Back Clinic Functional Medicine Team. Functional medicine is an evolution in the practice of medicine that better addresses the healthcare needs of the 21st century. By shifting the traditional disease-centered focus of medical practice to a more patient-centered approach, functional medicine addresses the whole person, not just an isolated set of symptoms.
Practitioners spend time with their patients, listening to their histories and looking at the interactions among genetic, environmental, and lifestyle factors that can influence long-term health and complex, chronic disease. In this way, functional medicine supports the unique expression of health and vitality for each individual.
By changing the disease-centered focus of medical practice to this patient-centered approach, our physicians are able to support the healing process by viewing health and illness as part of a cycle in which all components of the human biological system interact dynamically with the environment. This process helps to seek and identify genetic, lifestyle, and environmental factors that may shift a person’s health from illness to well-being.
Fruits and vegetables are essential sources of vitamins and minerals. Many groups of these plant-based foods provide the body with fundamental nutrients, where some are richer in several varieties of vitamins and minerals, than others. Many fruits and vegetables also provide the body with important antioxidants. Among these antioxidants, lycopene is abundant in red fruits and vegetables, some of which are crowd favorites.
What are the benefits of lycopene consumption?
Substantial evidence indicates that lycopene, a carotenoid without provitamin A activity found in high concentrations in a small group of plant foods, has significant antioxidant potential in vitro and may play a role in preventing cardiovascular disease as well as prostrate cancer in individuals. Lycopene is believed to possess a cholesterol synthesis-inhibiting effect and might enhance LDL cholesterol, or “bad cholesterol”, degradation. Research studies evaluating its effectiveness in this area can simply answer the question of whether lycopene can help to prevent cardiovascular disease.
Lycopene Intake & Absorption
Lycopene is a� fat-soluble phytonutrient in the carotenoid family which has received attention because of its potential role in preventing cardiovascular diseases. Although similar in construction to the more studied ?-carotene, lycopene doesn’t have provitamin A activity. Carotenoids and their many conjugated double bonds turns them into potentially strong antioxidants, and lycopene is no exception.
Sources include tomatoes, guava, pink grapefruit, watermelon, apricots and papaya in high concentrations. Tomato products, including ketchup, tomato juice, and pizza sauce, are the richest sources of lycopene in the United States diet, accounting for 80 percent of the lycopene consumption of Americans. Tomatoes also contain a significant amount of ?-carotene. In fact, they are the fourth-leading contributor to provitamin A and vitamin A intake in the American diet. Tomatoes are rich in potassium and folate, and there is nearly 3 times as much vitamin C as lycopene in a tomato. In studies of health benefits of tomatoes, an individual has to consider that they are also rich in nutrients aside from lycopene.
Absorption of lycopene’s mechanism isn’t fully understood. Studies have demonstrated that lycopene from tomato products appears in the blood flow when a source of fat is included with the meal and if the tomato is warmed. Plasma lycopene concentrations increased only marginally in a group receiving 180 g tomato juice (containing 12 mg lycopene) per day for 6 weeks. This finding has been supported by research studies demonstrating negligible or only slight increases in plasma lycopene concentrations after consumption of various levels of unheated tomato juice. In one study, nevertheless, when tomato juice was absorbed, serum levels of lycopene increased, with an increase within 24 to 48 hours following ingestion. Gartner et al discovered that concentrations of lycopene from the chylomicrons of 5 human subjects increased 3 times as much when they consumed tomato paste as when they consumed raw tomatoes. Thus, the availability and absorption of lycopene depend on the processing and treatment of the food that contains the carotenoid and on the fat content of the meal in which lycopene is consumed.
Lycopene and Cardiovascular Disease
Several studies examined the connection between dietary intake of antioxidants and lipid peroxidation to attempt to determine which antioxidants may play a role in preventing cardiovascular disease. The hydrocarbon carotenoids, including ?-carotene and lycopene, are transported primarily in LDL cholesterol, which positions them in the prime place to protect LDL cholesterol from oxidation.
Romanchik et al isolated LDL cholesterol samples from 5 individuals and enriched them with ?-carotene, lycopene, and lutein to determine whether this would have an impact on LDL oxidation. On copper-mediated oxidation of the LDL, the carotenoids were destroyed until substantial amounts of lipid peroxidation products were transformed, providing evidence that these pigments might be functioning as antioxidants. Although lycopene was the most quickly destroyed of the carotenoids studied, only the LDL cholesterol samples enriched with ?-carotene exhibited increased CD lag time. In another study of LDL from 11 different people, the same researchers actually found increased oxidation of LDL (as quantified by the ferrous oxidation, xylenol orange assay) on enrichment with lycopene and lutein, signaling that the connection between lycopene and LDL cholesterol oxidation is complicated.
Lycopene creates a significant reduction in serum lipids, blood pressure and oxidative stress markers. Paran et al evaluated 30 subjects with Grade I hypertension, age 40 to 65, taking no anti-hypertensive or anti-lipid drugs, treated with a tomato lycopene extract (10 mg lycopene) for 2 weeks. The SBP was reduced from 144 to 135 mmHg (9 mmHg decrease, p < 0.01) and DBP fell from 91 to 84 mmHg (7 mmHg decrease, p < 0.01). Similar results were shown by another analysis of 35 subjects with Grade I hypertension on SBP, but not DBP. Englehard gave a tomato extract to 31 subjects over 12 weeks demonstrating that a significant BP reduction of 10/4 mmHg. Patients on various anti-hypertensive agents including ACEI, CCB and diuretics experienced a significant blood pressure decrease of 5.4/3 mmHg more than 6 weeks when administered a standardized tomato extract. Other research studies haven’t shown changes in blood pressure. Lycopene and tomato infusion improve ED and reduced plasma oxidative stress.
An intriguing nonantioxidant purpose of lycopene was revealed in humans. Fuhrman et al revealed that cholesterol synthesis was decreased by the addition of lycopene to macrophage cell lines and increased LDL cholesterol receptors. Incubation with lycopene in vitro led to a 73 percent reduction in cholesterol synthesis, which has been higher than that achieved with ?-carotene. Additionally, lycopene led to a 34 percent growth in LDL degradation in the cells themselves and approximately a 110 percent increase in the removal of LDL cholesterol in the blood flow. To test their findings in humans, the investigators fed 6 men with 60 milligrams of lycopene per day for 3 weeks (approximately equivalent to the total amount of lycopene in 1 kg tomatoes). They discovered that a decrease in plasma LDL cholesterol with no significant change in HDL cholesterol. Based on the calculations of Peto et al that there is a 3:1 ratio involving the decreased risk of myocardial infarction, where a 30 percent to 40 percent risk reduction in individuals consuming this amount of lycopene. The recommended daily intake of lycopene is approximately 10 to 20 mg in supplement or food form.
