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Is an Enzyme Making You Fat?

Is an Enzyme Making You Fat?

Researchers say they’ve found an enzyme in mice associated with obesity and a loss of exercise capacity in midlife, suggesting that the discovery could eventually lead to new weight-loss medications.

The team at the U.S. National Heart, Lung, and Blood Institute (NHLBI) gave one group of mice a drug that inhibits the activity of the enzyme called DNA-PK. Another group of mice wasn’t given the drug. Both groups were fed a high-fat diet.

The group that received the inhibitor had 40 percent less weight gain than the other group, according to the study in the journal Cell Metabolism.

The findings challenge current ideas about why people gain weight as they age, the researchers said.

“Our society attributes the weight gain and lack of exercise at midlife [approximately 30-60 years] primarily to poor lifestyle choices and lack of willpower,” said study lead author Dr. Jay Chung, head of the institute’s Laboratory of Obesity and Aging Research.

The researchers said the average weight gain between age 20 and 50 is about 30 pounds, even though the amount of food a person consumes generally decreases during this time.

Chung and his colleagues looked for biochemical changes in animals during midlife and found that DNA-PK increases in activity with age. Also, the researchers said the enzyme helps the conversion of nutrients to fat.

“This study shows that there is a genetic program driven by an overactive enzyme that promotes weight gain and loss of exercise capacity at midlife,” Chung said in a NHLBI news release.

“Our studies indicate that DNA-PK is one of the drivers of the metabolic and fitness decline that occurs during aging, which makes staying lean and physically fit difficult and increases susceptibility to metabolic diseases like diabetes. The identification of this new mechanism is very important for improving public health,” he said.

Obesity is linked with a number of chronic diseases, including type 2 diabetes and heart disease.

“The study opens the door to the development of a new type of weight-loss medication that could work by inhibiting DNA-PK activity,” Chung said.

However, it’s important to note that research that seems promising in animals doesn’t always translate well to humans.

For now, middle-aged people fighting obesity need to focus on calorie reduction and increased exercise, the researchers recommended.

Could Diet Aggravate Asthma?

Could Diet Aggravate Asthma?

The idea that diet could have a role to play in preventing the signs of asthma is starting to gain ground, with studies highlighting certain deficiencies in patients or warning against the consumption of certain foods. On World Asthma Day, May 2, Relaxnews spoke to Dr. Bertrand Delaisi, a pediatric pulmonologist at Clinique Marcel Sembat in Boulogne-Billancourt, France, for an overview of what’s currently known on the subject.

The prevalence of asthma has increased considerably in recent decades, in parallel with changes in lifestyles and dietary habits, tending towards diets rich in carbohydrates and fat, and low in fiber.

As well as pollutants, allergens, passive smoking and air pollution, allergy specialists are increasingly interested in how diet can promote or modify the development of asthma on a physiopathological level.

Eating ham, cured sausage or smoked meats at least four times a week could aggravate the symptoms of asthma over time, concludes a study carried out by researchers at Inserm, the French National Institute of Health and Medical Research, published in January in the medical journal Thorax.

On the contrary, consuming fiber may influence the gut flora and could reduce inflammation in the bronchial tubes. A diet rich in fruit and vegetables and vitamin C — and especially vitamin D (calf’s liver, soy, egg yolks) — could, therefore, help limit the risks of asthma, according to Dr. Bertrand Delaisi, a pediatric pulmonologist at Clinique Marcel Sembat in Boulogne-Billancourt, France.

The same goes for omega-3 fatty acids, present in oily fish and other foods (walnuts, canola oil), which can relieve inflammation, including in the respiratory airways. People whose diets are rich in omega-3 have a lower risk of suffering from asthma than those whose intake is limited. They could also be beneficial to people who already suffer from the condition.

Foods containing quercetin could reduce the frequency of asthma attacks, as this antioxidant flavonoid is an anti-inflammatory. Studies carried out in vitro found that quercetin inhibited the liberation of inflammatory substances by mast cells, which play a role in allergic reactions, mirroring certain anti-asthma medications. This antioxidant is found in onions, mustard oil, tea and apples.

An estimated 300 million people worldwide suffer from asthma.

High Heels Can Cause Back, Knee & Hip Pain

High Heels Can Cause Back, Knee & Hip Pain

Doctor of Chiropractic, Dr. Alexander Jimenez looks at high heels at what they do to the back.

