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Physical Rehabilitation

Back Clinic Physical Rehabilitation Team. Physical medicine and rehabilitation, which is also known as physiatry or rehabilitation medicine. Its goals are to enhance, restore functional ability and quality of life to those with physical impairments or disabilities affecting the brain, spinal cord, nerves, bones, joints, ligaments, muscles, and tendons. A physician that has completed training is referred to as a physiatrist.

Unlike other medical specialties that focus on a medical cure, the goals of the physiatrist are to maximize the patient’s independence in activities of daily living and improve quality of life. Rehabilitation can help with many body functions. Physiatrists are experts in creating a comprehensive, patient-centered treatment plan. Physiatrists are integral members of the team. They utilize modern, as well as, tried and true treatments to bring optimal function and quality of life to their patients. And patients can range from infants to octogenarians. For answers to any questions you may have please call Dr. Jimenez at 915-850-0900


Pilates Chiropractor vs. McKenzie Chiropractor: Which is Better?

Pilates Chiropractor vs. McKenzie Chiropractor: Which is Better?

Low back pain, or LBP, is a very common condition which affects the lumbar spine, or the lower section of the spine. Approximately more than 3 million cases of LBP are diagnosed in the United States aline every year and about 80 percent of adults worldwide experience low back pain at some point during their lifetime. Low back pain is generally caused by injury to a muscle (strain) or ligament (sprain) or due to damage from a disease. Common causes of LBP include poor posture, lack of regular exercise,�improper lifting, fracture, herniated discs and/or arthritis. Most cases of low back pain may often go away on their own, however, when LBP becomes chronic, it may be important to seek immediate medical attention. Two therapeutic methods have been utilized to improve LBP. The following article compares the effects of Pilates and McKenzie training on LBP.

 

A Comparison of the Effects of Pilates and McKenzie Training on Pain and General Health in Men with Chronic Low Back Pain: A Randomized Trial

 

Abstract

 

  • Background: Today, chronic low back pain is one of the special challenges in healthcare. There is no unique approach to treat chronic low back pain. A variety of methods are used for the treatment of low back pain, but the effects of these methods have not yet been investigated adequately.
  • Aim: The aim of this study was to compare the effects of Pilates and McKenzie training on pain and general health of men with chronic low back pain.
  • Materials and Methods: Thirty-six patients with chronic low back pain were chosen voluntarily and assigned to three groups of 12 each: McKenzie group, Pilates group, and control group. The Pilates group participated in 1-h exercise sessions, three sessions a week for 6 weeks. McKenzie group performed workouts 1 h a day for 20 days. The control group underwent no treatment. The general health of all participants was measured by the General Health Questionnaire 28 and pain by the McGill Pain Questionnaire.
  • Results: After therapeutic exercises, there was no significant difference between Pilates and McKenzie groups in pain relief (P = 0.327). Neither of the two methods was superior over the other for pain relief. However, there was a significant difference in general health indexes between Pilates and McKenzie groups.
  • Conclusion: Pilates and McKenzie training reduced pain in patients with chronic low back pain, but the Pilates training was more effective to improve general health.
  • Keywords: Chronic back pain, general health, Mckenzie training, pain, Pilates training

 

Introduction

 

Low back pain with a history of more than 3 months and without any pathological symptom is called chronic low back pain. For patient with chronic low back pain, the physician should take into consideration the likelihood of muscle pain development with spinal origin, in addition to low back pain with unknown origin. This type of pain may be mechanical (increase in pain with movement or physical pressure) or nonmechanical (increase in pain at the rest time).[1] Low back pain or spine pain is the most common musculoskeletal complication.[2] About 50%�80% of healthy people may experience low back pain during their lifetime, and about 80% of the problems are related to the spine and occur in the lumbar area.[3] Low back pain may be caused by trauma, infection, tumors, etc.[4] Mechanical injuries which are caused by overuse of a natural structure, deformity of an anatomical structure, or the injury in the soft tissue are the most common reasons for back pain. From occupational health perspective, back pain is among the most important reasons for the absence from work and occupational disability;[5] in fact, the longer the period of disease,[6] the less likely it is to improve and return to work.[1] Disability due to low back pain in addition to disturbance in doing daily and social activities has a very negative effect, from social and economic perspectives, on the patient and the community, which makes chronic low back pain highly important.[3] Today, chronic low back pain is one of the critical challenges in medicine. Patients with chronic low back pain are responsible for 80% of the costs paid for the treatment of low back pain that is also the reason for mobility restrictions in most people under 45 years.[7] In the developed countries, the overall cost paid for low back pain per year is 7.1 of total share of the gross national product. Clearly, most of the cost is related to counseling and treatment of patients with chronic low back pain rather than with intermittent and recursive low back pain.[8] The existence of various methods of treatment is because of no single cause of low back pain.[9] A variety of methods such as pharmacotherapy, acupuncture, infusions, and physical methods are the most common interventions for treatment of low back pain. However, the effects of these methods remain to be fully known.[6] An exercise program, developed based on the physical conditions of patients, can promote the quality of life in patients with chronic disease.[10,11,12,13,14]

 

 

Image of several women participating in Pilates exercises with the use of Pilates equipment. | El Paso, TX Chiropractor

 

Literature shows that the effect of exercise in controlling chronic low back pain is under study and there is strong evidence about the fact that movement therapy is effective to treat low back pain.[15] However, no specific recommendations exist about the type of exercise, and the effects of certain types of movement therapies have been determined in few studies.[9] Pilates training consists of the exercises that focus on improving flexibility and strength in all the body organs, without increasing the mass of muscles or destroying them. This training method consists of controlled movements that form a physical harmony between the body and brain, and can raise the ability of the body of people at any age.[16] In addition, people who do Pilates exercise would have better sleep and less fatigue, stress, and nervousness. This training method is based on standing, sitting, and lying positions, without intervals, jumping, and leaping; thus, it may reduce injuries resulting from the joint damage because the exercise movements in the ranges of motion in the above three positions are performed with deep breathing and muscle contraction.[17] McKenzie method, also called mechanical diagnosis and therapy and based on the patient’s active participation, is used and trusted by patients and the people who use this method worldwide. This method is based on physical therapy which has been frequently studied. The distinctive characteristic of this method is the principle of initial assessment.[18] This principle is a reliable and safe method to make a diagnosis that makes the correct treatment planning possible. In this way, the time and energy are not spent for costly tests, rather McKenzie therapists, using a valid indicator, quickly recognize that how much and how this method is fruitful for the patient. More appropriately, McKenzie method is a comprehensive approach based on the correct principles whose full understanding and following is very fruitful.[19] In the recent years, non-pharmacological approaches have attracted the attention of physicians and patients with low back pain.[20] Complementary therapies[21] and treatments with holistic nature (to increase physical and mental well-being) are appropriate to manage physical illness.[13] Complementary therapies can slow down disease progression and improve capacity and physical performance. The aim of the present study is to compare the effect of the Pilates and McKenzie training on pain and general health in men with chronic low back pain.

 

Image of several women engaging in McKenzie method exercises | El Paso, TX Chiropractor

 

Materials and Methods

 

This randomized clinical trial was conducted in Shahrekord, Iran. The total study population screened was 144. We decided to enroll at least 25% of the population, 36 individuals, using a systematic random sampling. First, the participants were numbered and a list was developed. The first case was selected using random number table and then one out of four patients was randomly enrolled. This process continued till a desired number of participants were enrolled. Then, the participants were randomly assigned to experimental (Pilates and McKenzie training) groups and control group. After explaining the research purposes to the participants, they were asked to complete the consent form for participation in the study. Furthermore, the patients were ensured that the research data are kept confidential and used only for research purposes.

 

Inclusion Criteria

 

The study population included men aged 40�55 years in Shahrekord, South-West Iran, with chronic back pain, that is, history of more than 3 months of low back pain and no specific disease or other surgery.

 

Exclusion Criteria

 

The exclusion criteria were low back arch or so-called army back, serious spinal pathology such as tumors, fractures, inflammatory diseases, previous spinal surgery, nerve root compromise in the lumbar region, spondylolysis or spondylolisthesis, spinal stenosis, neurological disorders, systemic diseases, cardiovascular diseases, and receiving other therapies simultaneously. The examiner who assessed the outcomes was blinded to group assignment. Twenty-four hours before the training, a pretest was administered to all three groups to determine pain and general health; and then, the training began after completion of the McGill Pain Questionnaire (MPQ) and the General Health Questionnaire-28 (GHQ-28). The MPQ can be used to evaluate a person experiencing significant pain. It can be used to monitor the pain over time and to determine the effectiveness of any intervention. Minimum pain score: 0 (would not be seen in a person with true pain), maximum pain score: 78, and the higher the pain score the more severe the pain. Investigators reported that the construct validity and the reliability of the MPQ were reported as a test-retest reliability of 0.70.[22] The GHQ is a self-administered screening questionnaire. Test-retest reliability has been reported to be high (0.78�0 0.9) and inter- and intra-rater reliability have both been shown to be excellent (Cronbach’s ? 0.9�0.95). High internal consistency has also been reported. The lower the score is, the better the general health is.[23]

 

The participants in the experimental groups started training program under supervision of a sports medicine specialist. The training program consisted of 18 sessions of supervised individual training for both groups, with the sessions held three times per week for 6 weeks. Each training session lasted for an hour and was performed at the Physiotherapy Clinic in the School of Rehabilitation of the Shahrekord University of Medical Sciences in 2014�2015. The first experimental group performed Pilates training for 6 weeks, three times a week about an hour per session. In each session, first, a 5-min warm-up and preparation procedures were run; and at the end, stretching and walking were done to return to the baseline condition. In the McKenzie group, six exercises were used: Four extension-type exercises and two flexion-types. The extension-type exercises were performed in prone and standing positions, and the flexion-type exercises in the supine and sitting positions. Each exercise was run ten times. In addition, the participants conducted twenty daily individual training sessions for an hour.[18] After training of both groups, the participants filled out the questionnaires and then the collected data were presented in both descriptive and inferential statistics. Furthermore, the control group without any training, at the end of a period when other groups have completed, filled the questionnaire. Descriptive statistics were used for central tendency indicators such as mean (� standard deviation) and relevant diagrams were used to describe the data. Inferential statistics, one-way ANOVA and post hoc Tukey’s test, were used to analyze the data. Data analysis was done by SPSS Statistics for Windows, Version 21.0 (IBM Corp. Released 2012. IBM Armonk, NY: IBM Corp). P < 0.05 was considered statistically significant.

 

Dr. Alex Jimenez’s Insight

Alongside the use of spinal adjustments and manual manipulations for low back pain, chiropractic care commonly utilizes therapeutic exercise methods to improve LBP symptoms, restoring the affected individual’s strength, flexibility and mobility as well as promoting a faster recovery. The Pilates and McKenzie method of training, as mentioned in the article, are compared to determine which therapeutic exercise is best for treating low back pain. As�a Level I Certified Pilates Instructor, Pilates training is implemented with chiropractic treatment to improve LBP more effectively. Patients participating in a therapeutic exercise method alongside a primary form of treatment for low back pain can experience additional benefits. McKenzie training can also be implemented with chiropractic treatment to further improve LBP symptoms. The purpose of this research study is to demonstrate evidence-based information on the benefits of Pilates and McKenzie methods for low back pain as well as to educate patients on which of the two therapeutic exercises should be considered to help treat their symptoms and achieve overall health and wellness.

 

Level I Certified Pilates Instructors at Our Location

 

Dr. Alex Jimenez D.C., C.C.S.T | Chief Clinical Director and Level I Certified Pilates Instructor

 

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Truide Torres | Director of Patient Relations Advocate Dept. and Level I Certified Pilates Instructor

Results

 

The results showed no significant difference between the case and control groups regarding the gender, marital status, job, educational level, and income. The results showed changes in pain index and general health in the participants before and after Pilates and McKenzie training in the two experimental and even control groups [Table 1].

 

Table 1 Mean Indexes of the Participants Before and After Intervention

 

A significant difference was seen in pain and general health between the control and the two experimental groups at the pre- and post-test, so that the exercise training (both Pilates and McKenzie) resulted in reduced pain and promoted general health; while in the control group, pain increased and general health declined.

 

Discussion

 

The results of this study indicate that back pain reduced and general health enhanced after exercise therapy with both Pilates and McKenzie training, but in the control group, pain was intensified. Petersen et al. study on 360 patients with chronic low back pain concluded that at the end of 8 weeks of McKenzie training and high-intensity endurance training and 2 months training at home, pain and disability decreased in McKenzie group at the end of 2 months, but at the end of 8 months, no differences were seen among the treatments.[24]

 

Image demonstrating a Pilates class with an Instructor | El Paso, TX Chiropractor

 

The results of another study show that McKenzie training is a beneficial method for reducing pain and increasing the movements of the spine in patients with chronic low back pain.[18] Pilates training can be an effective method for improving general health, athletic performance, proprioception, and reduction of pain in patients with chronic low back pain.[25] The improvements in strength seen in the participants in the present study were more likely to be due to decrease in pain inhibition than to neurological changes in muscle firing/recruitment patterns or to morphological (hypertrophic) changes in the muscle. In addition, neither of the treatments was superior over the other in view of reducing the intensity of pain. In the present study, 6 weeks of McKenzie training led to significant reduction in pain levels in men with chronic low back pain. The rehabilitation of patients with chronic low back pain is aimed to restore strength, endurance, and flexibility of soft tissues.

 

Udermann et al. showed that McKenzie training improved pain, disability, and psychosocial variables in patients with chronic low back pain, and back stretching training did not have any additional effect on pain, disability, and psychosocial variables.[26] The results of another study show that there is a reduction in pain and disability due to McKenzie method for at least 1 week in comparison with the passive treatment in patients with low back pain, but reduction in pain and disability due to McKenzie method in comparison with the active treatment methods is desirable within 12 weeks after treatment. Overall, McKenzie treatment is more effective than passive methods to treat low back pain.[27] One of the popular exercise therapies for patients with low back pain is McKenzie training program. McKenzie method leads to improvement of low back pain symptoms such as pain in the short-term. Moreover, McKenzie therapy is more effective in comparison with passive treatments. This training is designed to mobilize the spine and to strengthen the lumbar muscles. Previous studies have shown that weakness and atrophy in the body central muscles, particularly the transverse abdominal muscle in patients with low back pain.[28] The results of this research also showed that there was a significant difference in the general health indexes between Pilates and McKenzie groups. In the present study, 6 weeks of Pilates and McKenzie training led to a significant reduction in the level of general health (physical symptoms, anxiety, social dysfunction, and depression) in men with chronic low back pain and the general health in Pilates training group improved. The results of most studies show that exercise therapy reduces pain and improves general health in patients with chronic low back pain. Importantly, the agreement about the duration, type, and intensity of the training remains to be achieved and there is no definite training program that can have the best effect on patients with chronic low back pain. Therefore, more research is needed to determine the best duration and treatment method to reduce and improve general health in patients with low back pain. In the Al-Obaidi et al. study, pain, fear, and functional disability improved after 10 weeks of treatment in patients.[5]

 

Image of an Instructor demonstrating a patient the McKenzie method | El Paso, TX Chiropractor

 

Pilates Chiropractor vs. McKenzie Chiropractor: Which is Better? Body Image 6

 

Besides that McKenzie training increases the range of motion of lumbar flexion. Overall, neither of the two methods of treatment was superior over the other.[18]

 

Borges et al. concluded that after 6 weeks of treatment, the average index of pain in experimental group was lower than the control group. Furthermore, the general health of the experimental group exhibited greater improvement than the control group. The results of this research support recommending Pilates training to patients with chronic low back pain.[29] Caldwell et al. on the university students concluded that Pilates training and Tai chi guan improved mental parameters such as self-sufficiency, quality of sleep, and morality of students but had no effect on physical performance.[30] Garcia et al. study on 148 patients with nonspecific chronic low back pain concluded that treating patients with nonspecific chronic low back pain by McKenzie training and back school caused disability to improve after treatment, but quality of life, pain, and the range of motor flexibility did not change. McKenzie treatment is typically more effective on disability than back school program.[19]

 

The overall findings of this study are supported by the literature, demonstrating that a Pilates program may offer a low-cost, safe alternative to the treatment of low back pain in this specific group of patients. Similar effects have been found in patients with unspecific chronic low back pain.[31]

 

Our study had good levels of internal and external validity and thus can guide therapists and patients considering therapies of choice for back pain. The trial included a number of features to minimize bias such as prospectively registering and following a published protocol.

 

Study Limitation

 

Small sample size enrolled in this study limits the generalization of the study findings.

 

Conclusion

 

The results of this study showed that 6-week Pilates and McKenzie training reduced pain in patients with chronic low back pain, but there was no significant difference between the effect of two therapeutic methods on pain and both exercise protocols had the same effect. In addition, Pilates and McKenzie training improved general health; however, according to the mean general health changes after the exercise therapy, it can be argued that the Pilates training has a greater effect in improving general health.

 

Financial Support and Sponsorship

 

Nil.

 

Conflicts of Interest

 

There are no conflicts of interest.

 

In conclusion,�when comparing the effects of Pilates and McKenzie training on general health as well as on painful symptoms in men with chronic low back pain, the evidence-based research study determined that both the Pilates and the McKenzie method of training effectively reduced pain in patients with chronic LBP. There was no significant difference between the two therapeutic methods altogether, however, the mean results of the research study demonstrated that Pilates training was more effective towards improving general health in men with chronic low back pain than McKenzie training.� Information referenced from the National Center for Biotechnology Information (NCBI). The scope of our information is limited to chiropractic as well as to spinal injuries and conditions. To discuss the subject matter, please feel free to ask Dr. Jimenez or contact us at 915-850-0900 .

 

Curated by Dr. Alex Jimenez

 

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Additional Topics: Sciatica

 

Sciatica is referred to as a collection of symptoms rather than a single type of injury or condition. The symptoms are characterized as radiating pain, numbness and tingling sensations from the sciatic nerve in the lower back, down the buttocks and thighs and through one or both legs and into the feet. Sciatica is commonly the result of irritation, inflammation or compression of the largest nerve in the human body, generally due to a herniated disc or bone spur.

 

blog picture of cartoon paperboy big news

 

IMPORTANT TOPIC: EXTRA EXTRA: Treating Sciatica Pain

 

 

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References
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2. Hoy DG, Protani M, De R, Buchbinder R. The epidemiology of neck pain. Best Pract Res Clin Rheumatol. 2010;24:783�92. [PubMed]
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4. Sadock BJ, Sadock VA. Kaplan and Sadock’s Synopsis of Psychiatry: Behavioral Sciences/Clinical Psychiatry. New York: Lippincott Williams & Wilkins; 2011.
5. Al-Obaidi SM, Al-Sayegh NA, Ben Nakhi H, Al-Mandeel M. Evaluation of the McKenzie intervention for chronic low back pain by using selected physical and bio-behavioral outcome measures. PM R. 2011;3:637�46. [PubMed]
6. Dehkordi AH, Heydarnejad MS. Effect of booklet and combined method on parents’ awareness of children with beta-thalassemia major disorder. J Pak Med Assoc. 2008;58:485�7. [PubMed]
7. van der Wees PJ, Jamtvedt G, Rebbeck T, de Bie RA, Dekker J, Hendriks EJ. Multifaceted strategies may increase implementation of physiotherapy clinical guidelines: A systematic review. Aust J Physiother. 2008;54:233�41. [PubMed]
8. Maas ET, Juch JN, Groeneweg JG, Ostelo RW, Koes BW, Verhagen AP, et al. Cost-effectiveness of minimal interventional procedures for chronic mechanical low back pain: Design of four randomised controlled trials with an economic evaluation. BMC Musculoskelet Disord. 2012;13:260. [PMC free article] [PubMed]
9. Hernandez AM, Peterson AL. Handbook of Occupational Health and Wellness. Springer: 2012. Work-related musculoskeletal disorders and pain; pp. 63�85.
10. Hassanpour Dehkordi A, Khaledi Far A. Effect of exercise training on the quality of life and echocardiography parameter of systolic function in patients with chronic heart failure: A randomized trial. Asian J Sports Med. 2015;6:e22643. [PMC free article] [PubMed]
11. Hasanpour-Dehkordi A, Khaledi-Far A, Khaledi-Far B, Salehi-Tali S. The effect of family training and support on the quality of life and cost of hospital readmissions in congestive heart failure patients in Iran. Appl Nurs Res. 2016;31:165�9. [PubMed]
12. Hassanpour Dehkordi A. Influence of yoga and aerobics exercise on fatigue, pain and psychosocial status in patients with multiple sclerosis: A Randomized Trial. J Sports Med Phys Fitness. 2015 [Epub ahead of print] [PubMed]
13. Hassanpour-Dehkordi A, Jivad N. Comparison of regular aerobic and yoga on the quality of life in patients with multiple sclerosis. Med J Islam Repub Iran. 2014;28:141. [PMC free article] [PubMed]
14. Heydarnejad S, Dehkordi AH. The effect of an exercise program on the health-quality of life in older adults. A randomized controlled trial. Dan Med Bull. 2010;57:A4113. [PubMed]
15. van Middelkoop M, Rubinstein SM, Verhagen AP, Ostelo RW, Koes BW, van Tulder MW. Exercise therapy for chronic nonspecific low-back pain. Best Pract Res Clin Rheumatol. 2010;24:193�204. [PubMed]
16. Critchley DJ, Pierson Z, Battersby G. Effect of pilates mat exercises and conventional exercise programmes on transversus abdominis and obliquus internus abdominis activity: Pilot randomised trial. Man Ther. 2011;16:183�9. [PubMed]
17. Kloubec JA. Pilates for improvement of muscle endurance, flexibility, balance, and posture. J Strength Cond Res. 2010;24:661�7. [PubMed]
18. Hosseinifar M, Akbari A, Shahrakinasab A. The effects of McKenzie and lumbar stabilization exercises on the improvement of function and pain in patients with chronic low back pain: A randomized controlled trial. J Shahrekord Univ Med Sci. 2009;11:1�9.
19. Garcia AN, Costa Lda C, da Silva TM, Gondo FL, Cyrillo FN, Costa RA, et al. Effectiveness of back school versus McKenzie exercises in patients with chronic nonspecific low back pain: A randomized controlled trial. Phys Ther. 2013;93:729�47. [PubMed]
20. Hassanpour-Dehkordi A, Safavi P, Parvin N. Effect of methadone maintenance treatment of opioid dependent fathers on mental health and perceived family functioning of their children. Heroin Addict Relat Clin. 2016;18(3):9�14.
21. Shahbazi K, Solati K, Hasanpour-Dehkordi A. Comparison of hypnotherapy and standard medical treatment alone on quality of life in patients with irritable bowel syndrome: A Randomized Control Trial. J Clin Diagn Res. 2016;10:OC01�4. [PMC free article] [PubMed]
22. Ngamkham S, Vincent C, Finnegan L, Holden JE, Wang ZJ, Wilkie DJ. The McGill Pain Questionnaire as a multidimensional measure in people with cancer: An integrative review. Pain Manag Nurs. 2012;13:27�51. [PMC free article] [PubMed]
23. Sterling M. General health questionnaire-28 (GHQ-28) J Physiother. 2011;57:259. [PubMed]
24. Petersen T, Kryger P, Ekdahl C, Olsen S, Jacobsen S. The effect of McKenzie therapy as compared with that of intensive strengthening training for the treatment of patients with subacute or chronic low back pain: A randomized controlled trial. Spine (Phila Pa 1976) 2002;27:1702�9. [PubMed]
25. Gladwell V, Head S, Haggar M, Beneke R. Does a program of pilates improve chronic non-specific low back pain? J Sport Rehabil. 2006;15:338�50.
26. Udermann BE, Mayer JM, Donelson RG, Graves JE, Murray SR. Combining lumbar extension training with McKenzie therapy: Effects on pain, disability, and psychosocial functioning in chronic low back pain patients. Gundersen Lutheran Med J. 2004;3:7�12.
27. Machado LA, Maher CG, Herbert RD, Clare H, McAuley JH. The effectiveness of the McKenzie method in addition to first-line care for acute low back pain: A randomized controlled trial. BMC Med. 2010;8:10. [PMC free article] [PubMed]
28. Kilpikoski S. The McKenzie Method in Assessing, Classifying and Treating Non-Specific Low Back Pain in Adults with Special Reference to the Centralization Phenomenon. Jyv�skyl� University of Jyv�skyl� 2010
29. Borges J, Baptista AF, Santana N, Souza I, Kruschewsky RA, Galv�o-Castro B, et al. Pilates exercises improve low back pain and quality of life in patients with HTLV-1 virus: A randomized crossover clinical trial. J Bodyw Mov Ther. 2014;18:68�74. [PubMed]
30. Caldwell K, Harrison M, Adams M, Triplett NT. Effect of pilates and taiji quan training on self-efficacy, sleep quality, mood, and physical performance of college students. J Bodyw Mov Ther. 2009;13:155�63. [PubMed]
31. Altan L, Korkmaz N, Bingol U, Gunay B. Effect of pilates training on people with fibromyalgia syndrome: A pilot study. Arch Phys Med Rehabil. 2009;90:1983�8. [PubMed]
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Chiropractic for Low Back Pain and Sciatica

Chiropractic for Low Back Pain and Sciatica

Chiropractic Management of Low Back Pain and Low Back-Related Leg Complaints: A Literature Synthesis

 

Chiropractic care is a well-known complementary and alternative treatment option frequently used to diagnose, treat and prevent injuries and conditions of the musculoskeletal and nervous systems. Spinal health issues are among some of the most common reasons people seek chiropractic care, especially for low back pain and sciatica complaints. While there are many different types of treatments available to help improve low back pain and sciatica symptoms, many individuals will often prefer natural treatment options over the use of drugs/medications or surgical interventions. The following research study demonstrates a list of evidence-based chiropractic treatment methods and their effects towards improving a variety of spinal health issues.

