Hormone Balance. Hormones like estrogen, testosterone, adrenaline, and insulin are vital chemical messengers that affect many aspects of one’s health. Hormones are secreted by various glands and organs, including the thyroid, adrenals, pituitary, ovaries, testicles, and pancreas. The entire endocrine system works together to control the level of hormones circulating throughout the body. And if one or more is imbalanced, it can cause major health problems.
The most common symptoms of hormone imbalance include:
Infertility and irregular periods
Weight gain or weight loss (unexplained, not due to intentional changes in one’s diet)
Depression and anxiety
Fatigue
Insomnia
Low libido
Appetite changes
Issues with digestion
Hair thinning and loss
Symptoms of hormonal imbalances can range depending on what type of disorder or illness they cause. For example, symptoms of diabetes include weight gain, appetite changes, nerve damage, and eyesight problems. Conventional treatments for hormone imbalances include synthetic hormone replacement therapies, i.e., insulin injections, thyroid medications.
However, with these types of treatments comes negative effects, such as medication dependency, serious side effects like stroke, osteoporosis, anxiety, reproductive problems, cancer, and more. And with these synthetic treatments, the symptoms aren’t treated but only masked.
Fortunately, there are ways to acquire hormone balance naturally. For example, stay away from oils high in omega-6 fats (safflower, sunflower, corn, canola, soybean, and peanut). Instead, utilize rich sources of natural omega-3’s (wild fish, flaxseed, chia seeds, walnuts, and grass-fed animal products).
If you are experiencing any of these situations, then you might be going through perimenopause.
When the body hits a certain age, the hormone levels will naturally increase then decrease, causing the person to experience symptoms that they never have. For women, they go through an aging progression known as menopause, which is a normal part of aging, and when the female stops producing eggs. Menopause occurs when a female is in her late forties to her early fifties, depending on which country they are from. Before a woman goes through the menopausal process, perimenopausal begins before the actual menopausal progression occurs. Not only that but when a woman goes through perimenopause, their endocrine system is being affected with hormonal changes as the hormones begin to fluctuate during the menopausal shift.
Perimenopausal
Perimenopausal can be defined in various ways; however, researchers can agree that perimenopausal begins when a woman starts to have irregular menstrual cycles. This is due to a natural decline in their ovarian function, and it will be their last menstrual period. Research shows that perimenopausal leads up to menopause and follows after post-menopause. Surprisingly though, during perimenopausal years, the hormone levels will begin to fluctuate, and the estrogen levels begin to become a bit higher than average. Afterward, though once menopause goes through the postmenopausal stage, the hormone levels will begin to decrease gradually naturally.
Perimenopausal Symptoms
When it comes to the endocrine system, it plays a role when a female is going through perimenopause. Since the endocrine system produces hormones and is responsible for reproduction hormones, it makes sure that the female body has the two hormones estrogen and progesterone. When there is a lack of hormones in the female body, it is due to the effects of hot flashes that are caused by perimenopause. Now research shows that most women do not expect that to have hot flashes until they have menopause. It is one of the symptoms that all females get. Other symptoms can cause women to have them when they are going through. They are:
Hot flashes and night sweats: There is about an estimated 35%-50% of women who have perimenopausal, will suffer a sudden wave of body heat that is consist of sweating ant flushing that can last about five to ten minutes. Surprisingly it can happen at night as well when the body starts to sweat.
Vaginal dryness: When estrogen levels began to decline during late perimenopause naturally, it can cause the vaginal tissue to become a bit thinner and drier. When this happens, it can cause irritation, itching, and can be a source of pain during intercourse.
Uterine bleeding: When the progesterone levels start to decline, it can cause the growth of the endometrium, which is the uterine lining to become a bit thinker than usual before it sheds, thus resulting in a very heavy period. Not only that, but if a female has fibroids or endometriosis, then those two conditions may become a bit more troublesome.
Sleep problems: Studies found out that about forty percent of perimenopausal women have trouble sleeping. Between the night sweats and the disrupted sleep patterns, the problem can be a little complex to be blamed on the hormone oscillation, and the sleep cycles change as a person ages. Plus, insomnia is a common complaint for both sexes.
Mood swings: There is about ten to twenty percent of women who have experienced mood swings during perimenopause that has been linked to low estrogen levels. When women have experienced mood swings, it usually happens around midlife, like stress, poor overall health, and a history of depression.
Short term memory: Surprisingly, many women have complained about having short term memory problems as well as having a difficult time concentrating during the menopausal transition. Even though estrogen and progesterone help maintain brain function, there is too little information to separate the effects of aging and the psychosocial factors that can be related to hormone changes.
Studies have even found out that during the menopausal transition, the regular patterns of a female’s menstrual cycle will become disrupted, and the normal ovulatory cycle will decline naturally. At the same time, the gonadotropin levels will start to rise as well as the follicle-stimulating hormones will increase on a woman’s feature.
Conclusion
Menopause is a natural stage in a woman’s life. The hormone levels will begin to fluctuate, and it all starts when a woman’s menstrual cycle begins to stop. With perimenopause, it is the beginning of the menopausal transition as the female body starts to change. From hot flashes to irregular sleep patterns, perimenopause is a natural way to let the body know that change is coming. Some products are designed to help support the estrogen metabolism in both the female and male bodies as well as products to help support the hormonal balance and the normal menstruation for females in the reproductive age.
