Back Clinic Chiropractic. This is a form of alternative treatment that focuses on the diagnosis and treatment of various musculoskeletal injuries and conditions, especially those associated with the spine. Dr. Alex Jimenez discusses how spinal adjustments and manual manipulations regularly can greatly help both improve and eliminate many symptoms that could be causing discomfort to the individual. Chiropractors believe among the main reasons for pain and disease are the vertebrae’s misalignment in the spinal column (this is known as a chiropractic subluxation).
Through the usage of manual detection (or palpation), carefully applied pressure, massage, and manual manipulation of the vertebrae and joints (called adjustments), chiropractors can alleviate pressure and irritation on the nerves, restore joint mobility, and help return the body’s homeostasis. From subluxations, or spinal misalignments, to sciatica, a set of symptoms along the sciatic nerve caused by nerve impingement, chiropractic care can gradually restore the individual’s natural state of being. Dr. Jimenez compiles a group of concepts on chiropractic to best educate individuals on the variety of injuries and conditions affecting the human body.
Health coaches are becoming more and more crucial as modern medicine continues to improve. Now more than ever, the health care field is progressing at high speeds and professionals do not always have the available time some patients desire. Here is where health coaches become involved. Basically, the position of a health coach was produced to fill the emptiness in several doctor offices. Many physicians contribute but do not have the time or resources to assist each individual and aid in constructing healthy habits on a day to day basis. However, health coaches are available to be a supportive mentor that assists and guides patients in making healthy lifestyle changes. Many patients who seek help to change their lifestyle are those suffering from some kind of chronic pain, headaches, or joint inflammation.
In the previous weeks, we have defined and explained what a health coach is and what they really do, as well as the first two steps a health coach might take with a patient. Throughout this article, the third and fourth steps will be broken down and analyzed.
Need a refresher? No problem!
Health Coaching in El Paso: Part 1 can be found by clicking here.�
Health Coaching in El Paso: Part 2 can be found by clicking here.�
Step 3: Building A Plan For Action
Once the health coach understands the values and goals of the patient, a plan for change can get mapped out. One thing that is unique about building a plan, is that the health coach encourages the patient to have a say in it and contribute to building the plan. The ways of medicine have changed, and this aspect is one of them. Before, many patients would sit silently as doctors instructed them on their new protocol. However, it has been shown that patients who build a plan of action with the practitioner, are more likely to comply and complete a program.
In addition to this, the perspective of the patient can help maintain expectations and keep the plan of action at a realistic timeline. The health coach will offer their suggestions during this process as well as their perspective. Often times, this will help the patient break down their overall goal, into smaller more specific goals or tasks.
As soon as the overall goals are broken down into specific tasks, the health coach will then map out the process to complete these tasks. It can be simple to overlook small steps when thinking of a bigger picture, so the health coach will provide tools to better help the patient understand.
An example of this would be for a patient who wants to lose weight. Mapping out these tasks will have an end result that looks similar to these:
� I will try a new fruit and vegetable every day this week and identify what I enjoy
� I will think of different, creative ways to work movement into my day, such as finding a walking trail in my neighborhood
� I will always keep a water bottle with me and refill it every two hours
� I will cook dinner two nights this week
� I will go for a walk after dinner every day this week
By providing the patients with these smaller tangible tasks, the patient now has “homework” in a sense to complete these throughout the week. The health coach will set a deadline with these tasks and check-in with the patient regularly to ensure they are on track.
Step 4: Tracking Progress And Results
Before progress can be tracked, the health coach will take into consideration the patient’s goal and determine how often the patient will need to come in for follow-ups. For many patients, a combination of follow up techniques are used. Health coaches understand that in-person is not always the most convenient and does not always fit into the patient’s schedule. If this is the scenario, health coaches work around that to create follow-ups by using some in-person visits, some phone conversations, or other virtual check-in meetings that are HIPAA compliant.
Often times, during a lifestyle change patients may become confused or discouraged. It is important to remember that this is normal and progress is not always a straight line up, but rather includes bumps along the way. In order to better help the patient, the health coach will provide them with a helpful “where to turn” guide.
As humans, at different times we require different types of support. The where to turn guide will be a supporting reminder of things to do to counteract these feelings when they arise. Items included in this guide will be ideas such as:
� Pursuing a hobby, like dancing or playing an instrument
� Getting out in nature
� Starting a mindfulness practice
� Making art, like drawing or writing
� Joining a community, religious, or spiritual group
In addition to these activities, the health coach will determine with the patient what kind of support (internal or external) is appropriate depending on the situation.
Lastly,� progress does not always look like a dip in the number on the scale. Progress can come in many different forms. In order to help the patient appreciate and realize all the progress they are making, a health coach will ask questions like:
1. How can you appreciate your progress?
2. How would you describe the benefits of your experience?
3. What�s been good about this experience?
4. How have you grown?
As mentioned earlier, a health coach is important to have as they help one realize all the steps it truly takes to be successful and reach their health goals. There are many critical steps that are easily overlooked when the big picture is on their minds. The final two steps that a health coach will work on with a patient is to help them visualize their best self and to create a plan for resiliency. These two topics will be discussed in the next article.
�Using a health coach to complete a lifestyle change is similar to the work of going to therapy. One must be willing to accept the tools and resources they are givien, and actually do the work provided or it will not produce results. If a patient is truly serious about completing a lifestyle change, using a health coach is an extremly beneifical resource! As one can see, they work with the patients to hammer down tasks and ideas that a patient might not have orignally thought of. By utilizing a health coach, the patient has a higher chance of reaching their goals. – Kenna Vaughn, Senior Health Coach
All information and resources for this post came from an Integrative Practioner article titled, “A Six-Step Approach To Health And Wellness Coaching: A Toolkit for Practice Implementation” and can be found by clicking here; as well as listed below in the proper bibliography.
*The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.
Miller, W. and Rose, G. (1991). Motivational Interviewing: Preparing People to Change Addictive Behavior. Guilford Publications.
Pecoraro, Wendy. �A Six-Step Approach to Health and Wellness Coaching: A Toolkit for Practice Implementation.� Official Media Integrative Practitioner, 17 Oct. 2019, www.integrativepractitioner.com/resources/e-books/a-six-step-approach-to-health-and-wellness-coaching-a-toolkit-for-practice-implementation.
Do you often feel energy level drops in the afternoon? Do you often crave sugar and sweets in the afternoon? Do you often have difficulty concentrating before eating? Various medical conditions can affect the overall health of our body and mind. However, research studies have found that anemia caused by iron deficiency can tremendously affect our brain health. �
Iron deficiency is considered to be one of the most prevalent nutritional health issues, affecting approximately 2.5 billion people worldwide. In developing countries, about 40 percent of children and 50 percent of pregnant women have an iron deficiency. Iron is an essential mineral found in approximately 5 percent of the earth�s crust, however, inefficiency in absorption, low iron levels in staple grain foods, and a variety of medical conditions can make iron deficiency a common problem among humans. In first world countries, iron deficiency is still one of the most common nutrient deficiencies. �
What Causes Iron Deficiency and Anemia?
