Back Clinic Functional Medicine Team. Functional medicine is an evolution in the practice of medicine that better addresses the healthcare needs of the 21st century. By shifting the traditional disease-centered focus of medical practice to a more patient-centered approach, functional medicine addresses the whole person, not just an isolated set of symptoms.
Practitioners spend time with their patients, listening to their histories and looking at the interactions among genetic, environmental, and lifestyle factors that can influence long-term health and complex, chronic disease. In this way, functional medicine supports the unique expression of health and vitality for each individual.
By changing the disease-centered focus of medical practice to this patient-centered approach, our physicians are able to support the healing process by viewing health and illness as part of a cycle in which all components of the human biological system interact dynamically with the environment. This process helps to seek and identify genetic, lifestyle, and environmental factors that may shift a person’s health from illness to well-being.
The body requires energy to move around and get to places as fast as possible. The primary energy source is the blood glucose in the body, which helps provide power for the body and the brain, muscle cell tissues, and the blood cells that travel to each body’s organs. When disruptive forces start to affect the body, like chronic stress, endocrine disruptors, or lifestyle choices, it can cause the glucose levels to either increase or decrease depending on the severity. When glucose levels become too high, it can cause hyperglycemia or diabetes to develop. When they are too low, it can cause hypoglycemia. The body also suffers when there aren’t enough nutrients, minerals, or vitamins to provide energy to the body as symptoms of fatigue and insulin resistance begin to rise. Fortunately, there are ways to boost the body’s glucose levels naturally. Today’s article focus on a mineral known as magnesium, its benefits, and how it affects insulin resistance in the body. Refer patients to certified, skilled providers specializing in endocrine treatments for individuals with insulin resistance. We guide our patients by referring to our associated medical providers based on their examination when it’s appropriate. We find that education is critical for asking insightful questions to our providers. Dr. Alex Jimenez DC provides this information as an educational service only. Disclaimer
Can my insurance cover it? Yes, it may. If you are uncertain, here is the link to all the insurance providers we cover. If you have any questions or concerns, please call Dr. Jimenez at 915-850-0900.
What Is Magnesium?
Have you been feeling weird pins and needles sensations in certain parts of your body? Are you suffering from chronic fatigue and muscle cramps? Have you lost your sense of appetite? Or have you felt muscle spasms in your arms or legs? Many of these symptoms are signs that your body is suffering from low levels of magnesium in your body. Research studies have defined magnesium as the fourth most common mineral in the body that provides fundamental functions for regulation. Magnesium can be found in certain foods like leafy greens, chocolate, nuts, fruits, and meats that are riched with this mineral and can be regulated in homeostasis in the intestines, kidneys, and bones in the body. Additional research studies have shown that magnesium is essential for maintaining the body’s normal organ and cellular function. Magnesium also ensures that each organ functions normally and is transported through the entire body by the blood cells. Magnesium also plays a vital role in the body’s energy production as it helps regulate glycemic control.
What Are Its Benefits?
As the fourth common mineral in the body, magnesium helps the body in many ways as it provides energy to other organs and body systems. Some of the benefits that magnesium provides, as research has shown, include:
Reducing insomnia
Prevent metabolic syndrome
Reduce migraines and headaches
Helps with pregnancies
Reduce asthmatic symptoms
Relieve muscle cramps
Additional information has shown that magnesium can help those with anxiety by modulating the HPA (hypothalamic pituitary adrenal) axis and substrating the stress response system in the body. Magnesium also plays a role when it comes to glucose levels in the body and affects insulin resistance.
An Overview Of Magnesium & Insulin Resistance-Video
Are you feeling migraines and headaches popping up out of nowhere? Have your muscles started to ache and cramped? Have you been experiencing asthmatic symptoms more frequently? Or have your blood glucose levels begun to rise? If you have been suffering from any of these symptoms, you could suffer from magnesium deficiency. The video above explains what happens when the body is experiencing insulin resistance due to magnesium deficiency. Research studies have found that magnesium deficiency is not uncommon worldwide, as early signs of magnesium deficiency can cause nausea, vomiting, and weakness in the body while causing metabolic syndrome and type 2 diabetes. Surprisingly, diabetes is one of the most common causes of magnesium deficiency and insulin resistance.
How Does Magnesium Affect Insulin Resistance?
Research studies have found that magnesium deficiency in the body can increase the risk of insulin resistance and cause the body to become dysfunctional. When metabolic imbalances are associated with trending low or alert, low magnesium levels in the body, it can increase the serum CRP-hs, cause headaches, weight gain, and an increased risk for metabolic syndrome, insulin resistance, and type 2 diabetes. The intestines will be impaired in intestinal absorption while the blood glucose levels will increase and cause type 2 diabetes to form. However, additional information has also been provided that when an individual begins to take magnesium regularly, it can help dampen the effects of insulin resistance by regulating the blood glucose levels in the body. Many individuals with pre-existing diabetes can take a bit of magnesium to improve their blood glucose levels and continue on their health journey.
Conclusion
Incorporating supplements and minerals like magnesium could help lower the risk of insulin resistance and manage type 2 diabetes. The body needs the energy to function normally and move around constantly. Magnesium is a common mineral that can help regulate the organ’s functions and helps regulate blood glucose levels. When the body starts to suffer from magnesium deficiency, it can cause various issues that can make a person miserable while the body starts to become dysfunctional. Incorporating magnesium as part of a healthy lifestyle for the body can provide the necessary energy that a person needs to function and help them along their health and wellness journey.
