Neurological diseases, including well-known neurodegenerative disorders like Alzheimer’s disease (AD) and Parkinson’s disease (PD) as well as other rare health issues, such as Huntington’s disease (HD) and amyotrophic lateral sclerosis (ALS), affect millions of people worldwide. Unfortunately, these are estimated to increase due to the aging population. Currently, there is no treatment available for any neurodegenerative disorder. Treatments for symptoms are available for several neurological diseases, such as PD and HD, but the therapeutic benefits are limited. Although the causes and symptoms for these health issues are different for each neurodegenerative disorders, their molecular pathogeneses share common underlying factors and characteristics, including excessive levels of reactive oxygen species (ROS), mainly due to mitochondrial impairment, neuroinflammation, and disturbances in protein homeostasis (proteostasis). This increases the possibility of developing a universal treatment that will focus on targeting the common triggers of neurological diseases. �
Nrf2 Activation Pathways and the Human Brain
The transcription factor, Nrf2, regulates the main endogenous defense mechanism against oxidative and xenobiotic stress and inflammation. Nrf2 also plays a fundamental role in the management of mitochondrial function and cellular proteostasis, which suggests the possible benefits of Nrf2 to control neurodegenerative disorders. When under stress, Nrf2 activates the transcriptional upregulation of a large network of cytoprotective genes that allow adaptation and survival. The levels and activity of Nrf2 are controlled through ubiquitination and proteasomal degradation mediated by several ubiquitin ligase systems, including Keap1-Cul3/Rbx1, ?-TrCP-Cul1, and Hrd1. Keap1 is the most well understood key regulator of Nrf2. �
Keap1 functions as a primary sensor for electrophiles and oxidants, which chemically change certain cysteines in Keap1, leading to conformational changes that protect Nrf2 from Keap1-associated degradation. Subsequently, Nrf2 will accumulate and then translocate to the nucleus where it binds as a heterodimer with a small Maf transcription factor to antioxidant response elements in the promoter of its target genes to activate the expression of a large network of detoxification, antioxidant, and anti-inflammatory genes as well as other genes involved in the clearance of damaged proteins. Of particular interest is also the upregulation of genes responsible in the biosynthesis and the regeneration of glutathione (GSH), a major intracellular antioxidant. Moreover, Nrf2 also suppresses proinflammatory responses through transcriptional repression and it is involved in the regulation of mitochondrial function. Keap1 and p62/SQSTM1 are Nrf2-associated proteins and main regulators of negative and positive feedback loop mechanisms. In addition, p62 targets Keap1 for selective degradation through autophagy, therefore contributing to the sustained Nrf2 activation response. �
Aging has been associated with the increase in ROS and chronic inflammation, which suggests a loss of adaptability and/or impairment of Nrf2 signaling, which are particularly pronounced in age-dependent neurodegenerative disorders. Surprisingly, rare mutations in SQSTM1 can cause susceptibility to the human neurodegenerative disorder, ALS as well as frontotemporal lobar degeneration, and are associated with muted Nrf2 activation responses in clinical trials. Research studies suggest a reciprocal correlation and show negative effects of mutant disease-related proteins on Nrf2 signaling, thus suggesting the inhibition of the Nrf2 pathway as a possible mechanism underlying neurodegeneration and health issues. �
Nrf2 Activation for Neurodegenerative Disorders
ALS, an adult-onset neurodegenerative disorder caused by the selective death of motor neurons in the brain and spinal cord, is commonly characterized by progressive muscle weakness and atrophy which is generally considered to be fatal, typically within 5 years of diagnosis. ALS has a predominant sporadic ALS form with no apparent genetic component, however, approximately 5 to 10 percent of cases show an autosomal dominant inheritance pattern or familial form of the disease, known as fALS, with is known to cause gene mutations. The symptoms of sporadic ALS and familial ALS are similar, which suggests the involvement of common pathogenic mechanisms, including oxidative stress and neuroinflammation. �
Research studies show that oxidative stress and neuroinflammation should be the key therapeutic targets of Nrf2 signaling in ALS. Genetic research studies in ALS mouse models have shown a considerable therapeutic effect of increased Nrf2 levels in astrocytes, the main GSH producers for neurons. Furthermore, Nrf2 signaling is fundamental for controlling neuroinflammation in ALS through the management of the effects of activated microglial cells on overall neuronal survival. Consistent with the therapeutic potential of Nrf2 signaling, treatment with small molecule activators, including the extremely potent cyanoenone triterpenoids, has ultimately shown efficacy in research study mouse ALS models. �
The neuroprotective potential of Nrf2 activation has been evaluated in experiments utilizing genetic mouse HD models. HD is an autosomal dominant and highly penetrant neurodegenerative disorder, which results from the pathological expansion of a trinucleotide CAG repeats encoding polyglutamines in HTT protein. Brains from patients with HD usually show marked striatal and cortical atrophy at the time of diagnosis. Once motor or other symptoms become apparent, generally throughout midlife, the affected individuals become increasingly disabled over the course of 15 to 25 years before eventually succumbing to the effects of severe physical and mental deterioration, according to evidence from research studies. �
Complex pathogenic mechanisms have been shown in HD, however, excessive oxidative stress has been recognized as a fundamental driver of pathology. The harmful role of oxidative stress has been described in both HD patients and in experimental clinical trial models and it is potentially due to the neuronal sensitivity of an excess in ROS. The levels of several Nrf2-dependent antioxidant proteins, including glutathione peroxidases, catalase, and superoxide dismutase 1, are increased in human HD brains as compared with non-disease controls, suggesting a partial activation of Nrf2 defense signaling yet insufficient enough to block progressive neurodegeneration. Pharmacological activation of Nrf2 results in the broad antioxidant effects of HD in mouse brains and ameliorates the neurological phenotype. Increased expression of several key inflammatory mediators has been shown in the blood, the striatum, the cortex, and the cerebellum from postmortem patient HD tissues, however, neuroinflammation in HD patients seems to be less pronounced than in ALS or PD patients. �
Neurological Disease Treatment with Nrf2 Activation
Finally, the neurological phenotype of the most common neurological disease and neurodegenerative disorder, PD, can be challenged by Nrf2 activation. PD is characterized by the progressive loss of dopaminergic neurons in the substantia nigra and the profound reduction of dopamine in the striatum. Currently available dopaminergic treatments offer relief from several symptoms but these only address the motor manifestations. Multiple genetic and environmental factors have been suggested in the etiology of PD, however, like ALS, the majority of the clinical cases are sporadic. The discovery that the environmental neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes Parkinson’s disease in humans, led to the development of the MPTP mouse model of disease, which to date, remains one of the most highly utilized animal models of sporadic PD, including the evaluation of drug efficiency. Nrf2 activators showed neuroprotective effects in MPTP mice, which are associated with a reduction of oxidative damage and neuroinflammation. The identification of causative mutations in SNCA, the gene encoding ?-synuclein (aSyn), developed genetic mouse PD models, in which daily oral delivery of the Nrf2 activator dimethyl fumarate (DMF) protected nigral dopaminergic neurons against aSyn toxicity. �
Although oxidative stress and neuroinflammation are pathological hallmarks of AD, a therapeutic role of Nrf2 signaling has developed more slowly, perhaps due to the complexity of disease pathogenesis and readouts of efficiency. Nonetheless, there is a number of recent research studies that demonstrate the efficiency of Nrf2 activators in AD mouse models. � DMF, a U.S. FDA-approved drug (Tecfidera, Biogen-Idec) for the treatment of relapsing multiple sclerosis, activates Nrf2 through the regulation of the Keap1 sensor. DMF is of seemingly low potency and specificity, which prevents neurodegeneration. Drug-like molecules with a similar mechanism of action or with the ability of direct interference with the Keap1/Nrf2 interaction are emerging. The data demonstrate the feasibility to develop Nrf2 activators for treatment. �
In summary, although the causes and symptoms of neurological diseases are different, neurodegenerative disorders share similar molecular mechanisms, which could be regulated and managed with Nrf2 activators. Moreover, targeting Nrf2 signaling may offer a safe and effective treatment approach for a variety of these health issues. Because pharmacological Nrf2 activation targets the broad mechanisms of these health issues, all neurodegenerative conditions would be eligible for treatment. Furthermore, the main goal is to develop noninvasive oral treatment(s) for patients under the supervision of healthcare professionals, which targets both sporadic and familial patients. – Dr. Alex Jimenez D.C., C.C.S.T. Insight
Neurotransmitter Assessment Form
The following Neurotransmitter Assessment Form can be filled out and presented to Dr. Alex Jimenez. Symptoms listed on this form are not intended to be utilized as a diagnosis of any type of disease, condition, or any other type of health issue. �
Neurological diseases, including well-known neurodegenerative disorders like Alzheimer’s disease (AD) and Parkinson’s disease (PD) as well as other rare health issues, such as Huntington’s disease (HD) and amyotrophic lateral sclerosis (ALS), affect millions of people worldwide. Unfortunately, these are estimated to increase due to the aging population. Currently, there is no treatment available for any neurodegenerative disorder. Treatments for symptoms are available for several neurological diseases, such as PD and HD, but the therapeutic benefits are limited. Although the causes and symptoms for these health issues are different for each neurodegenerative disorders, their molecular pathogeneses share common underlying factors and characteristics, including excessive levels of reactive oxygen species (ROS), mainly due to mitochondrial impairment, neuroinflammation, and disturbances in protein homeostasis (proteostasis). This increases the possibility of developing a universal treatment that will focus on targeting the common triggers of neurological diseases. �
The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 . �
Curated by Dr. Alex Jimenez �
References: �
Dinkova-Kostova, Albena T, et al. �Activation of Nrf2 Signaling as a Common Treatment of Neurodegenerative Diseases.� Activation of Nrf2 Signaling as a Common Treatment of Neurodegenerative Diseases | Neurodegenerative Disease Management, 23 May 2017, www.futuremedicine.com/doi/full/10.2217/nmt-2017-0011#.
Additional Topic Discussion: Chronic Pain
Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals, however, chronic pain is different than the average type of pain. With chronic pain, the human body will continue sending pain signals to the brain, regardless if the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient’s mobility and it can reduce flexibility, strength, and endurance.
Neural Zoomer Plus for Neurological Disease
�
Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual�s reactivity to 48 neurological antigens with connections to a variety of neurologically related diseases. The Vibrant Neural ZoomerTM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention. �
Food Sensitivity for the IgG & IgA Immune Response
�
Dr. Alex Jimenez utilizes a series of tests to help evaluate health issues associated with food sensitivities. The Food Sensitivity ZoomerTM is an array of 180 commonly consumed food antigens that offers very specific antibody-to-antigen recognition. This panel measures an individual�s IgG and IgA sensitivity to food antigens. Being able to test IgA antibodies provides additional information to foods that may be causing mucosal damage. Additionally, this test is ideal for patients who might be suffering from delayed reactions to certain foods. Utilizing an antibody-based food sensitivity test can help prioritize the necessary foods to eliminate and create a customized diet plan around the patient�s specific needs. �
Formulas for Methylation Support
XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly,�Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic�Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
�
For your convenience and review of the XYMOGEN products please review the following link. *XYMOGEN-Catalog-Download �
* All of the above XYMOGEN policies remain strictly in force.