Poor iron intake and increased iron loss, generally through bleeding or breastfeeding, are several of the main causes of iron deficiency. Pregnant women, breastfeeding women, women with heavy periods, children or picky eaters, vegetarians and vegans, as well as people with digestion health issues which cause decreased iron absorption like celiac disease or post gastric bypass, and people with increased bleeding, such as cancer, ulcers, gastritis, or parasites, are generally at higher risk for iron deficiency. High calcium intake, by way of instance, children who drink a lot of milk, can also affect iron absorption, together with drugs and/or medications, such as antacids and proton-pump inhibitors for gastroesophageal reflux disease. �
Although low iron levels are well-known for causing anemia because red blood cells need iron as a part of hemoglobin, iron is also needed for the brain and nerves. Severe iron deficiency in younger children can ultimately cause irreversible damage to cognition and result in lower IQ and developmental delays, especially during the most fundamental stages of human development and up to 16 months of age. Even in adults. the most common symptoms associated with iron deficiency are generally neurological symptoms, including fatigue, brain fog, and restless legs that cause insomnia, among other symptoms. �
Pica, the abnormal behavioral compulsion to eat non-nutritional foods like dirt or clay, is tremendously prevalent in regions of the world where iron deficiency is common. In the developed world, pica is a rare health issue, however, it still frequently occurs in children, pregnant women, and among other groups of people that are at higher risk for iron deficiency, including people who have had gastric bypass. Non-neurological symptoms associated with iron deficiency ultimately include pallor, generalized weakness, and higher than usual heart rate along with shortness of breath, especially with exertion. �
What are the Symptoms of Iron Deficiency?
As previously mentioned above, iron deficiency can cause problems associated with cognition and neurological health issues, such as restless legs and insomnia. The exact mechanisms of why this happens are unknown, however, without enough iron in the brain and nerves, there are problems with neurotransmitter signaling, the development of nerve insulation known as myelin, and brain energy metabolism. Reduced central neuron processing is considered to be one of the most critical problems associated with iron deficiency, which can be a cause of psychiatric symptoms and ongoing psychiatric problems. �
Occasionally, iron deficiency may also cause anxiety, depression, irritability, and even poor concentration and restlessness. By way of instance, iron deficiency has a much higher prevalence in children with ADHD but the symptoms can improve with iron supplements. People with iron deficiency have higher risks of developing psychiatric disorders, especially ADHD, and developmental disorders. Evidence has demonstrated that iron deficiency can cause a variety of other health issues. �
Iron enters the brain through the blood-brain barrier via transferrin receptors. Iron uptake into the brain is highly regulated but it also does highly depend on the iron status of the human body. Therefore, people with low iron levels will have much less iron going into the brain and people with high iron levels will have much more iron going into the brain. Several regions of the brain also appear to gather iron and have higher levels than others. Moreover, neurological symptoms can manifest before developing iron deficiency anemia. Thus, healthcare professionals can’t rule out iron deficiency anemia from the most commonly utilized basic screening test, a complete blood count. A better general screen involves ferritin levels, where less than 15 ng/ml presents the diagnosis for iron deficiency but less than 40 ng/ml presents with fatigue, brain fog, restless legs, and other neurological symptoms. Ferritin on its own can be misleading in populations of people with chronic inflammation, including people on dialysis, where ferritin can be high even if the person is diagnosed with iron deficiency. Furthermore, a full iron workup includes hemoglobin, MCV, ferritin, total iron-binding capacity, serum iron, and transferrin saturation. �
What is the Treatment for Iron Deficiency Anemia?
Treating iron deficiency is considerably simple through the utilization of iron supplements or in mild or moderate cases by encouraging the consumption of foods that are high in iron. Occasionally, people with severe absorption health issues will need iron transfusions intravenously. Meat and seafood are the best sources of easily absorbable heme iron, however, non-heme iron is naturally found in leafy greens, beans, and nuts. Make sure to talk to your doctor if you have iron deficiency. �
It is ultimately essential to make sure if you have iron deficiency before treating it with increased amounts of iron supplements. With the exception of blood loss, the only way to reduce excess iron is through the process of skin cells flaking off. Therefore, adult men who take a lot of iron supplements and people with a genetic tendency to absorb more iron from foods are at a higher risk of developing a medical condition, known as hemochromatosis or severe iron overload. �
Excess iron is stored in the liver and can lead to scarring of the liver, known as cirrhosis. Iron overload can also lead to joint and hormonal problems and it can also cause a bronze-ish skin color. Symptoms of hemochromatosis include joint pain, fatigue, and low sex drive as well as a higher risk of developing diabetes. High serum iron is associated with health issues like high blood pressure. People who aren�t iron deficient can consider regular blood donations to prevent accidental iron overload. Iron is one of those types of minerals that should neither be too high or too low but rather, just right. More research studies, especially clinical trials analyzing common medical conditions, such as restless legs, insomnia, and ADHD, are fundamental to help healthcare professionals understand the relationship between iron deficiency anemia and brain health. �
Recent research studies have demonstrated that iron deficiency anemia may be associated with brain health issues. Because the brain and nerves need iron for many functions, iron deficiency can cause a variety of symptoms and medical conditions, including brain fog, fatigue, restless legs with insomnia, anxiety, depression, and cognitive problems, besides anemia or lack of healthy red blood cells. Treatment for iron deficiency anemia may utilize iron supplements, however, it’s important to make sure to talk to a qualified healthcare professional in order to avoid risks and side effects through iron supplementation.� – Dr. Alex Jimenez D.C., C.C.S.T. Insight
Neurotransmitter Assessment Form
The following Neurotransmitter Assessment Form can be filled out and presented to Dr. Alex Jimenez. Symptoms listed on this form are not intended to be utilized as a diagnosis of any type of disease, condition, or any other type of health issue. �
Do you often feel energy level drops in the afternoon? Do you often crave sugar and sweets in the afternoon? Do you often have difficulty concentrating before eating? Various medical conditions can affect the overall health of our body and mind. However, research studies have found that anemia caused by iron deficiency can tremendously affect our brain health. � Iron deficiency is considered to be one of the most prevalent nutritional health issues, affecting approximately 2.5 billion people worldwide. In developing countries, about 40 percent of children and 50 percent of pregnant women have an iron deficiency. Iron is an essential mineral found in approximately 5 percent of the earth�s crust, however, inefficiency in absorption, low iron levels in staple grain foods, and a variety of medical conditions can make iron deficiency a common problem among humans. In first world countries, iron is still considered to be the most common nutrient deficiency. �
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.�
Curated by Dr. Alex Jimenez �
References:
Deans, Emily. �Heavy Metal: Iron and the Brain.� Psychology Today, Sussex Publishers, 29 Nov. 2015, www.psychologytoday.com/us/blog/evolutionary-psychiatry/201511/heavy-metal-iron-and-the-brain.