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.
References:
Publishing, Harvard Health. �Perimenopause: Rocky Road to Menopause.� Harvard Health, June 2009, www.health.harvard.edu/womens-health/perimenopause-rocky-road-to-menopause.
Buckler, Helen. �The Menopause Transition: Endocrine Changes and Clinical Symptoms.� The Journal of the British Menopause Society, U.S. National Library of Medicine, June 2005, www.ncbi.nlm.nih.gov/pubmed/15970017.
Cherney, Kristeen. � Effects of Menopause on the Body.� Healthline, 5 Feb. 2019, www.healthline.com/health/menopause/hrt-effects-on-body.
Edwards, Beatrice J, and Jin Li. �Endocrinology of Menopause.� Periodontology 2000, U.S. National Library of Medicine, Feb. 2013, www.ncbi.nlm.nih.gov/pubmed/23240949.
Wexler, Tamara L. �Perimenopause and Menopause Overview.� EndocrineWeb, 25 Mar. 2016, www.endocrineweb.com/conditions/menopause/perimenopause-menopause-overview.
The University offers a wide variety of medical professions for functional and integrative medicine. Their goal is to inform individuals who want to make a difference in the functional medical fields with knowledgeable information that they can provide.
Shaky, jittery, or have tremors throughout your body?
If you are experiencing any of these situations, then it might be your blood-brain barrier and your endocrine system that may be imbalanced.
The brain in the human body is the primary control system that makes sure that each of the body’s system is working correctly. This includes the gastrointestinal system, the hepatic system, the neurological system, and, most importantly, the endocrine system. In the brain, however, there is a tissue known as the blood-brain barrier, it is connected to the endocrine system. It is essential to make sure that the blood-brain barrier and the endocrine system are healthy in the human body.
The Blood-Brain Barrier
The blood-brain barrier in the body separates the central nervous system from peripheral tissue. Even though the blood-brain barrier separates the nervous system, it does not prevent hormones from entering the brain. Research shows that the brain can bind and secretes any circulating substances and can be qualified as an endocrine organ. When this happens, it can be one of the largest and most metabolically active of the endocrine organs by acting as both the target and secretor of hormones.
With the blood-brain barrier, it conveys the blood vessels by transporting the blood from the heart to every tissue and organs throughout the body. It then delivers oxygen and the nutrients to all the tissues and removing the carbon dioxide and metabolic waste from the tissues. The blood vessels also convey hormonal signals to the tissues and is a mediator for interacting with the peripheral immune system with each tissue. Research shows that since the blood-brain barrier is an endocrine tissue, the substances that are being carried in the blood can emerge in a hormone-like fashion. The research stated that the blood-brain barrier could exhibit the endocrine system properties as well as being a target for hormones that can affect many of the blood-brain functions in the body.
The Endocrine System
The endocrine system is a collection of glands that secretes out and produces hormones that can regulate not only the body but makes sure that it regulates the body’s metabolism and many other functions that the body needs to function correctly. When the body’s hormone levels fluctuate, it can be very good or horrible, depending on the situation. If the body produces an abundance of hormones, it can cause a person to have hyperthyroidism, and when the body produces a low abundance of hormones, the body can have complications and cause the body to develop chronic illnesses. Stress, infections, and diabetes can influence the body’s hormone levels by making hormones either too much or too little. By making sure that the body’s hormones are at a balanced level is essential because eating right and doing daily exercises can make the body function properly and feel good as well.
Since the body can produce hormones naturally, the job of the primary hormone is to make sure that it is traveling in the bloodstream and making it to the various organs and tissues that need the hormone levels. The hormone levels can tell every organ and tissues what to do and how to function. When the hormone levels get crazy by being produced too much or too little, it causes those organs and tissues to malfunction.
For the blood-brain barrier, since it is an endocrine tissue, it can divide the hormone receptors. The research found out that the blood-brain barrier can respond to circulate the hormone substances and secrete those hormone substances into the blood circulation and the central nervous system. It can also make sure that when the hormone receptors are being divided that it goes to the central nervous tissues and the peripheral tissues. The research also found out that insulin levels can also affect the brain’s endothelial cell function through several parameters and modulating amino acids, leptin, and p-glycoprotein transporters in the body.
Surprisingly there is a unique feature that the blood-brain barrier possesses. The blood-brain relies on its cell membrane surfaces facing into the bloodstream and the interstitial fluid of the central nervous system so that way it can receive signals for the body. The research found out that the blood-brain barrier’s properties are primarily manifested within the brain’s endothelial cells. They can be induced and maintained through critical interactions with the cells that are interacting in the neurovascular unit in the brain. With these endocrine-like mechanisms that the blood-brain barrier has, it can help dampen the effects of endocrine diseases like neurodegenerative conditions and Alzheimer’s disease.
Conclusion
The blood-brain barrier is an essential tissue in the brain as it functions as an endocrine tissue and does play a role by interacting with the hormone levels that the endocrine system secreted out to the body. When the hormone levels start to malfunction by either producing an abundance or too little amount of hormones, it can cause the body to have chronic illnesses and the blood-brain barrier to dysfunction in the brain, causing degenerative neurological disorders in the brain as well. Some products can help the endocrine system by making sure the hormone levels are balanced as well as products for a healthy brain function for a healthy body.