 

Abstract

 

  • Objectives: The purpose of this project was to review the literature for the use of spinal manipulation for low back pain (LBP).
  • Methods: Asearch strategymodified fromthe Cochrane Collaboration reviewforLBP was conducted through the following databases: PubMed, Mantis, and the Cochrane Database. Invitations to submit relevant articles were extended to the profession via widely distributed professional news and association media. The Scientific Commission of the Council on Chiropractic Guidelines and Practice Parameters (CCGPP) was charged with developing literature syntheses, organized by anatomical region, to evaluate and report on the evidence base for chiropractic care. This article is the outcome of this charge. As part of the CCGPP process, preliminary drafts of these articles were posted on the CCGPP Web site www.ccgpp.org (2006-8) to allow for an open process and the broadest possible mechanism for stakeholder input.
  • Results: A total of 887 source documents were obtained. Search results were sorted into related topic groups as follows: randomized controlled trials (RCTs) of LBP and manipulation; randomized trials of other interventions for LBP; guidelines; systematic reviews and meta-analyses; basic science; diagnostic-related articles, methodology; cognitive therapy and psychosocial issues; cohort and outcome studies; and others. Each group was subdivided by topic so that team members received approximately equal numbers of articles from each group, chosen randomly for distribution. The team elected to limit consideration in this first iteration to guidelines, systematic reviews, meta-analyses, RCTs, and coh ort studies. This yielded a total of 12 guidelines, 64 RCTs, 13 systematic reviews/meta-analyses, and 11 cohort studies.
  • Conclusions: As much or more evidence exists for the use of spinal manipulation to reduce symptoms and improve function in patients with chronic LBP as for use in acute and subacute LBP. Use of exercise in conjunction with manipulation is likely to speed and improve outcomes as well as minimize episodic recurrence. There was less evidence for the use of manipulation for patients with LBP and radiating leg pain, sciatica, or radiculopathy. (J Manipulative Physiol Ther 2008;31:659-674)
  • Key Indexing Terms: Low Back Pain; Manipulation; Chiropractic; Spine; Sciatica; Radiculopathy; Review, Systematic

 

The Council on Chiropractic Guidelines and Practice Parameters (CCGPP) was formed in 1995 by the Congress of Chiropractic State Associations with assistance from the American Chiropractic Association, Association of Chiropractic Colleges, Council on Chiropractic Education, Federation of Chiropractic Licensing�Boards, Foundation for the Advancement of Chiropractic Sciences, Foundation for Chiropractic Education and Research, International Chiropractors Association, National Association of Chiropractic Attorneys, and the National Institute for Chiropractic Research. The charge to the CCGPP was to create a chiropractic �best practices� document. The Council on Chiropractic Guidelines and Practice Parameters was delegated to examine all existing guidelines, parameters, protocols, and best practices in the United States and other nations in the construction of this document.

 

Toward that end, the Scientific Commission of CCGPP was charged with developing literature syntheses, organized by region (neck, low back, thoracic, upper and lower extremity, soft tissue) and the nonregional categories of nonmusculoskeletal, prevention/health promotion, special populations, subluxation, and diagnostic imaging.

 

The purpose of this work is to provide a balanced interpretation of the literature to identify safe and effective treatment options in the care of patients with low back pain (LBP) and related disorders. This evidence summary is intended to serve as a resource for practitioners to assist them in consideration of various care options for such patients. It is neither a replacement for clinical judgment nor a prescriptive standard of care for individual patients.

 

Image of a chiropractor performing spinal adjustments and manual manipulations for low back pain and sciatica.

 

Methods

 

Process development was guided by experience of commission members with the RAND consensus process, Cochrane collaboration, Agency for Health Care and Policy Research, and published recommendations modified to the needs of the council.

 

Identification and Retrieval

 

The domain for this report is that of LBP and low backrelated leg symptoms. Using surveys of the profession and publications on practice audits, the team selected the topics for review by this iteration.

 

Topics were selected based on the most common disorders seen and most common classifications of treatments used by chiropractors based on the literature. Material for review was obtained through formal hand searches of published literature and of electronic databases, with assistance from a professional chiropractic college librarian. A search strategy was developed, based upon the CochraneWorking Group for Low Back Pain. Randomized controlled trials (RCTs), systematic reviews/meta-analyses, and guidelines published through 2006 were included; all other types of studies were included through 2004. Invitations to submit relevant articles were extended to the profession via widely distributed professional news and association media. Searches focused on guidelines, meta-analyses, systematic reviews, randomized clinical trials, cohort studies, and case series.

 

Evaluation

 

Standardized and validated instruments used by the Scottish Intercollegiate Guidelines Network were used to evaluate RCTs and systematic reviews. For guidelines, the Appraisal of Guidelines for Research and Evaluation instrument was used. A standardized method for grading the strength of the evidence was used, as summarized in Figure 1. Each team’s multidisciplinary panel conducted the review and evaluation of the evidence.

 

Figure 1 Summary of Grading of Strength of Evidence

 

Search results were sorted into related topic groups as follows: RCTs of LBP and manipulation; randomized trials of other interventions for LBP; guidelines; systematic reviews and meta-analyses; basic science; diagnosticrelated articles; methodology; cognitive therapy and psychosocial issues; cohort and outcome studies; and others. Each group was subdivided by topic so that team members received approximately equal numbers of articles from each group, chosen randomly for distribution. On the basis of the CCGPP formation of an iterative process and the volume of work available, the team elected to limit consideration in this first iteration to guidelines, systematic reviews, meta-analyses, RCTs, and cohort studies.

 

Dr. Alex Jimenez’s Insight

How does chiropractic care benefit people with low back pain and sciatica?�As a chiropractor experienced in the management of a variety of spine health issues, including low back pain and sciatica, spinal adjustments and manual manipulations, as well as other non-invasive treatment methods, can be safely and effectively implemented towards the improvement of back pain symptoms. The purpose of the following research study is to demonstrate the evidence-based effects of chiropractic in the treatment of injuries and conditions of the musculoskeletal and nervous systems. The information in this article can educate patients on how alternative treatment options can help improve their low back pain and sciatica. As a chiropractor, patients may also be referred to other healthcare professionals, such as physical therapists, functional medicine practitioners and medical doctors, to help them further manage their low back pain and sciatica symptoms. Chiropractic care can be used to avoid surgical interventions for spine health issues.

 

Results and Discussion

 

A total of 887 source documents were initially obtained. This included a total of 12 guidelines, 64 RCTs, 20 systematic reviews/meta-analyses, and 12 cohort studies. Table 1 provides an overall summary of the number of studies evaluated.

 

Table 1 Number of Sources Rated by the Interdisciplinary Team of Reviewers and Used in Formulating Conclusions

 

Assurance and Advice

 

The search strategy used by the team was that developed by van Tulder et al, and the team identified 11 trials. Good evidence indicates that patients with acute LBP on bed rest have more pain and less functional recovery than those who stay active. There is no difference in pain and functional status between bed rest and exercises. For sciatica patients, fair evidence shows no real difference in pain and functional status between bed rest and staying active. There is fair evidence of no difference in pain intensity between bed rest and physiotherapy but small improvements in functional status. Finally, there is little difference in pain intensity or functional status between shorter-term or longer-term bed rest.

 

A Cochrane review by Hagen et al demonstrated small advantages in short-term and long-term for staying active over bed rest, as did a high-quality review by the Danish Society of Chiropractic and Clinical Biomechanics, including 4 systematic reviews, 4 additional RCTS, and 6 guidelines, on acute LBP and sciatica. The Cochrane review by Hilde et al included 4 trials and concluded a small beneficial effect for staying active for acute, uncomplicated LBP, but no benefit for sciatica. Eight studies on staying active and 10 on bed rest were included in an analysis by the group of Waddell. Several therapies were coupled with advice to stay active and include analgesic medication, physical therapy, back school, and behavioral counseling. Bed rest for acute LBP was similar to no treatment and placebo and less effective than alternative treatment. Outcomes considered across the studies were rate of recovery, pain, activity levels, and work time loss. Staying active was found to have a favorable effect.

 

Review of 4 studies not covered elsewhere assessed the use of brochures/booklets. The trend was for no differences in outcome for pamphlets. One exception was noted�that those who received manipulation had less bothersome symptoms at 4 weeks and significantly less disability at 3 months for those who received a booklet encouraging staying active.

 

In summary, assuring patients that they are likely to do well and advising them to stay active and avoid bed rest is a best practice for management of acute LBP. Bed rest for short intervals may be beneficial for patients with radiating leg pain who are intolerant of weight bearing.

 

Adjustment/Manipulation/Mobilization Vs Multiple Modalities

 

This review considered literature on high-velocity, lowamplitude (HVLA) procedures, often termed adjustment or manipulation, and mobilization. The HVLA procedures use thrusting maneuvers applied quickly; mobilization is applied cyclically. The HVLA procedure and mobilization may be mechanically assisted; mechanical impulse devices are considered HVLA, and flexion-distraction methods and continuous passive motion methods are within mobilization.

 

Image of a chiropractor performing spinal adjustments and manual manipulations for low back pain and sciatica.

 

The team recommends adopting the findings of the systematic review by Bronfort et al, with a quality score (QS) of 88, covering literature up to 2002. In 2006, the Cochrane collaboration reissued an earlier (2004) review of spinal manipulative therapy (SMT) for back pain performed by Assendelft et al. This reported on 39 studies up to 1999, several overlapping with those reported by Bronfort et al using different criteria and a novel analysis. They report no difference in outcome from treatment with manipulation vs alternatives. As several additional RCTs had appeared in the interim, the rationale for reissuing the older review without acknowledging new studies was unclear.

 

Acute LBP. There was fair evidence that HVLA has better short-term efficacy than mobilization or diathermy and limited evidence of better short-term efficacy than diathermy, exercise, and ergonomic modifications.

 

Chronic LBP. The HVLA procedure combined with strengthening exercise was as effective for pain relief as nonsteroidal antiinflammatory dugs with exercise. Fair evidence indicated that manipulation is better than physical therapy and home exercise for reducing disability. Fair evidence shows that manipulation improves outcomes more than general medical care or placebo in the short-term and to physical therapy in the long-term. The HVLA procedure had better outcomes than home exercise, transcutaneous�electrical nerve stimulation, traction, exercise, placebo and sham manipulation, or chemonucleolysis for disk herniation.

 

Mixed (Acute and Chronic) LBP. Hurwitz found that HVLA was the same as medical care for pain and disability; adding physical therapy to manipulation did not improve outcomes. Hsieh found no significant value for HVLA over back school or myofascial therapy. A short-term value of manipulation over a pamphlet and no difference between manipulation and McKenzie technique were reported by Cherkin et al. Meade contrasted manipulation and hospital care, finding greater benefit for manipulation over both short-term and long-term. Doran and Newell found that SMT resulted in greater improvement than physical therapy or corsets.

 

Acute LBP

 

Sick List Comparisons. Seferlis found that sick patients listed were significantly improved symptomatically after 1 month regardless of the intervention, including manipulation. Patients were more satisfied and felt that they were provided better explanations about their pain from practitioners who used manual therapy (QS, 62.5). Wand et al examined the effects of sick-listing oneself and noted that a group receiving assessment, advice, and treatment improved better than did a group getting assessment, advice, and who were put on a wait list for a 6-week period. Improvements were observed in disability, general health, quality of life, and mood, though pain and disability were not different at longterm follow-up (QS, 68.75).

 

Physiologic Therapeutic Modality and Exercise. Hurley and colleagues tested the effects of manipulation combined with interferential therapy compared to either modality alone. Their results showed all 3 groups improved function to the same degree, both at 6-month and at 12-month follow-up (QS, 81.25). Using a single-blinded experimental design to compare manipulation to massage and low-level electrostimulation, Godfrey et al found no differences between groups at the 2 to 3-week observation time frame (QS, 19). In the study by Rasmussen, results showed that 94% of the patients treated with manipulation were symptom-free within 14 days, compared to 25% in the group that received short-wave diathermy. Sample size was small, however, and as a result, the study was underpowered (QS, 18). The Danish systematic review examined 12 international sets of guidelines, 12 systematic reviews, and 10 randomized clinical trials on exercise. They found no specific exercises, regardless of type, that were useful for the treatment of acute LBP with the exception of McKenzie maneuvers.

 

Sham and Alternate Manual Method Comparisons. The study of Hadler balanced for effects of provider attention and physical contact with a first effort at a manipulation sham procedure. Patients in the group that entered the trial with greater prolonged illness at the outset were reported to have benefited from the manipulation. Similarly, they improved faster and to a greater degree (QS, 62.5). Hadler demonstrated that there was a benefit for a single session of manipulation compared to a session of mobilization (QS, 69). Erhard reported that the rate of positive response to manual treatment with a hand-heel rocking motion was greater than with extension exercises (QS, 25). Von Buerger examined the use of manipulation for acute LBP, comparing rotational manipulation to soft tissue massage. He found that the manipulation group responded better than the soft tissue group, although the effects occurred mainly in the short-term. The results were also hampered by the nature of the forced multiple choice selections on the data forms (QS, 31). Gemmell compared 2 forms of manipulation for LBP of less than 6 weeks of duration as follows: Meric adjusting (a form of HVLA) and Activator technique (a form of mechanically assisted HVLA). No difference was observed, and both helped to reduce pain intensity (QS, 37.5). MacDonald reported a short-term benefit in disability measures within the first 1 to 2 weeks of starting therapy for the manipulation group that disappeared by 4 weeks in a control group (QS, 38). The work of Hoehler, although containing mixed data for patients with acute and chronic LBP, is included here because a larger proportion of patients with acute LBP were involved in the study. Manipulation patients reported immediate relief more often, but there were no differences between groups at discharge (QS, 25).

 

Medication. Coyer showed that 50% of the manipulation group was symptom-free within 1 week and 87% were discharged symptom-free in 3 weeks, compared to 27% and 60%, respectively, of the control group (bed rest and analgesics) (QS, 37.5). Doran and Newell compared manipulation, physiotherapy, corset, or analgesic medication, using outcomes that examined pain and mobility. There were no differences between groups over time (QS, 25). Waterworth compared manipulation to conservative physiotherapy and 500 mg of diflunisal twice per day for 10 days. Manipulation showed no benefit for the rate of recovery (QS, 62.5). Blomberg compared manipulation to steroid injections and to a control group receiving conventional activating therapy. After 4 months, the manipulation group had less restricted motion in extension, less restriction in side-bending to both sides, less local pain on extension and right sidebending, less radiating pain, and less pain when performing a straight leg raise (QS, 56.25). Bronfort found no outcome differences between chiropractic care compared to medical care at 1 month of treatment, but there were noticeable improvements in the chiropractic group at both 3 and 6-month follow-up (QS, 31).

 

Subacute Back Pain

 

Staying Active. Grunnesjo compared combined effects of manual therapy with advice to stay active to advice alone in patients with acute and subacute LBP. The addition of�manual therapy appeared to reduce pain and disability more effectively than the �stay active� concept alone (QS, 68.75).

 

Physiologic Therapeutic Modality and Exercise. Pope demonstrated that manipulation offered better pain improvement than transcutaneous electrical nerve stimulation (QS 38). Sims-Williams compared manipulation to �physiotherapy.� Results demonstrated a short-term benefit for manipulation on pain and ability to do light work. Differences between groups waned at 3 and 12-month follow-ups (QS, 43.75, 35). Skargren et al compared chiropractic to physiotherapy for patients with LBP who had no treatment for the prior month. No differences in health improvements, costs, or recurrence rates were noted between the 2 groups. However, based on Oswestry scores, chiropractic performed better for patients who had pain for less than 1 week, whereas the physiotherapy seemed to be better for those who had pain for more than 4 weeks (QS, 50).

 

The Danish systematic review examined 12 international sets of guidelines, 12 systematic reviews, and 10 randomized clinical trials on exercise. Results suggested that exercise, in general, benefits patients with subacute back pain. Use of a basic program that can be readily modified to meet individual patient needs is recommended. Issues of strength, endurance, stabilization, and coordination without excessive loading can all be addressed without the use of high-tech equipment. Intensive training consisting of greater than 30 and less than 100 hours of training are most effective.

 

Sham and Alternate Manual Method Comparisons. Hoiriis compared efficacy of chiropractic manipulation to placebo/ sham for subacute LBP. All groups improved on measures of pain, disability, depression, and Global Impression of Severity. Chiropractic manipulation scored better than placebo in reducing pain and Global Impression of Severity scores (QS, 75). Andersson and colleagues compared osteopathic manipulation to standard care to patients with subacute LBP, finding that both groups improved for a 12-week period at about the same rate (QS, 50).

 

Medication Comparisons. In a separate treatment arm of the study of Hoiriis, the relative efficacy of chiropractic manipulation to muscle relaxants for subacute LBP was studied. In all groups, pain, disability, depression, and Global Impression of Severity decreased. Chiropractic manipulation was more effective than muscle relaxants in reducing Global Impression of Severity scores (QS, 75).

 

Chronic LBP

 

Staying Active Comparisons. Aure compared manual therapy to exercise in patients with chronic LBP who were sick listed. Although both groups showed improvements in pain intensity, functional disability, general health, and return to work, the manual therapy group showed significantly greater improvements than did the exercise group for all outcomes. Results were consistent for both the short-term and the longterm (QS, 81.25).

 

Physician Consult/Medical Care/Education. Niemisto compared combined manipulation, stabilization exercise, and physician consultation to consultation alone. The combined intervention was more effective in reducing pain intensity and disability (QS, 81.25). Koes compared general practitioner treatment to manipulation, physiotherapy, and a placebo (detuned ultrasound). Assessments were made at 3, 6, and 12 weeks. The manipulation group had a quicker and larger improvement in physical function compared to the other therapies. Changes in spinal mobility in the groups were small and inconsistent (QS, 68). In a follow-up report, Koes found during subgroup analysis that improvement in pain was greater for manipulation than for other treatments at 12 months when considering patients with chronic conditions, as well as those who were younger than 40 years (QS, 43). Another study by Koes showed that many patients in the nonmanipulation treatment arms had received additional care during follow-up. Yet, improvement in the main complaints and in physical functioning remained better in the manipulation group (QS, 50). Meade observed that chiropractic treatment was more effective than hospital outpatient care, as assessed using the Oswestry Scale (QS, 31). An RCT conducted in Egypt by Rupert compared chiropractic manipulation, after medical and chiropractic evaluation. Pain, forward flexion, active, and passive leg raise all improved to a greater degree in the chiropractic group; however, the description of alternate treatments and outcomes was ambiguous (QS, 50).

 

Triano compared manual therapy to educational programs for chronic LBP. There was greater improvement in pain, function, and activity tolerance in the manipulation group, which continued beyond the 2-week treatment period (QS, 31).

 

Physiologic Therapeutic Modality. A negative trial for manipulation was reported by Gibson (QS, 38). Detuned diathermy was reported to achieve better results over manipulation, although there were baseline differences between groups. Koes studied the effectiveness of manipulation, physiotherapy, treatment by a general practitioner, and a placebo of detuned ultrasound. Assessments were made at 3, 6, and 12 weeks. The manipulation group showed a quicker and better improvement in physical function capacity compared to the other therapies. Flexibility differences between groups were not significant (QS, 68). In a follow-up report, Koes found that a subgroup analysis demonstrated that improvement in pain was greater for those treated with manipulation, both for younger (b40) patients and those with chronic conditions at 12-month follow-up (QS, 43). Despite many patients in the nonmanipulation groups received additional care during follow-up, improvements remained better in the manipulation group than in the physical therapy group (QS, 50). In a separate report by the same group, there were improvements in both the physiotherapy and manual therapy groups with regard to severity of complaints and global perceived effect compared to general practitioner care;�however, the differences between the 2 groups was not significant (QS, 50). Mathews et al found that manipulation hastened recovery from LBP more than the control did.

 

Exercise Modality. Hemilla observed that SMT led to better long-term and short-term disability reduction compared to physical therapy or home exercise (QS, 63). A second article by the same group found that neither bone-setting nor exercise differed significantly from physical therapy for symptom control, though bone-setting was associated with improved lateral and forward-bending of the spine more than exercise (QS, 75). Coxhea reported that HVLA provided better outcomes when compared to exercise, corsets, traction, or no exercise when studied in the short-term (QS, 25). Conversely, Herzog found no differences between manipulation, exercise, and back education in reducing either pain or disability (QS, 6). Aure compared manual therapy to exercise in patients with chronic LBP who were also sick listed. Although both groups showed improvements in pain intensity, functional disability, and general health and returned to work, the manual therapy group showed significantly greater improvements than did the exercise group for all outcomes. This result persisted for both the short-term and the long-term (QS, 81.25). In the article by Niemisto and colleagues, the relative efficacy of combined manipulation, exercise (stabilizing forms), and physician consultation compared to consultation alone was investigated. The combined intervention was more effective in reducing pain intensity and disability (QS, 81.25). The United Kingdom Beam study found that manipulation followed by exercise achieved a moderate benefit at 3 months and a small benefit at 12 months. Likewise, manipulation achieved a small to moderate benefit at 3 months and a small benefit at 12 months. Exercise alone had a small benefit at 3 months but no benefit at 12 months. Lewis et al found improvement occurred when patients were treated by combined manipulation and spinal stabilization exercises vs use of a 10-station exercise class.

 

The Danish systematic review examined 12 international sets of guidelines, 12 systematic reviews, and 10 randomized clinical trials on exercise. Results suggested that exercise, in general, benefits patients with chronic LBP. No clear superior method is known. Use of a basic program that can be readily modified to meet individual patient needs is recommended. Issues of strength, endurance, stabilization, and coordination without excessive loading can all be addressed without the use of high-tech equipment. Intensive training consisting of greater than 30 and less than 100 hours of training are most effective. Patients with severe chronic LBP, including those off work, are treated more effectively with a multidisciplinary rehabilitation program. For post surgical rehabilitation, patients starting 4 to 6 weeks after disk surgery under intensive training receive greater benefit than with light exercise programs.

 

Sham and Alternate Manual Methods. Triano found that SMT produced significantly better results for pain and disability relief for the short-term, than did sham manipulation (QS, 31). Cote found no difference over time or for comparisons within or between the manipulation and mobilization groups (QS, 37.5). The authors posed that failure to observe differences may have been due to low responsiveness to change in the instruments used for algometry, coupled with a small sample size. Hsieh found no significant value for HVLA over back school or myofascial therapy (QS, 63). In the study by Licciardone, a comparison was made between osteopathic manipulation (which includes mobilization and soft tissue procedures as well as HVLA), sham manipulation, and a no-intervention control for patients with chronic LBP. All groups showed improvement. Sham and osteopathic manipulation were associated with greater improvements than seen in the no-manipulation group, but no difference was observed between the sham and manipulation groups (QS, 62.5). Both subjective and objective measures showed greater improvements in the manipulation group compared to a sham control, in a report by Waagen (QS, 44). In the work of Kinalski, manual therapy reduced the time of treatment of patients with LBP and concomitant intervertebral disk lesions. When disk lesions were not advanced, a decreased muscular hypertonia and increased mobility was noted. This article, however, was limited by a poor description of patients and methods (QS, 0).

 

Harrison et al reported a nonrandomized cohort controlled trial of treatment of chronic LBP consisting of 3-point bending traction designed to increase curvature of the lumbar spine. The experimental group received HVLA for pain control during the first 3 weeks (9 treatments). The control group received no treatment. Follow-up at a mean of 11 weeks showed no change in pain or curvature status for controls but a significant increase in curvature and reduction of pain in the experimental group. Average number of treatments to achieve this result was 36. Long-term followup at 17 months showed retention of benefits. No report of relationship between clinical changes and structural change was given.

 

Haas and colleagues examined the dose-response patterns of manipulation for chronic LBP. Patients were randomly allocated to groups receiving 1, 2, 3, or 4 visits per week for 3 weeks, with outcomes recorded for pain intensity and functional disability. A positive and clinically important effect of the number of chiropractic treatments on pain intensity and disability at 4 weeks was associated with the groups receiving the higher rates of care (QS, 62.5). Descarreaux et al extended this work, treating 2 small groups for 4 weeks (3 times per week) after 2 baseline evaluations separated by 4 weeks. One group was then treated every 3 weeks; the other did not. Although both groups had lower Oswestry scores at 12 weeks, at 10 months, the improvement only persisted for the extended SMT group.

 

Medication. Burton and colleagues demonstrated that HVLA led to greater short-term improvements in pain and disability than did chemonucleolysis for managing disk�herniation (QS, 38). Bronfort studied SMT combined with exercise vs a combination of nonsteroidal antiinflammatory drugs and exercise. Similar results were obtained for both groups (QS, 81). Forceful manipulation coupled with sclerosant therapy (injection of a proliferant solution composed of dextrose-glycerine-phenol) was compared to lower force manipulation combined with saline injections, in a study by Ongley. The group receiving forceful manipulation with sclerosant fared better than the alternate group, but effects cannot be separated between the manual procedure and the sclerosant (QS, 87.5). Giles and Muller compared HVLA procedures to medication and acupuncture. Manipulation showed greater improvement in frequency of back pain, pain scores, Oswestry, and SF-36 compared to the other 2 interventions. Improvements lasted for 1 year. Weaknesses of the study were use of a compliers-only analysis as intention to treat for the Oswestry, and Visual Analogue Scale (VAS) was not significant.

 

Sciatica/Radicular/Radiating Leg Pain

 

Staying Active/Bed Rest. Postacchini studied a mixed group of patients with LBP, with and without radiating leg pain. Patients could be classified as acute or chronic and were evaluated at 3 weeks, 2 months, and 6 months postonset. Treatments included manipulation, drug therapy, physiotherapy, placebo, and bed rest. Acute back pain without radiation and chronic back pain responded well to manipulation; however, in none of the other groups did manipulation fare as well as other interventions (QS, 6).

 

Physician Consult/Medical Care/Education. Arkuszewski looked at patients with lumbosacral pain or sciatica. One group received drugs, physiotherapy, and manual examination, whereas the second added manipulation. The group receiving manipulation had a shorter treatment time and a more marked improvement. At 6-month follow-up, the manipulation group showed better neuromotor system function and a better ability to continue employment. Disability was lower in the manipulation group (QS, 18.75).

