Shaky, jittery, or have tremors throughout your body?
If you are experiencing any of these situations, then it might be your blood-brain barrier and your endocrine system that may be imbalanced.
The brain in the human body is the primary control system that makes sure that each of the body’s system is working correctly. This includes the gastrointestinal system, the hepatic system, the neurological system, and, most importantly, the endocrine system. In the brain, however, there is a tissue known as the blood-brain barrier, it is connected to the endocrine system. It is essential to make sure that the blood-brain barrier and the endocrine system are healthy in the human body.
The Blood-Brain Barrier
The blood-brain barrier in the body separates the central nervous system from peripheral tissue. Even though the blood-brain barrier separates the nervous system, it does not prevent hormones from entering the brain. Research shows that the brain can bind and secretes any circulating substances and can be qualified as an endocrine organ. When this happens, it can be one of the largest and most metabolically active of the endocrine organs by acting as both the target and secretor of hormones.
With the blood-brain barrier, it conveys the blood vessels by transporting the blood from the heart to every tissue and organs throughout the body. It then delivers oxygen and the nutrients to all the tissues and removing the carbon dioxide and metabolic waste from the tissues. The blood vessels also convey hormonal signals to the tissues and is a mediator for interacting with the peripheral immune system with each tissue. Research shows that since the blood-brain barrier is an endocrine tissue, the substances that are being carried in the blood can emerge in a hormone-like fashion. The research stated that the blood-brain barrier could exhibit the endocrine system properties as well as being a target for hormones that can affect many of the blood-brain functions in the body.
The Endocrine System
The endocrine system is a collection of glands that secretes out and produces hormones that can regulate not only the body but makes sure that it regulates the body’s metabolism and many other functions that the body needs to function correctly. When the body’s hormone levels fluctuate, it can be very good or horrible, depending on the situation. If the body produces an abundance of hormones, it can cause a person to have hyperthyroidism, and when the body produces a low abundance of hormones, the body can have complications and cause the body to develop chronic illnesses. Stress, infections, and diabetes can influence the body’s hormone levels by making hormones either too much or too little. By making sure that the body’s hormones are at a balanced level is essential because eating right and doing daily exercises can make the body function properly and feel good as well.
Since the body can produce hormones naturally, the job of the primary hormone is to make sure that it is traveling in the bloodstream and making it to the various organs and tissues that need the hormone levels. The hormone levels can tell every organ and tissues what to do and how to function. When the hormone levels get crazy by being produced too much or too little, it causes those organs and tissues to malfunction.
For the blood-brain barrier, since it is an endocrine tissue, it can divide the hormone receptors. The research found out that the blood-brain barrier can respond to circulate the hormone substances and secrete those hormone substances into the blood circulation and the central nervous system. It can also make sure that when the hormone receptors are being divided that it goes to the central nervous tissues and the peripheral tissues. The research also found out that insulin levels can also affect the brain’s endothelial cell function through several parameters and modulating amino acids, leptin, and p-glycoprotein transporters in the body.
Surprisingly there is a unique feature that the blood-brain barrier possesses. The blood-brain relies on its cell membrane surfaces facing into the bloodstream and the interstitial fluid of the central nervous system so that way it can receive signals for the body. The research found out that the blood-brain barrier’s properties are primarily manifested within the brain’s endothelial cells. They can be induced and maintained through critical interactions with the cells that are interacting in the neurovascular unit in the brain. With these endocrine-like mechanisms that the blood-brain barrier has, it can help dampen the effects of endocrine diseases like neurodegenerative conditions and Alzheimer’s disease.
Conclusion
The blood-brain barrier is an essential tissue in the brain as it functions as an endocrine tissue and does play a role by interacting with the hormone levels that the endocrine system secreted out to the body. When the hormone levels start to malfunction by either producing an abundance or too little amount of hormones, it can cause the body to have chronic illnesses and the blood-brain barrier to dysfunction in the brain, causing degenerative neurological disorders in the brain as well. Some products can help the endocrine system by making sure the hormone levels are balanced as well as products for a healthy brain function for a healthy body.
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.
References:
Banks, William A. �Brain Meets Body: the Blood-Brain Barrier as an Endocrine Interface.� Endocrinology, Endocrine Society, Sept. 2012, www.ncbi.nlm.nih.gov/pmc/articles/PMC3423627/.
