Clinic Wellness Team. A key factor to spine or back pain conditions is staying healthy. Overall wellness involves a balanced diet, appropriate exercise, physical activity, restful sleep, and a healthy lifestyle. The term has been applied in many ways. But overall, the definition is as follows.
It is a conscious, self-directed, and evolving process of achieving full potential. It is multidimensional, bringing together lifestyles both mental/spiritual and the environment in which one lives. It is positive and affirms that what we do is, in fact, correct.
It is an active process where people become aware and make choices towards a more successful lifestyle. This includes how a person contributes to their environment/community. They aim to build healthier living spaces and social networks. It helps in creating a person’s belief systems, values, and a positive world perspective.
Along with this comes the benefits of regular exercise, a healthy diet, personal self-care, and knowing when to seek medical attention. Dr. Jimenez’s message is to work towards being fit, being healthy, and staying aware of our collection of articles, blogs, and videos.
Healthcare professionals commonly give nutritional recommendations based on an entire population, only sometimes changing these according to age, sex, and pregnancy. Over the last 20 years, however, an increase in research studies has demonstrated that epigenetics can ultimately affect nutrition and even increase the risk of developing a variety of health issues, including oxidative stress and inflammation. Recent advances in technology are also currently being used to help healthcare professionals understand how nutrigenomics can affect an individual’s overall health and wellness.
Several research studies have also demonstrated that single nucleotide polymorphisms can explain the risk for individual complex disease traits. A single-nucleotide polymorphism, or SNP, is a substitution of a nucleotide that happens in the genome. Moreover, further research studies can be utilized to explain the variation in health issue risk based on nutrition and genome. The purpose of the following article is to discuss recent developments in the field of epigenetics and personalized nutrition as well as to consider the contribution of research studies to nutritional recommendations.
Understanding Nutrigenomics
Epigenetics is a collection of changes that affect chromatin structure, without altering our DNA sequence, while allowing transcriptional regulation over a range of timescales. Common epigenetic processes include histone modification, non-coding RNAs, and DNA methylation. Many research studies on how epigenetics affects personalized nutrition focus on DNA methylation, however, research findings have demonstrated other epigenetic marks. DNA methylation inside a dinucleotide is a well-known modification in the genome of a variety of mammals in DNA replication and cell division.
Methylation of dinucleotides is shown by DNA methyltransferases, or Dnmts, and is regulated by mitosis. DNA methylation can trigger transcriptional silencing by blocking and/or promoting the connection of transcription factors in the methyl CpG-binding protein MeCP2 which activates histone-modifying complexes to the DNA. MeCP2 activates what is frequently referred to as histone deacetylases, or HDACs, and histone methyltransferases, or HMTs, resulting in a closed chromatin structure and transcriptional silencing. These have been demonstrated to be associated with various health issues.
Dnmt1 is activated by HDACs and HMTs which suggests that chromatin structure may also affect the status of DNA methylation in the regulation of genes associated with nutrition. According to healthcare professionals, epigenetic marks are essentially maintained throughout an individual’s life. However, recent research findings show that epigenetic plasticity can be affected in early development, including in stages of increased physiological changes, such as puberty and aging. This ultimately suggests the possibility that epigenotypes associated with the increased risk of developing health issues can change.
Epigenetics, Personalized Nutrition, and Origins of Health Issues
Research studies have demonstrated that our early life environment can affect our epigenetic process and the origins of health issues. Healthcare professionals also believe that nutrition in our early life can affect our epigeno- and phenotype in the future. Pregnant rat groups given a diet with corn oil resulted in hypermethylation and decreased gene expression in the offspring, causing mature osteoblasts. This is the first research study to find how maternal diet affects epigenetic processes by altering morphogenesis and changing non-imprinted gene expression in pregnant rat groups.
Pregnant rat groups given a diet with an undisclosed type of fat had increased fetal blood glucose concentration and increased mRNA expression of gluconeogenic genes in the fetal liver. A recent research study found that the amount of fat in the maternal diet was one of the major factors resulting in epigenetic changes in the offspring of pregnant rat groups. The diets given to the pregnant rat groups including fat derived from safflower oil, butter, hydrogenated soybean oil, or fish oil caused hypermethylation in the offspring compared with those where pregnant rat groups were only given 7 percent fat.
