Back Clinic Functional Medicine Team. Functional medicine is an evolution in the practice of medicine that better addresses the healthcare needs of the 21st century. By shifting the traditional disease-centered focus of medical practice to a more patient-centered approach, functional medicine addresses the whole person, not just an isolated set of symptoms.
Practitioners spend time with their patients, listening to their histories and looking at the interactions among genetic, environmental, and lifestyle factors that can influence long-term health and complex, chronic disease. In this way, functional medicine supports the unique expression of health and vitality for each individual.
By changing the disease-centered focus of medical practice to this patient-centered approach, our physicians are able to support the healing process by viewing health and illness as part of a cycle in which all components of the human biological system interact dynamically with the environment. This process helps to seek and identify genetic, lifestyle, and environmental factors that may shift a person’s health from illness to well-being.
Lower abdominal pain relieved by passing stool or gas
Alternating constipation and diarrhea
A hard, dry, or small stool
Use laxatives frequently
If you are experiencing any of these situations, then you must be experiencing gastrointestinal impairments in your body.
Gastrointestinal Impairments
The digestive system is consisting of the gastrointestinal tract, which is home to the intestines, the liver, the colon, the gallbladder, the pancreas, and the stomach. When there is a disruption in the gastrointestinal tract, it can cause inflammation and chronic illnesses that can harm the body. Functional disorders in the digestive tract (GI tract) can look normal in the body, but it doesn’t work correctly.
Many factors can upset the GI tract and its motility, including:
Eating a diet low in fiber
Not getting enough exercise
Traveling or changes in a routine
Eating large amounts of dairy blankets
Stress
Resisting the urge to have a bowel movement
Overusing laxatives
Taking certain medicines
Some of the most common problems that can affect the GI tract are constipation, IBS, and colon cancer.
Irritable Bowel Syndrome
IBS (irritable bowel syndrome) is a long term gastrointestinal disorder. It can cause abdominal pain, bloating, mucus in the stool, irregular bowel habits, and can alternate diarrhea and constipation. IBS can cause persistent discomfort to individuals, but they can improve the symptoms over time as they learn to manage the condition.
Some of the symptoms caused by IBS are:
Changes in bowel habits
Abdominal pain and cramping that lessens after using the bathroom
A feeling that the bowels not fully emptied after using the bathroom
Excess gas
The passing of mucus from the rectum
The sudden urgent need to use the bathroom
Swelling or bloating from the abdomen.
Signs and symptoms of IBS can vary between individuals and can often resemble other diseases and conditions. IBS symptoms can often get worst after earing, and a flare-up may last about 2 to 4 days, then the symptoms may either improve or go away entirely, but IBS symptoms can affect different body parts.
These can include:
Frequent urination
Bad breath
Headaches
Joint or muscle pain
Persistent fatigue
Anxiety
Depression
Constipation
Constipation is one of the most common digestive problems that affects around 2.5 million individuals. It is a syndrome that is defined by bowel symptoms (painful or infrequent passage of stool, the hardness of stool, or a feeling of incomplete evacuation) that may occur either in isolation or secondary to another underlying disease like for example, Parkinson’s disease.
The cause of constipation is through the colon. The colon’s main job is to absorb water from leftover food as it passes through the digestive system and creates waste. When the waste is ready to be excreted out, the colon’s muscles propel the waste out through the rectum to eliminate from the body. If the debris remains in the colon for too long, though, it can be tough and challenging to excrete it out of the body.
Some factors can cause constipation; this can include:
Stress
Low-fiber diet
Lack of exercise
Certain medications
Particular diseases like a stroke, Parkinson’s disease, and diabetes
Problems with the colon or rectum
Hormonal issues
Everyone’s definition of a regular bowel movement may be different. Some people can go about three times a day, while others can go to relieve themselves about three times a week. Some of the symptoms of constipation included are:
Fewer than three bowel movements a week
Passing hard, dry stools
Straining or pain during bowel movements
Still feeling full after a bowel movement
Experiencing a rectal blockage
Colon Cancer
Colon cancer is the third most common type of cancer. When tumorous growths develop in the large intestine or the colon, it develops colon cancer in the GI tract. The colon, the one organ where the body draws out water and salt from solid wastes. The waste then moves through the rectum and excretes out of the body through the anus.
Even though colon cancer doesn’t cause any symptoms in the earliest stages, but it can become more noticeable as the disease progresses. Some of the sign and symptoms of colon cancer include:
Diarrhea or constipation
Changes in stool consistency
Loose, narrow stools
Blood in the stool
Abdominal pain
Weakness and fatigue
Iron deficiency
If colon cancer spreads to a new location the gastrointestinal system, it can cause additional problems in the new area.
Conclusion
Having gastrointestinal impairments can cause the body to develop chronic illnesses. There are ways to make sure that the digestive tract is functioning correctly. An individual can change their diets and lifestyle and can make sure that their gut is working properly. When there is a disruption in the GI tract like IBS, constipation, and colon cancer, it can lead to many health problems if the individual is not careful. If an individual prolongs the symptoms, then they will develop life-long issues for their body. Some products help support the intestinal tract and help strengthens the natural defenses and support the intestinal immune function.
October is Chiropractic Health Month. To learn more about it, check out Governor Abbott�s declaration on our website to get full details on this historic moment.
The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or chronic disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .
References:
Bharucha, Adil E, et al. �American Gastroenterological Association Technical Review on Constipation.� Gastroenterology, U.S. National Library of Medicine, Jan. 2013, www.ncbi.nlm.nih.gov/pmc/articles/PMC3531555/.
Brazier, Yvette. �Irritable Bowel Syndrome (IBS): Symptoms, Diet, Causes, and Treatment.� Medical News Today, MediLexicon International, 18 Dec. 2017, www.medicalnewstoday.com/articles/37063.php.
Crosta, Peter. �Colon Cancer: Symptoms, Treatment, and Causes.� Medical News Today, MediLexicon International, 28 Aug. 2019, www.medicalnewstoday.com/articles/150496.php.
Sethi, Saurabh. �What You Should Know About Constipation.� Healthline, 23 Aug. 2019, www.healthline.com/health/constipation.
Whitfield, K Lynette, and Robert J Shulman. �Treatment Options for Functional Gastrointestinal Disorders: from Empiric to Complementary Approaches.� Pediatric Annals, U.S. National Library of Medicine, May 2009, www.ncbi.nlm.nih.gov/pmc/articles/PMC2830707/.
