Back Clinic Metabolic Syndrome Functional Medicine Team. This is a group of conditions that include increased blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol or triglyceride levels. These occur together, increasing an individual’s risk of heart disease, stroke, and diabetes. Having just one of these conditions doesn’t mean an individual has metabolic syndrome. However, any of these conditions increase the risk of serious disease. Having more than one of these might increase the risk even more. Most of the disorders associated with metabolic syndrome have no symptoms.
However, a large waist circumference is a visible sign. In addition, if an individual’s blood sugar is very high, they might have signs and symptoms of diabetes, including increased thirst, urination, fatigue, and blurred vision. This syndrome is closely linked to overweight/obesity and inactivity. It’s also linked to a condition called insulin resistance. Normally, the digestive system breaks down foods into sugar (glucose). Insulin is a hormone made by the pancreas that helps sugar enter the cells to fuel. People with insulin resistance their cells don’t normally respond to insulin, and glucose can’t enter the cells as easily. As a result, glucose levels in the blood rise despite the body’s attempt to control the glucose by churning out more and more insulin.
Dr. Alex Jimenez, D.C., presents how many people can recognize the cause of metabolic syndrome. Metabolic syndrome is a cluster of conditions ranging from insulin resistance to muscle and joint pain. Considering how every person is different, we look at how metabolic syndrome is associated with cardiovascular disorders. We refer patients to certified providers that provide cardiovascular treatments associated with metabolic syndrome to relieve issues affecting the body while ensuring optimal wellness for the patient through various treatments. We acknowledge each patient by referring them to our associated medical providers based on their diagnosis to understand better what they are dealing with appropriately. We understand that education is an excellent way to ask our providers various intricated questions to the patient’s knowledge. Dr. Jimenez, D.C., utilizes this information as an educational service. Disclaimer
What Is Metabolic Syndrome?
Dr. Alex Jimenez, D.C., presents: Today, we are going to start widening the lens on metabolic syndrome. From a functional medicine perspective, many didn’t always call it metabolic syndrome. Other terms used to describe the diagnosis were:
Dysmetabolic syndrome
Hypertriglyceridemic waist
Insulin resistance syndrome
Obesity syndrome
Syndrome X
Metabolic syndrome is a cluster of disorders that can affect an individual’s daily life and cause various issues that can cause the body to be dysfunctional. So in 2005, the ATP three guidelines told us that patients must meet three out of five criteria to get the diagnosis of metabolic syndrome. So these are around waist circumference, which is about visceral adiposity, blood pressure, blood glucose, triglycerides, and HDL. And then you see the cutoffs there. So in the International Diabetes Federation diagnosis criteria, notice that it’s required to have central obesity, but per ethnicity-specific cutoffs for waist circumference. So instead of three out of five, you have to have one, and then the other two out of four must be met. So you see the other ones the same as before, but they’re just compartmentalized differently in this diagnosis scheme. Now let’s talk about these ethnicity-specific cutoffs.
So if you are a standard corn-fed American, your waist circumference cutoff is 40 inches as a male and 35 inches as a female. Now, if you were from different parts of the world, the numbers for waist circumference are different whether the ethnicity is Asian, Hispanic, African, European, or Middle Eastern. By looking at the diagnosis of metabolic syndrome by looking more into the ethnicity-specific cutoffs, you can see that more people would start to meet the criteria for metabolic syndrome if doctors use the stringent ethnicity-specific standards to diagnose their patients for metabolic syndrome. Other diagnoses would also notice where the visceral adiposity is at during the cutoff and see additional hints of insulin resistance. Other factors besides insulin resistance can cause the body’s systems to be dysfunctional, which will drive the common risk factors to cause the pain associated with metabolic syndrome to affect the muscles and muscle groups. When the body becomes dysfunctional due to metabolic syndrome, it can also affect vital organ systems like the cardiovascular system. Now how does metabolic syndrome correlate with the cardiovascular system?
How Does Metabolic Syndrome Associated With Cardiovascular System?
Dr. Alex Jimenez, D.C., presents: If you look at how a person’s lifestyle habits affect their body, you can see that the data shows how metabolic factors contribute to total cardiometabolic risk. This information lets the doctors and patients know about their LDL cholesterol, BMIs, family history, and blood pressure. Suppose a person has pre-existing cardiovascular issues associated with metabolic syndrome. In that case, it is important to know if their glucose levels have elevated or dropped and to see how to control those risk factors associated with cardiometabolic syndrome. These are important risk factors that have to be brought up in a metabolic dysfunction conversation to have a better understanding.
Now there are ways to reduce the effects of metabolic syndrome associated with cardiovascular diseases. By expanding the data from the patient’s test results, we can look beyond the cardiometabolic risk; we can determine the causes that are the progression of these issues affecting the body. This can be numerous issues like how much exercise the person is doing, how they deal with stress and inflammation, and what foods they eat.
By recognizing these results, we can identify things beyond metabolic syndrome and figure out what other disorders are contributing to metabolic syndrome. Many doctors will inform their patients about how their insulin levels can become elevated, which can cause them to develop insulin resistance and lose their beta cells. When insulin resistance corresponds with metabolic syndrome, many people need to realize that their genes can also play into effect. Some people have genes that drive them with the same kind of lifestyle dysfunction, inflammation, dysfunction, and insulin resistance. Their genes will also equal blood pressure issues or crazy lipid disturbances. When cardiometabolic risk factors are contributing to underlying problems affecting the body, it is really important to have functional medicine be the main focus to figure out where the issues are causing dysfunction in the body.
Insulin Resistance & Metabolic Syndrome
Dr. Alex Jimenez, D.C., presents: So when it comes to insulin resistance, it is important to take note of the abnormal beta cell function in the body if the pancreas can’t produce enough insulin to be turned into glucose. When this happens, people will begin to have elevated glucose levels, and if it continues to rise at a certain point, they will already be prone to having type 2 diabetes. To that point, the body will have this relative insulin deficiency, causing the body’s receptors not to be as sticky and functional.
When enough insulin is circulating the body and doing its job, the blood glucose levels don’t hit the threshold to become diabetes. Now, suppose the body maintains normal beta cell function. In that case, however, the insulin receptors are not working, which allows the pancreas to start pumping out insulin to be able to keep up with this resistance, causing the individual to be at a compensatory high insulin state. By stabilizing insulin levels, many individuals can control how much glucose is in their bodies. However, suppose a person is prone to becoming diabetic. In that case, all that insulin is being pumped out is a massive system biology dysfunction signaling many other nondiabetic downstream diseases.
Conclusion
So insulin dysfunction can be associated with cardiovascular disease due to poor lifestyle choices, dietary habits, and physical activity. When dealing with metabolic syndrome associated with these risk factors, it can cause the body to be dysfunctional and cause pain in the organs, muscles, and joints. This can lead to obesity and diabetes if it is not handled properly. Getting a routine started can help lower insulin resistance by eating properly, getting adequate sleep, practicing mindfulness, and exercising can help improve the body and mind.
