Back Clinic Neuropathy Treatment Team. Peripheral neuropathy is a result of damage to peripheral nerves. This often causes weakness, numbness, and pain, usually in the hands and feet. It can also affect other areas of your body. The peripheral nervous system sends information from the brain and spinal cord (central nervous system) to the body. It can result from traumatic injuries, infections, metabolic problems, inherited causes, and exposure to toxins. One of the most common causes is diabetes mellitus.
People generally describe the pain as stabbing, burning, or tingling. Symptoms can improve, especially if caused by a treatable condition. Medications can reduce the pain of peripheral neuropathy. It can affect one nerve (mononeuropathy), two or more nerves in different areas (multiple mononeuropathies), or many nerves (polyneuropathy). Carpal tunnel syndrome is an example of mononeuropathy. Most people with peripheral neuropathy have polyneuropathy. Seek medical attention right away if there is unusual tingling, weakness, or pain in your hands or feet. Early diagnosis and treatment offer the best chance for controlling your symptoms and preventing further damage to the peripheral nerves. Testimonies http://bit.ly/elpasoneuropathy
The information herein is not intended to replace a one-on-one relationship with a qualified healthcare professional or licensed physician and is not medical advice. We encourage you to make your own health care decisions based on your research and partnership with a qualified health care professional. Our information scope is limited to chiropractic, musculoskeletal, physical medicines, wellness, sensitive health issues, functional medicine articles, topics, and discussions. We provide and present clinical collaboration with specialists from a wide array of disciplines. Each specialist is governed by their professional scope of practice and their jurisdiction of licensure. We use functional health & wellness protocols to treat and support care for the injuries or disorders of the musculoskeletal system. Our videos, posts, topics, subjects, and insights cover clinical matters, issues, and topics that relate to and support, directly or indirectly, our clinical scope of practice.* Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We provide copies of supporting research studies available to regulatory boards and the public upon request.
We understand that we cover matters that require an additional explanation of how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.
Dr. John Coppola and Dr. Valerie Monteiro understand the symptoms associated with peripheral neuropathy. While many healthcare professionals describe peripheral neuropathy as an irreversible and permanent health issue which can only be managed through the utilization of drugs/medications, Dr. John Coppola and Dr. Valerie Monteiro can help treat peripheral neuropathy symptoms by treating the source of the health issue.
Low-level laser therapy (LLLT) is a non-invasive treatment approach that can help naturally increase oxygen, blood flow, and circulation in the human body. LLLT can also stimulate the mitochondria, often known as the powerhouses of the cell, to stimulate recovery in the human body. Dr. John Coppola and Dr. Valerie Monteiro explain how low-level laser therapy can help treat peripheral neuropathy symptoms and stimulate overall well-being. Dr. Alex Jimenez, a chiropractor in El Paso, TX, can help treat peripheral neuropathy symptoms as well as a variety of other health issues.
Low-Level Laser Therapy (LLT) for Peripheral Neuropathy El Paso, TX.
Neuropathy is a medical term used to describe a collection of general diseases or malfunctions which affect the nerves.
The causes of neuropathy, or nerve damage, can vary among individuals and these may be caused by different:
Diseases
Injuries
Infections
Vitamin deficiencies
Neuropathy can also be classified according to the location of the nerves being affected and according to the disease-causing it.
Furthermore, depending on which nerves are affected will depend on the symptoms that will manifest.
Peripheral neuropathy is simply referred to as neuropathy, which is a state that happens when the nerves become damaged or injured, oftentimes simply disturbed.
It�s estimated that neuropathy affects roughly 2.4 percent of the general populace and approximately 8 percent of people older than age 55.
Type
Neuropathy can affect any of the three types of peripheral nerves:
Sensory nerves�transmit messages from sensory organs:
Eyes
Nose
Brain
Motor nerves track the movement of the muscles
Autonomic nerves regulate the involuntary body functions
Sometimes, neuropathy will only impact one nerve. This is medically referred to as mononeuropathy and instances of it include:
Ulnar neuropathy affects the elbow
Radial neuropathy affects the arms
Peroneal neuropathy affects the knees
Femoral neuropathy affects the thighs
Cervical neuropathy affects the neck
Sometimes, two or more isolated nerves in separate regions of the body can become damaged, injured or disrupted, resulting in mono neuritis multiplex neuropathy.
Most of the time, multiple peripheral nerves malfunction at the same time, a condition called polyneuropathy.
Cause
Neuropathies are often inherited from birth or they develop later in life.
The most frequent inherited neuropathy is the Charcot-Marie-Tooth disease, which affects 1 in 2,500 people in the USA.
Although healthcare professionals are sometimes not able to pinpoint the exact reason for an acquired neuropathy, medically referred to as idiopathic neuropathy.
There are many known causes for them, including:
Systemic diseases – a systemic disease is one that affects the whole body.
Physical trauma
Infectious diseases
Autoimmune disorders
The most frequent systemic cause behind peripheral neuropathy is diabetes, which can lead to chronically high blood glucose levels that harm nerves.
Other systemic issues can cause neuropathy, including:
Kidney disorders permit high levels of nerve-damaging toxic chemicals to flow in the blood
Toxins from exposure to heavy metals include:
Arsenic
Lead
Mercury
Thallium
Drugs/medications, including anti-cancer medications, anticonvulsants, antivirals, and antibiotics
Chemical imbalances because of liver illnesses.
Hormonal diseases, like hyperthyroidism, which disturbs metabolic processes, and potentially induces cells and body parts to exert pressure on the nerves.
Deficiencies in vitamins, such as E, B1 (thiamine), B6 (pyridoxine), B12, and niacin can be vital for healthy nerves.
Alcohol abuse induces vitamin deficiencies and could harm nerves.
Cancers and tumors can exert damaging pressure on nerve fibers and paths.
Chronic inflammation can damage protective tissues around nerves, which makes them more vulnerable to compression, getting inflamed and swollen.
Blood diseases and blood vessel damage, which may damage or injure nerve tissue by decreasing the available oxygen supply
Symptoms
Depending on the reason and unique to each patient, signs, and symptoms of neuropathy can include:
Symptoms are dependent on autonomic, sensory, or motor nerves or a combination are affected.
Autonomic nerve damage can start a chain reaction of physiological functions like blood pressure or create gastrointestinal problems and issues.
Damage or dysfunction in the sensory nerves may impact sensations and sense of equilibrium or balance, while injury to motor nerves affects movement and reflexes.
When both sensory and motor nerves are involved, the condition is known as sensorimotor polyneuropathy.
Complications
Peripheral�neuropathy�may result in several complications, as a result of disease or its symptoms.
Numbness from the ailment can allow you to be less vulnerable to temperatures and pain, making you more likely to suffer from burns and serious wounds.
The lack of sensations in the feet, for instance, can make you more prone to developing infections from minor traumatic accidents, particularly for diabetics, who heal more slowly than other people, including foot ulcers and gangrene.
Furthermore, muscle atrophy may cause you to develop particular physical disfigurements, such as pes cavus, a condition marked by an abnormally high foot arch, and claw-like deformities in the feet and palms.
Treatment
The first step in neuropathy treatment should be finding the root cause that’s causing the neuropathy.
