by Dr Alex Jimenez DC, APRN, FNP-BC, CFMP, IFMCP | Functional Medicine, Gut and Intestinal Health, Health, Nutrition
Do you feel:
- Hormone imbalances?
- Excessively foul-smelling sweat?
- Excessive belching, burping, or bloating?
- Digestive problems subside with relaxation?
- Difficult bowel movement?
If you are experiencing any of these situations, then you might be experiencing some gut and liver issues in your body.
The role of the gut-liver axis in NAFLD (non-alcoholic fatty liver disease) has been examining probiotics and have found some new information on the gut microbiome and how probiotics work in NAFLD. The new information that future research found was quite interesting. It stated that there were about 26 major randomized controlled trials that used probiotics for NALFD that ranged between 20 to 200 individuals in four weeks to 1 year. The laboratory assessments included liver enzymes and anthropometric parameters in the body. Some of the studies added cardiovascular risk factors like C-reactive proteins and lipid profiles as markers for insulin resistance. Furthermore, most of the studies have used a probiotic formulation that includes multiple species, although a few were conducted by using a single strain.
What NAFLD does to the body is that it becomes a hepatic consequence of metabolic syndrome. This includes obesity, diabetes, and dyslipidemia. What is interesting about the connection between gut microbiota and NAFLD has been attracting a significant amount of attention in recent years. The data has shown that the gut microbiota can affect the hepatic lipid metabolism while also influencing the balance between pro/anti-inflammatory effectors in the liver.
Chronic Liver Diseases
Even though chronic liver disease is the primary cause of morbidity and mortality worldwide. Studies showed that gut dysbiosis was identified as an essential factor in the pathogenesis of the liver disease. The relationship between the gut microbiota and the liver is still not understood, but the dysfunction of leaky gut and an increased bacterial translocation into the liver. Another study showed that immense importance is a massive advancement in understanding the roles of the gut and liver microbiome that is driven by a high DNA sequencing and improving them.
There are many stages of liver disease that can happen, but when it comes to excessive alcohol in the liver. Studies show that excessive alcohol consumption is the leading cause of chronic liver disease worldwide. The stages of alcoholic liver disease are hepatic steatosis, steatohepatitis, and, ultimately, liver cirrhosis. One of the main characteristics of alcohol liver disease is that there is an increased gut permeability due to a direct toxic effect of alcohol on the epithelial cell in the gastrointestinal tract and a decreases expression of the tight-junction protein.
Probiotic Supplements
For probiotic supplementation, they have demonstrated a significant decrease in liver enzymes, which were compared to the placebo group. Studies found that probiotics were shown to have synergistic effects with metformin on liver enzymes for patients that have NASH. Any products that contained both prebiotics and probiotics can demonstrate a similar effect in the probiotic groups. In another study, it showed a reduction of intrahepatic fat that is measured by MRI, but the improvement in liver enzymes in the body did not reach any clinical significance. It is essential to know that liver enzymes can have a highly variable and do not always have a direct correlation with disease progression that they may encounter.
Research shows that there are five meta-analyses included and that they all demonstrated that probiotics and synbiotics have improved on AST and ALT levels in the body significantly. Surprisingly, several other studies have assisted probiotics by countering hepatic steatosis, fibrosis, and liver stiffness in the body. Ultrasound imaging can help assist these parameters and show some positive clinical outcomes with these two supplements.
When probiotics help restore the gastrointestinal barrier function in the body, they can eliminate the harmful bacteria that has interacted with the gastrointestinal system. Not only that, but probiotics can also be beneficial by modulating the immune system, reduce liver fats, and improve the liver enzymes as well. By using probiotics, they are most likely to be more productive by helping the body and preventing bacterial translocation in the gut, thus reducing the effects of the intestinal microbiota on the liver to prevent chronic illnesses from forming and causing havoc.
Conclusion
For individuals that have NAFLD, they will already establish the disease and required a higher nutrient intake demand than what can be obtained from any diets alone. So using dietary supplements should be considered to help reduce the NAFLD disease’s progression, thus improving the liver and its functions. The gut-liver axis is connected to the body since if anything happens to the liver like chronic diseases, it can affect the gut as well. Using probiotics to help the liver is essential to make sure that the liver is functioning correctly and that the body is being as healthy as possible. Some products are here to offer gastrointestinal and metabolic support while also supporting multiple aspects of the biliary system.
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.
References:
Jurgelewicz, Michael. �New Review Demonstrates the Role of the Gut Microbiome and Probiotics in Nonalcoholic Fatty Liver Disease.� Designs for Health, 25 Nov. 2019, blog.designsforhealth.com/node/1160.
Konturek, Peter Christopher, et al. �Gut?Liver Axis: How Do Gut Bacteria Influence the Liver?� Medical Sciences (Basel, Switzerland), MDPI, 17 Sept. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6165386/.
Tripathi, Anupriya, et al. �The Gut-Liver Axis and the Intersection with the Microbiome.� Nature Reviews. Gastroenterology & Hepatology, U.S. National Library of Medicine, July 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6319369/.
Xie, Chencheng, and Dina Halegoua DeMarzio. “Role of Probiotics in Nonalcoholic Fatty Liver Disease: Does Gut Microbiota Matter?” MDPI, Multidisciplinary Digital Publishing Institute, 19 Nov. 2019, www.mdpi.com/2072-6643/11/11/2837.
by Dr Alex Jimenez DC, APRN, FNP-BC, CFMP, IFMCP | Functional Medicine, Gastro Intestinal Health, Health, Nutrition
Do you feel:
- Inflammation in your gut system?
- Edema and swelling in ankles and wrist?
- Stomach pain?
- Digestive problems subside with relaxation?
- Inflammation in your joints?
If you are experiencing any of these situations, then you might have pain and inflammation in your body. Here are some ways to help naturally ease the pain in your body.