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.
References:
Banks, William A. �Brain Meets Body: the Blood-Brain Barrier as an Endocrine Interface.� Endocrinology, Endocrine Society, Sept. 2012, www.ncbi.nlm.nih.gov/pmc/articles/PMC3423627/.
Banks, William A. �The Blood-Brain Barrier as an Endocrine Tissue.� Nature Reviews. Endocrinology, U.S. National Library of Medicine, Aug. 2019, www.ncbi.nlm.nih.gov/pubmed/31127254.
Daneman, Richard, and Alexandre Prat. �The Blood-Brain Barrier.� Cold Spring Harbor Perspectives in Biology, Cold Spring Harbor Laboratory Press, 5 Jan. 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC4292164/.
Zimmermann, Kim Ann. �Endocrine System: Facts, Functions and Diseases.� LiveScience, Purch, 18 Feb. 2018, www.livescience.com/26496-endocrine-system.html.
The University offers a wide variety of medical professions for functional and integrative medicine. Their goal is to inform individuals who want to make a difference in the functional medical fields with knowledgeable information that they can provide.
If you are feeling or experiencing any of these situations, then you might be experiencing male menopause or andropause.
When men and women are heading to their 50s, their bodies start to change. For women, they start to develop hot flashes, and their hormones start to change as well. Since it is normal for hormones to change naturally when a person is aging, it affects women more than men. Studies have shown that sex hormones in males occur gradually as they age. There is a term called “male menopause,” and it is defined when males have a decreased level of testosterone that is related to aging. Many healthcare professionals have another name for “male menopause,” and that is andropause.
Andropause
Andropause and menopause are entirely different since menopause causes a woman’s ovulation and hormones to plummet for a short period. With andropause, it causes a male’s testosterone production and their other hormones to decline for many years. Since testosterone levels in males are vastly different, older men tend to have lower levels than younger men, and testosterone levels can gradually decline throughout adult life.
Studies found that when a person ages, their aging process can affect the body�s systems, including the endocrine system. When a person is aging, their adrenal glands will go through morphological changes, and those changes can alter their cortex endocrine functions. Another study showed that since andropause is age-related, there is a partial insufficiency in the adrenal cortex in the endocrine system, and there are low levels of DHEA (dehydroepiandrosterone) and DHEA sulfate that can affect the cortisol levels.
DHEA and DHEA Sulfate
With DHEA and DHEA sulfate, research has found that these two are steroids that are produced abundantly by the adrenal glands in the endocrine system.� With these two components, they provide beneficial properties and effects that have anti-aging properties to stimulate the immune system and the endocrine system. When males are going through the changes as they get older, their hormones will naturally decrease in their bodies.
Since andropause is age-related and has partial insufficiency on the adrenal cortex and it is characterized by low blood levels of DHEA and DHEA sulfate when it is under the presence of cortisol levels in the body. With andropause and its characteristics, it shows how males have low DHEA levels, and it can cause them to have a higher risk of erectile dysfunction in their bodies. It is essential to know that the endocrine system initiates the aging process.
Andropause Factors
Some studies show how there are changes in the endocrine pathways and are being accompanied by healthy aging. The changes can be from growth hormones to sex hormones in the male�s bodies. The results show a clinical significance of these changes and have the results morphologically and functionally. Surprisingly there have been many age-associated diseases like epithelial skin cancer and neurodegenerative diseases that can attack the body due to the lack of hormones that are being produced. Hence hormone replacement therapies are conducted for older individuals.
When it comes to andropause and low testosterone in males, there are recognizable signs and symptoms that healthcare professionals and male individuals should look for. They can be:
Sexual function: Low testosterone level can reduce sexual desire, causes erectile dysfunction and infertility, to name a few. Even male’s testes might be smaller as well.
Sleep patterns: Sleep disturbances like insomnia or feeling more tired is due to low testosterone in the body.
Physical changes: For males who have low testosterone, various physical changes can happen to their bodies. They can either have increased body fat, reduced muscle bulk, and decrease bone density. Sometimes the male body can develop gynecomastia (swollen breast) and body hair loss.
Emotional changes: With low testosterone levels, they can make males have a decrease in motivation or self-confidence.
It is essential to know that when males have low testosterone, they can go for testosterone therapy to help dampen the signs and symptoms that they might experience.
Conclusion
Andropause is when males have low testosterone levels in their bodies. Naturally, hormone levels can decrease when males get older, and it is essential to know that there is testosterone therapy for males who have low levels of this hormone. It is ok to be on a healthy lifestyle and eating natural foods that can help boost up hormone levels in the body to make sure that it is functioning correctly. Some products are here to help the endocrine system and support the metabolic system as well. They even help the adrenal glands and support the gastrointestinal system to make sure the body is functioning correctly for a healthy new year.
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.
References:
Makrantonaki, Evgenia, et al. �Skin and Brain Age Together: The Role of Hormones in the Ageing Process.� Experimental Gerontology, U.S. National Library of Medicine, Oct. 2010, www.ncbi.nlm.nih.gov/pubmed/20719245.