Dr. Alex Jimenez, D.C., presents how the cause and effects of cardiometabolic risk can affect a person’s health and wellness. Cardiometabolic syndrome can affect any person through lifestyle factors and cause pain-like symptoms that can affect their well-being. We refer patients to certified providers that provide cardiovascular treatments associated with metabolic syndrome to relieve issues affecting the body while ensuring optimal wellness for the patient through various treatments. We acknowledge each patient by referring them to our associated medical providers based on their diagnosis to understand better what they are dealing with appropriately. We understand that education is an excellent way to ask our providers various intricated questions to the patient’s knowledge. Dr. Jimenez, D.C., utilizes this information as an educational service. Disclaimer
The Cause & Effects Of Cardiometabolic Risk
Dr. Alex Jimenez, D.C., presents: Now, as we enter this new era, many individuals are trying to find ways of managing cardiometabolic risk. So in this presentation, we will look at the number one killer in many modern countries; cardiovascular disease is defined as a cluster of conditions that affect the heart. Many factors are associated with cardiovascular disease that overlaps with metabolic syndrome. The word cardiometabolic hints that we will discuss something broader than cardiovascular risk.
The goal is to gain perspective on the old conversation about the cardiovascular risk associated with the circulatory system. We all know that the body’s circulatory, respiratory, and skeletal systems have different compartments that have different jobs to make the body functional. The problem is that the body operates in various systems independent of each other. They come together and interconnect like a web.
The Circulatory System
Dr. Alex Jimenez, D.C., presents: So the circulatory system helps transport blood vessels and allows the lymphatic vessels to carry cells and other items like hormones from one place to another. An example would be your insulin receptors moving information throughout your body and your glucose receptors being utilized for energy. And obviously, all other types of communicators govern how transportation happens in the body. Now the body is not a closed fixed circuit connected through the outside. Many factors can influence the body inside and outside that can affect the arterial wall and cause overlapping issues affecting the cardiovascular system. Now, what is happening to the arterial wall causing overlapping matters in the body?
When factors start to affect the arterial wall inside, it can cause plaque to form in the arterial walls and even affect the integrity of the outer walls of the arteries. When this happens, LDL or low-density lipoprotein could grow in size and cause a spike in cholesterol levels. To that point, when the body is dealing with poor lifestyle habits, it can influence the body to be at high cardiovascular risk. When the body is dealing will cardiovascular diseases at high risk, it can cause correlate to high blood pressure, diabetes, or metabolic syndrome. This causes the body to have muscular and joint pain in the back, neck, hips, and chest, to name a few, and can cause the individual to deal with inflammation in the gut, joints, and muscles.
Factors Associated With Cardiometabolic Risk Factors
Dr. Alex Jimenez, D.C., presents: But, interestingly, it’s not until recently that institutions that govern our standard of care are taking this seriously, saying it needs to be a part of the guidelines because the data is so evident that how a person’s lifestyle matters when it comes to their health. The data can range from the correlation of how certain diets, like the Mediterranean diet, can change a person’s nutritional habits. To how stress is associated with cardiometabolic disorders. Or how much exercise or sleep you are getting. These environmental factors correlate to how cardiometabolic risk factors affect the body. By informing patients what is going on with their bodies, they can finally make small changes to their lifestyle habits. Now let’s look at how nutrition can impact a person with cardiometabolic risk profiles.
By having a conversation about nutrition, many people can see the impact of the standard American diet and how it can lead to a caloric increase in central adiposity. When conversing about nutrition, it is best to note what the person is eating, causing cardiometabolic risk issues in their bodies. Doctors work with nutritionists to devise a solution to implement the right amount of protein the individual needs, how much vegetables and fruits they can consume, and what food allergies or sensitivities to avoid. To that point, informing patients about eating healthy, organic, and nutritional food will allow them to understand what they put in their bodies and how to reverse the effects. Now each person is different as certain diets are for some people while others don’t, and it is also important that by advising patients about what they are taking in and consuming but also about timing. Some people do fasting to cleanse their bodies of toxins and allow the body’s cells to find different ways to consume energy.
How Nutrition Plays A Role In Cardiometabolic Syndrome
Dr. Alex Jimenez, D.C., presents: But did you know the quality of calories in the standard American diet can damage our intestinal lining, making it vulnerable to permeability, creating this very common scenario called metabolic endotoxemia that triggers inflammation? The quality and quantity of foods can disrupt our microbiome, leading to dysbiosis as a different mechanism of inflammation. And so you get this immune activation and dysregulation that makes a constant bath in which your genes are bathing. Inflammation can be good or bad depending on the severity of what is happening in the body. If the body suffers from an injury or deals with minor issues, inflammation can help heal. Or if the inflammation is severe, it can cause the intestinal wall lining to become inflamed and leak out toxins and other microbes into the rest of the body. This is known as a leaky gut, potentially leading to muscle and joint pain associated with obesity. So we want to broaden that conversation around nutrition because obesity impacts poor nutrition. It’s commonly said that we are overfed and undernourished as a human population. So we want to be able to mitigate the trends of obesity responsibly. And we want to bring in this larger conversation about social determinants of health. As the years go by, many people are more aware of how their environment and lifestyle play a role in developing cardiovascular or cardiometabolic conditions.
We must recognize that the human body lives in this social ecosystem that determines the health potential. We want to engage the patient to bring awareness to the most potent anti-inflammatory signal into their lives and their lifestyle choice. And we are not discussing fads like putting on spandex and going to the gym once a month; we’re talking about daily movement and how to reduce sedentary behavior associated with the cardiometabolic syndrome. We discussed how even the impact of stress could promote atherosclerosis, arrhythmias, and metabolic dysfunction in the body and cause various issues that can affect a person’s well-being.
Stress & Inflammation’s Role In The Body
Dr. Alex Jimenez, D.C., presents: Stress, like inflammation, can be good or bad, depending on the scenario. So stress can impact a person’s ability to function in the world as we dive into the systems biology dysfunctions that occur from acute and chronic stress and how we can help our patients. We must understand that we should put ourselves in our patient’s shoes by figuring out how to lower chronic stress to reduce cardiometabolic risk factors and improve quality of life.
So by not being so fixated on trying everything at once to reduce cardiometabolic risk factors, taking everything that we learn and incorporating it slowly into our daily lives can make a huge impact on how we look, feel, and what we eat can improve our well-being. Dr. David Jones stated, “If all we do is talk about this and all we do is know this stuff, it doesn’t do the full service we have as an intention for our patients.”
We must get ourselves from the knowing stage into the doing stage because that’s when results will occur. So by looking at the bigger picture, we can take back our health from cardiometabolic syndrome by focusing on where the problem is happening in our bodies and going to various specialists that can develop a treatment plan to lower the stress and inflammation in our bodies that can reduce the effects of cardiometabolic syndrome.
Conclusion
Dr. Alex Jimenez, D.C., presents: So if many people are dealing with cardiometabolic risks, they have these very common systems, biology dysfunctions, whether it’s related to inflammation, oxidative stress, or insulin dysfunction, are all happening under the surface. . In functional medicine, we want to go upstream in this new era of cardiometabolic health. We want to leverage the environment and lifestyle to manipulate the system’s biology so it can be in a favorable setting to allow the epigenetic potential of the patient to be at its highest expression of health.
