We’ve all seen the commercials, web ads, emails, etc�about the best pillow around. Getting a good night’s sleep can be a struggle these days and any type of physical aid is welcome, specifically a pillow. This is especially true of people with chronic, acute cervical neck/back and neuropathic pain.�
Stores carry various lines of pillows that all claim to be the best pillow for neck pain.
With all the different designs out there, choosing the right pillow for your way of sleeping can be a challenge. Dr. Jimenez takes a look at finding the right pillow that will help you sleep, stay asleep and wake up refreshed and with no neck/back pain.
Throughout the sleep cycle, and therefore has a big responsibility. This guide will help you find the right one to meet your sleep needs.
Sleeping position and the pillow can play a major role in comfort or pain.
Example – Stomach sleepers usually have the most neck pain. This is because the neck is turned to the side and the spine is arched.
For relief, try sleeping either on your back or on the side. This along with a pillow that supports the neck and the natural curve of the spine.
Tips for Buying The Right One
These guidelines apply to anyone looking for a pillow that can support the spine. It should:
Keeps your spine naturally aligned meaning the head should rest directly over your shoulders and should not be propped up or pushed back too much
Can be adjusted for maximum support
Supports your head
Eliminates pressure on the cervical spine
Increases sleep duration
Hypoallergenic for those with allergies
Pillows come in all types and sizes, but don�t get it based on how it’s going to look on your bed. Take into account your body size and match that to the size of the pillow.
Picking Based On Your Sleep Position
Picking the right one for you and understanding how you sleep is important, as your sleep position can lead the way.
Stomach sleepers
Thin pillows are the way to go and sometimes not using a pillow at all could be beneficial.
Sleeping on your stomach puts more pressure on the lower back than any other sleeping position. Consider sleeping on your side/back or only sleep on your stomach for short periods then once comfortable switch to the side/back position.
Back sleepers
Thin pillows are also the way to go, but this pillow should have some lift at the bottom to help support your neck.
Memory foam is an option for back sleepers because it adjusts to your�head and neck shape.
Side sleepers
A firm pillow specifically one with a gusset or a piece of material that adds strength and thickness is more structured and can keep your spine aligned.
Specialty�
With severe spine pain or if pregnant, standard pillows do not work. There are specialty pillows that can provide comfort and pain relief.
Chiropractic
Known also as a cervical pillow, these can help if you have chronic neck or back pain that�s not allowing sleep. These are molded to your neck and keep your spine aligned during sleep, and come in a variety of styles and materials. A chiropractor can help you choose the right type and instruct you on how to use it correctly.
Pregnancy
These also come in different types but the aim is to provide support to your growing abdomen. Pregnancy pillows also come with extra body pillows designed to fit under the abdomen and between the knees supporting the entire body.
When To Replace Your Pillow
It is recommended that individuals should replace every 18 months to 2 years depending on how aggressively you sleep.
Using a pillow beyond its lifespan means there is no longer support for your spine which can exacerbate and create new injuries.
How to tell when a pillow is done its duty, fold it in half. If the pillow stays and does not return to the original position is a good indicator that it�s time for a new pillow.
El Paso, TX Neck Pain Chiropractic Treatment
Sleep allows your body to heal and the spine to rejuvenate. It helps you handle stress better and manage pain more effectively. It is an essential part of good health so making sure that you get good quality sleep should be a priority � and it is possible.
NCBI Resources
The�position that you sleep in can help relieve your back pain, but getting good quality sleep will help you manage your pain much better so it should be your goal to get proper sleep every night. And you should change it out on a regular basis.
They can get worn and no longer deliver the support they once did. If you are waking up with neck or back pain or headaches, it could be your pillow. Additionally, studies show that making your bed every day improves your quality of sleep. Make sure that the temperature is comfortable and avoid electronic devices for about an hour before bedtime. Be kind to your spine and make sleep�a priority.
How often do you feel agitated, easily upset, and nervous between meals? How often do you depend on coffee to keep yourself going?How often do you have difficulty concentrating before eating? Inflammation is an essential reaction of the human body. It’s triggered by the immune system to protect us from injury, infection, and/or illness. However, what happens if there is too much inflammation in the human body? And, what happens if there is too much inflammation in the brain?
Neuroinflammation can cause a variety of health issues, such as anxiety, stress, depression, brain fog, fatigue, and even lethargy, among other well-known symptoms. Fortunately, there is one natural remedy that can help tremendously reduce inflammation and improve brain function. According to research studies, curcumin can help combat neuroinflammation. The purpose of the article below is to discuss the anti-inflammatory effects of curcumin in microglia, brain health, and wellness.
Contents
Anti-inflammatory Effects of Curcumin in Microglial Cells
Abstract
Lipoteichoic acid (LTA) induces neuroinflammatory molecules, contributing to the pathogenesis of neurodegenerative diseases. Therefore, suppression of neuroinflammatory molecules could be developed as a therapeutic method. Although previous data supports an immune-modulating effect of curcumin, the underlying signaling pathways are largely unidentified. Here, we investigated curcumin�s anti-neuroinflammatory properties in LTA-stimulated BV-2 microglial cells. Inflammatory cytokine tumor necrosis factor-? [TNF-?, prostaglandin E2 (PGE2), and Nitric Oxide (NO] secretion in LTA-induced microglial cells were inhibited by curcumin. Curcumin also inhibited LTA-induced inducible NO synthases (iNOS) and cyclooxygenase-2 (COX-2) expression. Subsequently, our mechanistic studies revealed that curcumin inhibited LTA-induced phosphorylation of mitogen-activated protein kinase (MAPK) including ERK, p38, Akt, and translocation of NF-?B. Furthermore, curcumin induced hemeoxygenase (HO)-1HO-1 and nuclear factor erythroid 2-related factor 2 (Nrf-2) expression in microglial cells. Inhibition of HO-1 reversed the inhibition effect of HO-1 on inflammatory mediators released in LTA-stimulated microglial cells. Taken together, our results suggest that curcumin could be a potential therapeutic agent for the treatment of neurodegenerative disorders via suppressing neuroinflammatory responses. � Keywords:curcumin, neuroinflammation, TLR2, HO-1, microglial cells
Introduction
Chronic neuroinflammation plays an important role in various neurodegenerative diseases, including AD, Parkinson�s disease (PD), Huntington�s disease (HD), stroke, amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS) (Spangenberg and Green, 2017). Neuroinflammation is interceded by the activation of microglia, the prime effector cells and resident immune cells of the CNS (Nakagawa and Chiba, 2015). Microglial cells can be activated in response to neuronal death or neuronal damage induced by neuroinflammatory responses or by extracellular toxins, such as bacteria and pathogens (Larochelle et al., 2015). In neuroinflammation, activated microglia releases various kinds of cytokines, chemokines, reactive oxygen species, and reactive nitrogen species for the development and maintenance of inflammatory responses (Moss and Bates, 2001). Excessive production of these inflammatory mediators could cause neuronal damage and death. Accumulated evidence suggests that control of microglial activation could attenuate the severity of neurodegenerative disease (Perry et al., 2010). Therefore, the development of anti-neuro-inflammatory agents for the inhibition of microglial activation could be beneficial for the treatment of neurodegenerative diseases.
Microglia express pattern recognition receptors (PRR) that can bind to pattern-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) such as lipopolysaccharide (LPS) and lipoteichoic acid (LTA), respectively (Jack et al., 2005). TLRs, a major class of PRRs, play a crucial role in host defense by inducing innate immune responses. Increasingly, studies have indicated that TLR2 agonist LTA is involved in the pathogenesis of CNS infectious diseases and can induce neuronal damage (Neher et al., 2011). Inhibition of TLR2 activation attenuates microglial cell activation and amyloid ? accumulation in the brain (McDonald et al., 2016; Hossain et al., 2017). Signal transduction via TLR2 is mediated by different adaptor proteins, including MyD88, which promotes downstream signaling via MAPK and NF-?B activation leading to the expression of inflammatory mediators (Larochelle et al., 2015).
Inflammatory and oxidative molecules are very potent activators of Keap-Nrf2 (NF-E2-related factor 2), which induces the expression of Phase II detoxification enzymes to adapt to the oxidative stress condition (Rojo et al., 2010). Usually, Nrf2 acts in an inactive form. Upon stimulation, Nrf2 separates from Keap1 and translocates into the nucleus, where it binds to the antioxidant response element (ARE) to activate the transcription of antioxidant genes for cytoprotection (Ma, 2013; Cho et al., 2015). One of the Nrf2-regulated genes is heme oxygenase-1 (HO-1), which has an ARE sequence in its promoter region. Recently, HO-1 has been reported to be a predominant factor in controlling oxidative stress and inflammatory responses in neurodegenerative diseases (Schipper et al., 2009). HO-1 is the first inducible rate-limiting enzyme in the degradation of heme into by-products. HO-1 may provide neuroprotection or neurotoxic effect because of the balance between the beneficial and toxic effects of heme and heme products (Mancuso et al., 2010). One by-product of HO-1, Bilirubin, has been demonstrated to protect neurons from oxidative stress in vivo and in vitro. Bilirubin can be oxidized to biliverdin by scavenging peroxyl radicals (Chen, 2014). It has been suggested that HO-1, biliverdin, and CO have anti-inflammatory properties (Jazwa and Cuadrado, 2010). Another study has suggested that mice lacking HO-1 were vulnerable to pro-inflammatory stimuli and developed chronic inflammation due to reduced iron levels (Chora et al., 2007). Furthermore, a recent study suggested that the up-regulation of the Nrf2 and HO-1 pathways significantly inhibited the inflammatory reaction in activated microglia (Kim et al., 2016). Nrf2 inhibited microglial hyperactivation by suppressing p38 MAPK and the NF-?B signaling pathway (Kim B.W. et al., 2013). Knockdown of Nrf2 in mice was shown to be hypersensitive to neuroinflammation, as indicated by an increase in the inflammatory markers iNOS, IL-6, and TNF-? (Rojo et al., 2010). Consequently, Nrf2 and HO-1 have been considered as important therapeutic targets for neurodegenerative diseases (Koh et al., 2011; Zhang et al., 2014).