The percentage of individuals that are affected by fatigue, headaches, and overall pain is continuously growing. For the most part, these symptoms can all be linked back to a hormone imbalance. Hormone imbalances are more common than individuals realize and can affect people of all ages. Originally, hormone testing was completed through a blood draw (serum testing). However, as science is improving, there are now better, more functional ways of testing.��
As more and more studies are done, it is becoming more clear that salivary testing is superior to serum (blood) testing for hormones. There are two forms in which hormones exist in the human body, free (5%) and protein-bound (95%). Due to the protein-bound hormones being bound, they become too large to pass through into the salivary glands. This meaning that they are not bio-available and can not be delivered to the receptors in the tissues of the body.� The unbound hormones, or free hormones, are the relevant hormones that are found in the saliva. Considering the fact that free hormones are not as abundant, the hormone levels found in saliva are significantly less than those found in serum. However, many patients who are treated with serum hormone results are often overdosed because of the lack of correlation between bio-availability.
Labrix by Doctor’s Data
Similar to the D.U.T.C.H�hormone testing previously discussed, this company Labrix offers a variety of hormone testing as well.
Neurotransmitters:
NeuroBasic: ideal for monitoring therapeutic interventions of neurotransmitter imbalances previously tested or when symptoms are indicating an imbalance. This test measures Serotonin, Dopamine, Epinephrine, Norepinephrine, Glutamate, Glycine, Histamine, and Phenethylamine
Comprehensive Neurotransmitter: best when a comprehensive look at neurotransmitter secretion and metabolism of markers is needed. This test measures Serotonin, GABA, Dopamine, Norepinephrine, Epinephrine, Glutamate, Glycine, Histamine, and Phenethylamineand DOPAC, 3-MT, Normetanephrine, Metanephrine, 5-HIAA, Tryptamine, Tyrosine, Tyramine, and Taurine.
NeuroHormones:�
NeuroHormone Complete Plus:� provides insight on how the HPA axis function may be contributing to patients’ symptoms, such as mood swings, fatigue, and pain. In addition, this test is ideal for those who are at risk for breast cancer, PCOS, or a strong family history of autoimmune disease.�This test is recommended for women only.� This test measures�Estrone, Estradiol, Estriol, Progesterone, Testosterone, DHEA, Cortisol x 4, Serotonin, GABA, Dopamine, Epinephrine, Norepinephrine, Glutamate, Glycine, Histamine, Phenethylamine
NeuroHormone Complete: useful for patients (men or women) who are experiencing any type of mood disorder, addiction, fatigue, chronic illness, confusion, weight issues, low libido, PMS, or chronic pain. This test measures Estradiol, Progesterone, Testosterone, DHEA, Cortisol x 4, Serotonin, GABA, Dopamine, Epinephrine, Norepinephrine, Glutamate, Glycine, Histamine, Phenethylamine.�
NeuroAdrenal: Included in this test is a full diurnal cortisol pattern, DHEA, and 6 primary neurotransmitters to help those with symptoms such as depression, anxiety, addiction, chronic illness, and low libido. This test measures DHEA, Cortisol x 4, Serotonin, GABA, Dopamine, Epinephrine, Norepinephrine, Glutamate, Glycine, Histamine, Phenethylamine
Salivary Hormone:�
Comprehensive Plus: provides an assessment of breast cancer risk. This test is a considerationfor women only who have an increased risk for developing breast cancer, other hormonally sensitive cancers, PCOS or a family history of autoimmune disease. This test measures estrone, estriol, and Estrogen Quotient.
Women’s Helth and breast Profile: includes two risk assessment ratios, the Estrogen Quotient and the Pg/E2 ratio
Comprehensive Hormone: �assessment of hormonal status and endocrine function and includes estradiol, progesterone, testosterone, DHEA and four cortisols. This profile is useful with male and female patients because it looks at the full diurnal cortisol pattern; it is especially important in patients who are experiencing the full diurnal pattern ( weight gain, high blood sugar, elevated lipids, chronic fatigue)
Short Comprehensive: useful in men and women whose primary symptoms are related to sex hormone imbalances (elevated or depressed E2, P or T)
Basic Hormone: a basic evaluation of the sex hormones and a brief glimpse at the adrenal function with the AM cortisol level. Best for men who are experiencing decreased libido, erectile dysfunction, loss os stamina, decreased mental sharpness and metabolic syndrome. Best for women who are experiencing hot flashes, anxiety, night sweats, breast tenderness, irritability, forgetfulness, and acne.�
Comprehensive Adrenal Function: provides insight into the body�s stress response. This test measures sIgA
Adrenal Function: comprehensive view of adrenal function, DHEA, and cortisol levels. This is best for people who are fatigued, nervous, weak, crave sugar, have headaches, irritability, and depression
Diurnal Cortisol: Similar to the test above but for patients who do not need DHEA testing
Melatonin: Provides a snapshot of the sleep/wake cycle during a one day period
Salivary Hormone + CAR :
CAR: has the capability to test all the same markers as above but adds Cortisol Awakening Response “CAR” to all of them.�
For more information regarding testing and hormones tested, please visitlabrix.com��
LABRIX BASIC BOX CONTENTS:
Upon opening every box (no matter the labrix test) the patient will see a requisition form, a billable stamp, and a FedEx envelope. Under these two items, a styrofoam box (insulated cooler) with the imprint “doctorsdata.com” will be present. Once the patient lifts the lid off of the styrofoam box, they will see two more pieces of paper.� The first being a list of symptoms (patient survey) on a white sheet of paper that the patient is to fill out and place back in the styrofoam box and the second a small instruction manual.
Neurotransmitter Tests Breakdown
For the Neurotransmitter Tests, the patient is provided with the basic kit described above. The only sample type required for the neurotransmitter tests is urine.
The contents of the styrofoam box include a small plastic cup, a clear plastic bag consisting of a white tube, a dropper, an absorbent pad, and a Lab-Brix ice pack. The first step is to freeze the ice-pack and keep it frozen until ready to ship.�
In order for this test to have proper results, the patient should collect their sample with their first or second-morning urine upon waking. Then, select on the requisition form which urine ( first or second ) the sample was collected from. It is also important to note on the requisition form what time the patient woke and what time the sample was collected. The urine sample should be collected midstream. Patients will collect their sample in the plastic cup provided, not directly in the tube. Next, the patients will use the dropper provided to transfer 10 ml of the sample from the cup into the tube. Ensure the lid is screwed on tightly and gently rock the tube back and forth for 3-5 seconds to mix the urine with the preservative. The patients will then wrap the absorbent pad around the tube (not inside the tube), and place the sample tube back in the plastic bag. The bag is then to be placed in the freezer for 4-6 hours, and is to be kept frozen until ready to ship!�
Neurotransmitter + Hormone Tests Breakdown
The Neurotransmitter + Hormone analysis tests consist of urine and saliva samples. This basic test kit includes everything above. However, upon opening this styrofoam box the patient will find two plastic bags. The first being a plain plastic clear bag with a dropper, white test tube, and absorbent pad. The second plastic bag is a biohazard bag that has multiple colors on the outside and consists of 4 clear small straws, an absorbent pad, and 4 small saliva collection tubes of various colors.�
The urine sample is instructed to be taken the same way as the neurotransmitter test.