By providing the right tools for the patients, many functional medicine doctors can educate their patients on how to take back their health a little bit each time. For example, a person is dealing with chronic stress, causing stiffness in their necks and backs, making them unable to move around. Their doctors can devise a plan to incorporate meditation or take a yoga class to ease the stress out of their bodies and become mindful. So by gathering important clinical information about how a person is suffering from cardiometabolic, many doctors can work with their associated medical providers to devise a treatment plan to cater to each suffering from symptoms associated with cardiometabolic.
Dr. Alex Jimenez, D.C., presents how various treatments can help with adrenal insufficiency and can help regulate hormone levels in the body in this 2-part series. Since hormones play a vital role in the body by controlling how the body functions, it is important to know what the trigger is that is causing overlapping issues in the body. In Part 1, we looked at how adrenal insufficiencies affect different hormones and their symptoms. We refer patients to certified providers that include hormone treatments that relieve adrenal insufficiencies affecting the body while ensuring optimal health and wellness for the patient through various therapies. We appreciate each patient by referring them to associated medical providers based on their diagnosis when it’s appropriate to understand better what they are feeling. We understand that education is an excellent and inquisitive way to ask our providers various intricated questions at the patient’s request and knowledge. Dr. Jimenez, D.C., utilizes this information as an educational service. Disclaimer
Treatments For Adrenal Insufficiencies
Dr. Alex Jimenez, D.C., presents: When it comes to adrenal insufficiencies, the body has various symptoms that can cause the person to feel low on energy and pain in different areas. Since hormones are produced in the adrenal glands, they help maintain how vital organs and muscles work to keep the body functional. When various factors affect the body, disrupting the adrenal glands, it can cause hormone production to over or underproduce. To that point, it can correlate to numerous symptoms that cause the body to be dysfunctional. Fortunately, there are various treatments that many people can incorporate into their daily lives to promote hormone regulation.
Now everyone has different ways to lower their stress, which is fine as there are various treatments that a person may like to try, and if they are in a treatment plan that their doctor developed for them, they can find ways to get their health and wellness back. Many individuals sometimes participate in meditation and yoga to practice mindfulness. Now meditation and yoga have amazing benefits in lowering oxidative stress and cortisol levels associated with chronic stress. By looking at how adrenal insufficiencies can cause an increase in insulin, cortisol, and DHEA dysfunction in the HPA axis, many doctors would devise a treatment plan for their patients that can help lower the oxidative stress markers and regulate hormonal production. So if one of the treatments is meditation or yoga, many individuals who practice yoga and meditation will begin to notice how they are feeling after taking a few deep breaths and begin to feel mindful of their surroundings. This causes many people to improve their quality of life associated with decreased cortisol levels.
How Mindfulness Can Lower Stress
Dr. Alex Jimenez, D.C., presents: Another available treatment that can help with adrenal insufficiencies is an 8-week mindfulness treatment that can help lower cortisol levels from escalating in the body to cause more issues than a person is dealing with. Depending on what stage the HPA axis dysfunction is affecting the body, taking the time for yourself can benefit you in the long run. An example would be taking a hike on a nature walk path. The change in the environment can help a person relax and be at ease. This allows the body to let go of unnecessary pent-up stress affecting a person’s mood, functionality, and mental health when a change of scenery can help them relax and recharge. To that point, it allows the HPA axis to relax as well.
Another example of how mindfulness can help treat adrenal insufficiencies associated with hormonal dysfunction is by providing neurofeedback to those with chronic PTSD. Individuals with traumatic experiences have PTSD, which can hinder their ability to function in the world. When they go through a PTSD episode, their bodies will begin to lock up and tense, causing their cortisol levels to rise. To that point, this causes an overlap of symptoms associated with muscle and joint pain. Now how does mindfulness plays its part when it comes to treatment? Well, many doctors specializing in treating PTSD will do an EMDR test. EMDR stands for eye, movement, desensitization, and reprogramming. This allows PTSD patients to have their HPA axis rewired and reduce the neuron signals in their brains and help lower any cortisol levels causing adrenal insufficiencies in their bodies. Incorporating EMDR testing into PTSD patients allows them to find the issue causing the trauma through brain spotting, where the brain replays the traumatic memories and helps rewire the brain to release the trauma out of the body and start the healing process.
Vitamins & Supplements
Dr. Alex Jimenez, D.C., presents: Another technique many individuals can begin if they want to regulate their hormones is by taking supplements and neutraceuticals to help replenish hormonal function and the body. Choosing the right vitamins and supplements is not difficult if you don’t want to consume them in pill form. Many vitamins and supplements can be found in nutritious whole foods with specific nutrients that can improve hormone production and make a person feel full. Some of the vitamins and supplements that can help with hormone balance include:
Magnesium
B vitamins
Probiotics
Vitamin C
Alpha-lipoic acid
Omega-3 Fatty Acid
Vitamin D
These vitamins and supplements can help communicate with the other hormones the body produces and help balance hormonal production. Now, these treatments can help many people with hormonal imbalances in their bodies, and there are times when the process can be tough. Just remember that making these small changes can have a huge effect in the long run regarding your health and wellness. By sticking with the treatment plan that your doctor has come up with you, you will feel better over time and take back your health as well.
Dr. Alex Jimenez, D.C., presents how adrenal insufficiencies can affect the hormone levels in the body. Hormones play a vital part in regulating body temperature and help function the vital organs and muscles. This 2-part series will examine how adrenal insufficiencies affect the body and its symptoms. In part 2, we will look at the treatment for adrenal insufficiencies and how many people can incorporate these treatments into their health and wellness. We refer patients to certified providers that include hormone treatments that relieve various issues affecting the body while ensuring optimal health and wellness for the patient. We appreciate each patient by referring them to associated medical providers based on their diagnosis when it’s appropriate to understand better what they are feeling. We understand that education is an excellent and inquisitive way to ask our providers various intricated questions at the patient’s request and knowledge. Dr. Alex Jimenez, D.C., utilizes this information as an educational service. Disclaimer
What Are Adrenal Insufficiencies?
Dr. Alex Jimenez, D.C., presents: Many factors can affect the body, whether eating habits, mental health, or lifestyle habits all play a role in maintaining hormone function in the body. Today, we will apply these common dysfunctional cortisol patterns that patients present when they go in for a daily examination. Most patients often come in and explain to their doctors that they are suffering from adrenal dysfunction because different symptoms are associated with various stages of adrenal dysfunction or HPA dysfunction. Now adrenal dysfunction or hypothalamic pituitary adrenal (HPA) dysfunction is when the adrenal glands are not producing enough hormone to regulate the body. This causes the body to go through different stages of adrenal dysfunction if it is not treated right this way, causing the body to deal with muscle and joint pain that a person hasn’t dealt with throughout their life.
Many doctors and healthcare providers use a systematic approach that can help many people address whether or not they have adrenal dysfunction in their bodies. Today, we will discuss the relationship between female hormones and mood disorders associated with adrenal dysfunction. When it comes to adrenal dysfunction associated with hormones, many people will often get medicated for mental illnesses like bipolar disease or depression when their hormones are imbalanced. When hormonal imbalances begin to affect women in their early fifties due to premenopause, the mental disorder would often worsens and cause many other overlapping issues that can affect their hormones and their bodies.