Additional Topic Discussion: Chronic Pain
Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals, however, chronic pain is different than the average type of pain. With chronic pain, the human body will continue sending pain signals to the brain, regardless if the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient’s mobility and it can reduce flexibility, strength, and endurance.
Neural Zoomer Plus for Neurological Disease
Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual�s reactivity to 48 neurological antigens with connections to a variety of neurologically related diseases. The Vibrant Neural ZoomerTM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention. �
Food Sensitivity for the IgG & IgA Immune Response
Dr. Alex Jimenez utilizes a series of tests to help evaluate health issues associated with food sensitivities. The Food Sensitivity ZoomerTM is an array of 180 commonly consumed food antigens that offers very specific antibody-to-antigen recognition. This panel measures an individual�s IgG and IgA sensitivity to food antigens. Being able to test IgA antibodies provides additional information to foods that may be causing mucosal damage. Additionally, this test is ideal for patients who might be suffering from delayed reactions to certain foods. Utilizing an antibody-based food sensitivity test can help prioritize the necessary foods to eliminate and create a customized diet plan around the patient�s specific needs. �
Formulas for Methylation Support
XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly,�Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic�Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
�
For your convenience and review of the XYMOGEN products please review the following link. *XYMOGEN-Catalog-Download �
* All of the above XYMOGEN policies remain strictly in force.
Biomarkers are molecules that can help diagnose a health issue. These have become important for verifying investigations, choosing the best remedies, and monitoring disease progression. One exception, however, includes biomarkers for neurological diseases. Neurological biomarkers are found in the cerebral spinal fluid (CSF) or, in undetectable amounts, in the blood vessels. The human brain is closely guarded by the blood-brain barrier which protects it from damaging compounds circulating throughout the blood vessels. The blood-brain barrier has made it inaccessible to use these biomarkers. �
Biomarkers may be analyzed using the CSF but this also needs an invasive lumbar puncture process. Biomarker signatures, or recent improvements in discovery, in addition to the ability of clusters of biomarkers, are currently helping to make neurological disorders more treatable and more reachable. Treating and preventing neurological disorders, such as chronic traumatic encephalopathy (CTE), Alzheimer’s disease, Parkinson’s disease, autism, and major depressive disorder, is very likely to become less difficult to diagnose with the recent arrival of neurological biomarkers found in the blood. �
Biomarker for Brain Health Issues
Biomarker signatures, found with panels of high-quality antibodies, are yet another safe and effective tool for evaluating neurological disorders and diseases. Assistant professor of neurology and immunobiology at the University of Arizona College of Medicine at Tucson, Kristian Doyle, utilizes biomarkers to examine how the immune system deals with dead brain tissue. The system eliminates brain tissue with a procedure called liquefactive necrosis following a stroke but the pathophysiology of the procedure is unknown. This information is essential because liquefactive necrosis may be neurotoxic. �
“We utilize multiplex immunoassays to describe inflammation within chronic stroke infarcts in the point of liquefactive necrosis, and to describe changes by ordinary stroke comorbidities,” says Doyle. Because over 10 million individuals survive a stroke every year, Doyle expects that biomarkers may help them monitor the development of liquefactive necrosis and start to tailor remedies that mitigate the secondary harm due to this procedure,” he states. Another connection between inflammation and neurotoxicity is analyzed by Alysson Muotri, professor of molecular and cellular medicine and director of the Stem Cell Program at the University of California, San Diego School of Medicine. The Muotri laboratory uses induced pluripotent stem cells (iPSCs) from individuals with schizophrenia and autism to search for biomarkers of those ailments. �
Muotri’s laboratory started analyzing the cytokine interleukin-6 (IL-6) as a biomarker because evidence indicates that chronic exposure to elevated cytokines might be neurotoxic together with elevated levels associated with depression, autism, and schizophrenia. “The gap of one of the many brain disorders could function as cytokines act on particular types or subtypes of nerves, or within a particular brain area,” states Muotri. His laboratory differentiates iPSCs to cells, which they suspect might be releasing cytokines from patients. Also, because IL-6 can also be involved in immune-inflammatory pathways, Muotri supposes a connection between autism and in utero exposure to infection, such as the Zika virus. �
“Our forecast is that the inflammation caused by Zika vulnerability is sufficient to make a neurotoxic environment which could rewire how the human brain is shaped,” he states. “We see that in mice, therefore, we believe some Zika-exposed children are going to develop autism or have intellectual disabilities” Larger biomarker signatures are available with technologies from CDI Laboratories, which provides microarrays of practical human proteins, including over 20,000 to a single variety, to check the antibodies within human liquid biopsy samples, including blood, serum, plasma, CSF, or tissue lysates. The consequent “autoantibody profile” is a helpful tool for study and for diagnoses or prognoses of individuals. �
“We have worked in the area of biomarker discovery for various neurodegenerative diseases like multiple sclerosis, neuropsychiatric lupus, Alzheimer’s disease, and Parkinson’s disease,” states George Dorfman, director of business development in CDI Laboratories, a spin-off firm located in Baltimore, Maryland, and Mayaguez, Puerto Rico which was created from research in the High Throughput Biology Center at Johns Hopkins University. CDI’s stage is particularly beneficial in building panels for biomarker discovery because researchers can start by utilizing patient samples or banked trials to evaluate resistant profiles of cohorts that reveal specific symptoms or no indications in the event of control trials. �
“This provides us with an inherent candidate biomarker panel that offers advice on the following clinical outcome or curative efficacy, which is confirmed to yield the last panel, then interpreted into the state an ELISA-based kit or any other immunodiagnostic format at the clinical setting,” says Dorfman. “In the event of multiple sclerosis, as a patient grows through measures of this disease, their entire body creates novel antibodies or greater present antibody titers against specific proteins, such as myelination proteins. Our panels may discover these, to provide a notion about exactly what patients’ disease development might seem like, and supply a signature which may be interpreted into another evaluation or an FDA-approved diagnostic” CDI’s technologies have also been utilized to create an autoantibody profile for neuropsychiatric lupus, a beneficial diagnostic tool to ultimately help diagnose a neurological disorder that typically lacks obvious clinical signs. �
Understanding Biomarkers for Brain Health
The amount and types of biomarkers, as well as the quantity of information which researchers have to arrange, can help provide better remedies and prevention methods and techniques. “It ought to be no surprise that researchers spend around 80 percent of the time handling and not assessing statistics,” states Scott Marshall, managing director of translational informatics and diagnostic sciences in Precision for Medicine in Frederick, Maryland. The biomarker data management system, PATH, was made to incorporate any sort of biomarker information for further neurological disease diagnosis. �
“The true power of biomarkers comes if you connect this data to clinical information,” states Marshall. Their biomarker information management system supports translational research and biomarker-guided medicine development and puts no limitation on the number of biomarkers that may be tracked. “It can manage multiple biomarker technologies concurrently, such as complicated flow cytometry, next-generation sequencing, immuno-sequencing, epigenetic profiling, and other varieties of assays measuring biological variant too,” states Marshall. Their kind of “translational informatics” instrument is much more efficient than generating reams of information” with no strategy to acquire actionable insights out of these.” �
Research teams utilize Precision to Medicine’s platform for neuro-related programs that vary from illness pathogenesis to creating complicated signatures that are predictive of treatment response. By way of instance, the system was utilized in a research study including the evaluation of transcriptomic and genomic data in the treatment of major depressive disorder. The outcome is a genomically defined subset of individuals utilizing a probability of improvement. “This type of signature can now be evaluated by means of an assay, which may subsequently be developed to accompany diagnostic or free diagnostic to successfully target the correct individual group,” states Marshall. Biomarker data management systems become more fundamental as distinct kinds of biomarkers are examined collectively, ultimately including proteins and miRNAs. �
Combining kinds of biomarkers will very likely boost their usefulness. “Diagnostics is becoming increasingly more important as we know that the interplay between microRNAs, proteins, DNA, and messenger RNA is necessary,” states Pregibon. Clinical decision-making may profit particularly in which the human brain has been blocked by the blood-brain barrier until lately. “The chance to leverage biomarker-driven targeted treatments means that the sufferers that are more inclined to react to treatments are getting them quicker,” states Marshall. “For researchers, that’s the energy of biomarkers.” �
�
The recent ability to be able to detect neurological biomarkers in the blood, despite the blood-brain barries, is largely due in part to new technological advances in diagnosis and detection. Several of these technologies can ultimately increase sensitivity, however, increased sensitivity can help improve earlier detection or diagnosis of biomarkers for neurological diseases and disorders. Researchers and healthcare professionals currently believe that the presence of these biomarkers may be present earlier than we currently understand, which can help improve health issue diagnosis and treatment. – Dr. Alex Jimenez D.C., C.C.S.T. Insight
Neurotransmitter Assessment Form
The following Neurotransmitter Assessment Form can be filled out and presented to Dr. Alex Jimenez. Symptoms listed on this form are not intended to be utilized as a diagnosis of any type of disease, condition, or any other type of health issue.
Biomarkers are molecules that can help diagnose a health issue. These have become important for verifying investigations, choosing the best remedies, and monitoring disease progression. One exception, however, includes biomarkers for neurological diseases. Neurological biomarkers are found in the cerebral spinal fluid (CSF) or, in undetectable amounts, in the blood vessels. The human brain is closely guarded by the blood-brain barrier which protects it from damaging compounds circulating throughout the blood vessels. The blood-brain barrier has made it inaccessible to use these biomarkers. �
Biomarkers may be analyzed using the CSF but this also needs an invasive lumbar puncture process. Biomarker signatures, or recent improvements in discovery, in addition to the ability of clusters of biomarkers, are currently helping to make neurological disorders more treatable and more reachable. Treating and preventing neurological disorders, such as chronic traumatic encephalopathy (CTE), Alzheimer’s disease, Parkinson’s disease, autism, and major depressive disorder, is very likely to become less difficult to diagnose with the recent arrival of neurological biomarkers found in the blood. �
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.�
Curated by Dr. Alex Jimenez �
References:
Smith, Caitlin. �Biomarkers on the Brain: Putting Biomarkers Together for a Better Understanding of the Nervous System.� Science, 15 Mar. 2018, www.sciencemag.org/features/2017/12/biomarkers-brain-putting-biomarkers-together-better-understanding-nervous-system.
Additional Topic Discussion: Chronic Pain
Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals, however, chronic pain is different than the average type of pain. With chronic pain, the human body will continue sending pain signals to the brain, regardless if the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient’s mobility and it can reduce flexibility, strength, and endurance.
Neural Zoomer Plus for Neurological Disease
�
Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual�s reactivity to 48 neurological antigens with connections to a variety of neurologically related diseases. The Vibrant Neural ZoomerTM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention. �
Food Sensitivity for the IgG & IgA Immune Response
�
Dr. Alex Jimenez utilizes a series of tests to help evaluate health issues associated with food sensitivities. The Food Sensitivity ZoomerTM is an array of 180 commonly consumed food antigens that offers very specific antibody-to-antigen recognition. This panel measures an individual�s IgG and IgA sensitivity to food antigens. Being able to test IgA antibodies provides additional information to foods that may be causing mucosal damage. Additionally, this test is ideal for patients who might be suffering from delayed reactions to certain foods. Utilizing an antibody-based food sensitivity test can help prioritize the necessary foods to eliminate and create a customized diet plan around the patient�s specific needs. �
Formulas for Methylation Support
XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly,�Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic�Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
�
For your convenience and review of the XYMOGEN products please review the following link. *XYMOGEN-Catalog-Download �
* All of the above XYMOGEN policies remain strictly in force.
Lower back pain is a condition that pretty much affects most of us at some point in our lives. Some find:
Sitting
Standing
Walking
can be painfully difficult or helpful, depending on the position or the activity they’re involved in.
Low back pain varies from person to person, yet there remains no consensus on the optimal way to diagnose and treat patients.
Lower back pain can be caused by a multitude of factors and can be difficult to diagnose the exact cause. However, there is an advanced method of diagnosing and treating individuals with musculoskeletal conditions/injuries.
TENS, Transcutaneous Electrical Nerve Stimulation in Physical Therapy. Therapist Positioning Electrodes onto Patient’s Lower Back
Successful treatment
Dividing patients with lower back pain into more similar groups based on the same factors that aggravate and alleviate the pain means that a more custom based treatment plan can be created.
The one size fits all method just doesn’t cut it. A more focused approach for every individual leads to better results.
Patients find that placing their bodies in certain positions and certain physical activities can:
Activate
Aggravate
Deactivate their back pain.
Patients also find the pain being either better or worse.
Understanding why sitting, standing, and walking can change the severity of low back pain can be helpful in diagnosis.
These are important cues that help to diagnose and treat low back pain.
People sit, stand, and walk all day. This is why so much research has been conducted on how these specific positions and activities contribute to low back pain.
Spine Anatomy
The alignment of the spinal column, from the skull to the pelvis, is S-shaped.
The cervical and lumbar spinal segments curve towards the front of the body, and so are lordotic,�while the thoracic spine curves towards the back of the body and is kyphotic.
The amount of curvature does not stay in one place and changes based on body position.