Banks, William A. �The Blood-Brain Barrier as an Endocrine Tissue.� Nature Reviews. Endocrinology, U.S. National Library of Medicine, Aug. 2019, www.ncbi.nlm.nih.gov/pubmed/31127254.
Daneman, Richard, and Alexandre Prat. �The Blood-Brain Barrier.� Cold Spring Harbor Perspectives in Biology, Cold Spring Harbor Laboratory Press, 5 Jan. 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC4292164/.
Zimmermann, Kim Ann. �Endocrine System: Facts, Functions and Diseases.� LiveScience, Purch, 18 Feb. 2018, www.livescience.com/26496-endocrine-system.html.
The University offers a wide variety of medical professions for functional and integrative medicine. Their goal is to inform individuals who want to make a difference in the functional medical fields with knowledgeable information that they can provide.
Blood vessels in the brain protect us from “harmful” components in the bloodstream. This is known as the blood-brain barrier. A Science Translational Medicine research study demonstrated how inflammation and cognitive impairment in a group of aging mice may be associated with the breakdown of the blood-brain barrier. In the following article, we will discuss how restoring the breakdown of the blood-brain barrier may improve overall brain health. �
What is a Leaky Blood-Brain Barrier?
Scientists determined that the breakdown of the blood-brain barrier can ultimately trigger a signaling protein in brain cells, known as astrocytes. They then created and evaluated a drug/medication that blocked the activation of the astrocytes, or the signaling protein known as the transforming growth factor-beta (TGF-beta). Following the treatment, the group of aging mice demonstrated reduced brain inflammation and improved cognitive function. �
“Our team of scientists associates the aging brain in the same way we associate neurodegeneration. The aging brain is characterized by loss of cognitive function and dead brain cells,” stated Daniela Kaufer, co-senior author and professor of integrative biology at the University of California, Berkeley. “However, our research study determined a different story about why the aging brain doesn’t function properly: It is because of brain fog,” she concluded. �
According to the research study, reducing inflammation and brain fog by restoring the breakdown of the blood-brain barrier can help improve the overall health and wellness of the aging brain. The results may also help scientists understand how cognitive impairment associated with inflammation and brain fog can accompany the aging brain and neurodegeneration as well as how the blood-brain barrier may be associated with improved brain function. �
Inflammation, Brain Fog, and Cognitive Impairment
A variety of research studies, including imaging research studies performed by Alon Friedman, co-senior author of Ben-Gurion University of the Negev in Israel and Dalhousie University in Canada, discussed the breakdown of the blood-brain barrier and how it can ultimately become less effective with age. A “leaky” blood-brain barrier can make it easier for “harmful” compounds to penetrate the brain and damage cells and tissue from the bloodstream. �
Kaufer and Friedman are also co-senior authors of another Science Translational Medicine research study that evaluated inflammation and brain fog in leaky blood-brain barriers. By way of instance, patients with Alzheimer’s disease may experience epileptic episodes, however, they may not be aware of them. Aging is a risk factor for Alzheimer’s disease and epilepsy where research studies have associated a connection between the two brain health issues. �
For the second research study, the team of scientists evaluated EEG readings from patients with Alzheimer’s disease and determined an EEG signature for what is ultimately known as paroxysmal slow wave events (PSWEs). From the EEGs, the scientists demonstrated how the rate of PSWEs appeared to match the level of cognitive impairment of the patients. In EEGs of patients with epilepsy, they demonstrated that PSWEs that happened between seizures matched cases of leaky blood-brain barriers. They determined the same match in aging mice, mice prone to Alzheimer’s disease, and rats with induced epilepsy. �
Further research studies in young rats also demonstrated that the blood-brain barrier can start to breakdown by introducing the protein albumin to the brain. According to the results, this ultimately caused an increased rate of PSWEs. Friedman and Kaufer also demonstrated that the protein albumin can penetrate the blood-brain barrier following trauma. The protein albumin can attach itself to the TGF-beta receptor of astrocytes and cause brain health issues. The team of scientists also concluded that a leaky blood-brain barrier may ultimately be a cause of inflammation, brain fog, and cognitive impairment. �
Leaky Blood-Brain Barrier Biomarkers
The scientists suggest that the results of the various research studies on leaky blood-brain barriers and brain health ultimately help offer a variety of biomarkers that could possibly help healthcare professionals recognize these type of problems by using MRI, which can detect leaky blood-brain barriers, and using EEG, which can detect abnormal brain rhythms. The outcome measures may also help develop the treatment that they may use as a way to restore a leaky blood-brain barrier to reduce and even reverse several of the brain health issues it may ultimately cause, including neurodegeneration. �
“Our team of scientists now use several biomarkers that demonstrate leaky blood-brain barriers, so healthcare professionals can choose patients for treatment,” stated professor Daniela Kaufer. “These research studies ultimately support the effects of leaky blood-brain barriers on a variety of brain health issues, including dementia and Alzheimer’s disease, associated with inflammation, brain fog, and cognitive impairment as well as offer possible results for future research studies,” stated Diego Gomez-Nicola, an associate professor of neuroscience at the University of Southampton in the United Kingdom, �
After the discoveries of the German scientist Paul Ehrlich during the late 1800s, a collection of experiments on a group of mice demonstrated how the brain regulates what to permit passage to and what to block from entering its blood vessels through the blood-brain barrier. The brain is ultimately protected by the blood-brain barrier, however, this security system can frequently prevent drugs and/or medications from being able to effectively treat brain health issues. Scientists have started working towards developing successful ways to allow treatments to penetrate the blood-brain barrier. Other research studies have demonstrated that by the aging brain, as well as neurodegeneration, can cause the breakdown of the blood-brain barrier. A leaky blood-brain barrier can ultimately cause inflammation, brain fog, and cognitive impairment. However, research studies have demonstrated ways to restore and even reverse leaky blood-brain barriers and several brain health issues. – Dr. Alex Jimenez D.C., C.C.S.T. Insight
Neurotransmitter Assessment Form
The following Neurotransmitter Assessment Form can be filled out and presented to Dr. Alex Jimenez. The following symptoms listed on this form are not intended to be utilized as a diagnosis of any type of disease, condition, or any other type of health issue. �
Blood vessels in the brain protect us from “harmful” components in the bloodstream. This is known as the blood-brain barrier. A Science Translational Medicine research study demonstrated how inflammation and cognitive impairment in a group of aging mice may be associated with the breakdown of the blood-brain barrier. In the following article, we will discuss how restoring the breakdown of the blood-brain barrier may improve overall brain health. �
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.�
Curated by Dr. Alex Jimenez �
References:
Catharine Paddock, Ph.D. �Repairing Leaky Blood-Brain Barrier May Rejuvenate Brain Function.� Medical News Today, MediLexicon International, 6 Dec. 2019, www.medicalnewstoday.com/articles/327248.php#1.
Additional Topic Discussion: Chronic Pain
Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals, however, chronic pain is different than the average type of pain. With chronic pain, the human body will continue sending pain signals to the brain, regardless if the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient’s mobility and it can reduce flexibility, strength, and endurance. �
Neural Zoomer Plus for Neurological Disease
�
Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual�s reactivity to 48 neurological antigens with connections to a variety of neurologically related diseases. The Vibrant Neural ZoomerTM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention. �
Food Sensitivity for the IgG & IgA Immune Response
�
Dr. Alex Jimenez utilizes a series of tests to help evaluate health issues associated with food sensitivities. The Food Sensitivity ZoomerTM is an array of 180 commonly consumed food antigens that offers very specific antibody-to-antigen recognition. This panel measures an individual�s IgG and IgA sensitivity to food antigens. Being able to test IgA antibodies provides additional information to foods that may be causing mucosal damage. Additionally, this test is ideal for patients who might be suffering from delayed reactions to certain foods. Utilizing an antibody-based food sensitivity test can help prioritize the necessary foods to eliminate and create a customized diet plan around the patient�s specific needs. �
Gut Zoomer for Small Intestinal Bacterial Overgrowth (SIBO)
�
Dr. Alex Jimenez utilizes a series of tests to help evaluate gut health associated with small intestinal bacterial overgrowth (SIBO). The Vibrant Gut ZoomerTM offers a report that includes dietary recommendations and other natural supplementation like prebiotics, probiotics, and polyphenols. The gut microbiome is mainly found in the large intestine and it has more than 1000 species of bacteria that play a fundamental role in the human body, from shaping the immune system and affecting the metabolism of nutrients to strengthening the intestinal mucosal barrier (gut-barrier). It is essential to understand how the number of bacteria that symbiotically live in the human gastrointestinal (GI) tract influences gut health because imbalances in the gut microbiome may ultimately lead to gastrointestinal (GI) tract symptoms, skin conditions, autoimmune disorders, immune system imbalances, and multiple inflammatory disorders. �
Formulas for Methylation Support
XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly,�Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic�Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
�
�
For your convenience and review of the XYMOGEN products please review the following link. *XYMOGEN-Catalog-Download �
* All of the above XYMOGEN policies remain strictly in force. �
Our brain is a complex organ protected by our 7mm thick skull, a protective membrane, known as the meninges, and cerebrospinal fluid. These essential brain structures help protect the brain against physical damage or injury. Another brain structure that protects the brain from harm is the blood-brain barrier. The blood-brain barrier is the shield between the brain’s blood vessels and the cells in the brain’s tissue. While the skull, meninges, and cerebrospinal fluid protect the brain from physical damage or injury, the blood-brain barrier protects the brain from toxins and pathogens in the bloodstream. �
Moreover, the presence of the blood-brain barrier in the human brain was first discovered in the late 1800s by the German scientist Paul Ehrlich when he injected blue dye in the bloodstream of a group of mice during an experiment. The blue dye strained all of the animals’ tissues and organs with the exception of the brain and spinal cord. Although the outcome measures of the research study demonstrated the existence of the blood-brain barrier, it wasn’t until the 1960s that researchers were able to use much more powerful technologies to ultimately prove the presence of the blood-brain barrier in the human brain. �
Anatomy of the Blood-Brain Barrier
The main structure of the blood-brain barrier that helps protect the brain from toxins and pathogens in the bloodstream is known as the endothelial tight junction. The endothelial cells cover the inside of the blood vessels in the brain. The blood-brain barrier is such an effective security system because these endothelial cells in the blood vessels in the brain are connected extremely close to each other in “tight junctions”. The blood-brain barrier only permits small, fat-soluble molecules and several types of gases to pass freely between the blood vessels and the brain. Furthermore, bigger molecules, such as glucose and insulin, are only permitted passage through transporter proteins which act like “bouncers” that only open the doors for certain necessary molecules. �
The purpose of the blood-brain barrier is to protect the brain against toxins and pathogens circulating in the bloodstream that could cause brain health issues while also permitting passage to fundamental nutrients that are necessary for the brain. Other functions of the blood-brain barrier include regulating and managing consistent levels of nutrients, hormones, and water in the human brain. Changes in these may affect the homeostasis of the brain. �
The homeostasis of the brain can commonly be affected by bacterial infections, such as meningococcal disease. Meningococcal bacteria can attach to the endothelial cells of the blood vessels in the brain and cause the tight junctions to slightly open. This causes the blood-brain barrier to become more porous which can then permit passage to toxins and pathogens that can infect the brain tissue, leading to inflammation and sometimes even death. It�s also believed that the blood-brain barrier can decrease in a variety of other brain health issues. In multiple sclerosis, by way of instance, decreased blood-brain barrier function may permit white blood cells to pass into the brain and attack the structures that transmit messages from one neuron to another. �
Blood-Brain Barrier Treatment
The blood-brain barrier is so effective at protecting the brain from toxins and pathogens that it can even block necessary treatments from reaching the brain. The vast majority of potential drugs and/or medications that could help treat a variety of brain health issues aren’t able to readily penetrate the blood-brain barrier which may become a tremendous problem in treating neurological diseases. However, one possible way to penetrate the blood-brain barrier is to �trick� the security system into permitting passage to certain medicines. The blood-brain barrier can also be temporarily opened using ultrasound. �
One research study demonstrated that using ultrasound to temporarily open the blood-brain barrier in a mouse with Alzheimer�s disease can improve cognition and decrease toxic plaques in the brain. But most importantly, using ultrasound to temporarily open the blood-brain barrier didn�t damage or injure the brain. In another research study, researchers demonstrated that by temporarily opening the blood-brain barrier, ultrasound can permit the passage of drugs and/or medications into the brain, improving cognition and Alzheimer’s disease more than when using ultrasound or medicines alone. �
After the discoveries of the German scientist Paul Ehrlich during the late 1800s, a collection of experiments on a group of mice demonstrated how the brain regulates what to permit passage to and what to block from entering its blood vessels through the blood-brain barrier. The brain is ultimately protected by the blood-brain barrier, however, this security system can frequently prevent drugs and/or medications from being able to effectively treat brain health issues. Scientists have started working towards developing successful ways to allow treatments to penetrate the blood-brain barrier. Other research studies have demonstrated that by using ultrasound, the blood-brain barrier can be temporarily opened to permit passage for medicines to help treat a variety of brain health issues and neurological diseases, among other problems.�- Dr. Alex Jimenez D.C., C.C.S.T. Insight
Neurotransmitter Assessment Form
The following Neurotransmitter Assessment Form can be filled out and presented to Dr. Alex Jimenez. The following symptoms listed on this form are not intended to be utilized as a diagnosis of any type of disease, condition, or any other type of health issue. �
Our brain is a complex organ that is protected by our 7mm thick skull, a protective membrane, known as the meninges, and cerebrospinal fluid. These essential brain structures ultimately help protect the brain against physical damage or injury. Another brain structure that protects the brain from harm is the blood-brain barrier. The blood-brain barrier is the shield between the brain’s blood vessels and the cells in the brain’s tissue. While the skull, meninges, and cerebrospinal fluid protect the brain from physical damage or injury, the blood-brain barrier protects the brain from toxins and pathogens in the bloodstream. �
Moreover, the presence of the blood-brain barrier in the human brain was first discovered in the late 1800s by the German scientist Paul Ehrlich when he injected blue dye in the bloodstream of a group of mice during an experiment. The blue dye strained all of the animals’ tissues and organs with the exception of the brain and spinal cord. Although the outcome measures of the research study demonstrated the existence of the blood-brain barrier, it wasn’t until the 1960s that researchers were able to use much more powerful technologies to ultimately prove the presence of the blood-brain barrier in the human brain. �
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.�
Curated by Dr. Alex Jimenez �
References:
Woodruff, Alan. �What Is the Blood-Brain Barrier?� Queensland Brain Institute, 11 Jan. 2018, qbi.uq.edu.au/brain/brain-anatomy/what-blood-brain-barrier.
Additional Topic Discussion: Chronic Pain
Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals, however, chronic pain is different than the average type of pain. With chronic pain, the human body will continue sending pain signals to the brain, regardless if the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient’s mobility and it can reduce flexibility, strength, and endurance. �
Neural Zoomer Plus for Neurological Disease
Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual�s reactivity to 48 neurological antigens with connections to a variety of neurologically related diseases. The Vibrant Neural ZoomerTM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention. �
Food Sensitivity for the IgG & IgA Immune Response
Dr. Alex Jimenez utilizes a series of tests to help evaluate health issues associated with food sensitivities. The Food Sensitivity ZoomerTM is an array of 180 commonly consumed food antigens that offers very specific antibody-to-antigen recognition. This panel measures an individual�s IgG and IgA sensitivity to food antigens. Being able to test IgA antibodies provides additional information to foods that may be causing mucosal damage. Additionally, this test is ideal for patients who might be suffering from delayed reactions to certain foods. Utilizing an antibody-based food sensitivity test can help prioritize the necessary foods to eliminate and create a customized diet plan around the patient�s specific needs. �
Gut Zoomer for Small Intestinal Bacterial Overgrowth (SIBO)
Dr. Alex Jimenez utilizes a series of tests to help evaluate gut health associated with small intestinal bacterial overgrowth (SIBO). The Vibrant Gut ZoomerTM offers a report that includes dietary recommendations and other natural supplementation like prebiotics, probiotics, and polyphenols. The gut microbiome is mainly found in the large intestine and it has more than 1000 species of bacteria that play a fundamental role in the human body, from shaping the immune system and affecting the metabolism of nutrients to strengthening the intestinal mucosal barrier (gut-barrier). It is essential to understand how the number of bacteria that symbiotically live in the human gastrointestinal (GI) tract influences gut health because imbalances in the gut microbiome may ultimately lead to gastrointestinal (GI) tract symptoms, skin conditions, autoimmune disorders, immune system imbalances, and multiple inflammatory disorders. �
Formulas for Methylation Support
� XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly,�Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic�Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
�
For your convenience and review of the XYMOGEN products please review the following link. *XYMOGEN-Catalog-Download �
* All of the above XYMOGEN policies remain strictly in force. �
Our brain is protected by the blood-brain barrier, a connection of blood vessels that permits the passage of important nutrients while blocking other compounds. However, this security system is so efficient at guarding the brain that it can frequently prevent many drugs and/or medications from being able to effectively treat a variety of brain health issues. Scientists are working towards developing ways to allow treatments to penetrate the blood-brain barrier. �
The brain depends on a variety of precise communication signals from the nerve cells to perform many fundamental functions. And it’s surrounding environment must remain stable to successfully send and receive transmissions. During the late 1800s, the outcome measures of a research study on the brain started a collection of experiments that demonstrated how the brain ultimately protects itself from the natural changes that happen in the body. �
Understanding the Blood-Brain Barrier
Paul Ehrlich, a German scientist that later earned a Nobel Prize for developing a cure for syphilis, was first interested in the way that several different types of cells and tissues absorb various chemical dyes. The purpose of Ehrlich’s experiments was to discover new components that could protect the brain from other “harmful” compounds. However, Paul Ehrlich made an unexpectedly strange discovery throughout the course of his research studies. �
During a research study in 1885, Ehrlich injected blue dye into the bloodstream of a group of mice. The dye stained all of the animals’ organs blue with the exception of one essential organ: their brains. During a follow-up research study in 1913, the same blue dye previously used for the last experiment was directly injected into the brains of another group of mice. But this time, the animals’ brains turned blue while the other organs did not change color. �
While these experiments discovered the blood-brain barrier, there was no such equipment at the time that could have demonstrated the existence of this security system. As a matter of fact, it wasn’t until the 1960s that scientists detected the actual blood-brain barrier for the first time.� Scientists were able to see the detailed connection of blood vessels in the brain using a microscope that was about 5,000 times more powerful than the one Paul Ehrlich used. �
Scientists also discovered that, much like all of the other blood vessels in the body, the blood vessels in the brain are filled with endothelial cells which function as a sort of connection between the blood and vessel wall. Unlike all of the other blood vessels in the body, however, the endothelial cells in the brain are closely attached together which forms an almost impermeable barrier between the brain and the bloodstream: the blood-brain barrier. �
The blood-brain barrier permits the passage of nutrients and hormones, such as glucose and amino acids, while blocking “harmful” components, such as bacteria and toxins, from entering the brain. In order to demonstrate how the brain’s security system determines which molecules to permit passage to and which molecules to block, scientists injected certain compounds into the bloodstream of animals and then measured the amounts that arrived in the brain. �
Blood-Brain Barrier and Brain Health Issues
Over the course of several research studies, scientists demonstrated that certain compounds that are very small and/or fat-soluble, including anti-anxiety medicines, antidepressants, cocaine, alcohol, and many different types of hormones can slip through the endothelial cells of the blood-brain barrier. Bigger, more desirable molecules, including glucose and/or insulin, must be selectively carried across the blood-brain barrier by transporter proteins. �
Nerve cells found on either side of the blood-brain barrier are constantly communicating with one another regarding which molecules they should permit passage to and which components to block. By way of instance, nerve cells working hard within the brain may ultimately transmit signals to the blood vessels on either side of the blood-brain barrier for them dilate and allow nutrients to rapidly travel from the bloodstream to the nerve cells in need. �
However, several brain health issues, including injuries, underlying conditions, infections, and certain types of cancers, can cause the blood-brain barrier to become damaged and break down, resulting in tiny ruptures to the blood vessels in the brain. A variety of components that would normally be blocked by the blood-brain barrier can then be permitted passage, causing various problems for the brain, including a variety of neurological diseases. �
Moreover, outcome measures from several research studies suggest that the weakening of the blood-brain barrier may even be associated with a number of neurodegenerative disorders. For example, scientists suggest that a leaky blood-brain barrier permits the passage of too many white blood cells into the brains of patients with multiple sclerosis (MS). These cells attack the myelin sheath between the nerve cells, causing multiple sclerosis (MS) symptoms. �
Through new treatment technologies, scientists are starting to create new ways to open up the blood-brain barrier to allow drugs and/or medications to reach the brain without interfering with its functions. Although numerous challenges probably still lie ahead, many scientists are becoming hopeful that new knowledge on the structure of the blood-brain barrier will one day lead to better treatments for several of the most challenging brain health issues. �
After the discoveries Paul Ehrlich during the late 1800s, a collection of experiments started to help demonstrated how the brain regulates what to permit passage to and what to block from entering its blood vessels. The brain is protected by the blood-brain barrier, however, this security system can frequently prevent drugs and/or medications from being able to effectively treat brain health issues. Scientists have started working towards developing successful ways to allow treatments to penetrate the blood-brain barrier.�- Dr. Alex Jimenez D.C., C.C.S.T. Insight
Neurotransmitter Assessment Form
The following Neurotransmitter Assessment Form can be filled out and presented to Dr. Alex Jimenez. The following symptoms listed on this form are not intended to be utilized as a diagnosis of any type of disease, condition, or any other type of health issue. �
Our brain is protected by the blood-brain barrier, a connection of blood vessels that permits the passage of important nutrients while blocking other compounds. However, this security system is so efficient at guarding the brain that it can frequently prevent many drugs and/or medications from being able to effectively treat a variety of brain health issues. Scientists are working towards developing ways to allow treatments to penetrate the blood-brain barrier. �
The brain depends on a variety of precise communication signals from the nerve cells to perform many fundamental functions. And it’s surrounding environment must remain stable to successfully send and receive transmissions. During the late 1800s, the outcome measures of a research study on the brain started a collection of experiments that demonstrated how the brain ultimately protects itself from the natural changes that happen in the body. �
The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.�
Curated by Dr. Alex Jimenez �
References:
Bates, Mary. �The Blood-Brain Barrier.� BrainFacts.org, 2 July 2014, www.brainfacts.org/brain-anatomy-and-function/anatomy/2014/blood-brain-barrier.
Additional Topic Discussion: Chronic Pain
Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals, however, chronic pain is different than the average type of pain. With chronic pain, the human body will continue sending pain signals to the brain, regardless if the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient’s mobility and it can reduce flexibility, strength, and endurance. �
Neural Zoomer Plus for Neurological Disease
�
Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual�s reactivity to 48 neurological antigens with connections to a variety of neurologically related diseases. The Vibrant Neural ZoomerTM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention. �
Food Sensitivity for the IgG & IgA Immune Response
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Dr. Alex Jimenez utilizes a series of tests to help evaluate health issues associated with food sensitivities. The Food Sensitivity ZoomerTM is an array of 180 commonly consumed food antigens that offers very specific antibody-to-antigen recognition. This panel measures an individual�s IgG and IgA sensitivity to food antigens. Being able to test IgA antibodies provides additional information to foods that may be causing mucosal damage. Additionally, this test is ideal for patients who might be suffering from delayed reactions to certain foods. Utilizing an antibody-based food sensitivity test can help prioritize the necessary foods to eliminate and create a customized diet plan around the patient�s specific needs. �
Gut Zoomer for Small Intestinal Bacterial Overgrowth (SIBO)
Dr. Alex Jimenez utilizes a series of tests to help evaluate gut health associated with small intestinal bacterial overgrowth (SIBO). The Vibrant Gut ZoomerTM offers a report that includes dietary recommendations and other natural supplementation like prebiotics, probiotics, and polyphenols. The gut microbiome is mainly found in the large intestine and it has more than 1000 species of bacteria that play a fundamental role in the human body, from shaping the immune system and affecting the metabolism of nutrients to strengthening the intestinal mucosal barrier (gut-barrier). It is essential to understand how the number of bacteria that symbiotically live in the human gastrointestinal (GI) tract influences gut health because imbalances in the gut microbiome may ultimately lead to gastrointestinal (GI) tract symptoms, skin conditions, autoimmune disorders, immune system imbalances, and multiple inflammatory disorders. �
Formulas for Methylation Support
XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly,�Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic�Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
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For your convenience and review of the XYMOGEN products please review the following link. *XYMOGEN-Catalog-Download �
* All of the above XYMOGEN policies remain strictly in force. �
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