Adrenal Dysfunction Affect The Body
Dr. Alex Jimenez, D.C., presents: Many women would have healthy diets, take yoga, be involved in spiritual practices, and hang out with their friends; however, when their hormone levels are imbalanced, they are dealing with other issues associated with HPA imbalances or adrenal dysfunction. By looking at the 24-hour corticotropic activity and determining how the circadian rhythm controls it, many doctors can look at the data presented to the patient. The way the data is being presented to the patient on how their hormone levels fluctuate in the body in the morning and how they rise or decrease throughout the entire day until they go to sleep.
With this information, many doctors can diagnose why this individual is having trouble going to sleep, constantly waking up early in the night, or not getting enough rest, making them exhausted throughout the day. So how is adrenal dysfunction associated with 24-hour corticotropic activity? Many factors can cause adrenal dysfunction in the body and affect hormone levels. When the body begins to over or underproduces hormones from the adrenal glands or the thyroids, it can cause cortisol and insulin levels to lose control in the body and cause various issues that result in muscle and joint pain. Sometimes hormonal dysfunction can cause somato-visceral or visceral-somatic pain by affecting the vital organs like the gut and the brain and start to cause issues to the surrounding muscles and joints. When the surrounding muscles and joints are causing pain in the body, they could be causing overlapping issues that can affect a person’s mobility and make them miserable.
How To Diagnose Adrenal Insufficiencies?
Dr. Alex Jimenez, D.C., presents: When doctors diagnose a patient suffering from adrenal dysfunction will begin to look at the patient’s medical history. Many patients will start filling out a long, extensive questionnaire, and doctors will begin to look at the anthropometrics, biomarkers, and clinical indicators found in physical exams. Doctors must obtain the patient’s history to look for the signs and symptoms of HPA dysfunction and adrenal dysfunction to determine the issue affecting the individual. After the examination, doctors would use functional medicine to look at where the dysfunction lies in the body and how the symptoms are connected. The numerous factors causing adrenal dysfunction in the body could be how a person’s eating habits are causing these issues, how much exercise they are incorporating in their daily lives, or how stress impacts them.
Functional medicine provides a holistic approach that considers lifestyle components causing issues in the person’s body. By connecting the dots on what the patient is saying and how these factors are causing adrenal insufficiencies, it is important to get the whole story from the patient to devise a treatment plan catered to the individual. They would appreciate that someone finally understands what they are going through and will begin to restore their health and wellness. By looking for the root causes, triggers, and mediators causing adrenal dysfunction, we can look at the expanded history that the patient is telling us, whether it be their family history, their hobbies, or what they like to do for fun. All these things are important to consider to try and connect the dots of the underlying cause of adrenal insufficiencies in the body affecting a person’s hormone levels.
Adrenal Insufficiencies Affect Cortisol
Dr. Alex Jimenez, D.C., presents: Now, do adrenal insufficiencies correlate with increased DHEA and cortisol hormone levels? Well, DHEA is a hormone that is produced by the adrenal glands naturally. DHEA’s main function is to make other hormones like estrogen and testosterone to regulate the male and female body. Cortisol is a stress hormone that increases the glucose levels in the bloodstream. Cortisol’s main function is to allow the brain to use glucose in the body while repairing the affected muscle tissues. When the body begins to over or underproduces hormones from the adrenal glands, it can raise the cortisol levels to cause resilience to the body, and the HPA axis begins to decrease. When this happens, the body starts to feel sluggish, which can cause you to feel exhausted throughout the entire day, even though you may have gotten a good night’s sleep.
Adrenal Insufficiency Symptoms
Dr. Alex Jimenez, D.C., presents: This is known as adrenal fatigue and can be associated with various symptoms that affect the hormone balance in the body. This can include non-specific symptoms like sleep disturbances, digestive issues, fatigue, and body aches can affect the hormone levels inside the body. This causes many individuals to feel miserable due to feeling low energy. Adrenal fatigue can also be associated with the different stages of HPA axis dysfunction. These can include:
Trauma
Food allergies and sensitivities
Dysbiosis
Changes in the gut microbiota
Toxins
Stress
Insulin resistance
Metabolic syndrome
All these issues can affect a person’s hormone levels and cause elevated cortisol to overlap many factors that cause somato-visceral problems. An example would be someone having gut issues associated with chronic stress who can start to feel pain in their joints from the knees, back, and hips which cause their hormone levels can fluctuate.
Dr. Alex Jimenez, D.C., presents an insightful overview of how hormonal dysfunction can affect the body, increase cortisol levels, and be associated with PTSD in this 3-part series. This presentation provides important information to many individuals dealing with hormonal dysfunction associated with PTSD. The presentation also offers different treatment options to reduce the effects of hormonal dysfunction and PTSD through functional medicine. Part 1 looks at the overview of hormonal dysfunction. Part 2 will look at how various hormones in the body contribute to body functionality and how overproduction or underproduction can cause drastic effects on a person’s health. We refer patients to certified providers that incorporate various hormone treatments to ensure optimal health and wellness for the patient. We appreciate each patient by referring them to associated medical providers based on their diagnosis when it is appropriate to have a better understanding. We understand that education is an excellent and inquisitive way to ask our providers various intricated questions at the patient’s request and knowledge. Dr. Alex Jimenez, D.C., utilizes this information as an educational service. Disclaimer
A Look Into Hormonal Dysfunction
Dr. Alex Jimenez, D.C., presents: Now, looking into the exciting didactic here, we will discuss something rare but important to understand when looking at these steroid pathways. And this is something called congenital adrenal hyperplasia. Now, congenital adrenal hyperplasia can occur in the body through an inherited enzyme defect or 21 hydroxylases that can cause a severe decrease in the adrenal production of glucocorticoids. When the body is suffering from congenital adrenal hyperplasia, it can cause an increase in ACTH to make more cortisol.
So when the ACTH increases to make more cortisol in the body, it could lead to muscle and joint pain if it is not treated immediately. We also often think cortisol is bad, but you must have some congenital adrenal hyperplasia when you have the 21 hydroxide deficiency. To that point, your body is not making enough glucocorticoids, causing you to have a high level of ACTH. When there is hormone dysfunction from various environmental triggers, it can cause the hormones in the body to overproduce unnecessary hormones. For example, if you have too much progesterone, it can’t go down to the pathway to make cortisol due to those missing enzymes. It can be converted into androstenedione, causing people to become virilized.
What Happens When The Body Doesn’t Create Enough Hormones?
Dr. Alex Jimenez, D.C., presents: So when patients become virilized, they’re not making any cortisol; it is important to do hormonal therapy to decrease the ACTH stimulation to get the hormone levels back to normal When this happens, it diminishes the stress inside the body system to make more androgens. In the female body, however, progesterone has no peripheral conversion of steroids to be produced except during pregnancy. Progesterone comes from the ovaries and doesn’t get to be produced in the adrenal glands. Progesterone is excreted mostly in urine as many different breakdown products tend to be higher than normal due to that 21 hydroxide deficiency.