References
Al Alawi, Abdullah M, et al. “Magnesium and Human Health: Perspectives and Research Directions.” International Journal of Endocrinology, Hindawi, 16 Apr. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC5926493/.
Boyle, Neil Bernard, et al. “The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review.” Nutrients, MDPI, 26 Apr. 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5452159/.
Kostov, Krasimir. “Effects of Magnesium Deficiency on Mechanisms of Insulin Resistance in Type 2 Diabetes: Focusing on the Processes of Insulin Secretion and Signaling.” International Journal of Molecular Sciences, MDPI, 18 Mar. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6470576/.
As the world is in constant motion, many people have to endure stressful situations affecting their bodies and health. The body needs hormones like cortisol to keep functioning as it affects the immune, nervous, cardiovascular, and musculoskeletal systems, to name a few. Another essential function the body needs is glucose, which requires energy to be in constant motion. Situations that cause the cortisol levels and glucose levels to rise in the body can lead to chronic issues like diabetes and chronic stress. This causes the individual to be miserable and be in a serious situation if it is not controlled right away. Today’s article examines how cortisol and glucose affect the body and the interwoven connection between stress and diabetes. Refer patients to certified, skilled providers specializing in stress management and endocrine treatments for diabetic individuals. We guide our patients by referring to our associated medical providers based on their examination when it’s appropriate. We find that education is critical for asking insightful questions to our providers. Dr. Alex Jimenez DC provides this information as an educational service only. Disclaimer
Can my insurance cover it? Yes, it may. If you are uncertain, here is the link to all the insurance providers we cover. If you have any questions or concerns, please call Dr. Jimenez at 915-850-0900.
How Does Cortisol Affect The Body?
Have you been experiencing sleeping problems at night? What about frequent headaches that are a nuisance throughout the entire day? Or have you noticed excessive weight loss or weight gain around your midsection? Some of these symptoms are signs that your cortisol and glucose levels are high and can affect your body. Cortisol is a hormone produced in the endocrine system and can be beneficial or harmful to the body if it is not regularly checked. Research studies have defined cortisol as one of the prominent glucocorticoids secreted out due to the response of the body’s biochemicals, characterized by the HPA (hypothalamic‐pituitary‐adrenal) axis helps cognitive events. However, when the cortisol levels turn chronic in the body due to circumstances that cause the body to become dysfunctional, it can significantly impact a person and cause an imbalance in the HPA axis. Some of the symptoms that chronic cortisol leads to the body can include:
Hormonal imbalances
Insulin resistance
Weight gain
Increases in visceral “belly” fat
Increased cortisol output
Immune problems
Allergies and Asthma
Inflamed Joints
Poor exercise recovery
Additional information has provided that the presence of cortisol in the body can help increase blood glucose availability to the brain. With cortisol providing organ functionality, the blood glucose provides energy for the body.
How Cortisol & Glucose Work In The Body
Cortisol helps stimulate mass glucose mobilization in the liver, allowing block protein synthesis to push amino acids into sugar for the body. This is known as fatty acid liberation biotransformed into glucose. When this happens, it helps stimulate visceral fat storage if excess glucose is not utilized, thus causing weight gain. Research studies have shown that a lack of cortisol can cause a decrease in hepatic glucose production in the body. This will cause hypoglycemia, where the body doesn’t have enough glucose in its system. Additional research shows that cortisol responds to any stressor that affects a person with low glucose levels but can also become positive after a glucose load. Managing the body’s glucose and cortisol levels can help progress the development of diabetes.
How Cortisol Is Linked With Type 2 Diabetes- Video
Have you experienced stressful situations that cause your muscles to tense up? How about feeling your blood sugar either spiking up or down? Do you feel inflammatory effects all over your body that makes them ache? Stress can cause harmful effects to the body, activating inflammation, increasing sympathetic tone, and reducing glucocorticoid responsiveness. Stress can also be linked to diabetes, as the video above shows how the stress hormone cortisol is linked with type 2 diabetes. Research studies have mentioned that cortisol can become negatively associated with the mechanics of insulin resistance, increasing the beta-cell function and increasing the insulin released in the body. This can become dangerous for many individuals that have pre-existing diabetes and have been dealing with stress constantly.
The Interwoven Connection Between Stress & Diabetes
The interwoven connection between stress and diabetes is shown as research studies have found that the pathophysiology of anxiety and diabetes has increased insulin resistance risk for the body. When a person is dealing with chronic stress, it can cause them to have many issues like:
Cold intolerance
Diminished cognition and mood
Food sensitivities
Low energy throughout the day
When this happens, the body is at a high risk of developing insulin resistance and type 2 diabetes. Research studies have mentioned that type 2 diabetes is characterized by insulin resistance and beta-cell dysfunction. The glucocorticoid in the body can become excessive to affect the cells, causing dysfunctionality. Additional research studies have shown that any perceived stress can become a vital risk factor that not only affects the body, like hypertension, BMI (body mass index), or diet quality but can cause a rise in type 2 diabetes. When individuals find ways to lower their chronic stress, it can help manage their glucose levels from reaching critical levels.