Lycopene, along with other antioxidants, are fundamental towards the prevention of cardiovascular disease. When levels of LDL cholesterol, or “bad cholesterol” are out of balance, red fruits and vegetables, rich in lycopene, can help improve overall heart health, according to research studies. The scope of our information is limited to chiropractic and spinal injuries and conditions. To discuss the subject matter, please feel free to ask Dr. Jimenez or contact us at 915-850-0900 .
By Dr. Alex Jimenez
Additional Topics: Wellness
Overall health and wellness are essential towards maintaining the proper mental and physical balance in the body. From eating a balanced nutrition as well as exercising and participating in physical activities, to sleeping a healthy amount of time on a regular basis, following the best health and wellness tips can ultimately help maintain overall well-being. Eating plenty of fruits and vegetables can go a long way towards helping people become healthy.
Diets high in flavonoids have been associated with a way of life, as it’s often a part of many nutritional recommendations from healthcare professionals associated with the prevention of chronic diseases. However, the identification of beneficial effects from flavonoids and flavonoid-rich foods has become a difficult area to discuss due to a conditional or non-essential role of flavonoids in human nourishment, according to some research.
Do flavonoids help reduce the risk of cardiovascular disease?
Nonetheless, recent attempts to otherwise prove this in the medical field surrounding cardiovascular disease as well as efforts in the area of high flavonoid containing foods, have started supplying the demonstrations of effects and mechanisms of action in well-controlled research studies. Further studies are essential for confirmation of the effects and for the proper identification of bioactive flavonoids in relation to cardiovascular diseases.
Flavonoids and Cardiovascular Disease
Epidemiological studies, clinical trials and basic science has found an inverse correlation between flavonoid intake and a decreased mortality from the prevalence of stroke and coronary heart disease, including the improvement of hypertension and cardiovascular disease risks.
More than 4000 naturally occurring flavonoids have been identified, including fruits, vegetables, red wine, tea, soy and licorice. Flavonoids (flavonols, flavones and isoflavones) are potent free radical scavengers that inhibit lipid peroxidation, prevent atherosclerosis, promote vascular relaxation and also have anti-hypertensive properties. Along with reducing stroke and providing effects which reduce mortality and CHD morbidity, as mentioned.
Many mechanisms have been suggested to explain the protective effects of flavonoids in relation to cardiovascular diseases:
Antiatherogenic effects. Flavonoids along with other antioxidants, comprise two lines of defense in protecting cells from harm because of oxidation of LDL cholesterol; First, in the LDL blood cholesterol level, by inhibiting LDL oxidation because of their free radical scavenger activity, and second, in the cellular level, by shielding the cells accordingly, i.e., by raising their resistance against the cytotoxic effect of oxidised LDL. Recent research studies suggest that flavonoids may additionally help stop the expression of adhesion and chemoattractant molecules.
Antiaggregant effects. Flavonoids avoid platelet aggregation triggered by numerous pro-aggregant stimuli although high doses are required. Inhibition of platelet phosphodiesterases, inhibition of arachidonic acid metabolism and antioxidant effects have been suggested as potential mechanisms of action.
Direct effects on vascular smooth muscle. The vasodilator effects of flavonoids in vitro is endothelium-independent. The most important mechanism appears to be related to their inhibitory effects on protein kinases. Some flavonoids, though, can produce endothelium-dependent contractile reactions due to increased TXA2, or thromboxane A2, production.
Anti-hypertensive results.�Only small amounts of information concerning the effects of flavonoids on blood pressure have been obtained. However, recently, the oral administration of quercetin has been shown to exert potent anti-hypertensive effects
Resveratrol is a potent antioxidant and anti-hypertensive, found from red wine and in the skin of grapes. Administration to individuals enhances compliance, reduces enhancement indicator and enhances blood pressure when administered as 250 mL of either�regular or de-alcoholized red wine. There was a substantial reduction in the aortic augmentation index of 6.1 percent together with all the de-alcoholized red wine and 10.5 percent with regular red wine. The central blood pressure was significantly reduced by de-alcoholized red wine in 7.4 mmHg and 5.4 mmHg by routine red wine. Resveratrol improves ED circulation mediated vasodilation at a dose related manner, prevents uncoupling of eNOS, increases adiponec-tin, lowers HS-CRP and blocks the effects of angiotensin II. The suggested dose is 250 mg/d of transresveratrol.
Research on CVD and Flavonoids
Basic science, clinical monitoring, and a variety of research studies, have all led to an emerging body of evidence on the role of flavonoids, at the prevention of cardiovascular disease. However, the existing studies on flavonoids or its food resources have provided contradictory results,�generally on the primary prevention of coronary heart disease mortality. The study used the grant mechanism to analyze data that was previously collected.
The researchers examined whether flavonoid intake was associated with the risk of incident cardiovascular disease and whether specific food sources of flavonoids, including onions, tea, apples, red wine, along with other foods, have been related to the risk of CVD and hypertension. The researchers processed and examined previously collected statistics of 39,876 middle-aged and elderly girls free of CVD; the Women’s Antioxidant Cardiovascular Study (WACS), a prospective study of 8,171 middle-aged and older women with preexisting CVD or over three coronary risk factors; the Normative Aging Study (NAS), a prospective study of 2,280 middle-aged and elderly men; along with the Boston Area Health Study (BAHS), a case-control study of first nonfatal myocardial infarction in women and men aged less than 76 decades. Utilizing data from semiquantitative food frequency questionnaires administered in every study, the investigators determined individual intake of flavonoids and its food sources.
Unlike previous studies, researchers have examined flavonoids in relation to both primary and secondary prevention of cardiovascular disease, comprising verified cases of nonfatal myocardial infarction (Ml), nonfatal stroke, revascularization procedures, and death. The scope of our information is limited to chiropractic and spinal injuries and conditions. To discuss the subject matter, please feel free to ask Dr. Jimenez or contact us at 915-850-0900 .