Nawata, Hajime, et al. �Adrenopause.� Hormone Research, U.S. National Library of Medicine, 2004, www.ncbi.nlm.nih.gov/pubmed/15539809.
Papierska, Lucyna. �Adrenopause – Does It Really Exist?� Przeglad Menopauzalny = Menopause Review, Termedia Publishing House, June 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5509973/.
R�mmler, Alexander. �Adrenopause and Dehydroepiandrosterone: Pharmacological Therapy versus Replacement Therapy.� Gynakologisch-Geburtshilfliche Rundschau, U.S. National Library of Medicine, Apr. 2003, www.ncbi.nlm.nih.gov/pubmed/12649580.
Staff, Mayo Clinic. �Understanding Aging and Testosterone.� Mayo Clinic, Mayo Foundation for Medical Education and Research, 18 May 2017, www.mayoclinic.org/healthy-lifestyle/mens-health/in-depth/male-menopause/art-20048056.
By informing individuals about how the National University of Health Sciences provides knowledge for future generations who want to make a difference in the world. The University offers a wide variety of medical professions for functional and integrative medicine.
If you are experiencing any of these situations, then your mind-body connection might be unbalanced.
Throughout history, there have been studies and theories that the mind and body are separate. This theory has been accepted by many; however, there is so much evidence showing the mind, and the body having a bidirectional relationship in the body like the gut system that sends signals to the brain and vise versa. Since each organ sends its signals to the brain, the endocrine system sends out signals to the brain in the form of hormones, which can alter the person’s perception of the world through their eyes.
With that in mind, neuroplasticity has shown people that when they are in their environment, it can be altered the physical make up of the environment. Many modern scientists have acquired very sophisticated tools that can monitor the body’s brainwaves, the microbes, and many other factors that can change the body’s mind. Since stress is a full-body response, it can be both a good thing and a bad thing for the body. Good stress in the body gives the “fight or flight” response while the bad stress can become chronic and can lead the body to be dysfunctional. So the idea of having the mind and the body being a separate function seems to be a bit outdated but also informational.
By exploring the science and psychology of the mind-body disconnect, researchers can see how a person�s hormones can affect their perception of the world. By diving into the body, researchers can also see how stress can produce any visible changes in the brain as well.
How Experiences Alters the Mind
Many experiences can alter the mind. Whether it be good experiences that can be used in the work atmosphere or it can be bad experiences like being traumatized from horrible events. Studies show that trauma can alter the mind and depend on the situation. Even though the damage that is caused by trauma can be healed if it is minor. In some cases, it can scar a person even though the physical damage is healed. The mental damage is affected as a person can relive the traumatic experience that they encountered.
With good experience, they can be useful to a person if the damage has minored. If a person accidentally hurt themselves from any activities, they know not to do that again. Although if a person practices on specific activities and get better at it with time, it becomes a skill they can use. Sometimes a person can have a set of specific skills that are beneficial when they are working in the job they are in. So depending on the experiences that a person is dealing with, it can be either good or bad, but their brains will remember it.
The Difference Between Dualism and Monism
There has always been a philosophical debate on the mind and body. There are different ways to look at the mind-body connection, as many researchers have debated whether the mind is part of the body or that the body is part of the mind. Thus the difference between Dualism and Monism has different views on the mind-body connection.
Dualism is defined as being born out of the body as a physical object, and the mind or the consciousness is being constructed. The origins of dualism started with the Cartesian ways of thinking, where people started to argue that there was a two-way relationship between the mental and physical substances in the body. Surprisingly, the belief of the physical and mental systems are compartmentalized and not inter-related like what some people think.
French philosopher Ren� Descartes stated that the mind interacts with the body through the pineal glands and that the mind controls the body. He also summed his thoughts with one of his famous statements: �I think therefore I am.� With this statement, it tells researchers that the mind is a nonphysical and non-spatial substance that is being identified with consciousness and self-awareness in the body.
With monism, it is defined as a material point of view and that all humans are just merely complex physiological organisms. There is another type of monism known as phenomenalism. It also goes by subject idealism, and the concept of this monism is that the mind and the body are two separate entities. With each type of monism, the concepts always seem to be the same, which shows that each type of monism seems to ignore either the mind or the body. It is always one or the other, never together at the same time.
How Stress Hormones Influences the Brain
When it comes to stress and hormones, there has been a lot of scientific advancements on how the stress hormone affects the brain in the body. Since hormones have been found to alter the hippocampal neurons with stress hormones, they can give the body the burst of energy that it needs. Although, if there is a long-term activation of the stress hormone can wear the brain down and kill the brain’s cells. If someone has any psychological disorders that cause prolonged stress, it can impair cognitive function, and the results can be enhanced emotionally.
Conclusion
With the mind-body connection, they can send signals to each other and make sure that the human body is functioning correctly. When there is prolonged stress in the body, it can disrupt the signals and cause the body to dysfunction. The next article will be discussing how stress can rewire the brain in the body. Some products can help the body by supporting the endocrine system as well as helping the body to relieve temporary stress.
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.