There is some evidence the conventional go-to pain relievers and anti-inflammatory medicine can help by delivering their benefits along with a host of potentially dangerous effects to anyone. Both medical professionals and patients are looking for alternative medicines that have the same effects as pharmaceutical medicine but that are safe and more effective. Fortunately, numerous natural compounds are backed up by clinical research and studies that are available to help anyone that have a variety of issues that are caused by pain and inflammation.
Factors Involving Inflammation
Research from the Cleveland Clinic had warned patients that NSAIDs (nonsteroidal anti-inflammatory drugs) are intended for short-term use. That person should never use it continuously for fever for more than three days and at least ten days for pain without the consultant from a healthcare provider. Studies show that for any fish oils or other sources of long-chain omega-3 fatty acids that have the same effect since it is the precursor to anti-inflammatory prostaglandins and resolvins for the body.
Natural Products for Inflammation
If there is a long-term consumption food that is high in EPA and DHA that are dangerous, there will be a substantial fish-eating population in East Asia and Scandinavia; then, there would be a considerable problem long ago. This, however, is the opposite of what epidemiological studies found since fish consumption is beneficial for the person’s health and improving the biomarker for cardiovascular risk. For anyone that is allergic to fish, eggs, flaxseeds, and it is oil or algal oil is a rich source of omega-3s for the body.
There are other various foods and herbal extracts that been shown to be beneficial in managing pain and inflammation. One of them is ginger. Ginger has been used for a long time as a remedy for upset stomach and indigestion, while also being effective for reducing menstrual cycle pain like NSAIDs. Studies show the herb Boswellia can reduce the pain and stiffness that are associated with osteo- and rheumatoid arthritis and one of the mechanics that are responsible for the body that inhibits the inflammatory 5-LOX (5-lipoxygenase).
What is interesting about Boswellia is that studies show that the herb is different from NSAIDs because NSAIDs may induce potential life-threating GI tract bleeding. The evidence shows that the Boswellia herb can improve inflammatory conditions in the gastrointestinal tract, like chronic colitis. There are more natural compounds that are the potential to ease pain and inflammation like cannabis. With the expanding legalization throughout the US, medicinal and recreational cannabis can help many people deal with their pain with this impressive plant.
Incorporating Changes To Stop Inflammation
Besides incorporating these natural herbs and anti-inflammatory foods into a person�s diet to help alleviate pain and inflammation, no one should neglect the non-diet strategies. Changing food and supplements are not the only changes when a person is seeking alternatives. A past article started to explore how laughter, positive thinking, and maintaining physical activity has the potential to manage chronic pain that the body may encounter. Even though the old saying states that “laughter is the best medicine,” the old saying is contradicted now and days. Even though laughter is not the best medicine, but laughter can undoubtedly be a form of medicine.
Another way a person can reduce or resolve inflammation is by their diet. This can affect what a person does not eat than what they do eat. Studies show that ketogenic diets, which are high in fats and very low in carbohydrates, have been known to increase pain tolerance and reduce acute inflammation. The results were astounding as patients with type 2 diabetes following a ketogenic diet for one year, experienced a 39% reduction in hsCRP, which is a massive indicator for inflammation. Another research study observed patients who followed a ketogenic diet for two years, had a 37% reduction from their baseline.
More research studies show that patients that have metabolic syndrome and follow a carbohydrate-restricted Paleolithic diet for four weeks have experienced a 39% reduction in their hsCRP as well as 35% and 29% reduction in their TNF-a and IL-6. When low-carb Paleo diets are combined with intensity exercises can help improve the body by dampening the inflammatory markers significantly.
Conclusion
For anyone that is living with inflammation in their body, using pharmaceutical medicines is not always the answer. Combining a carb-restricted diet and other natural interventions can help with inflammation. By making small changes for the body, the chronic pain and inflammation can be reduced, thus the body can start healing naturally. Some products are designed to help relax the tight muscles in the body to prevent inflammation while also helping the body to relax and provide a better night’s sleep.
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.
References:
Alhassan, Abeer, et al. �Consumption of Fish and Vascular Risk Factors: A Systematic Review and Meta-Analysis of Intervention Studies.� Atherosclerosis, US National Library of Medicine, Nov. 2017, www.ncbi.nlm.nih.gov/pubmed/28992469.
Ammon, H P T. �Boswellic Acids in Chronic Inflammatory Diseases.� Planta Medica, US National Library of Medicine, Oct. 2006, www.ncbi.nlm.nih.gov/pubmed/17024588.
Athinarayanan, Shaminie J, et al. �Long-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-Year Non-Randomized Clinical Trial.� Frontiers in Endocrinology, Frontiers Media SA, 5 June 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6561315/.
Bhanpuri, Nasir H, et al. �Cardiovascular Disease Risk Factor Responses to a Type 2 Diabetes Care Model Including Nutritional Ketosis Induced by Sustained Carbohydrate Restriction at 1�Year: an Open Label, Non-Randomized, Controlled Study.� Cardiovascular Diabetology, BioMed Central, 1 May 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC5928595/.
Calder, Philip C. �Omega-3 Fatty Acids and Inflammatory Processes.� Nutrients, Molecular Diversity Preservation International, Mar. 2010, www.ncbi.nlm.nih.gov/pmc/articles/PMC3257651/.
Commissioner, Office of the. �The Benefits and Risks of Pain Relievers: Q & A on NSAIDs.� US Food and Drug Administration, FDA, 24 Sept. 2015, www.fda.gov/consumers/consumer-updates/benefits-and-risks-pain-relievers-q-nsaids-sharon-hertz-md.
Drug Evaluation and Research, Center for. �FDA Drug Safety Communication.� US Food and Drug Administration, FDA, 9 July 2015, www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-strengthens-warning-non-aspirin-nonsteroidal-anti-inflammatory.