So now, let’s talk about androgens in premenopausal women. So the major androgens come from the ovary, the DHEA, androstenedione, and testosterone. At the same time, the adrenal cortex produces glucocorticoids, mineralocorticoids, and sex steroids to make some testosterone and about half of the DHEA hormone. The body also has peripheral conversion responsible for DHEA and testosterone production to normalizing hormone levels. This is due to all the different tissues that have these enzymes to make these various hormones in different concentrations. Premenopausal women are most likely to lose more estrogen after removing their ovaries. This causes them to lose DHEA, androstenedione, and testosterone production in their bodies.
PTSD & Hormonal Dysfunction
Dr. Alex Jimenez, D.C., presents: Now testosterone is carried by SHBG just like estrogen, and many factors that change SHBG are important to testosterone and estrogen. Interestingly, testosterone can decrease SHBG in small amounts to allow the body to have free testosterone, which causes a physiological effect. When it comes to testing for testosterone levels, many people don’t release that when their testosterone levels are elevated, it could be due to low SHBG. By measuring total testosterone in the body, many doctors can determine if their patients are producing too much androgen, which is causing excessive hair growth in their bodies, or they may have low SHBG levels due to hypothyroidism associated with obesity or elevated insulin.
Now when it comes to PTSD, how does it correlate to hormonal dysfunction and affect the body? PTSD is a common disorder many individuals suffer from when they have been through a traumatic experience. When traumatic forces begin to affect the individual, it can cause the cortisol levels to rise and cause the body to be in a state of tension. PTSD symptoms can vary for many individuals; thankfully, various therapies can help lower the symptoms while bringing the hormone levels back to normal. Many healthcare professionals will develop a treatment plan that can help reduce the symptoms of PTSD and help hormone levels function in the body properly.
Treatments To Regulate Hormone
Dr. Alex Jimenez, D.C., presents: Stress in the body can affect the musculoskeletal system by causing the muscle to lock up, leading to issues in the hips, legs, shoulders, neck, and back. Various treatments like meditation and yoga can help lower the cortisol levels from fluctuating higher, causing the body to deal with muscle tension that could overlap with joint pain. Another way to reduce stress in the body is by working out with an exercise regime. Exercising or participating in an exercise class can help loosen up the stiff muscles in the body, and keeping a workout routine can exert any pent-up energy to relieve stress. However, treatments to balance out hormones associated with PTSD can only go so far for many individuals. Eating nutritional, whole foods with vitamins and minerals can help regulate hormone production and provide energy to the body. Dark leafy greens, fruits, whole grains, and proteins can not only help with regulating hormone production. Eating these nutritional foods can also lower inflammatory cytokines that are causing more harm to vital organs like the gut.
Conclusion
Incorporating a healthy diet, an exercise routine, and getting treatment can help many individuals dealing with hormonal dysfunction associated with PTSD. Each person is different, and the symptoms overlap with hormonal dysfunction associated with PTSD and vary from person to person. When doctors work with associated medical providers, it allows them to develop a treatment plan catered to the individual and enables them to regulate their hormone production. Once the hormone production in their bodies is regulated, the symptoms causing the person pain will get better slowly but surely. This will allow the individual to continue on their wellness journey.
Dr. Alex Jimenez, D.C., presents an overview of hormonal dysfunction can affect the various hormones in the body that can increase cortisol levels in this 3-part series. This presentation provides valuable information to many individuals dealing with hormonal dysfunction and how to know the signs and utilize holistic approaches toward their health wellness. Part 1 will look at the overview of hormonal dysfunction. Part 3 will look at various holistic treatments that are available for hormonal dysfunction. We refer patients to certified providers incorporating various hormone therapies to ensure optimal health. We encourage and appreciate each patient by referring them to associated medical providers based on their diagnosis when it is appropriate. We understand that education is an excellent way when asking our providers intricated questions at the patient’s request and understanding. Dr. Alex Jimenez, D.C., only utilizes this information as an educational service. Disclaimer
An Overview Of Hormonal Expression
Dr. Alex Jimenez, D.C., presents: So the classic teaching about hormones is that they’re produced in an endocrine gland and then transported to the cells where the body will utilize them. But things are a little bit more complex. So every cell contains the genes necessary for hormone expression and functionality in the body.
And we know this because when de-differentiated from the late stage, unfortunately, cancer cells uncover gene expression. Those cells make hormones in inappropriate locations and at inconvenient times. So that means that any cell can make any hormones in the body. Still, the hormonal expression of certain genes indicates the presence of certain enzymes, which determines what hormones will reproduce. So, for example, you need to have the right precursors and enzymes. So in a reproductive female, the granulosa cells, the luteinize, and the corpus luteum are produced in the body. The granulosa cells are follicles, while the corpus odium is after ovulation. And these cells start the formation of the steroid hormones in response to FSH and LH. So FSH and LH come from the pituitary glands and stimulate the granulosa cells to start making estrogen. Steroid production will begin if the messaging from FSH and LH gets to the part of the cell that makes estrogen. This allows the body to regulate hormonal production and keep it functional. When issues disrupt hormonal regulation, the body can over or underproduce hormonal production, leading to metabolic issues associated with muscle and joint pain.
So this is a complex process, and there are many areas where this can go wrong. So you can have the right amounts of the hormone, but you’re not getting hormone production. So the messages must get into the cell first, and FSH and LH are too large to get into the cellular structure. So, they have to activate a membrane-based enzyme called adenylate cyclase to produce cyclic AMP to enter the cellular network and start hormonal formation in the body. This is the P, or the production of hormones. So by thinking about cellular membrane health, if a doctor does an essential fatty acid analysis, the patients may be very low in omega-3s; therefore, their cell membranes are more rigid and affect the body’s hormonal process. When patients are not taking their omega-3s, it could cause the inflammatory cytokines to cause more joint pain issues when various factors affect the body internally. Since inflammation can be good or bad in the body, it can cause hormonal dysfunction when they attack healthy cellular structures. That will affect this hormonal production process.
Hormonal Production Process In The Body
Dr. Alex Jimenez, D.C., presents: Once made, estradiol goes directly into the blood and is not stored, but it’s bound to SHBG and albumin. And SHBG is changed by obesity and insulin associated with hypothyroidism. So when women are obese or hyperinsulinemic will have less SHBG or hypothyroidism to transport the estrogen to the cells. This tells the body that the hormones are no longer FSH or LH and cyclic AMP, but this is estrogen. And so, estradiol is sensitive since estradiol has to go in and have a cytoplasmic receptor. So the estrogen receptor is in the cytoplasm. After it binds to the receptor, it goes into the nucleus, and it’s transcribed and then goes back out and translated to allow the body to make proteins that cause cell proliferation. Estrogen is a proliferative hormone. And once it’s acted on the cell after proliferation, it’s degraded in the cell with heat shock proteins or released back into the circulation in the body’s system.
Let’s talk about some of the basics of biochemistry because the steroidogenic pathway n the body has different ways to reduce carbons in the body. The body’s system could convert it into estrone or estriol, with less estrogen in circulation. And then estradiol, estrone, estriol, everything is eliminated through the detoxification pathways. So in the Living Matrix, healthy detoxification and estrogen metabolism pathways help the body stay functional. When the body goes through detoxification, it helps reduce the issues by figuring out what is causing the problems affecting the body’s system and slowing introducing or taking away the pain that can allow normal hormonal regulation. When the body reduces excessive carbon, it can lower cholesterol from reaching dangerous levels.