Compared to standing, sitting decreases lumbar lordosis by about 50%.
Changes in lumbar lordosis can relieve pain from certain forms of back pain but can aggravate others.
Picture The Spine Bending
Imagine you are holding a garden hose. Holding it vertically in front of you. The hollow part of the tube represents the spinal canal, the part of the hose facing you is the posterior spinal column, and the part of the hose facing away from you is the anterior spinal column.
Bend the hose in half. The hose on the outward-facing side of the curve will stretch out, while the hose on the inward-facing side of the tube will be compressed.
This exercise helps visualize that an object being bent will experience two forces, either:
Compression
Tension
Increasing lumbar curvature will compress the posterior column�and stretch out the anterior column vertebrae and discs.
Decreasing lumbar curvature will�stretch out�the posterior column and�compress�the anterior column. This is the basis of why certain body positions can relieve back pain symptoms for some people and make it worse for others.
Prolonged sitting, and especially if poor posture is involved, can cause overstretching of spinal muscles.
Arthritis can affect the joints.
The facet joints are posterior based structures and can become compressed with increased curvature. When the facet joints are the primary cause of back pain, patients usually find that sitting improves the pain, while standing and walking make it worse.
When the discs are the pain generator, sitting seems to aggravate the pain as there is more compression in the tissue.
With certain types of disc herniations, sitting can compress the disc to the point that the herniated tissue starts to press against a nerve root causing radicular pain or pain that radiates out to another area of the body like the legs. In this case, walking seems to alleviate the pain.
Spinal Conditions
Various spinal conditions definitely contribute to back pain and have the same presentations and alleviations.
Spinal Stenosis which means the narrowing of the spinal canal. Patients with this type of spine pain improve with leaning forward sitting. This is because the posture increases/opens the size of the canal�and decreases the nerve root compression.
Spondylolisthesis is when one vertebra slips forward over the vertebra right underneath. This is more commonly known as a slipped disc. There are various forms of this condition. But the pain occurs immediately when sitting, bending or walking and is usually relieved when standing still or in a neutral position for short periods.
Sacroiliac Joint Dysfunction comes from the sacroiliac joint becoming inflamed. Pain is usually aggravated when sitting or about to sit. especially when there is added weight on the affected side. This can be difficult to diagnose because of trying to figure out if it’s the hip or low back causing the pain.
Locating the Pain Generator
Sitting, standing, walking low back pain causes are different for everyone. But finding the root cause helps to prescribe the best treatment possible. A chiropractor uses many different techniques to relieve pain. These include:
Applied pressure
Massage
Hands-on manipulation (adjustments)
X-rays
MRI’s
Lab work
Health coaching
Chiropractors don�t prescribe medications, but they do recommend therapeutic, rehabilitative exercises and nutritional lifestyle counseling to help the body heal itself.
Low Back Pain Treatment El Paso, Texas
NCBI Resources
A chiropractor sets up treatment approaches based on the individual. This begins with the natural, non-invasive treatments before moving on to more aggressive techniques. And as an added bonus patient�s who have received chiropractic treatment have experienced improvements to their digestive health and have reported better and deeper sleep after a chiropractic visit.
Do you often feel that your energy levels drop in the afternoons? Do you often feel brain fog or have unclear thoughts and poor concentration? Do you often experience brain fatigue with chronic pain and inflammation? Diet and supplements are essential for overall well-being. However, fish oil omega-3s are a common supplement with a variety of health benefits. �
Fish oil is a well-known supplement that comes from fatty fish, such as sardines, anchovies, mackerel, and salmon. Fish oil has two types of omega-3 fatty acids, known as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), both of which are commonly used to support skin and heart health. Fish oil supplements can also promote brain health, especially when it comes to improving memory and mood problems like depression, as well as a variety of other health issues. The purpose of the following article is to discuss how the omega-3 fatty acids in fish oil may support and promote brain health. �
What Are Fish Oil Omega-3s?
Omega-3 fatty acids, best known as omega-3s, are polyunsaturated fats that offer most of the brain health benefits of fish oil. Fish oil has two main types of omega-3 fatty acids, EPA and DHA. These two omega-3s are found in cell membranes and these also have anti-inflammatory effects in the human body. They are also well-known for their fundamental roles in human development and heart health. EPA and DHA are found in fatty fish and fish oil. Because the majority of people do not eat the recommended amounts of fish, many people probably aren’t getting enough EPA and DHA in their regular diets. �
The human body can make EPA and DHA from another type of omega-3 fatty acid, known as alpha-linolenic acid (ALA). ALA is commonly found in a variety of foods, including walnuts, flaxseeds, chia seeds, canola oil, soybeans, and soybean oil. However, the human body can’t properly turn ALA into EPA and DHA, where healthcare professionals and researchers estimate that approximately less than 10 percent of the amount of ALA you eat is properly turned into EPA or DHA. Fish oil is a good option for people who don�t eat a lot of fish but are still looking to gain the health benefits of omega-3 fatty acids. �
How Do Omega-3s Improve Brain Health?
The omega-3 fatty acids EPA and DHA are essential for normal brain function during all stages of life. EPA and DHA play a fundamental role in the development of a baby�s brain. Several research studies have associated pregnant women�s fish intake or fish oil use with higher scores for their children on brain function and intelligence tests in early childhood. �
These omega-3s are also essential for the regulation of normal brain function throughout life. They are commonly found in the cell membranes of brain cells, preserving cell membrane health and facilitating communication between brain cells. �
When animals are fed diets without omega-3 fatty acids, the amount of DHA in their brains decreases, and they often demonstrate deficits in learning and memory. In older adults, decreased levels of DHA in the blood have ultimately been associated with smaller brain size, a prevalent symptom of accelerated brain aging. Clearly, it is essential to make sure that you get enough omega-3 fatty acids in order to avoid these detrimental effects on brain function and development. �
Fish Oil for Memory
The omega-3s found in fish oil play important roles in brain function and development. There are also claims that fish oil can improve brain function in people with memory problems, such as dementia and Alzheimer�s disease. Alzheimer�s disease affects brain function and quality of life in millions of elderly adults. That’s why finding a supplement or natural remedy that can help improve brain function in this population of individuals would be a major, if not a life-changing discovery. �
Unfortunately, a review of the research study found no compelling evidence that omega-3 supplements like fish oil can improve brain function in people with dementia and Alzheimer�s disease. However, several research studies suggest that fish oil supplements may improve brain function in people with more mild types of brain health issues, including mild cognitive impairment (MCI) or age-related cognitive decline. Although these types of brain conditions aren�t as severe as dementia and Alzheimer�s disease, they can still result in memory loss and sometimes other types of impaired brain function. �
One research study gave 485 older adults with age-related cognitive decline either 900 mg of DHA or a placebo every day. After 24 weeks, those taking DHA performed better on memory and learning tests. Similarly, another research study investigated the effects of taking 1.8 grams of omega-3 fatty acids from fish oil supplements daily for 24 weeks. The researchers found improvements in brain function in people with MCI but there were no benefits for those with dementia and Alzheimer�s disease. According to the research study, fish oil supplements may be most beneficial when people start taking them in the early stages of brain function decline. If you wait too long, fish oil may be of little benefit to brain health. �
Fish Oil for Depression
Finding treatments for depression and other mental health issues is still a public health priority. A recent review of several research studies concluded that taking fish oil supplements improved symptoms in people with depression. However, the greatest improvements in depressive symptoms seemed to occur in people who were also taking antidepressants. In addition, people seemed to experience greater effects when the fish oil supplement also had higher doses of EPA. �
It is still unclear how EPA and omega-3s help improve depressive symptoms. Researchers suggest that it may be associated with their effects on serotonin and serotonin receptors in the brain. Others have proposed that omega-3s from fish oil can improve depressive symptoms through their anti-inflammatory effects. Additional evidence suggests that fish oil may also help improve other mental health issues like borderline personality disorder and bipolar disorder. However, more high-quality research studies are required before the medical community can make definitive recommendations. �
Should You Take Fish Oil for Your Brain Health?