Curcumin, the main curcuminoid isolated from Curcuma longa L. (turmeric) has been used for centuries in Southeast Asia both as a medicinal remedy and as food (Kunnumakkara et al., 2017). Curcumin, demethoxycurcumin, bisdemethoxycurcumin, ar-turmerone, ?-turmerone, and ?-turmerone are the major bioactive compounds found in C. longa. In modern pharmacological studies, C. longa constituents, particularly curcumin, have shown promising pharmacological activities due to its anti-neuroinflammatory, neuroprotective, chemopreventive, immunomodulatory, and potentially chemotherapeutic effects (Garcia-Alloza et al., 2007; Zhou et al., 2017). A previous study showed that curcumin inhibited LPS-induced inflammatory responses in RAW264.7 macrophages, suggesting a potential role of curcumin in anti-Gram-negative bacterial infection (Zhou et al., 2017) and both in vivo and in vitro research have shown that curcumin exhibits anti-inflammatory effects (Garcia-Alloza et al., 2007; Prakobwong et al., 2011; Parada et al., 2015; Li et al., 2016). Furthermore, curcumin has also been reported to promote the development of the M2 microglial phenotype in an HO-1-dependent manner and reduce iNOS induction, protecting microglial cells against oxidative stress (Parada et al., 2015). In the present study, we investigated whether curcumin could affect LTA-induced microglial activation. The TLR2 ligand LTA is a major constituent of the cell wall of Gram-positive bacteria. We show that curcumin exhibits anti-inflammatory and antioxidant effects in LTA-stimulated BV2 microglia through activation of HO-1/Nrf2/ARE cytoprotective mechanisms.
Materials and Methods
Materials
Curcumin and other reagents were purchased from Sigma (C7727, >80%, St. Louis, MO, United States). Protoporphyrin IX (SnPP) and antibodies directed against HO-1 (sc-390991) – Nrf2 (sc-722), TATA-binding protein (TBP; sc-74595), ?-tubulin (sc-134237), and ?-actin (sc-130065) – were purchased from Santa Cruz Biotechnology, Inc., (Dallas, TX, United States). Antibodies directed against iNOS (13120) – phosphorylated (p)-MAPK (9910s), MAPK (9926), protein kinase B (Akt; 4685), p-Akt (13038), and an NF-?B pathway kit (9936) – were purchased from Cell Signaling Technology, Inc., (Danvers, MA, United States). LTA was obtained from InvivoGen (tlrl-pslta,Toulouse, France). Additionally, JNK inhibitor (JNK inhibitor II; 420119), Akt inhibitor (wortmannin; 12-338), ERK inhibitor (PD98059, 513000), and p38 inhibitor (SB230580, 559395) were purchased from EMD Millipore (Billerica, MA, United States). The cell culture medium, DMEM, and fetal bovine serum (FBS) were purchased from Gibco BRL (now Invitrogen Corporation, Carlsbad, CA, United States).
Cell Culture
Mouse BV-2 microglial cells were purchased from ATCC. Cells were cultured in DMEM supplemented with 10% heat-inactivated FBS and 0.1% penicillin-streptomycin (BioSource International, Camarillo, CA, United States) at 37�C in a humidified atmosphere of 5% CO2 and 95% air.
Cell Viability Assay
The cytotoxicity of curcumin was assessed using a microculture [3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (MTT)-based colorimetric assay. Cells were incubated in 24-well plates at a density of 5 � 105 cells per well. The MTT solution (5 ml of 5 mg/ml) was added to each well (final concentration 62.5 mg/ml). After incubation for 3 h at 37�C in 5% CO2, the supernatant was removed and the formazan crystals produced in viable cells were solubilized with 150 ml of dimethylsulfoxide (DMSO). The absorbance of each well was then read at 570 nm using a microplate reader (Wallac 1420; PerkinElmer, Inc., Boston, MA, United States).
Measurement of Nitrite Concentration
NO synthesis in cell cultures was measured by the Griess method with microplate. To measure nitrite, 100-?l aliquots were removed from the conditioned medium and incubated with an equal volume of the Griess reagent [1% sulfanilamide/0.1%N-(1-naphthyl)-ethylenediaminedihydrochloride/2.5% H3PO4] at room temperature for 10 min. The nitrite concentration was determined by measuring the absorbance at 540 nm with a Vmax 96-well microplate spectrophotometer (Molecular Devices, Menlo Park, CA, United States). Sodium nitrite was used as a standard.
Measurement of TNF-? and PGE2 Concentration
The cells were incubated first with various concentrations of curcumin for 1 h and then with LTA for 16 h. Following 24 h incubation, TNF-? and PGE2 levels were quantified in the culture media using an enzyme-linked immunosorbent assay (ELISA) kit (R&D Systems, Minneapolis, MN, United States) according to the manufacturer�s instructions.
Preparation of Nuclear Extract
BV-2 microglial cells were washed three times with cold PBS and collected in 3000 ?l PBS using centrifugation at 800 �g for 5 min (4�C). The cell pellets were suspended in buffer A [10 mM HEPES-KOH (pH 7.9); 1.5 mM MgCl2; 10 mM KCl; 0.5 mM dithiothreitol (DTT); 0.2 mM protease inhibitor (PI)] and incubated for 5 min on ice. Buffer B [10 mM HEPES-KOH (pH 7.9); 1.5 mM MgCl2; 420 mM NaCl; 0.2 mM EDTA; glycerol 25% v/v; 0.1 mM DTT; 0.2 mM PI] was added to the cell extract and was incubated on ice for 5 min prior to centrifugation at 11,000 �g for 1 min at 4�C. Nuclear proteins were extracted with the addition of complete lysis buffer B [10 mM HEPES-KOH (pH 7.9); 1.5 mM MgCl2; 10 mM KCl; 0.5 mM DTT; 0.2 mM PI; 25% (w/v) glycerin; 420 mM NaCl; 0.2 mM EDTA] for 30 min at 4�C with occasional vortexing. Following centrifugation at 11,000 �g for 5 min at 4�C, the supernatants were collected and stored at -70�C.
Western Blot Analysis
BV-2 cells were harvested in an ice-cold lysis buffer (1% Triton X-100; 1% deoxycholate; 0.1% sodium dodecyl sulfate). The protein content of the cell lysates was subsequently determined using Bradford reagent (Bio-Rad Protein Assay Kit I5000001; Bio-Rad Laboratories, Inc., Hercules, CA, United States). Total proteins in each sample (50 ?g) were separated by 7.5% SDS-PAGE and transferred to polyvinylidene difluoride membranes. Following blocking of the non-specific binding sites with 5% non-fat milk at room temperature for 30 min, the membranes were incubated with primary antibodies directed against iNOS (1:500), p-Akt (1:1,000), p-MAPK (1:1,000), MAPK (1:1,000), p-p65, p65 (1:500), p-I?B?, I?B? (1:1,000), HO-1 (1:1,000), Nrf2 (1:1,000), TBP (1:3,000), ? (1:1,000), HO-1 (1:1.0), and actin (1:3,000) for 16 h at 4�C. This was followed by incubation with horseradish peroxidase-conjugated anti-rabbit (sc-2768; 1:5,000) or anti-mouse (sc-2371; 1:5,000) secondary antibodies (Santa Cruz Biotechnology, Inc.) at room temperature for 1 h. Tubulin was used as the loading control for each lane. The proteins were visualized using an enhanced chemiluminescence detection kit (GE Healthcare, Chicago, IL, United States). Following washing with PBS with Tween-20, the protein bands were visualized using the Gel Docsed as the loading control for each lane. The proteins were visualized using a Quant 350 analyzer (GE Healthcare).
Real-Time RT-PCR
Total RNA was isolated from cells using an RNA spin miniRNA isolation kit (GE Healthcare, Uppsala, Sweden) according to the manufacturer�s instructions. cDNA was synthesized from 1 ?g of total RNA using Maxime RT PreMix (Takara, Gyeonggi-do, Japan) and anchored oligo-dT15-primers. Real-time PCR was performed using a Chromo4TM instrument (Bio-Rad) and SYBR Green Master Mix (Applied Biosystems, Foster City, CA, United States). Relative amounts of target mRNA were determined using the comparative threshold (Ct) method by normalizing target mRNA Ct values to those for ?-actin (Ct). Prime sequences used in the study were shown in Table ?1.
Statistical Analysis
Data are expressed as the mean (standard deviation, SD). Each experiment was repeated at least three times. Statistical analysis was performed using the Statistical Package for GraphPad Prism software (version 16.0) to determine significant differences. We used either Student�s t-test or one-way analysis of variance (ANOVA) followed by Dunn�s post hoc tests for analyses. P-values < 0.05 were considered statistically significant.
Results
Curcumin Did Not Affect Cell Viability
Cell viability experiments were carried out to determine whether concentrations of curcumin used in this study affected the viability of BV2 microglia. Figure ?1 shows that curcumin at the concentration range of 5�20 ?M, together with or without 5 ?g/ml LTA, did not produce cytotoxicity in BV2 microglia. Therefore, we used these concentrations of curcumin for further study.
Curcumin Prevented the Production of Neuroinflammatory Molecules in LTA-Activated BV2 Microglia
To investigate the effects of curcumin on the secretion of inflammatory cytokines, BV2 cells were treated with LTA in the presence and absence of curcumin for 24 h. Curcumin was not removed before LTA addition. Release of NO, PGE2, and TNF-? were significantly and dose-dependently reduced by curcumin (Figures 2A�C). Furthermore, LTA increased the mRNA expression of iNOS and COX-2. Incubation with curcumin suppressed the mRNA expression of COX-2 and iNOS in BV2 microglial cells stimulated by LTA in a concentration-dependent manner (Figures 2D, E).