By Dr. Alex Jimenez
Additional Topics: Wellness
Overall health and wellness are essential towards maintaining the proper mental and physical balance in the body. From eating a balanced nutrition as well as exercising and participating in physical activities, to sleeping a healthy amount of time on a regular basis, following the best health and wellness tips can ultimately help maintain overall well-being. Eating plenty of fruits and vegetables can go a long way towards helping people become healthy.
The increased risk of cardiovascular disease has been frequently attributed to an improper diet and nutrition. Foods high in saturated and trans fats, for example, can substantially raise the levels of “bad cholesterol” in the body, which may then lead to high blood pressure and cardiovascular disease. While vitamin and mineral deficiencies as well as the improper intake of other important compounds, like amino acids, have been linked to CVD, several research studies have found that fiber can have a tremendous influence in the risk of cardiovascular disease.
How does fiber help lower the risk of cardiovascular disease?
Abnormal levels of cholesterol, medically recognized as LDL and HDL cholesterol, can develop into fatty deposits within the blood vessels. Over time, these deposits can make it difficult for enough blood to circulate through the arteries. The�heart may not get as much oxygen-rich blood as it needs, which then increases the risk of cardiovascular. But, can fiber prevent cardiovascular disease? Before covering how fiber can improve the risk of developing cardiovascular disease, we must first understand what fiber is and what role it plays in the human body.
Many different definitions of fiber have been created to-date. In an attempt to create a single definition of fiber that everyone can utilize, the Nutrition and Food Board constructed a panel that came up with the following definitions:
Dietary fiber consists of non-digestible carbohydrates and lignin that are intrinsic and intact in plants. This includes plant non-starch polysaccharides (by way of example, cellulose, pectin, gums, hemicellulose, and fibers inside oat and wheat bran), oligosaccharides, lignin, and several forms of resistant starch.
Functional fiber consists of isolated, non-digestible carbohydrates which are beneficial in humans. These include non-digestible plant (for instance, resistant starch, pectin, and gums), chitin, chitosan, or commercially generated (by way of example, resistant starch, polydextrose, inulin, and indigestible dextrins) carbohydrates.
Total fiber is the sum of dietary fiber and functional fiber. It’s not important to differentiate between which types of the fibers you are getting in your daily dietary and nutritional program. Your total fiber intake is what matters.
Whichever definition is the most suitable to each individual, remember that fiber is an essential part of everyone’s diet. While fiber does fall under the category of carbohydrates, in comparison, it does not provide the same number of calories, nor is it processed the way that other sources of carbohydrates are. Fiber, however, can be further classified as soluble or insoluble.
Soluble Fiber
Soluble fibers have the ability to swell and hold water.
When eaten as part of a diet low in saturated and trans fats, soluble fiber has been associated with an increased diet quality as well as the reduced risk of developing cardiovascular disease.
Soluble fiber modestly reduces LDL (“bad”) cholesterol past levels attained by a diet low in saturated fats and trans fats alone.
Oats have a larger proportion of soluble fiber compared to any other grain.
Insoluble Fiber
Insoluble fiber has been associated with decreased and slower progression of cardiovascular disease in high-risk individuals.
Most other grains, rye, rice, and wheat are composed of insoluble fiber.
Legumes, beans, and peas can also be excellent sources of both soluble and insoluble fiber. Certain fruits and vegetables are better sources of both insoluble and soluble fiber compared to others. Many processed oat bran and wheat bran products (for instance, muffins, chips, waffles) could be made out of refined grains, perhaps not the entire grain. They can be high in sodium, added sugars and saturated fat. Make sure to read labels carefully.
Fiber for Preventing Cardiovascular Disease
In order to help decrease the risk of cardiovascular disease, many health care professionals recommend adhering to a high-fiber diet to improve your overall heart health. Studies have produced evidence to support this. At a Harvard study of over 40,000 health professionals, it was found that a high total dietary fiber intake was linked to a 40 percent lower risk of coronary heart disease, or CHD, compared to a low-fiber intake. Another study of over 31,000 California Seventh-day Adventists found a 44 percent reduced risk of nonfatal coronary heart disease and an 11 percent reduced risk of fatal coronary heart disease for those who ate whole-wheat bread compared with those who ate white bread.
Another predictor of cardiovascular disease is blood sugar, along with LDL and HDL cholesterol levels. It seems that soluble fiber reduces the absorption of cholesterol into the intestines by binding with bile (which includes cholesterol) and dietary cholesterol so that the body excretes it. Bran fiber intervention trials in which fiber supplementation was combined with a low-fat diet and the oat bean shows that reductions in cholesterol levels ranged from 8 to 26 percent. Other studies have revealed that 5 to 10 grams of fiber per day decreases LDL cholesterol by about 5 percent. Each of these advantages will happen no matter of the fluctuations in dietary fat consumption. In a trial with low fat and low fat plus high fiber groups, the group consuming high fiber exhibited a greater average reduction (13%) in total cholesterol concentration than the low fat (9%) and the usual diet (7%) groups.
The clinical trials with many sorts of fiber are inconsistent, however, when it comes to decreasing high blood pressure. Soluble fiber, guar gum guava, psyllium and oat bran can decrease blood pressure and lower the need for medication in hypertensive subjects locations and subjects. The typical reduction in BP is about 7.5/5.5 mmHg on 40 to 50 g/d of a mixed fiber. There is development in sodium loss, improvement in insulin sensitivity, endothelial function and decrease in the sympathetic nervous system activity.
Finding the Right Fiber Intake
The daily consumption of fiber from the typical American is about 5 to 14 grams every day. The American Heart Association, or the AHA, recommends that to an adequate intake of fiber should be based on the individual’s gender and age. The daily value for fiber is 25 grams of fiber each day for a 2,000 calorie diet. The AHA recommends getting fiber from foods rather than from fiber supplements.
Serving Size
In accordance with the American Heart Association, the next count as 1 ounce-equivalent (or 1 serving) of whole grains:
1 slice whole-grain bread (such as 100% whole-wheat bread)
1 cup ready-to-eat, whole-grain cereal
1?2 cup cooked whole-grain cereal, brown rice, or whole-wheat pasta
5 whole-grain crackers
3 cups unsalted, air-popped popcorn
1 6-inch whole-wheat tortilla
Fiber should be a part of a balanced diet and nutrition. Following the best dietary and nutritional plans can help improve overall heart health, substantially helping to decrease the risk of cardiovascular disease. Fiber can help reduce the levels of “bad cholesterol” in the body, balancing overall blood cholesterol to improve blood circulation and prevent CVD complications. The scope of our information is limited to chiropractic and spinal injuries and conditions. To discuss the subject matter, please feel free to ask Dr. Jimenez or contact us at 915-850-0900 .