How often do you feel unclear thoughts or concentration and brain fog? How often do you experience pain, discomfort, and/or inflammation? How often do you feel mental and physical fatigue after eating meals? Inflammation is an essential immune response, however, chronic inflammation, especially in the brain and the joints, can cause a variety of health issues. Fortunately, there are many natural remedies that can help reduce inflammation, including turmeric or curcumin. �
Turmeric, sometimes known as Indian saffron or the golden spice, is a tall plant that grows in Central America and Asia. The turmeric that we commonly see on shelves and in spice cabinets is made of the ground roots of the plant. Moreover, the bright yellow color of processed turmeric has inspired many cultures to use it as a dye. Ground turmeric is also the main ingredient in curry powder. Capsules, powders, teas, and extracts are several ways that turmeric is available commercially. �
Curcumin is the active ingredient found in turmeric and it has many powerful biological properties. Ayurvedic medicine, a traditional Indian system of treatment, recommends utilizing turmeric for a variety of health issues, including chronic pain and inflammation. Western medicine has started to evaluate the use of turmeric as a pain reliever. �In the following article, we will discuss the health benefits and risks of turmeric as well as how these can affect overall health and wellness. �
Health Benefits of Turmeric
According to the Arthritis Foundation, research studies in which turmeric has been utilized helped reduce chronic inflammation in the clinical trial participants. The anti-inflammatory properties of turmeric, or curcumin, may help reduce arthritis joint pain and discomfort. Together with other supplements, such as an Nrf2 activator, research studies have shown that these can reduce inflammatory cytokines by dampening NF-?B activity and down-regulating COX, LOX, iNOS, matrix metalloproteiases, INF-a, and interleukines-1, 2, 6, 8, 12 as well as chemokines. The Arthritis Foundation suggests taking capsules of 400 to 600 milligrams (mg) of turmeric or curcumin up to three times per day for chronic pain and inflammation. �
Many researchers and healthcare professionals believe that turmeric may not only be efficient at reducing inflammation but it may also be safe and effective as a chronic pain reliever. As previously mentioned, the spice is reputed to help relieve arthritis as well as fibromyalgia symptoms. Research tudies seem to support the utilization of turmeric for pain relief, with one source noting that it seemed to work as well as ibuprofen (Advil) in people with arthritis. Although dosing recommendations seem to vary, those who participated in the research study took 800 mg of turmeric in capsules, each day. �
Turmeric has also recently been getting a lot of attention because of its antioxidant abilities. The antioxidant effects of turmeric appear to be so powerful that it may even help stop or prevent your liver from being damaged by toxins. This could be good news for people who take strong medicines for diabetes or any other health issues that may damage their liver through long-term utilization. Curcumin has also shown great promise as a type of cancer treatment. Research studies suggest that curcumin can have protective effects against pancreatic cancer, prostate cancer, and multiple myeloma. �
Turmeric is utilized in curry powder is because it helps add a delicious element to foods. However, turmeric can also play a fundamental role in the digestive process of that food. Because of its antioxidant and anti-inflammatory properties, turmeric can help promote healthy digestion. It’s utilized in ayurvedic medicine as a digestive system healing agent. Today, Western medicine has started to evaluate how turmeric, or curcumin, can help with gut inflammation as well as gut permeability, two measures of your digestive efficiency. Turmeric is even being explored as a possible treatment approach for irritable bowel syndrome (IBS). Turmeric can have many health benefits but curcumin supplements may also have several health risks. �
Health Risks of Turmeric
The same healing agents in turmeric that support healthy digestion can unfortunately also cause irritation when consumed in large amounts. Several research study participants looking at the utilization of turmeric as a type of cancer treatment had to drop out of the clinical trial because their digestive system was so negatively affected by the spice. Turmeric stimulates the stomach to produce more gastric acid. Although this can help with digestion, it can negatively affect digestion for others. �
Turmeric’s purifying properties may also make you bleed more easily. It’s not completely understood why this happens. However, people who take blood-thinning medicines, such as warfarin (Coumadin) should avoid consuming large doses of turmeric or curcumin.�
Researchers and healthcare professionals hypothesize that turmeric’s other benefits, including its capability to lower blood pressure and cholesterol, may have something to do with how turmeric affects your blood. Furthermore, researchers and healthcare professionals believe that the way curcumin is extracted from turmeric can be the cause of this health issue. Approximately 95 percent of curcumin in the U.S. is extracted by carcinogenic solvents. �
You may have also heard that eating foods seasoned with curry can stimulate labor. Although there’s little evidence to back up this claim, research studies suggest that turmeric can help ease symptoms of PMS. But perhaps, there may be some truth behind the old wives’ tale. Because of its blood-thinning effects alone, however, pregnant women are recommended to avoid taking turmeric supplements. Adding small amounts of turmeric as a spice to food or meals shouldn’t be a problem. �
The Takeaway of Turmeric
It appears that there are many health benefits to including turmeric as a part of your regular diet. The golden spice supports a healthy immune system, helps relieve chronic pain, and can even help promote healthy digestion, among other health benefits. However, because of some of its health risks and side effects, turmeric or curcumin may not be worth taking for several people. It’s essential to utilize caution when deciding whether turmeric is something you may want to try. As with any alternative treatment option, talk with your doctor before you utilize turmeric to treat any health issue. If you want to buy a turmeric or curcumin supplement, then there is an excellent selection online with thousands of great customer reviews. �
Turmeric, or curcumin, is a powerful, natural remedy which has been demonstrated to have many health benefits, especially for chronic pain and inflammation, among others. However, too much of the powerful, golden spice can also have several health risks and side effects. It’s fundamental to talk to a healthcare professional to discuss if turmeric or curcumin is a good treatment option. Turmeric, or curcumin, can be utilized for a variety of health issues, including arthritis and fibromyalgia. Make sure to talk to a doctor before using turmeric or curcumin supplements. – Dr. Alex Jimenez D.C., C.C.S.T. Insight
Neurotransmitter Assessment Form
The following Neurotransmitter Assessment Form can be filled out and presented to Dr. Alex Jimenez. Symptoms listed on this form are not intended to be utilized as a diagnosis of any type of disease, condition, or any other type of health issue. �
How often do you feel unclear thoughts or concentration and brain fog? How often do you experience pain, discomfort, and/or inflammation? How often do you feel mental and physical fatigue after eating meals? Inflammation is an essential immune response, however, chronic inflammation, especially in the brain and the joints, can cause a variety of health issues. Fortunately, there are many natural remedies that can help reduce inflammation, including turmeric or curcumin. �
The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 . �
Curated by Dr. Alex Jimenez �
Additional Topic Discussion: Chronic Pain
Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals, however, chronic pain is different than the average type of pain. With chronic pain, the human body will continue sending pain signals to the brain, regardless if the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient’s mobility and it can reduce flexibility, strength, and endurance.