The patient should collect their sample with their first or second-morning urine upon waking. Then, select on the requisition form which urine ( first or second ) the sample was collected from. (Remember, the individual is� to note on the requisition form time they woke and what time the sample was collected). Patients will collect their sample mid-stream in the plastic cup provided, not directly in the tube. Next, use the dropper provided to transfer 10 ml of the sample from the cup into the tube. Be sure to check that the lid is screwed on tightly and gently rock the tube back and forth for 3-5 seconds to mix the urine with the preservative. The patients will then wrap the absorbent pad around the tube (not inside the tube), and place the sample tube back in the plastic bag. The bag is then to be placed in the freezer for 4-6 hours, and is to be kept frozen until ready to ship!��
The salivary collection has a few more steps considering it is 4 samples rather than one. The timing for the salivary testing is critical, so timers are encouraged. As the patient wakes up, a timer should be set for 30 minutes later. This is when the first salivary sample (the pink tube) is to be collected. Before this test, the patient should not eat, drink, brush or floss. The second collection (green tube) is to be taken right before lunch, around noon. The third (orange tube), is to be collected in the evening before dinner, and the final collection (blue tube) before bed at night.�
For all salivary collections, each tube needs to be 3/4 of the way full. The straws provided are the patient’s choice to be used. As soon as the tube is 3/4 of the way full, snap the saliva lid tightly, put into the bag in which it came, and freeze for 4-6 hours, until ready to ship. Patients are to record the date and times of the saliva collections on the bag and requisition form.�
Salivary Hormone
Considering the salivary hormone testing is done using 4 saliva samples, the instructions are the same as the saliva collection in the test mentioned above. However, to review them again,�the timing for the salivary testing is critical, so timers are highly encouraged.
As the patient wakes up, a timer should be set for 30 minutes later. This is when the first salivary sample (the pink tube) is to be collected. Before this test, the patient is not to eat, drink, brush or floss. For the second collection (green tube), it should be collected right before lunch, around noon. The third (orange tube), is to be obtained in the evening before dinner, and the final sample (blue tube) before bed at night.�
For all salivary collections, each tube needs to be 3/4 of the way full. The straws provided are to be used at the patient’s discretion. As soon as the tube is 3/4 of the way full, snap the saliva lid tightly, put into the bag in which it came, and freeze for 4-6 hours, until ready to ship. Patients are to record the date and times of the saliva collections on the bag and requisition form.�
Salivary Hormone + CAR Breakdown
Aside from the basic components, the styrofoam box includes 6 colored salvia collection tubes, 6 straws, and an absorbent pad. The tests that fall under this category require 6 samples throughout the day. It is important to remember to write down the time the samples were collected as well as the time when the patient first woke up. The first sample (yellow tube) is to be taken as soon as the patient is awake but has not gotten out of bed. In order to accomplish this properly, it is best the patient sets the tube next to their bed the night before. This makes it easy to collect first thing in the morning. It is very important that the patient sets an alarm for 30 minutes after they wake up ( second test, pink tube)and for 1 hour after they wake up (third test, lavender tube). These tests are all to be done prior to eating breakfast, brushing and flossing teeth. The fourth collection (green tube) is to be taken before lunch and the fifth (orange tube) before dinner. The sixth and final sample (blue tube) is to be collected at least one hour after dinner. Just as the other saliva samples mentioned above, these tubes are to be filled 3/4 of the way, tightly closed, placed back in the bag they came in and frozen for 4-6 hours, or until they are ready to ship.
SHIPPING INSTRUCTIONS FOR ALL TESTS:
Shipping should be done Monday-Friday as this will ensure the sample will be delivered to the lab on time. Make sure all paperwork is filled out properly and place contents back in the styrofoam box in the following order:�
sealed plastic bag with frozen specimen tubes
frozen ice pack�
requisition form, symptom sheet, and payment (if applicable)�
Next, place the lid back on the box and place the entire styrofoam box in the cardboard collection kit. Close the cardboard box and place it inside the FedEx shipping envelope provided. The patient will then write their name and address on the Billable Stamp and tear off the customer receipt for their records. Then, place on the FedEx envelope. The final step is to schedule a pick-up. In order to do this, the patient will call the FedEx toll-Free number at 1-800-463-3339 and select “schedule a pickup”. This MUST be a scheduled pick up from an address and NOT a dropbox.�
* It is important to note that patients should avoid eating avocados, eggplant, tomatoes, bananas, melons, pineapples, plums, nuts, nut butter, wine, cheese and chocolate 48 hours before and during the testing period as these could impact the results.
* Patients should keep in mind that strenuous exercise, alcohol, coffee, tea, tobacco or any other product containing nicotine is to be avoided 24 hours before and during the collection period.
Labrix is a great company that allows patients a noninvasive way to have their hormone levels checked. Almost every patient who walks in the door can benefit from this test. I highly recommend this test because hormone levels can change based on age, PMS symptoms, fatigue, blood sugar issues, or stress! These results are accurate and have a decently quick turn around time. Gaining insight and taking control of your body is now easier than ever. – Kenna Vaughn, Senior Health Coach
The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or chronic disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.
*All information and photos/video content for this article are directly sourced from labrix. Please see labrix for more information and credit.
Do you feel that you must have sweets after meals? Do you get light-headed if you miss a meal? Or feel that craving for sweets during the day? Does your body feels shaky jittery or have tremors? If you are experiencing any of these situations, you may be experiencing LADA.
LADA
Autoimmune diabetes is a heterogeneous disease that can arise at any age. Anyone with adult-onset autoimmune diabetes who does not necessitate insulin therapy for at least six months after being diagnosed may have LADA (latent autoimmune diabetes of adulthood). LADA is a slowly progressing form of autoimmune diabetes, and it has been estimated that 20% of people are diagnosed with having non-obesity-related type 2 diabetes.
LADA occurs when the pancreas stops producing adequate insulin and slowly damages the insulin-producing cells in the pancreas, harming the body�s function. It is clear, however, that the frequency of autoimmune diabetes among adults can be underestimated, and clinical features such as age and severity of symptoms are of no help in identifying patients that have LADA since there is still more research being done to treat LADA. The body mass index and C peptide levels in the general population can increase with age, and these parameters are of limited use in identifying LADA patients.
Different Types of Diabetes
In a person, diabetes is a condition that impairs the body’s ability to process blood glucose, and roughly the estimated number of people over 18 years of age that are diagnosed and undiagnosed with diabetes is about 30.2 million. Without ongoing, careful management, diabetes can lead to a build-up of sugars in the blood, which can increase the risk of dangerous complications, including stroke and heart disease.
There are different kinds of diabetes, including LADA, that can occur, and managing the condition depends on the type of diabetes an individual has.