References:
Perry, Bruce D., et al. �Childhood Trauma, the Neurobiology of Adaptation, and �Use?Dependent� Development of the Brain: How �States� Become �Traits.�� Semantic Scholar, 1 Jan. 1995, www.semanticscholar.org/paper/Childhood-trauma%2C-the-neurobiology-of-adaptation%2C-Perry-Pollard/1d6ef0f4601a9f437910deaabc09fd2ce2e2d31e.
Team, Biotics Education. �Stress – The Mind-Body Connection Part 1.� Biotics Research Blog, 9 Dec. 2019, blog.bioticsresearch.com/stress-the-mind-body-connection-part-1.
Woolley, C S, and P A Schwartzkroin. �Hormonal Effects on the Brain.� Epilepsia, U.S. National Library of Medicine, 1998, www.ncbi.nlm.nih.gov/pubmed/9915614.
If you are experiencing any of these situations, then your hippocampus might be lowered than usual.
The Hippocampus
In the brain, there is an S-shaped structured located in the inner folds in the temporal lobe called the hippocampus. The hippocampus is a complex brain structure that has a layer of densely packed neurons, and its primary function involves how humans learn and how their memory works. The hippocampus is part of the limbic system as well since it works the feeling and reacting function in the body. The limbic system is situated at the edge of the cortex and includes the hypothalamus and the amygdala.
These structures help controls the body�s different functions like the endocrine system and the �fight or flight� reaction response. With the hippocampus helping humans process what information they are learning, this structure can retrieve two kinds of memories that are important; they are declarative memories and spatial relationship memories.
Declarative memories: These are memories that are related to facts and events a person experience. It includes examples like how to memorize speeches or line in a play that a person is doing.
Spatial relationship memories: These memories involve pathways or routes that a person must learn. An example of this is transportation drivers like cab drivers, bus drivers, and truckers who have to learn the routes in the places they are going to. So they use spatial memory and practice their routes many times until they have it in their memories. The spatial relationship memories are stored on the right side of the hippocampus.
Sadly though, the hippocampus can be damaged by neurological diseases like Alzheimer�s disease and PTSD (Post-Traumatic Stress Disorder). When it is damaged, a variety of conditions can affect the hippocampus�s ability to do its job for the brain, thus making the individual suffer from retaining information.
Hippocampus Conditions
Several conditions can cause problems to the body when the hippocampus is damaged. This is known as hippocampus atrophy, where the neurons and neuronal volume in the hippocampal that is a loss.
Alzheimer�s Disease
Alzheimer�s disease is when an individual begins to lose their memory. When the hippocampus is damaged, it can cause a dissociation between the cortexes and leads to information registration failure. Studies show that when Alzheimer�s disease is progressing, the hippocampus will lose its volume, and it will become harder for an individual to function in their daily lives.
Epilepsy
When a person has epilepsy, it might be due to a damaged hippocampus. Research shows that around 50 to 75% of patients with this disease may have hippocampal sclerosis, and in case they have died, they have medial temporal lobe epilepsy. More research states that the mechanics of hippocampal sclerosis in epilepsy can be related to the development of inflammation on the uncontrolled local hippocampus and blood-brain barrier damage.
Hypertension
When the hippocampus is damaged, hypertension can happen to a person. Hypertension is another name for high blood pressure, and it can lead to severe health complications to the body. Even though the causes of hypertension are still unknown, the risk factors from hypertension can include:
Environmental factors like stress or a lack of exercise
Hormone activity
Blood plasma
Studies show that hypertension and other risk factors are being increasingly viewed as a putative factor that is leading to hippocampal atrophy.
Cushing�s Disease
Cushing�s disease or Cushing syndrome is when the body is exposed to high levels of cortisol for a long time. Studies show that when there is a loss of cellular volume to the corticosteroid�s levels in the body and it could be responsible. When there is too much cortisol being produced in the body, it is one of the signs of Cushing syndrome. Some of the other signs include:
Weight gain
Fatty tissue deposits around the midsection, face, upper back and between the shoulders
Pink or purple stretch marks
Thinning, fragile skin that bruises easily
Slow healing cuts, insect bites and infections
Acne
Muscle weakness
Cognitive difficulties
Loss of emotional control
Since stress does play a role in the endocrine system and the neurological system, there are nearly 80 years of research on how much focus has been on the various levels of the HPA (hypothalamic-pituitary-adrenal) axis and the hormones it produces. It shows that glucocorticoids as the mediators for the stress effects on the hippocampus and being the contributing factor for stress-associated psychopathologies.
Conclusion
The hippocampus is located in the temporal lobe of the brain. This S-shaped structure can be easily damaged due to stress and other neurological factors that can affect the entire body and its systems. When harmful factors affect the hippocampus, it can lead the hormones that are producing to become imbalanced and cause dysfunction. Some products are here to make sure that the endocrine system is functioning properly and supporting the metabolic system, the gastrointestinal system, as well as making sure the hormones are balanced.
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.
References:
Anand, Kuljeet Singh, and Vikas Dhikav. �Hippocampus in Health and Disease: An Overview.� Annals of Indian Academy of Neurology, Medknow Publications & Media Pvt Ltd, Oct. 2012, www.ncbi.nlm.nih.gov/pmc/articles/PMC3548359/.
Dresden, Danielle. �Hippocampus: Function, Size, and Problems.� Medical News Today, MediLexicon International, 7 Dec. 2017, www.medicalnewstoday.com/articles/313295.php.