Neural Zoomer Plus for Neurological Disease
Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual�s reactivity to 48 neurological antigens with connections to a variety of neurologically related diseases. The Vibrant Neural ZoomerTM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention. �
Food Sensitivity for the IgG & IgA Immune Response
Dr. Alex Jimenez utilizes a series of tests to help evaluate health issues associated with food sensitivities. The Food Sensitivity ZoomerTM is an array of 180 commonly consumed food antigens that offers very specific antibody-to-antigen recognition. This panel measures an individual�s IgG and IgA sensitivity to food antigens. Being able to test IgA antibodies provides additional information to foods that may be causing mucosal damage. Additionally, this test is ideal for patients who might be suffering from delayed reactions to certain foods. Utilizing an antibody-based food sensitivity test can help prioritize the necessary foods to eliminate and create a customized diet plan around the patient�s specific needs. �
Formulas for Methylation Support
XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly,�Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic�Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
�
For your convenience and review of the XYMOGEN products please review the following link. *XYMOGEN-Catalog-Download �
* All of the above XYMOGEN policies remain strictly in force.
If you are experiencing any of these situations, you might be experiencing inflammation, and it might affect your endocrine system.
Inflammation and the Endocrine System
Inflammation is a defense mechanism in the body. The immune system can recognize the damaged cells, irritants, and pathogens that cause harm to the body and began the healing process. When the inflammation turns into chronic inflammation, it can cause several diseases and conditions in the body and can cause harm to an individual.
Inflammation can cause dysfunction when it is in the endocrine system. The endocrine system is a series of glands that produce and secretes hormones that the body needs and uses for a wide range of functions. When the endocrine glands produce hormones, they are sent into the bloodstream to the various tissues in the body. Once they are in the various tissues, the hormone signals the tissues to tell them what they are supposed to do. When the glands do not produce the right amount of hormones, various diseases like inflammation can affect the body.
Inflammation Symptoms and Causes
Two questions are asked concerning the interaction of the endocrine system with inflammation: How does inflammation influences the endocrine system, and does it influences disease? How do hormones influence inflammation and immune cells? A theory had integrated both questions and has recently been demonstrated in the context of chronic inflammation considering a rheumatic disease.
So how does inflammation influence the endocrine system? Inflammation symptoms can vary depending on if it is acute or chronic. The effects of acute inflammation are summed up by the acronym PRISH. They include:
Pain: The inflamed area is most likely to be painful, especially during and after touching. The chemicals that stimulate the nerve endings are released, making the area more sensitive.
Redness: This occurs due to the capillaries in the area that is filled with more blood than usual.
Immobility: There may be some loss of function in the region of the inflammation where the injury has occurred.
Swelling: A buildup of fluid causes this.
Heat: Heat is caused by having more blood flow to the affected area and making it warm to the touch.
These acute inflammation signs only apply to an inflammation on the skin. If the inflammation occurs deep inside the body, like the endocrine system and the internal organs, some of the signs may be noticeable. Some internal organs may not have sensory nerve endings nearby; for example, they will not have pain.
With the effects of chronic inflammation, it is long term and can last for several months or even years. The results from chronic inflammation can be from:
An autoimmune disorder that attacks normal healthy tissue and mistaking it for a pathogen that causes diseases like fibromyalgia.
An industrial chemical that is exposed to a low level of a particular irritant over a long period.
Failure to eliminate whatever was causing acute inflammation.
Some of the symptoms of chronic inflammation can be present in different ways. These can include:
Fatigue
Mouth sores
Chest pains
Abdominal pain
Fever
Rash
Joint pain
When inflammation affects the endocrine system, it can cause the body’s system to be unbalanced, and it can lead to chronic long term illnesses.
With the second question, it is asking how do hormones influence inflammation and the immune system? When the hormone levels are either too high or too low, it can have several effects on a person’s health. The signs and symptoms can depend on hormones that are out of balance.
Inflammation and Hormones
Research has shown that some of the conditions that are affecting the endocrine system can lead to autoimmune disorders. High levels of hormones can lead to hyperthyroidism, Cushing syndrome, and Graves disease. While low levels of hormones can lead to hypothyroidism and Addison disease. When the levels of the hormones are either too high or too low, the body fluctuates from either weight gain or weight loss and disrupting the glucose levels. This can cause a person to get diabetes and obesity.