Type 1 Diabetes
Type 1 diabetes is also known as juvenile diabetes, and the body does not produce enough insulin, and the blood glucose level remains high in the body. People with type 1 diabetes are insulin-dependent and must take artificial insulin daily to stay alive. The immune system attacks a cluster of cells known as islets in the pancreas that would typically produce insulin and stopping or slowing down the insulin production in the body.
When a person receives a diagnosis of type 1 diabetes from healthcare professionals, the islet cells are responsible for insulin secretion from the pancreas may continue to produce the insulin hormone for a while before ceasing. It can also lead to the production of LADA if it is not being monitored.
The physical effects of type 1 diabetes include:
Increased hunger and thirst
Frequent urination
Blurry vision
Tiredness and fatigue
Weight loss without an apparent trigger or causes.
Type 2 Diabetes
Type 2 diabetes is one of the most common forms of diabetes and can appear at any age, affecting over 30 million Americans. It happens when the blood sugar levels rise due to problems with the use or production of insulin.
Studies show that most people do not experience the symptoms in the early stages of type 2 diabetes, and they might have symptoms for many years. For those that do have type 2, diabetes may have acanthosis nigricans. Acanthosis nigricans is a skin condition that causes the skin to become thicker and darker. It often appears mostly on the neck, elbows, knees, knuckles, the folds around the neck and the groin.
Other early symptoms of type 2 diabetes that an individual may have included:
Frequent bladder, kidneys, or skin infections
Cuts that take longer to heal
Fatigue
Extreme hunger
Increased thirst
Urinary frequency
Blurred vision
Mixed Diabetes (Type 1.5)
Mixed diabetes or LADA is an autoimmune condition that shares the characteristics of both type 1 and type 2 diabetes in adults. It is diagnosed during adulthood and sets in the bloodstream gradually; however, unlike type 2, LADA is an autoimmune disease and is not reversible if the person changes their diet and lifestyle. �It can be triggered by the damage done to the pancreas from the antibodies against the insulin-producing cells.
If a person has LADA, their beta cells stop functioning much more quickly than type 2 diabetes. Researchers have found out that an estimated 10 percent of people who have diabetes will have LADA. It stated that the treatment for LADA patients is far less elucidated than the cases for type 1 and type 2 diabetes. Finding a treatment strategy for LADA can reduce the decline of beta-cell function, ensures adequate metabolic treatment so far.
Some of the symptoms that LADA patients may have include:
Frequent thirst
Increased urination, including at night
Unexplained weight loss
Blurred vision
Tingling nerves
If LADA is left untreated, it can lead to diabetic ketoacidosis, which is a condition where the body can not utilize sugar as fuel due to the absence of insulin and starts burning fat. It produces ketones, which are toxic to the body.
Type 3 Diabetes
Type 3 diabetes is known as brain diabetes and has an established linked to Alzheimer’s disease. This type of diabetes is triggered by a type of insulin resistance and an insulin-like growth factor dysfunction that occurs specifically in the brain, causing dementia.
Alzheimer�s disease has characteristics histopathological, molecular, and biochemical abnormalities in the brain’s cell structure. Since it has been linked with type 3 diabetes, characteristic features of type 3 diabetes include impairments in insulin actions and signaling that result in chronic hyperglycemia, irrespective of subtype, etiology, pathogenesis, or insulin availability.
Conclusion
Autoimmune diabetes can affect anyone at any age. It can damage the pancreas walls to stop producing insulin to the body, causing problems for an individual. LADA (latent autoimmune diabetes in adults) is an autoimmune disease that has the characteristics of type 1 and type 2 diabetes that are in adults. There is still more research being done to treat LADA, and there are products that can help support sugar metabolism and maintain blood sugar levels to a healthy range.
October is Chiropractic Health Month. To learn more about it, check out Governor Abbott�s declaration on our website to get full details on this historic moment.
The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or chronic disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .
References:
Barhum, Lana. �Type 2 Diabetes: Symptoms, Early Signs, and Complications.� Medical News Today, MediLexicon International, 16 Apr. 2019, www.medicalnewstoday.com/articles/317462.php.
Castro, M. Regina. �Latent Autoimmune Diabetes in Adults (LADA): What Is It?� Mayo Clinic, Mayo Foundation for Medical Education and Research, 10 May 2019, www.mayoclinic.org/diseases-conditions/type-1-diabetes/expert-answers/lada-diabetes/faq-20057880.
de la Monte, Suzanne M, and Jack R Wands. �Alzheimer’s Disease Is Type 3 Diabetes-Evidence Reviewed.� Journal of Diabetes Science and Technology, Diabetes Technology Society, Nov. 2008, www.ncbi.nlm.nih.gov/pmc/articles/PMC2769828/.
Felman, Adam. �Type 1 Diabetes: Overview, Symptoms, and Treatment.� Medical News Today, MediLexicon International, 19 Nov. 2018, www.medicalnewstoday.com/articles/323729.php.
Hals, Ingrid K. �Treatment of Latent Autoimmune Diabetes in Adults: What Is Best?� Current Diabetes Reviews, U.S. National Library of Medicine, 2019, www.ncbi.nlm.nih.gov/pubmed/30009709.
Leonard, Jayne. �Acanthosis Nigricans: Causes, Symptoms, Treatment, and Pictures.� Medical News Today, MediLexicon International, 21 Dec. 2018, www.medicalnewstoday.com/articles/324062.php.
MSN, Rachel Nall RN. �Diabetes: Symptoms, Treatment, and Early Diagnosis.� Medical News Today, MediLexicon International, 8 Nov. 2018, www.medicalnewstoday.com/articles/323627.php.
Pozzilli, Paolo, and Silvia Pieralice. �Latent Autoimmune Diabetes in Adults: Current Status and New Horizons.� Endocrinology and Metabolism (Seoul, Korea), Korean Endocrine Society, June 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6021307/.
Prelipcean, Maria S. �What You Need to Know About Type 1.5 Diabetes.� Healthline, 2 Nov. 2018, www.healthline.com/health/type-1-5-diabetes.
Watson, Kathryn. �Type 3 Diabetes and Alzheimer’s Disease: What You Need to Know.� Healthline, 16 Oct. 2019, www.healthline.com/health/type-3-diabetes.
Wint, Carmella, and Marijane Leonard. �What You Should Know About Diabetic Ketoacid.� Healthline, 4 Dec. 2018, www.healthline.com/health/type-2-diabetes/ketoacidosis.
Microbes have multicellular hosts and can have many effects on the host�s health and well-being. Researchers have stated that microbes influence metabolism, immunity, and behavior on the human body. One of the most important but understudied mechanisms that microbes have is that they can involve hormones. In the presence of gut microbiota, specific changes in hormone levels can correlate in the gut. The gut microbiota can produce and secrete hormones, respond to the host hormones, and regulate their expression levels. There is also a link between the endocrine system and the gut microbiota as more information is still being researched.