By Dr. Alex Jimenez
Additional Topics: Wellness
Overall health and wellness are essential towards maintaining the proper mental and physical balance in the body. From eating a balanced nutrition as well as exercising and participating in physical activities, to sleeping a healthy amount of time on a regular basis, following the best health and wellness tips can ultimately help maintain overall well-being. Eating plenty of fruits and vegetables can go a long way towards helping people become healthy.
The American Heart Association, or the AHA, has had a consistent, long-standing focus towards providing the public with the necessary information regarding the role of nutrition reducing the risk of cardiovascular disease. Periodic AHA Dietary Guidelines�support a dietary pattern that promotes the consumption of fruits, vegetables, whole grains, low-fat or nonfat dairy products, fish, legumes, poultry, and lean meats. An improper nutrition consisting of foods rich in saturated and trans fats, can raise the human body’s “bad” cholesterol levels, increasing the risk of cardiovascular disease.
How can vitamins improve the risk of cardiovascular disease?
The American Heart Association’s Dietary Guidelines can help with weight control as well as provide a high nutrient density to meet all nutritional needs.�As reviewed in the first AHA Science Advisory, epidemiological and population studies reported that some vitamins, such as vitamin C, vitamin E, vitamin D and vitamin B6 (pyridoxine), may beneficially affect cardiovascular disease. Reducing the overall risk of cardiovascular disease�can be achieved by the long-term consumption of dietary patterns consistent with the AHA Dietary Guidelines. Vitamin C, vitamin E, vitamin D and vitamin B6 (pyridoxine), each perform a specific function in the prevention and improvement of CVD. The following are described in detail, below.
Vitamin C
Vitamin C is a powerful water-soluble electron-donor. At physiologic levels, it is an antioxidant, although at supra-physiologic doses such as those achieved with intravenous vitamin C, it donates electrons to different enzymes in a pro-oxidative effect. At physiologic doses, vitamin C recycles vitamin E, improves ED and produces a diuresis. Intake of vitamin C and plasma ascorbate concentration in humans is related to heart rate, DBP and SBP.
A review of clinical trials suggest that vitamin C dosing in 250 mg twice daily will lower SBP 5-7 mmHg and diastolic BP 2-4 mmHg in more than 8 weeks. Vitamin C may give rise to a sodium water diuresis, enhance nitric oxide, improve endothelial function, increase nitric oxide and PGI2, decrease adrenal hormone production, improve sympathovagal balance, boost RBC Na/K ATPase, boost SOD, improve aortic elasticity and elasticity, enhance circulation conducive vaso-dilation, reduce pulse wave speed and augmentation index, raise cyclic GMP, trigger potassium channels, reduce cytosolic calcium and reduce serum aldehydes. Vitamin C prevents ED, decreasing the binding affinity of the AT 1 receptor for angiotensin II by disrupting the disulfide bridges, it enriches the antihypertensive effects of drugs and medications in the elderly with hypertension. In patients with hypertension already on maximum pharmacologic therapy, 600 mg of vitamin C lowered the BP in 20/16 mmHg. The lower the first ascorbate serum amount, the greater the blood pressure response. A serum level of 100 ?mol/L is recommended. The SBP and 24 ABM reveal the most important reductions with chronic oral administration of Vitamin C. Block et al within an elegant depletion-repletion study of vitamin C revealed an inverse correlation of plasma ascorbate levels, SBP and DBP. At a meta-analysis of thirteen clinical trials jointly with 284 patients, vitamin C in 500 mg/d in more than 6 weeks decreased SBP 3.9 mmHg and DBP 2.1 mmHg. Hypertensive individuals were found to have significantly lower plasma ascorbate levels in comparison with normotensive subjects (40 ?mol/L vs 57 ?mol/L respectively), and plasma ascorbate is inversely correlated with BP even in healthy, normotensive individuals.
Vitamin E
Most studies have not shown reductions in BP with most forms of tocopherols or tocotrienols.. Patients with T2DM and controlled hypertension (130/76 mmHg) on prescription drugs and medications with an average blood pressure of 136/76 mmHg were administered mixed tocopherols containing 60 percent gamma, 25 per cent delta and 15 percent alpha tocopherols. The BP really increased by 6.8/3.6 mmHg in the research patients (de < 0.0001) but was significantly less compared to this growth with alpha tocopherol of 7/5.3 mmHg (p< 0.0001). This might be a reflection of drug interactions with tocopherols via cytochrome P 450 (3A4 and 4F2) and reduction in the serum levels of the pharmacologic therapy treatments that were concurrently being granted to the patients. Gamma tocopherol could have natriuretic effects by inhibition of this potassium channel in the thick ascending limb of the loop of Henle and reduced BP. Insulin sensitivity improves and enhances adiponectin expression through gamma dependent procedures, which have the potential to serum glucose and lower BP. When vitamin E has an effect, it is most likely small and might be restricted to those with cardiovascular disease or untreated hypertensive patients or psychiatric problems, such as hyperlipidemia or diabetes.
Vitamin D
Vitamin D3 may have an independent and immediate role in the regulation of insulin metabolism and BP. Blood pressure, with its consequences, affects the RAA system, control of adrenal glands, immune system, calcium-phosphate metabolism and ED. The circulating PRA amounts are higher which increases angiotensin II if the vitamin D degree is below 30 ng/mL, increases BP and blunts plasma renal blood flow. The lower the degree of vitamin D, the greater the chance of hypertension, with the lowest quartile of serum Vitamin D with an incidence of hypertension in addition to the maximum quartile. Vitamin D3 markedly suppresses renin transcription. Its function in quantity, electrolytes and BP homeostasis indicates that Vitamin D3 is important in amelioration of hypertension. Vitamin D lowers ADMA, suppresses pro-inflammatory cytokines for example TNF-?, raises nitric oxide, improves endothelial function and arterial elasticity, decreases vascular smooth muscle hypertrophy, modulates electrolytes and blood glucose, increases insulin sensitivity, reduces free fatty acid concentration, regulates the expression of the natriuretic peptide receptor additionally reduces HS-CRP.
