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The Gut-Liver Connection

The Gut-Liver Connection

Do you feel:

  • Hormone imbalances?
  • Excessively foul-smelling sweat?
  • Excessive belching, burping, or bloating?
  • Digestive problems subside with relaxation?
  • Difficult bowel movement?

If you are experiencing any of these situations, then you might be experiencing some gut and liver issues in your body.

The role of the gut-liver axis in NAFLD (non-alcoholic fatty liver disease) has been examining probiotics and have found some new information on the gut microbiome and how probiotics work in NAFLD. The new information that future research found was quite interesting. It stated that there were about 26 major randomized controlled trials that used probiotics for NALFD that ranged between 20 to 200 individuals in four weeks to 1 year. The laboratory assessments included liver enzymes and anthropometric parameters in the body. Some of the studies added cardiovascular risk factors like C-reactive proteins and lipid profiles as markers for insulin resistance. Furthermore, most of the studies have used a probiotic formulation that includes multiple species, although a few were conducted by using a single strain.

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What NAFLD does to the body is that it becomes a hepatic consequence of metabolic syndrome. This includes obesity, diabetes, and dyslipidemia. What is interesting about the connection between gut microbiota and NAFLD has been attracting a significant amount of attention in recent years. The data has shown that the gut microbiota can affect the hepatic lipid metabolism while also influencing the balance between pro/anti-inflammatory effectors in the liver.

Chronic Liver Diseases

Even though chronic liver disease is the primary cause of morbidity and mortality worldwide. Studies showed that gut dysbiosis was identified as an essential factor in the pathogenesis of the liver disease. The relationship between the gut microbiota and the liver is still not understood, but the dysfunction of leaky gut and an increased bacterial translocation into the liver. Another study showed that immense importance is a massive advancement in understanding the roles of the gut and liver microbiome that is driven by a high DNA sequencing and improving them.

There are many stages of liver disease that can happen, but when it comes to excessive alcohol in the liver. Studies show that excessive alcohol consumption is the leading cause of chronic liver disease worldwide. The stages of alcoholic liver disease are hepatic steatosis, steatohepatitis, and, ultimately, liver cirrhosis. One of the main characteristics of alcohol liver disease is that there is an increased gut permeability due to a direct toxic effect of alcohol on the epithelial cell in the gastrointestinal tract and a decreases expression of the tight-junction protein.

Probiotic Supplements

For probiotic supplementation, they have demonstrated a significant decrease in liver enzymes, which were compared to the placebo group. Studies found that probiotics were shown to have synergistic effects with metformin on liver enzymes for patients that have NASH. Any products that contained both prebiotics and probiotics can demonstrate a similar effect in the probiotic groups. In another study, it showed a reduction of intrahepatic fat that is measured by MRI, but the improvement in liver enzymes in the body did not reach any clinical significance. It is essential to know that liver enzymes can have a highly variable and do not always have a direct correlation with disease progression that they may encounter.

Research shows that there are five meta-analyses included and that they all demonstrated that probiotics and synbiotics have improved on AST and ALT levels in the body significantly. Surprisingly, several other studies have assisted probiotics by countering hepatic steatosis, fibrosis, and liver stiffness in the body. Ultrasound imaging can help assist these parameters and show some positive clinical outcomes with these two supplements.

When probiotics help restore the gastrointestinal barrier function in the body, they can eliminate the harmful bacteria that has interacted with the gastrointestinal system. Not only that, but probiotics can also be beneficial by modulating the immune system, reduce liver fats, and improve the liver enzymes as well. By using probiotics, they are most likely to be more productive by helping the body and preventing bacterial translocation in the gut, thus reducing the effects of the intestinal microbiota on the liver to prevent chronic illnesses from forming and causing havoc.

Conclusion

For individuals that have NAFLD, they will already establish the disease and required a higher nutrient intake demand than what can be obtained from any diets alone. So using dietary supplements should be considered to help reduce the NAFLD disease’s progression, thus improving the liver and its functions. The gut-liver axis is connected to the body since if anything happens to the liver like chronic diseases, it can affect the gut as well. Using probiotics to help the liver is essential to make sure that the liver is functioning correctly and that the body is being as healthy as possible. Some products are here to offer gastrointestinal and metabolic support while also supporting multiple aspects of the biliary system.

The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.


References:

Jurgelewicz, Michael. �New Review Demonstrates the Role of the Gut Microbiome and Probiotics in Nonalcoholic Fatty Liver Disease.� Designs for Health, 25 Nov. 2019, blog.designsforhealth.com/node/1160.

Konturek, Peter Christopher, et al. �Gut?Liver Axis: How Do Gut Bacteria Influence the Liver?� Medical Sciences (Basel, Switzerland), MDPI, 17 Sept. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6165386/.

Tripathi, Anupriya, et al. �The Gut-Liver Axis and the Intersection with the Microbiome.� Nature Reviews. Gastroenterology & Hepatology, U.S. National Library of Medicine, July 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6319369/.

Xie, Chencheng, and Dina Halegoua DeMarzio. “Role of Probiotics in Nonalcoholic Fatty Liver Disease: Does Gut Microbiota Matter?” MDPI, Multidisciplinary Digital Publishing Institute, 19 Nov. 2019, www.mdpi.com/2072-6643/11/11/2837.

 

5 Ways to Have a Healthy Liver El Paso, Texas

5 Ways to Have a Healthy Liver El Paso, Texas

Ah� the bathroom, nature�s thinking room. The one place where we create many thoughts that turn into ideas, a place to read, and the place where we want peace and quiet. Known as many different names,� the bathroom is the one place where we flush out our systems after consuming quantities of food. However, did you know that the bile inside your body plays a huge important role in our system?