The Gut to Hormone Connection
Since the human microbiome contains a vast array of microbes and genes that shows a higher complexity. Unlike other organs in the body, the gut microbiota’s function is not fully understood yet but can be disrupted easily by antibiotics, diet, or surgery. The best-characterized function is how the gut microbiota interacts with the endocrine system in the body.
Emerging research has indicated that the gut microbiome plays a central role in regulating estrogen levels within the body. When the estrogen hormone levels are too high or too low, it can lead to the risk of developing estrogen-related diseases like endometriosis, polycystic ovary syndrome, breast cancer, and prostate cancer to males and females.
The gut to hormone connection is essential since the gut is one of the producers to create hormones that travel through the entire body system. With the endocrine system is being involved, it is the first network to produce and transport hormones to the organs that need the hormones to function. When there is an imbalance of hormones in the human body, it can disrupt all the other hormones.
The gut microbiota influences nearly every hormone that the endocrine system creates, including:
The thyroid hormones
Estrogen hormones
Stress hormones
Thyroid Hormones
If the gut has inflammation, then the hormones in the body will create an excessive or low quantity in the body. If the endocrine glands like thyroid, are producing a low quantity of hormones and the gut can be imbalanced and lead to hypothyroidism. When there is low microbial diversity in the gut, studies have shown that the low microbial diversity is linked to high TSH (thyroid-stimulating hormone) levels. The excessive quantity of thyroid hormones can lead to hyperthyroidism. Both hyperthyroidism and hypothyroidism can cause symptoms like irritability, anxiety, poor memory, and many symptoms that can affect the body.
“If you are experiencing excessive belching, burping, bloating, difficult bowel movements difficulty digesting proteins and meats; undigested food found in stools, digestive problems subside with rest and relaxation or any symptoms. Then this article will give you a better understand what is happening with the gut and how hormones can affect the gut system.”
Estrogen Hormones
The gut and an individual’s hormones are meant to be in communication with each other. They not only support each other, but they also work together to make sure the body is running smoothly. Studies have found out that the gut’s intestinal cells have special receptors for hormones that allow them to detect any hormonal shifts that affect the body.
Since estrogen is typically associated with women, it is common that men need the right amount of estrogen levels to function. The gut microbiota is the key regulator of leveling and circulating estrogen in the body. The microbes produce an enzyme called beta-glucuronidase, which then converts the estrogen hormone to its active form.
The gut microbiome can regulate estrogen levels by functioning a specific bacteria in the microbiome called estrobolome. Estrobolome is the aggregates of enteric bacterial genes that are capable of metabolizing estrogen. It might affect women’s risk of developing postmenopausal estrogen receptor-positive breast cancer. The estrobolome is highly essential to keep estrogen levels in the body at a stable state.
In the gut microbiota, both the estrogen and progesterone hormones can impact the guts’ motility and peristalsis ( The rhythmic movement of the intestines that move food through the stomach and out of the body) by playing opposing roles in the guts� motility. Progesterone helps slow down the gut�s motility by relaxing the smooth and slowing transit the time the food is moving out of the body. Estrogen helps increase the contraction of the smooth muscles in the intestines. When the estrogen hormones are leveled right, it can help keep the gut moving smoothly and help increase the diversity of the body�s microbiomes, which is a good thing for the immune system.
Stress Hormones
Stress hormones or cortisol plays a massive part in the gut microbiota. Since cortisol hormones connect to the brain, it sends the signals to the gut and vice versa. If it is a short stressor like getting ready for a presentation or a job interview, the person will feel “butterflies” in their gut. The longer stressors, for example, like having a highly stressful job or feeling anxious consistently, can lead to chronic illnesses in the gut like inflammation or leaky gut. Since the hormone and gut connection is in sync with the gut and brain connection, it is crucial to lowering the cortisol levels to a stable state for a healthy functional body.
Conclusion
The gut and hormone connections are profoundly meaningful since they are linked closely together. When there is a disruption on the gut, it can cause hormones to be imbalanced, causing many disruptions like inflammation and leaky gut. When there is a disruption in the hormones, it can disrupt the gut as well by negatively shifting the gut’s microbiome. So to ensure that the gut is functioning correctly, it is crucial to eat food that contains probiotics and is fermented to keep the gut flora healthy. Some products can help counter the metabolic effects of temporary stress and supporting estrogen metabolism by incorporating other essential nutrients and cofactors to support the endocrine system.
October is Chiropractic Health Month. To learn more about it, check out Governor Abbott�s declaration on our website to get full details on this historic moment.
The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or chronic disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .
References:
Author, Guest. �How Your Gut Microbiome Influences Your Hormones.� Bulletproof, 21 Aug. 2019, www.bulletproof.com/gut-health/gut-microbiome-hormones/.
Evans, James M, et al. �The Gut Microbiome: the Role of a Virtual Organ in the Endocrinology of the Host.� The Journal of Endocrinology, U.S. National Library of Medicine, 28 Aug. 2013, www.ncbi.nlm.nih.gov/pubmed/23833275.
Kresser, Chris. �The Gut�Hormone Connection: How Gut Microbes Influence Estrogen Levels.� Kresser Institute, Kresserinstitute.com, 10 Oct. 2019, kresserinstitute.com/gut-hormone-connection-gut-microbes-influence-estrogen-levels/.
Kwa, Maryann, et al. �The Intestinal Microbiome and Estrogen Receptor-Positive Female Breast Cancer.� Journal of the National Cancer Institute, Oxford University Press, 22 Apr. 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC5017946/.
Neuman, Hadar, et al. �Microbial Endocrinology: the Interplay between the Microbiota and the Endocrine System.� OUP Academic, Oxford University Press, 20 Feb. 2015, academic.oup.com/femsre/article/39/4/509/2467625.
Szkudlinski, Mariusz W, et al. �Thyroid-Stimulating Hormone and Thyroid-Stimulating Hormone Receptor Structure-Function Relationships.� Physiological Reviews, U.S. National Library of Medicine, Apr. 2002, www.ncbi.nlm.nih.gov/pubmed/11917095.
Wieselman, Brie. �Why Your Gut Health and Microbiome Make-or-Break Your Hormone Balance.� Brie Wieselman, 28 Sept. 2018, briewieselman.com/why-your-gut-health-and-microbiome-make-or-break-your-hormone-balance/.
Endocrine disruptors are chemicals that may interfere with the body’s endocrine system and produce adverse developmental, reproductive, neurological, and immune effects in humans. It can be pesticides, plasticizers, antimicrobials, and flame retardants that can be EDCs. EDCs (endocrine-disrupting chemicals) can disrupt the hormonal balance and can result in developmental and reproductive abnormalities in the body.
There are four points about endocrine disruption:
Low dose matters
Wide range of health benefits
Persistence of biological effects
Ubiquitous exposure
EDC can cause significant risks to humans by targeting different organs and systems in the body. The interactions and the mechanisms of toxicity created by EDC and environmental factors can be concerning a person’s general health problems. Including endocrine disturbances in the body since many factors can cause endocrine disruptors, one of the disruptors in the food contaminated with PBDEs (polybrominated diphenyl esters) in fish meat and dairy.
