in patients treated with IFN-alpha was not only due to the previously presented problem. �
Depression and Brain Inflammation in Functional Neurology
Utilizing a very simple way of injecting healthy subjects with immune system invaders, researchers found higher levels of depressive symptoms from the ones who were more vulnerable compared to the placebo group. The subjects that were provided with an inflammatory response complained of symptoms, such as negative mood, anhedonia, sleep disturbances, social withdrawal, and cognitive impairments. The link between inflammation and depression is much more powerful for patients that don’t respond to current antidepressant treatments. Various studies have revealed that treatment-resistant patients tend to have elevated inflammatory aspects circulating at baseline compared to responsive ones. �
This is clinically significant because a clinician can utilize CRP levels, which are part of a regular physical exam, to predict the treatment response to antidepressants. In one research study, they found that increased levels of an inflammation molecule before treatment predicted poor response to antidepressants. There are environmental factors that cause inflammation and increase the risk of depression, including stress, low socioeconomic status, or even a troubled childhood. Additionally, an increased inflammatory response leads to greater sensitivity to stress. The result was reported in research studies in mice. �
By way of instance, mice that have gone under chronic unpredictable stress have higher levels of inflammation markers. Surprisingly, there are individual differences that make some mice resistant to stress, therefore, initiating a calmer immune response. Depression is a heterogeneous disorder. Each individual’s struggle is unique given their youth, genetics, the sensitivity of their immune system, other existing bodily illnesses, and their current status in society. Being around the disadvantageous end of the dimensions disrupts our immune system and causes chronic inflammation. �
The mind is very responsive to those circulating inflammatory markers and initiates “illness behavior”. When the inflammation is prolonged by stressors or other vulnerabilities, the illness behavior becomes depression. If you are a healthcare professional working with people that have depression, it’s fundamental to look at the health of the patients’ immune systems. If you are a patient experiencing an exaggerated immune disorder (e.g., arthritis), don’t discount the depressive symptoms that you might be experiencing. If you are currently suffering from depression, prevent anything that might exacerbate your reaction. After all, treating the root of the health issue may ultimately improve depression. �
Brain inflammation has been associated with a variety of signs and symptoms, including mood changes like anxiety and depression. Inflammation in the brain can also cause a variety of neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease. Inflammation is an essential function of the immune system, however, excess brain inflammation, can cause anxiety, depression, and other health issues. In the following article, inflammation and mood changes, such as depression, can cause a variety of symptoms, including fatigue and cognitive impairment. – Dr. Alex Jimenez D.C., C.C.S.T. Insight
Metabolic Assessment Form
The following Metabolic Assessment Form can be filled out and presented to Dr. Alex Jimenez. Symptom groups listed on this form are not intended to be utilized as a diagnosis of any type of disease, condition, or any other type of health issue. �
In honor of Governor Abbott’s proclamation, October is Chiropractic Health Month. Learn more about the proposal. �
According to the World Health Organization, depression is one of the main causes of disability worldwide. Moreover, approximately 30 percent to 60 percent of patients don’t respond to the currently available antidepressant treatments. That means that about 40 percent to 70 percent of patients aren’t being helped by existing antidepressant treatments. One region of research studies can ultimately shed some light on why many patients are not helped by antidepressants.�The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or chronic disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 . �
Curated by Dr. Alex Jimenez �
References: �
Haapakoski, R., Mathieu, J., Ebmeier, K.P., Alenius, H., Kivim�ki, M., 2015. Cumulative meta-analysisofinterleukins6 and 1?,tumournecrosisfactor? and C-reactive protein in patients with major depressive disorder. Brain Behav.Immun. 49,206. �
Hodes GE, Pfau ML, Leboeuf M, Golden SA, Christoffel DJ, Bregman D et al (2014). Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress. Proc Natl Acad Sci USA 111: 16136�16141. �
Krishnan V, Nestler EJ (2008). The molecular neurobiology of depression. Nature 455: 894�902. �
Lotrich, F.E., Rabinovitz, M., Gironda, P., Pollock, B.G., 2007. Depression following pegylated interferon-alpha: characteristics and vulnerability.J.Psychosom.Res.63, 131�135.doi.org/10.1016/j.jpsychores.2007.05.013. �
O’Brien, S.M., Scully, P., Fitzgerald, P., Scott, L.V., Dinan, T.G., 2007a. Plasma cytokine profiles in depressed patients who fail to respond to selective serotonin reuptake inhibitor therapy. J. Psychiatr. Res. 41, 326e331. �
Tianzhu, Z., Shihai, Y., Juan, D., 2014. Antidepressant-like effects of cordycepin in a mice model of chronic unpredictable mild stress. Evid. Based Complement. Altern. Med. 2014, 438506.