The hypotensive effect of vitamin D has been inversely related to the pretreatment serum levels of 1,25(OH)2D3and additive to antihypertensive drugs and medications. Pfeifer et al revealed that supplementation with vitamin D3 and calcium is more effective in reducing SBP. In a study, 148 women with low 25(OH)2D3 levels, the management of 1200 mg calcium and 800 IU of vitamin D3 decreased SBP 9.3 percent more (p< 0.02) in comparison to 1200 mg of calcium alone. The HR fell 5.4 percent (p = 0.02), but DBP wasn’t changed. The scope in BP reduction was 3.6/3.1 to 13.1/7.2 mmHg. The reduction in BP is about serum level of vitamin D3, the dose of vitamin D3 and the level of vitamin D3, but BP is reduced only in patients. Although vitamin D deficiency is associated with hypertension in observational studies, their meta-analysis and randomized clinical trials have yielded inconclusive results. Vitamin D receptor gene polymorphisms may effect the risk of hypertension. A 25 hydroxyvitamin D level of 60 ng/mL is suggested.
Vitamin B6 (Pyridoxine)
Low serum vitamin B6 (pyridoxine) levels are linked to hypertension in several individuals. One research study conducted by Aybak et al demonstrated that blood pressure was significantly reduced by high dose vitamin B6 at 5 mg/kg daily for 4 wk by 14/10 mmHg. Pyridoxine (vitamin B6) is a cofactor in neurotransmitter and hormone synthesis in the central nervous system(norepinephrine, epinephrine, serotonin, GABA and kynurenine), raises cysteine synthesis to neutralize aldehydes, improves the production of glutathione, blocks calcium channels, enhances insulin resistance, reduces central sympathetic tone and reduces end organ responsiveness to glucocorticoids and mineralo-corticoids. Vitamin B6 is decreased using pyrollactams and chronic therapy. Vitamin B6 has actions to diuretics alpha agonists and CCB’s. The proposed dose is 200 mg/d orally.
In conclusion, individuals with cardiovascular disease can benefit from the proper diet and nutrition. Essential vitamins found in the dietary patterns provided by the American Heart Association’s Dietary Guidelines can ultimately help reduce and prevent the risk of cardiovascular disease as well as help improve overall heart health. An improper nutrition consisting of foods rich in saturated and trans fats can increase the prevalence of cardiovascular disease. While diagnosis and drugs/medications can be prescribed to treat cardiovascular disease, a balanced nutrition can have similar effects.� The scope of our information is limited to chiropractic and spinal injuries and conditions. To discuss the subject matter, please feel free to ask Dr. Jimenez or contact us at 915-850-0900 .
By Dr. Alex Jimenez
Additional Topics: Wellness
Overall health and wellness are essential towards maintaining the proper mental and physical balance in the body. From eating a balanced nutrition as well as exercising and participating in physical activities, to sleeping a healthy amount of time on a regular basis, following the best health and wellness tips can ultimately help maintain overall well-being. Eating plenty of fruits and vegetables can go a long way towards helping people become healthy.
Since the original American Heart Association, or the AHA, Science Advisory was published in 1996, several fundamental new findings have been reported about the benefits of omega fatty acids on cardiovascular disease, CVD, particularly that of omega-3 fatty acids.�The evidence supporting the clinical benefits of omega fatty acids and CVD comes from a variety of research studies as well as randomized, controlled trials.
How are omega fatty acids beneficial for cardiovascular disease?
Large-scale epidemiologic studies suggest that people at risk for coronary heart disease, or CHD, benefit from consuming omega-3 fatty acids from plants and marine sources. Further research studies suggest that both omega 3 and omega 6 fatty acids are most essential towards improving heart health, although omega-9 fatty acids also provide beneficial properties for individuals with CVD, CHD and hypertension.
Omega-3 & Omega-6 Fatty Acids
The omega-3 fatty acids found in cold water fish, fish oils, flax, flax seed, flaxseed oil and nuts demonstrated they could lower blood pressure, or BP, obser-vational, epidemiologic and in prospective clinical trials The findings improved in response to hypertension and other cardiovascular diseases.
Studies indicate that DHA at 2 g/d reduces BP and heart rate. The reduction in BP is 8/5 mmHg and roughly 6 beats/min drops generally. Fish oil in 4-9 g/d or mix of DHA and EPA in 3-5 g/d may also lessen BP. However, the production of EPA and eventually DHA from ALA decreases in the presence of large LA (the crucial omega-6 fatty acid), saturated fats, trans fatty acids, alcohol, and several nutrient deficiencies (magnesium, vitamin B6) as well as aging, all of which inhibit the desaturase enzymes.) For reducing BP in hypertensive patients, eating cold water fish each week may be as effective as high dose fish oil, and the protein in the fish might provide additional beneficial effects. In patients with chronic kidney disease, for example, 4 g of omega-3 fatty acids decreased BP measured with 24 hours ABM over 8 weeks from 3.3/2.9 mmHg, compared to placebo (p < 0.0001).
The perfect ratio of omega-6 FA into omega-3 FA is between 1:1 to 1:4 with a polyunsaturated to saturated fat ratio greater than 1.5 to 2:0. ENOS while nitric oxide increases, improving function, enhancing insulin sensitivity to suppress ACE activity, reduce calcium spike and improve parasympathetic tone. The FA family includes GLA, LA, dihomo-GLA and AA, which generally do not considerably lower blood pressure, however, it might stop increases in BP. GLA can obstruct hypertension by reducing levels raising PGE1 and PGI2, reducing affinity and AT1R density.
The omega-3 FA possess a large number of additional effects that modulates reduction of ACE activity, growth in ED, reduction in plasma nor-epinephrine and boost in parasympathetic tone. Blood pressure, for instance, increases in nitric oxide and eNOS for the improvement of insulin resistance. The recommended daily dose is 3000 to 5000 mg/d of combined DHA and EPA in a ratio of 3 parts EPA to two parts DHA and roughly 50 percent of the dose as GLA along with gamma/delta tocopherol at 100 mg per gram of DHA and EPA to find the omega-3 index to 8 percent or higher to decrease BP and provide optimum cardioprotection. DHA is more effective than EPA and must be awarded at two g/d if administered independently.