Conclusion
The body’s chronic stress can cause insulin resistance and cause diabetes to become pre-existing. The body needs cortisol and glucose to keep functioning and have the energy to move. When people start to suffer from chronic stress and diabetes, it can become challenging to manage; however, making minor changes to the body like finding ways to lower stress, eating healthy foods, and monitoring glucose levels can help the body reset the glucose and cortisol levels to normal. Doing this can relieve many individuals who want to continue their health journey being stress-free.
References
Adam, Tanja C, et al. “Cortisol Is Negatively Associated with Insulin Sensitivity in Overweight Latino Youth.” The Journal of Clinical Endocrinology and Metabolism, The Endocrine Society, Oct. 2010, www.ncbi.nlm.nih.gov/pmc/articles/PMC3050109/.
De Feo, P, et al. “Contribution of Cortisol to Glucose Counterregulation in Humans.” The American Journal of Physiology, U.S. National Library of Medicine, July 1989, pubmed.ncbi.nlm.nih.gov/2665516/.
Hucklebridge, F H, et al. “The Awakening Cortisol Response and Blood Glucose Levels.” Life Sciences, U.S. National Library of Medicine, 1999, pubmed.ncbi.nlm.nih.gov/10201642/.
Joseph, Joshua J, and Sherita H Golden. “Cortisol Dysregulation: The Bidirectional Link between Stress, Depression, and Type 2 Diabetes Mellitus.” Annals of the New York Academy of Sciences, U.S. National Library of Medicine, Mar. 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5334212/.
Kamba, Aya, et al. “Association between Higher Serum Cortisol Levels and Decreased Insulin Secretion in a General Population.” PloS One, Public Library of Science, 18 Nov. 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC5115704/.
Lee, Do Yup, et al. “Technical and Clinical Aspects of Cortisol as a Biochemical Marker of Chronic Stress.” BMB Reports, Korean Society for Biochemistry and Molecular Biology, Apr. 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC4436856/.
Thau, Lauren, et al. “Physiology, Cortisol.” In: StatPearls [Internet]. Treasure Island (FL), StatPearls Publishing, 6 Sept. 2021, www.ncbi.nlm.nih.gov/books/NBK538239.
The skin and the gut have a unique connection. The gut system is home to trillions of microorganisms that help metabolize the body’s homeostasis while keeping the immune system functioning for the body to be working correctly. The skin has its set of functions as well as it is the largest organ and helps protect the body from external factors from harm. When these disruptive factors start to affect either the gut or the skin, it can lead to numerous conditions that cause the body to be dysfunctional. When the gut becomes affected by these disruptive factors, it can cause gut disorders and inflammation, affecting the skin and causing disruptions. Today’s article will discuss a skin disorder known as psoriasis and how the gut-skin connection is affected by psoriasis. Referring patients to certified, skilled providers who specialize in gastroenterology treatments. We provide guidance to our patients by referring to our associated medical providers based on their examination when it’s appropriate. We find that education is critical for asking insightful questions to our providers. Dr. Alex Jimenez DC provides this information as an educational service only. Disclaimer
Can my insurance cover it? Yes, it may. If you are uncertain, here is the link to all the insurance providers we cover. If you have any questions or concerns, please call Dr. Jimenez at 915-850-0900.
What Is Psoriasis?
Do you have severe itching along your face and arms? Do certain foods seem to aggravate your digestive tract or skin? Or have you experienced any gut disorders that are affecting your wellbeing? Many of these symptoms are signs of inflammatory issues affecting the gut and are associated with a skin disorder known as psoriasis. Research studies have defined psoriasis as a chronic inflammatory skin disease that is an autoimmune process in which abnormal differentiation and hyper-proliferation of the epidermis occur with redness and scaling. Psoriasis affects about 2% of the general population in the world and is an autoimmune process driven by abnormally activated helper T cells. Additional studies have mentioned that psoriasis is sustained by inflammation that causes the keratinocyte proliferation to be uncontrollable and has dysfunctional differentiation. The inflammatory pathways activate psoriasis in different body locations, causing the individual to become miserable because they are itching and becoming miserable.
An Overview Of Psoriasis-Video
Do you have scaly, patchy lesions in certain areas of your body? Do you feel any gut issues affecting you constantly? Do you feel inflammatory effects disrupting your gut and skin? Many of these conditions are signs that you are experiencing gut disorders associated with a skin disorder known as psoriasis. The video above explains how the gut and skin are affected due to psoriasis and how to heal it naturally. Research studies have mentioned that when the individual is suffering from psoriasis-prone skin, it is due to the alternation of the gut microbiota. When a person scratches the area where psoriasis is formed, it might damage the skin and cause the bacteria to colonize while invoking inflammation to occur in the affected area. Additional research has found that gut disorders like IBD (inflammatory bowel disease) and psoriasis are interlinked due to the increased interaction of inflammatory receptor pathogens disrupting the body’s immune cells.