 

Physiologic Therapeutic Modality. Physiotherapy combined with manual manipulation and medication was examined by Arkuszewski, in contrast to the same scheme with manipulation added, as noted above. Outcomes from manipulation were better for neurologic and motor function as well as disability (QS, 18.75). Postacchini looked at patients with acute or chronic symptoms evaluated at 3 weeks, 2 months, and 6 months postonset. Manipulation was not as effective for managing the patients with radiating leg pain as the other treatment arms (QS, 6). Mathews and colleagues examined multiple treatments including manipulation, traction, sclerosant use, and epidural injections for back pain with sciatica. For patients with LBP and restricted straight leg raise test, manipulation conferred highly significant relief, more so than alternate interventions (QS, 19). Coxhead et al included among their subjects patients who had radiating pain at least to the buttocks. Interventions included traction, manipulation, exercise, and corset, using a factorial design. After 4 weeks of care, manipulation showed a significant degree of benefit on one of the scales used to assess progress. There were no real differences between groups at 4 months and 16 months posttherapy, however (QS, 25).

 

Exercise Modality. In the case of LBP after laminectomy, Timm reported that exercises conferred benefit both for pain relief and cost-effectiveness (QS, 25). Manipulation had only a small influence on improvement of either symptoms or function (QS, 25). In the study by Coxhead et al, radiating pain to at least the buttocks was better after 4 weeks of care for manipulation, in contrast to other treatments that disappeared 4 months and 16 months posttherapy (QS, 25).

 

Sham and Alternate Manual Method. Siehl looked at the use of manipulation under general anesthesia for patients with LBP and unilateral or bilateral radiating leg pain. Only temporary clinical improvement was noted when traditional electromyographic evidence of nerve root involvement was present. With negative electromyography, manipulation was reported to provide lasting improvement (QS, 31.25) Santilli and colleagues compared HVLA to soft tissue pressing without any sudden thrust in patients with moderate acute back and leg pain. The HVLA procedures were significantly more effective in reducing pain, reaching a pain-free status, and the total number of days with pain. Clinically significant differences were noted. The total number of treatment sessions was capped at 20 on a dosage of 5 times per week with care depending on pain relief. Follow-up showed relief persisting through 6 months.

 

Medication. Mixed acute and chronic back pain with radiation treated in a study using multiple treatment arms were evaluated at 3 weeks, 2 months, and 6 months postonset by the group of Postacchini. Medication management fared better than did manipulation when radiating leg pain was present (QS, 6). Conversely, for the work of Mathews and colleagues, the group of patients with LBP and limited straight leg raise test responded more to manipulation than to epidural steroid or sclerosants (QS, 19).

 

Disk Herniation

 

Nwuga studied 51 subjects who were having a diagnosis of prolapsed intervertebral disk and who had been referred for physical therapy. Manipulation was reported to be superior to conventional therapy (QS, 12.5). Zylbergold found that there were no statistical differences between 3 treatments�lumbar flexion exercises, home care, and manipulation. Short-term follow-up and a small sample size were posed by the author as a basis for failing to reject the null hypothesis (QS, 38).

 

Exercise

 

Exercise is one of the most well-studied forms of treatment of low back disorders. There are many different approaches to�exercise. For this report, it is important only to differentiate multidisciplinary rehabilitation. These programs are designed for patients with especially chronic condition with significant psychosocial problems. They involve trunk exercise, functional task training including work simulation/vocational training, and psychological counseling.

 

Image of a healthcare professional helping a patient perform exercises for low back pain and sciatica.

 

In a recent Cochrane review on exercise for the treatment of nonspecific LBP (QS, 82), effectiveness of exercise therapy in patients classified as acute, subacute, and chronic was compared to no treatment and alternate treatments. Outcomes included the assessment of pain, function, return to work, absenteeism, and/or global improvements. In the review, 61 trials met the inclusion criteria, most of which dealt with chronic (n = 43), whereas smaller numbers addressed acute (n = 11) and subacute (n = 6) pain. The general conclusions were as follows:

 

  • exercise is not effective as a treatment of acute LBP,
  • evidence that exercise was effective in chronic populations relative to comparisons made at follow-up periods,
  • mean improvements of 13.3 points for pain and 6.9 points for function were observed, and
  • there is some evidence that graded-activity exercise is effective for subacute LBP but only in the occupational setting

 

The review examined population and intervention characteristics, as well as outcomes to reach its conclusions. Extracting data on return to work, absenteeism, and global improvement proved so difficult that only pain and function could be quantitatively described.

 

Eight studies scored positively on key validity criteria. With regard to clinical relevance, many of the trials presented inadequate information, with 90% reporting the study population but only 54% adequately describing the exercise intervention. Relevant outcomes were reported in 70% of the trials.

 

Exercise for Acute LBP. Of the 11 trials (total n = 1192), 10 had nonexercise comparison groups. The trials presented conflicting evidence. Eight low-quality trials showed no differences between exercise and usual care or no treatment. Pooled data showed that there was no difference in shortterm pain relief between exercise and no treatment, no difference in early follow-up for pain when compared to other interventions, and no positive effect of exercise on functional outcomes.

 

Subacute LBP. In 6 studies (total n = 881), 7 exercise groups had a nonexercise comparison group. The trials offered mixed results with regard to evidence of effectiveness, with fair evidence of effectiveness for a graded-exercise activity program as the only notable finding. Pooled data did not show evidence to either support or refute the use of exercise for subacute LBP, either for decreasing pain or improving function.

 

Chronic LBP. There were 43 trials included in this group (total n = 3907). Thirty-three of the studies had nonexercise comparison groups. Exercise was at least as effective as other conservative interventions for LBP, and 2 high-quality studies and 9 lower-quality studies found exercise to be more effective. These studies used individualized exercise programs, focusing mainly on strengthening or trunk stabilization. There were 14 trials that found no difference between exercise and other conservative interventions; of these, 2 were rated highly and 12 rated lower. Pooling the data showed a mean improvement of 10.2 (95% confidence interval [CI], 1.31-19.09) points on a 100-mm pain scale for exercise compared to no treatment and 5.93 (95% CI, 2.21- 9.65) points compared to other conservative treatments. Functional outcomes also showed improvements as follows: 3.0 points at earliest follow-up compared to no treatment (95% CI, ?0.53 to 6.48) and 2.37 points (95% CI, 1.04-3.94) compared to other conservative treatments.

 

Indirect subgroup analysis found that trials examining health care study populations had higher mean improvements in pain and physical functioning compared to their comparison groups or to trials set in occupational or general populations.

 

The review authors offered the following conclusions:

 

  1. In acute LBP, exercises are not more effective than other conservative interventions. Meta-analysis showed no advantage over no treatment of pain and functional outcomes over the short or long-term.
  2. There is fair evidence of effectiveness of a gradedactivity exercise program in subacute LBP in occupational settings. The effectiveness for other types of exercise therapy in other populations is unclear.
  3. In chronic LBP, there is good evidence that exercise is at least as effective as other conservative treatments. Individually designed strengthening or stabilizing programs appear to be effective in health care settings. Meta-analysis found functional outcomes significantly improved; however, the effects were very small, with a less than 3-point (of 100) difference between the exercise and comparison groups at earliest follow-up. Pain outcomes were also significantly improved in groups receiving exercises relative to other comparisons, with a mean of approximately 7 points. Effects were similar over longer follow-up, though confidence intervals increased. Mean improvements in pain and functioning may be clinically meaningful in studies from health care populations in which improvements were significantly greater than those observed in studies from general or mixed populations.

 

The Danish group review of exercise was able to identify 5 systematic reviews and 12 guidelines that discussed exercise for acute LBP, 1 systematic review and 12 guidelines for subacute, and 7 systematic reviews and 11 guidelines for chronic. Furthermore, they identified 1 systematic review that selectively evaluated for postsurgical�cases. Conclusions were essentially the same as the Cochrane review, with the exceptions that there was limited support for McKenzie maneuvers for patients with acute condition and for intensive rehabilitation programs for 4 to 6 weeks after disk surgery over light exercise programs.

 

Natural and Treatment History for LBP

 

Most studies have demonstrated that nearly half of LBP will improve within 1 week, whereas nearly 90% of it will be gone by 12 weeks. Even more, Dixon demonstrated that perhaps as much as 90% of LBP will resolve on its own, without any intervention whatsoever. Von Korff demonstrated that a significant number of patients with acute LBP will have persistent pain if they are observed up to 2 years.

 

Phillips found that nearly 4 of 10 people will have LBP after an episode at 6 months from onset, even if the original pain has disappeared because more than 6 in 10 will have at least 1 relapse during the first year after an episode. These initial relapses occur within 8 weeks most commonly and may reoccur over time, though in decreasing percentages.

 

Workers’ compensation injury patients were observed for 1 year to examine symptom severity and work status. Half of those studied lost no work time in the first month after injury, but 30% did lose time from work due to their injury over the course of 1 year. Of those who missed work in the first month due to their injury and had already been able to return to work, nearly 20% had absence later in that same year. This implies that assessing return to work at 1 month after injury will fail to give an honest depiction of the chronic, episodic nature of LBP. Although many patients have returned to work, they will later experience continuing problems and work-related absences. Impairment present at more than 12 weeks postinjury may be far higher than what has been previously reported in the literature, where rates of 10% are common. In fact, the rates may go up to 3 to 4 times higher.

 

In a study by Schiotzz-Christensen and colleagues, the following was noted. In relation to sick leave, LBP has a favorable prognosis, with a 50% return to work within the first 8 days and only 2% on sick leave after 1 year. However, 15% had been on sick leave during the following year and about half continued to complain of discomfort. This suggested that an acute episode of LBP significant enough to cause the patient to seek a visit to a general practitioner is followed by a longer period of low-grade disability than previously reported. Also, even for those who returned to work, up to 16% indicated that they were not functionally improved. In another study looking at outcomes after 4 weeks after initial diagnosis and treatment, only 28% of patients did not experience any pain. More strikingly, the persistence of pain differed between groups that had radiating pain and those that did not, with 65% of the former feeling improvement at 4 weeks, vs 82% of the latter. The general findings from this study differ from others in that 72% of patients still experienced pain 4 weeks after initial diagnosis.

 

Hestbaek and colleagues reviewed a number of articles in a systematic review. The results showed that the reported proportion of patients who still experienced pain after 12 months after onset was 62% on average, with 16% sick-listed 6 months after onset, and with 60% experiencing relapse of work absence. Also, they found that the mean reported prevalence of LBP in patients who had past episodes of LBP was 56%, compared to just 22% for those who had no such history. Croft and colleagues performed a prospective study looking at the outcomes of LBP in general practice, finding that 90% of patients with LBP in primary care had stopped consulting with symptoms within 3 months; however, most were still experiencing LBP and disability 1 year after the initial visit. Only 25% had fully recovered within that same year.

 

There are even different results in the study by Wahlgren et al. Here, most patients continued to experience pain at both 6 and 12 months (78% and 72%, respectively). Only 20% of the sample had fully recovered by 6 months and only 22% by 12 months.

 

Von Korff has provided a lengthy list of data he considers relevant to assessing the clinical course of back pain as follows: age, sex, race/ethnicity, years of education, occupation, change in occupation, employment status, disability insurance status, litigation status, recency/age at first onset of back pain, recency/age when care was sought, recency of back pain episode, duration of current/most recent episode of back pain, number of back pain days, current pain intensity, average pain intensity, worst pain intensity, ratings of interference with activities, activity limitation days, clinical diagnosis for this episode, bed rest days, work loss days, recency of back pain flare-up, and duration of the most recent flare-up.

 

In a practice-based observational study by Haas et al of almost 3000 patients with acute and chronic condition treated by chiropractors and primary care medical doctors, pain was noted in patients with acute and chronic condition up to 48 months after enrollment. At 36 months, 45% to 75% of patients reported at least 30 days of pain in the prior year, and 19% to 27% of patients with chronic condition recalled daily pain over the previous year.

 

The variability noted in these and many other studies can be explained in part by the difficulty in making an adequate diagnosis, by the different classification schemes used in classifying LBP, by the different outcome tools used in each study and by many other factors. It also points up the extreme difficulty in getting a handle on the day-to-day reality for those who have LBP.

 

Common Markers and Rating Complexity for LBP

 

What Are the Relevant Benchmarks for Evaluating Process of Care?. One benchmark is described above, that being natural history. Complexity and risk stratification are important, as�are cost issues; however, cost-effectiveness is beyond the scope of this report.

 

It is understood that patients with uncomplicated LBP improve faster than those with various complications, the most notable of which is radiating pain. Many factors may influence the course of back pain, including comorbidity, ergonomic factors, age, the level of fitness of the patient, environmental factors, and psychosocial factors. The latter is receiving a great deal of attention in the literature, though as noted elsewhere in this book, such consideration may not be justified. Any of these factors, alone or in combination, may hamper or retard the recovery period after injury.

 

It seems that biomechanical factors play an important role in the incidence of first-time episodes of LBP and its attendant problems such as work loss; psychosocial factors come into play more in subsequent episodes of LBP. The biomechanical factors can lead to tissue tearing, which then create pain and limited ability for years to follow. This tissue damage cannot be seen on standard imaging and may only be apparent upon dissection or surgery.

 

Risk factors for LBP include the following:

 

  • age, sex, severity of symptoms;
  • increased spinal flexibility, decreased muscle endurance;
  • prior recent injury or surgery;
  • abnormal joint motion or decreased body mechanics;
  • prolonged static posture or poor motor control;
  • work-related such as vehicle operation, sustained loads, materials handling;
  • employment history and satisfaction; and
  • wage status.

 

IJzelenberg and Burdorf investigated whether demographic, work-related physical, or psychosocial risk factors involved in the occurrence of musculoskeletal conditions determine subsequent health care use and sick leave. They found that within 6 months, nearly one third of industrial workers with LBP (or neck and upper extremity problems) had a recurrence of sick leave for that same problem and a 40% recurrence of health care use. Work-related factors associated with musculoskeletal symptoms were similar to those associated with health care use and sick leave; but, for LBP, older age and living alone strongly determined whether patients with these problems took any sick leave. The 12- month prevalence of LBP was 52%, and of those with symptoms at baseline, 68% had a recurrence of the LBP. Jarvik and colleagues add depression as an important predictor of new LBP. They found the use of MRI to be a less important predictor of LBP than depression.

 

What Are the Relevant Outcome Measures?. The Clinical Practice Guidelines formulated by the Canadian Chiropractic Association and the Canadian Federation of Chiropractic Regulatory Boards note that there are a number of outcomes that may be used to demonstrate change as a result of treatment. These should be both reliable and valid. According to the Canadian guidelines, appropriate standards are useful in chiropractic practice because they are able to perform the following:

 

  • consistently evaluate the effects of care over time;
  • help indicate the point of maximum therapeutic improvement;
  • uncover problems related to care such as noncompliance;
  • document improvement to the patient, doctor, and third parties;
  • suggest modifications of the goals of treatment if necessary;
  • quantify the clinical experience of the doctor;
  • justify the type, dose, and duration of care;
  • help provide a database for research; and
  • assist in establishing standards of treatment of specific conditions.

 

The broad general classes of outcomes include functional outcomes, patient perception outcomes, physiologic outcomes, general health assessments, and subluxation syndrome outcomes. This chapter addresses only functional and patient perception outcomes assessed by questionnaires and functional outcomes assessed by manual procedures.

 

Functional Outcomes. These are outcomes that measure the patient’s limitations in going about his or her normal daily activities. What is being looked at is the effect of a condition or disorder on the patient (ie, LBP, for which a specific diagnosis may not be present or possible) and its outcome of care. Many such outcome tools exist. Some of the better known include the following:

 

  • Roland Morris Disability Questionnaire,
  • Oswestry Disability Questionnaire,
  • Pain Disability Index,
  • Neck Disability Index,
  • Waddell Disability Index, and
  • Million Disability Questionnaire.

 

These are only some of the existing tools for assessing function.

 

In the existing RCT literature for LBP, functional outcomes have been shown to be the outcome that demonstrates the greatest change and improvement with SMT. Activities of daily living, along with patient selfreporting of pain, were the 2 most notable outcomes to show such improvement. Other outcomes fared less well, including trunk range of motion (ROM) and straight leg raise.

 

In the chiropractic literature, the outcome inventories used most frequently for LBP are the Roland Morris Disability Questionnaire and the Oswestry Questionnaire. In a study in 1992, Hsieh found that both tools provided consistent results over the course of his trial, although the results from the 2 questionnaires differed.

 

Patient Perception Outcomes. Another important set of outcomes involve patient perception of pain and their satisfaction with care. The first involves measuring changes in pain perception over time of its intensity, duration, and frequency. There are a number of valid tools available that can accomplish this, including the following:

 

Visual analog scale�this is a 10-cm line that has pain descriptions noted at both ends of that line representing no pain to intolerable pain; the patient is asked to mark a point on that line that reflects their perceived pain intensity. There are a number of variants for this outcome, including the Numerical Rating Scale (where the patient provides a number between 0 and 10 to represent the amount of pain they have) and the use of pain levels from 0 to 10 depicted pictorially in boxes, which the patient may check. All of these appear to be equally reliable, but for ease of use, either the standard VAS or Numerical Rating Scale is commonly used.

 

Pain diary�these may be used to help monitor a variety of different pain variables (for example, frequency, which the VAS cannot measure). Different forms may be used to collect this information, but it is typically completed on a daily basis.

 

McGill Pain Questionnaire�this scale helps quantify several psychologic components of pain as follows: cognitive-evaluative, motivational-affective, and sensory discriminative. In this instrument, there are 20 categories of words that describe the quality of pain. From the results, 6 different pain variables can be determined.

 

All of the above instruments have been used at various times to monitor the progress of treatment of back pain with SMT.

 

Patient satisfaction addresses both the effectiveness of care as well as the method of receiving that care. There are numerous methods of assessing patient satisfaction, and not all of them were designed to be specifically used for LBP or for manipulation. However, Deyo did develop one for use with LBP. His instrument examines the effectiveness of care, information, and caring. There is also the Patient Satisfaction Questionnaire, which assesses 8 separate indices (such as efficacy/outcomes or professional skill, for example). Cherkin noted that the Visit Specific Satisfaction Questionnaire can be used for chiropractic outcome assessment.

 

Recent work has shown that patient confidence and satisfaction with care are related to outcomes. Seferlis found that patients were more satisfied and felt that they were provided better explanations about their pain from practitioners who used manual therapy. Regardless of treatment, highly satisfied patients at 4 weeks were more likely than less satisfied patients to perceive greater pain improvement throughout 18-month follow-up in a study by Hurwitz et al. Goldstein and Morgenstern found a weak association between treatment confidence in the therapy they received and greater improvement in LBP. A frequent assertion is that benefits observed from application of manipulation methods are a result of physician attention and touching. Studies directly testing this hypothesis were conducted by Hadler et al in patients with acute condition and by Triano et al in patients with subacute and chronic condition. Both studies compared manipulation to a placebo control. In the study of Hadler, the control balanced for provider time attention and frequency, whereas Triano et al also added an education program with home exercise recommendations. In both cases, results demonstrated that although attention given to patients was associated with improvement over time, patients receiving manipulation procedures improved more quickly.

 

General Health Outcome Measures. This has traditionally been a difficult outcome to effectively measure but a number of more recent instruments are demonstrating that it can be done reliably. The 2 major instruments for doing so are the Sickness Impact Profile and the SF-36. The first assesses dimensions such as mobility, ambulation, rest, work, social interaction, and so on; the second looks primarily at well being, functional status, and overall health, as well as 8 other health concepts, to ultimately determine 8 indices that can be used to determine overall health status. Items here include physical functioning, social functioning, mental health, and others. This tool has been used in many settings and has also been adapted into shorter forms as well.

 

Physiologic Outcome Measures. The chiropractic profession has a number of physiologic outcomes that are used with regard to the patient care decision-making process. These include such procedures as ROM testing, muscle function testing, palpation, radiography, and other less common procedures (leg length analysis, thermography, and others). This chapter addresses only the physiologic outcomes assessed manually.

 

Range of Motion. This examination procedure is used by nearly every chiropractor and is used to assess impairment because it is related to spinal function. It is possible to use ROM as a means to monitor improvement in function over time and, therefore, improvement as it relates to the use of SMT. One can assess regional and global lumbar motion, for example, and use that as one marker for improvement.

 

Range of motion can be measured via a number of different means. One can use standard goniometers, inclinometers, and more sophisticated tools that require the use of specialized equipment and computers. When doing so, it is important to consider the reliability of each individual method. A number of studies have assessed various devices as follows:

 

  • Zachman found the use of the rangiometer moderately reliable,
  • Nansel found that using 5 repeated measures of cervical spine motion with an inclinometer to be reliable,
  • Liebenson found that the modified Schrober technique, along with inclinometers and flexible spinal rulers had the best support from the literature,
  • Triano and Schultz found that ROM for the trunk, along with trunk strength ratios and myoelectrical activity, was good indicator for LBP disability, and
  • a number of studies found that the kinematic measurement of ROM for spinal mobility is reliable.

 

Muscle Function. Evaluating muscle function may be done using an automated system or by manual means. Although manual muscle testing has been a common diagnostic practice within the chiropractic profession, there are few studies demonstrating clinical reliability for the procedure, and these are not considered to be of high quality.

 

Automated systems are more reliable and are capable of assessing muscle parameters such as strength, power, endurance, and work, as well as assess different modes of muscle contraction (isotonic, isometric, isokinetic). Hsieh found that a patient-initiated method worked well for specific muscles, and other studies have shown the dynamometer to have good reliability.

 

Leg Length Inequality. Very few studies of leg length have shown acceptable levels of reliability. The best methods for assessing reliability and validity of leg length involve radiographic means and are therefore subject to exposure to ionizing radiation. Finally, the procedure has not been studied as to validity, making the use of this as an outcome questionable.

 

Soft Tissue Compliance. Compliance is assessed by both manual and mechanical means, using the hand alone or using a device such as an algometer. By assessing compliance, the chiropractor is looking to assess muscle tone.

 

Early tests of compliance by Lawson demonstrated good reliability. Fisher found increases in tissue compliance with subjects involved in physical therapy. Waldorf found that prone segmental tissue compliance had good test/retest variation of less than 10%.

 

Pain tolerance assessed using these means has been found reliable, and Vernon found it was a useful measure in assessing the cervical paraspinal musculature after adjusting. The guidelines group from the Canadian Chiropractic Association and the Canadian Federation of Chiropractic Regulatory Boards concluded that �the assessments are safe and inexpensive and appear to be responsive to conditions and treatments commonly seen in chiropractic practice.�

 

Group Portrait Of Workers In Medical Professions

 

Conclusion

 

Existing research evidence regarding the usefulness of spinal adjusting/manipulation/mobilization indicates the following:

 

  1. As much or more evidence exists for the use of SMT to reduce symptoms and improve function in patients with chronic LBP as for use in acute and subacute LBP.
  2. Use of exercise in conjunction with manipulation is likely to speed and improve outcomes as well as minimize episodic recurrence.
  3. There was less evidence for the use of manipulation for patients with LBP and radiating leg pain, sciatica, or radiculopathy.
  4. Cases with high severity of symptoms may benefit by referral for comanagement of symptomswith medication.
  5. There was little evidence for the use of manipulation for other conditions affecting the low back and very few articles to support a higher rating.

 

Exercise and reassurance have been shown to be of value primarily in chronic LBP and low back problems associated with radicular symptoms. A number of standardized, validated tools are available to help capture meaningful clinical improvement over the course of low back care. Typically, functional improvement (as opposed to simple reported reduction in pain levels) may be clinically meaningful for monitoring responses to care. The literature reviewed remains relatively limited in predicting responses to care, tailoring specific combinations of intervention regimens (although the combination of manipulation and exercise may be better than exercise alone), or formulating condition-specific recommendations for frequency and�duration of interventions. Table 2 summarizes the recommendations of the team, based on the review of the evidence.

 

Table 2 Summary of Conclusions

 

Practical Applications

 

  • Evidence exists for the use of spinal manipulation to reduce symptoms and improve function in patients with chronic, acute, and subacute LBP.
  • Exercise in conjunction with manipulation is likely to speed and improve outcomes and minimize recurrence

 

In conclusion,�more evidence-based research studies have become available regarding the effectiveness of chiropractic care for low back pain and sciatica. The article also demonstrated that exercise should be used together with chiropractic to help speed up the rehabilitation process and further improve recovery. In most cases, chiropractic care can be used for the management of low back pain and sciatica, without the need for surgical interventions. However, if surgery is required to achieve recovery, a chiropractor may refer the patient to the next best healthcare professional. Information referenced from the National Center for Biotechnology Information (NCBI). The scope of our information is limited to chiropractic as well as to spinal injuries and conditions. To discuss the subject matter, please feel free to ask Dr. Jimenez or contact us at 915-850-0900 .

 

Curated by Dr. Alex Jimenez

 

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Additional Topics: Sciatica

 

Sciatica is referred to as a collection of symptoms rather than a single type of injury or condition. The symptoms are characterized as radiating pain, numbness and tingling sensations from the sciatic nerve in the lower back, down the buttocks and thighs and through one or both legs and into the feet. Sciatica is commonly the result of irritation, inflammation or compression of the largest nerve in the human body, generally due to a herniated disc or bone spur.

 

blog picture of cartoon paperboy big news

 

IMPORTANT TOPIC: EXTRA EXTRA: Treating Sciatica Pain

 

 

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Close Accordion
Effectiveness of Exercise: Neck, Hip & Knee Injuries from Auto Accidents

Effectiveness of Exercise: Neck, Hip & Knee Injuries from Auto Accidents

Based on statistical findings, approximately more than three million people in the United States are injured in an automobile accident every year. In fact, auto accidents are considered to be one of the most common causes for trauma or injury. Neck injuries, such as whiplash, frequently occur due to the sudden back-and-forth movement of the head and neck from the force of the impact. The same mechanism of injury can also cause soft tissue injuries in other parts of the body, including the lower back as well as the lower extremities. Neck, hip, thigh and knee injuries are common types of injuries resulting from auto accidents.