Ladies, ever wonder why you suffer from regular bouts of lower back pain?� Achy hips?� How about crazy tight leg muscles?� Don�t blame it on your cycling class, or too many squats or, the trainer you only see once or twice a week.� Look down.� Are you wearing high heels?� Bingo!� You�ve heard high heels are bad for you.� But it�s not just because they cause all kinds of pain and trauma to your feet.� High heels are also messing up your physical fitness. �They throw you out of proper postural alignment causing your joints and spine to take on more�wear and tear, which means aches and pains.

Is it possible to still look rockin� and save your joints? �My suggestion is more Athleisure-wear. �I know some fashion hard-liners say, no way will I walk around in yoga pants on a weekday!� But we�ve come a long way since those flare-leg, fold-over yoga pants.

Let�s chat for a moment about the evils of high heels.

First there�s the obvious.� They make your feet hurt.� Blisters, calluses and swelling are par for the course.� And pointy toes, fuhgeddaboutit!� I�m sure they were invented by someone on the Marquis de Sade�s payroll.� Second, they can lead to foot injuries like plantar fasciitis (usually from a bone spur that makes your heels hurt), hammertoes, bunions, and neuromas.� �Then there�s the domino effect.

Not only do high heels make your feet hurt, but problems with the feet can travel up the leg and cause injuries in the back, knees and hips. �Your knees take on extra pressure from the weight being pushed forward onto the balls of the feet. �Walking in this position makes your hip flexors and calf muscles short and tight. �And it doesn�t stop there.� Back problems are incredibly common in women who don�t give up their high heels.

 

 

Back Problems are incredibly common in women who don�t give up their high heels

Here�s why:

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  1. Postural changes:�The S-curve of your spine has cushiony discs in between the vertebrae that act as a shock absorbers to protect them from stress. Like when you�re bending or jumping. �Wearing heels causes the lower back to arch more than normal because the body weight is pushed forward.� To compensate, the upper body has to lean back to maintain balance.� This puts extra stress on the discs. ��Spending hours with your body in funky alignment can lead to muscle spasms and back pain. �Tight hamstring muscles, which�attach to back of the pelvis and lower back, can also make your back ache.
  2. Anatomical changes: Wearing high heels on a daily, or very regular basis, over years, can actually cause anatomical changes to your body.� In addition to the extra strain on your back and knees, the calf muscles can also shorten and the tendons can get tighter and thicker.

And It Can Get Even Nastier If You Get One Of These Spine Injuries:

 

  • Spondylolisthesis: it�s a mouthful, but is a common injury that can happen in the lower back from too much hyperextension (arching the back).� It�s when one vertebra slips forward over another.
  • Foraminal stenosis: I have this one congenitally and it sucks. This is a spine and nerve issue that occurs when anatomical abnormalities reduce the spaces the nerves travel through as they exit the spinal column.� The spaces are called foramina, and when they get blocked, the nerves get squeezed.� The pain can radiate through the buttocks and down the legs.� Symptoms are shooting pains, numbness, tingling, muscle weakness, spasms and, or cramping.
  • Sciatica: The sciatic nerve is the longest one in the body. �It runs from the bottom of the lumbar spine all the ways down the legs. �When the sciatic nerve gets compressed it causes radiating pain, tingling, numbness and muscle weakness down the leg and can The pain can travel all the way to the bottom of the foot.

What Can You Do? �My Case for Athleisure-Wear To Combat Back Pain

 

 

It�s time for stuffy office attire to retire. �Comfy clothes and flat shoes can be very chic. �Have you seen the boards on Pinterest?� Thanks to this hopefully permanent fashion style, my jeans and heels spend more time in my closet than on my body.� Leggings and cute kicks are my go to�s.� Night out?� No prob.� I reach for my sleek workout leggings, a ruched top or off the shoulder top with some high heel sneaks (they�re wedges so not nearly as bad for you). �I also discovered these by Bluprint which I put to the test at 2 huge conventions where I walking and standing for hours on end.� The soles made of memory foam � like those beds!

 

 

My podiatrist friend, Steven Rosenberg, DPM has been preaching the need for comfy shoes to his female clients for years. �(Fortunately for his practice, not everyone listens!) �Dr. Steve says, wearing shoes designed more for comfort can help you live more pain-free. ��Because comfort shoes are made of�soft cushiony materials�with soft foam innersoles, those are what you should turn to for shopping, walking or standing for long periods of time to avoid�blisters, muscle spasms or arch cramps.� � He also says to check for arch support in your shoes. �If there�s none, you can buy ones to put inside.