Felman, Adam. �Hypertension: Causes, Symptoms, and Treatments.� Medical News Today, MediLexicon International, 22 July 2019, www.medicalnewstoday.com/articles/150109.php.
Kim, Eun Joo, et al. �Stress Effects on the Hippocampus: a Critical Review.� Learning & Memory (Cold Spring Harbor, N.Y.), Cold Spring Harbor Laboratory Press, 18 Aug. 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC4561403/.
Team, Mayo Clinic. �Cushing Syndrome.� Mayo Clinic, Mayo Foundation for Medical Education and Research, 30 May 2019, www.mayoclinic.org/diseases-conditions/cushing-syndrome/symptoms-causes/syc-20351310.
Stomach pain, burning, or aching 1-4 hours after eating?
If you are experiencing any of these situations, then you might be experiencing low glycine levels in your body.
Glycine
Glycine is a vital amino acid that is beneficial to the body. It helps support the gastrointestinal system, the neurological system, the musculoskeletal system, and the body�s metabolism from harmful factors that can cause the human body to malfunction. Glycine is even a neurotransmitter and can help increase glutathione in the brain by providing anti-inflammatory effects. Glycine provides a sweet taste when it is consumed in the body. Even though glycine has a crucial role in the human body, the amino acid has received little to no attention until recently.
The fantastic thing about glycine is that it is a “non-essential” amino acid. What this means is that the body can make glycine by itself and distribute it to the necessary systems that need glycine. This is different from the “essential” amino acids since some nutrients and vitamins must come from the food diet themselves. When there is a mild deficiency of glycine, it is not harmful to the body; however, when there is a severe shortage of glycine, it can lead to immune response failure, slow body growth, and abnormal nutrient metabolism.
Glycine for The Brain
Since glycine is a neurotransmitter for the brain, it composes both excitatory and inhibitory capacities. For the excitatory capacity function, glycine serves as the antagonist for NMDA receptors for the brain. For inhibitory capacities, glycine helps increase the neurotransmitter serotonin. Studies show that serotonin is the ancestor of melatonin. When the levels are increased due to glycine supplements, the beneficial factors it causes can help reduce insomnia and provide better sleep quality.
Glycine on Sleep
Despite being a massive impact on serotonin, glycine has been known to be used as a therapeutic option for individuals to improve their sleep quality as a novel and safe approach.� Studies show that glycine can increase the blood flow to extremities by reducing the body�s core temperature, which is an important signal to initiate sleep. When this happens, glycine can increase a person�s time when they are in REM sleep, providing the person to have a good night’s sleep. Further research shows that glycine can inhibit the stimulatory orexin neurons that are responsible for arousal and energy homeostasis, which is critical and can induce non-REM sleep or even night waking.
Glycine�s Cognitive Effects
There are many beneficial cognitive effects that glycine has to offer. Research shows that the beneficial effect of glycine can help improve episodic memory in young and middle-aged adults. This can be beneficial for patients who have schizophrenia, Parkinson’s disease, and Huntington’s disease. Additional research also shows that patients who have Alzheimer’s disease use glycine as energy production for their brains.
Glycine Osteoprotective Effects
There is even more information on glycine supplementation, providing estrogen-like osteoprotective effects for menopausal women. The research shows that glycine helps decreased weight gain and providing an increase in vaginal weight gain caused by ovariectomy. Many healthcare providers recommend their female patients that have menopause to use glycine in their diet.
More Glycine Effects
Since glycine is a non-essential amino acid and a neurotransmitter for the central nervous system, this supplement can help supple muscle, bone, and connective tissue with collagen. Glycine has a small R group, which forms a triple helix structure that makes up of tropocollagen. In the body, 33% of all collagen is composed of glycine. Collagen levels in the body can decrease naturally due to anyone getting old. When this happens, inflammatory symptoms like arthritis occur. Researchers hypothesize that supplemental doses of glycine can strengthen joints and prevent reactive arthritis by blunting cytokine release by increasing chloride influx in the body.
Glycine is one of the three amino acids that can help aid the production of glutathione for the human body. Since this amino acid is a scavenger antioxidant, it will oppose proinflammatory signals from hydrogen peroxide. Studies show that glycine supplementation plays a vital role in balancing the redox reactions caused by metabolic syndrome in the human body and protecting patients from oxidative damage. There is even more research as a study stated that glycine has a vital role in the metabolism and nutrition of mammals and humans. Since glycine protects from inflammation and has fantastic health benefits for the body, when there are decreased levels of glycine in the body, it can be linked to metabolism-related disorders like type 2 diabetes and fatty liver disease.
Glycine provides cytoprotective effects on the liver and gastrointestinal tract by conjugating bile acids. This is crucial because glycine plays a role in helping lipids to be digested and lipid-soluble vitamins to be absorbed in the body. In alcohol-induced hyperlipidemia, studies have shown that glycine can reduce alcohol levels in the bloodstream while also retaining the membrane integrity by reducing lipid levels. Glycine can even protect the stomach and intestines from damages caused by gastrointestinal disorders. Since glycine can maintain enterocyte integrity and prevent apoptosis, its anti-inflammatory effects can fight oxidative stress. They can provide the requirements to the intestines and the gut in the body.