11860 Vista Del Sol, Ste. 128 5 Ways to Have a Healthy Liver El Paso, Texas

Bile is a vital body fluid that absorbs nutrients in our small intestines and flushes the toxins out of the liver. Bile continuously is being produced in the liver and then stored in the gallbladder. It also works as a signal molecule for both inside and outside the liver as well. When the liver and bile is disruptive, it can cause many problems for the body.

 

TCM (Traditional Chinese Medicine) stated that the liver is known as the �master organ� and it is the causative factor in many of the body�s ailments. When there are major imbalances on our bodies, it causes liver dysfunction. In TCM, the liver actually helps with detoxification; enzyme, hormone, and bile production, immune cell activation and stores vitamins and iron.

 

How Does the Liver Work?

The liver�s main job is to get rid of bile in our internal system. Not only that but the liver plays an important role by distributing nutrients by converting those nutrients into metabolizing energy. As well as storing vitamins and minerals for later use.

11860 Vista Del Sol, Ste. 128 5 Ways to Have a Healthy Liver El Paso, Texas

 

However, in today�s fast-paced society, the liver can�t perform right as we don�t give the liver it�s essential nutrients that it needs to function. Which causes blockage in the gallbladder, diseases, and digestive issues.

 

The Importance of Bile

As stated, bile has many functions that play an important part in the liver. Bile actually lubricates our small intestines and stool for easy disposal. But when there is less lubrication in our small intestines and stool, it can lead to constipation and too much lubrication can lead to diarrhea.

 

There is also a chance of blockage in bile where it can increase the accumulation of toxins in our body which creates oxidative stress and back up our waste matter. When we eat too much food and it�s still in our intestines, it will ferment and causes a leaky gut as toxic gasses penetrate the intestinal lining.

 

Another function is that the bile salts break down and processes fats that are essential for weight loss. Bile can also transport toxins out of our liver to feces while keeping everything free-flowing. When there isn�t enough bile being produced, cholesterol stones are forming.

 

Vitamins like, vitamin A, D, E and K can break down the excess fat in the body if there is an adequate amount of bile. But if patients had gallbladder surgery must be taken to account that they don�t have a bile storage system, and must manage their bile production.

 

Liver Functions for Hormonal Balance

Did you know that the liver and thyroid have a synergistic relationship? That�s because the T4 is converted to T3 for the liver. It turns out that the T3 is more potent in the thyroid hormone and is metabolized from iodine. When a patient has a thyroid problem, it could actually be the result of a bile or liver malfunction.

 

When our mood and mental state is imbalanced, it can be the results of a sick or fatty liver. Due to the fact that the liver influencing on our hormones. Because our mental state and our moods correlate to our hormones, it is important to keep the liver healthy but also finding a good place in our state of mind to make sure that we keep our liver healthy as well.

 

Signs of Liver Imbalance

There are many symptoms that can cause the liver to be imbalanced and can contribute to a low bile count:

  • Constipation, bloating, gas
  • Leaky gut
  • Fatigue
  • Weight gain
  • Irregular stool
  • High cholesterol
  • Tendon problems

Ways to Support the Liver and Produce More Bile

Now that we understand what symptoms that causes our liver to be imbalanced, here are 5 ways to make sure that you are protecting your liver and producing a healthy amount of bile.

  1. Removing Causative Factors

The first and foremost factor in protecting your liver is to get rid of the causative factors that are harming your liver. Things like an excessive amount of lactate in coffee, sugars, alcohol, and processed foods can disrupt your liver�s health. It�s ok to enjoy those things sparsely but, if you are trying to maintain a healthy liver, it�s best to ease up on the consumption of those lactate factors as much as possible.

  1. Eating Liver Supportive Foods

There are many foods that actually help support the liver. Grapefruit, blueberries, cranberries, prickly pears, and bitter greens are just some of the foods that can actually help your liver and bile production. We here at Injury Medical Clinic, always inform our patients the importance of whole nutritious food to heal and repair what ailments in our patient�s bodies.

  1. Practicing Deep Breathing Exercise

Practicing deep breathing exercises have been known to lower stress and diaphragmatic breathing exercises is no exception. Since the liver is positioned below the diaphragm, when we do any deep breathing exercises; these motions actually massages our liver and stimulate bile production. Hence why singers do these exercises when they are getting ready to perform. They are massaging their liver without even knowing it.

  1. Intermittent Fasting

Since we now know that bile is continuously being produced in the liver and being stored into the gallbladder when we are not eating, intermittent fasting is a good way to increase the bile production in the gallbladder. Plus it has been known for weight loss and beneficial for the body to heal while getting rid of the junk in our cells.

  1. Stress Less

Stress is one of the huge factors that can either cause our body to improve our immune system or causes the body to chronic illness. Emotional stress is known to cause a huge burden to our organs because it is tied to our hormones. When we get emotionally stressed, our liver cannot get rid of the excess toxins and hormones.� So we have to find ways to de-stressed ourselves so we won�t hurt our organs, especially the liver.

Conclusion

So when it comes to our liver, we must make sure that the bile that we are producing is turning into energy all the way to feces. So, when we have to go to the bathroom we can let out the toxins naturally without any complications. If we can lower the factors that are causing us to have an inadequate bowel movements, then we can improve our body�s ability to detoxify.


 

NCBI Resources

Western diets, high in sugar and fat, cause liver inflammation, especially in males, according to a new animal study in�The American Journal of Pathology. Inflammation was most pronounced in males that lacked farnesoid x receptor (FXR), a bile acid receptor.