Omega-9 Fatty Acids
Olive oil is abundant in the omega-9 monounsaturated fat (MUFA) lactic acid, that has been associated with BP and lipid decrease in Mediterranean diets and in other types of diets. MUFAs and olive oil show reductions in BP. In a single study, the SBP fell 8 mmHg (p? 0.05) and the DBP fell 6 mmHg (p? 0.01) at the practice and 24 hour ambulatory BP monitoring in the MUFA treated subjects compared to this PUFA handled issues. Additionally, the requirement for antihypertensive drugs was reduced by 48 percent in the MUFA group vs 4 per cent at the omega-6 PUFA group (de < 0.005).
Extra virgin olive oil (EVOO) was more powerful than sunflower oil in lowering SBP at a group of 31 elderly hypertensive patients in a double blind randomized cross-over study. The SBP has been 136 mmHg from the EVOO treated subjects vs 150 mmHg in the sunflower treated group (p < 0.01). Olive oil also reduces BP in diabetic subjects. It is the high oleic acid content in oil which reduces BP. In stageIhypertensive sufferers, oleuropein-olive leaf (Olea Eurpoaea) extract 500 mg bid for 8 wk decreased BP 11.5/4.8 mmHg which was similar to captopril 25 mg bid. Olea Eupopea L aqueous infusion administered to 12 patients using hypertension in 400 mg qid for 3 mo significantly reduced BP (p < 0.001). Oil ingestion in the EPIC study of 20343 subjects was associated with both systolic and diastolic BP. In sunlight analysis of 6863 areas, BP was inversely associated with olive oil consumption, but just in males. At doses of 500 to 1000 in comparison to placebo leaf extract demonstrated a dose response reduction in a study of 40 hypertensive twins.
The very low dose groups diminished BP 3/1 mmHg and the dose 11/4 mmHg. A double blind, randomized, crossover dietary intervention study over 4 mo using polyphenol rich olive oil 30 mg/d decreased BP in the study group by 7.91/6.65 mmHg and improved endothelial function. OxLDL, the ADMA levels and HS-CRP were decreased in the olive oil group. Plasma nitrites and nitrates improved and region after ischemia improved in the treated group. Jojoba oil exerts calcium channel antagonist impacts inhibits the receptor that is AT1R and enhances wave reflections and augmentation index. EVOO is also contains lipid-soluble phytonutrients such as polyphenols. Approximately 5 mg of phenols are found in 10 g of EVOO. About 4 tablespoons of EVOO is equivalent to 40 gram of EVOO that’s the overall necessary to get substantial reductions.
In conclusion, research studies and randomized, controlled trials,�have convincingly documented that omega fatty acids can significantly reduce the occurrence of cardiovascular disease, CHD and hypertension. Additional clinical studies are needed to confirm the� benefits of omega fatty acids. A food-based approach to increasing omega-3-6-9 fatty acids is preferable, although supplements are a suitable alternative. Additional clinical and mechanistic studies are needed to confirm and further define the health benefits of omega fatty acids for both primary and secondary prevention.
The scope of our information is limited to chiropractic and spinal injuries and conditions. To discuss the subject matter, please feel free to ask Dr. Jimenez or contact us at 915-850-0900 .
By Dr. Alex Jimenez
Additional Topics: Wellness
Overall health and wellness are essential towards maintaining the proper mental and physical balance in the body. From eating a balanced nutrition as well as exercising and participating in physical activities, to sleeping a healthy amount of time on a regular basis, following the best health and wellness tips can ultimately help maintain overall well-being. Eating plenty of fruits and vegetables can go a long way towards helping people become healthy.
Among the numerous risk factors which can lead to cardiovascular disease and hypertension, dietary and nutritional imbalances are among some of the most prevalent causes behind heart health issues, according to various research studies. While vitamin and mineral deficiencies have been commonly linked to the development of CVD and hypertension, other related compound deficiencies may be just as important towards heart health.
What’s the significance between amino acids and cardiovascular disease?
Many research studies have found a fundamental correlation between the proper intake of amino acids and cardiovascular disease, as well as the increased risk of hypertension. As previously discussed, protein plays a crucial role in almost all biological processes and amino acids are the building blocks of it.�A large proportion of our cells are made up of amino acids, meaning they carry out many important bodily functions, such as giving cells their structure as well as transporting and storing nutrients. Amino acids have an influence on the function of organs, glands, tendons and arteries.
Amino Acids for Cardiovascular Disease
Researchers believe that almost every disease is the result of imbalances to our metabolism and amino acids are mainly responsible for achieving a balanced metabolism.�The objective is that there is a complete amino acid content, maintained in the correct combination. If the one or more amino acids are not available in sufficient quantities, the production of protein is weakened and the metabolism may only function in a limited way. The following are several of the amino acids necessary to sustain overall health and wellness, improving the risk of cardiovascular disease and hypertension.
L-Arginine
L-arginine and endogenous methylarginines are the precursors for the production of NO, or nitric oxide, which has beneficial cardiovascular effects, mediated through conversion of L-arginine to nitric oxide, or NO from eNOS. Patients with hypertension, hyperlipidemia, diabetes mellitus and atherosclerosis have increased levels of HSCRP and inflammation, greater microalbumin, low levels of apelin (stimulates NO in the endothelium), elevated amounts of arginase (breaks down arginine) and increased serum levels of ADMA, which inactivates NO.
Under normal physiological conditions, intracellular arginine levels significantly exceed the Km of eNOS that is less than 5 ?mol. But, endogenous NO formation is dependent on extracellular arginine concentration. The intracellular concentrations of L-arginine are 0.1-3.8 mmol/L in endothelial cells while the plasma concentration of arginine is 80-120 ?mol/L that is about 20-25 times greater than the MMC. Despite this, mobile NO formation depends on exogenous L-arginine and this really is actually the paradox. Arginine can be a more powerful antioxidant and blocks the formation of endothelin, reduces renal sodium reabsorption and modulates BP. The NO production in endothelial cells is closely coupled to arginine uptake indicating that transport mechanics play a significant part in the regulation of function. Arginine can raise vascular and NO bioavailability and influence perfusion, function and BP. Molecular eNOS might occur in the absence of tetrahydrobiopterin which stabilizes eNOS, which leads to production of ROS.