Additional Topic Discussion: Chronic Pain
Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals, however, chronic pain is different than the average type of pain. With chronic pain, the human body will continue sending pain signals to the brain, regardless if the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient’s mobility and it can reduce flexibility, strength, and endurance.
Neural Zoomer Plus for Neurological Disease
Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual�s reactivity to 48 neurological antigens with connections to a variety of neurologically related diseases. The Vibrant Neural ZoomerTM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention. �
Formulas for Methylation Support
XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly,�Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic�Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
�
For your convenience and review of the XYMOGEN products please review the following link.*XYMOGEN-Catalog-Download �
* All of the above XYMOGEN policies remain strictly in force.
A look at what a stinger or burner injury is and what they can do to the neck and shoulders. We will look at:
Symptoms
Treatment
Prevention
Contact sports, like:
Football
Hockey
Soccer
Basketball
This is a very common cervical injury that affects the neck and upper body. This is known as a stinger.
A stinger can also be called a burner and is an injury that happens when the head or neck gets hit to one side, which causes the shoulder to be pulled in the opposite direction.
Stingers/burners often happen at the high school level but can occur at all levels of play.
Stinger/Burner neck injury cause
A stinger is caused by stretching the brachial plexus nerves.
These peripheral nerves that come out of:
Spinal cord
Run across the shoulders
Under the collarbone
Into the arms
The brachial plexus nerves give the arms their strength and sensation.
When a sideways hit to the head or hit to the shoulder occurs, the nerves can become:
Compressed
Stretched
Irritated
Symptoms of a cervical stinger
This type of sideways collision causes immediate and intense pain, tingling or burning sensations that can run down the arm into the fingers.
Weakness in the affected arm or hand is common.
The weakness, numbness, and tingling sensations can last a few minutes or for a few weeks.
Stinger/burner injury treatment
Fortunately, most stinger injuries heal on their own with rest and relaxation of the neck muscles.
Athletes are placed on the disabled list until symptoms are gone and a doctor has cleared the athlete.
Players can return to sport once the pain is gone and they’ve regained:
Full range of motion
Strength
Normal sensation in neck and arms
Constant or recurring symptoms could indicate a more serious injury.
Cervical x-rays, a CT scan, or MRI could be used to rule out other conditions with similar symptoms.
Can stinger/burner injuries be prevented?
Strengthening exercises for the neck muscles are an important way for athletes and beginners to help prevent these injuries.
Using the proper and correct technique in contact sports to avoid spearing/spear tackles and head down tackling.
Safety equipment, like neck rolls, can help limit the backward movement of the neck.
Players who experience stinger symptoms should immediately report it to their coaches or team/personal physician.
Ignoring or playing through a stinger injury can lead to more severe injuries.
*Neck* Pain Chiropractic Care | El Paso, Tx
Following a balanced diet along with healthy lifestyle habits can help promote optimal health and wellness.
People with neck pain realize how much their symptoms affect their ability to engage in everyday activities.
Dr. Alex Jimenez helps patients achieve neck pain relief through chiropractic care, an alternative treatment option that carefully corrects any spinal misalignments or subluxations.�
NCBI Resources
Stretching is an outstanding complement to chiropractic care.
Blood flow to the muscles is increased, helps lower the risk of injury and improves performance.
Stretching is good for the joints, it helps them function through their full range of motion.
Endocrine disruptors are chemicals that may interfere with the body’s endocrine system and produce adverse developmental, reproductive, neurological, and immune effects in humans. It can be pesticides, plasticizers, antimicrobials, and flame retardants that can be EDCs. EDCs (endocrine-disrupting chemicals) can disrupt the hormonal balance and can result in developmental and reproductive abnormalities in the body.