Conclusion
Glycine is a vital amino acid that provides anti-inflammatory properties for not only the body’s metabolism but also helps the gastrointestinal system. With more and upcoming research about glycine, it is essential for this amino acid to continue to provide outstanding effects to the human body and to make sure that it functions properly. When harmful factors start entering the body, or there is a glycine deficiency, it can cause the body to malfunction. So incorporating glycine-rich foods in the daily diet can help alleviate the symptoms gradually. Some products are beneficial for the body since they help support the immune system and make sure the body is functioning.
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.
References:
Bannai, Makoto, et al. �Oral Administration of Glycine Increases Extracellular Serotonin but Not Dopamine in the Prefrontal Cortex of Rats.� Wiley Online Library, John Wiley & Sons, Ltd (10.1111), 17 Mar. 2011, onlinelibrary.wiley.com/doi/full/10.1111/j.1440-1819.2010.02181.x.
D�az-Flores, Margarita, et al. �Oral Supplementation with Glycine Reduces Oxidative Stress in Patients with Metabolic Syndrome, Improving Their Systolic Blood Pressure.� Canadian Journal of Physiology and Pharmacology, U.S. National Library of Medicine, Oct. 2013, www.ncbi.nlm.nih.gov/pubmed/24144057.
File, S E, et al. �Beneficial Effects of Glycine (Bioglycin) on Memory and Attention in Young and Middle-Aged Adults.� Journal of Clinical Psychopharmacology, U.S. National Library of Medicine, Dec. 1999, www.ncbi.nlm.nih.gov/pubmed/10587285.
Griffin, Jeddidiah WD, and Patrick C Bradshaw. “Amino Acid Catabolism in Alzheimer’s Disease Brain: Friend or Foe?” Oxidative Medicine and Cellular Longevity, Hindawi Publishing Corporation, 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5316456/.
Kawai, Nobuhiro, et al. �The Sleep-Promoting and Hypothermic Effects of Glycine Are Mediated by NMDA Receptors in the Suprachiasmatic Nucleus.� Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, Nature Publishing Group, May 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC4397399/.
Kim, Min-Ho, et al. “Estrogen-like Osteoprotective Effects of Glycine in Vitro and in Vivo Models of Menopause.” Amino Acids, U.S. National Library of Medicine, Mar. 2016, www.ncbi.nlm.nih.gov/pubmed/26563333.
Li, X et al. “Dietary Glycine Prevents Peptidoglycan Polysaccharide-Induced Reactive Arthritis in the Rat: Role for Glycine-Gated Chloride Channel.” Infection and Immunity, American Society for Microbiology, Sept. 2001, www.ncbi.nlm.nih.gov/pmc/articles/PMC98707/.
McCarty, Mark F, et al. �Dietary Glycine Is Rate-Limiting for Glutathione Synthesis and May Have Broad Potential for Health Protection.� The Ochsner Journal, The Academic Division of Ochsner Clinic Foundation, 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC5855430/.
Razak, Meerza Abdul, et al. �Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review.� Oxidative Medicine and Cellular Longevity, Hindawi, 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5350494/.
Ross, Krista Anderson. �Glycine: Another Tool for the Hormone and Sleep Balancing Kit.� Doctor’s Data Specialty Testing Clinical Laboratory, 3 Dec. 2019, www.doctorsdata.com/resources/uploads/newsletters/Glycine’s-Role-in-Sleep-and-Hormone-Balancing.html.
Microbes have multicellular hosts and can have many effects on the host�s health and well-being. Researchers have stated that microbes influence metabolism, immunity, and behavior on the human body. One of the most important but understudied mechanisms that microbes have is that they can involve hormones. In the presence of gut microbiota, specific changes in hormone levels can correlate in the gut. The gut microbiota can produce and secrete hormones, respond to the host hormones, and regulate their expression levels. There is also a link between the endocrine system and the gut microbiota as more information is still being researched.
The Gut to Hormone Connection
Since the human microbiome contains a vast array of microbes and genes that shows a higher complexity. Unlike other organs in the body, the gut microbiota’s function is not fully understood yet but can be disrupted easily by antibiotics, diet, or surgery. The best-characterized function is how the gut microbiota interacts with the endocrine system in the body.
Emerging research has indicated that the gut microbiome plays a central role in regulating estrogen levels within the body. When the estrogen hormone levels are too high or too low, it can lead to the risk of developing estrogen-related diseases like endometriosis, polycystic ovary syndrome, breast cancer, and prostate cancer to males and females.
The gut to hormone connection is essential since the gut is one of the producers to create hormones that travel through the entire body system. With the endocrine system is being involved, it is the first network to produce and transport hormones to the organs that need the hormones to function. When there is an imbalance of hormones in the human body, it can disrupt all the other hormones.
The gut microbiota influences nearly every hormone that the endocrine system creates, including:
The thyroid hormones
Estrogen hormones
Stress hormones
Thyroid Hormones
If the gut has inflammation, then the hormones in the body will create an excessive or low quantity in the body. If the endocrine glands like thyroid, are producing a low quantity of hormones and the gut can be imbalanced and lead to hypothyroidism. When there is low microbial diversity in the gut, studies have shown that the low microbial diversity is linked to high TSH (thyroid-stimulating hormone) levels. The excessive quantity of thyroid hormones can lead to hyperthyroidism. Both hyperthyroidism and hypothyroidism can cause symptoms like irritability, anxiety, poor memory, and many symptoms that can affect the body.