Curcumin Suppressed LTA-Induced Activation of NF-?B in BV-2 Microglial Cells
The genes encoding inflammatory protein expression in response to microglial activation were under the transcription control of NF-?B. Therefore, we examined the effect of curcumin on the activation of NF-?B in LTA-stimulated microglial cells. The results showed that LTA induced a characteristic increase in the phosphorylation of I?B?. Following pre-treatment with curcumin, levels of p-I?B? were significantly reduced in a concentration-dependent manner (Figure ?3 and Supplementary Figure S1). Consistently, the nuclear translocation of the NF-?B p65 subunit induced by LTA was also attenuated by pre-treatment with curcumin. Taken together, curcumin likely attenuates the expression of neuroinflammatory molecules by suppressing the nuclear translocation and activation of NF-?B. Quantification with statistical analysis was provided as supporting data.
Curcumin Inhibited LTA-Induced Activation of p38, and ERK MAPK in BV-2 Microglial Cells
Apart from NF-?B, MAPKs are also upstream modulators of neuroinflammatory molecules in microglial cells. Previous studies showed that curcumin antagonized LPS-induced MAPKs phosphorylation in microphage (Yang et al., 2008; Kunnumakkara et al., 2017). To investigate whether curcumin inhibits neuroinflammation through regulating MAPKs, we examined its effects on LTA-induced MAPK phosphorylation. BV-2 microglial cells were pre-treated with different concentrations of curcumin for 3 h and were then stimulated with LTA for 1 h. As shown in Figure ?4A and Supplementary Figure S2, curcumin inhibited LTA-induced ERK, p38, and Akt phosphorylation. However, up to 20 ?M curcumin did not affect LTA-induced JNK phosphorylation. MAPKs pathway has been reported to mediate the production of cytokines, chemokine, and other neuroinflammatory molecules. Therefore, we next investigated the role of ERK, p38, JNK, and Akt in BV2 cells� neuroinflammatory molecule production using the ERK, p38, JNK, and Akt inhibitors. However, only the p38 inhibitor SB203580 significantly decreased LTA-induced release of NO and mRNA expression levels of iNOS (Figures 4B, C). Although phosphorylation of JNK was not inhibited by curcumin, the JNK inhibitor II significantly inhibited LTA-induced NO release (Figure ?4B). The results suggest that MAPKs� signaling pathways are involved in curcumin�s anti-neuroinflammatory effects in LTA-stimulated microglial. Quantification with statistical analysis is provided as supporting data.
Inhibition of HO-1 Signaling Abolished Curcumin�s Inhibitory Effect on Neuroinflammatory Responses
HO-1 acts as an anti-inflammatory and antioxidant modulator in microglia (Schipper et al., 2009). Western blot and RT-PCR analyses showed that curcumin upregulated HO-1 expression at the protein and mRNA levels, as shown in Figures 5A�D and Supplementary Figure S3. The expression of HO-1 mRNA and protein was maximally increased in BV-2 microglial cells treated with 20?M curcumin for 4 h and 8 h respectively. Furthermore, curcumin increased Nrf2 nuclear translocation within 1 h and prolonged its nuclear translocation state to 2 h (Figures 5E, F and Supplementary Figure S3). Next, we investigated whether curcumin-induced HO-1 mediated an anti-neuroinflammatory response in LTA-stimulated BV-2 microglial cells. We treated cells with the HO-1 inhibitor SnPP. We then evaluated curcumin�s effect on LTA-induced NO and TNF-? release. Treatment with SnPP significantly suppressed curcumin-mediated inhibition of NO and TNF-a release (Figures 5G, H). Taken together, these results reveal that curcumin-dependent HO-1 and Nrf-2 signal activation plays a crucial role in downregulating neuroinflammatory responses. Quantification with statistical analysis is provided as supporting data.
Discussion
Microglia, the major resident macrophages of the CNS, has been reported to be the main effector cells in mediating neuroinflammation and selective neuronal death (Perry et al., 2010). Microglial cells increase the production of neuroinflammatory molecules after exposure to activators such as LPS and LTA via their surface receptors, TLR4 and TLR2, respectively (Perry and Holmes, 2014; Hossain et al., 2017). Increased expression and activation of TLR2 is associated with the progression of neurodegenerative diseases, such as PD and dementia (Dzamko et al., 2017). For example, activation of TLR2 could upregulate ?-synuclein in PD brains and play important roles in the pathogenesis of PD brains (Roodveldt et al., 2013). In addition, Kim C. et al. (2013) also showed that neurodegeneration was attenuated by either knockout or knockdown of TLR2 in rodent PD models. Thus, controlling TLR2-mediated microglia activation and neurotoxicity has been suggested as an important therapeutic approach to treating neurodegenerative diseases. A potential agent in this process could be curcumin, which has been shown to exert neuro-protective and anti-inflammatory effects in various experiment models (Parada et al., 2015; Li et al., 2016). Curcumin is a highly lipophilic natural compound. A previous study has well demonstrated that curcumin is able to cross the blood�brain barrier and that it is mainly concentrated in the hippocampus in the brain (Tsai et al., 2011). Some studies reported that curcumin inhibited HIV-1 gp120-induced neuronal damage and provided anti-neuroinflammatory effects in LPS-induced microglia (Gong et al., 2012). This protective effect of curcumin seems to be dependent on its anti-inflammatory actions. Curcumin could protect neurons against microglia-mediated neurotoxicity while becoming inefficient under microglia-depleted conditions (Park et al., 2001; Yang et al., 2008; Parada et al., 2015). Similar studies in peripheral cells also showed the anti-inflammatory effects of curcumin. Using RAW 264.7 murine macrophages, studies have shown that curcumin inhibited PGE2, NO, and TNF-? release following LPS stimulation (Pae et al., 2008). However, the effects of curcumin on TLR2-induced neuroinflammation in microglial cells are not fully understood.
Regulation of the signaling pathways in activated microglia is important in maintaining CNS homeostasis because deregulated neuroinflammatory responses can result in the death of adjacent neurons through the release of inflammatory molecules, such as cytokines, chemokines, NO, and ROS (Perry and Holmes, 2014; Spangenberg and Green, 2017). For example, excessive NO synthesis under endotoxins results in the formation of reactive nitrogen species and neuronal cell death (Perry et al., 2010). PGE2 has also been shown to contribute to neuronal death through activation of the MAPK/ERK pathway in microglia (Xia et al., 2015). In this present study, we showed that curcumin inhibited the secretion of inflammatory mediators TNF-?, NO, and PGE2, and expression of iNOS and COX-2 in BV2 microglia stimulated with LTA. We further showed that curcumin attenuated these effects of LTA without altering cell survival, suggesting that curcumin is safe and could be considered as a potential therapeutic agent in neuroinflammation.
NF-?B is the main transcription factor which plays critical roles in regulating redox homeostasis. NF-?B is considered the master regulator of microglial inflammatory responses to neuronal injury (Acharyya et al., 2007). Recent studies showed that NF-?B activation controlled the expression of inflammatory molecules, such as NO, PGE2, and TNF-?, and IL-1b production (Acharyya et al., 2007). Therefore, modulation of NF-?B activation is considered a critical way to control microglial activation. The activation of the NF-?B signaling pathway is mediated by the I?B protein. The phosphorylation of I?B results in NF-?B dissociation, which leads to the induction of inflammatory mediators. In this study, it was shown that curcumin produced dual inhibition of phosphorylation and degradation of I?B?, as well as nuclear translocation of p65, suggesting that this agent could stabilize NF-?B in the microglial cytoplasm following stimulation with LTA in BV-2 microglial cells.
In mammalian cells, MAPKs signaling pathways, including ERK, JNK, and p38, contribute to the production of a wide variety of neuroinflammatory mediators (Chantong et al., 2014). In this present study, pre-treatment with curcumin decreased the phosphorylation of p38 and ERK. Furthermore, the p38 inhibitor SB203580 significantly reduced the secretion of NO and the mRNA expression of the key pro-inflammatory gene, iNOS. These results suggested that curcumin initiated the anti-neuroinflammatory effects in LTA-stimulated BV-2 microglial cells, partially through inhibition of p38 MAPK activation. The PI3K/Akt-dependent signaling pathway promotes inflammatory responses in microglia. The involvement of the Akt pathway has been shown in the expression of inflammatory mediators in microglia through the activation of NF-?B in microglia (Lo et al., 2015). Curcumin suppressed the phosphorylated Akt, the downstream target of PI3K. However, the PI3K inhibitor wortmannin did not show any inhibitory effect on the secretion of NO or the mRNA expression of iNOS. Taken together, these data suggest that the anti-neuroinflammatory effect of curcumin occurs mainly through inhibiting the NF-?B and MAPKs signaling.
We also identified the intracellular pathway that negatively regulates the inflammatory-molecule expression in microglial cells. Nrf2 is a redox-sensitive transcription factor that regulates microglial inflammatory responses to brain infections. The effect of Nrf2 has been described in different in vivo models where knockdown of Nrf2 in mice enhanced vulnerability to asthma or emphysema (Ma, 2013). Moreover, the TLR2/TLR4 agonist promoted inflammatory responses in Nrf2 KO mice compared to WT mice (Kong et al., 2011). In the current study, we showed that curcumin increased the expression of Nrf2 and its downstream protein HO-1. HO-1 is a key signaling molecule implicated in the regulation of inflammatory and oxidative responses. The HO-1 gene has an ARE sequence in its promoter region, which is a binding site for the transcription factor Nrf2. Several studies have proposed that NF-?B interrupts the Nrf-2-ARE signaling pathway because many compounds that induced HO-1 and Nrf2 signaling incidentally repressed NF-?B activation (Li et al., 2016). HO-1 expression was essential for the microglial specific cytoprotective effect (Parada et al., 2015). Several studies have also shown an inverse correlation between HO-1 and inflammatory mediator secretion (Chora et al., 2007; Parada et al., 2015). In agreement, we observed that curcumin alone induced the expression of HO-1 in microglial cells. Furthermore, the HO-1 inhibitor abrogated curcumin anti-inflammatory effect in BV-2 microglial cells.
Conclusion
This study demonstrated that curcumin had anti-inflammatory activity in LTA-stimulated microglial cells that may through inhibiting NF-?B and p38 MAPK activation, and may induce the expression of Nrf2 and HO-1 (Figure ?6). Furthermore, curcumin does not have cytotoxic effects in BV-2 microglial cells at its anti-inflammatory dose. Curcumin may have therapeutic potential for some neuroinflammation-associated disorders caused by Gram-positive bacteria.