Furthermore, one research study found that pregnant rat groups given a protein-restricted, or PR, diet developed epigenetic silencing in both histone modifications and DNA methylation which was followed by progressive transcriptional suppression as the offspring aged. The research findings suggest that nutrition during early development can ultimately cause long-term changes in phenotype. Pregnant rat groups given a PR diet also developed hypomethylation of specific dinucleotides in the adipose tissue leptin promoter and in the heart PPARa promoter in adult offspring.
For more information regarding how epigenetics affects personalized nutrition, please review this article:
Healthcare professionals have demonstrated that we can change gene expression and improve the risk of developing a variety of health issues, including oxidative stress and inflammation which can cause chronic pain, by controlling the food we eat. Starting in the kitchen and then taking it to the genes, if we follow a balanced nutrition, we will see a considerable change in our overall health and wellness. We have the ability to assess your specific genetic factors and what dietary guidelines are best for you to follow. One test we use is from DNA life called DNA Diet. A sample of this report is shown below:�
Research studies have demonstrated how epigenetics affect personalized nutrition. The same research studies have also demonstrated that a balanced nutrition can change our gene expression to improve how good food affects our overall health and wellness. While following a proper diet can help improve the risk of developing a variety of health issues, including oxidative stress and inflammation associated with chronic pain, eating good food may be difficult for some people. That’s why drinking smoothies or juices can be easy ways to include the balanced nutrition we need to promote our well-being. In the section below, I’ve provided a smoothie recipe so you can take your health and wellness from the kitchen to your genes. – Dr. Alex Jimenez D.C., C.C.S.T. Insights
Sea Green Smoothie
Servings: 1 Cook time: 5-10 minutes
� 1/2 cup cantaloupe, cubed
� 1/2 banana
� 1 handful of kale or spinach
� 1 handful of Swiss chard
� 1/4 avocado
� 2 teaspoons spirulina powder
� 1 cup water
� 3 or more ice cubes
Blend all ingredients in a high-speed blender until completely smooth and enjoy!
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask�Dr. Alex Jimenez�or contact us at�915-850-0900.
Curated by Dr. Alex Jimenez D.C., C.C.S.T.
References:
KA;, Burdge GC;Hoile SP;Lillycrop. �Epigenetics: Are There Implications for Personalised Nutrition?� Current Opinion in Clinical Nutrition and Metabolic Care, U.S. National Library of Medicine, 15 Sept. 2012, pubmed.ncbi.nlm.nih.gov/22878237/.
PODCAST: Ryan Welage and Alexander Jimenez, both medical students at the National University of Health Sciences, discuss the several new approaches that they developed in order to help people continue to engage and participate in exercise from the comfort of their own homes. Using their advanced understanding of functional medicine, biomechanics, and nutrition, they undertake explaining simple methods and techniques for complex movement protocols. Moreover, Alexander Jimenez and Ryan Welage discuss how diet can be an essential element in overall health and wellness. Dr. Alex Jimenez offers additional guidelines with the Functional Fitness Fellas, among further advice. – Podcast Insight
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Dr. Alex Jimenez RN, DC, MSACP, CCST
Be sure to talk with your provider before taking or combining dietary and herbal supplements with prescription meds or over the counter medications. Individuals with chronic back/neck pain but want to get away from medication/s, and pain relievers, dietary and herbal supplements could be an option. There are dietary supplements as well as, herbal supplements that although used in nutrition, also have added benefits for pain and inflammation relief.
Individuals have found herbs and supplements to be helpful in reducing and alleviating their pain. It is important to understand that these are not a cure-all that will take the pain away or the depression that accompanies chronic spine-related conditions. These are made to help to manage back pain symptoms.
Nutrition and Dietary
A healthy diet includes plenty of fruit, vegetables, and whole grains which keeps the body in top form. Antioxidant foods like green leafy vegetables and berries help in fighting inflammation. Dietary and herbal supplements that research has found helpful in reducing inflammation and pain are listed. However, we must point out that several of these supplements can increase the risk of bleeding. Therefore have a discussion with your health care provider before taking any type of supplement.
Supplements
Omega-3 fatty acids
Flaxseed and Fish Oils
Omega-3 fatty acids can increase the risk of bleeding and conflict with blood-thinning medications like warfarin coumadin and aspirin.