Gupta, I, et al. �Effects of Gum Resin of Boswellia Serrata in Patients with Chronic Colitis.� Planta Medica, US National Library of Medicine, July 2001, www.ncbi.nlm.nih.gov/pubmed/11488449.
Gyorkos, Amy, et al. �Carbohydrate-Restricted Diet and High-Intensity Interval Training Exercise Improve Cardio-Metabolic and Inflammatory Profiles in Metabolic Syndrome: A Randomized Crossover Trial.� Cureus, Cureus, 8 Sept. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6822889/.
Hosomi, Ryota, et al. �Seafood Consumption and Components for Health.� Global Journal of Health Science, Canadian Center of Science and Education, 28 Apr. 2012, www.ncbi.nlm.nih.gov/pmc/articles/PMC4776937/.
Masino, Susan A, and David N Ruskin. �Ketogenic Diets and Pain.� Journal of Child Neurology, US National Library of Medicine, Aug. 2013, www.ncbi.nlm.nih.gov/pmc/articles/PMC4124736/.
Nandivada, Prathima, et al. �Eucaloric Ketogenic Diet Reduces Hypoglycemia and Inflammation in Mice with Endotoxemia.� Lipids, US National Library of Medicine, June 2016, www.ncbi.nlm.nih.gov/pubmed/27117864.
Team, Cleveland Clinic. �NSAIDs: What You Need to Know.� Cleveland Clinic, 2016, my.clevelandclinic.org/health/drugs/11086-non-steroidal-anti-inflammatory-medicines-nsaids.
Team, DFH. �3 Non-Pharmacological Daily Practices for Managing Pain.� Designs for Health, 1 Feb. 2019, blog.designsforhealth.com/node/942.
Team, DFH. �Ease Pain Naturally.� Designs for Health, 25 Nov. 2019, blog.designsforhealth.com/node/1158.
Team, DFH. �Ginger � as Effective as NSAIDs for Menstrual Pain.� Designs for Health, 5 Jan. 2018, blog.designsforhealth.com/ginger-as-effective-as-nsaids-for-menstrual-pain.
by Dr Alex Jimenez DC, APRN, FNP-BC, CFMP, IFMCP | Functional Medicine, Health, Herbs, Nutrition, Wellness
Do you feel:
- Unpredictable abdominal swelling?
- Hormone imbalance?
- Occasional stress?
- Inflammation in the gut?
- Weight gain?
If you are experiencing any of these situations, then why not try these botanical herbs in your food dish.
The holiday season brings out the joy out of people with holiday traditions and its unique, universal foods, drinks, seasonal herbs, and spices to the table. The colder seasons are where everyone in the U.S. indulges in hearty soups, pumpkin spice products, root vegetables, and turkey leftovers. Many holiday menu items will incorporate sweet and savory herbs and spices in their food dishes. What people do not realize is that even though these herbs and spices enhance the flavors of the food, they also provide a plethora of health benefits for the body. So using these herbs and spices in the kitchen can help increase the person’s chances to receive their beneficial properties, hence “the more, the merrier.”
Throughout the centuries, medicinal plants have been traditionally used by a variety of cultures. Some of nature’s most potent herbs are most used in culinary dishes, while also providing the beneficial properties to the human body; they are rosemary, sage, and clove.
Rosemary
Being commonly used as a condiment and a food preservative, rosemary is a native herb in the Mediterranean region. A review did an animal study of in vivo and in vitro that showed that rosemary had demonstrated similar beneficial effects to any medications that are for a variety of physiological disorders. Some of the physiological disorders include:
- Lead hepato-nephrotoxicity
- Stress
- Anxiety
- Bodyweight and dyslipidemia
- Pain
- Cerebral ischemia
Another review was looking at how rosemary has antimicrobial and antioxidant properties and that its abundance in isoprenoid quinones. The review stated that rosemary could �act as chain terminators for free radicals and as chelators for ROS (reactive oxygen species.)” The antioxidative properties in rosemary have about the majority of phenolic diterpenes; like carnosic acid and carnosol, that are responsible for about 90% of this herb. Since it inhibits lipid peroxidation, scavenge radicals, and helps reduce cytochrome c by activating the redox-dependent signaling pathways in the body.
With carnosic acid, it has been shown to provide superior antimicrobial actions to other significant constituents that are found in rosemary. Furthermore, there have been studies shown that rosemary has antibacterial effectiveness against resistant bacteria in the body.
Sage
Sage is another herb that is native to the Mediterranean and Middle East regions and has been used in traditional folk medicine to treat a variety of disorders in the body. There is recent research that has suggested that sage can possess a wide range of beneficial properties for the body due to the presence of carnosic acid and carnosol in this herb. Another study showed that sage contains high contents of glycosidic flavones that provide functional inhibitory capacity against xanthine oxidase activity in the body. Some of the beneficial properties include:
- Anti-inflammatory
- Antinociceptive
- Antibacterial
- Hypoglycemic
- Antioxidative
There is further research that demonstrates how sage has powerful cognitive enhancing and neuroprotective properties. Studies show that patients with Alzheimer�s disease took a 4-month supplementation of sage, and the results are remarkable. Alzheimer patients experienced significant improvements in their cognitive function and mood enhancements. In another study, sage extract can help reduce the severity of physical and psychological systems that are experienced in premenstrual syndrome in the body. A recent article showed how freshly harvested sage leaves can become a potent modulator for neuroreceptor pathways that involves serotonin transporters that may help normalize thermoregulation and mental impairment for menopausal women.
Surprisingly though, both rosemary and sage have been proven and shown that they can help improve gabaergic pathways in the brain and can help decrease the neuronal activities that are associated with anxiety disorders. Studies show that rosemary and sage extracts have hepatoprotective and antioxidative roles that can increase catalase and glutathione levels and decrease lipid peroxidation in the body.