Treatment of diseases such as:
Diabetes
Guillain-Barre syndrome
Rheumatoid arthritis
Sarcoidosis
Other underlying diseases
Prevents continued nerve damage and in cases heals the damaged nerves.
If you are unaware of any underlying disease that is causing the peripheral neuropathy, make sure to let your doctor know of abnormal symptoms.
Medication
Peripheral neuropathy can be treated with various medications.
The first type used to treat mild symptoms are:
Over-the-counter pain medications
In more severe cases:
Opiates
Narcotic medications
Anti-seizure medications
A doctor may prescribe a lidocaine patch or anti-depressants to relieve symptoms.
Patients should thoroughly discuss�neuropathymedication with a doctor before proceeding.
Chiropractic/Massage/Physical Therapy
Various manual therapies can benefit symptoms in neuropathy treatment.
A therapist or chiropractor will perform various manipulation techniques, and teach exercises and stretches to help improve symptoms combined with increased muscle strength/control.
A therapist may also recommend braces or splints to improve mobility.
Patients should attend all physical therapy sessions to gain maximum benefits.
Low-level-laser-therapy LLT
The primary and most debilitating symptom of diabetic peripheral neuropathy is a sensation of tingling, prickling, buzzing, pinching, burning, and/or sharp jabbing stabbing pain in the feet.
Low-Level Laser Therapy (LLLT) takes information from the receptors on the membrane of the cell and mitochondrion or the engine of the cell.
This information reaches the cell’s DNA, that directly controls cell function.
When cells receive better information, they work better, along with the tissues they make up like:
Bones
Cartilage
Tendons
Ligaments
LLT promotes the healing and regeneration of damaged tissues,� and its�systemic effects on tissue function are also carried throughout the body by blood and meridians or energy channels.
The key basic physiological effects of low-level laser light include:
Increased cell membranepolarization/permeability
Adenosine-5-triphosphate (ATP) production and respiratory activity
Enzyme activity
Collagen and epithelial production
Capillary formation
Macrophage (immune system) activity
Analgesic effects due to elevated endorphin production
Electrolytic nerve blockage
Improved blood and lymph flow
An anti-inflammatory effect from improved circulation and accelerated tissue regeneration
Increased production of antioxidants
An additional benefit is that the light energy from low-level lasers will only be absorbed by cells and tissues that are not functioning normally and do not go after healthy cells.
Low-level laser therapy has the potential of providing an effective means of reducing low back pain that is:
Simple
Quick
Non-invasive
Side-effect free
Acids
Supplements like:
Essential acids called ALA (alpha-Lipoic acid)
GLA (gamma-linolenic acid) and omega-3 fatty acids
These can have a beneficial effect on diabetic peripheral neuropathy.
L-Carnitine
L-carnitine is a substance that the body makes and stores in the:
Liver
Brain
There have been reports that certain diabetics with neuropathy symptoms could regain regular sensation in the limbs when they increased their consumption of carnitine called acetyl-L-carnitine.
Red meat
Peanut butter
Dairy products
Are good dietary sources of this nutrient.
Supplements are also available at health food stores and pharmacies and health/wellness clinics.
While every type of neuropathy, such as diabetic neuropathy or autoimmune disease-associated neuropathy, develops its own unique group of symptoms, many patients will often report common complaints. Individuals with neuropathy generally describe their pain as stabbing, burning or tingling.�Low-level laser therapy can help relieve these symptoms.
If you experience unusual or abnormal tingling or burning sensations, weakness and/or pain in your hands and feet, it�s essential to seek immediate medical attention in order to receive a proper diagnosis of the cause of your specific signs and symptoms. Early diagnosis can help prevent further nerve injury.� And early laser treatment can help before symptoms really become severe. Visit www.neuropathycure.org.
Of all of the wide array of health issues that healthcare professionals talk to their patients about, there is one which is tremendously overlooked and not taken seriously: brain fog. Many people suffer from brain fog and fatigue and unfortunately, many people are left to fend for themselves when it comes to this health issue. Patients describe feeling as if they’re living in a haze, their lives passing them by. Instead of being engaged in the present moment, patients describe feeling as though they’re seeing life from a distance. Their thinking is no longer sharp, and their brilliant minds are sidelined. �
Why do health issues like these fall through the cracks of conventional medicine? This may be because there’s currently no definitive treatment available for brain fog. The purpose of the following article is to discuss the causes of inflammation and brain fog. Understanding the reasons for this type of health issue may hopefully help shine a new light on future treatments. �
Brain Fog and Inflammation
Inflammation is an essential part of the immune system. We need inflammation to protects us from injury, infection, and illness. However, as with everything else in the human body, it is all about balance. An excessive amount of inflammation can cause the blood-brain barrier (BBB) to become more permeable, leading to brain inflammation. Neuroinflammation is sometimes known as “leaky brain syndrome” and this inflammatory oxidative stress (OS) in the hypothalamus of the brain is ultimately believed to be the root cause of brain fog, among other neurological diseases, such as Alzheimer’s disease. �
Hidden Causes of Inflammation and Brain Fog
“Brain fog”, however, is very much considered to be a general term for the actual health issue. The name tells you exactly what it is (diminished brain function), however, it doesn’t exactly tell you what’s causing the brain inflammation in the first place. Let’s dig deeper into the reasons for brain fog. We will describe the main causes of brain fog, according to researchers. �
Thyroid Problems
Every cell in the human body depends on thyroid function to be healthy and to be able to operate at full capacity. Thyroid hormone imbalances have been demonstrated to cause inflammatory reactions. The thyroid functions by receiving the proper messages in the brain during the hypothalamic-pituitary-thyroid (HPT) axis. Therefore, if the hypothalamus is inflamed, it can cause dysfunction in the brain-thyroid axis. The final result? A vicious cycle of inflammation. �
Adrenal Fatigue
As you’ve got the brain-thyroid axis, you also have the brain-adrenal (HPA) axis. Dysfunctions of the hormonal circadian rhythm are known as an adrenal disorder. During fatigue, your stress hormone cortisol can be found all over the region and this imbalance can stress out your system. The same as thyroid problems, brain fog can be both the cause and the consequence of adrenal fatigue because of the brain-hormone connection, among other essential functions in the body. �
Viral Infections
Low-grade chronic viral infections, such as Epstein-Barr virus (EBV), are connected to a wide array of inflammatory ailments like chronic fatigue syndrome. The brain needs vitamin D to flourish and EBV has been demonstrated to actually block the body from utilizing it. Viral infections, if left untreated, can also trigger excess inflammation, leading to many health issues.