 

Abstract

 

  • Objective: The purpose of this systematic review was to determine the effectiveness of exercise for the management of soft tissue injuries of the hip, thigh, and knee.
  • Methods: We conducted a systematic review and searched MEDLINE, EMBASE, PsycINFO, the Cochrane Central Register of Controlled Trials, and CINAHL Plus with Full Text from January 1, 1990, to April 8, 2015, for randomized controlled trials (RCTs), cohort studies, and case-control studies evaluating the effect of exercise on pain intensity, self-rated recovery, functional recovery, health-related quality of life, psychological outcomes, and adverse events. Random pairs of independent reviewers screened titles and abstracts and assessed risk of bias using the Scottish Intercollegiate Guidelines Network criteria. Best evidence synthesis methodology was used.
  • Results: We screened 9494 citations. Eight RCTs were critically appraised, and 3 had low risk of bias and were included in our synthesis. One RCT found statistically significant improvements in pain and function favoring clinicbased progressive combined exercises over a �wait and see� approach for patellofemoral pain syndrome. A second RCT suggests that supervised closed kinetic chain exercises may lead to greater symptom improvement than open chain exercises for patellofemoral pain syndrome. One RCT suggests that clinic-based group exercises may be more effective than multimodal physiotherapy in male athletes with persistent groin pain.
  • Conclusion: We found limited high-quality evidence to support the use of exercise for the management of soft tissue injuries of the lower extremity. The evidence suggests that clinic-based exercise programs may benefit patients with patellofemoral pain syndrome and persistent groin pain. Further high-quality research is needed. (J Manipulative Physiol Ther 2016;39:110-120.e1)
  • Key Indexing Terms: Knee; Knee Injuries; Hip; Hip Injuries; Thigh; Thigh Pain; Exercise

 

Soft tissue injuries of the lower limb are common. In the United States, 36% of all injuries presenting to emergency departments are sprains and/or strains of the lower extremity. Among Ontario workers, approximately 19% of all approved lost time compensation claims are related to lower extremity injuries. Moreover, 27.5% of Saskatchewan adults injured in a traffic collision report pain in the lower extremity. Soft tissue injuries of the hip, thigh, and knee are costly and place a significant economic and disability burden on workplaces and compensation systems. According to the US Department of Labor Bureau of Statistics, the median time off work for lower extremity injuries was 12 days in 2013. Knee injuries were associated with the longest work absenteeism (median, 16 days).

 

Most soft tissue injuries of the lower limb are managed conservatively, and exercise is commonly used to treat these injuries. Exercise aims to promote good physical health and restore normal function of the joints and surrounding soft tissues through concepts which include range of motion, stretching, strengthening, endurance, agility, and proprioceptive exercises. However, the evidence about the effectiveness of exercise for managing soft tissue injuries of the lower limb is unclear.

 

Previous systematic reviews have investigated the effectiveness of exercise for the management of soft tissue injuries of the lower extremity. Reviews suggest that exercise is effective for the management of patellofemoral pain syndrome and groin injuries but not for patellar tendinopathy. To our knowledge, the only review reporting on the effectiveness of exercise for acute hamstring injuries found little evidence to support stretching, agility, and trunk stability exercises.

 

Image of trainer demonstrating rehabilitation exercises.

 

The purpose of our systematic review was to investigate the effectiveness of exercise compared to other interventions, placebo/sham interventions, or no intervention in improving self-rated recovery, functional recovery (eg, return to activities, work, or school), or clinical outcomes (eg, pain, health-related quality of life, depression) of patients with soft tissue injuries of the hip, thigh, and knee.

 

Methods

 

Registration

 

This systematic review protocol was registered with the International Prospective Register of Systematic Reviews on March 28, 2014 (CRD42014009140).

 

Eligibility Criteria

 

Population. Our review targeted studies of adults (?18 years) and/or children with soft tissue injuries of the hip, thigh, or knee. Soft tissue injuries include but are not limited to grade I to II sprains/strains; tendonitis; tendinopathy; tendinosis; patellofemoral pain (syndrome); iliotibial band syndrome; nonspecific hip, thigh, or knee pain (excluding major pathology); and other soft tissue injuries as informed by available evidence. We defined the grades of sprains and strains according to the classification proposed by the American Academy of Orthopaedic Surgeons (Tables 1 and 2). Affected soft tissues in the hip include the supporting ligaments and muscles crossing the hip joint into the thigh (including the hamstrings, quadriceps, and adductor muscle groups). Soft tissues of the knee include the supporting intra-articular and extra-articular ligaments and muscles crossing the knee joint from the thigh including the patellar tendon. We excluded studies of grade III sprains or strains, acetabular labral tears, meniscal tears, osteoarthritis, fractures, dislocations, and systemic diseases (eg, infection, neoplasm, inflammatory disorders).

 

Table 1 Case Definition of Sprains

 

Table 2 Case Definition of Strains

 

Interventions. We restricted our review to studies that tested the isolated effect of exercise (ie, not part of a multimodal program of care). We defined exercise as any series of movements aimed at training or developing the body by routine practice or as physical training to promote good physical health.

 

Comparison Groups. We included studies that compared 1 or more exercise interventions to one another or one exercise intervention to other interventions, wait list, placebo/sham interventions, or no intervention.

 

Outcomes. To be eligible, studies had to include one of the following outcomes: (1) self-rated recovery; (2) functional recovery (eg, disability, return to activities, work, school, or sport); (3) pain intensity; (4) health-related quality of life; (5) psychological outcomes such as depression or fear; and (6) adverse events.

 

Study Characteristics. Eligible studies met the following criteria: (1) English language; (2) studies published between January 1, 1990, and April 8, 2015; (3) randomized controlled trials (RCTs), cohort studies, or case-control studies which are designed to assess the effectiveness and safety of interventions; and (4) included an inception cohort of a minimum of 30 participants per treatment arm with the specified condition for RCTs or 100 participants per group with the specified condition in cohort studies or case-control studies. Studies including other grades of sprains or strains in the hip, thigh, or knee had to provide separate results for participants with grades I or II sprains/strains to be included.

 

We excluded studies with the following characteristics: (1) letters, editorials, commentaries, unpublished manuscripts, dissertations, government reports, books and book chapters, conference proceedings, meeting abstracts, lectures and addresses, consensus development statements, or guideline statements; (2) study designs including pilot studies, cross-sectional studies, case reports, case series, qualitative studies, narrative reviews, systematic reviews (with or without meta-analyses), clinical practice guidelines, biomechanical studies, laboratory studies, and studies not reporting on methodology; (3) cadaveric or animal studies; and (4) studies on patients with severe injuries (eg, grade III sprains/strains, fractures, dislocations, full ruptures, infections, malignancy, osteoarthritis, and systemic disease).

 

Information Sources

 

We developed our search strategy with a health sciences librarian (Appendix 1). The Peer Review of Electronic Search Strategies (PRESS) Checklist was used by a second librarian to review the search strategy for completeness and accuracy. We searched MEDLINE and EMBASE, considered to be the major biomedical databases, and PsycINFO, for psychological literature through Ovid Technologies, Inc; CINAHL Plus with Full Text for nursing and allied health literature through EBSCOhost; and the Cochrane Central Register of Controlled Trials through Ovid Technologies, Inc, for any studies not captured by the other databases. The search strategy was first developed in MEDLINE and subsequently adapted to the other bibliographic databases. Our search strategies combined controlled vocabulary relevant to each database (eg, MeSH for MEDLINE) and text words relevant to exercise and soft tissue injuries of the hip, thigh, or knee including grade I to II sprain or strain injuries (Appendix 1). We also hand searched the reference lists of previous systematic reviews for any additional relevant studies.

 

Study Selection

 

A 2-phase screening process was used to select eligible studies. Random pairs of independent reviewers screened citation titles and abstracts to determine the eligibility of studies in phase 1. Screening resulted in studies being classified as relevant, possibly relevant, or irrelevant. In phase 2, the same pairs of reviewers independently screened the possibly relevant studies to determine eligibility. Reviewers met to reach consensus on the eligibility of studies and resolve disagreements. A third reviewer was used if consensus could not be reached.

 

Image of older patient engaging in upper rehabilitation exercises with a personal trainer.

 

Assessment of Risk of Bias

 

Independent reviewers were randomly paired to critically appraise the internal validity of eligible studies using the Scottish Intercollegiate Guidelines Network (SIGN) criteria. The impact of selection bias, information bias, and confounding on the results of a study was qualitatively evaluated using the SIGN criteria. These criteria were used to guide reviewers in making an informed overall judgment on the internal validity of studies. This methodology has been previously described. A quantitative score or a cutoff point to determine the internal validity of studies was not used for this review.

 

The SIGN criteria for RCTs were used to critically appraise the following methodological aspects: (1) clarity of the research question, (2) randomization method, (3) concealment of treatment allocation, (4) blinding of treatment and outcomes, (5) similarity of baseline�characteristics between/among treatment arms, (6) cointervention contamination, (7) validity and reliability of outcome measures, (8) follow-up rates, (9) analysis according to intention-to-treat principles, and (10) comparability of results across study sites (where applicable). Consensus was reached through reviewer discussion. Disagreements were resolved by an independent third reviewer when consensus could not be reached. The risk of bias of each appraised study was also reviewed by a senior epidemiologist (PC). Authors were contacted when additional information was needed to complete the critical appraisal. Only studies with low risk of bias were included in our evidence synthesis.

 

Data Extraction and Synthesis of Results

 

Data were extracted from studies (DS) with low risk of bias to create evidence tables. A second reviewer independently checked the extracted data. We stratified results based on the duration of the condition (recent onset [0-3 months], persistent [N3 months], or variable duration [recent onset and persistent combined]).

 

We used standardized measures to determine the clinical importance of changes reported in each trial for common outcome measures. These include a between-group difference of 2/10 points on the Numeric Rating Scale (NRS), 2/10 cm difference on the Visual Analog Scale (VAS), and 10/100 point difference on the Kujala Patellofemoral scale, otherwise known as the Anterior Knee Pain Scale.

 

Statistical Analyses

 

Agreement between reviewers for the screening of articles was computed and reported using the ? statistic and 95% confidence interval (CI). Where available, we used data provided in the studies with a low risk of bias to measure the association between the tested interventions and the outcomes by computing the relative risk (RR) and its 95% CI. Similarly, we computed differences in mean changes between groups and 95% CI to quantify the effectiveness of interventions. The calculation of 95% CIs was based on the assumption that baseline and follow-up outcomes were highly correlated (r = 0.80).

 

Reporting

 

This systematic review was organized and reported based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement.

 

Dr. Alex Jimenez’s Insight

As a doctor of chiropractic, automobile accident injuries are one of the most common reasons people seek chiropractic care. From neck injuries, such as whiplash, to headaches and back pain, chiropractic can be utilized to safely and effectively restore the integrity of the spine after a car crash. A chiropractor like myself will often use a combination of spinal adjustments and manual manipulations, as well as a variety of other non-invasive treatment methods,�to gently correct any spinal misalignments resulting from an auto accident injury. Whiplash and other types of neck injuries occur when the complex structures along the cervical spine are stretched beyond their natural range of movement due to the sudden back-and-forth movement of the head and neck from the force of the impact. Back injury, particularly in the lower spine, are also common as a result of an automobile accident. When the complex structures along the lumbar spine are damaged or injured, symptoms of sciatica may radiate down the lower back, into the buttocks, hips, thighs, legs and down into the feet. Knee injuries may also occur upon impact during an auto accident. Exercise is frequently used with chiropractic care to help promote recovery as well as improve strength, flexibility and mobility. Rehabilitation exercises are offered to patients to further restore the integrity of their body. The following research studies demonstrate that exercise, compared to non-invasive treatment options, is a safe and effective treatment method for individuals suffering with neck and lower extremity injury from a car crash.

 

Results

 

Study Selection

 

We screened 9494 citations based on the title and abstract (Figure 1). Of these, 60 full-text publications were screened, and 9 articles were critically appraised. The primary reasons for ineligibility during full text screening were (1) ineligible study design, (2) small sample size (n b 30 per treatment arm), (3) multimodal interventions not allowing isolation of the effectiveness of exercise, (4) ineligible study population, and (5) interventions not meeting our definition of exercise (Figure 1). Of those critically appraised, 3 studies (reported in 4 articles) had low risk of bias and were included in our synthesis. The interrater agreement for the screening of the articles was ? = 0.82 (95% CI, 0.69-0.95). The percentage agreement for the critical appraisal of studies was 75% (6/8 studies). Disagreement was resolved through discussion for 2 studies. We contacted authors from 5 studies during critical appraisal to request additional information and 3 responded.

 

Figure 1 Flowchart Used for the Study

 

Study Characteristics

 

The studies with low risk of bias were RCTs. One study, conducted in the Netherlands, examined the effectiveness of a standardized exercise program compared to a �wait and see� approach in participants with patellofemoral pain syndrome of variable duration. A second study, with outcomes reported in 2 articles, compared the benefit of closed vs open kinetic chain exercises in individuals with�variable duration patellofemoral pain syndrome in Belgium. The final study, conducted in Denmark, investigated active training compared to a multimodal physiotherapy intervention for the management of persistent adductor-related groin pain.

 

Two RCTs used exercise programs that combined strengthening exercises with balance or agility training for the lower extremity. Specifically, the strengthening exercises consisted of both isometric and concentric contractions of the quadriceps, hip adductor, and gluteal muscles for the management of patellofemoral pain46 and hip adductors and muscles of the trunk and pelvis for adductor-related groin pain. The exercise programs ranged from 646 to 1243 weeks in duration and were supervised and clinic based with additional daily home exercises. The exercise programs were compared to a �wait and see� approach or to multimodal physiotherapy. The third RCT compared 2 different 5-week protocols which combined either closed or open kinetic chain strengthening and stretching exercises for the lower extremity musculature.

 

Meta-analysis was not performed due to heterogeneity of accepted studies with respect to patient populations, interventions, comparators, and outcomes. Principles of best evidence synthesis were used to develop evidence statements and perform a qualitative synthesis of findings from studies with low risk of bias.

 

Risk of Bias Within Studies

 

The studies with low risk of bias had a clearly defined research question, used appropriate blinding methods where possible, reported adequate similarity of baseline characteristics between treatment arms, and performed an intention-to-treat analyses where applicable (Table 3). The RCTs had follow-up rates greater than 85%. However, these studies also had methodological limitations: insufficient detail describing methods for allocation concealment (1/3), insufficient detail describing methods of randomization (1/3), the use of outcome measures that have not been demonstrated to be valid or reliable (ie, muscle length and successful treatment) (2/3), and clinically important differences in baseline characteristics (1/3).

 

Table 3 Risk of Bias for Accepted Randomized Control Trials Based on SIGN Criteria

 

Of 9 relevant articles, 5 were deemed to have high risk of bias. These studies had the following limitations: (1) poor or unknown randomization methods (3/5); (2) poor or unknown allocation concealment methods (5/ 5); (3) outcome assessor not blinded (4/ 5); (4) clinically important differences in baseline characteristics (3/5); (5) dropouts not reported, insufficient information regarding dropouts per group or large differences in dropout rates between treatment arms (N15%) (3/5); and (6) a lack of information about or no intention-to-treat analysis (5/5).

 

Summary of Evidence

 

Patellofemoral Pain Syndrome of Variable Duration. Evidence from 1 RCT suggests that a clinic-based progressive exercise program may provide short- and long-term benefit over usual care for the management of patellofemoral pain syndrome of variable duration. van Linschoten et al randomized participants with a clinical diagnosis of patellofemoral pain syndrome of 2 months to 2 years duration to (1) a clinic-based exercise program (9 visits over 6 weeks) consisting of progressive, static, and dynamic strengthening exercises for the quadriceps, adductor, and gluteal muscles and balance and flexibility exercises, or (2) a usual care �wait and see� approach. Both groups received standardized information, advice, and home-based isometric exercises for the quadriceps based on recommendations from Dutch General Practitioner guidelines (Table 4). There�were statistically significant differences favoring the exercise group for (1) pain (NRS) at rest at 3 months (mean change difference 1.1/10 [95% CI, 0.2-1.9]) and 6 months (mean change difference 1.3/10 [95% CI, 0.4-2.2]); (2) pain (NRS) with activity at 3 months (mean change difference 1.0/10 [95% CI, 0.1-1.9]) and 6 months (mean change difference 1.2/10 [95% CI, 0.2-2.2]); and (3) function (Kujala Patellofemoral Scale [KPS]) at 3 months (mean change difference 4.9/100 [95% CI, 0.1-9.7]). However, none of these differences were clinically important. Furthermore, there were no significant differences in the proportion of participants reporting recovery (fully recovered, strongly recovered), but the exercise group was more likely to report improvement at 3-month follow-up (odds ratio [OR], 4.1 [95% CI, 1.9-8.9]).

 

Image of patient engaging in rehabilitation exercises.

 

Evidence from a second RCT suggests that physiotherapist- supervised closed kinetic chain leg exercises (where the foot remains in constant contact with a surface) may provide short-term benefit compared to supervised open kinetic chain exercises (where the limb moves freely) for some patellofemoral pain syndrome symptoms (Table 4). All participants trained for 30 to 45 minutes, 3 times per week for 5 weeks. Both groups were instructed to perform static lower limb stretching after each training session. Those randomized to closed chain exercises performed supervised (1) leg presses, (2) knee bends, (3) stationary biking, (4) rowing, (5) step-up and step-down exercises, and (6) progressive jumping exercises. Open chain exercise participants performed (1) maximal quad muscle contraction, (2) straight-leg raises, (3) short arc movements from 10� to full knee extension, and (4) leg adduction. Effect sizes were not reported, but the authors reported statistically significant differences favoring closed kinetic chain exercise at 3 months for (1) frequency of locking (P = .03), (2) clicking sensation (P = .04), (3) pain with isokinetic testing (P = .03), and (4) pain during night (P = .02). The clinical significance of these results is unknown. There were no statistically significant differences between groups for any other pain or functional measures at any follow-up period.

 

Table 4 Evidence Table for Accepted Randomized Control Trials on the Effectiveness of Exercise for Soft Tissue Injuries of the Hip, Thigh, or Knee

 

Table 4 Evidence Table for Accepted Randomized Control Trials on the Effectiveness of Exercise for Soft Tissue Injuries of the Hip, Thigh, or Knee

 

Persistent Adductor-Related Groin Pain

 

Evidence from 1 RCT suggests that a clinic-based group exercise program is more effective than a multimodal program of care for persistent adductor-related groin pain. H�lmich et al studied a group of male athletes with a clinical diagnosis of adductor-related groin pain of greater than 2 months duration (median duration, 38-41 weeks; range, 14-572 weeks) with or without osteitis pubis. Participants were randomized to (1) a clinic-based group exercise program (3 sessions per week for 8-12 weeks) consisting of isometric and concentric resistance strengthening exercises for the adductors, trunk, and pelvis; balance and agility exercises for the lower extremity; and stretching for the abdominals, back, and lower extremity (with the exception of the adductor muscles) or (2) a multimodal physiotherapy program (2 visits per week for 8-12 weeks) consisting of laser; transverse friction massage; transcutaneous electrical nerve stimulation (TENS); and stretching for the adductors, hamstrings, and hip flexors (Table 4). Four months after the intervention, the exercise group was more likely to report that their condition was �much better� (RR, 1.7 [95% CI, 1.0-2.8]).

 

Adverse Events

 

None of the included studies commented on the frequency or nature of adverse events.

 

Discussion

 

Summary of Evidence

 

Our systematic review examined the effectiveness of exercise for the management of soft tissue injuries of the hip, thigh, or knee. Evidence from 1 RCT suggests that a clinic-based progressive combined exercise program may offer additional short- or long-term benefit compared to providing information and advice for the management of patellofemoral pain syndrome of variable duration. There is also evidence that supervised closed kinetic chain exercises may be beneficial for some patellofemoral pain syndrome symptoms compared to open kinetic chain exercises. For persistent adductor-related groin pain, evidence from 1 RCT suggests that a clinic-based group exercise program is more effective than a multimodal program of care. Despite the common and frequent use of exercise prescription, there is limited high-quality evidence to inform the use of exercise for the management of soft tissue injuries of the lower extremity. Specifically, we did not find high-quality studies on exercise for the management of some of the more commonly diagnosed conditions including patellar tendinopathy, hamstring sprain and strain injuries, hamstring tendinopathy, trochanteric bursitis, or capsular injuries of the hip.

 

Image of Dr. Jimenez demonstrating rehabilitation exercises to patient.

 

Previous Systematic Reviews

 

Our results are consistent with findings from previous systematic reviews, concluding that exercise is effective for the management of patellofemoral pain syndrome and groin pain. However, the results from previous systematic reviews examining the use of exercise for the management of patellar tendinopathy and acute hamstring injuries are inconclusive. One review noted strong evidence for use of eccentric training, whereas others reported uncertainty of whether isolated eccentric exercises were beneficial for tendinopathy compared to other forms of exercise. Furthermore, there is limited evidence of a positive effect from stretching, agility and trunk stability exercises, or slump stretching for the management of acute�hamstring injuries. Differing conclusions between systematic reviews and the limited number of studies deemed admissible in our work may be attributed to differences in methodology. We screened reference lists of previous systematic reviews, and most studies included in the reviews did not meet our inclusion criteria. Many studies accepted in other reviews had small sample sizes (b30 per treatment arm). This increases the risk of residual confounding while also reducing the effect size precision. Furthermore, a number of systematic reviews included case series and case studies. These types of studies are not designed to assess the effectiveness of interventions. Finally, previous reviews included studies where exercise was part of a multimodal intervention, and as a consequence, the isolated effect of exercise could not be ascertained. Of the studies that satisfied our selection criteria, all were critically appraised in our review, and only 3 had low risk of bias and were included in our synthesis.

 

Strengths

 

Our review has many strengths. First, we developed a rigorous search strategy that was independently reviewed by a second librarian. Second, we defined clear inclusion and exclusion criteria for the selection of possibly relevant studies and only considered studies with adequate sample sizes. Third, pairs of trained reviewers screened and critically appraised eligible studies. Fourth, we used a valid set of criteria (SIGN) to critically appraise studies. Finally, we restricted our synthesis to studies with low risk of bias.

 

Limitations and Recommendations for Future Research

 

Our review also has limitations. First, our search was limited to studies published in the English language. However, previous reviews have found that the restriction of systematic reviews to English language studies has not led to a bias in reported results. Second, despite our broad definition of soft tissue injuries of the hip, thigh, or knee, our search strategy may not have captured all potentially relevant studies. Third, our review may have missed potentially relevant studies published before 1990. We aimed to minimize this by hand searching the reference lists of previous systematic reviews. Finally, critical appraisal requires scientific judgment that may differ between reviewers. We minimized this potential bias by training reviewers in the use of the SIGN tool and using a consensus process to determine study admissibility. Overall, our systematic review highlights a deficit of strong research in this area.

 

High-quality studies on the effectiveness of exercise for the management of soft tissue injuries of the lower extremity are needed. Most studies included in our review (63%) had a high risk of bias and could not be included in our synthesis. Our review identified important gaps in the literature. Specifically, studies are needed to inform the specific effects of exercises, their long-term effects, and the optimal doses of intervention. Furthermore, studies are needed to determine the relative effectiveness of different types of exercise programs and if the effectiveness varies for soft tissue injuries of the hip, thigh, and knee.

 

Conclusion

 

There is limited high-quality evidence to inform the use of exercise for the management of soft tissue injuries of the hip, thigh, and knee. The current evidence suggests that a clinic-based progressive combined exercise program may lead to improved recovery when added to information and advice on resting and avoiding pain provoking activities for the management of patellofemoral pain syndrome. For persistent adductor-related groin pain, a supervised clinic- based group exercise program is more effective than multimodal care in promoting recovery.

 

Funding Sources and Potential Conflicts of Interest

 

This study was funded by the Ontario Ministry of Finance and the Financial Services Commission of Ontario (RFP no. OSS_00267175). The funding agency was not involved in the collection of data, data analysis, interpretation of data, or drafting of the manuscript. The research was undertaken, in part, thanks to funding from the Canada Research Chairs program. Pierre C�t� has previously received funding from a Grant from the Ontario Ministry of Finance; consulting for the Canadian Chiropractic Protective Association; speaking and/or teaching arrangements for the National Judicial Institute and Soci�t� des M�decins Experts du Quebec; trips/travel, European Spine Society; board of directors, European Spine Society; grants: Aviva Canada; fellowship support, Canada Research Chair Program�Canadian Institutes of Health Research. No other conflicts of interest were reported for this study.

 

Contributorship Information

 

  • Concept development (provided idea for the research): D.S., C.B., P.C., J.W., H.Y., S.V.
  • Design (planned the methods to generate the results): D.S., C.B., P.C., H.S., J.W., H.Y., S.V.
  • Supervision (provided oversight, responsible for organization and implementation, writing of the manuscript): D.S., P.C.
  • Data collection/processing (responsible for experiments, patient management, organization, or reporting data): D.S., C.B., H.S., J.W., D.e.S., R.G., H.Y., K.R., J.C., K.D., P.C., P.S., R.M., S.D., S.V.
  • Analysis/interpretation (responsible for statistical analysis, evaluation, and presentation of the results): D.S., C.B., P.C., H.S., M.S., K.R., L.C.
  • Literature search (performed the literature search): A.T.V.
  • Writing (responsible for writing a substantive part of the manuscript): D.S., C.B., P.C., H.S.
  • Critical review (revised manuscript for intellectual content, this does not relate to spelling and grammar checking): D.S., P.C., H.S., J.W., D.e.S., R.G., M.S., A.T.V., H.Y., K.R., J.C., K.D., L.C., P.S., S.D., R.M., S.V.

 

Practical Applications

 

  • There is evidence to suggest that clinic-based exercises may benefit patients with patellofemoral pain syndrome or adductor-related groin pain.
  • Supervised progressive exercises may be beneficial for patellofemoral pain syndrome of variable duration compared to information/advice.
  • Supervised closed kinetic chain exercises may provide more benefit compared to open kinetic chain exercises for some patellofemoral pain syndrome symptoms.
  • Self-rated improvement in persistent groin pain is higher after a clinic-based group exercise program compared to multimodal physiotherapy.

 

Are Non-Invasive Interventions Effective for the Management of Headaches Associated with Neck Pain?

 

Furthermore,�other non-invasive interventions, as well as non-pharmacological interventions, are also commonly utilized to help treat symptoms of neck pain and headaches associated with neck injuries, such as whiplash, caused by automobile accidents. As mentioned before, whiplash is one of the most common types of neck injuries resulting from auto accidents. Chiropractic care, physical therapy and exercise, can be used to improve the symptoms of neck pain, according to the following research studies.

 

Abstract

 

Purpose

 

To update findings of the 2000�2010 Bone and Joint Decade Task Force on Neck Pain and its Associated Disorders and evaluate the effectiveness of non-invasive and non-pharmacological interventions for the management of patients with headaches associated with neck pain (i.e., tension-type, cervicogenic, or whiplash-related headaches).