Researchers also pointed out that once the contaminated foods eliminated from a person’s diet, then the endocrine disruptors decline, and the body began to heal properly. When a person eliminates the food that is causing discomfort to their bodies, they are more aware of reading the food labels to prevent discomfort anymore to the body systems.
Obesogen
Obesogen is a subclass of endocrine-disrupting chemicals (EDC) that might predispose individuals to the development of obesity. Their structure is mainly lipophilic, and they can increase fat deposition. Since the fat cell’s primary role is to store and release energy, researchers have found that different obesogenic compounds may have different mechanisms of action.
Some of these actions can affect the number of fat cells that are producing, while others affect the size of the fat cells, and some obesogenic compounds can affect the hormones. These compounds will affect the appetite, satiety, food preferences, and energy metabolism when the endocrine system plays a fundamental role in the body to regulate the metabolism of fats, carbohydrates, and proteins. Any alternations in the body can result in an imbalance in the metabolism and causing endocrine disorders.
Studies even stated that exposure to obesogens could be found either before birth on utero or in the neonatal period. Obesogens can even cause a decrease in male fertility. When this disruption happens to the male body, environmental compounds can cause a predispose to weight gain, and obesogens can appoint as one of the contributors because of their actions as endocrine disruptors. Obesogens can even change the functioning of the male reproductive axis and testicular physiology. The metabolism in the male human body can be pivotal for spermatogenesis due to these changes.
Endocrine Disruptors and Obesity
Some endocrine disruptors that can affect the body can be through pharmaceutical drugs that can cause weight gain. A variety of prescription drugs can have an adverse effect that can result in weight gain since the chemicals found in prescription drugs have similar structures, and modes of action might have a role in obesity. Prescription medicine can stimulate the gut to consume more food, thus involving the body to gain weight.
Another endocrine disruptor is PAHs (polycyclic aromatic hydrocarbons). These are a family of environmental chemicals that occur in oil, coal, and tar deposits. They produce as by-products of fuel-burning like fossil fuel, biomass, cigarette smoke, and diesel exhaust. PAHs can either be manufactured to be used as medicines and pesticides or be released naturally from forest fires and volcanoes.
There are standard ways a person can be exposed to PAHs. One is through eating grilled, charred, or charcoal-broiled meats that a person eats. The other is through inhalation of smoke from cigarettes, vehicle exhaust, or emissions from fossil fuels that can irritate the eyes and breathing passageways in the body.
Coping with EDC Exposure
Even though obesity can adversely affect the body in a variety of health outcomes, there are ways to cope and minimize the exposure of EDC. Research shows that a person can minimize EDC exposure by consuming organic fruits, vegetables, and grain products insofar as possible. This includes an increasing number of fungicides routinely applied to fruits and vegetables that are being identified as obesogens and metabolic disruptors in the body.
Xenoestrogen vs. Phytoestrogen
When a person has an endocrine disorder, it might be due to the food they are consuming. Phytoestrogens are plant-derived compounds that are in a wide variety of food, mostly in soy. They are presented in numerous dietary supplements and widely marketed as a natural alternative to estrogen replacement therapy.
There is a health impact on phytoestrogen, and the plant-derived compound can either mimic, modulate, or disrupt the actions of endogenous estrogen. Xenoestrogen�are synthetically derived chemical agents from certain drugs, pesticides, and industrial by-products that mimic endogenous hormones or can interfere with endocrine disruptors. These chemical compounds can cause an effect on several developmental anomalies to humans. It can also interfere with the production and metabolism of ovarian estrogen in females.
Conclusion
Endocrine disruptors can interfere with the body’s endocrine system causing a health risk to an individual. EDC (endocrine-disrupting chemicals) can target many different organs and systems of the body by various factors that the human body is being exposed to. One of the EDC factors is obesogen, and it can cause a person to gain weight and be obese. Another factor is the exposure of PAHs (polycyclic aromatic hydrocarbons) through environmental factors like smoke inhalation or consuming charcoal-broiled meats. There are ways to cope with EDC exposure, and one is eating organic foods, especially fresh fruits and vegetables. Another is products that target the endocrine system and helps support the liver, intestines, body metabolism, and estrogen metabolism to ensure not only a healthy endocrine system but also a healthy body to function correctly.
October is Chiropractic Health Month. To learn more about it, check out Governor Abbott’s proclamation on our website to get full details on this historic event.
The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or chronic disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .
References:
Cardoso, A M, et al. �Obesogens and Male Fertility.� Obesity Reviews : an Official Journal of the International Association for the Study of Obesity, U.S. National Library of Medicine, Jan. 2017, www.ncbi.nlm.nih.gov/pubmed/27776203.
Darbre, Philippa D. �Endocrine Disruptors and Obesity.� Current Obesity Reports, Springer US, Mar. 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5359373/.
Holtcamp, Wendee. �Obesogens: an Environmental Link to Obesity.� Environmental Health Perspectives, National Institute of Environmental Health Sciences, Feb. 2012, www.ncbi.nlm.nih.gov/pmc/articles/PMC3279464/.
Janesick, Amanda S, and Bruce Blumberg. �Obesogens: an Emerging Threat to Public Health.� American Journal of Obstetrics and Gynecology, U.S. National Library of Medicine, May 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC4851574/.
Janesick, Amanda S, and Bruce Blumberg. �Obesogens: an Emerging Threat to Public Health.� American Journal of Obstetrics and Gynecology, U.S. National Library of Medicine, May 2016, www.ncbi.nlm.nih.gov/pubmed/26829510.
L�r�nd, T, et al. �Hormonal Action of Plant Derived and Anthropogenic Non-Steroidal Estrogenic Compounds: Phytoestrogens and Xenoestrogens.� Current Medicinal Chemistry, U.S. National Library of Medicine, 2010, www.ncbi.nlm.nih.gov/pubmed/20738246.
Patisaul, Heather B, and Wendy Jefferson. �The Pros and Cons of Phytoestrogens.� Frontiers in Neuroendocrinology, U.S. National Library of Medicine, Oct. 2010, www.ncbi.nlm.nih.gov/pmc/articles/PMC3074428/.
Singleton, David W, and Sohaib A Khan. �Xenoestrogen Exposure and Mechanisms of Endocrine Disruption.� Frontiers in Bioscience : a Journal and Virtual Library, U.S. National Library of Medicine, 1 Jan. 2003, www.ncbi.nlm.nih.gov/pubmed/12456297.
Unknown, Unknown. �Endocrine Disruptors.� National Institute of Environmental Health Sciences, U.S. Department of Health and Human Services, 2015, www.niehs.nih.gov/health/topics/agents/endocrine/index.cfm.