How The Gut-Skin Connection Is Affected By Psoriasis
The gut is home to trillions of microorganisms that help metabolize the body’s homeostasis while regulating the immune system. Since the body inhabits microorganisms in various locations, including the skin and gut, it helps maintain homeostasis. The skin helps protect the body from external factors and has bidirectional communication with the gut system. However, like with any autoimmune process, it always starts with the gut. Research studies have mentioned that psoriasis is a multifactorial chronic skin disease that infiltrates the body’s immune cells, causing an increase in skin inflammation and making a person’s life miserable. With the gut system also being inflicted by inflammatory markers, many suffering individuals will experience IBD, SIBO, and other gut disorders that can disrupt the body. Additional information has shown that changes in the microflora in the gut-skin axis from genetic or environmental factors can contribute to various diseases. But when these factors begin to cause an increase in inflammatory markers in the body, it can affect a person’s quality of life through habits that make them miserable.
Conclusion
The body needs the gut and skin to maintain homeostasis and metabolize the immune system. The gut microbiota helps transport the nutrients that the body needs and regulates the body’s immunity, while the skin protects the body from outside factors while being the largest organ. The gut and skin have a bi-directional connection that allows them to keep the body from suffering from dysbiosis. When disruptive factors affect either the gut or the skin, it can lead to many disorders and make a person’s life miserable. The skin suffers from a condition known as psoriasis, a chronic inflammatory disease that causes itchy, patchy lesions that can affect the areas around the body. Psoriasis is associated with gut disorders, as many factors aggravate the inflammatory markers and can be a nuisance if not treated early. Incorporating small changes that benefit both the gut and skin health can help relieve the individual from psoriasis and bring back their quality of life.
References
Chen, Lihui, et al. “Skin and Gut Microbiome in Psoriasis: Gaining Insight into the Pathophysiology of It and Finding Novel Therapeutic Strategies.” Frontiers in Microbiology, Frontiers Media S.A., 15 Dec. 2020, www.ncbi.nlm.nih.gov/pmc/articles/PMC7769758/.
De Francesco, Maria Antonia, and Arnaldo Caruso. “The Gut Microbiome in Psoriasis and Crohn’s Disease: Is Its Perturbation a Common Denominator for Their Pathogenesis?” Vaccines, MDPI, 5 Feb. 2022, www.ncbi.nlm.nih.gov/pmc/articles/PMC8877283/.
Ellis, Samantha R, et al. “The Skin and Gut Microbiome and Its Role in Common Dermatologic Conditions.” Microorganisms, MDPI, 11 Nov. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6920876/.
Nair, Pragya A, and Talel Badri. “Psoriasis.” In: StatPearls [Internet]. Treasure Island (FL), StatPearls Publishing, 6 Apr. 2022, www.ncbi.nlm.nih.gov/books/NBK448194/.
Olejniczak-Staruch, Irmina, et al. “Alterations of the Skin and Gut Microbiome in Psoriasis and Psoriatic Arthritis.” International Journal of Molecular Sciences, MDPI, 13 Apr. 2021, www.ncbi.nlm.nih.gov/pmc/articles/PMC8069836/.
Rendon, Adriana, and Knut Schäkel. “Psoriasis Pathogenesis and Treatment.” International Journal of Molecular Sciences, MDPI, 23 Mar. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6471628/.
The skin is the largest organ in the body and encounters numerous factors that can either benefit or harm the body. The skin helps protect the organs and intestines in the gut system, keeps the musculoskeletal system structure functional, and even helps the nervous system send out signals for motor-sensory functions to the rest of the body. The skin is associated with the gut system as the gut microbiota host trillions of beneficial gut flora that send out nutrients to help promote tissue growth, improve the body’s immunity, and metabolize skin health by protecting it from disruptive pathogens. When these pathogens cause inflammatory issues in the gut system, it can affect the body’s skin, brain, and immune health by making them dysfunctional. Today’s article will look at a skin condition known as atopic dermatitis, how it affects the gut-skin system, and what treatments are available for relieving gut issues and atopic dermatitis in individuals. Referring patients to certified, skilled providers who specialize in gastroenterology treatments. We provide guidance to our patients by referring to our associated medical providers based on their examination when it’s appropriate. We find that education is critical for asking insightful questions to our providers. Dr. Alex Jimenez DC provides this information as an educational service only. Disclaimer
Can my insurance cover it? Yes, it may. If you are uncertain, here is the link to all the insurance providers we cover. If you have any questions or concerns, please call Dr. Jimenez at 915-850-0900.
What Is Atopic Dermatitis?
Have you experienced inflammation around your gut or in certain areas of your skin? Do issues like SIBO, IBD, leaky gut, or bloating become more frequent? Do certain foods trigger inflammatory markers in your skin and gut? The numerous signs and symptoms are due to a skin disorder known as atopic dermatitis. Atopic dermatitis or eczema is a pruritic, hereditary skin disorder. The lifetime prevalence is 10% to 20%, with many cases starting as a baby and rising to 20% to 40% as adults continue to have atopic dermatitis. Research studies have defined atopic dermatitis as one of the most common skin diseases that cause chronic inflammation in the skin. The pathophysiology of atopic dermatitis is both complex and multifactorial. It involves the elements of barrier dysfunction, alterations in cell-mediated immune responses, IgE-mediated hypersensitivity, and environmental factors that cause flare-ups. Additional research studies have mentioned that the pathology of atopic dermatitis is being looked at as the skin’s structural abnormalities and immune dysregulation play their roles as this condition progress. Other genetic changes have also been identified, altering the skin’s barrier function, resulting in an atopic dermatitis phenotype. The imbalance of Th2 to Th1 cytokines is observed as it alters cell-mediated immune responses. Atopic dermatitis can promote IgE-mediated hypersensitivity in the skin as part of its development. This can also be due to the environmental factors that be the causing development of atopic dermatitis.