 

Methods

 

We searched five databases from 1990 to 2015 for randomized controlled trials (RCTs), cohort studies, and case�control studies comparing non-invasive interventions with other interventions, placebo/sham, or no interventions. Random pairs of independent reviewers critically appraised eligible studies using the Scottish Intercollegiate Guidelines Network criteria to determine scientific admissibility. Studies with a low risk of bias were synthesized following best evidence synthesis principles.

 

Results

 

We screened 17,236 citations, 15 studies were relevant, and 10 had a low risk of bias. The evidence suggests that episodic tension-type headaches should be managed with low load endurance craniocervical and cervicoscapular exercises. Patients with chronic tension-type headaches may also benefit from low load endurance craniocervical and cervicoscapular exercises; relaxation training with stress coping therapy; or multimodal care that includes spinal mobilization, craniocervical exercises, and postural correction. For cervicogenic headaches, low load endurance craniocervical and cervicoscapular exercises; or manual therapy (manipulation with or without mobilization) to the cervical and thoracic spine may also be helpful.

 

Image of elderly couple participating in low-impact rehabilitation exercises.

 

Conclusions

 

The management of headaches associated with neck pain should include exercise. Patients who suffer from chronic tension-type headaches may also benefit from relaxation training with stress coping therapy or multimodal care. Patients with cervicogenic headache may also benefit from a course of manual therapy.

 

Keywords

 

Non-invasive interventions, Tension-type headache, Cervicogenic headache, Headache attributed to whiplash injury, Systematic review

 

Notes

 

Acknowledgments

 

We would like to acknowledge and thank all of the individuals who have made important contributions to this review: Robert Brison, Poonam Cardoso, J. David Cassidy, Laura Chang, Douglas Gross, Murray Krahn, Michel Lacerte, Gail Lindsay, Patrick Loisel, Mike Paulden, Roger Salhany, John Stapleton, Angela Verven, and Leslie Verville. We would also like to thank Trish Johns-Wilson at the University of Ontario Institute of Technology for her review of the search strategy.

 

Compliance with Ethical Standards

 

Conflict of Interest

 

Dr. Pierre C�t� has received a grant from the Ontario government, Ministry of Finance, funding from the Canada Research Chairs program, personal fees from National Judicial Institute for lecturing, and personal fees from European Spine Society for teaching. Drs. Silvano Mior and Margareta Nordin have received reimbursement for travel expenses to attend meetings for the study. The remaining authors report no declarations of interest.

 

Funding

 

This work was supported by the Ontario Ministry of Finance and the Financial Services Commission of Ontario [RFP# OSS_00267175]. The funding agency had no involvement in the study design, collection, analysis, interpretation of data, writing of the manuscript or decision to submit the manuscript for publication. The research was undertaken, in part, thanks to funding from the Canada Research Chairs program to Dr. Pierre C�t�, Canada Research Chair in Disability Prevention and Rehabilitation at the University of Ontario Institute of Technology.

 

In conclusion,�exercise included in chiropractic care and other non-invasive interventions should be utilized as an essential part of treatment to further help improve the symptoms of neck injury as well as that of hip, thigh and knee injury. According to the above research studies, exercise, or physical activity, is beneficial towards speeding up recovery time for patients with automobile accident injuries and for restoring strength, flexibility and mobility to the affected structures of the spine. Information referenced from the National Center for Biotechnology Information (NCBI). The scope of our information is limited to chiropractic as well as to spinal injuries and conditions. To discuss the subject matter, please feel free to ask Dr. Jimenez or contact us at 915-850-0900 .

 

Curated by Dr. Alex Jimenez

 

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Additional Topics: Sciatica

 

Sciatica is referred to as a collection of symptoms rather than a single type of injury or condition. The symptoms are characterized as radiating pain, numbness and tingling sensations from the sciatic nerve in the lower back, down the buttocks and thighs and through one or both legs and into the feet. Sciatica is commonly the result of irritation, inflammation or compression of the largest nerve in the human body, generally due to a herniated disc or bone spur.

 

blog picture of cartoon paperboy big news

 

IMPORTANT TOPIC: EXTRA EXTRA: Treating Sciatica Pain

 

 

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Close Accordion
Chiropractic Care: 5 Reasons For Whiplash Sufferers

Chiropractic Care: 5 Reasons For Whiplash Sufferers

Chiropractic Care: Our neck is a busy body part. It holds up and turns our head, allowing us to see, hear, and speak in the direction we choose.

Although the neck is a real “team player” it’s a bit of a diva, meaning it’s fairly delicate. There are many ways everyday motion injures the neck, ending up causing pain, decreased mobility, and varying degrees of short and long-term misery.

Whiplash is a common neck injury caused by a sudden movement that jerks the neck forth and then back in a whipping motion. Automobile accidents frequently result in whiplash, as the vehicle is moving and then stopping rapidly.

This affects the neck’s ligaments and joints in various degrees, depending on the speed of the vehicle and the site of the impact. In severe cases, the discs and the nerves may also be damaged.

Symptoms of whiplash include varying degrees of pain, stiffness in the neck, headaches, and sometimes dizziness, blurred vision, and nausea. Some people only suffer with whiplash a few days, while others experience ongoing issues.

If you have been injured in an automobile crash, it’s in your best interest to immediately schedule an appointment with a chiropractor. There are a myriad of ways chiropractic care assists in managing the pain and minimizing the symptoms of whiplash.

Here Are The 5 Best Reasons For Chiropractic Care:

chiropractic care#1: Reduces Inflammation To Promote Healing

The first order of business for whiplash sufferers is to get the neck’s inflammation reduced, as this hinders proper healing. Your chiropractor will utilize chiropractic adjustments, along with other forms of treatment based on your specific injury. It�s essential to undergo this type of treatment as soon after the injury occurs as possible in order to reach optimum results.

#2: Minimizes Pain For Greater Comfort

Whiplash can be extremely painful, as so many of the neck’s components may be involved, and the neck is such a mobile body part. Every neck movement hurting is no way to live! Chiropractic care soothes the pain of whiplash through therapeutic techniques that promote healing of the damaged area.

#3: Returns Proper Body Alignment

When the inflammation and the pain of whiplash are reduced, the next step is to promote healing and alignment within the body. A chiropractor will perform a series of chiropractic adjustments that includes the neck and spine, but may also incorporate other parts of the body. Whiplash does a number on the body’s natural alignment, and it’s the chiropractor’s job to put it all back together in workable order.

#4: Offers Exercises To Increase Mobility

Contrary to old movies where the whiplash sufferer wears a cumbersome neck brace, it’s vital to the rehabilitation process to keep moving. During chiropractic visits, patients receive a regimen of exercises to perform regularly at home. These, combined with chiropractic care, lessen the time it takes to recover.

#5: Provides An Alternative To Surgery

The good news is that a whiplash injury rarely requires surgery. However, it’s best to not tempt fate and visit a chiropractor to make certain your injuries are treated and begin healing. A chiropractor monitors improvements and keeps you apprised of your progress, empowering you to get better and back to normal activity faster than simply suffering through the symptoms, hoping they go away.

If you are involved in a motor vehicle crash and end up with whiplash, don’t despair. A chiropractor will map out a treatment regimen that will decrease inflammation and pain, increase mobility, and promote healing. Remember, the sooner you see your chiropractor, the faster the treatment begins, and the sooner you see results. Don’t suffer needlessly!

Chiropractic Care & Headaches

This article is copyrighted by Blogging Chiros LLC for its Doctor of Chiropractic members and may not be copied or duplicated in any manner including printed or electronic media, regardless of whether for a fee or gratis without the prior written permission of Blogging Chiros, LLC.

Functional Fitness & Chiropractic Care for Back Pain

Functional Fitness & Chiropractic Care for Back Pain

In association with professional experience in fitness and chiropractic care,�symptoms of back pain have been determined to improve in people who participate in physical activity and exercise, as directed by a physiotherapist, or physical therapist, or any other healthcare professional, such as a chiropractor. Various complementary and alternative treatment options for back pain also involve the use of functional fitness therapy, however, additional evidence-based research studies on the effectiveness of physical activity and exercise are still needed.

 

On a personal note, chiropractic care utilizes spinal adjustments and manual manipulations to carefully correct misalignments on the spine, or spinal subluxations. Along with chiropractic treatment, a doctor of chiropractor may also recommend a series of stretches and exercises to help increase flexibility, strength and mobility, improving the overall function of the spine. Physical activity for low back pain has been evaluated in the randomized controlled trial below.

Abstract

 

Objective

 

To evaluate effectiveness of an exercise programme in a community setting for patients with low back pain to encourage a return to normal activities.

 

Design

 

Randomised controlled trial of progressive exercise programme compared with usual primary care management. Patients� preferences for type of management were elicited independently of randomisation.

 

Participants

 

187 patients aged 18-60 years with mechanical low back pain of 4 weeks to 6 months� duration.

 

Interventions

 

Exercise classes led by a physiotherapist that included strengthening exercises for all main muscle groups, stretching exercises, relaxation session, and brief education on back care. A cognitive-behavioural approach was used.

 

Main Outcome Measures

 

Assessments of debilitating effects of back pain before and after intervention and at 6 months and 1 year later. Measures included Roland disability questionnaire, Aberdeen back pain scale, pain diaries, and use of healthcare services.

 

Results

 

At 6 weeks after randomisation, the intervention group improved marginally more than the control group on the disability questionnaire and reported less distressing pain. At 6 months and 1 year, the intervention group showed significantly greater improvement in the disability questionnaire score (mean difference in changes 1.35, 95% confidence interval 0.13 to 2.57). At 1 year, the intervention group also showed significantly greater improvement in the Aberdeen back pain scale (4.44, 1.01 to 7.87) and reported only 378 days off work compared with 607 in the control group. The intervention group used fewer healthcare resources. Outcome was not influenced by patients� preferences.

 

Conclusions

 

The exercise class was more clinically effective than traditional general practitioner management, regardless of patient preference, and was cost effective.

 

Key Messages

 

  • Patients with back pain need to return to normal activities as soon as possible but are often afraid that movement or activity may be harmful
  • An exercise programme led by a physiotherapist in the community and based on cognitive-behavioural principles helped patients to cope better with their pain and function better even one year later
  • Patients� preferences for type of management did not affect outcome
  • Patients in the intervention group tended to use fewer healthcare resources and took fewer days off work
  • This type of exercise programme should be more widely available

 

Introduction

 

Low back pain is common and, although it may settle quickly, recurrence rates are about 50% in the following 12 months. Recent management guidelines recommend that an early return to physical activities should be encouraged, but patients are often afraid of movement after an acute onset of back pain. Trials of specific exercise programmes for acute back pain have not shown them to be effective, but a specific exercise programme may have to be tailored to suit the individual patient and so is less likely to be effective for a heterogeneous group of patients.

 

However, there is some evidence that a general exercise programme, which aims to increase individuals� confidence in the use of their spine and overcome the fear of physical activity, can be effective for patients with chronic back pain (of more than six months� duration). A recent randomised trial of a supervised exercise programme in a hospital setting reported significantly better outcomes at six months and two years for the exercise group compared with the control group. Whether this approach would be effective and cost effective for patients with low back pain of less than six months� duration in a primary care setting is unknown.

 

Image 1 Exercise Classes for Back Pain

 

An important methodological problem occurs when it is not possible to blind subjects to the treatment they receive, since outcome is probably directly influenced by their preconceived ideas regarding the effectiveness of intervention. Thus, in trials where a double blind procedure is not feasible, participants who are not randomised to their treatment of choice may be disappointed and suffer from resentful demoralisation, whereas those randomised to their preferred treatment may have a better outcome irrespective of the physiological efficacy of the intervention. However, this problem may be partly ameliorated if patients� treatment preferences are elicited before randomisation, so that they can be used to inform the analysis of costs and outcomes.

 

In this paper, we report a fully randomised trial for the treatment of subacute low back pain in which the analysis was informed by patient preference.

 

Subjects and Methods

 

Recruitment of Subjects

 

Eighty seven general practitioners agreed to participate in the study, and the principal investigator (JKM) visited each practice to discuss participation. Selection of general practitioners was based in the York area and restricted by the need to provide easy access for patients to the classes. Only one invited practice declined to participate. Single handed practices were not invited. The general practitioners referred patients directly to the research team or sent a monthly list of patients who had consulted with back pain. Inclusion criteria were patients with mechanical low back pain of at least four weeks� duration but less than six months, aged between 18 and 60, declared medically fit by their general practitioner to undertake the exercise, and who had consulted one of the general practitioners participating in the study. Patients with any potentially serious pathology were excluded, as were any who would have been unable to attend or participate in the classes. The exclusion criteria were the same as described by Frost et al except that concurrent physiotherapy rather than previous physiotherapy was an exclusion criterion in this trial.

 

Evaluation

 

Patients who seemed eligible were contacted by telephone and if they were interested in participating in the study were invited to an initial interview, at which the study and its implications for participants were explained. Patients who met all the eligibility criteria and consented to participate attended a first assessment a week later.

 

Image 2 Physical Examination for Back Pain

 

This included a physical examination (to exclude possible serious spinal pathology) and collection of baseline data by means of validated measures of health status. The main outcome measures were the Roland back pain disability questionnaire, which measures functional limitations due to back pain, and the Aberdeen back pain scale, which is more a measure of clinical status. The Roland disability questionnaire consists of a 24 point scale: a patient scoring three points on the scale means that he or she reports, for example, �Because of my back I am not doing any of the jobs that I usually do around the house, I use a handrail to get upstairs, and I lie down to rest more often.� We also administered the EuroQoL health index (EQ-5D) and the fear and avoidance beliefs questionnaire (FABQ).

 

The second assessment was carried out at the patients� general practice six weeks after randomisation to treatment. The brief physical examination was repeated, and the patients were asked to complete the same outcome questionnaires.

 

In addition, patients were asked to complete pain diaries in the week before their first assessment and in the week before their second assessment. The diaries were used to assess subjective pain reports and asked �How strong is the pain?� and �How distressing is the pain?�

 

We also evaluated patients at six and 12 months� follow up by sending them outcome questionnaires to complete and return.

 

Randomisation and Treatments

 

A pre-prepared randomisation list was generated from a random numbers table and participants were stratified by practice in blocks of six. The trial coordinator ensured concealment of allocation from the clinical researchers by providing the research physiotherapist with a sealed envelope for a named patient before baseline assessment. A note inside the envelope invited the participant either to attend exercise classes or to continue with the current advice or treatment offered by his or her general practitioner. (One of the referring general practitioners used manipulation as usual treatment on most of his patients so that up to 37 patients in each arm of the study could also have received manipulation.) Each patient had an equal chance of being allocated to the intervention or the control group. Before patients were given their envelope they were asked whether they had any preference for the treatment assignment. The participants opened the envelope after leaving the surgery.

 

Intervention group�The exercise programme consisted of eight sessions, each lasting an hour, spread out over four weeks, with up to 10 participants in each class. The programme was similar to the Oxford fitness programme and included stretching exercises, low impact aerobic exercises, and strengthening exercises aimed at all the main muscle groups. The overall aim was to encourage normal movement of the spine. No special equipment was needed. Participants were discouraged from viewing themselves as invalids and from following the precept of �Let pain be your guide.� They were encouraged to improve their individual record and were selectively rewarded with attention and praise. Although partly based on a traditional physiotherapy approach, the programme used cognitive-behavioural principles. One simple educational message encouraging self reliance was delivered at each class. Participants were told that they should regard the classes as a stepping stone to increasing their own levels of activity.

 

Controls�Patients allocated to the control group continued under the care of their doctor and in some cases were referred to physiotherapy as usual. No attempt was made to regulate the treatment they received, but it was recorded.

 

Economic Analysis

 

We recorded patients� use of healthcare services using a combination of retrospective questionnaires and prospective diary cards, which they returned at 6 and 12 months� follow up. From this information we estimated the cost of each patient�s treatment. We compared the mean costs of treatment for the two groups by using Student�s t tests and standard confidence intervals. However, as cost data were highly positively skewed, these results were checked with a non-parametric �bootstrap.� The economic evaluation addressed both costs to the NHS and the costs to society. Participants were not charged for the classes, in line with any treatment currently available on the NHS.

 

Statistical Analysis

 

Our original intention was to recruit 300 patients, which, given a standard deviation of 4, would have provided 90% power at the 5% significance level to detect a 1.5 point difference between the two groups in the mean change on the Roland disability questionnaire. However, recruitment of patients to the study proved much slower than expected, and, because of the limitations of study resources, recruiting was stopped after 187 patients had been included into the study. This smaller sample reduced the power to detect such a difference to 72%, but there was still 90% power to detect a 2 point difference in outcome.

 

Our analysis was based on intention to treat. We estimated the effects of treatment on the outcome measures by means of analysis of covariance, with the change in scores as the dependent variable and adjustment being made for baseline score and patient preference. We used Student�s t tests to analyse the data from the pain diaries as the baseline scores were quite similar.

 

Dr. Alex Jimenez’s Insight

In consideration with the research study regarding a randomized controlled trial coordinated to determine the effectiveness of functional fitness towards the improvement of low back pain, we supplement our philosophies of overall health and wellness to our patients and we make sure to take their recovery and rehabilitation to the next level. Our fitness and chiropractic care treatment goes beyond many other medically advanced methods. The proprietary treatment methods offered at our clinic promote true well-being and fitness practices with a primary goal on the calibration of the human body. The outcome measures of the randomized controlled trial on exercise for low back pain involved two groups of participants, an intervention group and a control group. The results are recorded below.

 

Results

 

Study Population

 

Of the 187 patients included in the trial, 89 were randomised to the intervention and 98 to the control group. The figure shows their progress through the trial. In both groups those with the most severe back pain at randomisation were less likely to return follow up questionnaires: the mean Roland disability questionnaire score for responders at one year follow up was 5.80 (SD 3.48) compared with a mean score of 9.06 (4.58) for non responders respectively (P=0.002).

 

Baseline Characteristics

 

The clinical and demographic characteristics of the patients in the two groups were fairly well balanced at randomisation (Table 1), although those allocated to the intervention group tended to report more disability on the Roland disability questionnaire than did the control group. Most patients (118, 63%), when asked, would have preferred to be allocated to the exercise programme. Attendance of the classes was considered quite good, with 73% of the intervention group attending between six and eight of the classes. Four people failed to attend any classes and were included in the intention to treat analysis. No patients allocated to the control group took part in the exercise programme.

 

Table 1 Baseline Characteristics of Patients with Mechanical Low Back Pain Included in Study

Table 1: Baseline characteristics of patients with mechanical low back pain included in study. Values are means (standard deviations) unless stated otherwise.

 

Clinical Outcomes

 

Table ?2 shows the mean changes in outcome measures over time, from randomisation to final follow up at one year. After adjustment for baseline scores, the intervention group showed greater decreases in all measures of back pain and disability compared with the controls. At six weeks after randomisation, patients in the intervention group reported less distressing pain than the control group (P=0.03) and a marginally significant difference on the Roland disability questionnaire scores. Other variables were not significantly different, but the differences in change were all in favour of the intervention group. At six months the difference of the mean change scores of the Roland disability questionnaire was significant, and at one year the differences in changes of both the Roland disability questionnaire and the Aberdeen back pain scale were significant (Table ?2). Most of the intervention group improved by at least three points on the Roland disability questionnaire: 53% (95% confidence interval 42% to 64%) had done so at six weeks, 60% (49% to 71%) at six months, and 64% (54% to 74%) at one year. A smaller proportion of the control group achieved this clinically important improvement: 31% (22% to 40%) at six weeks, 40% (29% to 50%) at six months, and 35% (25% to 45%) at one year.

 

Table 2 Changes in Back Pain Scores from Baseline Values in Intervention and Control Groups

Table 2: Changes in back pain scores from baseline values in intervention and control groups at 6 weeks, 6 months, and 1 year follow up.

 

Patients� Preference

 

We examined the effect of patients� baseline preference for treatment on outcome after adjusting for baseline scores and main effects. Preference did not significantly affect response to treatment. The intervention had similar effects on both costs and outcomes regardless of baseline preference. For example, the change in the Roland disability questionnaire score at 12 months in the control group was ?1.93 for patients who preferred intervention and ?1.18 for those who were indifferent (95% confidence interval of difference ?1.05 to 2.55), and in the intervention group the change in score was ?3.10 for those who preferred intervention and ?3.15 for those who were indifferent ((95% confidence interval of difference ?1.47 to 3.08). As the interaction term (preference by random allocation) was non-significant, the results shown in Table ?2 exclude the preference term.

 

Economic Evaluation

 

Patients in the intervention group tended to use fewer healthcare and other resources compared with those in the control group (Table ?3). However, the mean difference, totalling �148 per patient, was not significant: the 95% confidence interval suggests there could have been a saving of as much as �442 per patient in the intervention group or an additional cost of up to �146. Patients in the control group took a total of 607 days off work during the 12 months after randomisation compared with 378 days taken off by the intervention group.

 

Table 3 Use of Services and their Costs Associated with Back Pain in the Two Study Groups

Table 3: Use of services and their costs associated with back pain in the two study groups at 12 months follow up.

 

Discussion

 

Our results support the hypothesis that a simple exercise class can lead to long term improvements for back pain sufferers. Studies have shown that a similar programme for patients with chronic back pain can be effective in the hospital setting. In this study we show the clinical effectiveness for patients with subacute or recurrent low back pain who were referred by their general practitioner to a community programme.

 

Current management guidelines for low back pain recommend a return to physical activity and taking exercise. In particular, they recommend that patients who are not improving at six weeks after onset of back pain, which may be a higher proportion than previously realised, should be referred to a reactivation programme. The programme we evaluated fits that requirement well. It shows participants how they can safely start moving again and increase their levels of physical activity. It is simple and less costly than individual treatment.

 

It seemed to have beneficial effects even one year later, as measured by functional disability (Roland disability questionnaire) and clinical status (Aberdeen back pain scale). The mean changes in scores on these instruments were small, with many patients reporting mild symptoms on the day of entry to the trial. However, a substantially larger proportion of participants in the exercise classes gained increases of over three points on the Roland disability questionnaire at six weeks, six months, and one year, which might be clinically important. At six weeks, participants in the exercise classes reported significantly less distressing pain compared with the control group, although the intensity of pain was not significantly different. This is consistent with findings from a study of chronic back pain patients in Oxford, in which changes in distressing pain were much greater than were the changes in intensity of pain.

 

People with back pain who use coping strategies that do not avoid movement and pain have less disability. In our study the participants in the exercise classes were able to function better according to Roland disability questionnaire scores than the control group at six months and one year after randomisation to treatment, and at one year they also showed a significantly greater improvement in clinical status as measured by the Aberdeen back pain scale. This increase in differences in effect between the intervention and control groups over time is consistent with the results from long term follow up in comparable back pain trials.

 

Study Design

 

The design of this study was a conventional randomised controlled trial in that all eligible patients were randomised. However, the participants were asked to state their preferred treatment before they knew of their allocation. A study of antenatal services showed that preferences can be an important determinant of outcome, but we did not find any strong effect of preference on the outcome, although a much larger sample size would be needed to confidently exclude any modest interaction between preference and outcome. This information may be useful to clinicians in that it suggests that exercise classes are effective even in patients who are not highly motivated. Our trial design, of asking patients for their preferences at the outset, has substantial advantages over the usual patient preference design, in which costs and outcomes cannot be reliably controlled for confounding by preference.

 

Conclusions

 

Our exercise programme did not seem to influence the intensity of pain but did affect the participants� ability to cope with the pain in the short term and even more so in the longer term. It used a cognitive-behavioural model, shifting the emphasis away from a disease model to a model of normal human behaviour, and with minimal extra training a physiotherapist can run it. Patients� preferences did not seem to influence the outcome.

 

Figure 1 Flow Chart Describing Patient Progress Through the Trial

Figure 1: Flow chart describing patients’ progress through the trial.

 

Footnotes

 

Funding: This research was funded by the Arthritis Research Campaign, the Northern and Yorkshire Regional Health Authority, and the National Back Pain Association.

 

Competing interests: None declared.

 

In conclusion,�the participation of patients in functional fitness and/or exercise as recommended by a physiotherapist, or physical therapist, or any other healthcare professional, such as a chiropractor, is essential towards the improvement of their symptoms of low back pain. The exercise programme helped patients better cope with their symptoms of back pain where the intervention group showed that they used fewer healthcare resources and took fewer day off work, according to the outcome measures of the research study. Information referenced from the National Center for Biotechnology Information (NCBI). The scope of our information is limited to chiropractic as well as to spinal injuries and conditions. To discuss the subject matter, please feel free to ask Dr. Jimenez or contact us at 915-850-0900 .

 

Curated by Dr. Alex Jimenez

 

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Additional Topics: Sciatica

 

Sciatica is referred to as a collection of symptoms rather than a single type of injury or condition. The symptoms are characterized as radiating pain, numbness and tingling sensations from the sciatic nerve in the lower back, down the buttocks and thighs and through one or both legs and into the feet. Sciatica is commonly the result of irritation, inflammation or compression of the largest nerve in the human body, generally due to a herniated disc or bone spur.

 

blog picture of cartoon paperboy big news

 

IMPORTANT TOPIC: EXTRA EXTRA: Treating Sciatica Pain

 

 

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Non-Invasive Treatment Modalities for Back Pain

Non-Invasive Treatment Modalities for Back Pain

Attributed from a personal perspective, as a practicing chiropractor with experience on a variety of spinal injuries and conditions, back pain is one of the most common health issues reported among the general population, affecting about 8 out of 10 individuals at some point throughout their lives. While many different types of treatments are currently available to help improve the symptoms of back pain, health care based on clinical and experimental evidence has caused an impact on the type of treatment individuals will receive for their back pain. Many patients in health care are turning to non-invasive treatment modalities for their back pain as a result of growing evidence associated with its safety and effectiveness.

 

On a further note, non-invasive treatment modalities are defined as conservative procedures which do not require incision into the body, where no break in the skin is created and there is no contact with the mucosa or internal body cavity beyond a natural or artificial body orifice, or the removal of tissue. The clinical and experimental methods and results of a variety of non-invasive treatment modalities on back pain have been described and discussed in detail below.