Obesity is the main risk factor for type 2 diabetes. During the development of obesity, subclinical inflammatory activity in the tissues are activated and involves the metabolism and energy homeostasis. In the body, intracellular serine/threonine kinases are activated in response to those inflammatory factors. They can catalyze the inhibitory phosphorylation of the key proteins of the insulin-signaling pathway, leading to insulin resistance in the body.
Studies have shown that inflammation is a general tissue response to a wide variety of stimuli. When inflammation is not adequately regulated, inflammatory responses may be exaggerated or ineffective, which can lead to immune dysfunction, recurring infections, and tissue damage, both locally and systemically. With various hormones, cytokines, vitamins, metabolites, and neurotransmitters being key meditators of the immune and inflammatory responses to the endocrine system.
Another study shows that aging, chronic psychological stress, and mental illnesses are also accompanied by chronic smoldering inflammation. Chronic smoldering inflammation in humans is already established with elevations of serum levels, leading to an increase in resting metabolic rate.
Conclusion
So inflammation is a double edge sword where it can heal the body but also cause the body harm if it is deep into the internal organs and body systems. With the endocrine system, the levels of the hormones can fluctuate from going too high or too low and affecting the tissues in the body, causing inflammation. �When an individual is suffering from chronic inflammation, it can change their lifestyle drastically. Some products are here to help counter the metabolic effects of temporary stress and make sure that the endocrine system is supported as well.
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.
References:
Coope, Andressa, et al. �MECHANISMS IN ENDOCRINOLOGY: Metabolic and Inflammatory Pathways on the Pathogenesis of Type 2 Diabetes.� European Journal of Endocrinology, U.S. National Library of Medicine, May 2016, www.ncbi.nlm.nih.gov/pubmed/26646937.
Felman, Adam. �Inflammation: Causes, Symptoms, and Treatment.� Medical News Today, MediLexicon International, 24 Nov. 2017, www.medicalnewstoday.com/articles/248423.php.
Salazar, Luis A., et al. �The Role of Endocrine System in the Inflammatory Process.� Mediators of Inflammation, Hindawi, 29 Sept. 2016, www.hindawi.com/journals/mi/2016/6081752/.
Seladi-Schulman, Jill. �Endocrine System Overview.� Healthline, 22 Apr. 2019, www.healthline.com/health/the-endocrine-system.
Straub, Rainer H. �Interaction of the Endocrine System with Inflammation: a Function of Energy and Volume Regulation.� Arthritis Research & Therapy, BioMed Central, 13 Feb. 2014, www.ncbi.nlm.nih.gov/pmc/articles/PMC3978663/.
Members of the military perform physically and psychologically demanding jobs every day. Research has found that conservative medical care, like chiropractic treatment, can absolutely help with back pain.
A study has shown that chiropractic treatment brought serious relief to female veterans with back pain.
Causes
The causes of back pain can be viewed as being mechanical, organic or idiopathic. Spinal conditions can be congenital or from birth and can be an acquired disorder that develops later in life.
Mechanical pain is triggered by spinal movement and involves spinal structures, like the facet joints, intervertebral discs, vertebral bodies, ligaments, muscles or soft tissues.
Organic pain is attributed to disease, like spinal cancer.
Idiopathic means the cause is unknown.
Back Pain & Female Veterans
Low back pain is a musculoskeletal condition and for female veterans has become a chronic condition. For these women, the condition seems to stem from repeated and prolonged deployments as contributors/causes to more prolonged injuries.
Female veterans had a higher rate of service-related disability compared to male veterans.
Having to live with a disease or chronic condition can impact the quality of life significantly. It can result in short- or long-term disability, it affects individuals financially from time off work and reroutes those financial resources to health care needs.
Chiropractic Research
Researchers reviewed 70 female veterans that utilized chiropractic treatment for their back pain.
The average patient was:
Around 35-40-years old
Veteran patients were included in the study by:
Visiting a chiropractic clinic over a 7-year period
Between 18 – 70 years old during treatment
Needed at least two treatments
Treatments included:
Flexion-distraction therapy
This is gentle intermittenttraction, along with manual pressure applied to the back.
Myofascial release
Massage therapy to muscles, joints, ligaments.
Spinal manipulative therapy
This involves the chiropractor�s hands performing�a high-velocity thrust to regions within the low back.
Spinal mobilization
Similar to spinal manipulative therapy, but with gentler repetitive motions around the affected area.
These treatments were applied alone or in combination, guided by:
The nature of the back pain complaint
Response
Pain severity
Patient’s preference
The patient’s tolerance of the various treatments
To help measure how effective the treatment was, the research team used the Back Bournemouth Questionnaire.
Pain is a complex biological process that involves both physical and mental health factors.
The test is one way to understand the multi-dimensional nature of pain.
Other factors to consider, specifically with military veterans were other health conditions like:
Post-traumatic stress disorder
Military sexual trauma
By comparing the patients Back Bournemouth Questionaire results at the beginning of treatment and then at the end, researchers found that these patients� low back pain improved by 85% with chiropractic treatment.
The American College of Physicians Clinical Practice Guidelines includes and stresses that doctors refer patients first to a chiropractor/physical therapist and undergo spinal manipulation as the recommended non-drug treatment for back pain before recommending medications or surgery.
The guidelines focus on:
Exercise
Stress reduction
Integrative therapies
Chiropractic spinal manipulation�treatment has been shown to effectively treat back pain for everyone.�
We focus on what works for you and strive to create fitness and better the body through researched methods and total wellness programs. These programs are natural and use the body�s own ability to achieve goals of improvement. To all of our veterans, we thank you for your service.
Get Rid of *LOW BACK PAIN* with Custom Foot Orthotics | El Paso, TX.
Approximately 80 percent of the population will experience some type of back pain sometime throughout their lifetime.
Custom-made functional foot orthotics can help support and promote the natural alignment of the spine.