How Does It Affect The Gut-Skin Connection?
Since atopic dermatitis is a chronic inflammatory skin disease, many factors do come to play in its development. For example, food allergies cause atopic dermatitis in 25% to 50% of children. Some of the food allergens that are commonly linked to atopic dermatitis include:
Eggs
Soy
Milk
Wheat
Fish
Shellfish
Peanuts
One of the other factors that can cause the development of atopic dermatitis is gut issues. Research studies have shown that any alterations in the gut microbiome due to atopic dermatitis affect the immune system balance in the body. When the gut microbiome becomes altered, it affects metabolite production and reduces the body’s immune system. When bacteria overgrowth in the GI tract, it has been suggested as a causative factor in allergic diseases, including atopic dermatitis. Another factor is when individuals consume trans fats, which increase the development of atopic dermatitis since they interfere with the metabolism and use of essential fatty acids.
The Microbiome Of Atopic Dermatitis-Video
Have you experienced inflammation in your digestive tract or particular areas of your skin? Does your body feel fatigued constantly? Do you have any gut issues or disorders that are affecting your health? Most of these symptoms are signs that you are experiencing atopic dermatitis caused by gut issues. Research studies have found that various factors can trigger atopic dermatitis, affect the immune system, and disrupt the gut microbiota. The video above explains the microbiome in atopic dermatitis and how it affects the gut, skin, and the entire body. Luckily there are available treatments to relieve atopic dermatitis and gut disorders from wreaking havoc on the body.
Treatments For Relieving Atopic Dermatitis & The Gut
When a person begins to find treatments for relieving atopic dermatitis usually involves:
Early diagnosis.
Skin barrier function support.
Mitigation of cutaneous inflammation.
Concomitant risk stratification
Another way that many individuals can alleviate atopic dermatitis is with a healthy GI tract. This will help many individuals suffering from a food allergy, asthma, allergic rhinitis, and environmental allergies to relieve atopic dermatitis from progressing further. A study showed that probiotics and prebiotics are essential in preventing food allergies and eczema. Probiotics and prebiotics help replenish the beneficial bacteria in the gut and regulate the immune system. This prevents atopic dermatitis from stopping progressing and restor the body back.
Conclusion
Many factors cause atopic dermatitis progression to become severe, as it is crucial to find the root cause of the flare-ups and alleviate them at the source. Overall having gut issues associated with atopic dermatitis is no laughing matter. When the gut microbiome is being affected by inflammatory disorders, it can disrupt the immune system and cause atopic dermatitis to develop on the skin. Incorporating probiotics and prebiotics can help replenish the gut bacteria and figure out what causes the inflammatory symptoms to spike up from certain foods will benefit the gut and the skin to become healthier.
References
Fang, Zhifeng, et al. “Gut Microbiota, Probiotics, and Their Interactions in Prevention and Treatment of Atopic Dermatitis: A Review.” Frontiers in Immunology, Frontiers Media S.A., 14 July 2021, www.ncbi.nlm.nih.gov/pmc/articles/PMC8317022/.
Kapur, Sandeep, et al. “Atopic Dermatitis.” Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology, BioMed Central, 12 Sept. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6157251/.
Kim, Jung Eun, and Hei Sung Kim. “Microbiome of the Skin and Gut in Atopic Dermatitis (AD): Understanding the Pathophysiology and Finding Novel Management Strategies.” Journal of Clinical Medicine, MDPI, 2 Apr. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6518061/.
Kolb, Logan, and Sarah J Ferrer-Bruker. “Atopic Dermatitis – Statpearls – NCBI Bookshelf.” In: StatPearls [Internet]. Treasure Island (FL), StatPearls Publishing, 13 Aug. 2021, www.ncbi.nlm.nih.gov/books/NBK448071/.
Lee, So Yeon, et al. “Microbiome in the Gut-Skin Axis in Atopic Dermatitis.” Allergy, Asthma & Immunology Research, The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease, July 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6021588/.
The body is always going through many factors that constantly test the durability that can affect the entire microbiome itself. The gut helps the body’s homeostasis by metabolizing the nutrients that provide the energy for functionality. The gut system is home to trillions of microorganisms that communicate to the brain system, endocrine system, immune system, and skin to ensure that it is healthy. When disruptive factors enter the gut system, they can cause various issues that can make the dysfunctional body while affecting its communication with the body’s axis. Today’s article focuses on a skin condition that everyone has suffered in their lives known as acne and how the gut-skin axis is being affected by acne. Referring patients to certified, skilled providers who specialize in gastroenterology treatments. We provide guidance to our patients by referring to our associated medical providers based on their examination when it’s appropriate. We find that education is critical for asking insightful questions to our providers. Dr. Alex Jimenez DC provides this information as an educational service only. Disclaimer
Can my insurance cover it? Yes, it may. If you are uncertain, here is the link to all the insurance providers we cover. If you have any questions or concerns, please call Dr. Jimenez at 915-850-0900.
What Is Acne Vulgaris?