According to the evidence gathered from a variety of research studies, you may want to consider taking fish oil omega-3 fatty acids if you are experiencing mild memory loss, depression, or if you want to improve your overall brain health.�There are no official recommendations regarding how much omega-3s from fish oil you need to take to see benefits in brain function and mental health. The amounts of fish oil omega-3 fatty acids used in the research studies varied from each clinical trial. �
The US Food and Drug Administration has set a safe and effective limit for the intake of omega-3 fatty acid supplements to be at 3,000 mg per day. The European Food Safety Authority has set their recommendation a little higher, at no more than 5,000 mg per day. Taking 1,000 to 2,000 mg of omega-3 fatty acids from fish oil daily is likely a good starting point, which is under the recommended limit. People with depression should choose fish oil supplements with higher amounts of EPA. �
It is essential to read labels carefully when evaluating fish oil supplements. A 1,000-mg capsule of fish oil may have less than 500 mg of actual omega-3 fatty acids but this can vary for each brand. In general, fish oil supplements are considered to be safe and effective at dosages under those that were previously mentioned. Make sure you talk with a healthcare professional before taking fish oil omega-3 fatty acid supplements. Because research studies have reviewed their potential effects on blood clotting, this is especially important if you are taking blood-thinning medications or have an upcoming surgery. �
EPA and DHA are omega-3 fatty acids in fish oil that are fundamental for normal brain function and development. People with mild decline in memory or brain function and mood changes like depression may consider taking omega-3s from fish oil because these can improve symptoms and overall brain health. Although fish oil is typically praised for its benefits for heart health, it also has incredible effects on brain and mental health that are worth mentioning.�- Dr. Alex Jimenez D.C., C.C.S.T. Insight
Neurotransmitter Assessment Form
The following Neurotransmitter Assessment Form can be filled out and presented to Dr. Alex Jimenez. Symptoms listed on this form are not intended to be utilized as a diagnosis of any type of disease, condition, or any other type of health issue. �
Do you often feel that your energy levels drop in the afternoons? Do you often feel brain fog or have unclear thoughts and poor concentration? Do you often experience brain fatigue with chronic pain and inflammation? Diet and supplements are essential for overall well-being. However, fish oil omega-3s are a common supplement with a variety of health benefits. �
Fish oil is a well-known supplement that comes from fatty fish, such as sardines, anchovies, mackerel, and salmon. Fish oil has two types of omega-3 fatty acids, known as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), both of which are commonly used to support skin and heart health. Fish oil supplements can also promote brain health, especially when it comes to improving memory, mood problems like depression, as well as neurological diseases and other health issues. The purpose of the article above was to discuss how the omega-3 fatty acids in fish oil support and promote brain health. �
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.�
Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals, however, chronic pain is different than the average type of pain. With chronic pain, the human body will continue sending pain signals to the brain, regardless if the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient’s mobility and it can reduce flexibility, strength, and endurance.
Neural Zoomer Plus for Neurological Disease
Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual�s reactivity to 48 neurological antigens with connections to a variety of neurologically related diseases. The Vibrant Neural ZoomerTM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention. �
Food Sensitivity for the IgG & IgA Immune Response
Dr. Alex Jimenez utilizes a series of tests to help evaluate health issues associated with food sensitivities. The Food Sensitivity ZoomerTM is an array of 180 commonly consumed food antigens that offers very specific antibody-to-antigen recognition. This panel measures an individual�s IgG and IgA sensitivity to food antigens. Being able to test IgA antibodies provides additional information to foods that may be causing mucosal damage. Additionally, this test is ideal for patients who might be suffering from delayed reactions to certain foods. Utilizing an antibody-based food sensitivity test can help prioritize the necessary foods to eliminate and create a customized diet plan around the patient�s specific needs. �
Formulas for Methylation Support
XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly,�Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic�Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
�
For your convenience and review of the XYMOGEN products please review the following link. *XYMOGEN-Catalog-Download �
* All of the above XYMOGEN policies remain strictly in force.
To get the best treatment for upper or mid-back back pain, you should understand what may be causing it.
A doctor or chiropractor can help you figure out what is contributing to your back pain, then determine the root cause, and set up a treatment outline. Here are some of the more common causes.
Improper posture
Poor posture is one of the leading causes of upper back pain because so many people spend their workdays sitting at some station for most if not the entire day. Sitting with a:
Rounded back
Shoulders hunched forward
Just these two positional behaviors can put massive stress on the back muscles.
Getting into bad habits and not sitting properly, and sitting for so many hours a day is a sure way to bring out some form of body pain.
Not lifting objects properly
When picking something up, you should use proper lifting body mechanics to protect the spine.
Not using proper lifting form can definitely cause injury/s.
Overloaded backpack/purse
Anyone who uses backpacks and big purses is at risk for upper back injury and consistent pain.
Over-loading backpacks and purses can be dangerous to the spine and shoulders.
Also not wearing the backpack correctly, for example just using one strap causes imbalance, which leads to soreness, and that leads to injury.
Trauma Accident
Auto accidents, slips, and falls can cause all kinds of injuries including upper back pain.
Fracturing a vertebra or a spinal bone is possible.� When this happens part of the vertebrae presses on a spinal nerve and can cause pain.
Osteoporosis
This condition affects the bones, and an individual might not know they have osteoporosis until some type of fracture like a vertebral compression fracture.
It weakens the bones, which can affect how the body supports its weight. This opens the door for fractures.
Weakened vertebrae won’t support the body’s weight correctly, so the muscles, ligaments, and tendons have to work harder.