Cloves
Clove buds were initially found in east Indonesia, and it plays a role as the herb has a potent antimicrobial and antioxidative botanical. Research shows that clove oil possesses a bactericidal effect against pathogenic species that can harm the body. Earlier this year, a research study found out that clove oil extract can enhance anti-inflammatory activity by reducing myeloperoxidase activity in human neutrophils significantly. This herb can help reduce ROS and a variety of other inflammatory mediators that can promote significant damage to the body at the site of inflammation.
Conclusion
So for the holidays, adding these three powerful herbs to the next holiday feast are not just there to help enhance the flavors of the dishes, but they are beneficial to the body. Since they provide anti-inflammatory properties to the body by decreasing the inflammatory responses. So for the colder seasons, add that extra dash of herbs into the dish recipe will make anyone’s day merry. Some products are specialized in countering the metabolic effects of temporary stress and can support the body.
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.
References:
Chniguir, Amina, et al. �Syzygium Aromaticum Aqueous Extract Inhibits Human Neutrophils Myeloperoxidase and Protects Mice from LPS-Induced Lung Inflammation.� Pharmaceutical Biology, Taylor & Francis, Dec. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6366422/#!po=2.63158.
Choukairi, Zineb, et al. �Effect of Salvia Officinalis L. and Rosmarinus Officinalis L. Leaves Extracts on Anxiety and Neural Activity.� Bioinformation, Biomedical Informatics, 15 Mar. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6637401/.
de Oliveira, Jonatas Rafael, et al. �Rosmarinus Officinalis L. (Rosemary) as Therapeutic and Prophylactic Agent.� Journal of Biomedical Science, BioMed Central, 9 Jan. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6325740/.
Lopresti, Adrian L. �Salvia (Sage): A Review of Its Potential Cognitive-Enhancing and Protective Effects.� Drugs in R&D, Springer International Publishing, Mar. 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5318325/.
Nieto, Gema, et al. �Antioxidant and Antimicrobial Properties of Rosemary (Rosmarinus Officinalis, L.): A Review.� Medicines (Basel, Switzerland), MDPI, 4 Sept. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6165352/.
Pavi?, Valentina, et al. �Extraction of Carnosic Acid and Carnosol from Sage (Salvia Officinalis L.) Leaves by Supercritical Fluid Extraction and Their Antioxidant and Antibacterial Activity.� Plants (Basel, Switzerland), MDPI, 9 Jan. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6359053/.
Pereira, Ol�via R, et al. �Salvia Elegans, Salvia Greggii and Salvia Officinalis Decoctions: Antioxidant Activities and Inhibition of Carbohydrate and Lipid Metabolic Enzymes.� Molecules (Basel, Switzerland), MDPI, 1 Dec. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6321363/.
Team, DFH. �Spice Up the Holidays with Medicinal Botanicals.� Designs for Health, 25 Nov. 2019, blog.designsforhealth.com/node/1156.
Tober, Carsten, and Roland Schoop. �Modulation of Neurological Pathways by Salvia Officinalis and Its Dependence on Manufacturing Process and Plant Parts Used.� BMC Complementary and Alternative Medicine, BioMed Central, 13 June 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6567565/.
by Dr Alex Jimenez DC, APRN, FNP-BC, CFMP, IFMCP | Chiropractic
As doctor Mark Hyman says, “Food is medicine. You can not find anything in a bottle that is more powerful than what you put on your fork”. The best diet for pain relief depends on the individual but ultimately comes down to reducing inflammation and restoring the healthy bacteria in the gut.
Methylation Diet
Methylation is a natural process in the body that controls the replication of DNA. In turn, methylation is responsible for the aging of each cell and has been thought to play a role in the onset of, or a lack of, chronic disease.� Methylation is also responsible to control the unhealthy compound that can damage blood vessels called homocysteine, recycles molecules for optimal detoxification and keeps inflammation under control. The methylation diet focuses around adding foods into the diet that enhance the role in DNA methylation. The process behind methylation is to remove the obstacles the body faces that drain the natural methylation process while providing the body with a wide variety of nutrients for optimal balanced activity. This results in a gut that is not as irritated, leading to less gut inflammation and ultimately will reduce inflammation in the overall body, leading to less pain.
An example of breakfast following the methylation diet provided by Lara Zakaria found in the book “Everyday MDL” is Cranberry-Apple- Cinnamon Oatmeal. This meal consists of steel-cut oats, coconut oil, fresh cranberries, a crisp apple, and honey for topping!
Avoiding Nightshades
What is a nightshade?� A nightshade is a vegetable that contains Alkaloids, which are substances containing nitrogen. These nightshades are thought to increase inflammation in the gut and lead to other autoimmune diseases. Many nightshades are a rich source of nutrients and do not cause people issues. However, to reduce overall pain in the body,� avoiding these foods reduces inflammation and offers health benefits.
Examples of common nightshades to avoid include Eggplant, Peppers, Potatoes, and Tomatoes.
Gluten-Free
Joint pain and inflammation are two common symptoms when it comes to celiac disease. Celiac disease is when an individual has an autoimmune response to gluten. Gluten is the protein commonly found in wheat. For those with celiac disease, gluten does not get properly digested, causing damage to the small intestine and the inability to absorb the nutrients.
This leads to painful stomach aches, diarrhea, and inflammation of the intestines and tissues. This causes problems inside the gut, and outside the gut. By reducing gluten in the diet, patients see a reduction of depression, joint pain, headaches, and skin rashes. With the reduction of these symptoms, comes the reduction of pain. The less inflammation being caused from the inside of the body, the less pain felt by the patient.