Cholesterol & Hormones
Dr. Alex Jimenez, D.C., presents: So it all starts with cholesterol, and the body can’t make enough cholesterol, so we consume food to allow it to enter the body and begin to biotransform into LDL (low-density lipoprotein) to initiate steroid hormone synthesis. So we need LDL in the body to decrease the carbons since it is a union directional. When it comes to hormone deficiency cases, sometimes women can come in with extremely low LDLs because they’re on statins, underweight, or over-athletic; these are connections and pattern recognition. In a female’s body, the ovaries on the left and right side of the female reproduction system produce all three sex steroids: estrogens, progesterones, and androgens, for optimal body function. They are different than the male’s reproduction system, which includes the testicles, due to the other enzymes. They differ from the testes in many ways due to additional hormonal output in the body, which is different than adrenal hormones. For example, if the body can’t make aldosterone or cortisol in the endocrine glands, they will be shunted to make sex hormones. And since each body is diverse, male or female, some hormones can’t make glucocorticoids or mineral corticoids.
So we must think about mitochondrial health for hormone production, which is critical for producing hormones. For expecting mothers, it allows the formation of pregnancy alone in the mitochondria. So mitochondrial health energy is related to hormone health, which causes cholesterol uptake by the mitochondria in the adrenal glands and ovaries that can stimulate ACTH. So the mitochondria can make hormones as we go while enabling the enzymes in the female’s body to induce pregnenolone formation. However, getting the cholesterol to the inner membrane and LDL to the inner membrane to the mitochondria is the rate-limiting step in all steroid hormone synthesis. Now it can develop and go into two different pathways in the body. It can create DHEA, or it can include progesterone when cholesterol is forming pregnenolone and can look diagrammatically in test results.
DHEA & Hormones
Dr. Alex Jimenez, D.C., presents: So if the mitochondria can enable the body’s pregnenolone to form DHEA or progesterone, let’s start with going over things with developing progesterone since it’s hydroxylated. It creates an enzyme called 17 hydroxy progesterone, the immediate precursor of the androgens and estrogens. So the 17 hydroxy progesterone will eventually form androgens or estrogens, and androstenedione can develop testosterone, and both can become estrogens by aromatization. So what does this mean? It means you must be concerned about too many androgens being around because they can become estrogen. The best way to remember this is that androstenedione can become estrone, and testosterone can become estradiol. This can cause progesterone to be the precursor to cortisol in the body and can go in two different directions.
So progesterone is also the precursor to aldosterone, which asks what will happen when the body needs cortisol or aldosterone. The body will then produce less progesterone causing it to be shunned in hormonal production and causing cortisol to overproduce. This is known as cortisol steal, and if it is not treated at the moment, it can cause muscle and joint inflammation in the body, leading to various issues that the person is dealing with.
A decreased formation of androgens and estrogens can inhibit the DHEA pathway. So when the body makes more cortisol, it can cause the hormones to develop an estrogen-dominate shape causing the cortisol hormone to stimulate aromatase. To that point, it can lead to breast cancer, fibroids, and endometriosis in the long term. Women can get stress, hot flashes, and decreased libido due to that hormonal decrease in their bodies.
Conclusion
Other issues like stress can cause increased cortisol formation, anxiety, inflammation, simple carbohydrates, et cetera to the body associated with joint and muscle pain. They can also inhibit sex and sex hormone production directly and indirectly. So this is where people have to be concerned if they’re giving DHEA because DHEA can convert itself into sex hormones. So that can be a good thing if you’re dealing with hormonal deficiency. But if you give too much DHEA, you can overproduce hormonal function.
Dr. Alex Jimenez, D.C., presents how hormonal dysfunction can be assessed and treated through various therapies specializing in hormones and how to regulate them in this 3 part series. This presentation will provide valuable information to many people dealing with hormonal dysfunction and how to utilize different holistic methods to optimize their health and wellness. Part 2 will look at the assessment for hormonal dysfunction. Part 3 will look at various treatments available for hormonal dysfunction. We refer patients to certified providers incorporating various hormone therapies to ensure optimal health and wellness. We encourage and appreciate each patient by referring them to associated medical providers based on their diagnosis when it is appropriate. We understand that education is an excellent way when asking our providers intricated questions at the patient’s request and understanding. Dr. Alex Jimenez, D.C., only utilizes this information as an educational service. Disclaimer
What Are Hormones?
Dr. Alex Jimenez, D.C., presents: Today, we will look at utilizing foundational PTSD treatment strategy steps. As a treatment strategy, it is about the production, transportation, sensitivity, and detoxification of the hormone in PTSD. So let’s start with how interventions and major factors that influence these pathways within the access impact other body areas. How does an intervention on one hormone affect other hormones? So did you know that thyroid replacement can change the HPATG access in the body? So when people are dealing with hypothyroidism or subclinical hyperthyroidism and are being treated with suppressive thyroid hormone replacement, it induces changes in their bodies. This means they will become hypersensitive from ACTH to CRH or corticotropin-releasing hormone.
What this means is that they will produce and release more ACTH. When the patient becomes hypersensitive from an influx of hormones, it could lead to various issues with the other body systems that affect organ and muscle functionality. This is another reason patients feel great on even low doses of thyroid replacement; it stimulates the adrenals. Many patients tend to overrun their adrenals, and when they get treatment, they get a little hit to their adrenals when their doctors are helping their thyroid. So looking at the thyroid, we see the thyroid gland is producing t4, forming reverse T3 and t3. So when doctors look at the thyroid pharmacological doses of glucocorticoids, which is what they give for anti-inflammatory therapy to their patients, or if people have elevated glucocorticoids as in Cushing syndrome, what that does is it inhibit thyroid secretion because it reduces the TSH response to TRH, which makes less TSH. When there is less secretion in the thyroid can lead to overlapping issues associated with unnecessary weight gain, joint pain, and even metabolic syndrome.
To that point, stress inhibits the thyroid. In contrast, estrogens have the opposite effect, where they increase TSH secretion and the thyroid gland’s activity. So that’s a reason why women feel so much better on even low doses of estrogen replacement. So just like thyroid replacement in low amounts that bump the adrenals, if we’re giving low estrogen doses, it can bump up thyroid function. However, many doctors have to go slow when providing hormone treatments to patients because the additional hormones will affect the other hormones in the body. When it comes to hormone replacement therapy, it is important to learn how interventions within the communication node impact other nodes in the matrix. So, for example, let’s look at how the communication node affects the defense and repair node in the body. Research studies reveal HRT’s effects on inflammation markers and look at 271 women who used conjugated equine estrogen alone, who had a 121% increase in CRP after a year.
And if they used that in addition to synthetic progestin, they had a 150% increase in CRP after a year. So synthetic estrogen is not bioidentical; this is synthetic pregnant mare’s urine, and synthetic progestins are pro-inflammatory. What about the communication node and the assimilation node? This is an interesting study because many doctors are trying to help their patients and the future generation in society. So it’s important to know when the mother is stressed during pregnancy since that can change the baby’s microbiome. That means doctors have an opportunity to support early intervention in microbiome support. Knowing this is vital for prenatal stress based on questionnaires or elevated cortisol was strongly and persistently associated with infants’ microbiome and colonization patterns.