Glucosamine/Chondroitin
Studies show these supplements can help relieve arthritis pain but have not been studied as a treatment for back pain.
Glucosamine and chondroitin can interfere with blood-thinning medications like warfarin coumadin and aspirin.
It can increase the risk of bleeding, so do not take this without consulting a health care provider
It can interact/interfere with antibiotic meds
Do not take if have a peptic ulcer
Herbal Supplements
Herbal supplements have been used by many cultures for health and dietary benefits for a very long time. These supplements are literally made from herbs/plants valued for their flavor, scent, and medicinal qualities. Examples of herbal supplements for pain include:
Cayenne reduces pain signal intensity
Devil’s claw relieves inflammation
Eucalyptus clears chest congestion
Benefits of Herbs
People prefer dietary and herbal supplements instead of standard/traditional drugs and medications for a variety of reasons.
Some because they provide pain relief without the side effects associated with medications. An example is white willow bark, that has been used for years for its anti-inflammatory benefits. And it doesn’t upset the stomach the way medications the way aspirin does.
Some prefer herbal supplements because they are natural.
Herbs come in pill, capsule, tablets, teas, and liquid extracts.
Turmeric
Reduces inflammation and pain
Turmeric can increase the risk of bleeding, especially for those taking blood-thinning medication
Devil’s claw
Reduces pain
Can increase the risk of bleeding and interact with diabetes meds
Can affect the heart and can cause issues for those with gallstones
Willow bark
Relieves pain
Do not take if taking aspirin or blood-thinning meds
Do not take if are allergic to aspirin or salicylates
Do not give to children under eighteen
Capsaicin cream
Reduces pain and inflammation
It is one of the main components in chili peppers
Things to Remember
Dietary and herbal supplements do not have to be approved by the U.S. Food and Drug Administration before they are sold.
Herbs can have medication-like effects on the body
Products sold as dietary supplements and promoted as a treatment, prevention, and/or cure for a disease or condition is considered an unapproved and illegal drug
While dietary supplements and herbal supplements are primarily used to help nutritional needs, these supplements can serve medicinal purposes. Explore alternatives from conventional medications with herbal supplements, as this could be an option. Check with your health care provider before taking supplements if you are pregnant, nursing a baby, or have a chronic medical condition like diabetes, hypertension, or heart disease.
PODCAST: Dr. Alex Jimenez, chiropractor in El Paso, TX, and Victoria Hahn discuss the fasting-mimicking diet and the ProLon Fasting Mimicking Diet program developed by Dr. Valter D. Longo. The ProLon Fasting Mimicking Diet is a high-fat, low-calorie intermittent fasting diet that may promote fat loss and reduce blood sugar, inflammation, and cholesterol, similar to other fasting methods. Valter D. Longo is an Italian-American biogerontologist and cell biologist known for his research studies on the role of fasting and nutrient response genes on cellular protection aging and diseases as well as for proposing that longevity is regulated by similar genes and mechanisms in many eukaryotes. Only a few research studies have been carried out to date regarding the fasting-mimicking diet and more research is needed to validate its benefits. �- Podcast Insight
If you have enjoyed this video and/or we have helped you in any way
please feel free to subscribe and share us.
Thank You & God Bless.
Dr. Alex Jimenez RN, DC, MSACP, CCST
Grains, legumes, and beans, such as kidney beans, lima beans, black beans, soybeans, and lentils, have high amounts of lectins. Other foods with high amounts of lectins include wheat and seeds of the grass family, such as barley, buckwheat, corn, millet, oats, and rye, legumes, including peanuts, and soy, nightshade vegetables, such as peppers, eggplant, and potatoes as well as dairy products, especially those originating from grain-fed animals. In the following article, we will discuss the most harmful lectins.
Most Harmful Lectins to Avoid
Most lectins can trigger inflammation and develop what is known as “advanced glycation end-products. C-reactive protein, by way of instance, is one of many lectins found in the human body that is used as an inflammatory marker. Lectins are considered to be immunotoxic because they can stimulate a hyperimmune response. Lectins are also considered to be neurotoxic and cytotoxic because they can damage nerves and cells, ultimately causing apoptosis or cell death, among other well-known health issues.