Leaky Gut Syndrome
The gut and the brain are unmistakenly connected, they are even formed from the exact same fetal tissue when you’re growing in your mother’s uterus. According to a variety of research studies, leaky gut syndrome is associated with an increase in gut toxins, known as LPS, which have been demonstrated to affect inflammation and brain fog. �
Candida Overgrowth
Researchers state that excess yeast in the microbiome, by way of instance, candida overgrowth, can also ultimately increase the inflammatory cells IL-1, IL-6, and TNF, which may contribute to too much inflammation in the human brain and body. �
Histamine Intolerance
Several people, especially people with all of the gut problems mentioned above, are more prone to experiencing something known as histamine intolerance. This happens when the body does not break down the cell histamine and it causes a discharge of superoxide, a well-known free radical which brings about a lot of inflammation and other health issues. �
Inflammatory Foods
Inflammatory foods high in sugar, gluten (wheat, rye, barley, spelt, and oats), or casein (dairy products) are a problem for many men and women. Free radical harm can triple by higher blood glucose levels from these inflammatory foods. �
Toxins
Toxins like mold and heavy metals are just two overlooked factors that can contribute to brain fog in patients. �
Poor Sleep
If you’re not sleeping properly at night, you don’t need me to tell you that it affects your brain health. The antioxidant glutathione, which increases stress from the hypothalamus, can ultimately cause brain fog due to a lack of sleep. �
Methylation Impairments
Methylation is a big biochemical superhighway that happens 1 billion times every second in the human body. It makes your brain healthy and it can help detox your body. People who have hereditary methylation problems may often have a difficult time detoxing and their body may ultimately not be able to regulate or manage inflammation, including neuroinflammation. �
Brain inflammation has been associated with a variety of signs and symptoms, including brain fog. Inflammation in the brain can also cause a variety of neurological diseases, such as Alzheimer’s disease. Inflammation is an essential function of the human body, however, too much brain inflammation, can cause brain fog and other health issues. In the following article, inflammation and brain fog can be caused by a variety of factors, including leaky gut syndrome and inflammatory foods, among others. – Dr. Alex Jimenez D.C., C.C.S.T. Insight
Metabolic Assessment Form
The following Metabolic Assessment Form can be filled out and presented to Dr. Alex Jimenez. Symptom groups listed on this form are not intended to be utilized as a diagnosis of any type of disease, condition, or any other type of health issue. �
In honor of Governor Abbott’s proclamation, October is Chiropractic Health Month. Learn more about the proposal. �
Of all of the wide array of health issues that healthcare professionals talk to their patients about, there is one which is tremendously overlooked and not taken seriously: brain fog. Many people suffer from brain fog and fatigue and unfortunately, many people are left to fend for themselves when it comes to this health issue. The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or chronic disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 . �
Curated by Dr. Alex Jimenez �
References:
Cole, William. �Here’s Exactly What To Do About Brain Fog: A Functional Medicine Expert Explains.� Mindbodygreen, Mindbodygreen, 17 Feb. 2017, www.mindbodygreen.com/0-28772/heres-exactly-what-to-do-about-brain-fog-a-functional-medicine-expert-explains.html.
Additional Topic Discussion: Chronic Pain
Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals, however, chronic pain is different than the average type of pain. With chronic pain, the human body will continue sending pain signals to the brain, regardless if the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient’s mobility and it can reduce flexibility, strength, and endurance.
Neural Zoomer Plus for Neurological Disease
� �
Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual�s reactivity to 48 neurological antigens with connections to a variety of neurologically related diseases. The Vibrant Neural ZoomerTM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention. �
Formulas for Methylation Support
XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly,�Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic�Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
�
For your convenience and review of the XYMOGEN products please review the following link.*XYMOGEN-Catalog-Download �
* All of the above XYMOGEN policies remain strictly in force.
Inflammation is the human body’s natural response to injury, infection, or illness. However, too much inflammation can affect your overall health and wellness, especially when you have inflammation in the brain. Brain inflammation can even affect your mental and emotional well-being. Understanding the causes and symptoms of inflammation in the brain can help determine the best treatment option. Dr. Santosh Kesari describes that brain inflammation can be due to various reasons, including toxins like tobacco or alcohol, diabetes, hypertension, infections, trauma, aging, diet, and stress. �
“Some inflammation is acute, short-lasting, and possibly reversible but other types of inflammation are chronic and continue to cause brain damage,” Dr. Kesari states. “These may be cumulative and not readily reversible, such as Alzheimer’s disease.” With an overactive immune system, such as in people who have multiple sclerosis or encephalitis which is inflammation in the brain, several people may already be genetically predisposed to experience brain inflammation. Severe inflammation can lead to a variety of symptoms, it may also result in coma, brain damage, or death. The following 7 signs and symptoms may indicate inflammation in the brain. Make sure to seek immediate medical attention if brain inflammation is suspected. �
Brain Fog
If we’re talking about chronic inflammation caused by exposure to toxins or due to poor lifestyle habits, brain fog, as well as decreased cognitive abilities, can be some signs and symptoms of inflammation in the brain. You may ultimately lose your train of thought constantly when you have brain fog and you’ll frequently have trouble focusing on your regular tasks and daily activities. As Dr. Carolyn Dean, author of 365 Ways to Boost Your Brain Power, states, restricting dairy consumption or foods that can cause inflammation, smoking, and alcohol, may help improve these signs and symptoms of brain fog.
Mood Changes
As soon as your brain is inflamed, you may also experience signs and symptoms of depression. This type of brain inflammation is generally associated with poor lifestyle habits. As a nutritional therapist and health coach, Christina Tsiripidou informs us that eating meals that are high in proteins or altered proteins as well as low in veggies and fats, can contribute to brain inflammation. Not getting enough sleep and stress can also make these signs and symptoms worse. �
Fatigue
When your brain has inflammation, you may not only experience brain fog but you may also experience fatigue which commonly accompanies it. According to Caleb Wellness, Health and Backe Expert for Maple Holistics, small modifications in diet and lifestyle habits can be very powerful. Besides curbing your sugar and caffeine intake, it’s important to eat foods which are full of B vitamins and fatty acids. “Besides providing you with a much-needed energy boost, these types of foods also function by minimizing inflammation, which has been linked to increased brain fog and other health issues,” Backe says. �
Headaches And Migraines
Occasionally, headaches and migraines can be caused by poor lifestyle habits, but sometimes, it may also be brought on by more serious health issues that may require immediate medical attention. By way of instance, acute headaches can be an indication of inflammation and even swelling in the brain. As Dr. Kesari says, “This is very uncommon and it is generally associated with other neurological signs and symptoms typically due to either mass lesions or illnesses.” Often times, you also can’t really tell if a headache is brought on by a much more serious health issue, so he proposes that you should ultimately consult with your healthcare professional if your headaches last more than usual and they seem unusual. �
Neck Stiffness
Another more serious sign and symptom of brain inflammation is neck stiffness. As Dr. Dean states, this too can indicate swelling in the brain. Meningitis and encephalitis, which are disorders that cause inflammation around the brain and spinal cord, are often caused by viruses or bacteria. If you’re experiencing neck stiffness accompanied by fever, along with headaches or migraines, make sure to see your healthcare professional right away as this may suggest a serious health issue. �
Nausea or Vomiting
Encephalitis may give you feelings of nausea, Dr. Dean says. The usual cause of this type of brain inflammation is a viral infection, such as the herpes simplex virus. In reality, brain inflammation due to herpes constitutes 10 percent of all cases of encephalitis in the United States annually. Other common signs and symptoms include a stiff neck, general weakness, and nausea or vomiting. Make sure to talk to your healthcare professional if you notice any of these signs and symptoms. �
Vision Problems
Healthcare professionals can test your eyes and detect early signs and symptoms of a stroke, a brain tumor, or even Alzheimer’s disease, among other health issues associated with brain inflammation. The brain and the eyes are connected. It is not surprising that when your brain has inflammation, your vision can also ultimately be influenced, Dr. Dean says. � If you’re experiencing any of these signs and symptoms, talk to your healthcare professional. According to Dr. Kesari, the treatment depends on the signs and symptoms. Brain imaging, blood work, and spinal fluid analysis may be needed based on the clinical presentation. For severe symptoms, inflammation is treated with different immunosuppressive treatments including steroids, IVIG, plasmapheresis, and Rituxan. When the source of chronic brain inflammation is lifestyle-related, adjustments to diet, working on stress and also the elimination of habits, such as smoking, may ultimately help. �
Acute and chronic brain inflammation has been associated with a variety of signs and symptoms, including depression, cognitive, and other mental health issues. Inflammation in the brain can even cause a variety of neurological diseases, such as Alzheimer’s disease. Inflammation is an essential function of the human body, however, too much inflammation, especially in the brain, can alter our overall health and wellness. Make sure to talk to your healthcare professional if you experience any unusual signs and symptoms associated with brain inflammation. – Dr. Alex Jimenez D.C., C.C.S.T. Insight
Metabolic Assessment Form
The following Metabolic Assessment Form can be filled out and presented to Dr. Alex Jimenez. Symptom groups listed on this form are not intended to be utilized as a diagnosis of any type of disease, condition, or any other type of health issue. �
In honor of Governor Abbott’s proclamation, October is Chiropractic Health Month. Learn more about the proposal. � Inflammation is the human body’s natural response to injury, infection, or illness. However, too much inflammation can affect your overall health and wellness, especially when you have inflammation in the brain. Brain inflammation can even affect your mental and emotional well-being. Inflammation in the brain is associated with neurological disorders. The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or chronic disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 . �
Curated by Dr. Alex Jimenez �
Additional Topic Discussion: Chronic Pain
Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals, however, chronic pain is different than the average type of pain. With chronic pain, the human body will continue sending pain signals to the brain, regardless if the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient’s mobility and it can reduce flexibility, strength, and endurance.