There are four points about endocrine disruption:
Low dose matters
Wide range of health benefits
Persistence of biological effects
Ubiquitous exposure
EDC can cause significant risks to humans by targeting different organs and systems in the body. The interactions and the mechanisms of toxicity created by EDC and environmental factors can be concerning a person’s general health problems. Including endocrine disturbances in the body since many factors can cause endocrine disruptors, one of the disruptors in the food contaminated with PBDEs (polybrominated diphenyl esters) in fish meat and dairy.
Researchers also pointed out that once the contaminated foods eliminated from a person’s diet, then the endocrine disruptors decline, and the body began to heal properly. When a person eliminates the food that is causing discomfort to their bodies, they are more aware of reading the food labels to prevent discomfort anymore to the body systems.
Obesogen
Obesogen is a subclass of endocrine-disrupting chemicals (EDC) that might predispose individuals to the development of obesity. Their structure is mainly lipophilic, and they can increase fat deposition. Since the fat cell’s primary role is to store and release energy, researchers have found that different obesogenic compounds may have different mechanisms of action.
Some of these actions can affect the number of fat cells that are producing, while others affect the size of the fat cells, and some obesogenic compounds can affect the hormones. These compounds will affect the appetite, satiety, food preferences, and energy metabolism when the endocrine system plays a fundamental role in the body to regulate the metabolism of fats, carbohydrates, and proteins. Any alternations in the body can result in an imbalance in the metabolism and causing endocrine disorders.
Studies even stated that exposure to obesogens could be found either before birth on utero or in the neonatal period. Obesogens can even cause a decrease in male fertility. When this disruption happens to the male body, environmental compounds can cause a predispose to weight gain, and obesogens can appoint as one of the contributors because of their actions as endocrine disruptors. Obesogens can even change the functioning of the male reproductive axis and testicular physiology. The metabolism in the male human body can be pivotal for spermatogenesis due to these changes.
Endocrine Disruptors and Obesity
Some endocrine disruptors that can affect the body can be through pharmaceutical drugs that can cause weight gain. A variety of prescription drugs can have an adverse effect that can result in weight gain since the chemicals found in prescription drugs have similar structures, and modes of action might have a role in obesity. Prescription medicine can stimulate the gut to consume more food, thus involving the body to gain weight.
Another endocrine disruptor is PAHs (polycyclic aromatic hydrocarbons). These are a family of environmental chemicals that occur in oil, coal, and tar deposits. They produce as by-products of fuel-burning like fossil fuel, biomass, cigarette smoke, and diesel exhaust. PAHs can either be manufactured to be used as medicines and pesticides or be released naturally from forest fires and volcanoes.
There are standard ways a person can be exposed to PAHs. One is through eating grilled, charred, or charcoal-broiled meats that a person eats. The other is through inhalation of smoke from cigarettes, vehicle exhaust, or emissions from fossil fuels that can irritate the eyes and breathing passageways in the body.
Coping with EDC Exposure
Even though obesity can adversely affect the body in a variety of health outcomes, there are ways to cope and minimize the exposure of EDC. Research shows that a person can minimize EDC exposure by consuming organic fruits, vegetables, and grain products insofar as possible. This includes an increasing number of fungicides routinely applied to fruits and vegetables that are being identified as obesogens and metabolic disruptors in the body.
Xenoestrogen vs. Phytoestrogen
When a person has an endocrine disorder, it might be due to the food they are consuming. Phytoestrogens are plant-derived compounds that are in a wide variety of food, mostly in soy. They are presented in numerous dietary supplements and widely marketed as a natural alternative to estrogen replacement therapy.
There is a health impact on phytoestrogen, and the plant-derived compound can either mimic, modulate, or disrupt the actions of endogenous estrogen. Xenoestrogen�are synthetically derived chemical agents from certain drugs, pesticides, and industrial by-products that mimic endogenous hormones or can interfere with endocrine disruptors. These chemical compounds can cause an effect on several developmental anomalies to humans. It can also interfere with the production and metabolism of ovarian estrogen in females.