Moreover, lectins can increase blood viscosity by attaching to red blood cells. This makes red blood cell “sticky” which can result in abnormal blood clotting. Several lectins, such as WGA, can also affect endocrine function and change gene expression. Lectins may even promote leptin resistance, ultimately increasing the risk of excess weight and obesity. These factors can increase the risk of developing other health issues. If you believe you may have any health issues caused by eating lectins, you may want to avoid:
Corn
Corn-fed meats including most meats sold in grocery stores. Avoid eating factory farmed, corn-fed meat by eating certified grass-fed meat labeled by the American Grass-fed Association.
Cashews, peanuts, and unfermented soybean products. Eat fermented varieties, such as miso, natto, tamari, and tempeh.
Milk with casein A1. Casein A2 is the normal protein found in milk from buffalo, goats, sheep and some Jersey cows. Unfortunately, most cows produce casein A1 and most store-bought milk has casein A1, even if it’s organic. Casein A1 proteins develop beta-casomorphin that can attach to beta cells in the pancreas and result in an autoimmune response. Drink raw milk from organic, grass-fed, casein A2-producing cows. Jersey cows may produce either casein A1 or A2, so make sure to check with the farmer to confirm the type of milk being produced. Avoid milk from Holsteins because they produce casein A1.
How to Make High-Lectin Foods Safe to Eat
After eliminating foods with high amounts of lectins from your diet, you can further decrease lectins in your diet by:�
Peeling and deseeding fruits and vegetables. The skin, or hull, and seeds of many fruits and vegetables have high amounts of lectins. By way of instance, you’ll want to remove the seeds from tomatoes and peppers before eating them.
Choosing white grains over brown grains. Healthcare professionals suggest that white rice is preferable over brown rice because �those who eat rice as their staple grain have always stripped the hull off brown rice before they eat it. That’s because the hull contains all the harmful lectins.� Avoid lectins by choosing organic grains and using yeast or sourdough which effectively breaks down gluten and other harmful lectins.
Sprouting grains, beans, and seeds. Sprouting deactivates lectins although there are several exceptions. Do not sprout legumes. By way of instance, lectins are actually enhanced when sprouting alfalfa.
Eating fermented foods. Fermentation effectively decreases harmful lectins. A wide variety of vegetables can be fermented, ultimately boosting their health benefits.
Using a pressure cooker. The best way to neutralize lectins when cooking is to use a pressure cooker. Healthcare professionals recommend that, �If you’re cooking with beans, tomatoes, potatoes and quinoa, the pressure cooker is your best bet however, it won’t even touch the lectins in wheat, oats, rye, barley or spelt.� Avoid slow cookers since the low cooking temperatures are insufficient to remove lectins.
Tips to Decrease Lectins in Beans and Potatoes
If you choose to eat beans, it’s important to prepare and cook them properly because eating raw or undercooked beans can be harmful towards your overall health. Phytohemagglutinin is a toxin commonly found in many varieties of beans and they are especially high in raw, red kidney beans. According to the U.S. Food and Drug Administration (FDA) eating as few as four or five raw beans may cause phytohemagglutinin toxicity. To decrease lectins in high-lectin foods, consider doing the following including:
Soaking beans in water for at least 12 hours before cooking, making sure to change the water frequently. Adding baking soda to the soaking water will further neutralize lectins in beans.
Discarding the soaking water and rinsing the beans.
Cooking for at least 15 minutes on high heat or using a pressure cooker.
Lectins in potatoes, which are a member of the nightshade family, can also be reduced by cooking, although only by 50 to 60 percent. On a positive note, however, most potatoes have digestive-resistant starch which consists of complex starch molecules that resist digestion in your small intestine. These starches slowly ferment in the large intestine where they act as prebiotics that feed healthy gut bacteria. Because of this, healthcare professionals believe that we should only limit and not eliminate lectins from our diet.
Why You Should Only Limit & Not Eliminate Lectins
Healthcare professionals believe that lectin damage is associated with glyphosate contamination. Scientists make a strong case against lectins due to their potential to be harmful to your overall health. Given the number of foods with high amounts of lectins, however, it would be almost impossible to completely eliminate them from your diet. The list of lectins found in vegetables alone is lengthy and several lectins can actually provide a variety of health benefits if these are consumed in moderation.