Have you noticed bumps along your face, especially in the nose, forehead, and cheek regions? How about inflammatory reactions that are affecting your skin? Do issues like GERD, IBS, leaky gut, or SIBO affect your gut? Most of these issues are due to disruptive factors that affect the gut-skin connection and cause a skin condition known as acne vulgaris. Everybody suffers from acne when they are young, and it is a common condition with follicular papules or comedones and inflammatory papules and pustules. Research studies have shown that acne vulgaris is an inflammatory disorder triggered by many factors that can cause it to become aggravated and inflamed. Some of the contributing factors that can cause acne vulgaris to form due to the following:
Infection (Propionibacterium acnes)
Tissue inflammation
Plugging of hair follicles due to epidermal hyperproliferation
Hormone imbalance
Endocrine disorders
Excess sun exposure
Other research studies have shown that other factors like gut disorders can also affect the development of acne vulgaris. Acne vulgaris can be associated with the emotional factors that affect the brain and the gut’s inflammatory factors as they go hand in hand. When a person becomes stressed or anxious, their skin will flare up and develop acne around some skin regions. Additional studies have mentioned that emotional factors like stress and anxiety can alter the gut microbiota and increase intestinal permeability. When gut disorders start to contribute to skin inflammation, it can aggravate acne to develop and form on the skin.
Gut Health & Acne- Video
Have you experienced gut disorders that seem to affect your quality of life? Have you noticed that particular foods you consume are not sitting well in your gut system? How about feeling overly stressed and anxious that acne forms around your face? The video above explains how the gut microbiome affects a person when making dietary changes that can provide beneficial results to the gut microbiota. Research studies have found that the intestinal microbiota is essential for forming acne lesions while being responsible for proper immunity and defense of the microorganisms. The GI tract and acne condition are closely associated because they provide the neuroendocrine and immune functions to the body.
The Gut-Skin Axis & How It Affects Acne
Since the gut is the host to trillions of bacteria, its primary job is to maintain constant communication with the skin to dampen unnecessary inflammatory markers that can cause the skin to break out. Research studies have found that the gut-skin axis, when affected by acne, produces significantly higher metabolites that generate ROS (reactive oxygen species) and induce inflammation in both the gut and skin. Additional research has shown that the gut microbiome plays an essential role in skin disorders and vice versa. When changes affect either the gut or the skin, it can drastically change a person’s outcome in life. Say, for instance, dietary habits that cause inflammation in the gut. This is due to processed foods that cause the gut to become inflamed and make the skin begin the development of acne in different portions of the skin. Research shows that the gut microbiome can vastly influence the immune system by regulating it. This builds a tolerance to dietary changes in the gut to promote acne-free skin. So incorporating a low-glycemic-load diet has been linked to improved acne, possibly through gut changes or attenuation of insulin levels.
Conclusion
Overall, the gut plays a massive role in the body in its homeostasis as it helps the body metabolize the nutrients to keep it functioning and moving. The gut microbiota also has bidirectional communication with the skin as common skin disorders like acne tend to show up. Acne is very common amongst individuals, especially in younger individuals, as it can affect their moods and cause changes to their mental health and their gut health. Incorporating small changes like eating healthy food, maintaining a stress-free environment, and even exercising can help not only lower gut inflammation but also clear up the skin from acne.
References
Bowe, Whitney P, and Alan C Logan. “Acne Vulgaris, Probiotics and the Gut-Brain-Skin Axis – Back to the Future?” Gut Pathogens, BioMed Central, 31 Jan. 2011, www.ncbi.nlm.nih.gov/pmc/articles/PMC3038963/.
Chilicka, Karolina, et al. “Microbiome and Probiotics in Acne Vulgaris-A Narrative Review.” Life (Basel, Switzerland), MDPI, 15 Mar. 2022, www.ncbi.nlm.nih.gov/pmc/articles/PMC8953587/.
De Pessemier, Britta, et al. “Gut-Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions.” Microorganisms, MDPI, 11 Feb. 2021, www.ncbi.nlm.nih.gov/pmc/articles/PMC7916842/.
Lee, Young Bok, et al. “Potential Role of the Microbiome in Acne: A Comprehensive Review.” Journal of Clinical Medicine, MDPI, 7 July 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6678709/.
Salem, Iman, et al. “The Gut Microbiome as a Major Regulator of the Gut-Skin Axis.” Frontiers in Microbiology, Frontiers Media S.A., 10 July 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6048199/.
Sutaria, Amita H, et al. “Acne Vulgaris.” In: StatPearls [Internet]. Treasure Island (FL), StatPearls Publishing, 8 May 2022, www.ncbi.nlm.nih.gov/books/NBK459173/.
As everyone knows, the gut helps the body metabolize nutrients and vitamins that it needs to function correctly. The gut system also allows the body’s immunity to perform while staying in communication with the brain. The gut helps sends signals back and forth to regulate the body’s hormones signals and other beneficial substances that the body requires. The gut is also in communication with the largest organ in the body, which is the skin. When intolerable factors start to wreck the gut and cause chaos inside the gut system, it disrupts the brain signals in the nervous system and can also take a toll on the skin. Today’s article will focus on a skin condition known as rosacea, how it affects the gut system, and what is the gut-skin connection. Referring patients to certified, skilled providers who specialize in gastroenterology treatments. We provide guidance to our patients by referring to our associated medical providers based on their examination when it’s appropriate. We find that education is critical for asking insightful questions to our providers. Dr. Alex Jimenez DC provides this information as an educational service only. Disclaimer
Can my insurance cover it? Yes, it may. If you are uncertain, here is the link to all the insurance providers we cover. If you have any questions or concerns, please call Dr. Jimenez at 915-850-0900.