Neural Zoomer Plus for Neurological Disease
Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual�s reactivity to 48 neurological antigens with connections to a variety of neurologically related diseases. The Vibrant Neural ZoomerTM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention. �
Formulas for Methylation Support
XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly,�Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic�Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
�
For your convenience and review of the XYMOGEN products please review the following link.*XYMOGEN-Catalog-Download �
* All of the above XYMOGEN policies remain strictly in force.
Inflammatory reactions in the central nervous system (CNS) are currently known to be associated with many neurological disorders. In neurodegenerative diseases, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), there is considerable penetration of different leukocyte subsets into the CNS or there is severe activation of microglial cells which increases many inflammatory mediators in the CNS. In acute CNS disorders, including delayed corrosion associated with vasospasm after subarachnoid hemorrhage (SAH), ischemic stroke, spontaneous intracerebral hemorrhage (ICH), and traumatic brain injury (TBI), current evidence from a variety of research studies reveal that inflammation may be a possible target for treatment. Inflammation is becoming a promising region of research study for new treatments. �
To speed up the process of translating this information to clinical applications, a number of significant problems have to be addressed as their capacity to continuously identify characteristic cerebral deficits in people with neurodegenerative diseases, the connections of brain injuries to clinical symptoms and genetic diagnosis as well as the level to which the harm respond to various treatment approaches. In this article, findings that address some of these problems are reported by several researchers. �
Inflammation and Neurological Disorders
In neurodegenerative diseases, a research study reviewed the function of chronic neuroinflammation in the pathogenesis of Alzheimer’s disease (AD). With the glial fibrillary acidic protein-interleukin 6 (GFAP-IL6) transgenic mice model, the researchers demonstrated that this animal model, in which chronic neuroinflammation triggered the expression of the cytokine interleukin-6 (IL-6) in astrocytes, could serve as a great tool for drug and/or medicine discovery and validation in vivo. �
Another research study assessed the role of inflammation in the neuropathology of Parkinson’s disease (PD). They supplied a synopsis of current knowledge on the temporal profile of immune reactions in PD and discussed the potential effects of central and peripheral inflammation. The research study utilized TRODAT-1 SPECT to rate leukocyte apoptosis from PD patients and its association with central dopamine neuron loss. The leukocyte apoptosis and striatal dopamine transporter uptake ratios were associated with the duration of the disease and increased severity. The interaction between brain and systemic inflammation may be liable for the neurodegenerative disease progression. Another research study utilized the Longitudinal Health Insurance Database 2000 (LHID2000) to analyze and evaluate the probability of dementia between patients clinically diagnosed with autoimmune rheumatic diseases (ARD) and non-ARD patients during a 5-year follow-up interval. Their findings indicate that patients with and without ARD had comparable risks of developing dementia. �
In severe critical CNS diseases, the research study utilized traumatic brain injury (TBI) models to determine whether simvastatin, together with an antioxidant, could cause cerebral vascular endothelial inflammatory responses after traumatic brain injury in rat models. Their findings support that simvastatin combined with an antioxidant could offer neuroprotection and it could possibly be attributed to cerebral vascular inflammatory reactions. The analysis utilized a structural equation modeling to evaluate the predictive value of admission Glasgow Coma Scale (GCS) scores, duration of unconsciousness, neurosurgical intervention, and countercoup lesion associated with the impairment of memory and processing rate functions six months after a TBI. The analysis also revealed that admission GCS score is a tremendous predictor of memory/processing speed dysfunctions after TBI. �
One research study investigated serum thiobarbituric acid-reactive substances (TBARS) and free thiol levels in a variety of subtypes of acute ischemic stroke (AIS) where they evaluated their association with clinical results. They discovered that patients with the disease have greater oxidative stress but reduced antioxidant defense compared to those with disease following AIS. Serum TBARS level at the acute phase of a stroke is a predictor for the outcome. Along with other research studies, these aimed to ascertain whether serum adhesion molecules are associated with septic encephalopathy (SE). Their findings reveal that SE suggests higher mortality in nontraumatic patients with sepsis. Serum vascular cell adhesion molecule-1 (VCAM-1) degree on presentation is a much more effective predictor of SE in these patients than lactate concentration and other adhesion molecules on admission, according to research studies. �
From the CNS health issues, research studies investigated the relationship between protein expressions of two autophagy markers, LC3B and Beclin-1, with clinical trials in astrocytoma patients. Their results suggest that targeting the cancer stem-like cell in astrocytoma can offer an approach that astrocytoma cancer stem-like cells together with improved autophagy may lead to resistance. Along with another research study, researchers researched DAPK protein expression and promoter hypermethylation in central neurocytoma and oligodendroglioma. Their results demonstrated that repressed expression and DAPK promoter hypermethylation of DAPK protein were prevalent in central neurocytoma than in oligodendroglioma. DAPK promoter hypermethylation can be useful for differential diagnosis between these two types of tumors. �
In conclusion, the article above emphasizes several essential research strategies that are making it more evident that neuroinflammation or inflammatory reactions are of translational significance for different types of neurological disorders. The results from these research studies not only enable us to understand the pathogenesis of these disorders but these also show great potential to provide desperately objective biomarkers for analysis and clinical investigation. Knowledge and comprehension of those conditions have contributed to the development of effective treatments, animal models, and innovative tools to characterize these medical conditions and provide better treatment options to patients. �
Neuroinflammation is ultimately characterized as the inflammation of the nervous tissue. It can commonly occur due to a variety of factors, including toxins, infections, autoimmune diseases, and even traumatic brain injury (TBI). In the central nervous system (CNS), the microglial cells are in charge of activating inflammatory reactions associated with these factors. However, excess microglia activation can ultimately cause a variety of health issues, including neurological diseases, among others. – Dr. Alex Jimenez D.C., C.C.S.T. Insight
Metabolic Assessment Form
The following Metabolic Assessment Form can be filled out and presented to Dr. Alex Jimenez. Symptom groups listed on this form are not intended to be utilized as a diagnosis of any type of disease, condition, or any other type of health issue. �
In honor of Governor Abbott’s proclamation, October is Chiropractic Health Month. Learn more about the proposal. �
Inflammatory reactions in the central nervous system (CNS) are currently known to be associated with many neurodegenerative diseases, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or chronic disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 . �
Curated by Dr. Alex Jimenez
Additional Topic Discussion: Chronic Pain
Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals, however, chronic pain is different than the average type of pain. With chronic pain, the human body will continue sending pain signals to the brain, regardless if the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient’s mobility and it can reduce flexibility, strength, and endurance.