Unknown, Unknown. �Polycyclic Aromatic Hydrocarbons (PAHs): Your Environment, Your Health | National Library of Medicine.� U.S. National Library of Medicine, National Institutes of Health, 31 Apr. 2017, toxtown.nlm.nih.gov/chemicals-and-contaminants/polycyclic-aromatic-hydrocarbons-pahs.
Yang, Oneyeol, et al. �Endocrine-Disrupting Chemicals: Review of Toxicological Mechanisms Using Molecular Pathway Analysis.� Journal of Cancer Prevention, Korean Society of Cancer Prevention, 30 Mar. 2015, www.jcpjournal.org/journal/view.html?doi=10.15430%2FJCP.2015.20.1.12.
Biotransformation is the process of a substance changes from one chemical to another being transformed by a chemical reaction within the body. In the human body though, biotransformation is the process of rendering nonpolar (fat-soluble) compounds to polar (water-soluble) substances so they can be excreted in urine, feces, and sweat. It also serves as an important defense mechanism in the body to eliminate toxic xenobiotics out of the body through the liver. The liver is the one that takes these toxins and transformed them into suitable compounds to excrete out of the body as biotransformation.
Detoxification is also known as �detoxication� in literature. It is also a type of alternative medicine treatment that aims the body to get rid of unspecified �toxins.� It is highly important for a person to detox their body and with biotransformation, it can be classified into two categories, under normal sequences, which tends to react with a xenobiotic. They are called Phase 1 and Phase 2 reactions that help the body with detoxification.
Phase 1 Reactions
Phase 1 reaction is consisting of oxidation-reduction and hydrolysis. Research shows that Phase 1 is generally the first defense employed by the body to biotransform xenobiotics, steroid hormones, and pharmaceuticals. They create CYP450 (cytochrome P450) enzymes and are described as functionalization microsomal membrane-bound that are located in the liver but can also be in enterocytes, kidney, lungs and the brain in the body. The CYP450 enzymes can be beneficial or have consequences for an individual�s response to the effect of a toxin they are exposed to.
Studies have been shown that phase 1 reactions have been affecting the elderly population. It states that hepatic phase 1 reaction involving oxidation, hydrolysis, and reduction appears to be more altered by age since the elderly population comprises the fastest-growing segment of the world�s population. It also states that there is a predictable, age-related decline in cytochrome P-540 function and combined with the polypharmacy that much of the elderly population experiences, this may lead to a toxic reaction of medication.
Phase 2 Reaction
Phase 2 reaction is part of the cellular biotransformation machinery and is a conjugation reaction in the body. They can involve the transfer of a number of hydrophilic compounds to enhanced the metabolites, and the excretion in the bile or urine in the body. The enzymes in Phase 2 reaction can also comprise multiple proteins and subfamilies to play an essential role in eliminating the biotransformed toxins and metabolizing steroid hormones and bilirubin in the body.
Phase 2 enzymes can function not only in the liver but also in other tissues like the small intestines. When it combined with Phase 1, they can help the body naturally detox the toxins that the body may encounter. Hormones, toxins, and drugs undergo a hepatic transformation by Phase 1 and Phase 2 pathways in the liver, then are eliminated by phase 3 pathways.
Xenobiotics
Xenobiotics has been defined as chemicals that undergo metabolism and detoxication to produce numerous metabolites, some of which have the potential to cause unintended effects such as toxicity. They can also block the action of enzymes or receptors used for endogenous metabolism and produce liver damage to a person. Xenobiotics like drugs, chemotherapy, food additives, and environmental pollutants can generate serval free radicals that lead to an increase of oxidative stress in the cells. Accumulation of oxidative stress in the body can lead to an increase in potential cellular reduction in the body.
Research shows that the body has a major challenge when it is detoxifying xenobiotics out of the body system and the body must be able to remove the almost-limitless number of the xenobiotic compounds from the complex mixture of chemicals that are involved in normal metabolism.
Studies even show that if the body doesn�t have a normal metabolism, many xenobiotics would reach toxic concentrations. It can even reach the respiratory tract either through airborne toxins or the bloodstream. It is important to make sure that the body and especially the liver to be healthy. Since the liver is the largest internal organ, it is responsible for detoxifying the toxins out of the body as urine, bile, and sweat.
Conclusion
Biotransformation is the process of substance changes from one chemical to another. In the body, it is a process of rendering fat-soluble compounds to water-soluble compounds, so it can be excreted out of the body as either urine, feces, or sweat. The liver is the one that causes toxic xenobiotics to transform into biotransformation and going through phase 1 and 2 to excrete the toxins out of the body for a healthy function.
Phase 1 reactions in the body are the first line of defense of the body detoxifying itself. Phase 2 creates CYP450 (cytochrome P450) that helps the body take the xenobiotic toxins and oxidates to reduce and hydrolysis the toxins to metabolites. Those metabolites then transform into Phase 2 reactions, which conjugates the metabolites in the body to be excreted out of the body. There are many factors that can make the body have xenobiotics, but the liver is the main organ to detoxify the xenobiotics out of the system. If there is an abundance of xenobiotics in the body, it can cause toxicity reaction causing the body to develop chronic illnesses. These products are known to help support the intestines and liver detoxication as well as, to help support hepatic detoxication for optimal healthy body function.
October is Chiropractic Health Month. To learn more about it, check out Governor Abbott�s bill on our website to get full details.
The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or chronic disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .
References:
Chang, Jyh-Lurn, et al. �UGT1A1 Polymorphism Is Associated with Serum Bilirubin Concentrations in a Randomized, Controlled, Fruit and Vegetable Feeding Trial.� The Journal of Nutrition, U.S. National Library of Medicine, Apr. 2007, www.ncbi.nlm.nih.gov/pubmed/17374650/.
Croom, Edward. �Metabolism of Xenobiotics of Human Environments.� Progress in Molecular Biology and Translational Science, U.S. National Library of Medicine, 2012, www.ncbi.nlm.nih.gov/pubmed/22974737.
Hindawi, Unknown. �Xenobiotics, Oxidative Stress, and Antioxidants.� Xenobiotics, Oxidative Stress, and Antioxidants, 17 Nov. 2017, www.hindawi.com/journals/omcl/si/346976/cfp/.
Hodges, Romilly E, and Deanna M Minich. �Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review with Clinical Application.� Journal of Nutrition and Metabolism, Hindawi Publishing Corporation, 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC4488002/.
Kaye, Alan D, et al. �Pain Management in the Elderly Population: a Review.� The Ochsner Journal, The Academic Division of Ochsner Clinic Foundation, 2010, www.ncbi.nlm.nih.gov/pmc/articles/PMC3096211/.
panelEdwardCroom, Author links open overlay, et al. �Metabolism of Xenobiotics of Human Environments.� ScienceDirect, Academic Press, 11 Sept. 2012, www.sciencedirect.com/science/article/pii/B9780124158139000039.