�
Curcumin, or turmeric, is a powerful anti-inflammatory which has been demonstrated to have many health benefits. Regarded as an antioxidant with anti-cancer, antidepressant, and anti-aging properties, curcumin can do much more than heal wounds and enhance memory. According to research studies, curcumin or turmeric can help reduce neuroinflammation or brain inflammation. This powerful anti-inflammatory can block the production of proinflammatory cytokines and promote overall well-being. – Dr. Alex Jimenez D.C., C.C.S.T. Insight
Neurotransmitter Assessment Form
[wp-embedder-pack width=”100%” height=”1050px” download=”all” download-text=”” attachment_id=”72741″ /]
The following Neurotransmitter Assessment Form can be filled out and presented to Dr. Alex Jimenez. Symptoms listed on this form are not intended to be utilized as a diagnosis of any type of disease, condition, or any other type of health issue.
In honor of Governor Abbott’s proclamation, October is Chiropractic Health Month. Learn more about the proposal.
How often do you feel agitated, easily upset, and nervous between meals? How often do you depend on coffee to keep yourself going?How often do you have difficulty concentrating before eating? Inflammation is an important response of the human body. It’s activated by the immune system to guard us against injury, infection, and/or illness. However, what happens if there is too much inflammation in the human body? And, what happens if there is too much inflammation in the brain?�
Brain inflammation can cause a variety of health issues, such as anxiety, stress, depression, brain fog, fatigue, and even lethargy, among other common symptoms. Fortunately, there is one natural remedy that can help greatly reduce neuroinflammation and improve brain function. According to research studies, curcumin can combat brain inflammation. The purpose of the article above was to discuss the anti-inflammatory effects of curcumin in microglia and brain well-being
The following article has been referenced from the National Center for Biotechnology Information (NCBI). The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .
Curated by Dr. Alex Jimenez
Additional Topic Discussion: Chronic Pain
Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals, however, chronic pain is different than the average type of pain. With chronic pain, the human body will continue sending pain signals to the brain, regardless if the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient’s mobility and it can reduce flexibility, strength, and endurance.
Neural Zoomer Plus for Neurological Disease
Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual�s reactivity to 48 neurological antigens with connections to a variety of neurologically related diseases. The Vibrant Neural ZoomerTM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention.
Formulas for Methylation Support
XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly,�Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic�Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
For your convenience and review of the XYMOGEN products please review the following link. *XYMOGEN-Catalog-Download* All of the above XYMOGEN policies remain strictly in force.
If you are experiencing any of these situations, then try considering intermittent fasting.
Since becoming popular in recent years, intermittent fasting is a dietary approach that lots of individuals have been using in their healthy lifestyle. During the time of the hunter-gatherer society, people have used this method for centuries as a way of survival. Studies have been shown that people used it for medicinal purposes throughout history as a medicinal remedy. Ancient Rome, Greek and Chinese civilizations used intermittent fasting in their daily lives. Fasting has even been used for spiritual reasons in certain religions, like Buddhism, Islam, and Christianity as individuals use it as a way to reflect on themselves and be closer to their deities.
What is Fasting?
Fasting is where a person does not consume food or beverages at least for twelve hours during the day. When a person starts fasting, they will notice that their metabolism and their hormones will change in their bodies. There is upcoming research that intermittent fasting can promote amazing health benefits to the body. The health benefits that intermittent fasting provides are weight loss, protective effects in the brain, decreased inflammation and improving blood glucose and insulin levels in the body.
The Different Methods
There are other methods of fasting that involves fasting from food for several days or weeks. With these different methods, they involve a shorter period that is between 16 to 24 hours. Several types of intermittent fasting are determined by the feeding window duration (when to eat the food) and the fasting window (when to avoid the food). Here are some of the other methods of fasting, which includes:
Time-restricted feeding (TRF): This type of fasting has a feeding window period from 4 to 12 hours. For the remainder of the day, water is the only thing that is allowed to be consumed. The common variation to eat this type of fasting is 16/8. This means that a person has to fast at least 16 hours every day.
Early time-restricted feeding (eTRF): This is a different variety of time-restricted fasting that is from 8 a.m. to 2 p.m. After the 6 hours are up, the rest of the day is made up of this fasting period.
Alternate day fasting (ADF): This type of fasting involves a person eating one day and the next day they completely fast. They alternate between eating and fasting each day to get the benefits.
Period fasting (cycling fasting): This type of fasting involves one or two days fasting per week and for the fifth or sixth days of eating as much as a person desire. The variety of period fasting can be a 5:2 or a 6:1.
Modified fasting: This type of fasting has some methods of intermittent fasting that are similar to alternate-day fasting, but this fasting can be modified for anyone. A person can consume very-low-calorie substances during the fasting window period.
How Does It Work?
Intermittent fasting is the result of changes in the body as the hormone patterns and energy metabolism are being affected. Once a person finishes consuming food, the contents are being broken down and transforming into nutrients, so it can be absorbed into the digestive tract. What happens is that the carbohydrates are broken down and turn into glucose and absorb into the bloodstream, distributing it into the body’s tissue as the essential source of energy. The insulin hormone then helps regulate the blood glucose levels by signaling cells to take the sugars from the blood and turning into fuel for the body to function properly.
With intermittent fasting, a person is done with a meal and their glucose levels are depleted from the body. For the energy to meet its requirements the body has to break down the glycogen that is found in the liver and skeletal muscles causing gluconeogenesis. Gluconeogenesis is when the liver produces glucose sugars from non-carbohydrate sources in the body. Then once the insulin levels are low after 18 hours of fasting, a process called lipolysis begins. What lipolysis does is that the body begins to break down the fat components into free fatty acids. When there is a low quantity of glucose for the body to consume for energy, the body itself with start using fatty acids and ketones for energy. Ketosis is a metabolic state where liver cells start to help fatty acids breakdown and converting them into ketone acetoacetate and beta-hydro butyrate.
The muscle cells and neuron cells use these ketones to generate ATP (adenosine triphosphate) which is the main carrier for energy. Research has stated that the usage and availability of fatty acids combined with ketones as an energy replacement for glucose are beneficial for vital body tissues. This includes the heart, the liver, the pancreas, and the brain.
The four metabolic states are induced by fasting are referred to as the fast-fed cycle, and they are:
The fed state
The post-absorptive state
The fasting state
The starvation state
The physiological effect of intermittent fasting can also be achieved by following a ketogenic diet, which is very high fat and low carbohydrate diet. This diet’s purpose is to shift the body’s metabolic state into ketosis.
The Benefits of Fasting
There are tons of research that have demonstrated how intermittent fasting has a wide variety of health benefits, including:
Weight loss
Type 2 diabetes prevention and management
Improved cardiometabolic risk factors
Cellular cleansing
Decreased inflammation
Neuroprotection
Studies have been shown that several proposed mechanisms are responsible for these health effects of intermittent fasting and have proven to be beneficial to a person’s lifestyle.
Conclusion
Intermittent fasting has been practiced for centuries and has gain popularity in recent years. It involves abstaining from consuming foods for at least 12 consecutive hours by turning the fat cells into energy for the body to function. The health benefits that intermittent fasting provides is beneficial for an individual who is trying to maintain a healthy lifestyle. Some products help provide support to the gastrointestinal system as well as making sure that sugar metabolism is at a healthy level for the body to function.
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.
References:
Dhillon, Kiranjit K. �Biochemistry, Ketogenesis.� StatPearls [Internet]., U.S. National Library of Medicine, 21 Apr. 2019, www.ncbi.nlm.nih.gov/books/NBK493179/#article-36345.
Hue, Louis, and Heinrich Taegtmeyer. �The Randle Cycle Revisited: a New Head for an Old Hat.� American Journal of Physiology. Endocrinology and Metabolism, American Physiological Society, Sept. 2009, www.ncbi.nlm.nih.gov/pmc/articles/PMC2739696/.
Stockman, Mary-Catherine, et al. �Intermittent Fasting: Is the Wait Worth the Weight?� Current Obesity Reports, U.S. National Library of Medicine, June 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC5959807/.
Zubrzycki, A, et al. �The Role of Low-Calorie Diets and Intermittent Fasting in the Treatment of Obesity and Type-2 Diabetes.� Journal of Physiology and Pharmacology: an Official Journal of the Polish Physiological Society, U.S. National Library of Medicine, Oct. 2018, www.ncbi.nlm.nih.gov/pubmed/30683819.
In today’s busy world individuals need a little help when it comes to letting go of bad/negative behaviors and adopting/embracing positive behaviors to sustain optimal health and lifestyle. This is where a health coach�comes in.
More adults in the United States have a chronic disease and around thirty percent have two or more.
Many healthcare professionals do not know how to counsel patients on healthy living and, if they do, the information is limited to very basic knowledge like exercise and eat healthily. With this type of info and not a lot of enthusiasm, patients are not going to listen or make lasting changes.
Many providers do not listen to what’s going on and just tell patients what to do, instead of discussing the best options they have for their health. People being told what to do are not likely to listen or act upon the recommendations.
A health coach creates a custom getting healthy plan with you that fits your life, gets you going, sets up a strategy for the challenges and sees you through! This is what a health coach does.
Contents
Health coaching Involves
Communication
Motivation
Continued Support
This allows individuals to make meaningful behavior changes that will last forever.
Coaching centers on:
Thorough conversation
Listening
Clinical Intervention
Strategies
These are aimed to actively engage patients in positive behavior change.
Health coaches take on patients wherever they are in their health. An individual can be healthy and just want some advice to individuals that are extremely unhealthy with weight issues, chronic illness, disease or all of the above.
The point is to help individuals learn self-management techniques. The coach teaches, motivates and strategizes with the individual to make educated/informed decisions that will turn into regular healthy habits.
Coaching comes in the form of:
Setting�goals that are achievable�
A Patient’s Values
Strengths
Motivation
Encouraging the patient
This is how healthy attitudes and behaviors are developed.
The Health Journey Begins
The patient’s health history is taken into account. Then the coach asks:
Where they want to be in their health
What Values they hold close
What Goals they have in mind
The plan is Created
Progress is Tracked
Challenges are met
The long-term plan is Created
Patients oftentimes do not know where they are from a health perspective and might not be sure how to explain. This is where health coaches and their training can breakdown any questions/issues a patient may have.