Many vegetables with high amounts of lectins also have polyphenols which are micronutrients with antioxidants that play a fundamental role in preventing and reducing the progression of diabetes, heart disease, cancer, and neurodegenerative conditions. Polyphenols are also considered to be prebiotics because they increase the ratio of beneficial bacteria in your gut, which is another important factor for disease prevention and weight management, among providing various other well-known health benefits.
Lectins are proteins in plant- and animal-sources that can be harmful to a person’s overall health because they can attach to cell membranes. Grains, legumes, and beans, such as kidney beans, lima beans, black beans, soybeans, and lentils, have high amounts of lectins. Other foods with high amounts of lectins include wheat and seeds of the grass family, such as barley, buckwheat, corn, millet, oats, and rye, legumes, including peanuts, and soy, nightshade vegetables, such as peppers, eggplant, and potatoes as well as dairy products, especially those originating from grain-fed animals.According to healthcare professionals, eating too many foods with high amounts of lectins can cause nerve damage, lead to cell death, and even promote inflammation while others can change blood viscosity, interrupt endocrine function, and even affect gene expression. However, healthcare professionals argue that eating some foods with lectins can be beneficial as long as these are cooked and consumed properly.�– Dr. Alex Jimenez D.C., C.C.S.T. Insight
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.�
Curated by Dr. Alex Jimenez D.C., C.C.S.T.
References:
1. Bulletproof.com, Revenge of the Beans
2, 9, 17, 18, 22. Precision Nutrition, All About Lectins: Here’s What You Need to Know
3. Healthline April 1, 2015
4. Authority Diet, Dietary Lectins: What Are They and Should You Be Concerned?
5, 8. My Domaine June 25, 2017
6. Krispin.com October 18, 2017
7. Gundry MD May 23, 2017
10. Carbohydrate Research February 1980; 78: 349-363
11. Critical Reviews in Biotechnology 2000; 20(4): 293-334
12. Krispin.com October 18, 2017
13. Superfoodly October 8, 2017
14, 15, 16, 19. Gundry MD May 23, 2017
20, 21. U.S. Food and Drug Administration August 20, 2015
23. Youngmeagher.com, InstaPot Review 2017
24. Today’s Dietitian September 2012; 14(9): 22
Podcast: Metabolic Syndrome Explained
Metabolic syndrome is a collection of risk factors that can ultimately increase the risk of developing a variety of health issues, including heart disease, stroke, and diabetes, among other problems. Central obesity, high blood pressure, high blood sugar, high triglycerides, and low HDL are the 5 risk factors associated with metabolic syndrome. Having at least three of the five risk factors may suggest the presence of metabolic syndrome. Dr. Alex Jimenez and Dr. Mario Ruja explain the 5 risk factors associated with metabolic syndrome, in further detail, as they recommend diet and lifestyle modification advice and guidelines to help people with metabolic syndrome improve their overall health and wellness. From eating fiber and staying hydrated to exercise and better sleep, Dr. Alex Jimenez and Dr. Mario Ruja discuss how diet and lifestyle modifications can help improve the 5 risk factors associated with metabolic syndrome to ultimately prevent the risk of developing a variety of other health issues, including heart disease, stroke, and diabetes. – Podcast Insight
Neural Zoomer Plus for Neurological Disease
Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual�s reactivity to 48 neurological antigens with connections to a variety of neurologically related diseases. The Vibrant Neural ZoomerTM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention.
Food Sensitivity for the IgG & IgA Immune Response
Dr. Alex Jimenez utilizes a series of tests to help evaluate health issues associated with a variety of food sensitivities and intolerances. The Food Sensitivity ZoomerTM is an array of 180 commonly consumed food antigens that offers very specific antibody-to-antigen recognition. This panel measures an individual�s IgG and IgA sensitivity to food antigens. Being able to test IgA antibodies provides additional information to foods that may be causing mucosal damage. Additionally, this test is ideal for patients who might be suffering from delayed reactions to certain foods. Utilizing an antibody-based food sensitivity test can help prioritize the necessary foods to eliminate and create a customized diet plan around the patient�s specific needs.