Neural Zoomer Plus for Neurological Disease
� �
Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual�s reactivity to 48 neurological antigens with connections to a variety of neurologically related diseases. The Vibrant Neural ZoomerTM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention. �
Formulas for Methylation Support
XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly,�Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic�Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
�
For your convenience and review of the XYMOGEN products please review the following link.*XYMOGEN-Catalog-Download �
* All of the above XYMOGEN policies remain strictly in force.
There is plenty of controversies associated with MSG. Researchers believe that the excess consumption of monosodium glutamate can cause asthma, headaches, and even brain health issues. On the other hand, the majority of official sources, including the FDA, claim that MSG is a safe food ingredient. The following article discusses what is monosodium glutamate, or MSG, and its effects on overall health and wellness, exploring both sides of the argument on the food ingredient. �
What is Monosodium Glutamate (MSG)?
MSG is known as monosodium glutamate. It is a common food ingredient that is utilized to enhance flavor in foods. MSG comes from the amino acid, glutamate or glutamic acid, which is one of the most common amino acids found in nature. Glutamate is a non-essential amino acid, which ultimately means that the human body can naturally produce it. Monosodium glutamate also serves a variety of functions in the human body and it is commonly found in almost all types of foods. �
MSG is a white crystalline powder that looks similar to sugar or table salt. It is also made up of a combination of sodium and glutamic acid, known as sodium salt. The glutamic acid in MSG is created by fermenting starches, however, there is no chemical difference between the glutamic acid in monosodium glutamate and that found in natural foods. The glutamic acid in MSG can be easier to absorb because it isn’t bound inside big protein molecules which the body breaks down. �
Glutamate in the Human Body
Our stomach and gut lining have many glutamate receptors. MSG and other types of glutamate are absorbed through these receptors. Once in the gastrointestinal, or GI, tract, glutamate is broken down as energy or incorporated into other molecules. Glutamate is also an essential neurotransmitter in the brain. However, researchers believe that dietary glutamate is unable to cross the blood-brain barrier, which ultimately suggests that all glutamate from the brain is created there. �
Evidence from research studies in mice showed that the blood-brain barrier in newborns is immature and that glutamate can pass into the brain. Increased levels of glutamate injected into newborn mice caused considerable brain damage. A research study showed that increased levels of MSG also cause severe effects in fruit flies, causing premature death. While the levels utilized in these research studies exceeded average daily consumption reported among humans, it is essential to mention that restaurants and food manufacturers are not required to declare the levels of MSG added to their foods. �
Is MSG Good or Bad for You?
Glutamate, or glutamic acid, functions as a neurotransmitter in the human brain. It is also considered an excitatory neurotransmitter, which means that it stimulates nerve cells to transmit signals. Several people believe that MSG causes excess glutamate in the brain and excess stimulation of the nerve cells. Therefore, MSG has been labeled as an excitotoxin. �
Concerns associated with the effects of MSG date as far back as 1969, when a research study found that injecting large doses of MSG into newborn mice caused harmful neurological effects. Since then, a variety of other sources have continued to have this concern with MSG. Another research study showed that increased glutamate activity in the brain can cause harm and large doses of MSG can raise blood levels of glutamate. Aa megadose of MSG increased blood levels by 556%. �
However, dietary glutamate should have little to no effect on the human brain because it can’t cross the blood-brain barrier in large amounts. There is not enough evidence to show that MSG acts as an excitotoxin when consumed in normal amounts. �
Monosodium Glutamate (MSG) Sensitivity
Several people may also experience adverse effects from consuming MSG. This health issue is known as Chinese restaurant syndrome or MSG symptom complex. In one research study, people with self-reported MSG sensitivity consumed either 5 grams of MSG or a placebo where 36.1% reported reactions with MSG compared to 24.6% with placebo. Common symptoms included headaches, flushing, muscle tightness, tingling sensations, numbness, and weakness, among other symptoms. �
The threshold dose that causes symptoms seems to be around 3 grams per meal. However, keep in mind that 3 grams is a very high dose, approximately six times the average daily intake of MSG in the United States. It is still unclear why this happens, however, some researchers hypothesize that such large doses of MSG allow trace amounts of glutamic acid to cross the blood-brain barrier and interact with neurons which can cause brain damage, swelling, and injury. Several believe that MSG also causes asthma in susceptible people. In one 32-person research study, 40% of participants experienced an asthma attack with MSG. However, other research studies did not find any relationship between MSG intake and asthma. �
Conclusion
Depending on who you ask, MSG is either perfectly safe or a dangerous neurotoxin. The truth lies somewhere in between. Evidence indicates that MSG is safe in moderate amounts. However, megadoses may cause harm. If you react adversely to MSG, you shouldn�t eat it. That said, if you don�t experience side effects, there�s no compelling reason to avoid it. Keep in mind that MSG is generally found in processed, low-quality foods � which you should avoid or limit anyway. If you already eat a balanced diet with plenty of whole foods, you shouldn�t have to worry about high MSG intake. �
The controversy between MSG and brain health has been determined by a variety of research studies. Monosodium glutamate, or MSG, has been utilized as a food ingredient and it is largely consumed by many people in the US on a regular basis today. Although the FDA, or the Food and Drug Administration, categorizes MSG as a safe food ingredient, many research studies have determined that it can cause a variety of brain health issues, including neurological diseases, among other well-known health issues. – Dr. Alex Jimenez D.C., C.C.S.T. Insight
Metabolic Assessment Form
The following Metabolic Assessment Form can be filled out and presented to Dr. Alex Jimenez. Symptom groups listed on this form are not intended to be utilized as a diagnosis of any type of disease, condition, or any other type of health issue. �
In honor of Governor Abbott’s proclamation, October is Chiropractic Health Month. Learn more about the proposal. � There is plenty of controversies associated with MSG. Researchers believe that the excess consumption of monosodium glutamate can cause asthma, headaches, and even brain health issues. On the other hand, the majority of official sources, including the FDA, claim that MSG is a safe food ingredient. The article discusses what is monosodium glutamate, or MSG, and its effects on overall health and wellness, exploring both sides of the argument on the food ingredient. The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or chronic disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 . �
Curated by Dr. Alex Jimenez �
Additional Topic Discussion: Chronic Pain
Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals, however, chronic pain is different than the average type of pain. With chronic pain, the human body will continue sending pain signals to the brain, regardless if the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient’s mobility and it can reduce flexibility, strength, and endurance.