A health coach will look at where a patient is healthwise based on:
Emotional factors
Environmental factors
Financial factors
Psychological factors
Physical factors
Recreational factors
Spiritual factors
Social factors
This health inventory is for the patient to reflect on where they are in their health and where they want to be.
Patients are welcome and encouraged to ask questions about the plan, make changes, reset goals, etc.
Motivating the Patient
Motivation can come in various forms. As people learn in various ways, so too are the motivational strategies to get patients to exercise the positive behavior outlined in their treatment plan. Some ways coaches motivate are:
They collaborate with patients and don’t approach the plan with an all-knowing mindset.
Understand the motivation of the individual to change.
Motivational Principles:
Empathy
Discrepancy
Support patient’s ability
Six stages of behavioral change:
Precontemplation – Patients do not see any problems and do not consider their behavior as negative, and do not see the problems their behavior is causing.
Contemplation – Patients start to think about healthy behaviors.
Preparation/Determination�– Patients are ready to take action toward behavior change and believe the new behavior will lead to a healthy life.
Action�– Change begins and the intention is to keep going.
Maintenance – Behavior change has been for more than six months and continuing on the right track.
Termination�– Negative behaviors are eliminated.
There are different strategies to get through each stage and on to the next until the positive behavior is achieved.
Helping the patient find the coaching plan that is right for them.
Patients are helped by figuring out what they want to change about their health based on what they see and
the most important changes for them. There is no correct answer, as it is different for everyone.
Understanding Your Values
Coaches encourage the patient to identify their values, and what is most important for each individual.
These include:
Family
Friendship
Health
Love
Values begin early in childhood and become reevaluated as life goes on, and can change.
Clarity is important to help the patient build self-awareness to make intelligent decisions and staying balanced.
A coach might ask questions like:
What made you choose the unhealthy product versus the healthy version?
How much stress do you think you have to deal with on a daily basis?
Do you make time for yourself?
For some, identifying negative behavior can help, as the patient grows and realizes how their health is changing, their values start to change.
This information helps to create a plan of action along with steps to help the patient’s decision making.
While working with the patient to determine goals and create steps, tools and methods are created help to ensure the patient understands their role in getting healthy.
Asking Questions
Coaches ask patients what they know and what they would like to know?�There are no incorrect questions, aks away, as the more an individual knows, as well as the more that the coach knows about the patient, the better the treatment plan will be.
Teaching
If the patient doesn�t understand, the process is repeated until the patient is able to explain the treatment plan back to the coach so everything is clear.
This technique is recognized by various associations, including the:
American Academy of Family Physicians
American Hospital Association
Primary Areas of Improvement
Before setting goals the patients go over the primary areas of their life that they want to improve/change.
These primary areas may be very similar to the patient�s values.
Examples include:
Health
Family
Career
Finances
Recreation
Social Relationships
Once a patient has identified what they would like to focus on, brainstorming sessions are put into action, as to what they want to change or improve for each primary area.
They are then broken down into smaller goals in the creation of the main plan of action.
As the patient moves forward they are more motivated and encouraged to take on bigger challenges.
Couple making a healthy smoothie
Goals
Patients understand what areas of their life they want to improve/change.
With the primary areas known, the patient begins the challenge of changing their current unhealthy status to healthy.
Areas to consider:
What exactly do I want to achieve?
How will I achieve this goal?
Timeframe to achieve this goal?
Why is this goal important to me?
Where to go to next once the goal is achieved?
SMART Goals
When the patient is ready, the coach will assist in developing:
Specific
Measurable
Attainable
Relevant
Timely
SMART goals that allow for structure and trackability and create clear milestones for the individual.
Planning
Once a health coach understands where the patient wants to go, the next phase is planning.
Patients help in creating their treatment plan.
This plan is an agreement between the patient and the health coach that describes the behavior change that the patient wants to make, how they’re going to go about it, and their commitment to the final result.
Example of goals a patient will follow to lose weight:
Try new fruits and vegetables
Find creative ways to incorporate exercise at work.
Stay hydrated by keeping a water bottle and refilling it every two hours.
Cooking healthy meals at first twice a week then three times and so on.
Walking after meals.
These small tasks make it easier for the patient to see their progress.
The coach will check with the patient regularly to make sure they are sticking to the plan.
Health Coach
Goal Progress
Health coaches can ensure a patient has consistent motivational support by creating a follow-up plan that works in conjunction with their primary treatment plan.
Follow-up care may include schedules for physical exams or tests, referrals, and recommendations to keep positive behavior development.
Coaches and patients work together to create realistic goals for the future.
As the patient progresses, the health coach may make additional recommendations or work with the patient to adjust their plan or making sure the patient knows where to turn to if they have questions.
Continued Support
Once goals are being achieved it is important to have support to continue the positive behavior. Traditional sources of support include:
Family
Friends
Colleagues
Community
Patients may not always have access to external support, coaches also teach the patients how to find positive support in various activities around town that can help patients and their overall health.
At Injury Medical Chiropractic & Functional Wellness clinic we have the best-rated team of health practitioners to get you to your best optimal health.
*Detox Your Body* | Detox Doctor | El Paso, TX (2019)
Fred Foreman is a basketball coach who depends on his overall health and wellness to be able to engage in his everyday responsibilities. As a result, coach Foreman started the 6 Day Detox Program, designed to help renew and enhance the human body’s cleansing and detoxification capabilities.
NCBI Resources
Good health is built on diet and exercise. The goal is to continually improve by maintaining healthy habits that develop more healthy behaviors. You do not have to do anything drastic. You will have an easier time making changes if you start small and gradually shift towards a lifestyle that is best for you. A health coach can get you operating and performing at the highest level!
How high is your stress level? How often do you feel overwhelmed? Anxiety is a well-known health issue that is, unfortunately, often misunderstood, especially when it manifests other misunderstood symptoms like brain fog. � Brain fog is commonly associated with reduced thinking and processing while anxiety is frequently associated with racing thoughts that can make people overly cautious as well as worries that can keep people awake, wired, and restless. How does anxiety cause brain fog? The purpose of the following article is to understand brain fog associated with anxiety. �
Contents
How Does Brain Fog with Anxiety Happen?
Brain fog is a symptom rather than a single health issue. It�s described as the sensation that your brain isn’t functioning properly. Anxiety involves symptoms of overthinking, excessive worrying, imagining negative outcomes, and fear. � Brain fog and anxiety happens because the symptoms of one health issue can ultimately cause the symptoms of the other health issue and vice versa. This can also worsen both conditions. Brain fog and anxiety can cause an infinite loop. �
Anxiety involves �what-ifs,� ruminations, and negative thinking
This can then lead to mental exhaustion or fatigue
Fatigue can also develop brain fog
Brain fog can in turn increase anxiety because it feels frightening, worrisome
Increased anxiety causes this cycle to repeat, seemingly endlessly
Brain fog associated with anxiety may vary from person to person. Several people will experience it often while others will experience it less frequently. It can also come and go quickly, or it can ultimately last for days, weeks, and even months. � Evaluating the symptoms and the causes of brain fog and anxiety will provide insights that can be used for treatment. �
Symptoms of Brain Fog with Anxiety
Brain fog and anxiety share a common symptom, frequently referred to as fatigue or tiredness. Brain fog, anxiety, and fatigue are well-known symptoms that are often connected. However, fatigue is believed to be at the heart of brain fog and anxiety. � Anxiety appears to take control of our entire brain and aggravates thoughts, emotions, and behaviors. Living in a state of constant anxiety is exhausting. Moreover, anxiety can cause sleeping problems. Fatigue can lead directly to brain fog. � Common symptoms of brain fog, anxiety, and fatigue can ultimately include: �
Difficulty concentrating and focusing
Muddled, unclear thoughts
Short-term memory problems
Difficulty reasoning logically
Trouble processing, storing, and retrieving information
Living in a fog that makes grasping comments, instructions, and conversations challenging
The vague sense that you just feel �off� but can�t do anything about it
Causes of Brain Fog with Anxiety
The brain fog that occurs with anxiety can have several causes, including: �
The�symptoms of anxiety, as previously discussed above
The brain�s mental, physical, and emotional response to anxiety
Stress as well as stress hormones and other substances or chemicals.
Understanding the cause of brain fog with anxiety can increase awareness of why these health issues can develop. � The brain�s own reaction to anxiety can also make it feel tired and foggy. The fight-or-flight response is an automatic fear response. The brain reacts in response to an extreme stressor to prepare to either stay and fight or run away to safety. �
Activity in the cortex, the area of rational thinking, decreases, which leads to the inability to think properly
Activity in the hippocampus, the area responsible for learning and memory, is suppressed, causing confusion
Activity in the amygdala accelerates to keep you hypervigilant and ready to leap before you look
The brain also controls the production of hormones in reaction to stress and anxiety. Cortisol, adrenaline, and norepinephrine travel through the brain and the body to keep you alert and ready for action but when these hormones are triggered for too long or in quantities that are too high, they overwhelm and exhaust the brain, causing brain fog. �
Treatment for Brain Fog and Anxiety
The best treatment for brain fog associated with anxiety is to treat it at its source. It’s essential to understand the symptoms of both brain fog and anxiety as well as take steps to reduce other symptoms like fatigue. Furthermore, know what is causing your symptoms so you can ultimately make positive changes to reduce them or even eliminate them, including: �
Develop stress management strategies
Take measures to increase the amount and quality of sleep
Address your anxiety, either with a therapist or other qualified healthcare professional
Listen to your body and brain; participate and engage in exercise, yoga, mindfulness, and meditation
� Brain fog and anxiety can be difficult. But by actively working on them, you can reduce both and promote overall well-being. �
Anxiety can commonly cause a variety of symptoms, including brain fog. Although it may seem like brain fog and anxiety are two separate as well as different health issues, they are frequently connected. Both anxiety and brain fog can cause concentration, focus, and memory problems, and stress is considered to be one of the most well-known causes of brain fog associated with anxiety. Treatment for anxiety and brain fog often involves treating the underlying source of the health issues. – Dr. Alex Jimenez D.C., C.C.S.T. Insight
Neurotransmitter Assessment Form
The following Neurotransmitter Assessment Form can be filled out and presented to Dr. Alex Jimenez. Symptoms listed on this form are not intended to be utilized as a diagnosis of any type of disease, condition, or any other type of health issue. �
In honor of Governor Abbott’s proclamation, October is Chiropractic Health Month. Learn more about the proposal. �
How high is your stress level? How often do you feel overwhelmed? Anxiety is a well-known health issue that is, unfortunately, often misunderstood, especially when it manifests other misunderstood symptoms like brain fog. � Brain fog is commonly associated with reduced thinking and processing while anxiety is frequently associated with racing thoughts that can make people overly cautious as well as worries that can keep people awake, wired, and restless. How does anxiety cause brain fog? The purpose of the following article is to understand brain fog associated with anxiety. �
The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 . �
Curated by Dr. Alex Jimenez �
Additional Topic Discussion: Chronic Pain
Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals, however, chronic pain is different than the average type of pain. With chronic pain, the human body will continue sending pain signals to the brain, regardless if the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient’s mobility and it can reduce flexibility, strength, and endurance.