Conclusion
Endocrine disruptors can interfere with the body’s endocrine system causing a health risk to an individual. EDC (endocrine-disrupting chemicals) can target many different organs and systems of the body by various factors that the human body is being exposed to. One of the EDC factors is obesogen, and it can cause a person to gain weight and be obese. Another factor is the exposure of PAHs (polycyclic aromatic hydrocarbons) through environmental factors like smoke inhalation or consuming charcoal-broiled meats. There are ways to cope with EDC exposure, and one is eating organic foods, especially fresh fruits and vegetables. Another is products that target the endocrine system and helps support the liver, intestines, body metabolism, and estrogen metabolism to ensure not only a healthy endocrine system but also a healthy body to function correctly.
October is Chiropractic Health Month. To learn more about it, check out Governor Abbott’s proclamation on our website to get full details on this historic event.
The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or chronic disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .
References:
Cardoso, A M, et al. �Obesogens and Male Fertility.� Obesity Reviews : an Official Journal of the International Association for the Study of Obesity, U.S. National Library of Medicine, Jan. 2017, www.ncbi.nlm.nih.gov/pubmed/27776203.
Darbre, Philippa D. �Endocrine Disruptors and Obesity.� Current Obesity Reports, Springer US, Mar. 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5359373/.
Holtcamp, Wendee. �Obesogens: an Environmental Link to Obesity.� Environmental Health Perspectives, National Institute of Environmental Health Sciences, Feb. 2012, www.ncbi.nlm.nih.gov/pmc/articles/PMC3279464/.
Janesick, Amanda S, and Bruce Blumberg. �Obesogens: an Emerging Threat to Public Health.� American Journal of Obstetrics and Gynecology, U.S. National Library of Medicine, May 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC4851574/.
Janesick, Amanda S, and Bruce Blumberg. �Obesogens: an Emerging Threat to Public Health.� American Journal of Obstetrics and Gynecology, U.S. National Library of Medicine, May 2016, www.ncbi.nlm.nih.gov/pubmed/26829510.
L�r�nd, T, et al. �Hormonal Action of Plant Derived and Anthropogenic Non-Steroidal Estrogenic Compounds: Phytoestrogens and Xenoestrogens.� Current Medicinal Chemistry, U.S. National Library of Medicine, 2010, www.ncbi.nlm.nih.gov/pubmed/20738246.
Patisaul, Heather B, and Wendy Jefferson. �The Pros and Cons of Phytoestrogens.� Frontiers in Neuroendocrinology, U.S. National Library of Medicine, Oct. 2010, www.ncbi.nlm.nih.gov/pmc/articles/PMC3074428/.
Singleton, David W, and Sohaib A Khan. �Xenoestrogen Exposure and Mechanisms of Endocrine Disruption.� Frontiers in Bioscience : a Journal and Virtual Library, U.S. National Library of Medicine, 1 Jan. 2003, www.ncbi.nlm.nih.gov/pubmed/12456297.
Unknown, Unknown. �Endocrine Disruptors.� National Institute of Environmental Health Sciences, U.S. Department of Health and Human Services, 2015, www.niehs.nih.gov/health/topics/agents/endocrine/index.cfm.
Unknown, Unknown. �Polycyclic Aromatic Hydrocarbons (PAHs): Your Environment, Your Health | National Library of Medicine.� U.S. National Library of Medicine, National Institutes of Health, 31 Apr. 2017, toxtown.nlm.nih.gov/chemicals-and-contaminants/polycyclic-aromatic-hydrocarbons-pahs.
Yang, Oneyeol, et al. �Endocrine-Disrupting Chemicals: Review of Toxicological Mechanisms Using Molecular Pathway Analysis.� Journal of Cancer Prevention, Korean Society of Cancer Prevention, 30 Mar. 2015, www.jcpjournal.org/journal/view.html?doi=10.15430%2FJCP.2015.20.1.12.
Over-the-counter or OTC remedies don’t do anything but give some temporary relief, if any at all, but the thing to take away here is that this kind of treatment can exacerbate the issue.
An example of this remedy solution is using store-bought shoe inserts that don’t provide support for the feet and can worsen the condition.
Over the counter, treatment can cost more money in the end, and all this without relief.