 

 

 

Even after reading this, you may still not be willing to give up high heels for good. �Me either.� I still get glammed up once in a while.

Here Are Some Tips For When You Must:

  • Wear them for as little time as possible.
  • Try to opt for heels around 2� high
  • Steer clear of pointy toes.
  • Buy shoes with leather insoles to so your foot doesn�t slide.
  • Buy arch inserts or use orthotics to support your arches.
  • Vary your footwear so you�re not wearing high heels every day.
  • Gradual or lower slopes are a little better, go for platforms or wedges instead of stilettos
  • Thicker heels are better than spiky heels
  • Stretch and strengthen the overworked muscles.

 

Here�s How:

  • Stretch your leg muscles and hip flexors before and after wearing heels.� For the calves, stand on a step and let one heel hang down until you feel a stretch.

 

Try this convenient device, the foot rocker by Vive.� It stretches the calf and the sole of the foot relieving pain from plantar fasciitis.

 

 

 

Front of the hip and thigh stretch for before and after wearing high heels

 

Hamstring stretch for before and after wearing high heels

 

  • Massage and stretch the muscles in the soles of your feet.� Roll your foot on a golf ball before and after wearing heels and, get regular foot massages.
  • Strengthen and increase the range of motion in your ankles and feet.� Put a rag on the floor.� Using your foot, write the letters of the alphabet.� Also put a bunch of marbles on the floor.� Pick one or a few of them up using just your foot.� Put them down about 6 inches away without lifting your foot off the floor.� Try that 10 times.� If you don�t have marbles, you can do it with a hand towel.

 

 

So next time you�re shopping for shoes, think about your foot fitness first. �Look for fashion that keeps you closer to the ground and that will hopefully keep you farther away from the doctor.

 

Call Today!

Yes, It’s Possible To Exercise Too Much: Here Are The Signs

Yes, It’s Possible To Exercise Too Much: Here Are The Signs

Make the most of your rest days

Help your body recover with these self-care strategies from pros.

Eat well and hydrate: “You should be feeding your body nutrient-dense foods, like lean proteins and veggies,” says Rosante. “And be sure to drink plenty of water.”

Use a foam roller: “Imagine knots on a rubber band�trigger points are like that, and exercising can inflame them,” notes Rosante. “Rolling out breaks them up so you cna move better.”

Walk around: “Long walks help increase blood flow to the muscles,” explains Rosante, “bringing oxygen to fix damaged tissue.”

Don’t binge on junk food: “A rest day is not a cheat day,” notes Holder.

Don’t stay up all night: “Sleep is key for your body to recover, repair�muscles, and reset the brain,” says Holder. “Not getting enough can increase food cravings and push your body into chronic stress mode, making it harder to meet your goals.”

Don’t train�duh!: Sounds simple, but it can be challenging. Proper rest optimizes the body for future workouts. And don’t worry: “No gains will be lost in one or even two days,” adds Jon-Erik Kawamoto, founder of JK Conditioning in Newfoundland, Canada. To put it another way: Namaste…in bed.

This Invigorating Yoga Flow Is the Best Way to Get Energized

This Invigorating Yoga Flow Is the Best Way to Get Energized

When the going gets tough, yoga. That’s our mantra this spring—and this flow is proof that deep breaths and a little movement can work wonders on your energy levels. It’s led by Tiffany Cruikshank, founder of Yoga Medicine and an expert in the restorative power of yoga. The sequence is meant to wake you up, and help you find your center; so you finish your practice calmer than before, but also invigorated. The routine will also help you feel more connected to your body, as you challenge your muscles and build stamina. 

While yoga doesn’t raise your heart rate quite like high-intensity interval training, or HIIT, it does come with its own set of stellar health benefits. Regular yoga sessions can help to reduce migraines, improve sleep quality, and even boost your sex life, thanks to poses that strengthen the pelvic floor muscles (and in turn make your orgasms bigger and better). 

RELATED: 3 Yoga Poses to Relieve Stress and Anxiety

Of course yoga has the power to change your body for the better too. The ancient practice can lead to longer, leaner muscles, since it stretches your limbs while building strength simultaneously. 

Want to get it on the action? Watch the video to follow along as Cruikshank guides you through a yoga flow that will recharge your batteries stat. It’s perfect for vinyasa novices as well as longtime yogis. Whether you do this routine first thing in the morning, or right in the middle of your afternoon slump, it will leave you feeling healthier and happier, guaranteed. And if you just can’t get enough of Tiffany, visit YogaGlo for more of her classes.

6 Easy Ways to Add Cardio to Your Strength Workout

6 Easy Ways to Add Cardio to Your Strength Workout

This article originally appeared on DailyBurn.com.

Resistance training and cardio exercise can indeed co-exist. In fact, blending them together creates the ideal time-saving gym session. All you have to do is make a few intensity-amplifying tweaks to your existing strength workout and it can drive up your heart rate, burn more calories and improve your cardiovascular health, says New York City-based trainer Laura Miranda, DPT, CSCS, exercise physiologist. Get started on getting more from your workout by following these six strategies that marry weights and cardio. You just might find you’re having more fun, too.

RELATED: 6 Killer Cardio Workouts That Don’t Involve Running

6 Tips for Turning Up the Cardio on Your Strength Workout

1. Vary your rest.

The first way to spike your heart rate while strength training: Perform each move back to back with as little rest as possible — that is, while still maintaining good form. Miranda prefers a ladder approach to accomplish this goal. After the first round of resistance exercises, rest for 20 seconds. On the second set, rest for 15 seconds; and the third, pause for a 10-second break. As your body gets less and less time to recover, it taxes your aerobic system, she explains. Keep in mind, because you can’t lift at max weight with this many sets, it’s a good goal for fat loss, rather than strictly strength gains.

RELATED: 12 Brilliant Meal Prep Ideas to Save Time 

2. Hold weights in both hands.

Rather than putting all your effort into single-arm movements for exercises like curls, rows or extensions, pick up two dumbbells or kettlebells. Then, go to town. Doing upper-body bilateral movements — like bicep curls with both hands moving at the same time — increases your heart rate more than when focusing on one arm at a time, according to a 2017 study in The Journal of Strength & Conditioning Research.

RELATED: 5 Sports-Inspired Drills That Totally Count as Cardio

3. Pepper in plyometrics.

Explosive movements — think squat jumps and jumping lunges — are super effective and efficient for cranking up your cardio, while still building muscle. To maximize the payoff of these powerful moves, perform at least 15 reps of each exercise. This can keep your heart rate elevated for up to 50 minutes post-exercise, according to one study.

Miranda also recommends combining plyos with a strength and coordination move to lessen some of the jarring impact on your body. For example: Do a dumbbell lateral lunge, followed by a bear crawl, then end with broad jumps. Take a brief rest before cycling through those three exercises again.

RELATED: 3 Plyometric Moves That Turn Up the Burn

4. Lighten your load.

In a traditional strength workout, you’d pick up a weight heavy enough that you could only do a few reps for up to 45 seconds, says Miranda. But to hit the sweet spot where lifting turns more aerobic, opt for lighter weights that allow you to perform a set for one to two minutes. You might even drop the weight altogether and work for longer periods (i.e. go from a weighted squat to simply bodyweight squats). Or, grab a set of five- to eight-pound weights and perform a move like dumbbell uppercuts for one minute. Trust us, it will burn.

RELATED: 3 Quick HIIT Workouts for Beginners 

5. Try a two-fer.

Why do a squat or a bicep curl or an overhead press when you can be super efficient and do all three at once? Compound movements like this one require you to use more muscle groups, which gives you a greater metabolic boost, says Miranda. Even better, these multi-move exercises test your coordination. Some others to add to your exercise repertoire: a push-up with row, reverse lunge with triceps extensions, curtsy lunge with bicep curl or a glute bridge with chest press.

RELATED: 3 Exercises to Sculpt Your Entire Body

6. Go beyond everyday exercises.

No doubt you’ve done a burpee or 10. After all, they’re used in many workouts because they’re an efficient way to get your heart rate up between strength sets. “When you choose movements that your body is not used to doing — like getting on and off the floor, as you do for a burpee — it enhances the difficulty of your workout,” says Miranda. (Typically, we’re used to simply sitting, standing and walking.) A burpee requires you to use all major muscle groups at once, which is probably why research shows this move is nearly as good as bicycle sprints in terms of gaining cardiovascular benefits.

Another similar way to enhance the cardio challenge: Do moves that work your body in different planes of motion, says Miranda. For instance, a forward lunge, followed by a side lunge, then wrap it up with a backward lunge. “Our bodies are not used to moving in those sequences,” she says. Wood chops or 180 squat jumps will also do the trick. So not only will you feel your muscles getting fatigue, but you’ll breath heavy while you’re at it. A single workout for strength and cardio…you’re welcome.

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