Neural Zoomer Plus for Neurological Disease
Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual�s reactivity to 48 neurological antigens with connections to a variety of neurologically related diseases. The Vibrant Neural ZoomerTM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention. �
Formulas for Methylation Support
XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly,�Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic�Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
�
For your convenience and review of the XYMOGEN products please review the following link. *XYMOGEN-Catalog-Download �
* All of the above XYMOGEN policies remain strictly in force.
Like you have been diagnosed with Celiac Disease, Irritable Bowel Syndrome, Diverticulosis/Diverticulitis, or Leaky Gut Syndrome?
Excessive belching, burping, or bloating?
Abnormal distention after certain probiotics or natural supplements?
Suspicion of nutritional malabsorption?
Do digestive problems subside with relaxation?
If you are experiencing any of these situations, then you might be experiencing gut problems and might have to try the 4R Program.
Food sensitivities, rheumatoid arthritis, and anxiety have been associated with impaired gastrointestinal permeability. These various conditions can happen from many factors that can impact the digestive tract. If left untreated it can potentially be the result of dysfunction of the intestinal permeability barrier, causing inflammation, and severe health conditions that the gut can develop. The 4R program is used to restore a healthy gut in the body and involves four steps. They are: remove, replace, reinoculated, and repair.
Intestinal Permeability
The intestinal permeability helps protects the body and makes sure that harmful bacteria do not enter the gut. It protects the body from potential environmental factors that can be harmful and are entering through the digestive tract. It can be either toxin, pathogenic microorganisms, and other antigens that can harm the digestive tract causing problems. The intestinal lining is consisting of a layer of epithelial cells that are separated by tight junctions. In a healthy gut, the tight junction regulates the intestinal permeability by selectively allowing substances to enter and travel across the intestinal barrier and preventing harmful factors from being absorbed.
Certain environmental factors can damage the tight junction, and the result is that it can increase the intestinal permeability, which causes intestinal hyperpermeability or leaky gut in the body. Contributing factors can increase intestinal permeability like an excessive amount of saturated fats and alcohol, deficiencies in nutrients, chronic stress, and infectious diseases.
With an increased intestinal permeability in the gut, it can enable antigens to cross the gut mucosa and enter the bloodstream causing an immune response and inflammation to the body. There are certain gastrointestinal conditions that are associated with intestinal hyperpermeability and if left untreated it can trigger certain autoimmune conditions that can cause harm to the body.
4Rs Program
The 4Rs is a program that healthcare professionals advise their patients to use when they are addressing disruptive digestive issues and help support gut healing.
Removing the Problem
The first step in the 4Rs program is to remove harmful pathogens and inflammation triggers that are associated with increased intestinal permeability. Triggers like stress and chronic alcohol consumption can do much harm to an individual’s body. So targeting these harmful factors from the body is to treat it with medication, antibiotics, supplements, and the removal of inflammatory foods from the diet is advised, including:
– Alcohol
– Gluten
– Food additives
– Starches
– Certain fatty acids
– Certain foods that a person is sensitive to
Replacing the Nutrients
The second step of the 4Rs program is to replace the nutrients that are causing the gut problems through inflammation. Certain nutrients can help reducing inflammation in the gut while making sure that the digestive tract is being supported. There are some anti-inflammatory foods that are nutritious. These include:
– High-fiber foods
– Omega-3s
– Olive oil
– Mushrooms
– Anti-inflammatory herbs
There are certain supplements can be used to support digestive function by assisting and absorbing the nutrients to promote a healthy gut. What the digestive enzymes do is that they assist in helping to break down fats, proteins, and carbohydrates in the gut. This will help benefit individuals that have an impaired digestive tract, food intolerances, or having celiac disease. Supplements like bile acid supplements can help assist in nutrient absorption by merging lipids together. Studies have stated that bile acids have been used to treat the liver, gallbladder, and bile duct while preventing gallstone formation after bariatric surgery.
Reinoculated The Gut
The third step is of the 4rs program to reinoculated the gut microbe with beneficial bacteria to promote a healthy gut function. Studies have been shown that probiotic supplements have been used to improve the gut by restoring beneficial bacteria. With these supplements, they provide the gut an enhancement by secreting anti-inflammatory substances into the body, help support the immune system, altering the body’s microbial composition, and reducing the intestinal permeability in the gut system.
Since probiotics are found in fermented foods and are considered as a transient since they are not persistent in the gastrointestinal tract and are beneficial. Surprisingly, they still have an impact on human health due to influencing the gut by producing vitamins and anti-microbial compounds, thus providing diversity and gut function.
Repairing the Gut
The last step of the 4Rs program is to repair the gut. This step involves repairing the intestinal lining of the gut with specific nutrients and herbs. These herbs and supplements can help decrease intestinal permeability and inflammation in the body. Some of these herbs and supplements include:
– Aloe vera
– Chios mastic gum
– DGL (Deglycyrrhizinated licorice)
– Marshmallow root
– L-glutamine
– Omega-3s
� Polyphenols
– Vitamin D
– Zinc
Conclusion
Since many factors can adversely affect the digestive system in a harmful way and can be the contributor to several health conditions. The main goal of the 4Rs program is to minimize these factors that are harming the gut and reducing inflammation and increased intestinal permeability. When the patient is being introduced to the beneficial factors that the 4Rs provide, it can lead to a healthy, healed gut. Some products are here to help support the gastrointestinal system by supporting the intestines, improving the sugar metabolism, and targeting the amino acids that are intended to support the intestines.
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.
References:
De Santis, Stefania, et al. �Nutritional Keys for Intestinal Barrier Modulation.� Frontiers in Immunology, Frontiers Media S.A., 7 Dec. 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC4670985/.
Ianiro, Gianluca, et al. �Digestive Enzyme Supplementation in Gastrointestinal Diseases.� Current Drug Metabolism, Bentham Science Publishers, 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC4923703/.
Mu, Qinghui, et al. �Leaky Gut As a Danger Signal for Autoimmune Diseases.� Frontiers, Frontiers, 5 May 2017, www.frontiersin.org/articles/10.3389/fimmu.2017.00598/full.
Rezac, Shannon, et al. �Fermented Foods as a Dietary Source of Live Organisms.� Frontiers in Microbiology, Frontiers Media S.A., 24 Aug. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6117398/.
Sander, Guy R., et al. �Rapid Disruption of Intestinal Barrier Function by Gliadin Involves Altered Expression of Apical Junctional Proteins.� FEBS Press, John Wiley & Sons, Ltd, 8 Aug. 2005, febs.onlinelibrary.wiley.com/doi/full/10.1016/j.febslet.2005.07.066.
Sartor, R Balfour. �Therapeutic Manipulation of the Enteric Microflora in Inflammatory Bowel Diseases: Antibiotics, Probiotics, and Prebiotics.� Gastroenterology, U.S. National Library of Medicine, May 2004, www.ncbi.nlm.nih.gov/pubmed/15168372.
How often do you feel you have something that must be done? How often do you have difficulty concentrating before eating? Do you suffer from headaches and/or migraines? Head pain is commonly characterized by a variety of symptoms, including pain and discomfort, photophobia or light sensitivity, dizziness, lethargy, and mood changes. However, one of the most common symptoms of head pain is brain fog, which also causes its own variety of symptoms. In the following article, we will discuss brain fog associated with head pain and pressure as well as the common cause of brain fog and headache/migraine. �
�
�
Many patients will commonly visit healthcare professionals reporting mild or moderate head pain and pressure as well as a variety of other symptoms, such as brain fog, fatigue, and even vision problems, among others.� The patients frequently experience a “constant cloud” over their brain and they generally never have a clear head or mental clarity. Many patients will commonly report numerous other symptoms, including poor short-term memory, detachment from reality, sharp pain and discomfort in the head, and ringing in the ears. Many others report anxiety, caused or worsened by the symptoms. �
�
�
Contents
Brain Fog and Head Pain
The first approach towards characterizing brain fog associated with head pain is to make sure it’s not caused by a secondary headache or a headache with an identifiable cause. Several types of head pain are more severe than others, such as giant cell arteritis or inflammation of the arteries that run along the temples, raised blood pressure or hypertension,�brain hemorrhage, brain infections like encephalitis, increased pressure in the fluid of the brain or raised intracranial pressure, and brain tumors. Less severe types of head pain include�carbon monoxide poisoning, taking too many painkillers or medication-overuse headache, disorders of the joints of the jaw or temporomandibular joint disorders, dental problems, and sinus infections or sinusitis. Below, we will discuss several of the most common causes of brain fog associated with head pain.
�
Causes of Brain Fog and Head Pain
Researchers and healthcare professionals have offered their own hypotheses for why brain fog occurs with head pain, based on their own knowledge and experiences. They believe that brain fog and head pain occur due to epilepsy, overactive parathyroid glands or hyperparathyroidism, overactive thyroid gland or thyrotoxicosis, and brain circulation problems. Researchers and healthcare professionals also suggest it could be due to a vitamin B12 deficiency. Fortunately, the utilization of CT and MRI brain scans, heart tracing, EEG and blood tests, can be utilized to rule out many of these health issues.