Sodano, Wayne, and Ron Grisanti. �The Physiology and Biochemistry of Biotransformation/Detoxification.� Functional Medicine University, 2010.
Unknown, Unknown. �ToxTutor – Introduction to Biotransformation.� U.S. National Library of Medicine, National Institutes of Health, 2017, toxtutor.nlm.nih.gov/12-001.html.
Prostaglandins are different than hormones. They are not secreted from a gland that can be carried through the bloodstream and work on specific areas around the body. Prostaglandins are made by a chemical reaction in the body that can be made in all the organs and are part of the body�s way of dealing with injuries and illnesses.
When any part of the body has been damaged, prostaglandins are made at the site of tissue damage or infection where they cause inflammation, pain and fever as part of the body�s healing process. When there is a high level of prostaglandins in the body due to the natural healing process from injuries and inflammation, it can contribute to several diseases from the unwanted inflammation.
Prostaglandins in the Omega fatty acids
In omega-6 fatty acids, DGLA (dihomo-gamma-linolenic acid) creates Prostaglandin E1(PG-1) as anti-inflammatory receptors in the body. In omega-3 fatty acids, they can create Prostaglandin E3 (PG-3) that are also anti-inflammatory receptors as well. PG-1 and PG-3 help prevent blood clotting in the body system.
When it comes to pro-inflammatory receptors, omega-6 fatty acids have these receptors as well. Pro-inflammatory receptors are created by arachidonic acid. Arachidonic acid creates Prostaglandin E2 (PG-2), which is responsible for inflammation, swelling and clotting as well.
There has to be a balance between PG-2 and PG-1,3 to provide a healthy function in the body and an ideal hormone signaling response. When one of the PGs are being disrupted by trans-fatty acids from food, it can cause health problems to a person.
Deficiencies in Prostaglandins
Trans fatty acids are a form of unsaturated fats that can be either natural or artificial. They are produced either by hydrogenation of unsaturated oils or by biohydrogenation in the stomach of ruminant animals. Numerous studies have been shown that consuming trans fatty acids continuously can increase the risk of cardiovascular diseases. This can also increase the ratio of LDL cholesterol to HDL cholesterol in the body. Trans fatty acids can block the activity of D6D (delta-6-desaturase), which is the first step in prostaglandin synthesis from essential fats in the diet.
The excess sugar consumption, insulin surges, inflammation, protein deficiencies hypothyroidism, and alcohol consumption will impair the activity of D6D and be a marker of accelerating aging to the human body. When a person has an increased consumption from fried foods and vegetable oils in an Western diet will shift the omega-6 pathway from PG-1 and into PG-2 production in the body. With the current American diet, people consume a high quantity of omega-6 fatty acids and low quantity of omega-3 fatty acids. This will cause a strong reaction of an inflammatory prostaglandin shift.
Since prostaglandins are caused by injuries and inflammation to heal the body, when an individual consumes a high omega-6 diet, it can cause an excessive amount of inflammation to the body and it can lead to chronic illnesses.
More Deficiencies in Prostaglandins
A deficiency in nutrients like nicotinic acid, pyridoxal 5� -phosphate, calcium, magnesium, zinc, and molybdenum is required for the desaturase and elongase enzymes in omega-6 and omega-3 fatty acids. Their deficiency can lead to improper production of prostaglandins. So EFAs from diets cause overconsumption of omega-6 and a lack of essential fatty acids in the body.
After that happens, then the EFAs can be synthesized into prostaglandins with desaturase and elongase enzymes. This will then cause nutrient deficiencies and metabolic factors can impair and downregulate those enzymes and causing the body to be prone to pro-inflammatory.
When that happens, prostaglandin formation will suddenly turn into abnormal ratios in the body causing problems, excessive inflammation in the endocrine glands and the body organs, and soon later on if it is not fixed, chronic illnesses will cause proper hormones to alter their components and either stop producing or create an abundance in the body.
Conclusion
Prostaglandins are a chemical reaction to the body that are different than hormones. They are caused when the body is injured and it causes inflammation so it can naturally heal itself. When there is an excessive amount of prostaglandins in the body it can lead to chronic inflammation and cause an abnormal shift in the body�s functional state. A factor that can affect the prostaglandins as well is the excessive consumption of omega-6 fatty acids. This consumption can cause inflammation and can make the body feel sluggish and not feeling great. There are products that can help the body, especially balancing the production of essential fatty acids and metabolizing the body for optimal health.
October is Chiropractic Health Month. To learn more about it, check out Governor Abbott�s bill on our website to get full details.
The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or chronic disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .
References:
F.Horrobin, David. �Loss of Delta-6-Desaturase Activity as a Key Factor in Aging.� Medical Hypotheses, Churchill Livingstone, 22 Mar. 2004, www.sciencedirect.com/science/article/abs/pii/0306987781900645.
Horrobin, D F. �Fatty Acid Metabolism in Health and Disease: the Role of Delta-6-Desaturase.� The American Journal of Clinical Nutrition, U.S. National Library of Medicine, May 1993, www.ncbi.nlm.nih.gov/pubmed/8386433.
Innes, Jacqueline K, and Philip C Calder. �Omega-6 Fatty Acids and Inflammation.� Prostaglandins, Leukotrienes, and Essential Fatty Acids, U.S. National Library of Medicine, May 2018, www.ncbi.nlm.nih.gov/pubmed/29610056.
Iqbal, Mohammad Perwaiz. �Trans Fatty Acids – A Risk Factor for Cardiovascular Disease.� Pakistan Journal of Medical Sciences, Professional Medical Publicaitons, Jan. 2014, www.ncbi.nlm.nih.gov/pmc/articles/PMC3955571/.
Leech, Joe. �What Are Trans Fats, and Are They Bad for You?� Healthline, 30 July 2019, www.healthline.com/nutrition/why-trans-fats-are-bad.
Ricciotti, Emanuela, and Garret A FitzGerald. �Prostaglandins and Inflammation.� Arteriosclerosis, Thrombosis, and Vascular Biology, U.S. National Library of Medicine, May 2011, www.ncbi.nlm.nih.gov/pmc/articles/PMC3081099/.
Tallima, Hatem, and Rashika El Ridi. �Arachidonic Acid: Physiological Roles and Potential Health Benefits – A Review.� Journal of Advanced Research, Elsevier, 24 Nov. 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC6052655/.
Unknown, Unknown. �Prostaglandins.� You and Your Hormones, Dec. 2016, www.yourhormones.info/hormones/prostaglandins/.
Wang, Xiaoping, et al. �Multiple Roles of Dihomo-?-Linolenic Acid against Proliferation Diseases.� Lipids in Health and Disease, BioMed Central, 14 Feb. 2012, www.ncbi.nlm.nih.gov/pmc/articles/PMC3295719/.
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