 

Abstract

 

At present, there is an increasing international trend towards evidence-based health care. The field of low back pain (LBP) research in primary care is an excellent example of evidence-based health care because there is a huge body of evidence from randomized trials. These trials have been summarized in a large number of systematic reviews. This paper summarizes the best available evidence from systematic reviews conducted within the framework of the Cochrane Back Review Group on non-invasive treatments for non-specific LBP. Data were gathered from the latest Cochrane Database of Systematic Reviews 2005, Issue 2. The Cochrane reviews were updated with additional trials, if available. Traditional NSAIDs, muscle relaxants, and advice to stay active are effective for short-term pain relief in acute LBP. Advice to stay active is also effective for long-term improvement of function in acute LBP. In chronic LBP, various interventions are effective for short-term pain relief, i.e. antidepressants, COX2 inhibitors, back schools, progressive relaxation, cognitive�respondent treatment, exercise therapy, and intensive multidisciplinary treatment. Several treatments are also effective for short-term improvement of function in chronic LBP, namely COX2 inhibitors, back schools, progressive relaxation, exercise therapy, and multidisciplinary treatment. There is no evidence that any of these interventions provides long-term effects on pain and function. Also, many trials showed methodological weaknesses, effects are compared to placebo, no treatment or waiting list controls, and effect sizes are small. Future trials should meet current quality standards and have adequate sample size.

 

Keywords: Non-specific low back pain, Non-invasive treatment, Primary care, Effectiveness, Evidence review

 

Introduction

 

Low back pain is most commonly treated in primary health care settings. Clinical management of acute as well as chronic low back pain (LBP) varies substantially among health care providers. Also, many different primary health care professionals are involved in the management of LBP, such as general practitioners, physical therapists, chiropractors, osteopaths, manual therapists, and others. There is a need to increase consistency in the management of LBP across professions.

 

At present, there is an increasing international trend towards evidence-based health care. Within the framework of evidence-based health care, clinicians should conscientiously, explicitly, and judiciously use the best current evidence in making decisions about the care of individual patients. The field of LBP research in primary care is an excellent example of evidence-based health care because there is a huge body of evidence. At present, more than 500 randomized controlled trials (RCTs) have been published, evaluating all types of conservative and alternative treatments for LBP that are commonly used in primary care. These trials have been summarized in a large number of systematic reviews. The Cochrane Back Review Group (CBRG) offers a framework for conducting and publishing systematic reviews in the fields of back and neck pain. However, method guidelines have also been developed and published by the CBRG to improve the quality of reviews in this field and to facilitate comparison across reviews and enhance consistency among reviewers. This paper summarizes the best available evidence from systematic reviews conducted within the framework of the CBRG on non-invasive treatments for non-specific LBP.

 

Objectives

 

To determine the effectiveness of non-invasive (pharmaceutical and non-pharmaceutical) interventions compared to placebo (or sham treatment, no intervention and waiting list control) or other interventions for acute, subacute, and chronic non-specific LBP. Trials comparing various types of the same interventions (e.g. various types of NSAIDs or various types of exercises) were excluded. The evidence on complementary and alternative medicine interventions (acupuncture, botanical medicines, massage, and neuroreflexotherapy) has been published elsewhere. Evidence on surgical and other invasive interventions for LBP will be presented in another paper in the same issue of the European Spine Journal.

 

Methods

 

The results of systematic reviews conducted within the framework of the CBRG were used. Most of these reviews were published, but preliminary results from one Cochrane review on patient education (A. Engers et al., submitted for publication) that has been submitted for publication were also used. Because no Cochrane review was available, we used two recently published systematic reviews for the evidence summary on antidepressants. The Cochrane review on work conditioning, work hardening, and functional restoration was not taken into account because all trials included in this review were also included in the reviews on exercise therapy and multidisciplinary treatment. The Cochrane reviews were updated with additional trials, if available, using Clinical Evidence as source (www.clinicalevidence.com). This manuscript consists of two parts: one on evidence of pharmaceutical interventions and the other on evidence of non-pharmaceutical interventions for non-specific LBP.

 

Search Strategy and Study Selection

 

The following search strategy was used in the Cochrane reviews:

 

  1. A computer aided search of the Medline and Embase databases since their beginning.
  2. A search of the Cochrane Central Register of Controlled Trials (Central).
  3. Screening references given in relevant systematic reviews and identified trials.
  4. Personal communication with content experts in the field.

 

Two reviewers independently applied the inclusion criteria to select the potentially relevant trials from the titles, abstracts, and keywords of the references retrieved by the literature search. Articles for which disagreement existed, and articles for which title, abstract, and keywords provided insufficient information for a decision on selection were obtained to assess whether they met the inclusion criteria. A consensus method was used to resolve disagreements between the two reviewers regarding the inclusion of studies. A third reviewer was consulted if disagreements were not resolved in the consensus meeting.

 

Inclusion Criteria

 

Study design. RCTs were included in all reviews.

 

Participants. Participants of trials that were included in the systematic reviews usually had acute (less than 6 weeks), subacute (6�12 weeks), and/or chronic (12 weeks or more) LBP. All reviews included patients with non-specific LBP.

 

Interventions. All reviews included one specific intervention. Typically any comparison group was allowed, but comparisons with no treatment/placebo/waiting list controls and other interventions were separately presented.

 

Outcomes. The outcome measures included in the systematic reviews were outcomes of symptoms (e.g. pain), overall improvement or satisfaction with treatment, function (e.g. back-specific functional status), well-being (e.g. quality of life), disability (e.g. activities of daily living, work absenteeism), and side effects. Results were separately presented for short-term and long-term follow-up.

 

Methodological Quality Assessment

 

In most reviews, the methodological quality of trials included in the reviews was assessed using the criteria recommended by the CBRG. The studies were not blinded for authors, institutions, or the journals in which the studies were published. The criteria were: (1) adequate allocation concealment, (2) adequate method of randomization, (3) similarity of baseline characteristics, (4) blinding of patients, (5) blinding of care provider, (6) equal co-interventions, (7) adequate compliance, (8) identical timing of outcome assessment, (9) blinded outcome assessment, (10) withdrawals and drop outs adequate, and (11) intention-to-treat analysis. All items were scored as positive, negative, or unclear. High quality was typically defined as fulfilling 6 or more of the 11 quality criteria. We refer readers to the original Cochrane reviews for details of the quality of trials.

 

Data Extraction

 

The data that were extracted and presented in tables included characteristics of participants, interventions, outcomes, and results. We refer readers to the original Cochrane reviews for summaries of trial data.

 

Data Analysis

 

Some reviews conducted a meta-analysis using statistical methods to analyse and summarize the data. If relevant valid data were lacking (data were too sparse or of inadequate quality) or if data were statistically too heterogeneous (and the heterogeneity could not be explained), statistical pooling was avoided. In these cases, reviewers performed a qualitative analysis. In the qualitative analyses, various levels of evidence were used that took into account the participants, interventions, outcomes, and methodological quality of the original studies. If only a subset of available trials provided sufficient data for inclusion in a meta-analysis (e.g. only some trials reported standard deviations), both a quantitative and qualitative analysis was used.

 

Dr. Alex Jimenez’s Insight

The purpose of the following research study was to determine which of the various non-invasive treatment modalities used could be safe and most effective towards the prevention, diagnosis and treatment of acute, subacute and chronic non-specific low back pain, as well as general back pain. All of the systematic reviews included participants with some type of non-specific low back pain, or LBP, where each received health care for one specific intervention. The outcome measures included in the systematic reviews were based on symptoms, overall improvement or satisfaction with treatment, function, well-being, disability and side effects. The data of the results was extracted and presented in Tables 1 and 2. The researchers of the study performed a qualitative analysis of all the presented clinical and experimental data before demonstrating it in this article. As a healthcare professional, or patient with back pain, the information in this research study may help determine which non-invasive treatment modality should be considered to achieve the desired recovery outcome measures.

 

Results

 

Pharmaceutical Interventions

 

Antidepressants

 

There are three reasons for using antidepressants in the treatment of LBP. The first reason is that chronic LBP patients often also cope with depression, and treatment with antidepressants may elevate mood and increase pain tolerance. Second, many antidepressant drugs are sedating, and it has been suggested that part of their value for managing chronic pain syndromes simply could be improving sleep. The third reason for the use of antidepressants in chronic LBP patients is their supposed analgesic action, which occurs at lower doses than the antidepressant effect.

 

Effectiveness of antidepressants for acute LBP No trials were identified.

 

Effectiveness of antidepressants for chronic LBP Antidepressants versus placebo. We found two systematic reviews including a total of nine trials. One review found that antidepressants significantly increased pain relief compared with placebo but found no significant difference in functioning [pain: standardized mean difference (SMD) 0.41, 95% CI 0.22�0.61; function: SMD 0.24, 95% CI -0.21 to +0.69]. The other review did not statistically pool data but had similar results.

 

Adverse effects Adverse effects of antidepressants include dry mouth, drowsiness, constipation, urinary retention, orthostatic hypotension, and mania. One RCT found that the prevalence of dry mouth, insomnia, sedation, and orthostatic symptoms was 60�80% with tricyclic antidepressants. However, rates were only slightly lower in the placebo group and none of the differences were significant. In many trials, the reporting of side effects was insufficient.

 

Muscle Relaxants

 

The term �muscle relaxants� is very broad and includes a wide range of drugs with different indications and mechanisms of action. Muscle relaxants can be divided into two main categories: antispasmodic and antispasticity medications.

 

Antispasmodics are used to decrease muscle spasm associated with painful conditions such as LBP. Antispasmodics can be subclassified into benzodiazepines and non-benzodiazepines. Benzodiazepines (e.g. diazepam, tetrazepam) are used as anxiolytics, sedatives, hypnotics, anticonvulsants, and/or skeletal muscle relaxants. Non-benzodiazepines include a variety of drugs that can act at the brain stem or spinal cord level. The mechanisms of action with the central nervous system are still not completely understood.

 

Antispasticity medications are used to reduce spasticity that interferes with therapy or function, such as in cerebral palsy, multiple sclerosis, and spinal cord injuries. The mechanism of action of the antispasticity drugs with the peripheral nervous system (e.g. dantrolene sodium) is the blockade of the sarcoplasmic reticulum calcium channel. This reduces calcium concentration and diminishes actin�myosin interaction.

 

Effectiveness of muscle relaxants for acute LBP Benzodiazepines versus placebo. One study showed that there is limited evidence (one trial; 50 people) that an intramuscular injection of diazepam followed by oral diazepam for 5 days is more effective than placebo for patients with acute LBP on short-term pain relief and better overall improvement, but is associated with substantially more central nervous system side effects.

 

Non-benzodiazepines versus placebo. Eight studies were identified. One high quality study on acute LBP showed that there is moderate evidence (one trial; 80 people) that a single intravenous injection of 60 mg orphenadrine is more effective than placebo in immediate relief of pain and muscle spasm for patients with acute LBP.

 

Three high quality and one low quality trial showed that there is strong evidence (four trials; 294 people) that oral non-benzodiazepines are more effective than placebo for patients with acute LBP on short-term pain relief, global efficacy, and improvement of physical outcomes. The pooled RR and 95% CIs for pain intensity was 0.80 (0.71�0.89) after 2�4 days (four trials; 294 people) and 0.58 (0.45�0.76) after 5�7 days follow-up (three trials; 244 people). The pooled RR and 95% CIs for global efficacy was 0.49 (0.25�0.95) after 2�4 days (four trials; 222 people) and 0.68 (0.41�1.13) after 5�7 days follow-up (four trials; 323 people).

 

Antispasticity drugs versus placebo. Two high quality trials showed that there is strong evidence (two trials; 220 people) that antispasticity muscle relaxants are more effective than placebo for patients with acute LBP on short-term pain relief and reduction of muscle spasm after 4 days. One high quality trial also showed moderate evidence on short-term pain relief, reduction of muscle spasm, and overall improvement after 10 days.

 

Effectiveness of muscle relaxants for chronic LBP Benzodiazepines versus placebo. Three studies were identified. Two high quality trials on chronic LBP showed that there is strong evidence (two trials; 222 people) that tetrazepam 50 mg t.i.d. is more effective than placebo for patients with chronic LBP on short-term pain relief and overall improvement. The pooled RRs and 95% CIs for pain intensity were 0.82 (0.72�0.94) after 5�7 days follow-up and 0.71 (0.54�0.93) after 10�14 days. The pooled RR and 95% CI for overall improvement was 0.63 (0.42�0.97) after 10�14 days follow-up. One high quality trial showed that there is moderate evidence (one trial; 50 people) that tetrazepam is more effective than placebo on short-term decrease of muscle spasm.

 

Non-benzodiazepines versus placebo. Three studies were identified. One high quality trial showed that there is moderate evidence (one trial; 107 people) that flupirtin is more effective than placebo for patients with chronic LBP on short-term pain relief and overall improvement after 7 days, but not on reduction of muscle spasm. One high quality trial showed that there is moderate evidence (one trial; 112 people) that tolperisone is more effective than placebo for patients with chronic LBP on short-term overall improvement after 21 days, but not on pain relief and reduction of muscle spasm.

 

Adverse effects Strong evidence from all eight trials on acute LBP (724 people) showed that muscle relaxants are associated with more total adverse effects and central nervous system adverse effects than placebo, but not with more gastrointestinal adverse effects; RRs and 95% CIs were 1.50 (1.14�1.98), 2.04 (1.23�3.37), and 0.95 (0.29�3.19), respectively. The most commonly and consistently reported adverse events involving the central nervous system were drowsiness and dizziness. For the gastrointestinal tract this was nausea. The incidence of other adverse events associated with muscle relaxants was negligible.

 

NSAIDs

 

The rationale for the treatment of LBP with NSAIDs is based both on their analgesic potential and their anti-inflammatory action.

 

Effectiveness of NSAIDs for acute LBP NSAIDs versus placebo. Nine studies were identified. Two studies reported on LBP without radiation, two on sciatica, and the other five on a mixed population. There was conflicting evidence that NSAIDs provide better pain relief than placebo in acute LBP. Six of the nine studies which compared NSAIDs with placebo for acute LBP reported dichotomous data on global improvement. The pooled RR for global improvement after 1 week using the fixed effects model was 1.24 (95% CI 1.10�1.41), indicating a statistically significant effect in favour of NSAIDs compared to placebo. The pooled RR (three trials) for analgesic use using the fixed effects model was 1.29 (95% CI 1.05�1.57), indicating significantly less use of analgesics in the NSAIDs group.

 

NSAIDs versus paracetamol/acetaminophen. There were no differences between NSAIDs and paracetamol reported in two studies, but one study reported better outcomes for two of the four types of NSAIDs. There is conflicting evidence that NSAIDs are more effective than paracetamol for acute LBP.

 

NSAIDs versus other drugs. Six studies reported on acute LBP, of which five did not find any differences between NSAIDs and narcotic analgesics or muscle relaxants. Group sizes in these studies ranged from 19 to 44 and, therefore, these studies simply may have lacked power to detect a statistically significant difference. There is moderate evidence that NSAIDs are not more effective than other drugs for acute LBP.

 

Effectiveness of NSAIDs for chronic LBP NSAIDs versus placebo. One small cross-over study (n=37) found that naproxen sodium 275 mg capsules (two capsules b.i.d.) decreased pain more than placebo at 14 days.

 

COX2 inhibitors versus placebo. Four additional trials were identified. There is strong evidence that COX2 inhibitors (etoricoxib, rofecoxib and valdecoxib) decreased pain and improved function compared with placebo at 4 and 12 weeks, but effects were small.

 

Adverse effects NSAIDs may cause gastrointestinal complications. Seven of the nine studies which compared NSAIDs with placebo for acute LBP reported data on side effects. The pooled RR for side effects using the fixed effects model was 0.83 (95% CI 0.64�1.08), indicating no statistically significant difference. One systematic review of the harms of NSAIDs found that ibuprofen and diclofenac had the lowest gastrointestinal complication rate, mainly because of the low doses used in practice (pooled OR for adverse effects vs. placebo 1.30, 95% CI 0.91�1.80). COX2 inhibitors have been shown to have less gastrointestinal side effects in osteoarthritis and rheumatoid arthritis studies. However, increased cardiovascular risk (myocardial infarction and stroke) has been reported with long-term use.

 

Non-Pharmaceutical Interventions

 

Advice to Stay Active

 

Effectiveness of advice to stay active for acute LBP Stay active versus bed rest. The Cochrane review found four studies that compared advice to stay active as single treatment with bed rest. One high quality study showed that advice to stay active significantly improved functional status and reduced sick leave after 3 weeks compared with advice to rest in bed for 2 days. It also found a significant reduction of pain intensity in favour of the stay active group at intermediate follow-up (more than 3 weeks). The low quality studies showed conflicting results. The additional trial (278 people) found no significant differences in pain intensity and functional disability between advice to stay active and bed rest after 1 month. However, it found that advice to stay active significantly reduced sick leave compared with bed rest up to day 5 (52% with advice to stay active vs. 86% with bed rest; P<0.0001).

 

Stay active versus exercise. One trial found short-term improvement in functional status and reduction in sick leave in favour of advice to stay active. A significant reduction in sick leave in favour of the stay active group was also reported at long-term follow-up.

 

Effectiveness of advice to stay active for chronic LBP No trials identified.

 

Adverse effects No trials reported side effects.

 

Back Schools

 

The original �Swedish back school� was introduced by Zachrisson Forsell in 1969. It was intended to reduce the pain and prevent recurrences. The Swedish back school consisted of information on the anatomy of the back, biomechanics, optimal posture, ergonomics, and back exercises. Four small group sessions were scheduled during a 2-week period, with each session lasting 45 min. The content and length of back schools has changed and appears to vary widely today.

 

Effectiveness of back schools for acute LBP Back schools versus waiting list controls or �placebo� interventions. Only one trial compared back school with placebo (shortwaves at the lowest intensity) and showed better short-term recovery and return to work for the back school group. No other short- or long-term differences were found.

 

Back schools versus other interventions. Four studies (1,418 patients) showed conflicting evidence on the effectiveness of back schools compared to other treatments for acute and subacute LBP on pain, functional status, recovery, recurrences, and return to work (short-, intermediate-, and long-term follow-up).

 

Effectiveness of back schools for chronic LBP Back schools versus waiting list controls or �placebo� interventions. There is conflicting evidence (eight trials; 826 patients) on the effectiveness of back schools compared to waiting list controls or placebo interventions on pain, functional status, and return to work (short-, intermediate-, and long-term follow-up) for patients with chronic LBP.

 

Back schools versus other treatments. Six studies were identified comparing back schools with exercises, spinal or joint manipulation, myofascial therapy, and some kind of instructions or advice. There is moderate evidence (five trials; 1,095 patients) that a back school is more effective than other treatments for patients with chronic LBP for pain and functional status (short- and intermediate-term follow-up). There is moderate evidence (three trials; 822 patients) that there is no difference in long-term pain and functional status.

 

Adverse effects None of the trials reported any adverse effects.

 

Bed Rest

 

One rationale for bed rest is that many patients experience relief of symptoms in a horizontal position.

 

Effectiveness of bed rest for acute LBP Twelve trials were included in the Cochrane review. Some trials were on a mixed population of patients with acute and chronic LBP or on a population of patients with sciatica.

 

Bed rest versus advice to stay active. Three trials (481 patients) were included in this comparison. The results of two high quality trials showed small but consistent and significant differences in favour of staying active, at 3- to 4-week follow-up [pain: SMD 0.22 (95% CI 0.02�0.41); function: SMD 0.31 (95% CI 0.06�0.55)], and at 12-week follow-up [pain: SMD 0.25 (95% CI 0.05�0.45); function: SMD 0.25 (95% CI 0.02�0.48)]. Both studies also reported significant differences in sick leave in favour of staying active. There is strong evidence that advice to rest in bed is less effective than advice to stay active for reducing pain and improving functional status and speeding-up return to work.

 

Bed rest versus other interventions. Three trials were included. Two trials compared advice to rest in bed with exercises and found strong evidence that there was no difference in pain, functional status, or sick leave at short- and long-term follow-up. One study found no difference in improvement on a combined pain, disability, and physical examination score between bed rest and manipulation, drug therapy, physiotherapy, back school, or placebo.

 

Short bed rest versus longer bed rest. One trial in patients with sciatica reported no significant difference in pain intensity between 3 and 7 days of bed rest, measured 2 days after the end of treatment.

 

Effectiveness of bed rest for chronic LBP There were no trials identified.

 

Adverse effects No trials reported adverse effects.

 

Behavioural Treatment

 

The treatment of chronic LBP not only focuses on removing the underlying organic pathology, but also tries to reduce disability through the modification of environmental contingencies and cognitive processes. In general, three behavioural treatment approaches can be distinguished: operant, cognitive, and respondent. Each of these approaches focus on the modification of one of the three response systems that characterize emotional experiences: behaviour, cognition, and physiological reactivity.

 

Operant treatments include positive reinforcement of healthy behaviours and consequent withdrawal of attention towards pain behaviours, time-contingent instead of pain-contingent pain management, and spousal involvement. The operant treatment principles can be applied by all health care disciplines involved with the patient.

 

Cognitive treatment aims to identify and modify patients� cognitions regarding their pain and disability. Cognition (the meaning of pain, expectations regarding control over pain) can be modified directly by cognitive restructuring techniques (such as imagery and attention diversion), or indirectly by the modification of maladaptive thoughts, feelings, and beliefs.

 

Respondent treatment aims to modify the physiological response system directly, e.g. by reduction of muscular tension. Respondent treatment includes providing the patient with a model of the relationship between tension and pain, and teaching the patient to replace muscular tension by a tension-incompatible reaction, such as the relaxation response. Electromyographic (EMG) biofeedback, progressive relaxation, and applied relaxation are frequently used.

 

Behavioural techniques are often applied together as part of a comprehensive treatment approach. This so-called cognitive�behavioural treatment is based on a multidimensional model of pain that includes physical, affective, cognitive, and behavioural components. A large variety of behavioural treatment modalities are used for chronic LBP because there is no general consensus about the definition of operant and cognitive methods. Furthermore, behavioural treatment often consists of a combination of these modalities or is applied in combination with other therapies (such as medication or exercises).

 

Effectiveness of behavioural therapy for acute LBP One RCT (107 people) identified by the review found that cognitive�behavioural therapy reduced pain and perceived disability after 9�12 months compared with traditional care (analgesics plus back exercises until pain had subsided).

 

Effectiveness of behavioural therapy for chronic LBP Behavioural treatment versus waiting list controls. There is moderate evidence from two small trials (total of 39 people) that progressive relaxation has a large positive effect on pain (1.16; 95% CI 0.47�1.85) and behavioural outcomes (1.31; 95% CI 0.61�2.01) in the short-term. There is limited evidence that progressive relaxation has a positive effect on short-term back-specific and generic functional status.

 

There is moderate evidence from three small trials (total of 88 people) that there is no significant difference between EMG biofeedback and waiting list control on behavioural outcomes in the short-term. There is conflicting evidence (two trials; 60 people) on the effectiveness of EMG versus waiting list control on general functional status.

 

There is conflicting evidence from three small trials (total of 153 people) regarding the effect of operant therapy on short-term pain intensity, and moderate evidence that there is no difference [0.35 (95% CI -0.25 to 0.94)] between operant therapy and waiting list control for short-term behavioural outcomes. Five studies compared combined respondent and cognitive therapy with waiting list controls. There is strong evidence from four small trials (total of 134 people) that combined respondent and cognitive therapy has a medium sized, short-term positive effect on pain intensity. There is strong evidence that there are no differences [0.44 (95% CI -0.13 to 1.01)] on short-term behavioural outcomes.

 

Behavioural treatment versus other interventions. There is limited evidence (one trial; 39 people) that there are no significant differences between behavioural treatment and exercise on pain intensity, generic functional status and behavioural outcomes, either post-treatment, or at 6- or 12-month follow-up.

 

Adverse effects None reported in the trials.

 

Exercise Therapy

 

Exercise therapy is a management strategy that is widely used in LBP; it encompasses a heterogeneous group of interventions ranging from general physical fitness or aerobic exercise, to muscle strengthening, to various types of flexibility and stretching exercises.

 

Effectiveness of exercise therapy for acute LBP Exercise versus no treatment. The pooled analysis failed to show a difference in short-term pain relief between exercise therapy and no treatment, with an effect of -0.59 points/100 (95% CI -12.69 to 11.51).

 

Exercise versus other interventions. Of 11 trials involving 1,192 adults with acute LBP, 10 had non-exercise comparisons. These trials provide conflicting evidence. The pooled analysis showed that there was no difference at the earliest follow-up in pain relief when compared to other conservative treatments: 0.31 points (95% CI -0.10 to 0.72). Similarly, there was no significant positive effect of exercise on functional outcomes. Outcomes show similar trends at short-, intermediate-, and long-term follow-up.

 

Effectiveness of exercise therapy for subacute LBP Exercise versus other interventions. Six studies involving 881 subjects had non-exercise comparisons. Two trials found moderate evidence of reduced work absenteeism with a graded activity intervention compared to usual care. The evidence is conflicting regarding the effectiveness of other exercise therapy types in subacute LBP compared to other treatments.

 

Effectiveness of exercise therapy for chronic LBP Exercise versus other interventions. Thirty-three exercise groups in 25 trials on chronic LBP had non-exercise comparisons. These trials provide strong evidence that exercise therapy is at least as effective as other conservative interventions for chronic LBP. Two exercise groups in high quality studies and nine groups in low quality studies found exercise more effective than comparison treatments. These studies, mostly conducted in health care settings, commonly used exercise programs that were individually designed and delivered (as opposed to independent home exercises). The exercise programs commonly included strengthening or trunk stabilizing exercises. Conservative care in addition to exercise therapy was often included in these effective interventions, including behavioural and manual therapy, advice to stay active, and education. One low quality trial found a group-delivered aerobics and strengthening exercise program resulted in less improvement in pain and function outcomes than behavioural therapy. Of the remaining trials, 14 (2 high quality and 12 low quality) found no statistically significant or clinically important differences between exercise therapy and other conservative treatments; 4 of these trials were inadequately powered to detect clinically important differences on at least one outcome. Trials were rated low quality most commonly because of inadequate assessor blinding.