Gut Zoomer for Small Intestinal Bacterial Overgrowth (SIBO)
Dr. Alex Jimenez utilizes a series of tests to help evaluate gut health associated with small intestinal bacterial overgrowth (SIBO). The Vibrant Gut ZoomerTM offers a report that includes dietary recommendations and other natural supplementation like prebiotics, probiotics, and polyphenols. The gut microbiome is mainly found in the large intestine and it has more than 1000 species of bacteria that play a fundamental role in the human body, from shaping the immune system and affecting the metabolism of nutrients to strengthening the intestinal mucosal barrier (gut-barrier). It is essential to understand how the number of bacteria that symbiotically live in the human gastrointestinal (GI) tract influences gut health because imbalances in the gut microbiome may ultimately lead to gastrointestinal (GI) tract symptoms, skin conditions, autoimmune disorders, immune system imbalances, and multiple inflammatory disorders.
Formulas for Methylation Support
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Proudly,�Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic�Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
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Modern Integrated Medicine
The National University of Health Sciences is an institution that offers a variety of rewarding professions to attendees. Students can practice their passion for helping other people achieve overall health and wellness through the institution’s mission. The National University of Health Sciences prepares students to become leaders in the forefront of modern integrated medicine, including chiropractic care. Students have an opportunity to gain unparalleled experience at the National University of Health Sciences to help restore the natural integrity of the patient and define the future of modern integrated medicine.
That eating sweets does not relieve cravings for sugar?
That you must have sweets after meals?
Hormone imbalances?
If you are experiencing any of these situations, then your blood glucose levels are dramatically fluctuating up and down. It might be an early indication of hyperinsulinemia in your body.
When it comes to the body, many people often try to make sure that their body is healthy and strong by eating the right food, exercising regularly, and even getting a routine check-up from their primary healthcare providers. Even though people can achieve this, sometimes harmful pathogens like autoimmune diseases, metabolic syndrome, and chronic illnesses can affect the body. When harmful pathogens attack the body from the inside, it can cause the body to dysfunction, especially the body’s system. Many people have found ways to dampen the effects that harmful pathogens have caused in their bodies. However, there are some people who are autoimmune compromises or even have diabetes have taken the necessary precautions to make sure that they are in control of their bodies.
It is surprising that when people are controlling their insulin levels, they are accustomed to think that insulin is a blood sugar-regulating hormone. Research shows that when the blood glucose rises in the body, insulin is being secreted in the body to help bring the blood glucose down a bit. This is a partial stimulation known as insulin-sensitive glucose transporters, and this is one of the many roles that insulin provides that are unrelated to the body’s blood glucose. When the blood glucose levels are rising and falling dramatically in the body, it can cause anyone who has diabetes to go into DKA or diabetic ketoacidosis.
Chronic Hyperinsulinemia
Studies have found that when diabetic individuals are keeping an eye on their blood glucose levels, they go on a ketogenic diet to keep their ketones under control. It is a surprise to many people that insulin is not required for cellular glucose uptake. The research study mentioned that when individuals are in a deficient carbohydrate diet, their bodies can regulate and control the production of the ketone bodies, causing a harmless physiological state known as dietary ketosis. The study even mentioned that when ketone bodies are flowing from the liver to the brain, it can be used as fuel. When this happens, spare glucose metabolism is very similar to the mechanism of spare glucose that is oxidizing fatty acids as an alternative fuel.
There is another study that shows that the use of exogenous insulin in individuals who have type 1 diabetes may need to suppress the free glucagon secretion that facilitates glucose transport into their cells. The hormone glucagon has a stimulatory effect on fuel production from the liver and can even modulate the hepatic glucose uptake and the hepatic glycogen synthesis in the body. The study even shows that the hormone glucagon has been longed dismissed as a minor contributor to metabolic diseases in the body. Not only that, but glucagon can even increase hepatic glucose from the liver to the brain and ketone production in the body.
Research on Hyperinsulinemia
What is interesting is that when insulin�s myopic focus is related to blood glucose. Research shows that many people have missed a host of health problems that can occur in the presence of average glucose in the body, but it is known as chronically elevated insulin. The research study showed that when there is a lack of insulin in the liver, it causes glycogenolysis and gluconeogenesis are being activated. When this happens, it can further enhance an overproduction of hormones like glucagon and cortisol, which can stimulate the process of insulin deficiency. A study has found that when a person has chronically elevated insulin or hyperinsulinemia, it can develop cardiometabolic diseases even if elevated glucose is absent. This is due to fasting glucose being part of a routine check-up and chronically elevated glucose.