Phytonutrient Diet
Phytonutrients come from plants. The word “Phyto” refers to the plant, in Greek. Phytonutrients are not essential to live, but they have been shown to help prevent disease and reduce inflammation by providing the body with natural compounds that are produced by plants.
Phytonutrients offer the body antioxidants, carotenoids to support immune health, flavonoids to aid in healthy cell communication that lead to detoxification, and glucosinolates to help eliminate toxins.
On top of all these diets, one of the best things to aid in pain relief is to add all-natural simple supplements into your daily lifestyle. Fish oils will help the body’s cardiovascular system as well as support healthy mental function as well as glucose and insulin metabolism.
Pre/Probiotics will feed the healthy bacteria along with providing a natural immune response, bowel regularity, and lactose digestion.
Vitamin D is a vitamin that almost everyone is deficient in. By adding this supplement to your diet it will support bone health and cardiovascular health.
Curcumin is derived from Tumeric. This is an all-natural supplement that provides antioxidant and cell activity, supports the joints and helps to relieve minor pain, provides the health of organs and their systems while promoting healthy cell growth.
Eating healthy and providing your body with a diet to allow it to work optimally, does not have to be repetitive, plain or boring. These foods and diets allow individuals to enjoy their life and their foods while ultimately reducing inflammation and experiencing pain relief. -Kenna Vaughn, Senior Health Coach
*The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request.�
References:
Hodges, Romilly. �Breakfast.� Everyday MDL Recipes for the Methylation Diet & Lifestyle Program for Optimal Genetic Expression, edited by Kara Fitzgerald , p. 35.
by Dr Alex Jimenez DC, APRN, FNP-BC, CFMP, IFMCP | Functional Medicine, Gut and Intestinal Health, Health
Do you feel:
- Stressed out?
- Agitated, jittery, have tremors?
- Inflammation in the joints and stomach?
- Aches, pain, and swelling throughout the body?
- Hormone imbalances?
If you are experiencing any of these situations, then you might have the holiday blues.
For many people, the holiday season can bring out the chaos, stress, and anxiety in anyone. Even though this time of year is where everyone shows gratitude and peace, it is also the busiest time as well with a never-ending list of things to do that seems to overtake the sense of peace and calm that everyone wants in the holiday season. The occasional anxiety is always around and expected to be part of everyone’s life and is not alarming, like long-term stress. When the body is in a constant fight or flight mode all the time, and a person is running around in a state of chronic stress, it can take a tole of the body and can negatively impact every system, especially in the endocrine system.
HPA Axis Dysfunction
When physiological and emotional stressors are triggered, they release an abundance of cortisol into the body’s circulation that stimulates the HPA (hypothalamic-pituitary-adrenal) axis. When the HPA axis is overactive from a large amount of cortisol, it can wreak havoc on the adrenal glands, thus leading to harmful factors in the endocrine system. Some of the harmful factors include:
- Hormone imbalances
- Inflammation in the gut
- Adrenal exhaustion
- Blood sugar dysregulation
- Decrease in neurocognition
When these harmful factors cause physiologic imbalances in the body, they may lead to being diagnosed as mood disorders like GAD (generalized anxiety disorder) or even more severe conditions like Addison’s disease. With any of these harmful factors, they can elevate glucocorticoid level to critical levels and impacting the production and signaling of two neurotransmitters: GABA (gamma-aminobutyric acid) and serotonin.
Stress Symptoms
There are many characteristics of anxiety and panic disorders that can be manifest in different ways, depending on the person. Some of the common signs and symptoms include:
- Tensed muscles
- Being irritable
- Insomnia
- Shortness of breath
- Panic attacks
- Being tired constantly
Even though there are ways to lower cortisol levels, antidepressant medications like SSRIs (selective serotonin reuptake inhibitors) are usually the first line of treatment in conventional biomedical health. Studies show that even though these medications can help a person, the results are underwhelming due to that antidepressant medication is ineffective when the condition is long term and can cause physiological imbalances to the body. The effects can deplete the nutrients while causing deleterious and unwanted adverse effects that the body does not need.
Anyone who is weaned off from the medication might experience a relapse from the antidepressants and might have a higher risk of discontinuation symptoms in their body. A study showed that about 72% of depressed individuals received a “brief dynamic therapy,” and the results showed that they did not experience any depressive recurrences than the 46% individuals who were treated with antidepressant pharmacotherapy. In a research study, it concluded that the common antidepressant drug was ineffective for patients and provided them with no clinical reduction for their depressive symptoms after six weeks of usage and after twelve weeks of usage, thus providing weak evidence of reducing depressive symptoms.
Beneficial Ways to Reduce Stress
There are many stress-management techniques and strategies to help anyone battle the overwhelming holiday stress and provide optimal health for their bodies. During this hectic season, patients can learn by taking deep breaths, practicing mindfulness, and meditation whenever discomfort starts to rise in their bodies. Research shows that brain mechanisms can affect a person’s behavior and anxiety. By bringing patients’ awareness, they will know that everything will get accomplished, they must recognize that they cannot please everyone, or try to be in two or more places at once. Once they realize that these methods work, they will feel more grounded, and then their bodies will shift their nervous system from sympathetic to parasympathetic.
A recent study showed that regular physical activity could provide beneficial results for anyone that has depression and anxiety while also providing mono- or adjunct-therapy to improve the symptoms. The results showed that a six-week exercise program for college students that are getting ready for finals could adopt a mindful practice once per week to reduce stress and anxiety. In addition to exercise regiment, adding a nutrient-dense, anti-inflammatory, whole food diet that’s rich with polyphenols and macronutrients is fantastic for the body. For anyone, it is best to avoid fatty foods, refined sugars, and carbohydrates to avoid the stimulants and depressants, since it may increase the feelings of stress and anxiety.