 

Meta-analysis of pain outcomes at the earliest follow-up included 23 exercise groups with an independent comparison and adequate data. Synthesis resulted in a pooled weighted mean improvement of 10.2 points (95% CI 1.31�19.09) for exercise therapy compared to no treatment, and 5.93 points (95% CI 2.21�9.65) compared to other conservative treatment [vs. all comparisons 7.29 points (95% CI 3.67�0.91)]. Smaller improvements were seen in functional outcomes with an observed mean positive effect of 3.15 points (95% CI -0.29 to 6.60) compared to no treatment, and 2.37 points (95% CI 0.74�4.0) versus other conservative treatment at the earliest follow-up [vs. all comparisons 2.53 points (95% CI 1.08�3.97)].

 

Adverse effects Most trials did not report any side effects. Two studies reported cardiovascular events that were considered not to be caused by the exercise therapy.

 

Lumbar Supports

 

Lumbar supports are provided as treatment to people suffering from LBP with the aim of making the impairment and disability vanish or decrease. Different desired functions have been suggested for lumbar supports: (1) to correct deformity, (2) to limit spinal motion, (3) to stabilize part of the spine, (4) to reduce mechanical uploading, and (5) miscellaneous effects: massage, heat, placebo. However, at the present time the putative mechanisms of action of a lumbar support remain a matter of debate.

 

Effectiveness of lumbar supports for acute LBP No trials were identified.

 

Effectiveness of lumbar supports for chronic LBP No RCT compared lumbar supports with placebo, no treatment, or other treatments for chronic LBP.

 

Effectiveness of lumbar supports for a mixed population of acute, subacute, and chronic LBP Four studies included a mix of patients with acute, subacute, and chronic LBP. One study did not give any information about the duration of the LBP complaints of the patients. There is moderate evidence that a lumbar support is not more effective in reducing pain than other types of treatment. Evidence on overall improvement and return to work was conflicting.

 

Adverse effects Potential adverse effects associated with prolonged lumbar support use include decreased strength of the trunk musculature, a false sense of security, heat, skin irritation, skin lesions, gastrointestinal disorders and muscle wasting, higher blood pressure and higher heart rates, and general discomfort.

 

Multidisciplinary Treatment Programmes

 

Multidisciplinary treatments for back pain evolved from pain clinics. Initially, multidisciplinary treatments focused on a traditional biomedical model and in the reduction of pain. Current multidisciplinary approaches to chronic pain are based on a multifactorial biopsychosicial model of interrelating physical, psychological, and social/occupational factors. The content of multidisciplinary programs varies widely and, at present, it is unclear what the optimal content is and who should be involved.

 

Effectiveness of multidisciplinary treatment for subacute LBP No trials identified.

 

Effectiveness of multidisciplinary treatment for subacute LBP Multidisciplinary treatment versus usual care. Two RCTs on subacute LBP were included. The study population in both studies consisted of workers on sick leave. In one study the patients in the intervention group returned to work sooner (10 weeks) compared with the control group (15 weeks) (P=0.03). The intervention group also had fewer sick leave during follow-up than the control group (mean difference=-7.5 days, 95% CI -15.06 to 0.06). There was no statistically significant difference in pain intensity between the intervention and control group, but subjective disability had decreased significantly more in the intervention group than in the control group (mean difference=-1.2, 95% CI -1.984 to -0.416). In the other study, the median duration of absence from regular work was 60 days for the group with a combination of occupational and clinical intervention, 67 days with the occupational intervention group, 131 days with the clinical intervention group, and 120.5 days with the usual care group (P=0.04). Return to work was 2.4 times faster in the group with both an occupational and clinical intervention (95% CI 1.19�4.89) than the usual care group, and 1.91 times faster in the two groups with occupational intervention than the two groups without occupational interventions (95% CI 1.18�3.1). There is moderate evidence that multidisciplinary treatment with a workplace visit and comprehensive occupational health care intervention is effective with regard to return to work, sick leave, and subjective disability for patients with subacute LBP.

 

Effectiveness of multidisciplinary treatment for chronic LBP Multidisciplinary treatment versus other interventions. Ten RCTs with a total of 1,964 subjects were included in the Cochrane review. Three additional papers reported on long-term outcomes of two of these trials. All ten trials excluded patients with significant radiculopathy or other indication for surgery. There is strong evidence that intensive multidisciplinary treatment with a functional restoration approach improves function when compared with inpatient or outpatient non-multidisciplinary treatments. There is moderate evidence that intensive multidisciplinary treatment with a functional restoration approach reduces pain when compared with outpatient non-multidisciplinary rehabilitation or usual care. There is contradictory evidence regarding vocational outcomes. Five trials evaluating less intensive multidisciplinary treatment programmes could not demonstrate beneficial effects on pain, function, or vocational outcomes when compared with non-multidisciplinary outpatient treatment or usual care. One additional RCT was found that showed no difference between multidisciplinary treatment and usual care on function and health related quality of life after 2 and 6 months.

 

The reviewed studies provide evidence that intensive (>100 h of therapy) MBPSR with a functional restoration approach produces greater improvements in pain and function for patients with disabling chronic LBP than non-multidisciplinary rehabilitation or usual care. Less intensive treatments did not seem effective.

 

Adverse effects No adverse effects were reported.

 

Spinal Manipulation

 

Spinal manipulation is defined as a form of manual therapy which involves movement of a joint past its usual end range of motion, but not past its anatomic range of motion. Spinal manipulation is usually considered as that of long lever, low velocity, non-specific type manipulation as opposed to short lever, high velocity, specific adjustment. Potential hypotheses for the working mechanism of spinal manipulation are: (1) release for the entrapped synovial folds, (2) relaxation of hypertonic muscle, (3) disruption of articular or periarticular adhesion, (4) unbuckling of motion segments that have undergone disproportionate displacement, (5) reduction of disc bulge, (6) repositioning of miniscule structures within the articular surface, (7) mechanical stimulation of nociceptive joint fibres, (8) change in neurophysiological function, and (9) reduction of muscle spasm.

 

Effectiveness of spinal manipulation for acute LBP Spinal manipulation versus sham. Two trials were identified. Patients receiving treatment that included spinal manipulation had statistically significant and clinically important short-term improvements in pain (10-mm difference; 95% CI 2�17 mm) compared with sham therapy. However, the improvement in function was considered clinically relevant but not statistically significant (2.8-mm difference on the Roland Morris scale; 95% CI -0.1 to 5.6).

 

Spinal manipulation versus other therapies. Twelve trials were identified. Spinal manipulation resulted in statistically significant more short-term pain relief compared with other therapies judged to be ineffective or possibly even harmful (4-mm difference; 95% CI 1�8 mm). However, the clinical significance of this finding is questionable. The point estimate of improvement in short-term function for treatment with spinal manipulation compared with the ineffective therapies was considered clinically significant but was not statistically significant (2.1-point difference on the Roland Morris scale; 95% CI -0.2 to 4.4). There were no differences in effectiveness between patients treated with spinal manipulation and those treated with any of the conventionally advocated therapies.

 

Effectiveness of spinal manipulation for chronic LBP Spinal manipulation versus sham. Three trials were identified. Spinal manipulation was statistically significantly more effective compared with sham manipulation on short-term pain relief (10 mm; 95% CI 3�17 mm) and long-term pain relief (19 mm; 95% CI 3�35 mm). Spinal manipulation was also statistically significantly more effective on short-term improvement of function (3.3 points on the Roland and Morris Disability Questionnaire (RMDQ); 95% CI 0.6�6.0).

 

Spinal manipulation versus other therapies. Eight trials were identified. Spinal manipulation was statistically significantly more effective compared with the group of therapies judged to be ineffective or perhaps harmful on short-term pain relief (4 mm; 95% CI 0�8), and short-term improvement in function (2.6 points on the RMDQ; 95% CI 0.5�4.8). There were no differences in short- and long-term effectiveness compared with other conventionally advocated therapies such as general practice care, physical or exercise therapy, and back school.

 

Adverse effects In the RCTs identified by the review that used a trained therapist to select people and perform spinal manipulation, the risk of serious complications was low. An estimate of the risk of spinal manipulation causing a clinically worsened disk herniation or cauda equina syndrome in a patient presenting with lumbar disk herniation is calculated from published data to be less than 1 in 3.7 million.

 

Traction

 

Lumbar traction uses a harness (with velcro strapping) that is put around the lower rib cage and around the iliacal crest. Duration and level of force exerted through this harness can be varied in a continuous or intermittent mode. Only in motorized and bed rest traction can the force be standardized. With other techniques total body weight and the strength of the patient or therapist determine the forces exerted. In the application of traction force, consideration must be given to counterforces such as lumbar muscle tension, lumbar skin stretch and abdominal pressure, which depend on the patient�s physical constitution. If the patient is lying on the traction table, the friction of the body on the table provides the main counterforce during traction. The exact mechanism through which traction might be effective is unclear. It has been suggested that spinal elongation, through decreasing lordosis and increasing intervertebral space, inhibits nociceptive impulses, improves mobility, decreases mechanical stress, reduces muscle spasm or spinal nerve root compression (due to osteophytes), releases luxation of a disc or capsule from the zygo-apophysial joint, and releases adhesions around the zygo-apophysial joint and the annulus fibrosus. So far, the proposed mechanisms have not been supported by sufficient empirical information.

 

Thirteen of the studies identified in the Cochrane review included a homogeneous population of LBP patients with radiating symptoms. The remaining studies included a mix of patients with and without radiation. There were no studies exclusively involving patients who had no radiating symptoms.

 

Five studies included solely or primarily patients with chronic LBP of more than 12 weeks; in one study patients were all in the subacute range (4�12 weeks). In 11 studies the duration of LBP was a mixture of acute, subacute, and chronic. In four studies duration was not specified.

 

Effectiveness of traction for acute LBP No RCTs included primarily people with acute LBP. One study was identified that included patients with subacute LBP, but this population consisted of a mix of patients with and without radiation.

 

Effectiveness of traction for chronic LBP One trial found that continuous traction is not more effective on pain, function, overall improvement, or work absenteeism than placebo. One RCT (42 people) found no difference in effectiveness between standard physical therapy including continuous traction and the same program without traction. One RCT (152 people) found no significant difference between lumbar traction plus massage and interferential treatment in pain relief, or improvement of disability 3 weeks and 4 months after the end of treatment. This RCT did not exclude people with sciatica, but no further details of the proportion of people with sciatica were reported. One RCT (44 people) found that autotraction is more effective than mechanical traction on global improvement, but not on pain and function, in chronic LBP patients with or without radiating symptoms. However, this trial had several methodological problems that may be associated with biased results.

 

Adverse effects Little is known about the adverse effects of traction. Only a few case reports are available, which suggest that there is some danger for nerve impingement in heavy traction, i.e. lumbar traction forces exceeding 50% of the total body weight. Other risks described for lumbar traction are respiratory constraints due to the traction harness or increased blood pressure during inverted positional traction. Other potential adverse effects of traction include debilitation, loss of muscle tone, bone demineralization, and thrombophlebitis.

 

Transcutaneous Electrical Nerve Stimulation

 

Transcutaneous electrical nerve stimulation (TENS) is a therapeutic non-invasive modality mainly used for pain relief by electrically stimulating peripheral nerves via skin surface electrodes. Several types of TENS applications, differing in intensity and electrical characteristics, are used in clinical practice: (1) high frequency, (2) low frequency, (3) burst frequency, and (4) hyperstimulation.

 

Effectiveness of TENS for acute LBP: No trials were identified.

 

Effectiveness of TENS for chronic LBP The Cochrane review included two RCTs of TENS for chronic LBP. The results of one small trial (N=30) showed a significant decrease in subjective pain intensity with active TENS treatment compared to placebo over the course of the 60-min treatment session. The pain reduction seen at the end of stimulation was maintained for the entire 60-min post-treatment time interval assessed (data not shown). Longer term follow-up was not conducted in this study. The second trial (N=145) demonstrated no significant difference between active TENS and placebo for any of the outcomes measured, including pain, functional status, range of motion, and use of medical services.

 

Adverse effects In a third of the participants in one trial, minor skin irritation occurred at the site of electrode placement. These adverse effects were observed equally in the active TENS and placebo groups. One participant randomized to placebo TENS developed severe dermatitis 4 days after beginning therapy and was required to withdraw (Tables 1, ?2).

 

Table 1 Effectiveness of Conservative Interventions for Acute Non Specific Low Back Pain

Table 1: Effectiveness of conservative interventions for acute non-specific low back pain.

 

Table 2 Effectiveness of Conservative Interventions for Chronic Non Specific Low Back Pain

Table 2: Effectiveness of conservative interventions for chronic non-specific low back pain.

 

Discussion

 

The best available evidence for conservative treatments for non-specific LBP summarized in this paper shows that some interventions are effective. Traditional NSAIDs, muscle relaxants, and advice to stay active are effective for short-term pain relief in acute LBP. Advice to stay active is also effective for long-term improvement of function in acute LBP. In chronic LBP, various interventions are effective for short-term pain relief, i.e. antidepressants, COX2 inhibitors, back schools, progressive relaxation, cognitive�respondent treatment, exercise therapy, and intensive multidisciplinary treatment. Several treatments are also effective for short-term improvement of function in chronic LBP, namely COX2 inhibitors, back schools, progressive relaxation, exercise therapy, and multidisciplinary treatment. There is no evidence that any of these interventions provides long-term effects on pain and function. Also, many trials showed methodological weaknesses, effects are compared to placebo, no treatment or waiting list controls, and effect sizes are small. Future trials should meet current quality standards and have adequate sample size. However, in summary, there is evidence that some interventions are effective while evidence for many other interventions is lacking or there is evidence that they are not effective.

 

During the last decade, various clinical guidelines on the management of acute LBP in primary care have been published that have used this evidence. At present, guidelines exist in at least 12 different countries: Australia, Denmark, Finland, Germany, Israel, the Netherlands, New Zealand, Norway, Sweden, Switzerland, the United Kingdom, and the United States. Since the available evidence is international, one would expect that each country�s guidelines would give more or less similar recommendations regarding diagnosis and treatment. Comparison of clinical guidelines for the management of LBP in primary care from 11 different countries showed that the content of the guidelines regarding therapeutic interventions is quite similar. However, there were also some discrepancies in recommendations across guidelines. Differences in recommendations between guidelines may be due to incompleteness of the evidence, different levels of evidence, magnitude of effects, side effects and costs, differences in health care systems (organization/financial), or differences in membership of guidelines committees. More recent guidelines may have included more recently published trials and, therefore, may end up with slightly different recommendations. Also, guidelines may have been based on systematic reviews that included trials in different languages; the majority of existing reviews have considered only studies published in a few languages, and several, only those published in English. Recommendations in guidelines are not only based on scientific evidence, but also on consensus. Guideline committees may consider various arguments differently, such as the magnitude of the effects, potential side effects, cost-effectiveness, and current routine practice and available resources in their country. Especially as we know that effects in the field of LBP, if any, are usually small and short-term effects only, interpretation of effects may vary among guideline committees. Also, guideline committees may differently weigh other aspects such as side effects and costs. The constitution of the guideline committees and the professional bodies they represent may introduce bias�either for or against a particular treatment. This does not necessarily mean that one guideline is better than the other or that one is right and the other is wrong. It merely shows that when translating the evidence into clinically relevant recommendations more aspects play a role, and that these aspects may vary locally or nationally.

 

Recently European guidelines for the management of LBP were developed to increase consistency in the management of non-specific LBP across countries in Europe. The European Commission has approved and funded this project called �COST B13�. The main objectives of this COST action were developing European guidelines for the prevention, diagnosis and treatment of non-specific LBP, ensuring an evidence-based approach through the use of systematic reviews and existing clinical guidelines, enabling a multidisciplinary approach, and stimulating collaboration between primary health care providers and promoting consistency across providers and countries in Europe. Representatives from 13 countries participated in this project that was conducted between 1999 and 2004. The experts represented all relevant health professions in the field of LBP: anatomy, anaesthesiology, chiropractic, epidemiology, ergonomy, general practice, occupational care, orthopaedic surgery, pathology, physiology, physiotherapy, psychology, public health care, rehabilitation, and rheumatology. Within this COST B13 project four European guidelines were developed on: (1) acute LBP, (2) chronic LBP, (3) prevention of LBP, and (4) pelvic girdle pain. The guidelines will soon be published as a supplement to the European Spine Journal.

 

Contributor Information

 

Maurits W. van Tulder, Bart Koes, Antti Malmivaara: Ncbi.nlm.nih.gov

 

In conclusion,�the clinical and experimental evidence above for non-invasive treatment modalities on back pain demonstrated that several of the treatments are safe and effective. While the results of a variety of the methods used to improve back pain symptoms were proven to be efficient, many other treatment modalities requires additional evidence and others were reported to not be effective towards improving symptoms of back pain.�The main objective of the research study was to determine the safest and most effective guideline for the prevention, diagnosis and treatment of non-specific back pain.�Information referenced from the National Center for Biotechnology Information (NCBI). The scope of our information is limited to chiropractic as well as to spinal injuries and conditions. To discuss the subject matter, please feel free to ask Dr. Jimenez or contact us at 915-850-0900 .

 

Curated by Dr. Alex Jimenez

 

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Additional Topics: Sciatica

 

Sciatica is referred to as a collection of symptoms rather than a single type of injury or condition. The symptoms are characterized as radiating pain, numbness and tingling sensations from the sciatic nerve in the lower back, down the buttocks and thighs and through one or both legs and into the feet. Sciatica is commonly the result of irritation, inflammation or compression of the largest nerve in the human body, generally due to a herniated disc or bone spur.

 

blog picture of cartoon paperboy big news

 

IMPORTANT TOPIC: EXTRA EXTRA: Treating Sciatica Pain

 

 

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Close Accordion
Respiratory Health And Nutrition

Respiratory Health And Nutrition

Respiratory Health Abstract: Diet and nutrition may be important modifiable risk factors for the development,
progression and management of obstructive lung diseases such as asthma and chronic
obstructive pulmonary disease (COPD). This review examines the relationship between
dietary patterns, nutrient intake and weight status in obstructive lung diseases, at different
life stages, from in-utero influences through childhood and into adulthood. In vitro and
animal studies suggest important roles for various nutrients, some of which are supported by
epidemiological studies. However, few well-designed human intervention trials are available
to definitively assess the efficacy of different approaches to nutritional management of
respiratory diseases. Evidence for the impact of higher intakes of fruit and vegetables is
amongst the strongest, yet other dietary nutrients and dietary patterns require evidence from
human clinical studies before conclusions can be made about their effectiveness.

Keywords: respiratory disease; asthma; COPD; dietary patterns; antioxidants; vitamin C;
vitamin E; flavonoids; vitamin D; obesity; adipokines; undernutrition

1. Introduction:�Respiratory Health

Diet and nutrition are increasingly becoming recognized as modifiable contributors to chronic disease development and progression. Considerable evidence has emerged indicating the importance of dietary intake in obstructive lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) in both early life and disease development [1,2] and management of disease progression [3,4]. These�respiratory diseases are characterized by airway and systemic inflammation, airflow obstruction, deficits in lung function and significant morbidity and mortality, as well as being costly economic burdens [5,6]. Pharmacological management remains the mainstay for treatment of respiratory diseases, and while treatment options are advancing, dietary intake modification could be an important adjuvant to disease management and an important consideration for disease prevention. Dietary patterns as well as intake of individual nutrients have been evaluated in observational and experimental studies throughout life stages and disease stages to elucidate their role in respiratory diseases. This review concentrates on evidence regarding the role of dietary patterns, individual nutrients, weight status and adipokines in asthma and COPD.

2. Dietary Intake And Respiratory Diseases

2.1. Dietary Patterns:�Respiratory Health

Various dietary patterns have been linked to the risk of respiratory disease [7]. The Mediterranean diet has been found to have protective effects for allergic respiratory diseases in epidemiological studies [8]. This dietary pattern consists of a high intake of minimally processed plant foods, namely; fruit, vegetables, breads, cereals, beans, nuts and seeds, low to moderate intake of dairy foods, fish, poultry and wine and low intake of red meat. High intakes of olive oil result in a dietary composition that is low in saturated fat though still moderate in total fat. In children, several studies showed that adherence to the Mediterranean diet is inversely associated with atopy and has a protective effect on atopy, wheezing and asthma symptoms [9�11]. The Mediterranean diet may also be important for maternal diet, as a study in Spain found that a high Mediterranean diet score during pregnancy was protective for persistent wheeze and atopic wheeze in children at 6.5 years of age [12]. Though one cross-sectional study in Japan reported a strong association between the adherence to the Mediterranean diet and asthma control [13], there is less evidence available to support this dietary pattern in adults. The �western� dietary pattern, prevalent in developed countries, is characterised by high consumption of refined grains, cured and red meats, desserts and sweets, french fries, and high-fat dairy products [2,14]. This pattern of intake has been associated with increased risk of asthma in children [15,16]. Furthermore, in children, increased intake of fast food such as hamburgers and related eating behaviours, for example salty snack eating and frequent take away consumption, are correlated with the presence of asthma, wheezing and airway hyperresponsiveness (AHR) [17,18]. In adults, a western diet has been shown to be positively associated with increased frequency of asthma exacerbation [19], but not related to asthma risk. In addition, an acute challenge with a high fat fast food meal has been shown to worsen airway inflammation [20]. While this dietary pattern appears to be deleterious in children and adults with asthma, studies examining the effect of this dietary pattern in maternal diets have found no relationship with a consumption of a �western� style diet in pregnancy and risk of asthma in offspring [21]. Cross-sectional studies have also found that the �western� diet is associated with an increased risk of COPD [2]. In summary the Mediterranean diet appears to be protective in children, though there is less evidence for benefits in the maternal diet and in adults. There is evidence to suggest that a �western� style dietary pattern increases risk of asthma in children, has worse outcomes for adults with asthma and is related to COPD risk.

2.2. Fruit And Vegetables:�Respiratory Health

Fruit and vegetable intake has been investigated for potential benefits in association with respiratory conditions due to their nutrient profile consisting of antioxidants, vitamins, minerals, fibre and phytochemicals. The mechanisms by which the nutrients in fruit and vegetables exert beneficial effects in respiratory conditions are discussed in the sections below. Epidemiological evidence reviewed by Saadeh et al. [7] showed that fruit intake was associated with a low prevalence of wheezing and that cooked green vegetable intake was associated with a low prevalence of wheezing and asthma in school children aged 8�12 years old. Furthermore low vegetable intake in children was related to current asthma [7]. In adults, Grieger et al. [22] discusses the heterogeneous nature of the data describing fruit and vegetable intake and lung function, with one study showing no effect on lung function of higher fruit and vegetable intake over 10 years [23], yet in another study, increased fruit intake over 2 years was associated with increased FEV1 [23], while another study showed that a large decrease in fruit intake over 7 years was associated with decreased FEV1 [24]. We recently conducted an intervention in adults with asthma and found that subjects who consumed a high fruit and vegetable diet for 3 months, had a decreased risk of asthma exacerbation, compared to subjects who consumed a low fruit and vegetable diet [25]. A recent meta-analysis of adults and children, which analysed 12 cohorts, 4 population-based case-control studies, and 26 cross-sectional studies provides important new evidence showing that a high intake of fruit and vegetables reduces the risk of childhood wheezing, and that fruit and vegetable intake is negatively associated with asthma risk in adults and children [26]. While some studies of maternal diet have found no relationship with fruit and vegetable intake and asthma in children [27], other studies have found that increased fruit and vegetable intake were related to a decreased risk of asthma in children [21,28]. Increased fruit and vegetable intake may be protective against COPD development, with consumption of a �prudent� diet including increased fruit and vegetables being protective against lung function decline [3]. Two randomized controlled trials (RCT�s) manipulating fruit and vegetable intake have been conducted in COPD. A 12 week study showed no effect of a high fruit and vegetable intake on FEV1, systemic inflammation or airway oxidative stress [29]. However, a 3-year study in 120 COPD patients revealed an improvement in lung function in the high fruit and vegetable group compared to the control group [30], suggesting that longer term intervention is needed to provide a therapeutic effect. There is considerable evidence to suggest that a high intake of fruit and vegetables is favourable for all life stages of asthma and evidence is emerging which suggests the same in COPD.

2.3. Omega-3 Fatty Acids And Fish:�Respiratory Health

Omega-3 polyunsaturated fatty acids (PUFA) from marine sources and supplements have been shown to be anti-inflammatory through several cellular mechanisms including their incorporation into cellular membranes and resulting altered synthesis of eicosanoids [31]. Experimental studies have shown that long chain omega-3 PUFA�s decrease inflammatory cell production of pro-inflammatory prostaglandin (PG) E2, leukotriene (LT) B4 [32] and activity of nuclear factor-kappaB (NF-?B), a potent inflammatory transcription factor [33]. Long chain omega-3 PUFA�s also down regulate pro-inflammatory cell cytokine production (interleukin-1? (IL-1?), tumor necrosis factor-? (TNF-?)) by monocytes and macrophages, decrease expression of cellular adhesion molecules on monocytes and endothelial cells and reduce�production of ROS in neutrophils [34]. Saddeh et al. [7] reported that the evidence describing the relationship between omega-3 PUFA�s or fish consumption and respiratory conditions in childhood is contradictory. Some observational studies show that intake of oily fish is negatively associated with AHR and asthma [35,36]. However, evidence from Japan suggests that frequency of fish consumption is positively related to asthma risk [37] and in Saudi Arabia fish intake was not related to the presence of asthma or wheezing at all [18]. Similarly in adults, the data is heterogeneous, with omega-3 PUFAs or fish being associated with improved lung function [38] and decreased risk of asthma [39], AHR [35] and wheeze [36] in some, but not all studies [40]. Maternal dietary intake of oily fish was found to be protective of asthma in children 5 years of age if born to mothers with asthma [41] and a recent systematic review of omega-3 fatty acid supplementation studies in women during pregnancy found that the risk of asthma development in children was reduced [42]. The data examining the possible benefits of dietary omega-3 fatty acid supplementation in asthma are heterogeneous and as summarized by a 2002 Cochrane review [43], to date there is insufficient evidence to recommend omega-3 PUFA supplementation in asthma. Omega-3 PUFA may have positive effects in COPD, as higher levels of DHA in serum were found to decrease the risk of developing COPD [44]. Experimental studies in humans with COPD including supplementation with omega-3 found lower levels of TNF-? [45] and improved rehabilitation outcomes [46], though no improvements were seen in FEV1. Several studies using omega-3 PUFA supplementation in COPD are currently underway and will provide important new information to inform the field [47�49]. Consumption of oily fish or supplementation with omega-3 PUFA�s may have positive effects in asthma and COPD, though strong evidence to support the experimental and epidemiological data is not yet available.