“If you are experiencing excessive belching, burping, bloating, difficult bowel movements difficulty digesting proteins and meats; undigested food found in stools, digestive problems subside with rest and relaxation or any symptoms. Then this article will give you a better understand what is happening with the gut and how hormones can affect the gut system.”
Estrogen Hormones
The gut and an individual’s hormones are meant to be in communication with each other. They not only support each other, but they also work together to make sure the body is running smoothly. Studies have found out that the gut’s intestinal cells have special receptors for hormones that allow them to detect any hormonal shifts that affect the body.
Since estrogen is typically associated with women, it is common that men need the right amount of estrogen levels to function. The gut microbiota is the key regulator of leveling and circulating estrogen in the body. The microbes produce an enzyme called beta-glucuronidase, which then converts the estrogen hormone to its active form.
The gut microbiome can regulate estrogen levels by functioning a specific bacteria in the microbiome called estrobolome. Estrobolome is the aggregates of enteric bacterial genes that are capable of metabolizing estrogen. It might affect women’s risk of developing postmenopausal estrogen receptor-positive breast cancer. The estrobolome is highly essential to keep estrogen levels in the body at a stable state.
In the gut microbiota, both the estrogen and progesterone hormones can impact the guts’ motility and peristalsis ( The rhythmic movement of the intestines that move food through the stomach and out of the body) by playing opposing roles in the guts� motility. Progesterone helps slow down the gut�s motility by relaxing the smooth and slowing transit the time the food is moving out of the body. Estrogen helps increase the contraction of the smooth muscles in the intestines. When the estrogen hormones are leveled right, it can help keep the gut moving smoothly and help increase the diversity of the body�s microbiomes, which is a good thing for the immune system.
Stress Hormones
Stress hormones or cortisol plays a massive part in the gut microbiota. Since cortisol hormones connect to the brain, it sends the signals to the gut and vice versa. If it is a short stressor like getting ready for a presentation or a job interview, the person will feel “butterflies” in their gut. The longer stressors, for example, like having a highly stressful job or feeling anxious consistently, can lead to chronic illnesses in the gut like inflammation or leaky gut. Since the hormone and gut connection is in sync with the gut and brain connection, it is crucial to lowering the cortisol levels to a stable state for a healthy functional body.
Conclusion
The gut and hormone connections are profoundly meaningful since they are linked closely together. When there is a disruption on the gut, it can cause hormones to be imbalanced, causing many disruptions like inflammation and leaky gut. When there is a disruption in the hormones, it can disrupt the gut as well by negatively shifting the gut’s microbiome. So to ensure that the gut is functioning correctly, it is crucial to eat food that contains probiotics and is fermented to keep the gut flora healthy. Some products can help counter the metabolic effects of temporary stress and supporting estrogen metabolism by incorporating other essential nutrients and cofactors to support the endocrine system.
October is Chiropractic Health Month. To learn more about it, check out Governor Abbott�s declaration on our website to get full details on this historic moment.
The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or chronic disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .
References:
Author, Guest. �How Your Gut Microbiome Influences Your Hormones.� Bulletproof, 21 Aug. 2019, www.bulletproof.com/gut-health/gut-microbiome-hormones/.
Evans, James M, et al. �The Gut Microbiome: the Role of a Virtual Organ in the Endocrinology of the Host.� The Journal of Endocrinology, U.S. National Library of Medicine, 28 Aug. 2013, www.ncbi.nlm.nih.gov/pubmed/23833275.
Kresser, Chris. �The Gut�Hormone Connection: How Gut Microbes Influence Estrogen Levels.� Kresser Institute, Kresserinstitute.com, 10 Oct. 2019, kresserinstitute.com/gut-hormone-connection-gut-microbes-influence-estrogen-levels/.
Kwa, Maryann, et al. �The Intestinal Microbiome and Estrogen Receptor-Positive Female Breast Cancer.� Journal of the National Cancer Institute, Oxford University Press, 22 Apr. 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC5017946/.
Neuman, Hadar, et al. �Microbial Endocrinology: the Interplay between the Microbiota and the Endocrine System.� OUP Academic, Oxford University Press, 20 Feb. 2015, academic.oup.com/femsre/article/39/4/509/2467625.
Szkudlinski, Mariusz W, et al. �Thyroid-Stimulating Hormone and Thyroid-Stimulating Hormone Receptor Structure-Function Relationships.� Physiological Reviews, U.S. National Library of Medicine, Apr. 2002, www.ncbi.nlm.nih.gov/pubmed/11917095.
Wieselman, Brie. �Why Your Gut Health and Microbiome Make-or-Break Your Hormone Balance.� Brie Wieselman, 28 Sept. 2018, briewieselman.com/why-your-gut-health-and-microbiome-make-or-break-your-hormone-balance/.
IFM's Find A Practitioner tool is the largest referral network in Functional Medicine, created to help patients locate Functional Medicine practitioners anywhere in the world. IFM Certified Practitioners are listed first in the search results, given their extensive education in Functional Medicine