For supplements and vitamins, a review that was published earlier this year highlighted the anxiolytic properties of omega-3, PUFAs (polyunsaturated fatty acids), and N-acetyl-cysteine due to their incredible abilities to counter oxidative stress, brain and gut inflammation, and glutamatergic dysfunction while also being a better alternative than consuming pharmaceutical drugs. Taking these supplements is beneficial to the body because it will calm down the body’s stress response, the nervous system, and promote neurotransmitter balance.
Conclusion
Even though it is the holiday system, a person can feel the overbearing stress that comes with the season of giving. There are many ways to reduce holiday stress by finding meditative ways and eating nutritious anti-inflammatory foods to lower down the cortisol levels in the body. When the cortisol levels are high, it can affect the body and the significant systems drastically. Some products are here to help support the body by reducing the effects of temporary stress and offer gastrointestinal and metabolic support.
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.
References:
Faquih, Amber E, et al. �A Review of Novel Antidepressants: A Guide for Clinicians.� Cureus, Cureus, 6 Mar. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6504013/.
Krishnakumar, Divya, et al. �Meditation and Yoga Can Modulate Brain Mechanisms That Affect Behavior and Anxiety-A Modern Scientific Perspective.� Ancient Science, U.S. National Library of Medicine, Apr. 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC4769029/.
Lemay, Virginia, et al. �Impact of a Yoga and Meditation Intervention on Students’ Stress and Anxiety Levels.� American Journal of Pharmaceutical Education, American Journal of Pharmaceutical Education, June 2019, www.ncbi.nlm.nih.gov/pubmed/31333265.
Lewis, Gemma, et al. �The Clinical Effectiveness of Sertraline in Primary Care and the Role of Depression Severity and Duration (PANDA): a Pragmatic, Double-Blind, Placebo-Controlled Randomised Trial.� The Lancet. Psychiatry, U.S. National Library of Medicine, Nov. 2019, www.ncbi.nlm.nih.gov/pubmed/31543474.
Maund, Emma, et al. �Managing Antidepressant Discontinuation: A Systematic Review.� Annals of Family Medicine, American Academy of Family Physicians, Jan. 2019, www.ncbi.nlm.nih.gov/pubmed/30670397.
Rosso, Gianluca, et al. �Five-Year Follow-up of First-Episode Depression Treated with Psychodynamic Psychotherapy or Antidepressants.� Psychiatry Research, U.S. National Library of Medicine, May 2019, www.ncbi.nlm.nih.gov/pubmed/30878853.
Saeed, Sy Atezaz, et al. �Depression and Anxiety Disorders: Benefits of Exercise, Yoga, and Meditation.� American Family Physician, U.S. National Library of Medicine, 15 May 2019, www.ncbi.nlm.nih.gov/pubmed/31083878.
Santos, Patr�cia, et al. �Anxiolytic Properties of Compounds That Counteract Oxidative Stress, Neuroinflammation, and Glutamatergic Dysfunction: a Review.� Revista Brasileira De Psiquiatria (Sao Paulo, Brazil : 1999), Associa��o Brasileira De Psiquiatria, 2019, www.ncbi.nlm.nih.gov/pubmed/30328963.
Team, DFH. �Calm Holiday Stress with Supplements.� Designs for Health, 3 Dec. 2019, blog.designsforhealth.com/node/1162.
Team, NIMH. �Anxiety Disorders.� National Institute of Mental Health, U.S. Department of Health and Human Services, 2018, www.nimh.nih.gov/health/topics/anxiety-disorders/index.shtml#part_145336.
by Dr Alex Jimenez DC, APRN, FNP-BC, CFMP, IFMCP | Functional Medicine, Health, Nutrition, Remedies, Wellness
Do you feel:
- Agitated, easily upset, or have tremors?
- Afternoon fatigues?
- Mental sluggishness?
- Tired?
- Stressed out?
If you are feeling any of these situations, then you might be experiencing low levels of glutathione, why not add some S-acetyl glutathione into your body.
Glutathione
When glutathione is decreased in the body, it is known as glutathione deficiency or GSH. It is a tripeptide that is consist of L-glutamine, L-cysteine, and glycine while also being functional in the systems of the body. The biosynthesis of glutathione can be affected by some factors such as biochemical individuality or dietary factors. Another factor that can affect glutathione in the body is chronic oxidative stress. Chronic oxidative stress can deplete cellular glutathione in the body, causing it to develop inflammation and dysfunction to its organ systems.
There are ways to boost glutathione levels in the body since these nutrients and supplements are the precursors to glutathione. They consist of whey protein, vitamin C, and glutamine, and they can help raise the glutathione levels in the body to prevent inflammation and disruptive factors that can cause harm to the body; however, the results are inconsistent and need further research. Studies stated that biological individuality is different to every type of body since it is equivalent and can metabolize the precursor nutrients and supplements to the body.
Why Not Distribute Pure Glutathione?
Sadly though, when a person takes glutathione in an oral form, the results are unpleasant. When the person takes glutathione in the mouth, the oral dosage is oxidized instantly, before being absorbed into the body, thus leaving a foul smell. Taking glutathione in a vegetable capsule can help the individual receive glutathione without it being oxidized.
Many formulas can deliver a unique preparation to glutathione that can overcome the limitations it faces. Studies show that S-acetyl glutathione is stable enough to go through the intestinal walls and deposit the necessary nutrients into the body. With S-acetyl glutathione being consumed orally, it can increase the total glutathione and the percent-reduced glutathione so it can be beneficial for the body. With percent-reduced glutathione, it has a very significant biomarker for excellent status for a functional body.