Individual studies in hypertensive and normotensive subjects of L-arginine of parenteral and oral administrations demonstrate an antihypertensive effect as well as progress in coronary artery blood flow and peripheral blood circulation in PAD. The BP decreased by 6.2/6.8 mmHg on 10 g/d of L-arginine when provided as a nutritional supplement or even organic foods to a group of hypertensive subjects. Arginine produces a significant decrease in BP and improved impact in normotensive and hypertensive individuals that is comparable in magnitude to that plan. Arginine awarded in g/d also significantly reduced BP in women with gestational hypertension without proteinuria, decreased the demand for anti-hypertensive therapy, decreased maternal and neonatal complications and protracted the maternity. The combination of arginine (1200 mg/d) and N-acetyl cysteine (NAC) (600 mg bid) administered over 6 mo to hypertensive patients with type 2 diabetes, lowered SBP and DBP (p < 0.05), greater HDL-C, diminished LDL-C and oxLDL, decreased HSCRP, ICAM, VCAM, PAI-I, fibrinogen and IMT. An analysis of 54 hypertensive subjects given grams three times every day for four weeks had significant reductions in 24 h ABM. A meta-analysis of 11 trials with 383 subjects administered arginine 4-24 g/d discovered average reduction in BP of 5.39/2.66 mmHg (p < 0.001) in 4 wk. Although these doses of L-arginine seem to be secure, no long term studies in humans have been released at this time and there are worries of a pro-oxidative influence or even an increase in mortality in individuals who might have severely dysfunctional endothelium, advanced atherosclerosis, CHD, ACS or MI. In addition to the path, there is an pathway that is connected to nitrates out of berries, beetroot juice along with the DASH diet which are converted into nitrites by salivary symbiotic, GI and oral bacteria. Administration of extract or beetroot juice at 500 mg/d improve endothelial function and lower BP, increases nitrites, increase peripheral, coronary and cerebral blood flow.
L-Carnitine and Acetyl-L-Carnitine
L-carnitine is a nitrogenous muscle. Animal studies suggest that carnitine has both hereditary anti-hypertensive effects and anti-oxidant consequences in the heart by up-regulation of both eNOS and PPAR gamma, inhibition of RAAS, modulation of NF-?B and down regulation of NOX2, NOX4, TGF-? and CTGF that reduces vascular fibrosis. While BP and cognitive stress are reduced, endothelial NO function and oxidative defense are improved.
Studies on the effects of L-carnitine and acetyl-L-carnitine are limited. In patients with MS, acetyl-L-carnitine, improved dysglycemia and decreased SBP from 7-9 mmHg, but diastolic BP was significantly decreased only in people with sugar. Low amounts are correlated with a nondipping BP routine in Type 2 DM. Carnitine might be beneficial in the treatment of essential hypertension, type II DM with hyperlipidemia, hypertension, cardiac arrhythmias, CHF and cardiac ischemic syndromes and has anti-inflammatory and antioxidant results. Doses of 2-3 grams per day are recommended.
Taurine
Taurine is a sulfonic acid that is regarded as a conditionally-essential amino acid, which is not used in protein synthesis, but is located free or in easy peptides with its concentration in the brain, retina and myocardium. In cardiomyocytes, it has a role of inotropic factor, an osmoregulator and agent and reflects approximately 50 percent of the amino acids.
Human studies have noted that essential hypertensive subjects have reduced urinary taurine as well as other sulfur amino acids. Taurine lowers BP, SVR and HR, reduces arrhythmias, CHF symptoms and SNS activity, raises urinary sodium and water excretion, raises atrial natriuretic factor, improves insulin resistance, raises NO and improves endothelial function. Taurine also decreases A-II, PRA, aldosterone, SNS activity, plasma norepinephrine, plasma and urinary epinephrine, lowers homocysteine, enhances insulin sensitivity, kinins and acetyl choline responsiveness, reduces intracellular sodium and calcium, reduces reaction to beta receptors and has antioxidant, anti-atherosclerotic and anti-inflammatory activities, reduces IMT and arterial stiffness and may shield from risk of CHD. There is A urinary taurine associated with greater risk of CVD and hypertension. A study of 31 males with hypertension showed a 26 percent increase in taurine levels and also a 287 percent growth in cysteine levels. The BP reduction of 14.8/6.6 mmHg was proportional to increases in serum taurine and discounts in plasma norepinephrine. Fujita et al revealed a reduction in BP of 9/4.1 mmHg (p< 0.05) in 19 hypertension issues given 6 grams of taurine for 2 days. Taurine has numerous beneficial effects on the cardiovascular system and BP. Taurine’s dose is 2 to 3 g/d at but doses around 6 g/d could be required to reduce BP.
In conclusion, amino acids, as well as proteins in this case, are ultimately essential towards improving cardiovascular disease and hypertension. As the essential building block of a majority of the human body’s biological processes, amino acids, as well as the proper consumption of protein, can help maintain a balanced metabolism in order to continue improving cardiovascular disease and hypertension. The scope of our information is limited to chiropractic and spinal injuries and conditions. To discuss the subject matter, please feel free to ask Dr. Jimenez or contact us at 915-850-0900 .
By Dr. Alex Jimenez
Additional Topics: Wellness
Overall health and wellness are essential towards maintaining the proper mental and physical balance in the body. From eating a balanced nutrition as well as exercising and participating in physical activities, to sleeping a healthy amount of time on a regular basis, following the best health and wellness tips can ultimately help maintain overall well-being. Eating plenty of fruits and vegetables can go a long way towards helping people become healthy.
Protein is an essential part of a balanced nutrition. The human�body utilizes protein to build and repair tissues. Protein is also used to make enzymes, hormones, and other fundamental body chemicals. Protein is an important building block of bones, muscles, cartilage, skin, and blood. However, for many individuals, the source of these proteins can often also be full of saturated fats, and too much of it can increase the risk of cardiovascular disease.
Can protein cause cardiovascular disease and hypertension?
Protein can be found in�chicken, pork, fish, beef, tofu, beans, lentils, yogurt, milk, cheese, seeds, nuts, and eggs. The issue with consuming some of these sources of protein that are rich in saturated fats as well is that such can increase the levels of low-density lipoprotein cholesterol (LDL), or in other words, the “bad” cholesterol. Increased levels of LDL cholesterol have been associated with cardiovascular disease and even hypertension. Research studies focusing on the connection between protein intake and CVD as well as hypertension have been conducted to reveal this correlation.