3. Nutrients And Respiratory Disease

3.1. Antioxidants And Oxidative Stress

Dietary antioxidants are an important dietary factor in protecting against the damaging effects of oxidative stress in the airways, a characteristic of respiratory diseases [50]. Oxidative stress caused by reactive oxygen species (ROS), is generated in the lungs due to various exposures, such as air pollution, airborne irritants and typical airway inflammatory cell responses [51]. Also, increased levels of ROS generate further inflammation in the airways via activation of NF-?B and gene expression of pro-inflammatory mediators [52]. Antioxidants including vitamin C, vitamin E, flavonoids and carotenoids are abundantly present in fruits and vegetables, as well as nuts, vegetable oils, cocoa, red wine and green tea. Dietary antioxidants may have beneficial effects on respiratory health, from influences of the maternal diet on the fetus, and intake in children through to adults and pregnant women with asthma and adults with COPD. ?-tocopherol is a form of vitamin E, which helps maintain integrity of membrane fatty acids, by inhibiting lipid peroxidation [22]. Carotenoids are plant pigments and include; ?- and ?-carotene, lycopene, lutein and ?-cryptoxanthin. This group of fat soluble antioxidants have been shown to benefit respiratory health due to their ability to scavenge ROS and reduce oxidative stress [22]. The antioxidant lycopene, present predominantly in tomatoes, may be beneficial in respiratory conditions, indeed lycopene intake has been positively correlated with FEV1 in both asthma and COPD [53] and an�intervention study in asthma showed that lycopene supplementation could suppress neutrophilic airway inflammation [54]. Antioxidants may also be important in asthma during pregnancy, as while oxidative stress commonly increases during normal pregnancies, in women with asthma oxidative stress is heightened [55]. During pregnancy there is a compensatory increase in circulating and placental antioxidants in asthma versus women without asthma, to protect the foetus against damaging effects of oxidative stress [55,56]. Improving antioxidant intake in pregnant women with asthma may be beneficial as poor fetal growth outcomes are associated with low levels of circulating antioxidants and dietary antioxidants are the first defense mechanism against ROS [22]. Maternal intake of vitamin E, vitamin D, milk, cheese and calcium during pregnancy are negatively associated, while vitamin C is positively associated, with wheezing in early childhood [57,58]. Antioxidants including lycopene appear to have positive influences in respiratory conditions, further detail is provided below on evidence for vitamin C, vitamin E and flavonoids and their role in the maternal diet, diets of children and adults with asthma and adults with COPD.

3.2. Vitamin C:�Respiratory Health

Vitamin C has been enthusiastically investigated for benefits in asthma and links to asthma prevention. In vitro data from endothelial cell lines showed that vitamin C could inhibit NF-?B activation by IL-1, TNF-? and block production of IL-8 via mechanisms not dependent on the antioxidant activity of vitamin C [59]. Anti-inflammatory and anti-asthmatic effects of vitamin C supplementation in vivo, have been shown through allergic mouse models of asthma. Jeong et al. [60] reported decreased AHR to methacholine and inflammatory cell infiltration of perivascular and peribronchiolar spaces when vitamin C was supplemented during allergen challenge. While Chang et al. [61] found that high dose Vitamin C supplementation in allergen challenged mice decreased eosinophils in BALF and increased the ratio of Th1/Th2 cytokine production shifting the inflammatory pattern to Th1 dominant. Observational studies in children showed consumption of fruit, a rich source of vitamin C, was related to reduced wheezing [62] and vitamin C intake was negatively associated with wheezing [63], while another study reported no relationship between vitamin C intake and lung function [64]. Grieger et al. [22] also reported conflicting evidence for effects of vitamin C intake in adults, with epidemiological studies showing a positive association between vitamin C intake and lung function in some [65], but not all studies [23,66]. Despite the observational data linking vitamin C to lung health, supplementation with vitamin C has not been shown to reduce the risk of asthma [66] which may be related to the interdependence of nutrients found in foods, resulting in lack of efficacy when supplementing with isolated nutrients. Evidence from experimental and observational studies suggests that Vitamin C might be important in COPD pathogenesis and management. Koike et al. [67] reported that in knock out mice unable to synthesize vitamin C, vitamin C supplementation was able to prevent smoke induced emphysema and also to restore damaged lung tissue and decrease oxidative stress caused by smoke induced emphysema. A case control study in Taiwan reported that subjects with COPD had lower dietary intake and lower serum levels of vitamin C than healthy controls [68]. Indeed an epidemiological study in the United Kingdom of over 7000 adults aged 45�74 years found that increased plasma vitamin C concentration was associated with a decreased risk of obstructive airways disease, suggestive of a protective effect [69]. Thus, in summary, while observational data has suggested that vitamin C is important for lung health, intervention trials�showing efficacy are lacking and it appears that supplementation with vitamin C-rich whole foods, such
as fruit and vegetables may be more effective.

3.3. Vitamin E:�Respiratory Health

The vitamin E family comprises of 4 tocopherols and 4 tocotrienols, with the most plentiful in the diet or in tissues being ?-tocopherol and ?-tocopherol [70]. Vitamin E works synergistically with vitamin C, as following neutralisation of ROS, oxidised vitamin E isoforms can be processed back into their reduced form by vitamin C [71]. Abdala-Valencia et al. [72] discuss the evidence for the roles of ?-tocopherol and ?-tocopherol in allergic lung inflammation in mechanistic animal studies and clinical trials. Supplementation of mice with ?-tocopherol reduced allergic airway inflammation and AHR [73], while ?-tocopherol was pro-inflammatory and augmented AHR, negating the positive effects of ?-tocopherol [74]. Other animal studies report that ?-tocopherol may assist in resolving inflammation caused by ozone exposure and endotoxin induced neutrophilic airway inflammation, owing to its ability to oxidize reactive nitrogen species [75,76]. A study in humans showed that both ? and ?-tocopherol may be effective in decreasing LPS induced neutrophilic inflammation [77]. The conflicting results from these supplementation studies are likely to be influenced by baseline tissue levels of vitamin E [72], with ?-tocopherol supplementation leading to improved lung function and wheeze in Europe, where ?-tocopherol levels are low [78�80], but not in the US, where ?-tocopherol intake is high due to soybean oil consumption [81�83]. As a result, meta-analysis of vitamin E effects on asthma outcomes is equivocal; it is likely that supplementation with physiological concentrations of ?-tocopherol in the context of a background diet low in ?-tocopherol, may be most beneficial in asthma and further research testing this hypothesis is required. In COPD, serum levels of vitamin E have been shown to be decreased during exacerbation, which suggests increased intake may be helpful to improve vitamin E concentrations [84]. Vitamin E has been shown to reduce biomarkers of oxidative stress in adults with COPD in one RCT [85], but not another [86]. In the Women�s Health Study (n = 38,597), the risk of developing chronic lung disease over a 10 year supplementation period was reduced by 10% in women using vitamin E supplements (600 IU on alternate days) [87]. Dietary intake of vitamin E lower than recommended dietary intakes has been reported in pregnant women with a family history of allergic disease [88] and recent work in animal models has highlighted ?-tocopherol may be important for allergic mothers in pregnancy. Allergic female mice were supplemented with ?-tocopherol prior to mating and following allergen challenge the offspring showed reduced response to allergen challenge with decreased eosinophils in BALF [89]. The offspring also showed reduced development of lung dendritic cells, necessary for producing allergic responses. Evidence from observational studies also suggests that reduced maternal dietary intake of vitamin E is related to an increased risk of childhood asthma and wheeze [90�92] and increased in vitro proliferative responses in cord blood mononuclear cells (CBMC) [93]. A mechanistic study by Wassall et al. [94] examined the effect of ?-tocopherol and vitamin C on CBMC and maternal peripheral blood mononuclear cells (PBMC). ?-tocopherol was mostly anti-inflammatory, although increased proliferation and increased TGF-? were seen with some allergens. However, the addition of vitamin C to the system had inflammatory actions, with increased production of pro-inflammatory cytokines, combined with reduced production of IL-10 and TGF-?. This study by Wassall et al. [94] demonstrates that supplementation�with these antioxidants does modulate immune responses in pregnancy, however several of the results are unexpected, highlighting the complex nature of the relationships between dietary nutrients and disease. In asthma the experimental data for vitamin E are compelling, yet supplementation benefits are not well described. In COPD there is currently not enough evidence to make conclusions about vitamin E supplementation.

3.4. Flavonoids:�Respiratory Health

Flavonoids are potent antioxidants and have anti-inflammatory as well as anti-allergic actions due in part, to their ability to neutralise ROS [95]. There are 6 classes of flavonoids including flavones, flavonols, flavanones, isoflavones and flavanols [96], which are widely distributed throughout the diet and found in fruit, vegetables, nuts, seeds, stems, flowers, roots, bark, dark chocolate, tea, wine and coffee [96]. Tanaka et al. [95] present the evidence for the benefits of dietary flavonoids in asthma development and progression. In addition to reducing oxidative stress, in vitro experiments have found that many individual flavonoids have inhibitory effects on IgE mediated immune responses such as histamine secretion by mast cells, shift in cytokine production from Th-2 to Th-1 production and decreased NF-?B activation and inhibition of TNF-? [97�100]. Experimental studies of flavonoids in animal models of allergic asthma have shown reduced airway and peripheral blood inflammation, decreased bronchoconstriction and AHR and lower eosinophils in BALF, blood and lung tissue [101�104]. In humans, evidence from a case control study in adults showed that apple and red wine consumption, rich sources of flavonoids, was associated with reduced asthma prevalence and severity [66]. However a follow-up study investigating intake of 3 subclasses of flavonoids did not find any associations with asthma prevalence or severity [105]. There are a limited number of experimental studies using flavonoid supplements in humans with asthma. Three RCT�s in adults with asthma using a product called pycnogenol, which contains a mixture of bioflavonoids, reported benefits including increased lung function, decreased symptoms and reduced need for rescue inhalers [106]. There is a paucity of evidence for the effects of flavonoids in the maternal diet and respiratory outcomes in children. One study which found a positive association of maternal apple intake and asthma in children at 5 years, suggests that the flavonoid content of apples may be responsible for the beneficial relationship [107]. Evidence for the effects of flavonoids in respiratory conditions is emerging and promising. Though like vitamin C, it may be difficult to disentangle the effects of flavonoids from other nutrients in flavonoid-rich foods. Supplementation of individual flavonoids in experimental animal studies has provided evidence to suggest that intervention trials in humans may be warranted.

3.5. Vitamin D:�Respiratory Health

Epidemiological studies show promising associations between vitamin D and lung health; however the mechanisms responsible for these effects are poorly understood. Vitamin D can be obtained from dietary sources or supplementation; however sun exposure is the main contributor to vitamin D levels [108]. While vitamin D has beneficial effects independent of UV exposure [109], it can be difficult to separate this potential confounder from direct effects of vitamin D on lung health [110]. The review by Foong and Zosky [111] presents the current evidence for the role of vitamin D deficiency in disease onset, progression and exacerbation in respiratory infections, asthma and COPD. Respiratory infections contribute to disease progression and exacerbation in both COPD and asthma. Vitamin D appears to have a protective role against the susceptibility to and severity of these infections [111], as active vitamin D (1,25 (OH)2D) modifies production of antimicrobial cathelicidins and defensins that kill bacteria and induce wound repair [112]. Activated vitamin D also decreases the expression of rhinovirus receptors in endothelial cell cultures and PBMC�s [113]. In vitro studies also support the link between vitamin D and airway remodelling as active vitamin D inhibits airway smooth muscle (ASM) cell proliferation [114] and deficiency impairs normal lung development [115]. Furthermore, animal models suggest that vitamin D can inhibit Th1 and Th2 cell cytokine production [116]. Epidemiological evidence links low levels of vitamin D with wheeze and respiratory infections, though evidence for the link with asthma onset is weak and inconsistent [111]. In children, low circulating vitamin D was related to lower lung function, increased corticosteroid use and exacerbation frequency [117]. Also in children with steroid resistant asthma, low vitamin D was related to increased ASM thickness [117]. Other observational studies report that in children, low levels of vitamin D are associated with asthma exacerbation [118]. Several observational studies support the role of vitamin D for protection against respiratory conditions in children. Zosky et al. [119] found that vitamin D deficiency at 18 weeks gestation was associated with lower lung function and current wheeze in children 6 years of age and an increased risk of asthma in boys. The role for vitamin D in enhancing steroid responsiveness suggested by observational studies [120] is supported by mechanistic studies [121], and in concert with the actions of vitamin D in infection, may explain the effect of vitamin D in reducing asthma exacerbations [111]. Only one intervention trial has been conducted using vitamin D in adults with asthma, which found that rate of first exacerbation was reduced in subjects who demonstrated an increase in circulating vitamin D3 following supplementation [122]. Data for the role of vitamin D in COPD onset is limited, though several cross-sectional studies have reported an association between low vitamin D levels, or deficiency, with COPD incidence [123]. Blood vitamin D levels have also been correlated with lung function in COPD patients [124,125]. Experimental data suggest that vitamin D may be important in COPD for its effect on normal lung growth and development, though human data to support this is not available. It is possible that COPD onset may also be impacted by cellular responses to cigarette smoke exposure which inhibits the protective immunomodulatory effects of vitamin D [126]. There is research suggesting a genetic link between vitamin D and COPD pathogenesis. In an observational study single nucleotide polymorphisms in the vitamin D binding protein (VDBP) predicted vitamin D levels in COPD patients and were found to be a risk factor for COPD [123]. The VDBP is also involved in macrophage activation as high levels of airway VDBP are related to increased macrophage activation, also high levels of serum VDBP were found to be related to lower lung function [127]. COPD progression may also be affected by vitamin D status through absence of the vitamin D receptor and parenchyma degradation [128]. COPD exacerbations are generally caused by viral or bacterial lung infections, and though vitamin D has a positive role in reducing infection, there is no evidence to support that vitamin D is associated with ameliorating exacerbations in COPD patients [129]. The extra-skeletal effects of vitamin D are well documented in both asthma and COPD, and deficiency is associated with negative respiratory and immune outcomes. At this stage however, more evidence from supplementation interventions is needed before widespread adoption of supplementation can be recommended.

3.6. Minerals:�Respiratory Health

Some minerals have also been found to be protective in respiratory conditions. In children, increased intake of magnesium, calcium and potassium is inversely related to asthma prevalence [7]. While several observational and experimental trials have been performed with conflicting results [130], a randomised controlled trial concluded that a low sodium diet had no therapeutic benefit for bronchial reactivity in adults with asthma [131]. Dietary magnesium may have beneficial bronchodilator effects in asthma [132]. Low dietary magnesium intake has been associated with negative effects on bronchial smooth muscle in severe asthma [133] and with lower lung function in children [134]. However further evidence of positive therapeutic effects are required before its importance in asthma and recommendations can be determined [135]. Dietary intake of selenium has been shown to be lower in asthmatics compared to non-asthmatics [136] and maternal plasma selenium levels were reported to be inversely associated with risk of asthma in children [137]. However case control studies in children have not found a relationship with selenium levels or intake with asthma related outcomes [18,138]. Furthermore, results from a large well designed RCT in adults with asthma showed no positive benefit of selenium supplementation [139]. Investigation of minerals in cord blood imply the importance of adequate intake during pregnancy, as levels of cord blood selenium were negatively associated with persistent wheeze, and levels of iron were negatively associated with later onset wheeze in children [140]. Studies on dietary intake of minerals and associations with COPD are sparse. A small study in Sweden found that in older subjects with severe COPD, intakes of folic acid and selenium were below recommended levels, and although intake of calcium was adequate, serum calcium levels were low, likely related to their vitamin D status as intake was lower than recommended [141]. Mineral intake may be important in respiratory diseases, yet evidence for supplementation is weak. It is likely that adequate intake of these nutrients in a whole diet approach is sufficient.

4. Obesity, Adipokines And Respiratory Disease

Overnutrition and resulting obesity are clearly linked with asthma, though the mechanisms involved are still under investigation. The review by Periyalil et al. [142] describes how immunometabolismadipose tissue derived immunological changes causing metabolic effects [143] contributes to the link between asthma and obesity. In the obese state dietary intake of lipids leads to increased circulating free fatty acids [144], which activate immune responses, such as activation of TLR4, leading to increased inflammation, both systemically and in the airways [20]. Adipose tissue also secretes adipokines and asthmatic subjects have higher concentrations of circulating leptin than healthy controls [14] which are further increased in females, though leptin is associated with BMI in both males and females [145]. Leptin receptors are present in the bronchial and alveolar epithelial cells and leptin has been shown to induce activation of alveolar macrophages [146] and have indirect effects on neutrophils [147]. Also leptin promotes Th1 proliferation inducing increased activation of neutrophils by TNF-? [148]. In vitro, leptin also activates alveolar macrophages taken from obese asthmatics, which induces airway inflammation through production of pro-inflammatory cytokines [149]. However, a causal role for leptin in the obese asthma relationship is yet to be established. Adiponectin, an anti-inflammatory adipokine, has beneficial effects in animal models of asthma [150], however, positive associations in human studies have only been seen in women [151]. In obesity, macrophage and mast cell infiltration into adipose tissue is upregulated [142]. Neutrophils also appear to dominate airway inflammation in the obese asthma phenotype [152], particularly in females [153], which may explain why inhaled corticosteroids are less effective in achieving control in obese asthma [154]. While the mechanisms are yet to be understood, a recent review reports that obesity in pregnancy is associated with higher odds of asthma in children, with increased risk as maternal BMI increases [155].

COPD is characterised not only by pulmonary deficits but also by chronic systemic inflammation and co-morbidities which may develop in response to the metabolic dysregulation that occurs with excess adipose tissue [156]. A recent meta-analysis of leptin levels in COPD reported a correlation with body mass index (BMI) and fat mass percent in stable COPD though absolute levels were not different to healthy controls [157]. During exacerbation, leptin levels increased and were positively associated with circulating TNF-? [157]. Bianco et al. [158] describes the role of adiponectin and its effect on inflammation in COPD. Adiponectin has anti-inflammatory effects and is present in high concentrations in serum of healthy subjects [159]. Adiponectin exists in several isoforms, which have varied biological effects [160] and interact with two receptors present in the lungs (AdipoR1 and AdipoR2) that have opposing effects on inflammation [161]. Single nucleotide polymorphisms in the gene encoding adiponectin are associated with cardiovascular disease, obesity and the metabolic syndrome [162]. The role of adiponectin in COPD however is not well understood. In COPD, serum adiponectin is increased and directly relates to disease severity and lung function decline [163]. There is an alteration in the oligomerisation of adiponectin in COPD resulting in increased concentrations of the anti-inflammatory higher-molecular weight isoform [164], and the expression of adiponectin receptors in the lung is also altered in comparison to healthy subjects [165]. Animal models have shown anti-inflammatory effects of adiponectin in the lung through the increased expression of TNF-? in alveolar macrophages in adiponectin deficient mice [166]. Further mechanistic studies have also shown the anti-inflammatory potential of adiponectin by reducing the effects of TNF-?, IL-1? and NF-?B and increasing expression of IL-10 through interaction with AdipoR1 [161]. However under certain conditions in cell lines and animal models adiponectin has been shown to have pro-inflammatory effects [167,168]. As both detrimental and protective effects have been seen, the complex modulation of adiponectin isoforms and receptors in COPD requires further exploration. Obesity, the resulting systemic inflammation and alterations in adipokines have significant negative effects in both asthma and COPD. While work examining the mechanisms of effect is extensive, evidence for interventions to improve the course of disease are limited to weight loss interventions in asthma at this stage.

5. Undernutrition And Respiratory Disease

Though underweight has not been well studied in asthma, an observational study in Japan reported that subjects with asthma who were underweight had poorer asthma control than their normal weight counterparts [169]. While there is widespread acknowledgement that malnutrition in pregnant women adversely effects of the lung development of the fetus [170], a recent review reported that the offspring of mothers who were underweight did not have an increased risk of asthma. Amongst the obstructive lung diseases, undernutrition is most commonly recognized as a feature of COPD. Itoh et al. [171] present a review on undernutrition in COPD and the evidence for nutritional therapy in management�of the disease. Weight loss, low body weight and muscle wasting are common in COPD patients with advanced disease and are associated with reduced survival time and an increased risk of exacerbation [172]. The causes of undernutrition in COPD are multifactorial and include reduced energy intake due to decreased appetite, depression, lower physical activity and dyspnoea while eating [173]. In addition, resting energy expenditure is increased in COPD, likely due to higher energy demands from increased work of breathing [174]. Also, systemic inflammation which is a hallmark of COPD, may influence energy intake and expenditure [175]. Cigarette smoke may also have deleterious effects on body composition in addition to the systemic effects of COPD. Smoking causes muscle fibre atrophy and decreased muscle oxidative capacity shown in cohorts of non-COPD smokers [176,177] and in animal models of chronic smoke exposure [178,179]. The mechanisms underlying muscle wasting in COPD are complex and multifaceted [180]. Increased protein degradation occurs in the whole body, though it is enhanced in the diaphragm [181]. Protein synthesis pathways are altered, indeed insulin like growth factor-1 (IGF-1) which is essential for muscle synthesis is decreased in cachectic COPD patients [182] and is lower in COPD patients during acute exacerbation, compared to healthy controls [183]. Increased oxidative stress, due to increased mitochondrial ROS production, occurs both systemically and in muscle tissue in cachectic COPD patients and is negatively associated with fat free mass (FFM) and muscle strength in COPD patients [184]. Furthermore myostatin induces muscle atrophy by inhibiting proliferation of myoblasts and mRNA expression of myostain is increased in cachectic COPD patients and is related to muscle mass [185]. Systemic inflammatory mediators such as TNF-? and NF-?B are also implicated in COPD muscle atrophy [186,187]. Nutritional supplementation therapy in undernourished COPD patients has been shown to induce weight gain, increase fat free mass, increase grip strength and exercise tolerance as well as improve quality of life [188]. Further studies point out the importance of not only high energy content, but also macronutrient composition of the nutritional supplement and inclusion of low intensity respiratory rehabilitation exercise [189,190]. Other dietary nutrients have been investigated for the benefits in COPD. Creatinine, found in meat and fish, did not have additive effects to rehabilitation, while sulforaphane, found in broccoli and wasabi, and curcumin, the pigment in turmeric, may have beneficial antioxidant properties [191�193]. Branched chain amino acid supplementation in COPD is associated with positive results including increases in whole body protein synthesis, body weight, fat free mass and arterial blood oxygen levels [194,195]. Undernutrition is not a significant problem in asthma, though is a major debilitating feature of COPD. There is promising evidence that nutritional supplementation in COPD is important and can help to alleviate some of the adverse effects of the disease, particularly muscle wasting and weight loss.

6. Conclusions: Respiratory Health

Dietary intake appears to be important in both the development and management of respiratory diseases, shown through epidemiological and cross-sectional studies and supported by mechanistic studies in animal models. Although more evidence is needed from intervention studies in humans, there is a clear link for some nutrients and dietary patterns. The dietary patterns associated with benefits in respiratory diseases include high fruit and vegetable intake, Mediterranean style diet, fish and omega-3 intake, while fast food intake and westernized dietary�patterns have adverse associations. Figure 1 shows a diagrammatic representation of the relationships of nutrition and obstructive lung diseases.

respiratory

Respiratory Health

Though antioxidants are associated with positive effects on inflammation, clinical outcomes and respiratory disease prevention, intervention studies of individual antioxidants do not indicate widespread adoption of supplementation [196]. Differences in results from individual studies including whole foods such as fruit and vegetables and fish could be influenced by the nutritional profile owing to the region it was grown or produced. In considering studies using single nutrients it is also important to acknowledge that nutrients in the diet are consumed as whole foods that contain other micronutrients, fibre and compounds with both known and unknown anti and pro-inflammatory potential. Furthermore investigations of single nutrients should ideally control for other antioxidants and dietary sources of pro-inflammatory nutrients. While this limitation is common, it is a significant challenge to control for dietary intake of other nutrients in clinical trials. A whole foods approach to nutrient supplementation�for example, increasing intake of fruit and vegetables, has the benefit of increasing intake of multiple nutrients, including vitamin C, vitamin E, carotenoids and flavonoids and shows more promise in respiratory diseases in terms of reducing risk of COPD [3] and incidence of asthma exacerbations [25].

The evidence for mechanisms of vitamin D in lung development and immune function are yet to be fully established. It appears that vitamin D is important in respiratory diseases and infections, however the temporal role of vitamin D deficiency in disease onset, pathogenesis and exacerbations and whether supplementation is indicated is yet to be clarified.

Overnutrition in respiratory disease is clearly associated with adverse effects, highlighted by detrimental effects induced by immunometabolism. Further understanding of the relationship between mediators of immunometabolism and respiratory diseases and their mechanisms may provide therapeutic options. Undernutrition still poses risk in some respiratory conditions. Appropriate nutritional supplementation in advanced COPD is indicated, and several nutrients appear to be beneficial in COPD development and exacerbation.

The field of nutrition and respiratory disease continues to develop and expand, though further work is required in the form of randomized controlled dietary manipulation studies using whole foods to enable provision of evidence based recommendations for managing respiratory conditions.

Bronwyn S. Berthon and Lisa G. Wood *

Centre for Asthma and Respiratory Diseases, Level 2, Hunter Medical Research Institute,
University of Newcastle, Lot 1 Kookaburra Circuit, New Lambton Heights, NSW 2305, Australia;
E-Mail: bronwyn.berthon@newcastle.edu.au

* Author to whom correspondence should be addressed; E-Mail: lisa.wood@newcastle.edu.au;
Tel.: +61-2-4042-0147; Fax: +61-2-4042-0046.

Author Contributions

Bronwyn Berthon and Lisa Wood contributed to the study concept and design and were both involved in the preparation and completion of the manuscript.

Conflicts of Interest

The authors declare no conflicts of interest.

� 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article
distributed under the terms and conditions of the Creative Commons Attribution license
(creativecommons.org/licenses/by/4.0/).

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