Moreover, several health issues require specific tests and evaluations. These include tests for lupus or an inflammatory disorder, magnesium deficiency, zinc deficiency,�Lyme disease or an infection resulting from a tick bite, and postural tachycardia syndrome or an increase in heart rate on standing. Many researchers and healthcare professionals also recommend a detailed examination and investigation of a misalignment or subluxation of the neck or cervical spine. �
If all these tests and evaluations return as normal, then the next approach towards characterizing brain fog associated with head pain is to make sure it’s not caused by a primary headache or a headache without an underlying secondary cause. Primary headaches are diagnosed in 9 out of 10 cases of head pain and pressure. The most common types of primary headaches include tension-type headache,�migraine, and daily persistent headache. Diagnosis depends on the pattern of symptoms as well as examinations and investigations to rule out underlying causes. Although there are specific treatment options for several primary headaches like migraines, in many instances, treatment is frequently a matter of trial and error. �
Furthermore, despite the best efforts of researchers and healthcare professionals as well as comprehensive examinations and investigations, many people who suffer from brain fog associated with head pain and pressure are still left without any explanation for their symptoms. Researchers and healthcare professionals have a name even for this type of brain fog-related head pain known as medically unexplained symptoms or MUS. This ultimately means exactly what reads as: no one is denying that the person has the symptoms, but doctors have been unable to find a medical condition to explain them. �
Several people with MUS undoubtedly do have stress, anxiety, and even depression whether as a result of the symptoms or as a cause of the symptoms. Researchers and healthcare professionals recommend continuing to pursue psychological support if you have brain fog and head pain, as this may help to relieve a potential cause as well as helping to cope with the symptoms. Cognitive-behavioral therapy�would be ideal for this purpose, as would�mindful awareness, a technique that would arm people with a way of deflecting their mind away from their troubling symptoms, improving overall well-being. �
Brain fog can make people feel as if they’re not able to focus or concentrate accordingly and it’s commonly accompanied by head pain, fatigue and even vision problems. While brain fog is a symptom rather than a single health issue, it can be a cause or be caused by other underlying health issues. Head pain and pressure can have a variety of symptoms on its own but head pain-related brain fog has a whole different variety of symptoms. Understanding brain fog associated with head pain and pressure as well as what you can do about the symptoms can help manage brain fog symptoms and promote overall brain health and wellness. – Dr. Alex Jimenez D.C., C.C.S.T. Insight
Neurotransmitter Assessment Form
The following Neurotransmitter Assessment Form can be filled out and presented to Dr. Alex Jimenez. Symptoms listed on this form are not intended to be utilized as a diagnosis of any type of disease, condition, or any other type of health issue. �
In honor of Governor Abbott’s proclamation, October is Chiropractic Health Month. Learn more about the proposal. �
How often do you feel you have something that must be done? How often do you have difficulty concentrating before eating? Do you suffer from headaches and/or migraines? Head pain is commonly characterized by a variety of symptoms, including pain and discomfort, photophobia or light sensitivity, dizziness, lethargy, and mood changes. However, one of the most common symptoms of head pain is brain fog, which also causes its own variety of symptoms. In the following article, we will discuss brain fog associated with head pain and pressure as well as the common cause of brain fog and headache/migraine. �
The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 . �
Curated by Dr. Alex Jimenez �
Additional Topic Discussion: Chronic Pain
Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals, however, chronic pain is different than the average type of pain. With chronic pain, the human body will continue sending pain signals to the brain, regardless if the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient’s mobility and it can reduce flexibility, strength, and endurance.
Neural Zoomer Plus for Neurological Disease
�
Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual�s reactivity to 48 neurological antigens with connections to a variety of neurologically related diseases. The Vibrant Neural ZoomerTM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention. �
Formulas for Methylation Support
XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly,�Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic�Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
�
For your convenience and review of the XYMOGEN products please review the following link. *XYMOGEN-Catalog-Download �
* All of the above XYMOGEN policies remain strictly in force.
How often do you feel you have something that must be done? How often do you have difficulty concentrating before eating? Do you suffer from migraines and/or headaches?�A migraine headache is commonly characterized by a variety of symptoms, including pain and discomfort, photophobia or light sensitivity, dizziness, lethargy, and mood changes. However, one of the most common symptoms of migraine headaches is brain fog, which also causes its own variety of symptoms. In the following article, we will discuss brain fog associated with migraines and offer several simple tips to help manage migraine brain fog. �
Contents
What is Migraine Brain Fog?
Several people experience migraine-associated brain fog before the severe headaches occur, although it most commonly occurs after the migraines have passed. As a matter of fact, a research study demonstrated that almost 70 percent of people with migraines experience brain fog, which can last from a few hours to several days or more. This percentage may be even higher as symptoms of confusion and difficulty focusing or concentrating are also frequently reported, all of which can suggest the presence of post-migraine brain fog. According to researchers, migraine brain fog can include symptoms such as: �
forgetfulness or short-term memory loss
loss of sense of direction
inability to complete everyday tasks and activities
a brain that feels as if it “doesn’t function properly”
feeling as though you’re having to think through a fog
Migraine headache brain fog can make it difficult to participate and engage in daily tasks and activities. Cooking, which requires focus and concentration as well as multiple steps, may feel nearly impossible to do with this health issue. People who suffer from migraines may also feel that driving is downright dangerous, especially if their brain fog is accompanied by a lack of sense of direction. To others, people experiencing migraine brain fog may ultimately appear to be half-asleep. �
What Does Brain Fog Really Feel Like?
Many people have experienced moments where they walk into a room only to find out that they can no longer remember why they even walked into the room. Migraine patients, however, experience these symptoms much more frequently and much more severely. They may often find themselves forgetting what they are doing or where they are going, they become easily distracted, or completely lose track of their purpose. Migraine patients have described migraine-associated brain fog as a feeling of disconnection, trouble making complete sentences or thoughts, or simply as a heaviness or numbing of the mind. � Several people have characterized it as �feeling dumb.� However, the simple fact is that even the most intelligent individual can feel as though their brain has been reduced to little more than mush with migraine brain fog. This can ultimately also cause feelings of guilt over the lack of productivity and it is often aggravated due to challenges accurately explaining the symptoms of the post-migraine brain fog. It is fundamental for both healthcare professionals and patients to be able to recognize that these symptoms are still associated with migraine headaches, even though the pain may have subsided. �
Tips for Managing Migraine Brain Fog
Following a migraine headache, it may be necessary to return to everyday tasks and activities, in spite of the brain fog, including going to school or back to work, taking care of one�s family. The tips below will help ease migraine brain fog. �
Write Things Down
Keep a planner, utilize a smartphone, or stick post-its in relevant areas so that you’ll be able to see them later. Lists to track tasks or activities will help give you the confidence you need to know that you are not missing any important to-do items. �
Be as Organized as Possible
When your environment is organized, it becomes easier for you to find the things that you are looking for to keep moving forward with regular tasks and activities. Several specific organization strategies can include the following, such as: �
Utilizing clearly labeled basket organizers on your desk
Utilizing a filing system that is easy for both you and others to understand
Writing checklists of what you need to accomplish, including grabbing your keys, phone, and wallet, if necessary
Placing medicines into boxes with times and dates so that you will know whether or not you have taken them
Ask for Help if Needed
This is one of the most vital parts of managing migraine brain fog. You can’t always do everything yourself. If you need help, don’t be afraid to seek help from a healthcare professional. Be honest about your needs to achieve migraine brain fog relief. �
Brain fog can make people feel as if they’re not able to focus or concentrate accordingly and it’s commonly accompanied by fatigue and even migraine headaches. While brain fog is a symptoms rather than a single health issue, it can also have a variety of causes. Migraine headaches can have a variety of symptoms on their own but migraine-associated brain have has a whole different variety of symptoms. Understanding migraine brain fog and what you can do about the symptoms can help manage migraine brain fog symptoms and promote overall brain health and wellness. – Dr. Alex Jimenez D.C., C.C.S.T. Insight
Neurotransmitter Assessment Form
The following Neurotransmitter Assessment Form can be filled out and presented to Dr. Alex Jimenez. Symptoms listed on this form are not intended to be utilized as a diagnosis of any type of disease, condition, or any other type of health issue. �
In honor of Governor Abbott’s proclamation, October is Chiropractic Health Month. Learn more about the proposal. �
How often do you feel you have something that must be done? How often do you have difficulty concentrating before eating? Do you suffer from migraines and/or headaches? A migraine headache is commonly characterized by a variety of symptoms, including pain and discomfort, photophobia or light sensitivity, dizziness, lethargy, and mood changes. However, one of the most common symptoms of migraine headaches is brain fog, which also causes its own variety of symptoms. In the article above, we discussed brain fog associated with migraines and offered several simple tips to help manage migraine brain fog. � The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 . �
Curated by Dr. Alex Jimenez �
Additional Topic Discussion: Chronic Pain
Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals, however, chronic pain is different than the average type of pain. With chronic pain, the human body will continue sending pain signals to the brain, regardless if the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient’s mobility and it can reduce flexibility, strength, and endurance.
Neural Zoomer Plus for Neurological Disease
�
Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual�s reactivity to 48 neurological antigens with connections to a variety of neurologically related diseases. The Vibrant Neural ZoomerTM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention. �
Formulas for Methylation Support
XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly,�Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic�Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
�
� For your convenience and review of the XYMOGEN products please review the following link. *XYMOGEN-Catalog-Download �
* All of the above XYMOGEN policies remain strictly in force.
If you are suffering from any of these symptoms, then you might be experiencing an allergy attack in your body.
The Rise of Allergies
The rise of allergies has not gone unnoticed amongst the young and the old. The allergy disease has affected over 30% of individuals in many communities, particularly young children, have underscored the need for effective prevention strategies in their early lives. Some individuals will blame the increase in toxin exposure while others blame the food, but mostly everyone will admit that the answers to how the allergy disease comes from are still unclear. Whether it be food, environmental factors, or skin allergies, the common denominator that causes the allergies to develop is in the immune system, especially in its inflammatory department.