NCBI Resources
It is important to know the cause of back pain to figure out the proper treatment plan. Otherwise, one could receive treatment for the wrong diagnosis and exacerbate the existing injury.
If you are experiencing any of these situations, then you might be experiencing fibromyalgia.
Fibromyalgia is a common and chronic syndrome that causes pain and mental distress in the body. It causes widespread musculoskeletal pain, and it is accompanied by fatigue, sleep memory, and mood issues to the body.�The symptoms may be similar to arthritis; however, fibromyalgia is a rheumatic condition and causes soft tissue pain or myofascial pain.
There are three symptoms that fibromyalgia causes a person to have discomfort in their daily lives. They are:
Widespread pain: This pain is associated with fibromyalgia, and it is described as a constant dull ache that can last for at least three months. For it to be considered as widespread pain, it must occur both sides of the body, as well as above and below the waist.
Fatigue:Individuals with fibromyalgia often awaken tired, even though they have been sleeping for long periods. The pain that fibromyalgia causes can disrupt the person’s sleep patterns, causing them to have sleep disorders such as restless legs syndrome and sleep apnea.
Cognitive difficulties: This symptom is commonly known as �fibro fog.� It impairs the person�s ability to focus, pay attention, and concentrate on mental tasks.
Other symptoms can include:
IBS (irritable bowel syndrome)
Stiff joints and muscles in the morning
Headaches
Problems with vision
Nausea
Pelvic and urinary problems
Depression and anxiety
In the past, studies have shown that patients diagnosed with fibromyalgia had 11 out of 18 specific trigger points all around their bodies. Healthcare providers would check their patients and document how many of these points were painful to their patients by firmly, but gently, pressing their bodies to get a diagnosis.
The typical trigger points include:
The back of the head
The tops of the shoulders
The upper chest
The hips
The knees
The outer elbows
Nowadays, in a 2016 revised diagnostic criteria, healthcare providers can diagnose patients with fibromyalgia if the patient has pain in 4 out of 5 areas of the body that is causing them pain. The protocol when diagnosing patients is referred to as �multisite pain.�
Fibromyalgia Affecting the Endocrine System
When it comes to fibromyalgia, the symptoms are associated with the endocrine system. Research shows that fibromyalgia-like symptoms such as muscle pain and tenderness, exhaustion, reduced exercise capacity, and cold intolerance can resemble symptoms that are associated with the endocrine dysfunction like hypothyroidism and adrenal or growth hormone insufficiency.
More research has stated that fibromyalgia causes a person to develop chronic fatigue syndrome. Chronic fatigue syndrome causes the body to have a deficiency of serotonergic activity and the hypofunction of sympathetic nervous system function that could contribute to the abnormalities of the central components of the HPA axis. It can distort the body’s hormonal pattern that is being attributed to the hyperactivity of the CRH neurons. The hyperactivity caused by the CRH neurons can be driven and sustained by stress being exerted by chronic pain that has originated in the musculoskeletal system or the alternation of the central nervous system mechanism of nociception.
Researchers believe that repeated nerve stimulation causes the brains of patients with fibromyalgia to change. The change causes an abnormal increase level of certain chemicals (neurotransmitters) in the brain that signals pain. In addition, the brain�s pain receptors will develop a sort of memory of the pain that is causing problems to the patient�s body and causing them to be more sensitive since the signals are overreacting.
Treating Fibromyalgia
Even though fibromyalgia pain can be uncomfortable and consistent enough to interfere with a person�s daily routine. There are ways to relieve the pain and inflammation that fibromyalgia causes the body. Pain medication can bring down the inflammation and help a person sleep a little better. Other safe treatments that can help manage fibromyalgia pain are:
Acupuncture: Acupuncture is a Chinese medical system that uses needles to cause changes in the blood flow and the levels of neurotransmitters in the brain and spinal cord.
Therapy: A variety of different therapies can help a person reduce the effects that fibromyalgia has caused.
Yoga and tai chi: These practices combine meditation, slow movements, deep breathing, and relaxation � both help control fibromyalgia symptoms.
Reducing stress: Developing a plan to avoid or limit overexertion and emotional stress is useful when dealing with fibromyalgia. Learning to meditate and trying stress management techniques can help a person feel calm and recharged for the rest of the day.
Getting enough sleep: Since fatigue is one of the main characteristics of fibromyalgia, getting enough sleep is essential. Practicing good sleep habits and going to bed and getting up at the same time each day can lessen the effects of fatigue.
Exercising regularly: At first, exercising may increase the pain, but doing it gradually and regularly over time can decrease the symptoms. This can be walking, swimming, biking, and water aerobics can be beneficial to the body.
Pacing yourself: Keeping track of activities is beneficial for people with fibromyalgia. Moderation of daily activities on the good days can help a person overcome the symptoms when they flare-up.
Maintaining a healthy lifestyle: Eating healthy food that has anti-inflammatory properties can be useful for the body, and finding enjoyable hobbies can be beneficial as well.
Conclusion
Fibromyalgia is a chronic illness that causes pain and inflammation that affects the soft tissue in the body. The symptoms can resemble joint inflammation and causes people to have fatigue and discomfort all over their body. When these symptoms flare up, it can cause body damage. Treatments can help a person reduce the effects of fibromyalgia and be beneficial. Some products are formulated to counter the effects of temporary stress and offer support in the gastrointestinal system and the body�s metabolism.
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues as well as functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or chronic disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at�915-850-0900�.
References:
Felman, Adam. �Fibromyalgia: Symptoms, Causes, and Treatment.� Medical News Today, MediLexicon International, 5 Jan. 2018, www.medicalnewstoday.com/articles/147083.php.