What Is Rosacea?
Have you felt any gut disorders like IBS, leaky gut, or GERD affecting your mid-section? How about redness around your face, especially the nose and cheek areas? Does your skin seem to feel tender to the touch in certain areas? Most of these symptoms are related to a chronic inflammatory disease known as rosacea. It is usually indicated by genetic and environmental components that can trigger rosacea initiation on the skin. Rosacea is generally aggravated by dysregulation of the body’s innate and adaptive immune system. Research studies have mentioned that rosacea is usually developed by lymphatic dilation and blood vessels exposed to extreme temperatures, spices, or alcohol which causes rosacea to affect the cheeks and nose. Not only that, but genetics, immune reaction, microorganisms, and environmental factors lead to various mediators such as keratinocytes, endothelial cells, mast cells, macrophages, T helper type 1 (TH1), and TH17 cells.
How Does It Affect The Gut System?
Since rosacea is developed through exposure to high temperatures, spices, or alcohol, research studies have shown that particular food and drinks cause the inflammatory cytokines to become triggered in the face. Additionally, many trigger factors can directly communicate to the cutaneous nervous system; neurovascular and neuro-immune active neuropeptides are lead to the manifestation of rosacea lesions. Some of the other triggers that can cause rosacea to develop is an unhealthy gut system. A study showed that more than 50% had low stomach acid among patients who had both rosacea and dyspepsia. The bacteria H.pylori resides in the stomach and has been recognized to trigger inflammation and gastrin-induced flushing, thus causing rosacea. Additional studies have mentioned that rosacea individuals will experience some gut disorders to occur. Since the gut system can succumb to various factors, it can affect the gut’s composition and trigger rosacea. Since the gut microbiota has influenced the body’s homeostasis, it can also influence the skin. When there are factors that trigger the intestinal barrier of the gut, it can affect the skin, causing the inflammatory cytokines to proceed with the development of rosacea.
Uncovering The Gut-Skin Connection-Video
Does your skin feel flushed due to extreme temperatures or consuming spicy food? Have you experienced gut disorders like SIBO, GERD, or leaky gut? Has your skin seemed to break out even more than it should? Your skin could be affected by your gut microbiota, as the video above shows what the gut-skin connection is and how they work with each other. Research studies have shown that since the gut microbiome is the key regulator of the body’s immune system, it plays a vital role in various skin disorders. This means that when environmental factors affect the gut’s microbiome, it also affects the skin through dysbiosis.
What Is The Gut-Skin Connection?
As stated earlier, the gut system is home to trillions of microorganisms that help metabolize the body’s homeostasis, including the largest organ, the skin. Research studies have found that when the gut microbial and the skin communicate with each other. It creates a bidirectional connection. The gut microbiome is also an essential mediator of inflammation in the gut and affects the skin. When there are factors like insulin resistance, imbalances in the sex hormones, gut inflammation, and microbial dysbiosis wrecking the gut system, the effects can cause the pathology of many inflammatory disorders to affect the skin. Any changes to the gut can also affect the skin as the gut consumes food to be biotransformed into nutrients that the body needs. But when food allergies and sensitivities affect the gut, the skin also gets involved, causing skin disorders like rosacea.
Conclusion
Overall the gut makes sure that the body is functioning correctly by metabolizing nutrients from consumed foods. The gut system has a connection to not only the brain and immune system but also the skin. The gut-skin connection goes hand in hand as factors that affect the gut can also affect the skin in developing skin disorders like rosacea. When a person is suffering from gut disorders, their skin is also damaged by factors like stress, food sensitivities, and skin disorders that can become a nuisance. This can be alleviated through small changes like reducing stress, eating healthy foods, and exercising, which are beneficial for relieving gut and skin disorders for individuals who want to get their health back.
De Pessemier, Britta, et al. “Gut-Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions.” Microorganisms, MDPI, 11 Feb. 2021, www.ncbi.nlm.nih.gov/pmc/articles/PMC7916842/.
Farshchian, Mehdi, and Steven Daveluy. “Rosacea.” In: StatPearls [Internet]. Treasure Island (FL), StatPearls Publishing, 30 Dec. 2021, www.ncbi.nlm.nih.gov/books/NBK557574/.
Mikkelsen, Carsten Sauer, et al. “Rosacea: A Clinical Review.” Dermatology Reports, PAGEPress Publications, Pavia, Italy, 23 June 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC5134688/.
Salem, Iman, et al. “The Gut Microbiome as a Major Regulator of the Gut-Skin Axis.” Frontiers in Microbiology, Frontiers Media S.A., 10 July 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6048199/.
The gut system is home to trillions of beneficial bacteria that helps biotransformed food into nutrients for the body to function correctly. The gut is also in constant communication with the brain as the neuron signals are in a bi-directional wavelength that helps move the nutrients to their designated areas in the body. These designated areas help the body as well, as they have their own set of instructions to work correctly while the body is in motion. When gut disorders like metainflammation start to disrupt the signals going back and forth between the brain and gut, it can cause various issues that can cause the body to become dysfunctional and progress into chronic inflammation. Today’s article discusses what metainflammation does to the gut-brain axis and how inflammasomes play their role in the gut-liver axis in the body. Referring patients to qualified, skilled providers who specialize in gastroenterology treatments. We provide guidance to our patients by referring to our associated medical providers based on their examination when it’s appropriate. We find that education is critical for asking insightful questions to our providers. Dr. Alex Jimenez DC provides this information as an educational service only. Disclaimer
Can my insurance cover it? Yes, it may. If you are uncertain, here is the link to all the insurance providers we cover. If you have any questions or concerns, please call Dr. Jimenez at 915-850-0900.