So we’re also here to learn how interventions on the matrix affect the hormone node or the communication node. So as an example, we’ll look at what happens in the assimilation node involving the communication node, as this affects antibiotics on the intestinal metabolome. Everyone knows about antibiotics’ impact on the microbiome, but a metabolome is a change in the metabolic function of a particular organ, the intestine. To that point, when there are so many metabolic pathways that antibiotics affect, the metabolism of steroid hormones was the most profoundly impacted. So eight metabolites that are part of this hormone pathway, which gives us PTSD, were increased in feces after antibiotic treatment. Then we have another way that the gut affects hormones, and this is looking at metabolic endotoxemia. Many doctors learn about metabolic endotoxemia in AFMCP, which mentions leaky gut or increased intestinal permeability. When many individuals are dealing with gut issues affecting their well-being, like problems in their joints or muscles causing them pain, we provide various solutions and develop a treatment plan with our associated providers based on the diagnosis.
Endotoxins Affecting Hormones
Dr. Alex Jimenez, D.C., presents: Endotoxins or lipopolysaccharides are from the cell membranes of bacteria. So bacterial endotoxins are translocated from the gut lumen because of increased intestinal permeability. So with that increased permeability, those endotoxins are translocated, which starts an inflammatory cascade. When endotoxins cause GI issues, the inflammatory markers can affect the upper and lower portions of the body and the gut-brain axis. When the gut-brain axis is affected by inflammation, it could lead to joint and muscle pain associated with somato-visceral and visceral-somatic problems. To that point, the inflammatory cascade from the leaky gut affects the ovary, reduces progesterone production, and contributes to luteal phase deficiency. That’s incredibly important for doctors to take care of patients that are there to optimize fertility. It is especially important for patients to let their doctors know when they have excess estrogen and that they are producing as much progesterone as possible. So we must worry about gut permeability in ovulation, luteal phase deficiency, and estrogen-progesterone imbalance. What about the biotransformation node? How does that affect the communication node? In preschool children, phthalates and thyroid function have an inverse association between the metabolites or the amount of folate and thyroid function in the system measured in children at age three. When inflammatory issues affect thyroid function in children, it can affect cognitive outcomes, thus reducing phthalates production in the thyroid, leading to mental problems.
How do mental, emotional, and spiritual considerations contribute to the communication node? We want to start with the bottom of the matrix like we always do, which involves functional medicine. Functional medicine provides holistic approaches to identifying the root problem affecting the body and developing a personalized treatment plan for the patient. By looking at the lifestyle factors at the bottom of the Living Matrix, we can see how hormone dysfunction affects the communication nodes in the body. A recent paper found that there was a positive relationship between menopausal symptoms and social support and that menopausal symptom decrease as social support increases. Now let’s talk about how stress impacts HPA access. By looking at how stimulation from the sex hormone-producing parts of the body or the goads, the thyroid access, the adrenals, and the sympathetic nervous system (fight or flight) can add up all the stressors affecting us, called allostatic load.
And allostasis refers to our ability to respond to those stressors through stress-coping mechanisms. Many patients are asking us for guidance. They’re asking how they can frame their personal experiences and stressors. Still, they’re also asking how they prepare the societal events in a larger context, And many of us as functional medicine practitioners are seeking the same thing. And so, we’re going to show you in detail what stress does to the body and how to find ways of decreasing anxiety or stress in the body to prevent future issues in the organs, muscles, and joints.
How Stress Inhibits Estrogen
Dr. Alex Jimenez, D.C., presents: Does stress creates adrenal stress, and does it affect our fight or flight primary response hormone (adrenaline)? Stress can cause the sympathetic nervous system to increase blood pressure, respiration, heart rate, and general alertness while redirecting our blood to increase our adrenaline. So when you are in a situation, your adrenaline can cause you to fight or run, which causes your muscles to get blood, which decreases blood to your core or your non-essential organs. So the functional medicine model would identify various triggers or mediators, whether acute or chronic, that can act as an instigator of hormone dysfunction that can create overlapping issues that can disrupt adrenal function in the thyroid.
So, looking at these responses can help us see the physical problems that are happening if adrenaline is chronically increased over the long term, leading to anxiety, digestion problems, et cetera. Now cortisol is our vigilance hormone that helps maintain the emergency response to back up or support the adrenaline. An example would be a fire truck or police that come in after the immediate first responder. So cortisol facilitates the quick adrenaline response to keep the body going as needed. And it has many other roles as well. It helps with increased blood sugar and causes fat storage. So when people come in with weight around the middle and dealing with overlapping issues in their body, think of cortisol since it’s anti-inflammatory and regulates the nervous system. Cortisol can be both good and bad for the body, especially when an individual is dealing with stressful events affecting their health and causing issues affecting their mobility.
So now, let’s talk about how stress impacts the entire body and the immune system. Stress can increase susceptibility to infections, increasing their severity in the body. So here we see stress affecting the defense and repair node, leading to immune dysfunction and stress-induced immune dysfunction. An example would be if a person is dealing with a disorder that affects their gut, like SIBO or leaky gut; it can increase the production of pro-inflammatory cytokines and causes joint and muscle pain to the lower back, the hips, the knees, and overall wellness. When the pro-inflammatory cytokines affect the gut system, they can also cause thyroid dysfunction, disrupting hormone production.
So if someone’s taking that hormone replacement therapy (HRT), it can increase their inflammation, especially if they are stressed. So, as functional medicine practitioners, we’re always thinking and looking for pattern recognition as we start thinking about things differently from conventional methods regarding health and wellness.
What is it when you see a person dealing with chronic stress, and what is their response? They will usually answer, “I sweat a lot; I get nervous and anxious just remembering what has happened to me. I’m afraid of experiencing that ever again. Sometimes these pathways give me nightmares. Whenever I hear a loud noise, I think of carbon rings and get nauseous.” These are some tell-tale signs of someone dealing with chronic stress associated with PTSD, which can affect the hormone levels in the body. Many functional medicine providers can utilize available treatment regarding hormonal dysfunction in PTSD. So the general strategy for treating hormone dysfunction is the production, transport sensitivity, and detoxification of hormones in the body. Remember that when you have someone dealing with hormonal issues, it is best to devise a strategy to deal with this issue.
So what can we do to affect how hormones are produced or have been over-produced in the body? We want to look at how hormones are made, how they may be secreted within the body, and how they’re transported. Because what if they’re transported in a way that the transport molecule is low in concentration, allowing them to be free hormones? So that’s the interaction with other hormone sensitivity, and how do we change or look at cellular sensitivity to the hormonal signal? For example, progesterone affects estrogen receptors which cause detoxification or excretion of the hormone.
So before we think about giving or replacing a hormone, we ask what we can do to affect that hormone in the body. Specifically, how can we influence the hormone’s production, transport, sensitivity, detoxification, or elimination? So when it comes to hormone production, what are the building blocks for thyroid hormones and cortisol? So if we’re low on thyroid hormones, we want to ensure that we have the building blocks of serotonin. So what affects synthesis? If a gland is inflamed with autoimmune thyroiditis, it may not be able to make enough thyroid hormone. And that’s why people with autoimmune thyroiditis have low thyroid function. What about hormone transportation? Do the levels of one hormone in the body impact the levels of another? Estrogen and progesterone are often in a dance in the body. So does a hormone transport from the origin glands to the target tissue, which can impact its effectiveness?