Geenen, Rinie, et al. �Evaluation and Management of Endocrine Dysfunction in Fibromyalgia.� Rheumatic Diseases Clinics of North America, U.S. National Library of Medicine, May 2002, www.ncbi.nlm.nih.gov/pubmed/12122926.
Neeck, G, and L J Crofford. �Neuroendocrine Perturbations in Fibromyalgia and Chronic Fatigue Syndrome.� Rheumatic Diseases Clinics of North America, U.S. National Library of Medicine, Nov. 2000, www.ncbi.nlm.nih.gov/pubmed/11084955.
Staff, Mayo Clinic. �Fibromyalgia.� Mayo Clinic, Mayo Foundation for Medical Education and Research, 11 Aug. 2017, www.mayoclinic.org/diseases-conditions/fibromyalgia/symptoms-causes/syc-20354780.
Staff, Mayo Clinic. �Fibromyalgia.� Mayo Clinic, Mayo Foundation for Medical Education and Research, 11 Aug. 2017, www.mayoclinic.org/diseases-conditions/fibromyalgia/diagnosis-treatment/drc-20354785.
Unknown, Unknown. �Fibromyalgia.� National Institute of Arthritis and Musculoskeletal and Skin Diseases, U.S. Department of Health and Human Services, 30 Sept. 2019, www.niams.nih.gov/health-topics/fibromyalgia.
Wolfe, Frederick, et al. �2016 Revisions to the 2010/2011 Fibromyalgia Diagnostic Criteria.� Seminars in Arthritis and Rheumatism, W.B. Saunders, 30 Aug. 2016, www.sciencedirect.com/science/article/abs/pii/S0049017216302086?via%3Dihub.
Health Coaching is a recent position that is being utilized by doctor offices around the country. Many doctors have realized that their patients are needing more one on one guidance but they are unable to provide this due to their hectic schedule. This is where they have created and utilized health coaches.
Health coaching is extremely beneficial for patients and can help them achieve their health goals. For more information about health coaches and a general overview of the essential role they play in the healthcare field, please see last week’s article linked here.
Health coaches use many different techniques depending on the patient they are working with, but the core values of their methods remain the same. These core values can be broken down into 6 different steps, with each individual step having smaller more detailed steps of their own. These steps can be identified as:
Identifying values and vision
Determining goals
Building a plan for action
Tracking progress
Visualizing one’s best self
Creating a plan for resiliency
Step 1: Identify Values
With this step being the first, it is one of the most crucial. When a patient comes to a physician or a health coach, it is usually because they have been recently diagnosed or are unhappy with their current health status. However, this does not mean that the patient is fully ready to accept their condition or understands it fully.
The patient will be asked to write down inventory in the categories of physical, emotional, spiritual, social, recreational, intellectual, and environmental. The purpose of this is so the patient is able to search and reflect on where they’re currently at and where they would like to be.
From here, there are different techniques and models that a coach may use. One being the transtheoretical model, in which the patient will use stages to move through a behavior change.
At this point, the conversation is less about treatment and more about obtaining an awareness of their health risks, experience with a current illness or any symptoms they�re experiencing. The patient is welcome and encouraged to express their emotions openly. The health coach will move through these next 6 steps to help outline the patient’s treatment and see what stage they are at.
1. Precontemplation: the patient does not intend to take action in the foreseeable future
2. Contemplation: intending to start introducing healthy behaviors within the next 6 months
3. Preparation: patients are ready to take action in the next 30 days
4. Action: the patient has recently changed their behavior and intends to keep moving forward
5. Maintenance: the patient has sustained their behavior change for 6 months and intends to maintain the behavior change for more than six months
6. Termination: the patient has grown and is now self-aware of their behaviors and has no desire to return to their previously unhealthy behaviors
As we all know, values are formed starting in early childhood. These values are then later consciously re-evaluated and may change. It is important for the patient to work with the health coach so they properly understand their personal values. This allows the patient to get clarity and build self-awareness to make intelligent decisions and keep a balance in life.
Actually sitting down identifying values might be difficult, as many individuals do not think about them often. If this is the case, the health coach might help by asking questions like:
What is more important in your life: Beyond basic human needs, what must you have in your life to experience fulfillment?
Take this time and consider a meaningful moment: What was happening to you and what values were you honoring?
Consider a time when you were angry or upset: What were you feeling and, if you flip those feelings around, what value is being suppressed?
These questions aid in triggering times that the patient might not have been connecting to values. After the patient has identifies values, the health coach will work with the patient to select between 5-10 of their core values and then rank them in order of importance. From here, the patient is able to evaluate their values and proceed to determining goals.
Step 2: Determine Goals
Once a patient has identified their values, the health coach will shift their focus and have them brainstorm what they would like to focus on in their healing plan. This step is important because it will determine what they specifically want to change or improve. Some patients may feel unsure or are apprehensive, but allowing the patient time to journal or write out everything they want to accomplish, big or small, as well as the known steps or tasks, will help the patient get there.
When determining goals, the health coach will encourage the patient to create goals for multiple areas in their life. Some of these areas may include, health, family, relationships, and recreation. The health coach will encourage the patient’s goals by having them consider the following questions:
What do I want to achieve?
How will I achieve this goal?
Why do I want to reach this goal?
Who will I need to work with to achieve this goal?
What are the conditions and limitations to achieving this goal?
Based on the core areas and goals, the health coach will work with the patient to determine SMART goals. A SMART goal is a goal-setting technique that brings structure and trackability to goals. SMART goals stand for Specific, Measurable, Attainable, Relevant, and Timely. These create a verifiable trajectory towards a specific objective with clear milestones. By determining SMART goals, it clarifies how and when the goal will be achieved, rather than just stating a desire.