The Mechanics of SAG Absorption
S-acetyl glutathione or SAG is a lipid-like compound that is taken by intact chylomicrons in the gut. The bond from this compound is placed into its thiol group that helps prevents oxidations in the body and allows molecules to pass into the cell walls after being absorbed into the gut. What happens is that the bond is cleaved by non-specific enzymes and helps prevent the breakdown of glutathione, while S-acetyl glutathione does not need expenditures to be cleaved once it crosses the cell walls in the body.
SAG Antioxidant Activity
Since glutathione helps tissue and organ functions throughout the body, it plays a critical role by protecting it from a variety of factors like, for example, oxidative stress, while also maintain cellular functions and supporting a healthy immune system. Studies show that many factors can increase oxidative stress exposure and adding insults to the body, therefore increasing the cellular consumption of the nutrients like glutathione, which provides antioxidant activity. When this happens, it leads to the result of a fiery cycle of oxidative stress and challenges detoxification to the body. Research states that complete biotransformation and protecting the body from oxidative stress is essential for the body to maintain cellular integrity and tissue health.
Benefits of Maintaining Healthy Glutathione Levels
There is plenty of information that is related to cellular health that has been surfaced. Research states that the mitochondria, which is the energy-producing powerhouse cell, has a role in being the primary functional cellular site for consuming oxygen and ROS (reactive oxygen species).� Studies show that S-acetyl glutathione can cross the membranes of the mitochondria by increasing the organ’s activity and minimizing ROS in the body. When ROS is reduced in the body, it can maintain the mitochondrial integrity and its function, while improving its health for the body to function correctly.
Studies show that S-acetyl glutathione can decrease TNF-alpha, NF-kappa beta, and F-2 isoprostane enzymes in the body. Additional studies show that there is a large amount of evidence that intracellular glutathione levels in macrophages can influence the Th1/Th2 cytokine pattern and can help promote a well-balanced immune reaction to the body.
Conclusion
Glutathione is an essential amino acid that is produced in the body. When there are low levels of glutathione in the body, S-acetyl glutathione can assist in maintaining those levels and by making sure that oxidative stress does not reach full capacity in the body to cause significant damage. Some products can provide more excellent stability, bioavailability, and digestive comfort for anyone who might be sensitive to N-acetyl L-cysteine.
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.
References:
Anderson, Michelle F, et al. �Glutathione Monoethylester Prevents Mitochondrial Glutathione Depletion during Focal Cerebral Ischemia.� Neurochemistry International, Pergamon, 20 June 2003, www.sciencedirect.com/science/article/abs/pii/S0197018603001335?via%3Dihub.
Ballatori, Nazzareno, et al. �Glutathione Dysregulation and the Etiology and Progression of Human Diseases.� Biological Chemistry, U.S. National Library of Medicine, Mar. 2009, www.ncbi.nlm.nih.gov/pmc/articles/PMC2756154/.
Fraternale, A., et al. �Antiviral and Immunomodulatory Properties of New Pro-Glutathione (GSH) Molecules.� Http://Www.eurekaselect.com, 31 May, 2006, www.eurekaselect.com/56205/article.
Kretzschmar, M. �Regulation of Hepatic Glutathione Metabolism and Its Role in Hepatotoxicity.� Experimental and Toxicologic Pathology, Urban & Fischer, 3 Nov. 2011, www.sciencedirect.com/science/article/abs/pii/S0940299396800546?via%3Dihub.
Locigno, Roberto, et al. �S-Acetyl-Glutathione Selectively Induces Apoptosis in Human Lymphoma Cells through a GSH-Independent Mechanism.� International Journal of Oncology, U.S. National Library of Medicine, Jan. 2002, www.ncbi.nlm.nih.gov/pubmed/11743644.
Lomaestro, Ben M, and Margaret Malone. �Glutathione in Health and Disease: Pharmacotherapeutic Issues – Ben M Lomaestro, Margaret Malone, 1995.� SAGE Journals, 1 Dec. 1995, journals.sagepub.com/doi/10.1177/106002809502901213.
Richman, PG, and A Meister. “Regulation of Gamma-Glutamyl-Cysteine Synthetase by Nonallosteric Feedback Inhibition by Glutathione.� The Journal of Biological Chemistry, U.S. National Library of Medicine, 25 Feb. 1975, www.ncbi.nlm.nih.gov/pubmed/1112810.
Vogel, Jens-Uwe, et al. �Effects of S-Acetylglutathione in Cell and Animal Model of Herpes Simplex Virus Type 1 Infection.� SpringerLink, Springer-Verlag, 18 Nov. 2003, link.springer.com/article/10.1007%2Fs00430-003-0212-z.
Whelan, Corey. �Glutathione Benefits.� Healthline, 21 Nov. 2017, www.healthline.com/health/glutathione-benefits.
by Dr Alex Jimenez DC, APRN, FNP-BC, CFMP, IFMCP | Functional Medicine, Health, Nutrition, Supplements, Wellness
Do you feel:
- Afternoon fatigue?
- Under a high amount of stress?
- Mental sluggishness?
- Headaches with exertion or stress?
- Inflammation in certain parts in your body?
If you are experiencing any of these situations, then you might have suffered from glutathione deficiency, why not trying some NAC supplements.
NAC and Its Benefits
NAC or N-Acetyl Cysteine is an amazing semi-essential amino acid. This amino acid can be produced from the body through other amino acids like methionine and serine. It can only become an essential amino acid when dietary intake of methionine and serine are low in the body. When a person is trying to incorporate NAC in their diet, it can be found in high protein foods like meats, dairies, and legumes. Studies show that consuming NAC is essential for a variety of health reasons, especially replenishing the most potent antioxidant, glutathione in the body.
Since NAC is a nutritional supplement that is exceedingly powerful, it can help glutathione be elevated in biosynthesis. NAC is recognized for supporting average mucous production, respiratory function, and eye health positively. Research shows that NAC can protect cell and tissue health from chronic illnesses and providing support for a healthy mental status in the body. There is even more research on NAC supplements, especially when someone increases their intake on the supplement. When there is an increase in NAC, and when it is consumed in the body, the effects are astounding. The NAC supplements can help the body boost the levels of some of the neurotransmitters and improving mental health.