These types of insoles are not designed for long-term, daily use. This means they have to be replaced sooner.
Options like wraps and tape also give short-term relief but are not designed to treat the root cause to get rid of it.
Work with a professional to help you get a customized plant like an orthotic insole that will effectively treat the plantar fasciitis and bring long-lasting relief.
Self-Diagnosing & Treatment
This condition can be difficult to identify because of the varying symptoms. Patients could have all or only a few of them.
Symptoms include:
Sharp pain when waking up
Heel spurs
Painful arches
The causes can also vary and include:
Lifestyle
Weight
Age
Gender
Unique composition, shape, and size of the foot
Since it is different for everyone, many try to self-diagnose and do it incorrectly.
Then they try to create their own treatment plans which can be ineffective and dangerous.
Proper treatment requires professional medical attention and not just looking up symptoms online. Treatment is also more than just changing shoes or buying an insole at the local drug or shoe store.
Looking up symptoms and self-diagnosing is not a bad thing, but get a second opinion from a health professional like a chiropractor to make sure that you’re correct and to guide you in obtaining the proper treatment.
Pain Reliever Overuse
Pain relievers are not for treating pain caused by plantar fasciitis.
The convenience of pain relievers like Tylenol and acetaminophen makes it easy to take as soon as the pain kicks in.
The problem is that overuse can be dangerous to the body and can cause:
Kidney problems
Mask symptoms
Disguise other serious issues
Addiction potential�
The best treatment does not require pain relievers.
A professional can help you find relief without pills.
Not Listening to Professional Advice
Trying to schedule a doctor�s appointment can be overwhelming.
Trying to figure out what your insurance covers
Trying to find the time to see a doctor
Finding the right one
Many avoid it altogether and hope the pain goes away.
Many make assumptions about treatment that makes them avoid the doctor,
People have anxiety and are scared of the doctor or what the doctor will find.
There are plenty of excuses for not seeing a qualified professional that specializes in whatever condition you may have.
This is not the case here, the physical therapy or chiropractic care doesn’t go on for weeks or a bunch of follow up appointments.
Relief can be as simple as a customized orthotic insole and an adjustment to the lower back.
Reach out to a chiropractor that can identify, treat and get you moving and pain-free.
Pain and discomfort do not have to be part of normal life.
Saying age or lifestyle is the cause and there’s nothing you can do about it is ridiculous. Remember there are solutions to help prevent and maintain comfort within your body. Give us a call and let us help you live your life pain-free.
Plantar Fasciitis, Reduce *FOOT PAIN* with Custom Orthotics | El Paso, TX (2019)
Gloria Casillas experienced painful symptoms before visiting Dr. Alex Jimenez, a chiropractor in El Paso, TX. Gloria describes how her foot pain gradually developed into plantar fasciitis and how it tremendously affected her quality of life. Gloria Casillas discusses how custom foot orthotics helped her achieve foot pain relief from her plantar fasciitis. Gloria highly recommends Dr. Jimenez as the non-surgical choice for foot pain and plantar fasciitis. Gloria Casillas is grateful for the use of custom foot orthotics.
NCBI Resources
Feet are important. When you consider what your feet go through, taking 8,000 steps over the course of a day, according to the�Illinois Podiatric Medical Association�(IPMA), it�s easy to see how 75 percent of all Americans will have some type of�foot pain�at some point in their lives.�Plantar fasciitis is a common and very painful foot condition that can become chronic if not treated. It is also a condition that responds very well to chiropractic care. Chiropractic adjustments made to the heel and foot take the pressure off of the plantar fascia, allowing it to relax.
Biotransformation is the process of a substance changes from one chemical to another being transformed by a chemical reaction within the body. In the human body though, biotransformation is the process of rendering nonpolar (fat-soluble) compounds to polar (water-soluble) substances so they can be excreted in urine, feces, and sweat. It also serves as an important defense mechanism in the body to eliminate toxic xenobiotics out of the body through the liver. The liver is the one that takes these toxins and transformed them into suitable compounds to excrete out of the body as biotransformation.