Neural Zoomer Plus for Neurological Disease
Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual�s reactivity to 48 neurological antigens with connections to a variety of neurologically related diseases. The Vibrant Neural ZoomerTM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention. �
Formulas for Methylation Support
XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly,�Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic�Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
�
For your convenience and review of the XYMOGEN products please review the following link.*XYMOGEN-Catalog-Download �
* All of the above XYMOGEN policies remain strictly in force.
MSG is a food additive which is found in the majority of the industrial foods. It boosts the taste of the food hence attracting customers. There is no value in terms of nutrition and it really does nothing to the eater, however, it can have many effects on foods. MSG is known as an “excitotoxin” or neurotoxin. Research studies have found that it has devastating and degenerative effects on the brain and the nervous system. The neurons or brain cells overstimulate and fatigue to their death. MSG enters the brain through the membranes in the mouth and the throat. It also enters the blood-stream through the digestion of food in the gastrointestinal (GI) tract. MSG “tricks” the human body into believing that it is getting value from these foods. �
MSG is not a natural substance found in nature. It’s a man-made chemical from glutamic acid, an amino acid found in proteins. Amino acids do happen naturally in animal cells and in several plant cells. The kinds of amino acids have been processed through the change of this pure form of glutamate. Some of the materials used for this purpose include starches, molasses, and corn. The manipulation procedure generates this type of glutamate. The d-glutamate is not found naturally. The free glutamates can enter the body about eight to ten times faster compared to natural glutamates. Natural glutamate is found in foods such as tomatoes, mushrooms, and milk. Techniques used to manufacture glutamate were not in use before the 1960s. The MSG in use now is not natural. In the article, we will discuss how MSG is associated with neurological diseases. �
Research Studies on MSG and Neurological Diseases
Research studies indicate that MSG is the reason for neurological diseases like Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, and Amyotrophic lateral sclerosis. Neuroscientists have explained that MSG attacks the blood-brain barrier of the neurons which is responsible for the regulation of the fragile chemical exchange inside the brain cells. The chemical exchange process is well balanced and its performance is unquestionable. Under normal conditions, the brain and the entire immune system manage all sorts of toxins, health issues, and stress. A very small amount of poisonous substances can actually make the brain overreact, ultimately resulting in excessive exhaustion and death, according to research studies. �
MSG is a leading “excitotoxin” and it is widely known to cause harm to the brain region which governs or controls additional systems from the human body. The damage will seem like a disease in the endocrine system and the immune system. This can be shown in the cases of food cravings, persistent hunger, and unusual sleeping patterns. This normally leads to obesity. MSG is also known to cause migraine headaches, behavioral disorders, depression, asthma attacks, heart problems, arthritis, sinus issues, and digestive issues. �
MSG is a neurotoxin which requires an extremely brief time to create a broadly diverse and dramatic effect on the human body. An individual may have a mild dose of a prescription drug and also have favorable effects. However, another individual might take the prescription drug and get sad, have a swollen tongue, stomach disorders, and joint problems. The different parts of the brain affected do govern various body functions. The part which is attacked will depend on the individual. If by way of instance, an individual has had a headache, a genetic pinch in a given portion of the brain, has had a fever that’s attacking regions of the brain, or has had a stroke, then it’s certain that the component of the brain that has been affected will be due to the toxins. �
A number of the foods sold are ultimately sold as weight loss promotions to the people. MSG, along with aspartame, is added when food substances, such as fat and sugar, are eliminated from the meals. These excitotoxins have been known to cause obesity and irregular heartbeats. FDA generally allows the labeling of MSG’S as natural flavors, hydrolyzed proteins, and autolyzed yeast, when used as just a partial ingredient in an additive rather than only MSG. Americans now are consuming 160 million lbs of MSG per year. Author and toxicologist Dr, George Schwartz asserts that two tablespoons of MSG on bread could kill a medium-sized dog within a moment. The FDA in 1995 claimed that no one can respond to less than 3 grams of MSG per meal. In spite of their confirmation, they’ve warned that children, pregnant or lactating women, and the elderly should avoid MSG. An extremely sensitive individual can also ultimately react even to under a gram of MSG. �
Effects of MSG and Neurological Diseases
Research studies have shown that from the late 1950s, an estimated amount of 12 grams per person of MSG was utilized by most Americans each year. These days, taking a look at precisely the same health issue, the quote is between 400 and 500 g per person each year. This is an amount which requires evaluation. The wide usage of MSG arrived in the mid-1970s. It gained much popularity throughout the 1980s with manufacturers of food. Two powerful excitotoxic food additives which took the food sector by storm have been the use of MSG and aspartame. MSG has been broadly associated with a wide assortment of symptoms and health issues. As previously stated, it affects the human body’s neurological system. The same ailments are being reported to be on their rise. The ailments are absolutely unexpected and difficult to describe. �
Neurological diseases associated with MSG and numbers of interest released by federal organizations have been recorded in fibromyalgia, which is a growing epidemic. Its patients eliminated aspartame and MSG during the research study conducted by the Florida University which reported complete relief of symptoms. On the other hand, the most cognitive research study was conducted to prove the connection between fibromyalgia and MSG along with several different additives as a common rheumatologic disorder. In this case, 4 patients had been diagnosed for 2 to 17 years with fibromyalgia syndrome. They had undergone various methods of therapy whilst failing to consider MSG as the causative agent. After eliminating aspartame and MSG in their diets, complete or near complete resolution of symptoms diagnosed was listed within months. The subjects were women who had recurring symptoms and multiple comorbidities. It’s therefore indicative that the excitotoxins, present in compounds, such as aspartate and MSG, become excitatory neurotransmitters once ingested and when consumed in excess may lead to neurotoxicity. These 4 patients may, therefore, signify this fibromyalgia syndrome and act as a link to conclusively establish a link to MSG. Therefore, persistent research studies, if carried out on a larger sample, might serve to connect the fibromyalgia syndrome into MSG and aspartame more concretely. Further research studies are required. �
Moreover, a research study connected MSG to adrenal adenomas. The hypothalamus which leads damage on the nerves is overstimulated by MSG. The hypothalamus is responsible for directing the pituitary gland’s actions, which can be known as the endocrine gland since it in turn directs the rest of the glands in the human body and their activities such as metabolism, development of reproductive and sex organs and other essential development functions. Statistics have demonstrated that 25 percent of Kenyans have a pituitary adenoma. However, research studies linking pituitary adenomas to MSG have ultimately been inconclusive. Some research studies had depicted this as a disease but have been proven wrong. �
About half of the pituitary adenomas secrete prolactin. These can become large over time in the optic nerve, thus, affecting vision. It also prevents ovulation and menses. This prevents pregnancy or conception generally. Furthermore, since prolactin is responsible for lactation, lactation can be caused by secretion in the individual even if they’re male or even when they were not pregnant. Men with these adenomas grow breasts. Since the tumor can only be discovered when it’s big and dangerous unlike in women that are forewarned by the effects on vision or related headaches, this problem is deadly in men. There’s a further need to sponsor more research studies so as to ultimately associate MSG and brain tumors, among others. �
Other effects which were attributed to MSG and neurological diseases are headaches and migraines, asthma, and obesity amongst others. In headaches and migraines, an approximate amount of $2.2 billion each year are being spent on drugs and/or medicines that treat head pain. This chronic condition has received a 74 percent increase. Second, asthma associated with the brain was connected to MSG. According to data, there was a decrease of asthma before the mid-eighties. Since then, however, there’s been a 100 percent gain in the rate of death among children and seniors. This prevalence has increased by 600 percent in the last 10 years. FDA has identified that uncontrollable asthma can be caused by MSG, sadly, no measures are taken to take care of the situation. In defects of birth and disorders of production, MSG was identified as a mutagen i.e. mutates fetuses. It’s reputed to cause damage to the development, reproduction, and growth patterns as well as the functions. Such research studies have not been concrete. Other consequences include emotional or neurological disorders. Laboratory research studies demonstrate devastating effects on brain development, including dyslexia, attention deficit, autism, hyperactivity, violent episodes or rage, panic attacks, depression, paranoia, seizures and cerebral palsy. Rats were utilized with this research study. However, human beings are five times more sensitive to MSG than rats. �
This topic of ailments in behavior for children is becoming a frequent discussion amongst professionals. These have associated attention deficits, behaviour, and instability to chemical imbalances occurring in the brain. It is now becoming an intense possibility that there’ll be damage caused by excitotoxins in the blood-brain barrier of young brains. �
In April 1994, a magazine article confirmed the rising problem of behavioral disorders. The magazine stated that the attention deficit hyperactivity disorder wasn’t in existence. It’s however said that it is currently affecting 3.3 million American kids. This magazine article estimates prominent research studies which 10 years ago stated that symptoms of ADHD and ADD vanished with maturity. Nowadays, however, ADD is the fastest growing diagnostic category for adults. The combination of both excitotoxins i.e. MSG and aspartame came into wide utilization in the 1980s. �
In the medical field, a controversy as to whether MSG is associated with neurological diseases has been determined. Monosodium glutamate, or MSG, has been utilized as a flavorant in the food industry for approximately 100 years and it is consumed by the masses on a regular basis today. Although the FDA, or the Food and Drug Administration, categorizes MSG as a safe food ingredient, many research studies have determined that it can cause a variety of health issues, including neurodegenerative diseases, among others. – Dr. Alex Jimenez D.C., C.C.S.T. Insight – Dr. Alex Jimenez D.C., C.C.S.T. Insight
Metabolic Assessment Form
The following Metabolic Assessment Form can be filled out and presented to Dr. Alex Jimenez. Symptom groups listed on this form are not intended to be utilized as a diagnosis of any type of disease, condition, or any other type of health issue. �
In honor of Governor Abbott’s proclamation, October is Chiropractic Health Month. Learn more about the proposal. � MSG is a food additive. It boosts the taste of food, attracting customers. There is no nutrition and it really does nothing to the eater, however, it can have many effects on foods. MSG is known as an “excitotoxin” or neurotoxin. Research studies have found that it has devastating and degenerative effects on the brain and the nervous system. The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or chronic disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 . �
Curated by Dr. Alex Jimenez �
Additional Topic Discussion: Chronic Pain
Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals, however, chronic pain is different than the average type of pain. With chronic pain, the human body will continue sending pain signals to the brain, regardless if the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient’s mobility and it can reduce flexibility, strength, and endurance.
Neural Zoomer Plus for Neurological Disease
� �
Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual�s reactivity to 48 neurological antigens with connections to a variety of neurologically related diseases. The Vibrant Neural ZoomerTM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention. �
Formulas for Methylation Support
XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly,�Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic�Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
�
For your convenience and review of the XYMOGEN products please review the following link.*XYMOGEN-Catalog-Download �
* All of the above XYMOGEN policies remain strictly in force.
When compared to other central nervous system (CNS) health issues, chronic neurodegenerative diseases can be far more complicated. Foremostly, because the compromised mitochondrial function has been demonstrated in many neurodegenerative diseases, the resulting problems in energy sources are not as severe as the energy collapse in ischemic stroke. Therefore, if excitotoxicity contributes to neurodegeneration, a different time of chronic excitotoxicity needs to be assumed. In the following article, we will outline what is known about the pathways that may cause excitotoxicity in neurodegenerative diseases. We will specifically discuss that in amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD) and Huntington’s disease (HD) as fundamental examples with sufficiently validated animal models in research studies. �
Huntington’s Disease
Huntington’s disease (HD) is as an inherited, fatal neurodegenerative disease which is caused by a trinucleotide (CAG) repeat expansion in the coding region of the huntingtin (htt) gene which is associated with the degeneration of the GABAergic medium-sized spiny neurons (MSN) in the striatum, although other brain regions can also ultimately be affected as the health issue progresses. HD is identified as a movement disorder with co-morbid cognitive and psychiatric symptomatology. Both mutant htt RNA together with the encoded protein which includes a polyglutamine repeat expansion is believed to cause the complicated changes in cellular metabolism which occurs in mitochondrial dysfunction and oxidative stress. �
Early research study findings which demonstrated that excitotoxicity may play a fundamental role in HD were based upon the observation that an injection of their KYN metabolite and NMDA receptor agonist QUIN, in addition to L-glutamate and kainate, in the striatum of rats caused neuronal degeneration. Another research study determined that QUIN, as compared to NMDA and kainate, causes selective degeneration of the MSNs instead of neuronal death, which tremendously resembles the pathology of HD. Moreover, NMDA receptors have been shown to be hyperactive and striatal neurons from different HD mouse models, such as a yeast artificial chromosome (YAC) which leads to over-expression of full-length htt with elongated polyglutamine repeats as well as R6/2 mice over-expressing htt exon 1 with elongated polyglutamine repeats in addition to in knock-in mice with greater CAG repeats inserted from the mouse htt gene, were demonstrated to be sensitized to excitotoxicity in vitro. Furthermore, in vivo, a sensitization to an excitotoxin injection into the striatum was only demonstrated in the transgenic YAC model of HD, whereas mice overexpressing mutant htt exon 1, R6/1 and R6/2 mice, or N171-82Q mice overexpressing mutant exon 1 and components of exon 2 or the so-called “shortstop” mouse expressing human N-terminal htt encoded by exon 1 and 2 with a 128 CAG repeat below the htt promoter, produced somewhat of a resistance to striatal excitotoxin injection during the aging process. This neuroprotection isn’t necessarily for NMDA receptor agonists, however, it can help different neurotoxic insults and may be an adaptive response to cellular stress. �
Rat MSN release increased levels of NR2A- and NR2B-containing NMDA receptors compared to interneurons in the striatum. NR1 and NR2B mRNA expression in the neostriatum of HD patients has been demonstrated to considerably decrease which is associated with the loss of these neurons. In addition, NMDA receptor-mediated pathways in MSN were determined to be tremendously sensitive to the NR2B-specific inhibitor ifenprodil. In HEK293 cells, overexpression of mutant htt increased NMDA receptor-mediated pathways and aggravated NMDA-induced cell release only when NR2B- but not when NR2A-containing NMDA receptors were co-expressed. One possible explanation for the increase in NR2B-containing NMDA receptor expression from HD models is that an extended polyglutamine repeat in htt decreases its connection to PSD95, a postsynaptic density protein included in NMDA and kainate receptor clustering, ultimately causing a greater response of PSD95 together with the NR2B subunit. Recently, research study findings suggest that not only does the subunit composition but also the localization of NMDA receptors may play a fundamental role in the NMDA receptor activity. Another research study showed that in severe striatal slice preparations from YAC transgenic mice utilizing 128 CAG repeats, extrasynaptic NMDA receptors, especially those with NR2B, are considerably increased compared to pieces from wild-type mice and YAC mice expressing htt with 18 CAG repeats. As expected from in vitro research studies, this change was associated with decreased CREB phosphorylation. The increased percentage of NR2B-containing extrasynaptic NMDA receptors was demonstrated to be associated with increased extrasynaptic localization of PSD95. One pathway which may cause the sensitization to excitotoxic stimulation downstream of the activation of extrasynaptic NMDA receptors was identified as activation of p38 MAPK. Taken multilayered evidence suggests that mutant htt results in sensitization of MSN into glutamate excitotoxicity through the redistribution of NMDA receptors from subunits to extrasynaptic sites. �
The activation of extrasynaptic NMDA receptors in acute striatal brain slices can be effectively shown in YAC mice utilizing 128 CAG repeats through spillover of synaptic glutamate by restricting EAATs. As a result, it may be determined that decreased EAAT expression may increase the activation of NMDA receptors. Surprisingly, within situ-hybridization, research studies discovered a decrease in astrocytic EAAT2 mRNA expression in the neostriatum of all HD patients. As compared to wild-type mice, however, no changes in protein expression were found to be decreased in synaptosomes of YAC mice overexpressing human htt utilizing 128 CAG repeats. The researchers determined that a decrease in EAAT2 activity from the YAC model of HD was caused by decreased palmitoylation of the transporter. In R6/2 mice, others discovered decreased EAAT2 mRNA and protein expression associated with decreased EAAT2 in synaptosomes or acute cortico-striatal pieces. However, extracellular striatal glutamate concentrations have been shown to be similar to those of wild-type control mice and a decreased glutamate clearance capability in the R6/2 mice demonstrated by therapy with EAAT inhibitors or glutamate. A putative explanation for this finding could be a decrease in glutamate release through system x?c and in xCT, the subunit of system x?c which has been demonstrated at the striatum of R6/2 mice in the mRNA and protein levels. �
As previously mentioned, the injection of the KYN metabolite QUIN in supraphysiological concentrations was utilized as an early animal model of HD. This caused further research studies of KYN metabolism in HD. Surprisingly, the QUIN precursor 3HK aggravates neurodegeneration from the QUIN HD version while KYNA is protective. Research studies discovered that in early-stage HD, compared to control and end-stage HD, neostriatal 3HK and QUIN concentrations were considerably upregulated. Another research study discovered that KYNA levels decreased in autopsied HD striata with the CSF of HD patients when compared with controls. The first enzyme of this KYN pathway, IDO, is triggered from the striatum of both YAC mice with 128 CAG repeats. Mice deficient in IDO are less sensitive to intrastriatal QUIN injection. Evaluation of KYN metabolites from three different mouse models of HD, R6/2 mice, YAC128 mice as well as HdhQ92 and HdhQ111 knock-in mice in various brain regions, suggested age-dependent activation of their KYN pathway. However, the detailed pattern of metabolite changes was different among the versions with increased 3HK in cortex, striatum, and cerebellum in R6/2 mice whereas mice expressing full-size mutant htt demonstrated an extra cortical and striatal upregulation of QUIN. Moreover, treatment of R6/2 mice with a non-blood brain barrier permeable KMO inhibitor, JM6, which indirectly improved cerebral extracellular KYNA concentrations by 50 percent, has been associated with a decrease in extracellular cerebral L-glutamate, decreased neurodegeneration and prolonged survival. Further research studies are still required for further evidence. �
Taken collectively, the research studies support the view that in HD there is a redistribution of both NMDA receptors, especially those containing NR2B, which can activate signaling pathways which boost neurodegeneration, as shown in Figure 5. There is not any evidence that cerebral L-glutamate levels are grossly increased in HD. This might be explained by the fact that even though EAAT2 and KYNA may be downregulated, there is also a downregulation of system x?c action. As only very high levels of QUIN activated NMDA receptors, this KYN metabolite is unlikely to contribute to the excitotoxic load. �
In many research studies, evidence and outcome measures have demonstrated that glutamate dysregulation and excitotoxicity in many neurological diseases, including AD, HD, and ALS, ultimately lead to neurodegeneration and a variery of symptoms associated with the health issues. The purpose of the following article is to discuss and demonstrate the role that glutamate dysregulation and excitotoxicity plays on neurodegenerative diseases. The mechanisms for excitotoxicity are different for every health issue. – Dr. Alex Jimenez D.C., C.C.S.T. Insight – Dr. Alex Jimenez D.C., C.C.S.T. Insight
Metabolic Assessment Form
[wp-embedder-pack width=”100%” height=”1050px” download=”all” download-text=”” attachment_id=”72423″ /] � The following Metabolic Assessment Form can be filled out and presented to Dr. Alex Jimenez. Symptom groups listed on this form are not intended to be utilized as a diagnosis of any type of disease, condition, or any other type of health issue. �
In honor of Governor Abbott’s proclamation, October is Chiropractic Health Month. Learn more about the proposal. �
In the article above, we outlined what is known about the pathways which may cause excitotoxicity in neurodegenerative diseases. We also discussed that in amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD) and Huntington’s disease (HD) as fundamental examples with sufficiently validated animal models in research studies. The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or chronic disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 . �
Curated by Dr. Alex Jimenez �
References
Lewerenz, Jan, and Pamela Maher. �Chronic Glutamate Toxicity in Neurodegenerative Diseases-What Is the Evidence?� Frontiers in Neuroscience, Frontiers Media S.A., 16 Dec. 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC4679930/.
Additional Topic Discussion: Chronic Pain
Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals, however, chronic pain is different than the average type of pain. With chronic pain, the human body will continue sending pain signals to the brain, regardless if the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient’s mobility and it can reduce flexibility, strength, and endurance.
Neural Zoomer Plus for Neurological Disease
Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual�s reactivity to 48 neurological antigens with connections to a variety of neurologically related diseases. The Vibrant Neural ZoomerTM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention. �
Formulas for Methylation Support
XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly,�Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic�Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
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For your convenience and review of the XYMOGEN products please review the following link.*XYMOGEN-Catalog-Download �
* All of the above XYMOGEN policies remain strictly in force.
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