In a 2011 study, researchers found that NAC is emerging to be a useful agent to help treat psychiatric disorders. The results of using NAC supplements to treat psychiatric disorders has helped alleviate some of these symptoms:
- Addiction
- Compulsive and grooming disorders
- Schizophrenia
- Bipolar disorders
- Alzheimer�s disease
Since NAC can exert beneficial effects on the body, this supplement is useful to provide antioxidant, neuropathy, and anti-inflammatory properties to make sure that the body is functioning. Studies show that NAC can improve the outcomes of reducing lipopolysaccharides inflammation and preventing oxidative stress from being overexposed.
With NAC being a sulfur-containing derivative for the amino acid L-cysteine, this supplement provides supportive antioxidants and detoxification mechanisms for the body. Studies show that NAC can support the body�s antioxidant activity by neutralizing highly reactive hydroxyl radicals and serving as a source to sulfhydryl groups. They are thus enhancing the production or tripeptide glutathione in the body since it is a crucial component for antioxidant and detoxification enzymes.
Glutathione
Glutathione is a powerful antioxidant that has recently gained attention for its fantastic health benefits. This powerful antioxidant is found in every cell in the human body and can be absorbed in oral form. Research shows that even though the absorption of oral glutathione may be limited, the NAC supplementation can significantly increase the circulating levels of glutathione in the body. Studies stated that individuals who are infected with HIV, have glutathione deficiency in their system and have been associated with an impaired T-cell function and survival. So taking NAC orally can be used to replenish glutathione deficiency and is useful in the HIV infection.
Another study showed that taking NAC orally can help improve the responses of patients with chronic lung disease (CLD), chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF). The beneficial effects of taking NAC orally shows a decrease of inflammation in the lungs, improving the lung function, and reducing the neutrophil burden in cystic fibrosis airways.
Once this is done, though, NAC can help promote the production of glutathione and incorporate it into the crucial antioxidant enzymes and detoxification enzymes. With these enzyme activities being in play in the body, the glutathione is helping out by directly supporting their activities and the metabolism breakdown. Glutathione can also participate in fatty acid synthesis and can transport across the cell membrane.
Glutathione Factors
There are a variety of factors that can determine the requirements that glutathione can provide for the body. Glutathione can help control the toxin level exposure, increase the detoxification, and provide the overall needed support for antioxidants. Studies show that maintaining glutathione levels are essential to maintain the necessary health of the respiratory, hepatic, and the immune system from inflammation.
Research shows that since glutathione has multiple metabolic actions, they are essential for cellular homeostasis. Since it plays an important role, diseases like HIV, oxidative stress, chronic lung disease, and COPD can lower the body’s glutathione. The best way to make sure that individuals who have any chronic diseases, take NAC orally to prevent glutathione deficiency.
Glutathione can even help support antioxidant protection for lipids and proteins for the body as well as helping to maintain the standard response of inflammation due to injury. Studies show that elderly adults have altered their cellular redox levels and their dysregulated immune responses. Researchers also found out that the progression of chronic degenerative diseases of aging and that glutathione decreases with age naturally.
Conclusion
NAC is a semi-essential amino acid that has outstanding properties for the body. It helps replenishes the body�s glutathione and alleviate the symptoms caused by chronic illnesses. Taking NAC supplements is highly essential since it helps maintain adequate levels of glutathione to support overall health and well-being in the body. Some products help support glutathione levels as well as working well with NAC supplements by providing more excellent stability, bioavailability, and digestive comfort.
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.
References:
Atkuri, Kondala R, et al. �N-Acetylcysteine–a Safe Antidote for Cysteine/Glutathione Deficiency.� Current Opinion in Pharmacology, U.S. National Library of Medicine, Aug. 2007, www.ncbi.nlm.nih.gov/pmc/articles/PMC4540061/.
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Favier, A., et al. �Antioxidant Status and Lipid Peroxidation in Patients Infected with HIV.� Chemico-Biological Interactions, Elsevier, 23 Jan. 2003, www.sciencedirect.com/science/article/abs/pii/000927979490037X?via%3Dihub.
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Nakamura, Hajime, et al. �Redox Imbalance and Its Control in HIV Infection.� Mary Ann Liebert, Inc., Publishers, 5 July 2004, www.liebertpub.com/doi/10.1089/15230860260196245.
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Pace, Gary W., and Cynthia D. Leaf. �The Role of Oxidative Stress in HIV Disease.� Free Radical Biology and Medicine, Pergamon, 14 Jan. 2000, www.sciencedirect.com/science/article/abs/pii/0891584995000472?via%3Dihub.
Roberts, Robert L., et al. �N -Acetylcysteine Enhances Antibody-Dependent Cellular Cytotoxicity in Neutrophils and Mononuclear Cells from Healthy Adults and Human Immunodeficiency Virus-Infected Patients.� OUP Academic, Oxford University Press, 1 Dec. 1995, academic.oup.com/jid/article-abstract/172/6/1492/820544?redirectedFrom=fulltext.
Rosa, De, et al. �N?Acetylcysteine Replenishes Glutathione in HIV Infection.� Wiley Online Library, John Wiley & Sons, Ltd (10.1111), 24 Dec. 2001, onlinelibrary.wiley.com/doi/abs/10.1046/j.1365-2362.2000.00736.x.
White, Alexander C., et al. �Glutathione Deficiency in Human Disease.� The Journal of Nutritional Biochemistry, Elsevier, 17 Jan. 2003, www.sciencedirect.com/science/article/abs/pii/0955286394900396.
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