A health coach will help patients turn “I want to lose weight” into ” I want to lose 20 pounds to have more energy to play with my grandchildren. I will do so by exercising four times a week and eating less processed foods, and more fruits and vegetables. I will lose an average of two pounds every week for 10 weeks.”
By doing this, the health coach is working on a goal that immediately interests the patient and puts it into a way that is more attainable. The health coach can help the patient stay encouraged and motivated as they work together to achieve small successes, eventually leading to the patient being more willing to take on bigger challenges.
Using health coaching can be more beneficial than one might originally think. As one can see, they really go deep into one’s life and can help them in ways they might not have planned on originally. In the next article, the steps of building a plan for action and tracking progress and results will be discussed in great detail.
Changing your lifestyle can be difficult and does not happen overnight. Those who work with a coach to reach their goals are more successful and less likely to give up when things get difficult. Coaches are amazing for accountability, advice, health help, goal setting, and organizing expectations in a realistic timeline. Look at it this way: People use a wedding coordinator to help them oragnize food, timelines, expectations, etc. and that is for an event that lasts 1 day. So why are you not using a health coach to help you organize all of these same things for something that will last a lifetime? In addition you’re getting to help decide your future and gain a deeper undestanding of what lies ahead. Investing in yourself is one of the best things you can do for yourself. – Kenna Vaughn, Senior Health Coach
The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or chronic disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.
The information from this article was found in an article written by Integrative Practioner. The sources can be found listed below.
Miller, W. and Rose, G. (1991). Motivational Interviewing: Preparing People to Change Addictive Behavior. Guilford Publications.
Pecoraro, Wendy. �A Six-Step Approach To Health And Wellness Coaching: A Toolkit for Practice Implementation.� Integrative Practitioner.Com, 2019.
Trzeciak, S. and Mazzarelli, A. (2019). Compassionomics. Studer Group. Virginia Polytechnic Institute and State University. The Stages of Change.�Retrieved from: www.cpe.vt.edu/gttc/presentations/8eStagesofChange.pdf
Fact: Chiropractors are known for treating back pain. But they do so much more than that. They are licensed in all fifty states, and there are more than 60,000 practicing chiropractors in America.
Chiropractic treatment is gaining wider acceptance by the medical, legal, and patient communities because of its�beneficial record of positive results and medication-free care.
There have been several studies documenting the safety and effectiveness of chiropractic treatment/care.
Here are some facts and stats about chiropractic medicine.
Chiropractor doing pushing motion to adjust spine of a male patient
Chiropractic Facts
Around 35-40% of chiropractic patients’ reason for treatment involves upper or low back pain.
Chiropractors perform 95.5% of adjustments in the world.
However, people also go to chiropractors for:
Neck pain
Headaches
Vehicle accident injuries
Whiplash
Repetitive motion injuries
Strains
Sports injuries
Chiropractic care helps with rheumatoid arthritis, osteoarthritis or any type of arthritis.
Treatments provided by chiropractors include:
Spinal manipulation/adjustment
Physical therapy
Exercises
Stretches
Massage
Nutrition
Health Coaching
Weight loss
These chiropractic treatments are performed around 1 million times every day.
A chiropractor can be your primary health provider. As they must:
Complete 3 to 4 years of undergraduate education
A 4-year chiropractic college program
Must be licensed by the state they practice in.
The Council on Chiropractic Education (CCE), recognized by the United States Office of Education, is responsible for the accreditation programs and institutions that offer a Doctor of Chiropractic (DC) degree.
Chiropractors do not prescribe medications as part of a treatment plan.
Doctors and physicians can provide referrals or co-workers, friends and family are also positive resources to find the right chiropractor.
Safe Adjustment Facts
A chiropractic adjustment is much safer than taking medications or undergoing surgery. A chiropractic adjustment involves some:
Prep Massage
Stretching
Breathing
Expert help in body realignment
Any type of complication from a chiropractic adjustment is extremely rare.
Does it hurt
Chiropractic adjustments are relatively painless, but new�patients can involuntarily stiffen or resist the adjustment and feel slight discomfort. A qualified chiropractor will know this and wait until the patient relaxes, before continuing the adjustment.
If the patient has recently been involved in some type of trauma, like whiplash from an accident, work, sports, personal injury then there will be pain from the injury. An experienced chiropractor will know how to minimize the pain, as they perform the treatment.
And once it’s over patients feel:
Relief
Improved mobility
Calmness
A sense of well being/euphoria
Can other health professionals also perform these adjustments?
Yes, some osteopaths or DO’s can perform these treatment techniques, but make sure they are state-licensed.
Our team has taken great pride in bringing our families, and injured patients only clinically proved treatment protocols. �By teaching holistic wellness as a lifestyle, we change not only our patient�s lives but their families as well.� We do this so that we may reach as many El Pasoans who need us, no matter the affordability issues.
Sciatica Treatment | El Paso, Tx.
Sciatica is a collection of symptoms characterized by pain which extends down the length of the legs from the lower back.
Approximately 90 percent of sciatica, or sciatic nerve pain, develops when a spinal disc herniation compresses a spinal nerve along the lumbar spine.
Piriformis syndrome and pregnancy are other common causes of sciatica.
NCBI Resources
Fortunately, self-management and time can be the best treatment. Allowing the body to heal itself is the way to go. But if rest is not enough then chiropractic treatment may be just what is needed to kick in the body�s self-healing function. If you decide to give chiropractic treatment a try, don�t be nervous, as a�chiropractor will monitor progress throughout the treatment.
In any case,�chiropractors are qualified to discuss the benefits and risks of other treatments, depending on the condition.
Hopefully, this article has given you the basics of�chiropractic medicine and how it works so you can make the best choice.
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