If there is an overproduction of hormones attached to the transport protein, there won’t be enough free hormone, and there can be hormone deficiency symptoms. Or it can be the opposite if there needs to be more transport protein, then there will be too many free hormone molecules and hormone excess symptoms. Therefore, we want to know if we can impact the free hormone level and see if it is transformed. So we know that T4 becomes the active form of T3 or a thyroid inhibitor, reverse t3, and can we modulate those pathways? What about sensitivity? Are nutritional or dietary factors influencing the cellular response to cortisol, thyroid hormones, testosterone, estrogen, et cetera? With many cell membrane binding proteins, the cell membrane is involved in hormone metabolism. And if the cell membranes are rigid, insulin, for example, has a hard time getting in it now as we look into hormone detoxification. How do we alter the metabolism of estrogens or testosterone?
And what can we do to affect estrogen’s binding and excretion? So, can estrogen have to be eliminated healthily? And that depends on whether there’s hydroxylation on a particular carbon, but it also has to be excreted in terms of total amounts. So constipation, for example, will decrease the quantity of estrogen excreted. So we use the vault as a metaphor and the theme, as we said, is to treat the matrix first before directly addressing hormone dysfunction.
Cortisol Affecting The Communication Nodes
Dr. Alex Jimenez, D.C., presents: In the Living Matrix, we have to unlock or treat all the nodes to open the vault to get inside and address hormones. This is because the endocrine system is so complex it often self-corrects when other imbalances are addressed. And remember, hormonal imbalance is often an appropriate response by the body to imbalances elsewhere. That’s why treating other imbalances often addresses the hormonal issue. And also, remember hormones like picograms are in very low concentrations. So it’s very hard to be precise when we give patients hormones and allow the body to auto-correct. That’s why we say to treat the matrix first. And when we get inside the communication node in the body, we look at the center of the matrix and discover the body’s emotional, mental, and spiritual functions to help normalize hormones. And while these are addressed, how can we fix the hormonal communication nodes?
When inside the communication node, the treatment must follow an order: adrenal, thyroid, and sex steroids. So these are important concepts to remember, treat adrenals, thyroid, and finally, sex steroids. And the way we depict the pathways will be consistent. So here you see the standard representation we will use for the steroidogenic path. And you see all of the different hormones here. The enzymes in the steroidogenic pathway are color-coded, so many doctors can know which enzyme affects which step. Next, we will look at the modulation of the steroid pathways through lifestyle, like exercise, and how stress affects aromatase, making estrogen.
Now, as we get into the real, heavy part here about the steroid pathways, we inform many of our patients to take a deep breath as it shows that taking a deep breath can increase a person’s cognition and provide the ability to understand everything. So the big picture here is everything starts with cholesterol and how it affects the hormones in the body. So cholesterol forms the mineral corticoid aldosterone, which then develops cortisol, ultimately creating androgens and estrogens. When patients are given consultation on what is going on with their bodies, many don’t realize that high cholesterol could potentially lead to chronic stress, which is associated with cardiovascular issues that can ultimately invoke visceral-somatic disorders.
Dr. Alex Jimenez, D.C., presents: When a female patient is dealing with fibroids or endometriosis, many doctors devise a treatment plan with other medical providers to reduce the formation of the estrogen hormones by inhibiting and modulating the aromatase enzymes. This allows the patient to make small changes to their lifestyle habits by ensuring their zinc levels are normal, not drinking alcoholic beverages constantly, finding ways to reduce their stress levels, and normalizing their insulin intake. Each treatment plan caters to the individual as they find ways to reduce their cortisol levels and regulate healthy hormone production. This will allow the body to increase estrogen production while decreasing the aromatase. So when we are discussing stress, it can negatively impact the hormone pathways directly by increasing cortisol, thus causing the pituitary glands to increase the CTH when stress is responding to the body. Many individuals are dealing with chronic stress in their bodies, which can cause overlapping risk profiles to the musculoskeletal system, causing muscle and joint pain.
So the pituitary system produces cortisol when the body calls for it directly when the individual is dealing with acute stress. However, chronic stress can indirectly increase cortisol levels; it causes the enzyme 1720 lyase to be inhibited in the body, causing a decrease in anabolism, thus slowing down the body’s energy levels. So stress inhibits this enzyme. So when stress inhibits the 1720 lyase enzyme in the body, it can cause the pituitary system to produce more cortisol and cause more issues like joint to affect the individual. So those are the two ways that stress leads to more cortisol directly through ACTH and indirectly by inhibiting 1720 lyase.
Inflammation is important in the body as it also has a two-way path, as it can impact these pathways the same way stress does. Inflammation can inhibit the 1720 lyase enzyme, causing the body to be pro-inflammatory and can stimulate aromatase. Like stress, when the body is dealing with inflammation, the pro-inflammatory cytokines stimulate aromatase enzymes to cause an increase in estrogen formation. When this happens, it allows the doctors to notice why their patients are overly stressed and have inflammatory markers in their gut, muscles, and joints. To that point, inflammation can also increase an enzyme called 5alpha reductase. Now, 5alpha reductase causes the formation of a hormone called dihydrotestosterone (the active form of testosterone in the body cells other than the muscles, causing hair loss. So insulin, stress, and inflammation contribute to hair loss because insulin has the same effect. Insulin or blood sugar gives the body energy to move throughout the day. When individuals have too much or too little insulin in the body, it can lead to insulin resistance, correlating to metabolic syndrome associated with hair loss.
Holistic Methods For Hormones
Dr. Alex Jimenez, D.C., presents: How do insulin, cortisol, and inflammation play their part in the thyroid? Well, all of these hormones help make the body functional. When the thyroid has an underlying condition like hypo or hyperthyroidism, it can cause the body to over or underproduce hormones to regulate healthy normal body functions. So this forward feed cycle can cause the individual to have various issues affecting their body due to hormonal dysfunction. This combination of insulin resistance, high insulin, weight gain, and stress affects many patients, causing metabolic syndrome. To normalize hormonal function, we must look at all these factors driving hormonal dysfunction in patients.
When going for hormonal treatment, it is important to know about the different nutraceuticals and botanicals because before, it was called a lifestyle change back in the day. In a health clinic, specific neutraceuticals and botanicals can affect estrogen formation through the enzyme aromatase. However, various factors like diseases, medications, toxins, and elevated insulin can also increase aromatase enzymes, leading to more estrogen in the body. And then diseases, medications, and toxins do the same thing. A research study reveals that when men and women interact, the men’s cognitive performance declines, followed up with a mix-sex encounter. This can change how hormone function in the body when there are changes in formal function that can affect the central nervous system’s cognitive function in the body.
When middle age patients get examined by their doctors, the results can show if they have elevated insulin, an increase in stress and if there is inflammation in their bodies. This allows the doctors to work with associated specialists to develop a treatment plan that caters to the patient to begin small changes in their health and wellness journey.
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