Studies have shown that chronic hyperinsulinemia is the main factor in POS (polycystic ovarian syndrome) and that there is a high prevalence of undiagnosed insulin resistance with patients who have Parkinson’s disease. Chronic hyperinsulinemia can contribute to insulin resistance, as studies show that this factor can alter lipid metabolism in the body. The research study even shows that insulin sensitivity can be determined by hyper-insulinemic and can lead to weight gain, raised plasma triglycerides, and free fatty acids in the body.
Chronic hyperinsulinemia can be present long before there is a rise in blood glucose. Research shows that there are at least five stages in the progression of diabetes, and it can indicate any metabolic dysfunction that is happening in the body. In one study, it showed that there is an association between hyperinsulinemia in the fasting state and the development of diabetes. The study mentioned that basal hyperinsulinemia in adults who are normoglycemic could constitute an independent risk factor for metabolic deterioration to dysglycemia and can even help identify healthy subjects that may have an increased risk for diabetes.
Conclusion
All in all, if someone wants to make sure that their insulin levels are functioning correctly, they will have to be in a very low-carbohydrate ketogenic diet and keep an eye on their blood glucose levels. Individuals that are living with a condition due to chronic hyperinsulinemia, there are effective ways to manage this condition and even preventing it. Many people should start eating healthy, nutritional food, exercise regularly, and start developing healthy habits in order to achieve an overall sense of health and wellness. Some products are beneficial to regulate blood glucose by providing support to sugar metabolism with hypoallergenic nutrients, enzymatic cofactors, metabolic precursors, and phytonutrients.
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.
References:
Dankner, R, et al. �Basal State Hyperinsulinemia in Healthy Normoglycemic Adults Heralds Dysglycemia After More Than Two Decades of Follow Up.� Diabetes/Metabolism Research and Reviews, U.S. National Library of Medicine, July 2012, pubmed.ncbi.nlm.nih.gov/22865584/.
Hogg, Elliot, et al. �High Prevalence of Undiagnosed Insulin Resistance in Non-Diabetic Subjects With Parkinson’s Disease.� Journal of Parkinson’s Disease, U.S. National Library of Medicine, Feb. 2018, pubmed.ncbi.nlm.nih.gov/29614702/.
Manninen, Anssi H. �Metabolic Effects of the Very-Low-Carbohydrate Diets: Misunderstood �Villains� of Human Metabolism.� Journal of the International Society of Sports Nutrition, BioMed Central, 31 Dec. 2004, www.ncbi.nlm.nih.gov/pmc/articles/PMC2129159/.
Morita, Ippei, et al. �Chronic Hyperinsulinemia Contributes to Insulin Resistance under Dietary Restriction in Association with Altered Lipid Metabolism in Zucker Diabetic Fatty Rats.� American Journal of Physiology. Endocrinology and Metabolism, U.S. National Library of Medicine, 1 Apr. 2017, www.ncbi.nlm.nih.gov/pubmed/28143857.
Sonksen, P., and J. Sonksen. �Insulin: Understanding Its Action in Health and Disease.� British Journal of Anaesthesia, 1 July 2000, bjanaesthesia.org/article/S0007-0912(17)37337-3/fulltext.
Team, DFH. �Hyperinsulinemia: An Early Indicator of Metabolic Dysfunction.� Designs for Health, 12 Mar. 2020, blog.designsforhealth.com/node/1212.
Unger, Roger H, and Alan D Cherrington. �Glucagonocentric Restructuring of Diabetes: a Pathophysiologic and Therapeutic Makeover.� The Journal of Clinical Investigation, American Society for Clinical Investigation, Jan. 2012, www.ncbi.nlm.nih.gov/pmc/articles/PMC3248306/.
Weir, Gordon C, and Susan Bonner-Weir. �Five Stages of Evolving Beta-Cell Dysfunction During Progression to Diabetes.� Diabetes, U.S. National Library of Medicine, Mar. 2004, pubmed.ncbi.nlm.nih.gov/15561905/.
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