Protein & Cardiovascular Disease
Observational and epidemiologic studies have demonstrated a decrease in blood pressure, or BP, and a consistent association between a high protein consumption and incident BP. The protein source is an important element when it comes to the effect of blood pressure in the body; where animal protein has become less effective than non-animal or plant protein, especially that in almonds. At the Inter-Salt Study of over 10,000 subjects, individuals who have a dietary protein consumption of about 30 percent over the average had reduced BP by 3.0/2.5 mmHg compared to those that were 30 percent below the average. However, wild or lean animal protein with essential and less saturated fats and fatty acids may decrease CHD, lipids and BP risk.
A meta-analysis supported these findings and also indicated that hypertensive individuals and the elderly have the BP reduction with protein intake. Still another meta-analysis of 40 trials with 3277 patients found reductions in BP of 1.76/1.15 mmHg compared to carbohydrate consumption (p < 0.001). Both vegetable and animal protein significantly and equally reduced BP at 2.27/1.26 mmHg and 2.54/0.95 mmHg respectively. Dietary protein consumption is inversely related to risk for stroke. A randomized cross-over study in 352 adults with pre-hypertension and stageIhypertension found a significant decrease in SBP of 2.0 mmHg with soy protein and 2.3 mmHg with milk protein compared to a high glycemic index diet over each of the 8 wk treatment periods. A non-significant decrease has been in DBP. Another RDB parallel study over 4 weeks of 94 subjects with prehypertension and stageIhypertension found significant reductions on office BP of 4.9/2.7 mmHg in those given a combo of 25 percent protein intake vs the control group awarded 15 percent protein within an isocaloric manner. The protein consisted of pea , 20 percent soy, egg that is 30 percent and isolate. The daily recommended intake of nourishment from many sources is 1.0 to 1.5 g/kg body weight, varying with exercise level, age, renal function and other factors.
Fermented milk supplemented with whey protein concentrate reduces BP in. Administration of 20 g/d of hydrolyzed whey protein nutritional supplement rich in bioactive peptides significantly decreased BP more than 6 weeks from 8.0 � 3.2 mmHg in SBP and 5.5 � 2.1 millimeters in diastolic BP. Milk peptides, which equal caseins and whey proteins, are a rich source of ACEI peptides. Val-Pro-Pro and Ile-Pro-Pro awarded at 5 to 60 mg/d have varying reductions in BP using an average reduction in pooled studies of approximately 1.28-4.8/0.59-2.2 mmHg. Yet recent meta-analysis did not reveal significant reductions in BP in people. Powdered fermented milk using Lactobacillus helveticus given at 12 g/d significantly lowered BP from 11.2/6.5 mmHg in 4 weeks. A dose response study revealed reductions in BP. The response is attributed to fermented milk peptides which inhibit ACE.
Pins et al administered 20 g of whey protein that is hydrolyzed and noticed that a BP reduction of 11/7 mmHg compared to controls. Whey protein is successful in enhancing arterial stiffness, insulin resistance, glucose, lipids and BP. These data indicate that the protein must be hydrolyzed so as to exhibit an antihypertensive effect, and also the maximum BP reaction is dose dependent. Bovine peptides and whey peptides that are protein-derived exhibit ACEI activity. These components comprise B-caseins, B-lg B2-microglobulin, fractions and serum albumin. ACEI peptides are released by the hydrolysis of whey protein isolates. Marine collagen peptides (MCPs) from deep sea fish have anti-hypertensive activity. A double-blind placebo controlled trial in 100 hypertensive subjects with diabetes who received MCPs twice a day for 3 months had significant reductions in DBP and mean. Bonito protein (Sarda Orientalis), from the tuna and mackerel family has natural ACEI inhibitory peptides and reduces BP 10.2/7 mmHg in 1.5 g/d.
Sardine muscle protein, which contains Valyl-Tyrosine (VAL-TYR), significantly lowers BP in hypertensive subjects. Kawasaki et al treated 29 hypertensive subjects with 3 milligrams of VAL-TYR sardine muscle focused extract for four wk and reduced BP 9.7/5.3 mmHg (p < 0.05). Levels of aldosterone and A-Iincreased as serum A-II diminished suggesting that VAL-TYR is a ACEI. BP was considerably lowered in a study using a vegetable drink with protein hydrolysates in 13 weeks.
Soy protein reduces BP in patients in most studies. Soy protein consumption was inversely and significantly correlated with both DBP and SBP in 45694 Chinese girls or more of soy protein within 3 years and the association increased with age. The SBP decrease was 1.9 to 4.9 mm reduced and the DBP 0.9 to 2.2 mmHg lower. However, meta-analysis and trials have shown mixed results on BP to reductions of 7 percent to 10 percent for SBP and DBP with no change in BP. The current meta-analysis of 27 trials found a substantial reduction in BP of 2.21/1.44 mmHg. Some studies suggest improvement in ACEI activity, reduction in inflammation and HS-CRP, cognitive function arterial compliance, decrease in tone activity and reduction in both oxidative stress and levels. Fermented soy at roughly 25 g/d is suggested.
Besides ACEI consequences, protein consumption may also alter responses and induce a natriuretic. Low protein intake coupled with low omega 3 fatty acid intake can lead to hypertension in animal models. The perfect protein intake, based on degree of activity, renal function, stress and other factors, is about 1.0 to 1.5 g/kg daily.
In conclusion, protein is an important part of a balanced diet, however, leaner alternatives containing less amounts of saturated fats are ideal to prevent the risk of cardiovascular disease and hypertension, promoting overall health and wellness. Many individuals consume higher amounts of proteins than necessary. A healthcare professional specializing in diet and nutrition can help you come up with the best nutritional plan for your and your specific health concerns. The scope of our information is limited to chiropractic and spinal injuries and conditions. To discuss the subject matter, please feel free to ask Dr. Jimenez or contact us at 915-850-0900 .
By Dr. Alex Jimenez
Additional Topics: Wellness
Overall health and wellness are essential towards maintaining the proper mental and physical balance in the body. From eating a balanced nutrition as well as exercising and participating in physical activities, to sleeping a healthy amount of time on a regular basis, following the best health and wellness tips can ultimately help maintain overall well-being. Eating plenty of fruits and vegetables can go a long way towards helping people become healthy.
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