Metainflammation Affecting The Gut-Brain Axis
Have you been noticing an increase in food allergies or intolerances affecting you? How about feeling digestive problems rise on multiple occasions? Many of these symptoms are due to gut disorders like metainflammation, which can also affect the gut-brain axis in the body. Research studies have mentioned that the nervous system directly influences the gut through endocrine mediators interacting with microbial receptors. When metainflammation begins to affect the gut, it becomes the result of various gut dysbiosis like:
Increased sleep and mood disturbances
Fatigue
Decreased performance and exercise ability
Nutrient deficiencies – vitamin D, B vitamins
Thyroid imbalance
Other research studies have shown that since inflammation is a common factor for various disorders affecting the body, it can do much damage when the inflammatory cytokines affect the gut-brain axis and the immune system. Meta inflammation causes a decrease in intestinal absorption and contractility, but it can also increase the defective tight junctions and intestinal permeability. This causes gut issues like Crohn’s and celiac disease to rise, causing increased insulin and immune dysregulation and brain issues like sleep, cognition, mood disturbances, anxiety, and psychiatric disorders.
An Overview On The Gut-Brain-Axis-Video
Have you been experiencing weight gain around your mid section? How about an increase in memory and cognitive decline? Have you felt a rise in chronic inflammation or immune problems? All these symptoms are signs that you could be experiencing metainflammation that affects the gut-brain axis in your body. The video above explains the gut-brain axis and how neurodevelopment disorders can affect the brain. Research studies have found that a mixture of dysbiosis and inflammation affects the gut, and it can cause the brain to be linked to many neurological disorders. With the bi-directional connection that the brain and gut have, many factors are constantly challenging both microbiomes that can progress inflammatory markers to rise in the body.
What Are Inflammasomes?
Inflammasomes are a family of proteins in charge of initiating the inflammatory process during the innate immune response. Inflammasomes are defensive microbes that cause inflammatory effects against infections and can even affect the gut-liver axis in the body if it turns chronic. What inflammasomes does is that they help pattern recognition receptors to know when the body is feeling stressed or in danger, as they are significant actors in the metaflammation construct. Research studies have shown that inflammasomes in the body can help secrete toxins into the invading microbes causing gut disorders.
How Does Inflammasome Affect The Gut-Liver Axis?
The gut-liver axis is connected with the intestines via bile acid metabolism. Bile acid dysregulation can lead to intestinal dysbiosis, which allows the gram-negative erogenous pathogenic bacteria and LPS to enter the liver. When this happens, it triggers hepatic inflammation via inflammasomes. Research studies have shown that chronic inflammation affecting the gut-liver axis can cause the inflammasomes to affect the epithelial wall integrity and even induce pro-inflammatory cytokine production, causing more issues in the body. In contrast, the NLRP3 inflammasome primarily induces IL‐1beta by causing bile acids to activate the NLRP3 inflammasome in macrophages. This induces bacterial translocation to allow pathogens, i.e., Bacteroidetes (Gram‐negative bacteria) and LPS, into the liver.
Conclusion
Overall, the gut-brain axis allows bi-directional communication to the entire body as the gut help regulates the metabolic function of the body. At the same time, the brain controls the signals and processes that the body encounters. When chronic issues like metainflammation or chronic inflammasomes begin to affect the gut, it can disrupt the bidirectional communication to the brain, causing the body to become dysfunctional. Incorporating small changes to confident life choices like adding supplements and nutraceuticals to dampen inflammation, eating healthier, and exercising can help relieve the gut. When many individuals make these small changes in their health and wellness journey, they can feel themselves have more energy, feel less inflammation affecting their gut, and move around more.
References
Clapp, Megan, et al. “Gut Microbiota’s Effect on Mental Health: The Gut-Brain Axis.” Clinics and Practice, PAGEPress Scientific Publications, Pavia, Italy, 15 Sept. 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5641835/.
de Zoete, Marcel R, et al. “Inflammasomes.” Cold Spring Harbor Perspectives in Biology, Cold Spring Harbor Laboratory Press, 16 Oct. 2014, www.ncbi.nlm.nih.gov/pmc/articles/PMC4292152/.
Herradon, Gonzalo, et al. “Connecting Metainflammation and Neuroinflammation through the PTN-Mk-Rptpβ/ζ Axis: Relevance in Therapeutic Development.” Frontiers in Pharmacology, Frontiers Media S.A., 12 Apr. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6474308/.
Osadchiy, Vadim, et al. “The Gut-Brain Axis and the Microbiome: Mechanisms and Clinical Implications.” Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, U.S. National Library of Medicine, Jan. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6999848/.
Wang, Junfeng, et al. “Roles of the Inflammasome in the Gut‑Liver Axis (Review).” Molecular Medicine Reports, D.A. Spandidos, Jan. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6297761/.
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