Detoxification is also known as �detoxication� in literature. It is also a type of alternative medicine treatment that aims the body to get rid of unspecified �toxins.� It is highly important for a person to detox their body and with biotransformation, it can be classified into two categories, under normal sequences, which tends to react with a xenobiotic. They are called Phase 1 and Phase 2 reactions that help the body with detoxification.
Phase 1 Reactions
Phase 1 reaction is consisting of oxidation-reduction and hydrolysis. Research shows that Phase 1 is generally the first defense employed by the body to biotransform xenobiotics, steroid hormones, and pharmaceuticals. They create CYP450 (cytochrome P450) enzymes and are described as functionalization microsomal membrane-bound that are located in the liver but can also be in enterocytes, kidney, lungs and the brain in the body. The CYP450 enzymes can be beneficial or have consequences for an individual�s response to the effect of a toxin they are exposed to.
Studies have been shown that phase 1 reactions have been affecting the elderly population. It states that hepatic phase 1 reaction involving oxidation, hydrolysis, and reduction appears to be more altered by age since the elderly population comprises the fastest-growing segment of the world�s population. It also states that there is a predictable, age-related decline in cytochrome P-540 function and combined with the polypharmacy that much of the elderly population experiences, this may lead to a toxic reaction of medication.
Phase 2 Reaction
Phase 2 reaction is part of the cellular biotransformation machinery and is a conjugation reaction in the body. They can involve the transfer of a number of hydrophilic compounds to enhanced the metabolites, and the excretion in the bile or urine in the body. The enzymes in Phase 2 reaction can also comprise multiple proteins and subfamilies to play an essential role in eliminating the biotransformed toxins and metabolizing steroid hormones and bilirubin in the body.
Phase 2 enzymes can function not only in the liver but also in other tissues like the small intestines. When it combined with Phase 1, they can help the body naturally detox the toxins that the body may encounter. Hormones, toxins, and drugs undergo a hepatic transformation by Phase 1 and Phase 2 pathways in the liver, then are eliminated by phase 3 pathways.
Xenobiotics
Xenobiotics has been defined as chemicals that undergo metabolism and detoxication to produce numerous metabolites, some of which have the potential to cause unintended effects such as toxicity. They can also block the action of enzymes or receptors used for endogenous metabolism and produce liver damage to a person. Xenobiotics like drugs, chemotherapy, food additives, and environmental pollutants can generate serval free radicals that lead to an increase of oxidative stress in the cells. Accumulation of oxidative stress in the body can lead to an increase in potential cellular reduction in the body.
Research shows that the body has a major challenge when it is detoxifying xenobiotics out of the body system and the body must be able to remove the almost-limitless number of the xenobiotic compounds from the complex mixture of chemicals that are involved in normal metabolism.
Studies even show that if the body doesn�t have a normal metabolism, many xenobiotics would reach toxic concentrations. It can even reach the respiratory tract either through airborne toxins or the bloodstream. It is important to make sure that the body and especially the liver to be healthy. Since the liver is the largest internal organ, it is responsible for detoxifying the toxins out of the body as urine, bile, and sweat.
Conclusion
Biotransformation is the process of substance changes from one chemical to another. In the body, it is a process of rendering fat-soluble compounds to water-soluble compounds, so it can be excreted out of the body as either urine, feces, or sweat. The liver is the one that causes toxic xenobiotics to transform into biotransformation and going through phase 1 and 2 to excrete the toxins out of the body for a healthy function.
Phase 1 reactions in the body are the first line of defense of the body detoxifying itself. Phase 2 creates CYP450 (cytochrome P450) that helps the body take the xenobiotic toxins and oxidates to reduce and hydrolysis the toxins to metabolites. Those metabolites then transform into Phase 2 reactions, which conjugates the metabolites in the body to be excreted out of the body. There are many factors that can make the body have xenobiotics, but the liver is the main organ to detoxify the xenobiotics out of the system. If there is an abundance of xenobiotics in the body, it can cause toxicity reaction causing the body to develop chronic illnesses. These products are known to help support the intestines and liver detoxication as well as, to help support hepatic detoxication for optimal healthy body function.
October is Chiropractic Health Month. To learn more about it, check out Governor Abbott�s bill on our website to get full details.
The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or chronic disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .
References:
Chang, Jyh-Lurn, et al. �UGT1A1 Polymorphism Is Associated with Serum Bilirubin Concentrations in a Randomized, Controlled, Fruit and Vegetable Feeding Trial.� The Journal of Nutrition, U.S. National Library of Medicine, Apr. 2007, www.ncbi.nlm.nih.gov/pubmed/17374650/.
Croom, Edward. �Metabolism of Xenobiotics of Human Environments.� Progress in Molecular Biology and Translational Science, U.S. National Library of Medicine, 2012, www.ncbi.nlm.nih.gov/pubmed/22974737.
Hindawi, Unknown. �Xenobiotics, Oxidative Stress, and Antioxidants.� Xenobiotics, Oxidative Stress, and Antioxidants, 17 Nov. 2017, www.hindawi.com/journals/omcl/si/346976/cfp/.
Hodges, Romilly E, and Deanna M Minich. �Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review with Clinical Application.� Journal of Nutrition and Metabolism, Hindawi Publishing Corporation, 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC4488002/.
Kaye, Alan D, et al. �Pain Management in the Elderly Population: a Review.� The Ochsner Journal, The Academic Division of Ochsner Clinic Foundation, 2010, www.ncbi.nlm.nih.gov/pmc/articles/PMC3096211/.
panelEdwardCroom, Author links open overlay, et al. �Metabolism of Xenobiotics of Human Environments.� ScienceDirect, Academic Press, 11 Sept. 2012, www.sciencedirect.com/science/article/pii/B9780124158139000039.
Sodano, Wayne, and Ron Grisanti. �The Physiology and Biochemistry of Biotransformation/Detoxification.� Functional Medicine University, 2010.
Unknown, Unknown. �ToxTutor – Introduction to Biotransformation.� U.S. National Library of Medicine, National Institutes of Health, 2017, toxtutor.nlm.nih.gov/12-001.html.
Prostaglandins are different than hormones. They are not secreted from a gland that can be carried through the bloodstream and work on specific areas around the body. Prostaglandins are made by a chemical reaction in the body that can be made in all the organs and are part of the body�s way of dealing with injuries and illnesses.
When any part of the body has been damaged, prostaglandins are made at the site of tissue damage or infection where they cause inflammation, pain and fever as part of the body�s healing process. When there is a high level of prostaglandins in the body due to the natural healing process from injuries and inflammation, it can contribute to several diseases from the unwanted inflammation.
Prostaglandins in the Omega fatty acids
In omega-6 fatty acids, DGLA (dihomo-gamma-linolenic acid) creates Prostaglandin E1(PG-1) as anti-inflammatory receptors in the body. In omega-3 fatty acids, they can create Prostaglandin E3 (PG-3) that are also anti-inflammatory receptors as well. PG-1 and PG-3 help prevent blood clotting in the body system.
When it comes to pro-inflammatory receptors, omega-6 fatty acids have these receptors as well. Pro-inflammatory receptors are created by arachidonic acid. Arachidonic acid creates Prostaglandin E2 (PG-2), which is responsible for inflammation, swelling and clotting as well.
There has to be a balance between PG-2 and PG-1,3 to provide a healthy function in the body and an ideal hormone signaling response. When one of the PGs are being disrupted by trans-fatty acids from food, it can cause health problems to a person.
Deficiencies in Prostaglandins
Trans fatty acids are a form of unsaturated fats that can be either natural or artificial. They are produced either by hydrogenation of unsaturated oils or by biohydrogenation in the stomach of ruminant animals. Numerous studies have been shown that consuming trans fatty acids continuously can increase the risk of cardiovascular diseases. This can also increase the ratio of LDL cholesterol to HDL cholesterol in the body. Trans fatty acids can block the activity of D6D (delta-6-desaturase), which is the first step in prostaglandin synthesis from essential fats in the diet.
The excess sugar consumption, insulin surges, inflammation, protein deficiencies hypothyroidism, and alcohol consumption will impair the activity of D6D and be a marker of accelerating aging to the human body. When a person has an increased consumption from fried foods and vegetable oils in an Western diet will shift the omega-6 pathway from PG-1 and into PG-2 production in the body. With the current American diet, people consume a high quantity of omega-6 fatty acids and low quantity of omega-3 fatty acids. This will cause a strong reaction of an inflammatory prostaglandin shift.