The body�s immune system is linked to the entire body microbiome, and it also resides in the gastrointestinal tract. It has been said that the health and function of the immune system are directly associated with the diversity as well as the health of the microbiome. So it is reasonable to consider the microbiome when healthcare professionals are seeking to solve the allergy enigma.
Types of Allergic Reactions
With most allergy reactions, they are manifested in either the gastrointestinal tract, respiratory tract, or the skin. It is not a surprise that these organ systems are also where the body’s microbiome is the most heavily concentrated. A variety of bacterial species make their homes in these organ systems since these three organ systems represent the primary portals of entry for these pathogens.
It is logically that the microbiome of the body is so heavily concentrated as it functions as the first line of defense against invading pathogens and antigens. When there is a weak microbiome, or it lacks biodiversity, it will become a weak defense system, and the immune system is required to “pick up the slack” by identifying and protecting the body against these foreign invaders, which includes the common allergens that a person can get.
Skin Allergies
Skin allergies are where the skin becomes red, bumpy, and itchy rashes to become irritating, painful, and embarrassing for some people. Rashes can be caused by many factors, including exposure to certain plants, an allergic reaction to specific medication or food, or by illnesses like measles or chickenpox. Eczema, hives, and contact dermatitis are the three types of skin rashes. Eczema and hives are the two most common types of skin rashes and are related to allergies.
Eczema: Also known as atopic dermatitis, can affect between 10 to 20 percent of children and 1 to 3 percent of adults. People with eczema will experience dry, red, irritated, and itchy skin. When it is infected, the skin may have small fluid-filled bumps that can ooze clear or yellowish liquid. Anyone with eczema can often have a family history of allergies.
Hives: Also known as urticaria, this skin rash is raised, red bumps or welts that appear on the body. Hives can cause two conditions, and they are acute urticaria and chronic urticaria. Acute urticaria is most commonly caused by exposure to an allergen or by an infection, while the causes of chronic urticaria are still mostly unknown.
Contact dermatitis: This skin rash is a reaction that appears when the skin comes in contact with an irritant or an allergen. Soaps, laundry products, shampoos, Excessive exposure to water, or the sun are some of the factors that can cause contact dermatitis. The symptoms can include rashes, blisters, itching, and burning.
Food Allergies
Anyone with a food allergy has an immune system that reacts to specific proteins found in food. Their immune system starts attacking these compounds as if they were harmful pathogens like a bacterium or a virus. Food allergies can affect 250 million to 550 million people in developed and developing countries.
The symptoms can range from mild to severe and can affect individuals differently. The most common signs and symptoms of an individual’s experience include:
The skin may become itchy or blotchy
Lips and face might swell
Tingling in the mouth
Burning sensation on the lips and mouth
Wheezing
Runny nose
Studies have found out that many people who think they have a food allergy may have a food intolerance. These two are entirely different because food intolerances do not involve the IgE antibodies, and the symptoms may be immediate, delayed, or similar to food allergies. Food intolerances occur due to proteins, chemicals, and other factors that can compromise the intestinal permeability. While food allergies mean that even a small amount of food is going to trigger the immune system, causing an allergic reaction.
Seasonal Allergies
Seasonal allergies are one of the most common allergic reactions that people get. About 8 percent of Americans experience it, according to the American Academy of Allergy, Asthma, and Immunology, and it is commonly known as hay fever. Hay fever occurs when the immune system overreacts to outdoor allergens like pollen, weeds, cut grasses, and wind-pollinated plants.� Seasonal allergies are less common in the winter; however, it is possible to experience allergic rhinitis year-round, depending on where the individual lives and on the allergy triggers they may have.
Symptoms of seasonal allergies can range from mild to severe, including:
Sneezing
Runny or stuffy nose
Water and itchy eyes
Itchy throat
Ear congestion
Postnasal drainage
Conclusion
Allergies are a disease that attacks the immune system and can be triggered by many factors, whether it be from food, environmental factors, or the toxins that a person is exposed to. There are ways to lower the allergy symptoms through medicine or foods that have prebiotics and probiotic nutrients that can reduce the reactions. Some products can help support the immune system and can offer nutrients to the gastrointestinal tract and metabolic support.
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues as well as functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or chronic disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .
References:
Brosseau, Carole, et al. �Prebiotics: Mechanisms and Preventive Effects in Allergy.� Nutrients, MDPI, 8 Aug. 2019, www.ncbi.nlm.nih.gov/pubmed/31398959.
Kerr, Michael. �Seasonal Allergies: Symptoms, Causes, and Treatment.� Healthline, 7 May, 2018, www.healthline.com/health/allergies/seasonal-allergies.
Molinari, Giuliano, et al. �Respiratory Allergies: a General Overview of Remedies, Delivery Systems, and the Need to Progress.� ISRN Allergy, Hindawi Publishing Corporation, 12 Mar. 2014, www.ncbi.nlm.nih.gov/pmc/articles/PMC3972928/.
Newman, Tim. �Food Allergies: Symptoms, Treatments, and Causes.� Medical News Today, MediLexicon International, 17 July 2017, www.medicalnewstoday.com/articles/14384.php.
Team, DFH. �Attack Allergies with Prebiotics.� Designs for health, 24 Oct. 2019, blog.designsforhealth.com/node/1133.
Unknown, Unknown. �Skin Allergies: Causes, Symptoms & Treatment.� ACAAI Public Website, 2019, acaai.org/allergies/types/skin-allergies.
Let’s be honest, making a change to your lifestyle is hard. Whether that is due to lack of time, motivation, or not knowing where to begin, there is one thing that makes it easier: accountability. This is where health coaching comes into play. Going through the process with someone and having another individual to talk about it with,� makes the change seem more achievable. The bottom line is that people need support. When it comes to changing one’s lifestyle and adapting new healthy behaviors, individuals who have support are more successful.
Contents
What Is A Health Coach?�
A health coach can be defined by The Institute for Integrative Nutrition as, ” a wellness authority and supportive mentor who motivates individuals to cultivate positive health choices. Health coaches educate and support clients to achieve their health goals through lifestyle and behavior adjustments.�
Health coaches are becoming more and more essential as modern medicine continues to improve. Now more than ever, the medical field is advancing at high rate speeds and practitioners do not always have the available time some patients need. Here is where health coaches come into play. Essentially, the position of a health coach was created to fill the void in many doctor offices.� Many doctors contribute but do not have the time or resources to help each patient build healthy habits on a day to day basis. However, health coaches are available to be a supportive mentor who help and guide patients in making healthy lifestyle changes.
What Does A Health Coach Do?�
Health coaches play a vital role in modern medicine. Health coaches can work in multiple settings including for a doctor, a spa, a gym, wellness centers, or even have their own private practice. Health coaches help individuals make lasting changes and keep patients on track to feel their best. In addition to this, health coaches motivate, push, encourage, and create plans with patients to optimize energy and decrease stress and fatigue.
Health coaches are not just for diet and exercise help, but for other aspects of life as well. Health coaches are able to help with stress, sleep, relationships, habits, and even one’s career.
Health coaches work with individuals to go through the problem areas in their life and give them tools to improve their lifestyles. By working with a health coach, the individual begins to learn and create habits that will affect and improve their lives while also giving them the essential life skills they can use for a lifetime.� One of the main things that coaches do is aid patients in setting goals. For many, goals are set but are not attainable, healthy, nor realistic. Health coaches work to break down these goals with patients into smaller, more reachable goals. This helps patients push themselves and not get discouraged because they are hitting these smaller marks along the way.
Aside from setting goals, health coaches also prepare the patient for the emotional fallout that can occur. As mentioned earlier, lifestyle changes are not easy and do not occur overnight. This being said, it is normal to have negative emotions regarding the subject along the way. Health coaches are prepared for this and will help you to not only work through them but learn to adapt to these situations and how to overcome the barriers.
How Can You Benefit?�
In the United States, over half of the adult population is affected by at least one chronic disease, many having to do with joint inflammation (Pecoraro, 2019).� Integrative health coaching allows patients to visualize their goals and work with their health coach to properly identify their values and create action steps to achieve optimal health and wellbeing.
People can utilize health coaches at any moment in time. However, many people choose to have a health coach help them after they receive a diagnosis or are overall unhappy in their health and lifestyle choices.
Health coaches are respectful of the personal knowledge one has of their own life and body. Thus, letting the patient have a say in their plan and protocol. This is beneficial because if a patient is included in the creation of their health plan, they are more likely to comply and make it attainable. Not only does this build trust in the professional relationship, but it allows a health coach to consider all areas in the patient’s life.
Individuals can benefit by learning to lessen health issues, problem solve, and gain a new perspective on their life.
A health coach can do a lot more than just aid in diet and exercise. As one can see, health coaches are helpful in many different aspects of one’s life. The qualifications for a health coach can vary. Personally, I have a bachelors degree in Exercise Science with an emphasis in Health Education from Grand Canyon University. In addition to this, I gained my Exercise Physiologist Certification through the American College of Sports Medicine (ACSM). With this background, I am knowledgeable in the pillars of health and how to successfully guide an individual. Almost every person can benefit from a health coach in at least one way. – Kenna Vaughn, Senior Health Coach
The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or chronic disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.
IFM's Find A Practitioner tool is the largest referral network in Functional Medicine, created to help patients locate Functional Medicine practitioners anywhere in the world. IFM Certified Practitioners are listed first in the search results, given their extensive education in Functional Medicine
� 
Fasting is where a person does not consume food or beverages at least for twelve hours during the day. When a person starts fasting, they will notice that their metabolism and their hormones will change in their bodies. There is 
Certain environmental factors can damage the tight junction, and the result is that it can increase the intestinal permeability, which causes intestinal hyperpermeability or leaky gut in the body. Contributing factors can increase intestinal permeability like an excessive amount of saturated fats and alcohol, deficiencies in nutrients, chronic stress, and infectious diseases.
The symptoms can range from mild to severe and can affect individuals differently. The most common signs and symptoms of an individual’s experience include:
