Dr. Alex Jimenez Explains How Inflammation and Oxidative Stress Affects Methylation
DNA methylation activity is in charge of a variety of essential bodily functions, however, this process can be easily interrupted. According to healthcare professionals, proper nutrition and lifestyle habits can help decrease inflammation and oxidative stress which can affect methylation. Although a complete research study on the treatments which can help reduce inflammation and oxidative stress is beyond the scope of this article, the following list offers common treatments utilized to help promote methylation support.
Inflammation
Regulating blood glucose levels can help manage inflammation in the human body. Increased circulating glucose levels as well as acute, postprandial glucose spikes can ultimately trigger oxidative stress, demonstrating that glucose should be controlled. Excess weight can also develop pro-inflammatory cytokines, including TNF-alpha and IL-6, which has been associated with abnormal DNA methylation patterns. An increased body-mass index, or BMI, and especially central adiposity, can ultimately trigger chronic inflammation.
Excessive levels of bacteria or dysbiosis in an individual’s gastrointestinal, or GI, tract can also promote higher levels of local and systemic inflammation. Bacterial pro-inflammatory compounds with systemic effects can originate from both the small and large intestine as well as in the stomach and oral cavity. Pro-inflammatory pathogenic bacterial species may also be found in internal tissues, such as atherosclerotic plaque. Helicobacter pylori, potentially located in the stomach, is also associated with abnormal methylation.
Food allergies and food sensitivities have also been demonstrated to increase inflammation through innate immune activation. Follow an anti-inflammatory diet which avoids the consumption of pro-inflammatory foods, such as sugars, refined carbohydrates, conventionally-raised animal products, refined vegetable oils, hydrogenated fats, and phytonutrient-rich whole plant foods and omega-3 fatty acids. Furthermore, pro-inflammatory lifestyle factors, such as stress and sedentary behavior, can be regulated through stress management techniques and physical activity. Lifestyle factors also affect DNA methylation, inflammation, and oxidative stress.
Oxidative Stress
Oxidative stress can be caused due to metabolic, dietary or environmental factors, including excessive calories, excessive sugars/refined carbohydrates, too little or too much exercise, excessive alcohol consumption, tobacco smoke, air pollutants, fungal toxins, charbroiled foods and other advanced glycation end products, ionizing radiation, chronic infections, poor sleep, and gut dysbiosis, can all contribute to oxidative stress which may lead to inflammation and affect DNA methylation activity.
Regulating oxidative stress, and therefore inflammation and DNA methylation activity, includes decreasing pro-inflammatory sources as well as increasing support in the form of antioxidants found in a high plant-food diet, herbs, spices, nuts, seeds, and unrefined oils. Specific supplements such as N-acetylcysteine, alpha lipoic acid and coenzyme Q10 may also be useful. The process by which oxidative stress can lead to inflammation and affect methylation is demonstrated by a variety of processes in the diagram below.
Inflammation is the human body’s natural response to injury, infection, or disease. Although it plays a fundamental role by signaling the immune system to heal and repair damaged tissue as well as to defend itself against foreign invaders, chronic inflammation caused by oxidative stress can affect DNA methylation. As mentioned in the article above, proper nutrition and lifestyle habits can help reduce inflammation caused by oxidative stress, ultimately improving methylation and overall health and wellness.
Dr. Alex Jimenez D.C., C.C.S.T. Insight
Smoothies and Juices for Methylation Support
While many healthcare professionals can recommend nutritional guidelines and lifestyle modifications to improve methylation support, there are several options you can try yourself at home. As described above, methylation support supplementation should be determined by a healthcare professional. Smoothies and juices are a fast and easy way to include all the necessary nutrients you need for methylation support without any side-effects. The smoothies and juices below are part of the Methylation Diet Food Plan.
Sea Green Smoothie Servings: 1 Cook time: 5-10 minutes � 1/2 cup cantaloupe, cubed � 1/2 banana � 1 handful of kale or spinach � 1 handful of Swiss chard � 1/4 avocado � 2 teaspoons spirulina powder � 1 cup water � 3 or more ice cubes Blend all ingredients in a high-speed blender until completely smooth and enjoy!
Berry Bliss Smoothie Servings: 1 Cook time: 5-10 minutes � 1/2 cup blueberries (fresh or frozen, preferably wild) � 1 medium carrot, roughly chopped � 1 tablespoon ground flaxseed or chia seed � 1 tablespoons almonds � Water (to desired consistency) � Ice cubes (optional, may omit if using frozen blueberries) Blend all ingredients in a high-speed blender until smooth and creamy. Best served immediately!
Sweet and Spicy Juice Servings: 1 Cook time: 5-10 minutes � 1 cup honeydew melons � 3 cups spinach, rinsed � 3 cups Swiss chard, rinsed � 1 bunch cilantro (leaves and stems), rinsed � 1-inch knob of ginger, rinsed, peeled and chopped � 2-3 knobs whole turmeric root (optional), rinsed, peeled and chopped Juice all ingredients in a high-quality juicer. Best served immediately!
Ginger Greens Juice Servings: 1 Cook time: 5-10 minutes � 1 cup pineapple cubes � 1 apple, sliced � 1-inch knob of ginger, rinsed, peeled and chopped � 3 cups kale, rinsed and roughly chopped or ripped � 5 cups Swiss chard, rinsed and roughly chopped or ripped Juice all ingredients in a high-quality juicer. Best served immediately!
Zesty Beet Juice Servings: 1 Cook time: 5-10 minutes � 1 grapefruit, peeled and sliced � 1 apple, washed and sliced � 1 whole beet, and leaves if you have them, washed and sliced � 1-inch knob of ginger, rinsed, peeled and chopped Juice all ingredients in a high-quality juicer. Best served immediately!
Protein Power Smoothie Serving: 1 Cook time: 5 minutes � 1 scoop protein powder � 1 tablespoon ground flaxseed � 1/2 banana � 1 kiwi, peeled � 1/2 teaspoon cinnamon � Pinch of cardamom � Non-dairy milk or water, enough to achieve desired consistency Blend all ingredients in a high-powered blender until completely smooth. Best served immediately!
ProLon� Fasting Mimicking Diet
Balanced methylation support can be achieved through proper nutrition. The ProLon� fasting mimicking diet offers a 5-day meal program which has been individually packed and labeled to serve the foods you need for the FMD in precise quantities and combinations. The meal program is made up of ready-to-eat or easy-to-prepare, plant-based foods, including bars, soups, snacks, supplements, a drink concentrate, and teas. The products are scientifically formulated and great tasting. Before starting the ProLon� fasting mimicking diet, 5-day meal program, please make sure to talk to a healthcare professional to find out if the FMD is right for you. The ProLon� fasting mimicking diet can help promote methylation support, among a variety of other healthy benefits.
Many healthcare professionals recommend a variety of treatment options to help regulate oxidate stress and inflammation to prevent health issues associated with DNA methylation. Proper nutrition and lifestyle habits, can improve methylation. The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .
Curated by Dr. Alex Jimenez
Additional Topic Discussion: Acute Back Pain
Back pain is one of the most prevalent causes of disability and missed days at work worldwide. Back pain attributes to the second most common reason for doctor office visits, outnumbered only by upper-respiratory infections. Approximately 80 percent of the population will experience back pain at least once throughout their life. Your spine is a complex structure made up of bones, joints, ligaments, and muscles, among other soft tissues. Injuries and/or aggravated conditions, such as herniated discs, can eventually lead to symptoms of back pain. Sports injuries or automobile accident injuries are often the most frequent cause of back pain, however, sometimes the simplest of movements can have painful results. Fortunately, alternative treatment options, such as chiropractic care, can help ease back pain through the use of spinal adjustments and manual manipulations, ultimately improving pain relief.
Formulas for Methylation Support
XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly, Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
For your convenience and review of the XYMOGEN products please review the following link.*XYMOGEN-Catalog-Download
* All the above XYMOGEN policies remain strictly in force.
Research has given us even more reasons to eat our veggies. Several studies have revealed that certain types of vegetables, specifically those known as cruciferous vegetables, have properties that could make them useful in preventing cancer.
Contents
What are Cruciferous Vegetables?
Some of the crunchiest, tastiest vegetables belong to the Cruciferae family. Typically cool weather vegetables, they are most notably characterized by four petal flowers somewhat resembling a cross.
These flower buds or the leaves are the parts of these plants that are most often consumed. However, the seeds or roots of some of these vegetables are also edible. Incorporating some of these cruciferous vegetables into your diet may help lower your risk for cancer:
Broccoli
Cabbage
Wasabi
Collard greens
Bok choi
Brussels sprout
Arugula
Cauliflower
Mustard (leaves and seeds)
Turnips
Horseradish
Rutabaga
Kale
Radish
Watercress
What is the Link Between Cruciferous Vegetables and Cancer?
Cruciferous vegetables are packed with nutrients that are believed to lower a person�s risk for several types of cancers, including prostate cancer, colorectal cancer, lung cancer, and breast cancer. This includes the carotenoids zeaxanthin, lutein, and beta-carotene as well as folate and vitamins C, E, and K. They are also rich in minerals and an excellent source of fiber which is well known for preventing colorectal cancer.
This group of vegetables is also a good dietary source of glucosinolates which also has cancer-fighting properties. When intact, the glucosinolates are not effective, but when they are broken down through chewing, processing, and pests, they then make contact with the myrosinase enzyme and initiate a process that releases specific chemicals that can prevent cancer.
How Cruciferous Vegetables Prevent Cancer
There are three primary ways that cruciferous vegetables can prevent cancer. Researchers have found substantial evidence that shows when they are part of a healthy, clean, low-fat diet, a person�s risk of cancer can be decreased.
Glucosinolates � These are chemicals that contain sulfur and are present in all cruciferous vegetables, giving them their trademark bitter flavor and pungent aroma. When this substance is broken down by chewing, preparation, or digestion, it forms certain compounds (indole-3-carbinol and sulforaphane) that scientists have identified as having �anticancer properties.� They do this by impeding the development or growth of cancer. Studies have looked at this effect on mice and rats and found that it is particularly useful in specific organs. Researchers are also looking at other ways the substances can prevent cancer. When working in the body, they:
Have anti-inflammatory properties
Aid in preventing DNA damage to cells
Inhibit the formation of blood vessels in tumors
Are antibacterial and antiviral
Inhibit the migration of tumor cells, thus halting metastasis
Cause cancerous cells to die
Aid in causing carcinogens to become inactiveBioactive components � Some studies have shown that the bioactive components of these veggies can affect the biomarkers of processes related to cancer in the human body such as decreasing abnormal cell growth. Genetic encoding of glutathione S-transferase � Glutathione S-transferase is an enzyme that helps the body metabolize and eliminate isothiocyanates. This is important because isothiocyanates prevent the activation of carcinogens, increase the speed at which the carcinogens are removed from the body, and counteract the dangerous effects of active carcinogens.
Best Ways to Consume Cruciferous Vegetables
Cruciferous vegetables are at their most nutritious and have the greatest cancer-fighting properties when they are raw. When the vegetables are chopped and chewed they release the most cancer-fighting chemicals. Likewise, when they are cooked, they lose a great deal of those properties. Steaming or cooking the vegetables very lightly for less than 5 minutes will allow them to retain some of those cancer-fighting properties.
Patients from all around, each with a variety of occupations experience common painful symptoms affecting their health and wellness and quality of life. Every testimonial describes how neck pain, back pain, and piriformis syndrome, can tremendously limit their ability to engage in everyday responsibilities.
Dr. Alex Jimenez, a doctor of chiropractic, has helped them find relief from their symptoms. Each patient describes their rehabilitation, and they highly recommend Dr. Jimenez as the non-surgical choice.
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The spinal cord and brain make up the central nervous system while the spinal nerves that branch to the spinal cord and cranial nerves that branch to the brain makes up the peripheral nervous system.
There are thirty-one sets of nerves that extend out of the spinal cord and are connected to it by the nerve root. Each nerve branches out about a half inch from the spinal cord before dividing into smaller branches. The dorsal rami are on the posterior side of the branch while the larger ventral rami are on the anterior side.
The dorsal rami provide nerve function for the skin of the trunk and posterior muscles. The ventral rami from T1 to T12 provide nerve function to the skin of the trunk as well as the lateral and anterior muscles. The anterior divisions that remain for plexuses, networks that provide nerve function to the body. Each plexus has specific areas on the body for skin sensitivity as well as certain muscles. Their point where they exit the spine determines how they are numbered. The four primary plexuses are:
Cervical plexus, C1 � C4, innervates the diaphragm, shoulder, and neck
Brachial plexus, C5 � T1, innervates the upper limbs
Lumbar plexus, T12/L1 � L4, innervates the thigh
Sacral plexus, L4 � S4, innervates the leg and foot.
These spinal nerves have two sets of fibers: motor and sensory. Motor fibers facilitate movement and provide nerve function to the muscles. Sensory fibers facilitate sensitivities to touch, temperature and other stimuli. They provide nerve function to the skin.
Contents
What are Myotomes and Dermatomes?
A group of muscles that are innervated by the motor fibers that stem from a specific nerve root is called a myotome. An area of the skin that is innervated by the sensory fibers that stem from a specific nerve root is called a dermatome. These patterns of myotome and dermatome are almost always identical from person to person. There are occasionally variances, but that is rare.
This consistency allows doctors to treat nerve pain in patients. If a specific area is hurting, they know that it is attributed to a certain myotome or dermatome, whichever the case may be, and its corresponding nerve root. Problems with nerve damage are often the result of stretching the nerve or compressing it.
When the nerves are injured in specific areas like the lumbosacral or brachial plexus, it presents as sensory and motor deficits in the limbs that correspond to them. Myotomes and dermatomes are used to assess the extent of the damage.
How are Myotomes and Dermatomes used to Assess Nerve Damage?
When a doctor tests for nerve root damage in a patient, he or she will often test the myotomes or dermatomes for the nerves assigned to that location. A dermatome is examined for abnormal sensation, such as hypersensitivity or lack of sensitivity.
This is done by using stimulus inducing tools such as a pen, paper clip, pinwheel, fingernails, cotton ball, or pads of the fingers. The patient is instructed to provide feedback regarding their response. Some of the abnormal sensation responses include:
A myotome is tested for nerve damage in the muscles which presents as muscle weakness. This grading scale, which assigns a rating to the degree of muscle weakness, is often used:
5 � Normal � Complete range of motion against gravity with full resistance
4 � Good � Complete range of motion against gravity with some resistance
3 � Fair � Complete range of motion against gravity with no resistance, active ROM
2 � Poor � Complete range of motion with some assistance and gravity eliminated
1 � Trace � Evidence of slight muscular contraction, no joint motion evident
0 � Zero � No evidence of muscle contraction
During a typical chiropractic exam, your chiropractor will assess both dermatomes and myotomes for potential neurological problems. This gives them additional insight on how to treat your condition, whether it’s related to a subluxation of vertebral bodies or other, other disease processes.
Hiking�with the family and you twist your ankle. It hurts, but you make it back without much problem. You notice you have some swelling and soreness, so you head home for some R.I.C.E. (rest, ice, compression, elevation).
You pass it off, saying, �Oh, it�s just a sprain.� But when your doctor checks you out the next day, he tells you that it is �strained.� Sprain vs. strain, what�s the difference?
While many people use the two terms interchangeably, they are not the same. There are some distinct differences although many of the symptoms are almost identical. In short, when a ligament is injured, it is called a sprain. When a muscle or tendon is injured, it is called a strain.
Contents
What Exactly are Sprains & Strains?
Ligaments are tough bands of tissue that connect two bones as they sit in a joint. For example, the tibia and fibula come together to fit in the ankle joint. Tendons join those two bones together to keep the ankle stable. A joint sprain occurs when these ligaments are torn or overstretched. The ankle is the most commonly sprained joint.
Tendons are cords of tissue made up of a dense network of fibers. They connect the muscle to the bone. A joint strain occurs when the tendons or muscles tear or overstretch. The lower back and hamstrings are the most common areas for muscle strain.
Both injuries are very similar, so it stands to reason that the symptoms of the injuries are also almost identical. This is why they are so commonly confused.
Symptoms of Sprains & Strains
The symptoms for each condition is very similar, but there are some differences.
Symptoms of Sprains include:
Pain around the area that is affected
Bruising in the affected area
Swelling in the immediate area but can expand to encompass more area
Limited range of motion
Decreased flexibility
Symptoms of Strains include:
Pain at the site of the joint that is affected
Muscle spasm
Swelling in the immediate area but can expand to encompass more area
Limited range of motion
Decreased flexibility
As you can see, the symptoms of sprains and strains are very close. The primary differences though are that bruising may occur with a sprain while a strain may elicit muscle spasms in the muscle that is affected.
What Causes Sprains and Strains?
Experiencing a sprain or strain every once in a while is not out of the ordinary. We put our bodies through a lot in a day. However, certain activities can make you more susceptible to movements that can lead to these injuries. They include:
Exercise or athletic activities, especially those that are high impact
Walking
Repetitive motion for a long period of time
Overexertion
Jogging or running
Slipping or falling
Standing or sitting in an unnatural or awkward position
Walking or running on unstable surfaces, like rocks or ice
Lifting objects that are too heavy
The most common areas for these injuries include:
Back
Ankle
Wrist
Knee
Thumb
How to Avoid Sprains and Strains
Sometimes injuries just happen and there�s nothing you can do about it. However, in most cases, you can take proactive steps to minimize your risks. These are some of the most common risk factors:
Being in poor physical condition
Using proper form when exercising
Failing to warm up before activities like exercising
Not using the right equipment for your workout or sporting activity.
Maintaining a hazardous environment at home, such as clutter on the floor or things you can trip over or slip on.
Fatigue or overly tired
Failure to avoid hazardous areas like floors that are wet and slippery or sidewalks that are iced over and slick.
If you have a sprain or strain and notice that the swelling has not subsided or if you still have pain after a week or so, you need to follow up with your doctor to make sure you don�t have a more severe injury.
*Sciatica Pain* Treatment Relief | El Paso, TX (2019)
Dr. Alex Jimenez Discusses Microbiome and Methylation
Research studies have demonstrated that our microbiome can help regulate our DNA methylation. The human microbiome is considered to be a counterpart to the human genome. In current research studies, the methylation of intestinal epithelial cells was determined to be considerably abnormal in germ-free mouse models when compared with conventional controls. This research study also demonstrated that bacteria introduced through fecal transplants considerably increased CpG methylation.
Moreover, research studies have determined that gut microbes may also produce butyrate, which can potently prevent the development of histone deacetylase, ultimately affecting the function of DNA methylation. Researchers have discussed that these outcome measures suggest our microbiome may play a fundamental role in host epigenetic regulation, beyond digestive health.
Specific types of bacteria may also cause different effects on DNA methylation. In one human pilot research study, increased levels of the bacterial phylum Firmicutes, compared to the bacterial phylum Bacteroidetes, were associated with the increased methylation of 568 genes as well as the decreased methylation of 245 genes (P=0.05). The affected genes were associated with a variety of health issues, including inflammation, cardiovascular disease, and cancer. Previous research studies in humans have also identified various ratios of the bacterial phylum Firmicutes and the bacterial phylum Bacteroidetes in overweight and obese individuals.
Gut Microbiota and Nutrient Status
Our gut microbiota can also affect our nutrient status and this may also indirectly affect our or DNA methylation. The majority of Lactobacillus species are in vitro consumers of folate with the exception of L. plantarum strains which can produce folate in the presence of para-aminobenzoic acid, or PABA. Many Bifidobacteria species, including strains of B. bifidum and B. infantis, can also produce folate, along with B. breve, B. longum, B. adolescentis, and B. pseudocatenulatum. Many of these species also produce folate in both its THF and 5mTHF forms, with B. adolescentis producing the highest levels of methylated folate.
In vivo, the administration of B. adolescentis, referred to as MB 227 and MB 239, and B. pseudocatenulatum, referred to as MB 116, increased serum folate levels in folate-deficient rats and the co-administration of prebiotic fructans increased serum folate levels further in folate-deficient rats. While human folate absorption generally occurs in the small intestine, it can also occur in the colon. By way of instance, the administration of B. longum in hemodialysis patients decreased serum homocysteine levels the same as serum folate levels increased in folate-deficient through the administration of a variety of bacteria in the gastrointestinal tract.
Furthermore, abnormal populations of bacteria in the small intestine can prevent normal nutrient absorption and appetite signaling, ultimately affecting DNA methylation. An abnormal microbiome may also cause inflammation which, as we have previously discussed, can also affect methylation. A healthy microbiome can ultimately be achieved through proper nutrition and lifestyle habits. Smoothies and juices, such as those described below, can also help improve DNA methylation as well as promote a healthy microbiome.
The human microbiota is made up of 10 to 100 trillion symbiotic microbial cells, most of these which primarily consist of gut bacteria. The role of our microbiome is fundamental towards our overall health and wellness, especially when it comes to DNA methylation activity and status, according to research studies. The human microbiota is important for a variety of bodily functions and recent research studies have demonstrated that an abnormal microbiome can tremendously affect methylation, a chemical process which affects the function of genes as well as gene expression and promotes several essential functions.
Dr. Alex Jimenez D.C., C.C.S.T. Insight
Smoothies and Juices for Methylation Support
While many healthcare professionals can recommend nutritional guidelines and lifestyle modifications to improve methylation support, there are several options you can try yourself at home. As described above, methylation support supplementation should be determined by a healthcare professional. Smoothies and juices are a fast and easy way to include all the necessary nutrients you need for methylation support without any side-effects. The smoothies and juices below are part of the Methylation Diet Food Plan.
Sea Green Smoothie Servings: 1 Cook time: 5-10 minutes � 1/2 cup cantaloupe, cubed � 1/2 banana � 1 handful of kale or spinach � 1 handful of Swiss chard � 1/4 avocado � 2 teaspoons spirulina powder � 1 cup water � 3 or more ice cubes Blend all ingredients in a high-speed blender until completely smooth and enjoy!
Berry Bliss Smoothie Servings: 1 Cook time: 5-10 minutes � 1/2 cup blueberries (fresh or frozen, preferably wild) � 1 medium carrot, roughly chopped � 1 tablespoon ground flaxseed or chia seed � 1 tablespoons almonds � Water (to desired consistency) � Ice cubes (optional, may omit if using frozen blueberries) Blend all ingredients in a high-speed blender until smooth and creamy. Best served immediately!
Sweet and Spicy Juice Servings: 1 Cook time: 5-10 minutes � 1 cup honeydew melons � 3 cups spinach, rinsed � 3 cups Swiss chard, rinsed � 1 bunch cilantro (leaves and stems), rinsed � 1-inch knob of ginger, rinsed, peeled and chopped � 2-3 knobs whole turmeric root (optional), rinsed, peeled and chopped Juice all ingredients in a high-quality juicer. Best served immediately!
Ginger Greens Juice Servings: 1 Cook time: 5-10 minutes � 1 cup pineapple cubes � 1 apple, sliced � 1-inch knob of ginger, rinsed, peeled and chopped � 3 cups kale, rinsed and roughly chopped or ripped � 5 cups Swiss chard, rinsed and roughly chopped or ripped Juice all ingredients in a high-quality juicer. Best served immediately!
Zesty Beet Juice Servings: 1 Cook time: 5-10 minutes � 1 grapefruit, peeled and sliced � 1 apple, washed and sliced � 1 whole beet, and leaves if you have them, washed and sliced � 1-inch knob of ginger, rinsed, peeled and chopped Juice all ingredients in a high-quality juicer. Best served immediately!
Protein Power Smoothie Serving: 1 Cook time: 5 minutes � 1 scoop protein powder � 1 tablespoon ground flaxseed � 1/2 banana � 1 kiwi, peeled � 1/2 teaspoon cinnamon � Pinch of cardamom � Non-dairy milk or water, enough to achieve desired consistency Blend all ingredients in a high-powered blender until completely smooth. Best served immediately!
ProLon� Fasting Mimicking Diet
Balanced methylation support can be achieved through proper nutrition. The ProLon� fasting mimicking diet offers a 5-day meal program which has been individually packed and labeled to serve the foods you need for the FMD in precise quantities and combinations. The meal program is made up of ready-to-eat or easy-to-prepare, plant-based foods, including bars, soups, snacks, supplements, a drink concentrate, and teas. The products are scientifically formulated and great tasting. Before starting the ProLon� fasting mimicking diet, 5-day meal program, please make sure to talk to a healthcare professional to find out if the FMD is right for you. The ProLon� fasting mimicking diet can help promote methylation support, among a variety of other healthy benefits.
Many doctors and functional medicine practitioners may suggest evaluating a patient’s microbiome to determine their DNA methylation status. Through proper nutrition and lifestyle habits, a healthy microbiome can improve methylation. The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .
Curated by Dr. Alex Jimenez
Additional Topic Discussion: Acute Back Pain
Back pain is one of the most prevalent causes of disability and missed days at work worldwide. Back pain attributes to the second most common reason for doctor office visits, outnumbered only by upper-respiratory infections. Approximately 80 percent of the population will experience back pain at least once throughout their life. Your spine is a complex structure made up of bones, joints, ligaments, and muscles, among other soft tissues. Injuries and/or aggravated conditions, such as herniated discs, can eventually lead to symptoms of back pain. Sports injuries or automobile accident injuries are often the most frequent cause of back pain, however, sometimes the simplest of movements can have painful results. Fortunately, alternative treatment options, such as chiropractic care, can help ease back pain through the use of spinal adjustments and manual manipulations, ultimately improving pain relief.
Formulas for Methylation Support
XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly, Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
For your convenience and review of the XYMOGEN products please review the following link.*XYMOGEN-Catalog-Download
* All the above XYMOGEN policies remain strictly in force.
Doctors are always saying exercise, get fit, but don�t give us many realistic options. Going to the gym can be difficult, especially if you are short on time.
Exercising at home can be a real pain, as well. You might be limited for space, tripping over kids � and although no one talks about it, do you want your significant other watching you sweat and gasp for air as you struggle through one of those insane workouts?
They say walking is good, but if you are in a neighborhood that doesn�t have sidewalks or it is too hot outside. Just how likely are you to get up and do it? Now suppose you could get all your exercising done in 7 minutes. Would you do it? Is it even possible?
Nowhere are there heavy weights or fancy equipment, just a wall, a chair, and the person�s body weight. Say hello to high-intensity interval training- it�s about to change your world!
This 7-minute workout is the equivalent of a serious weight training session and long run but without the weights or the running. That isn�t to say it is easy though. It requires a great deal of effort.
There�s a lot packed into those 7 minutes. It provides many of the benefits that are achieved by disciplined, long term endurance training; it just skips over the long-term part.
Make no mistake though, short does not mean it is easy � or pleasant. In fact, it may be one of the longer 7 minutes of your life.
The good news is, it�s over in 7 minutes. That�s a little more than 5 but less than 10.
It�s worth it though when you look at the numerous health benefits that exercise provides. Plus, it�s great for people who are super busy and can�t seem to squeeze a workout into their schedules. Say hello to no more excuses!
The Science Behind the 7
These 12 exercises were not chosen at random. The reason it works is rooted in some pretty deep science. When you exercise for even a few minutes and are operating at or near your maximum capacity (that means you are working very hard), it causes your muscles to experience molecular changes that are much like those that occur after several hours of riding a bike or running.
Interval training takes it a step farther. You engage in incredibly intense activity, then you have a brief recovery period, then back to a high-intensity exercise. That is the basis of this workout.
Each exercise should be done for about 30 seconds with a 10 second recovery period – but there�s a twist that ups the effectiveness even more. The exercises are arranged so that they engage the large muscles in the upper body, then in the lower body.
This alternating focus on muscle groups is essential because while the lower body is working like crazy, the upper body can be catching its breath. This makes for a much more efficient workout, but it is also why the order of the exercises is critical.
The exercises are intense but are movements that just about anyone can do. Many can also be adapted for people at different fitness levels. If you are looking for a great workout that will work for you but won�t eat up a lot of your time, you just might have found it.
Dr. Alex Jimenez Explains Methylation, Nutrition & Lifestyle Habits
A variety of healthcare professionals recommend full MDL or portions of the program to their patients. Research studies report that participants have responded well to the diet plan. By way of instance, a 57-year-old male diagnosed with diffuse myalgia and arthralgia as well as a history of toxic mold exposure, who had a methyl donor intolerance and who had a baseline homocysteine of 15.7. After one month of the MDL program, his follow-up homocysteine was 11.8, which reduced his symptoms. No additional modifications were made to his diet plan. Functional medicine practitioners and doctors may utilize the MDL program in a variety of ways, including:
As a treatment for long-term methylation support
Together with folate and other supplements to improve effectiveness
As an alternative treatment option for people with methyl donor intolerance
In this article, however, we will discuss the importance of obtaining nutrients from food rather than with supplementation. The following information reviews the foundational interventions which are relevant to the Methylation Diet and Lifestyle, or MDL, program. We will also provide a collection of smoothies and juices which can help promote methylation support and effectiveness. According to healthcare professionals, nutrients from foods improve methylation support and address significant genetic SNPs.
Food-Based Nutrients
Improving methylation through non-fortified whole foods is a safe and effective treatment, as long as enough of the relevant nutrients are consumed. During a 16-week human placebo-controlled trial, an increase of 200 mcg/d folate from folate-rich foods demonstrated the same capability to increase plasma and erythrocyte folate levels as well as to lower homocysteine compared with an equal amount of supplemental folic acid or 5-mTHF as Metafolin�. Dietary folate, along with changes to lifestyle habits, can improve methylation.
There is currently no limit set for folate intake from non-fortified foods and no research studies have found side-effects from folates and other methylation nutrients from foods. But, what amount of nutrient intake is enough to optimize methylation status? This will inevitably be different for each individual based on their genetic fingerprint and environmental factors. A Cochrane systematic review, published in 2014, demonstrated that food-sourced folate could protect against the risk of cancer, specifically breast cancer, within the range of 153 � 400 mcg/d, suggesting that increased supplementation is not necessarily beneficial for the general population.
However, specific populations may have genetic or environmental factors which may need them to have higher nutrient intakes. There are a variety of nutrients involved with methylation enzymes and pathways, demonstrated as either substrates or cofactors. Table 6 below, lists these important nutrients and their dietary sources, including methionine, cysteine, taurine, DHA, zinc, magnesium, potassium, riboflavin, niacin, pyridoxine, folate, vitamin B12, betaine, choline, and sulfur. Several of these nutrients have previously been utilized as targeted supplements by many functional medicine practitioners or doctors for a wide variety of diet plans.
Depending on the genotype of the individual, nutrient intake needs can be further customized to support an individual’s potential enzyme deficiencies. Individuals with specific SNPs may benefit from increased intake of cofactor nutrients used by the associated enzyme because it has been demonstrated that increased cofactor intake can push the rate of enzymatic reactions forward. Table 7 below, lists commonly examined methylation-related genes and the nutrients that can be used to support activity and status, including MTHFR, MTR, MTRR, MAT1A, MAO, COMT, CBS, MTRR, and BHMT, as well as their cofactor nutrient support.
Nutrient Assimilation
If an individual’s needs are determined either by laboratory testing or physical exam findings, the Five-R Protocol utilized as a part of the MDL program, is outlined in Table 8 as an ideal way to improve nutrient assimilation and functional status. It can be done together with a short-term course of methylation supplementation with subsequent transition to the MDL or with the MDL from the start. Functional medicine practitioners or doctors may recommend changes to nutrition and lifestyle habits for methylation support.
Nutrient supplementation is commonly used to help promote methylation support, however, research studies have demonstrated that the best way to improve methylation activity and its overall status is through food-based nutrient intake. High doses of supplements have been known to cause side-effects but eating nutrient-rich foods provides the same if not greater benefits than supplementation. Smoothies and juices such as those listed below can promote methylation support.
Dr. Alex Jimenez D.C., C.C.S.T. Insight
Smoothies and Juices for Methylation Support
While many healthcare professionals can recommend nutritional guidelines and lifestyle modifications to improve methylation support, there are several options you can try yourself at home. As described above, methylation support supplementation should be determined by a healthcare professional. Smoothies and juices are a fast and easy way to include all the necessary nutrients you need for methylation support without any side-effects. The smoothies and juices below are part of the Methylation Diet Food Plan.
Sea Green Smoothie Servings: 1 Cook time: 5-10 minutes � 1/2 cup cantaloupe, cubed � 1/2 banana � 1 handful of kale or spinach � 1 handful of Swiss chard � 1/4 avocado � 2 teaspoons spirulina powder � 1 cup water � 3 or more ice cubes Blend all ingredients in a high-speed blender until completely smooth and enjoy!
Berry Bliss Smoothie Servings: 1 Cook time: 5-10 minutes � 1/2 cup blueberries (fresh or frozen, preferably wild) � 1 medium carrot, roughly chopped � 1 tablespoon ground flaxseed or chia seed � 1 tablespoons almonds � Water (to desired consistency) � Ice cubes (optional, may omit if using frozen blueberries) Blend all ingredients in a high-speed blender until smooth and creamy. Best served immediately!
Sweet and Spicy Juice Servings: 1 Cook time: 5-10 minutes � 1 cup honeydew melons � 3 cups spinach, rinsed � 3 cups Swiss chard, rinsed � 1 bunch cilantro (leaves and stems), rinsed � 1-inch knob of ginger, rinsed, peeled and chopped � 2-3 knobs whole turmeric root (optional), rinsed, peeled and chopped Juice all ingredients in a high-quality juicer. Best served immediately!
Ginger Greens Juice Servings: 1 Cook time: 5-10 minutes � 1 cup pineapple cubes � 1 apple, sliced � 1-inch knob of ginger, rinsed, peeled and chopped � 3 cups kale, rinsed and roughly chopped or ripped � 5 cups Swiss chard, rinsed and roughly chopped or ripped Juice all ingredients in a high-quality juicer. Best served immediately!
Zesty Beet Juice Servings: 1 Cook time: 5-10 minutes � 1 grapefruit, peeled and sliced � 1 apple, washed and sliced � 1 whole beet, and leaves if you have them, washed and sliced � 1-inch knob of ginger, rinsed, peeled and chopped Juice all ingredients in a high-quality juicer. Best served immediately!
Protein Power Smoothie Serving: 1 Cook time: 5 minutes � 1 scoop protein powder � 1 tablespoon ground flaxseed � 1/2 banana � 1 kiwi, peeled � 1/2 teaspoon cinnamon � Pinch of cardamom � Non-dairy milk or water, enough to achieve desired consistency Blend all ingredients in a high-powered blender until completely smooth. Best served immediately!
ProLon� Fasting Mimicking Diet
Balanced methylation support can be achieved through proper nutrition. The ProLon� fasting mimicking diet offers a 5-day meal program which has been individually packed and labeled to serve the foods you need for the FMD in precise quantities and combinations. The meal program is made up of ready-to-eat or easy-to-prepare, plant-based foods, including bars, soups, snacks, supplements, a drink concentrate, and teas. The products are scientifically formulated and great tasting. Before starting the ProLon� fasting mimicking diet, 5-day meal program, please make sure to talk to a healthcare professional to find out if the FMD is right for you. The ProLon� fasting mimicking diet can help promote methylation support, among a variety of other healthy benefits.
Many doctors and functional medicine practitioners may recommend higher doses of methyl donors in several patients, however, further research studies are needed to determine the proper amount of methylation supplementation. The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .
Curated by Dr. Alex Jimenez
Additional Topic Discussion: Acute Back Pain
Back pain is one of the most prevalent causes of disability and missed days at work worldwide. Back pain attributes to the second most common reason for doctor office visits, outnumbered only by upper-respiratory infections. Approximately 80 percent of the population will experience back pain at least once throughout their life. Your spine is a complex structure made up of bones, joints, ligaments, and muscles, among other soft tissues. Injuries and/or aggravated conditions, such as herniated discs, can eventually lead to symptoms of back pain. Sports injuries or automobile accident injuries are often the most frequent cause of back pain, however, sometimes the simplest of movements can have painful results. Fortunately, alternative treatment options, such as chiropractic care, can help ease back pain through the use of spinal adjustments and manual manipulations, ultimately improving pain relief.
Formulas for Methylation Support
XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly, Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
For your convenience and review of the XYMOGEN products please review the following link.*XYMOGEN-Catalog-Download
* All the above XYMOGEN policies remain strictly in force.
Most people now acknowledge just how bad sugar is. The problem is, many are not willing to give it up. The evidence is clear though, over the last three decades chronic disease like diabetes, cancer, and heart disease have grown exponentially in occurrences that correlate strongly with Americans� ever-increasing intake of sugar.