That leads to:
Sprains
Strains
Muscle fatigue
Various injuries
Kyphosis
The spine is supposed to curve outwards in the upper back; the curve is called kyphosis or a kyphotic curve.
With problematic kyphosis, the spine begins to curve outward in an exaggerated fashion that can lead to back pain.
Scoliosis
Scoliosis causes an unusual curve or curves in the spine. It makes the spine look like the letter “S” or “C” when seen from the back.
Non-Spine Conditions
Upper back pain can develop from other medical conditions that are not related to the spine. For example:
These conditions can cause individuals to move or contort into awkward positions, and swelling of muscle tissues that radiate into the upper mid-back.
Upper Back Structure
The upper back is the more stable area of the spine compared to the neck and lower back. It does not move as much because part of its main job is to protect the organs in the chest. This works in conjunction with the ribs, that is attached to the mid-back.
Because it doesn’t move as much, joint and disc problems are not as common. But that does not mean that you can’t get a herniated disc. It’s also less common to have degenerative problems in the upper mid-back.
We want you to live a life that is fulfilled with more energy, a positive attitude, better sleep, less pain, proper body weight and educated on how to maintain this way of life. I have made a life of taking care of every one of my patients.
I assure you, I will only accept the best for you.
Lower Back Pain Specialist El Paso, TX Chiropractor
Mike Melgoza is a very active person who is always engaging in physical activity, as a result, he occasionally suffers from debilitating back pain symptoms. Mr. Melgoza was struggling to sleep properly due to his symptoms of back pain before receiving chiropractic care with Dr. Jimenez.
Back pain is one of the most common reasons people visit the doctor or miss work and it is also a leading cause of disability globally. The majority of people have back pain at least once throughout their lifetimes. Luckily, you can take steps to prevent or relieve back pain.
NCBI Resources
Pain in the upper and/or mid-back is not as common as lower back or neck pain. Movement in the upper back is limited because of the attachments to the rib cage.
Upper back pain is generally caused by soft tissue injuries, like sprains or strains, muscle tension, bad posture, or looking downward for extended periods like texting, over phone use.
Neurological diseases, including well-known neurodegenerative disorders like Alzheimer’s disease (AD) and Parkinson’s disease (PD) as well as other rare health issues, such as Huntington’s disease (HD) and amyotrophic lateral sclerosis (ALS), affect millions of people worldwide. Unfortunately, these are estimated to increase due to the aging population. Currently, there is no treatment available for any neurodegenerative disorder. Treatments for symptoms are available for several neurological diseases, such as PD and HD, but the therapeutic benefits are limited. Although the causes and symptoms for these health issues are different for each neurodegenerative disorders, their molecular pathogeneses share common underlying factors and characteristics, including excessive levels of reactive oxygen species (ROS), mainly due to mitochondrial impairment, neuroinflammation, and disturbances in protein homeostasis (proteostasis). This increases the possibility of developing a universal treatment that will focus on targeting the common triggers of neurological diseases. �
Nrf2 Activation Pathways and the Human Brain
The transcription factor, Nrf2, regulates the main endogenous defense mechanism against oxidative and xenobiotic stress and inflammation. Nrf2 also plays a fundamental role in the management of mitochondrial function and cellular proteostasis, which suggests the possible benefits of Nrf2 to control neurodegenerative disorders. When under stress, Nrf2 activates the transcriptional upregulation of a large network of cytoprotective genes that allow adaptation and survival. The levels and activity of Nrf2 are controlled through ubiquitination and proteasomal degradation mediated by several ubiquitin ligase systems, including Keap1-Cul3/Rbx1, ?-TrCP-Cul1, and Hrd1. Keap1 is the most well understood key regulator of Nrf2. �
Keap1 functions as a primary sensor for electrophiles and oxidants, which chemically change certain cysteines in Keap1, leading to conformational changes that protect Nrf2 from Keap1-associated degradation. Subsequently, Nrf2 will accumulate and then translocate to the nucleus where it binds as a heterodimer with a small Maf transcription factor to antioxidant response elements in the promoter of its target genes to activate the expression of a large network of detoxification, antioxidant, and anti-inflammatory genes as well as other genes involved in the clearance of damaged proteins. Of particular interest is also the upregulation of genes responsible in the biosynthesis and the regeneration of glutathione (GSH), a major intracellular antioxidant. Moreover, Nrf2 also suppresses proinflammatory responses through transcriptional repression and it is involved in the regulation of mitochondrial function. Keap1 and p62/SQSTM1 are Nrf2-associated proteins and main regulators of negative and positive feedback loop mechanisms. In addition, p62 targets Keap1 for selective degradation through autophagy, therefore contributing to the sustained Nrf2 activation response. �
Aging has been associated with the increase in ROS and chronic inflammation, which suggests a loss of adaptability and/or impairment of Nrf2 signaling, which are particularly pronounced in age-dependent neurodegenerative disorders. Surprisingly, rare mutations in SQSTM1 can cause susceptibility to the human neurodegenerative disorder, ALS as well as frontotemporal lobar degeneration, and are associated with muted Nrf2 activation responses in clinical trials. Research studies suggest a reciprocal correlation and show negative effects of mutant disease-related proteins on Nrf2 signaling, thus suggesting the inhibition of the Nrf2 pathway as a possible mechanism underlying neurodegeneration and health issues. �
Nrf2 Activation for Neurodegenerative Disorders
ALS, an adult-onset neurodegenerative disorder caused by the selective death of motor neurons in the brain and spinal cord, is commonly characterized by progressive muscle weakness and atrophy which is generally considered to be fatal, typically within 5 years of diagnosis. ALS has a predominant sporadic ALS form with no apparent genetic component, however, approximately 5 to 10 percent of cases show an autosomal dominant inheritance pattern or familial form of the disease, known as fALS, with is known to cause gene mutations. The symptoms of sporadic ALS and familial ALS are similar, which suggests the involvement of common pathogenic mechanisms, including oxidative stress and neuroinflammation. �
Research studies show that oxidative stress and neuroinflammation should be the key therapeutic targets of Nrf2 signaling in ALS. Genetic research studies in ALS mouse models have shown a considerable therapeutic effect of increased Nrf2 levels in astrocytes, the main GSH producers for neurons. Furthermore, Nrf2 signaling is fundamental for controlling neuroinflammation in ALS through the management of the effects of activated microglial cells on overall neuronal survival. Consistent with the therapeutic potential of Nrf2 signaling, treatment with small molecule activators, including the extremely potent cyanoenone triterpenoids, has ultimately shown efficacy in research study mouse ALS models. �
The neuroprotective potential of Nrf2 activation has been evaluated in experiments utilizing genetic mouse HD models. HD is an autosomal dominant and highly penetrant neurodegenerative disorder, which results from the pathological expansion of a trinucleotide CAG repeats encoding polyglutamines in HTT protein. Brains from patients with HD usually show marked striatal and cortical atrophy at the time of diagnosis. Once motor or other symptoms become apparent, generally throughout midlife, the affected individuals become increasingly disabled over the course of 15 to 25 years before eventually succumbing to the effects of severe physical and mental deterioration, according to evidence from research studies. �
Complex pathogenic mechanisms have been shown in HD, however, excessive oxidative stress has been recognized as a fundamental driver of pathology. The harmful role of oxidative stress has been described in both HD patients and in experimental clinical trial models and it is potentially due to the neuronal sensitivity of an excess in ROS. The levels of several Nrf2-dependent antioxidant proteins, including glutathione peroxidases, catalase, and superoxide dismutase 1, are increased in human HD brains as compared with non-disease controls, suggesting a partial activation of Nrf2 defense signaling yet insufficient enough to block progressive neurodegeneration. Pharmacological activation of Nrf2 results in the broad antioxidant effects of HD in mouse brains and ameliorates the neurological phenotype. Increased expression of several key inflammatory mediators has been shown in the blood, the striatum, the cortex, and the cerebellum from postmortem patient HD tissues, however, neuroinflammation in HD patients seems to be less pronounced than in ALS or PD patients. �
Neurological Disease Treatment with Nrf2 Activation
Finally, the neurological phenotype of the most common neurological disease and neurodegenerative disorder, PD, can be challenged by Nrf2 activation. PD is characterized by the progressive loss of dopaminergic neurons in the substantia nigra and the profound reduction of dopamine in the striatum. Currently available dopaminergic treatments offer relief from several symptoms but these only address the motor manifestations. Multiple genetic and environmental factors have been suggested in the etiology of PD, however, like ALS, the majority of the clinical cases are sporadic. The discovery that the environmental neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes Parkinson’s disease in humans, led to the development of the MPTP mouse model of disease, which to date, remains one of the most highly utilized animal models of sporadic PD, including the evaluation of drug efficiency. Nrf2 activators showed neuroprotective effects in MPTP mice, which are associated with a reduction of oxidative damage and neuroinflammation. The identification of causative mutations in SNCA, the gene encoding ?-synuclein (aSyn), developed genetic mouse PD models, in which daily oral delivery of the Nrf2 activator dimethyl fumarate (DMF) protected nigral dopaminergic neurons against aSyn toxicity. �
Although oxidative stress and neuroinflammation are pathological hallmarks of AD, a therapeutic role of Nrf2 signaling has developed more slowly, perhaps due to the complexity of disease pathogenesis and readouts of efficiency. Nonetheless, there is a number of recent research studies that demonstrate the efficiency of Nrf2 activators in AD mouse models. � DMF, a U.S. FDA-approved drug (Tecfidera, Biogen-Idec) for the treatment of relapsing multiple sclerosis, activates Nrf2 through the regulation of the Keap1 sensor. DMF is of seemingly low potency and specificity, which prevents neurodegeneration. Drug-like molecules with a similar mechanism of action or with the ability of direct interference with the Keap1/Nrf2 interaction are emerging. The data demonstrate the feasibility to develop Nrf2 activators for treatment. �
In summary, although the causes and symptoms of neurological diseases are different, neurodegenerative disorders share similar molecular mechanisms, which could be regulated and managed with Nrf2 activators. Moreover, targeting Nrf2 signaling may offer a safe and effective treatment approach for a variety of these health issues. Because pharmacological Nrf2 activation targets the broad mechanisms of these health issues, all neurodegenerative conditions would be eligible for treatment. Furthermore, the main goal is to develop noninvasive oral treatment(s) for patients under the supervision of healthcare professionals, which targets both sporadic and familial patients. – Dr. Alex Jimenez D.C., C.C.S.T. Insight
Neurotransmitter Assessment Form
The following Neurotransmitter Assessment Form can be filled out and presented to Dr. Alex Jimenez. Symptoms listed on this form are not intended to be utilized as a diagnosis of any type of disease, condition, or any other type of health issue. �
Neurological diseases, including well-known neurodegenerative disorders like Alzheimer’s disease (AD) and Parkinson’s disease (PD) as well as other rare health issues, such as Huntington’s disease (HD) and amyotrophic lateral sclerosis (ALS), affect millions of people worldwide. Unfortunately, these are estimated to increase due to the aging population. Currently, there is no treatment available for any neurodegenerative disorder. Treatments for symptoms are available for several neurological diseases, such as PD and HD, but the therapeutic benefits are limited. Although the causes and symptoms for these health issues are different for each neurodegenerative disorders, their molecular pathogeneses share common underlying factors and characteristics, including excessive levels of reactive oxygen species (ROS), mainly due to mitochondrial impairment, neuroinflammation, and disturbances in protein homeostasis (proteostasis). This increases the possibility of developing a universal treatment that will focus on targeting the common triggers of neurological diseases. �
The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 . �
Curated by Dr. Alex Jimenez �
References: �
Dinkova-Kostova, Albena T, et al. �Activation of Nrf2 Signaling as a Common Treatment of Neurodegenerative Diseases.� Activation of Nrf2 Signaling as a Common Treatment of Neurodegenerative Diseases | Neurodegenerative Disease Management, 23 May 2017, www.futuremedicine.com/doi/full/10.2217/nmt-2017-0011#.
Additional Topic Discussion: Chronic Pain
Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals, however, chronic pain is different than the average type of pain. With chronic pain, the human body will continue sending pain signals to the brain, regardless if the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient’s mobility and it can reduce flexibility, strength, and endurance.
Neural Zoomer Plus for Neurological Disease
�
Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual�s reactivity to 48 neurological antigens with connections to a variety of neurologically related diseases. The Vibrant Neural ZoomerTM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention. �
Food Sensitivity for the IgG & IgA Immune Response
�
Dr. Alex Jimenez utilizes a series of tests to help evaluate health issues associated with food sensitivities. The Food Sensitivity ZoomerTM is an array of 180 commonly consumed food antigens that offers very specific antibody-to-antigen recognition. This panel measures an individual�s IgG and IgA sensitivity to food antigens. Being able to test IgA antibodies provides additional information to foods that may be causing mucosal damage. Additionally, this test is ideal for patients who might be suffering from delayed reactions to certain foods. Utilizing an antibody-based food sensitivity test can help prioritize the necessary foods to eliminate and create a customized diet plan around the patient�s specific needs. �
Formulas for Methylation Support
XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly,�Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic�Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
�
For your convenience and review of the XYMOGEN products please review the following link. *XYMOGEN-Catalog-Download �
* All of the above XYMOGEN policies remain strictly in force.
IFM's Find A Practitioner tool is the largest referral network in Functional Medicine, created to help patients locate Functional Medicine practitioners anywhere in the world. IFM Certified Practitioners are listed first in the search results, given their extensive education in Functional Medicine