Since prostaglandins are caused by injuries and inflammation to heal the body, when an individual consumes a high omega-6 diet, it can cause an excessive amount of inflammation to the body and it can lead to chronic illnesses.
More Deficiencies in Prostaglandins
A deficiency in nutrients like nicotinic acid, pyridoxal 5� -phosphate, calcium, magnesium, zinc, and molybdenum is required for the desaturase and elongase enzymes in omega-6 and omega-3 fatty acids. Their deficiency can lead to improper production of prostaglandins. So EFAs from diets cause overconsumption of omega-6 and a lack of essential fatty acids in the body.
After that happens, then the EFAs can be synthesized into prostaglandins with desaturase and elongase enzymes. This will then cause nutrient deficiencies and metabolic factors can impair and downregulate those enzymes and causing the body to be prone to pro-inflammatory.
When that happens, prostaglandin formation will suddenly turn into abnormal ratios in the body causing problems, excessive inflammation in the endocrine glands and the body organs, and soon later on if it is not fixed, chronic illnesses will cause proper hormones to alter their components and either stop producing or create an abundance in the body.
Conclusion
Prostaglandins are a chemical reaction to the body that are different than hormones. They are caused when the body is injured and it causes inflammation so it can naturally heal itself. When there is an excessive amount of prostaglandins in the body it can lead to chronic inflammation and cause an abnormal shift in the body�s functional state. A factor that can affect the prostaglandins as well is the excessive consumption of omega-6 fatty acids. This consumption can cause inflammation and can make the body feel sluggish and not feeling great. There are products that can help the body, especially balancing the production of essential fatty acids and metabolizing the body for optimal health.
October is Chiropractic Health Month. To learn more about it, check out Governor Abbott�s bill on our website to get full details.
The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or chronic disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .
References:
F.Horrobin, David. �Loss of Delta-6-Desaturase Activity as a Key Factor in Aging.� Medical Hypotheses, Churchill Livingstone, 22 Mar. 2004, www.sciencedirect.com/science/article/abs/pii/0306987781900645.
Horrobin, D F. �Fatty Acid Metabolism in Health and Disease: the Role of Delta-6-Desaturase.� The American Journal of Clinical Nutrition, U.S. National Library of Medicine, May 1993, www.ncbi.nlm.nih.gov/pubmed/8386433.
Innes, Jacqueline K, and Philip C Calder. �Omega-6 Fatty Acids and Inflammation.� Prostaglandins, Leukotrienes, and Essential Fatty Acids, U.S. National Library of Medicine, May 2018, www.ncbi.nlm.nih.gov/pubmed/29610056.
Iqbal, Mohammad Perwaiz. �Trans Fatty Acids – A Risk Factor for Cardiovascular Disease.� Pakistan Journal of Medical Sciences, Professional Medical Publicaitons, Jan. 2014, www.ncbi.nlm.nih.gov/pmc/articles/PMC3955571/.
Leech, Joe. �What Are Trans Fats, and Are They Bad for You?� Healthline, 30 July 2019, www.healthline.com/nutrition/why-trans-fats-are-bad.
Ricciotti, Emanuela, and Garret A FitzGerald. �Prostaglandins and Inflammation.� Arteriosclerosis, Thrombosis, and Vascular Biology, U.S. National Library of Medicine, May 2011, www.ncbi.nlm.nih.gov/pmc/articles/PMC3081099/.
Tallima, Hatem, and Rashika El Ridi. �Arachidonic Acid: Physiological Roles and Potential Health Benefits – A Review.� Journal of Advanced Research, Elsevier, 24 Nov. 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC6052655/.
Unknown, Unknown. �Prostaglandins.� You and Your Hormones, Dec. 2016, www.yourhormones.info/hormones/prostaglandins/.
Wang, Xiaoping, et al. �Multiple Roles of Dihomo-?-Linolenic Acid against Proliferation Diseases.� Lipids in Health and Disease, BioMed Central, 14 Feb. 2012, www.ncbi.nlm.nih.gov/pmc/articles/PMC3295719/.
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