But while this may not be new information, people are still unwilling to make the changes necessary � even with the threat of poor or worsening health (and even death) hanging over their heads.
One of the problems is that it is very difficult to get away from. Pick up almost any product on your grocery store shelves and read the ingredients. Sugar is there most of the time.
It is found in most processed foods including spaghetti sauce, salad dressings, dried fruit, fruit juices, even so-called �healthy� foods like frozen quinoa blends and �diet� frozen dinners. Sugar is everywhere and people are consuming it without even realizing that they are doing so.
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Sugar is Addictive
Again, this is not new information, but many people don�t realize just how addictive sugar really is. One research article compared sugar addiction to drug addiction. The authors even went so far as to say sugar is as addictive as cocaine (or more so).
There is strong evidence to support this; sugar does affect a person at the neurobiological level. It activates the brain�s reward center, similar to what drugs do. Regular exposure provokes cravings similar to drug addiction and withdrawal symptoms when it is stopped.
The real problem here is that it is 1) legal, and 2) available for anyone to purchase- even children. There is a huge push to market sugar to children through heavily sugared cereals, drinks, and snack foods.
The children want it because they saw it on TV, the parents buy it, and the children end up cognitively impaired, obese, and chronically ill. It�s time to start connecting the dots and making significant changes in not only what we eat, but what we feed our children.
But Why is Sugar so Bad?
In its pure form, right out of the sugar cane, the juice has nutritional properties. However, all of that nutrition is destroyed when it is processed and refined as sugar (even “raw,” turbinado, and other forms – it’s still sugar). It becomes something that may be edible but isn�t really food. It is just a substance with absolutely no nutritional value � but lots of potential for damage.
The moment sugar enters your bloodstream your body begins secreting insulin. Insulin is produced in the pancreas and its function is to regulate sugar in the blood, to keep it balanced. When you overwhelm your body with sugar it keeps producing more and more insulin. A diet that is high in sugar can result in insulin resistance which can lead to obesity, diabetes, high blood pressure, and other dangerous conditions.
The more sugar you consume, the harder your body has to work to process it. It gets stored in the liver, leading to a fatty, enlarged liver, high glucose levels, and even affect the function of your organs including your kidneys. If you have conditions like heart disease, diabetes, or high blood pressure, the risk of damage to your organs is increased even more.
High glucose levels have also been linked to impaired cognitive function, loss of memory, depression, and anxiety as well as an increased risk of dementia. It can cause difficulty in concentration and the inability to focus or stay on task.
The solution here is to avoid sugar or make low sugar choices. Read labels! Take the time to think about what you are putting into your body and how it will affect you. If you make a conscious effort to reduce your sugar intake, over time your body will stop craving it.
*Detox Your Body* | Detox Doctor | El Paso, TX (2019)
The ketogenic diet, also known as a low carb diet is being talked about in various circles. And while science has proven over and over about the numerous health benefits, there are still those that want to disclaim it. This guide will explain the ketogenic diet, ketones, and the many health benefits that this way of eating provides.
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What are Exogenous Ketones?
In order to understand exogenous ketones, it is important to first know what ketones are. Simply put, ketones are carbon-based, organic compounds that are produced in the liver. They are used by the mitochondria within the body to generate energy and can replace glucose as a fuel source, putting the body in a state of ketosis.
Exogenous ketones are ketones that are taken into the body as nutritional supplements. Endogenous ketones are produced in the body, specifically, the liver. Exogenous ketones are not produced in the body, rather are introduced into the body through supplements.
What is a Ketogenic Diet?
A ketogenic diet is characterized by three primary markers:
Low carbohydrate
Adequate protein
High fat
It is designed to put the body into a state of ketosis which means that instead of burning carbohydrates for energy, it is forced to burn fat.
When the body consumes foods that are high in carbs, it begins to produce insulin and glucose. Glucose happens to be the path of least resistance when it comes to energy conversion and usage, so the body will opt for that route before any utilizing another energy source.
What are the Benefits of a Ketogenic Diet?
There are several significant health benefits of a ketogenic diet. It was developed to be a way of life (WOL), not just a temporary diet and this was primarily due to the health benefits it provides. In fact, ketone diets were created to help allay or improve the symptoms of certain chronic health conditions, including epilepsy. Other benefits of the ketogenic diet include:
Weight loss
Lower insulin levels and reduced blood sugar
Lower triglycerides
Effectively treats metabolic syndrome
Forces the body to burn fat
Increased HDL (�good� cholesterol) levels
Improve LDL
Prevention of certain cancers
Potential to kill certain cancer cells
Lowered blood pressure
Improve epilepsy symptoms
Help treat Parkinson�s Disease
Reverse and treat symptoms of Alzheimer�s
The weight loss occurs from a ketogenic diet is largely fat loss – particularly abdominal fat (visceral fat). It is visceral fat that increases the risk of heart disease, type 2 diabetes, and other health conditions.
A ketogenic diet helps to reduce many of the risks of some of the most debilitating and even deadly chronic health conditions that are so prevalent today. Exogenous ketones provide a powerful supplementation to the diet, improving its effectiveness.
A ketogenic diet is not a quick fix or fad diet; it is indeed a way of life. While many people do see very noticeable results quite quickly, the substantial health benefits that it provides make it worthy of a lifelong commitment. By adhering to this low carb lifestyle, you can reverse many health conditions and avoid others. In short, you will enjoy increased energy and better health for years to come.
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