The human brain comprises approximately billions of small cells that utilize electrical impulses and chemical signals to communicate with one another and other parts of the human body. These are known as neurons. When neurons stop functioning properly, it can cause various brain disorders, such as Alzheimer’s disease, epilepsy, and even depression.
Researchers developed several treatment methods and techniques of brain stimulation which allow them to control neural activity to understand better and regulate these type of health issues. In conventional treatment methods and techniques of deep brain stimulation, electrical neurostimulators, also known as brain pacemakers, are surgically implanted in the brain.
Researchers also developed non-invasive treatment approaches to stimulate cells found deep within the brain. While several researchers utilize magnetic pulses or sound waves to stimulate neurons, researchers in optogenetics utilize light therapy. Shuo Chen, Ph.D., winner of Science and PINS Prize for Neuromodulation, was recognized for his work in this area.
Dr. Chen demonstrated that near-infrared light, when utilized with certain nanoparticles, allowed the stimulation of neurons deep within the brain, stated Dr. Karl Deisseroth, professor of bioengineering, psychiatry, and behavioral sciences at Stanford University. More research studies are needed to make this a useful process, he said, but Dr. Chen took a key step.
Developing Light-Sensitive Neurons
Dr. Karl Deisseroth, one of the leading pioneers of optogenetics, developed a treatment method or technique in which the brain cells or neurons are genetically engineered to respond to light therapy. Through this method or technique of brain stimulation, researchers transmit fragments of genetic codes from algae and other microbes into the brain cells of mice and other animals. That genetic code ultimately causes neurons to produce light-responsive proteins known as opsins.
When opsin-producing neurons are exposed to specific wavelengths of visible-spectrum light, those brain cells turn on or off. By activating or suppressing the neurons, researchers can learn more about the fundamental role of neurons in brain function and brain disorders. Dr. Karl Deisseroth has also demonstrated the effects of developing light-sensitive neurons.
By developing light-sensitive brain cells, the causal role of cellular activity can be determined in the tissue and the behavior of interest of any species, ranging from memory to mood, stated Dr. Deisseroth. Furthermore, optogenetics brings the unmatched capability for speaking the brain’s natural language regarding cell-type specificity and speed, he added.
Developing Non-Invasive Treatment Approaches
Opsin-producing neurons, however, respond to visible-spectrum light which cant penetrate brain tissue. Therefore, optogenetic stimulation required the insertion of fiber-optic light sources inside the brain to stimulate neurons. Dr. Deisseroth and his colleague Polina Anikeeva, Ph.D., developed the utilization of near-infrared (NIR) light, a non-invasive type of light therapy.
NIR light can ultimately penetrate through the skull and brain tissue without inserting internal light sources inside the brain. However, NIR light also doesn’t trigger a response from opsin-producing neurons. To promote the tissue-penetrating abilities of NIR light therapy, Dr. Karl Deisseroth and Dr. Anikeeva developed a treatment approach known as NIR upconversion, which coats opsin-producing neurons in nanoparticles to convert NIR light into visible-spectrum light.
Dr. Shuo Chen utilized this treatment method and technique, demonstrating for the first time that NIR upconversion optogenetics can ultimately be utilized to control neurons deep in the brains of mice. In addition, Dr. Chen’s research studies utilized this method and technique to stimulate the release of dopamine in a region of the brain believed to play a role in depression.
Overcoming the challenge of optical penetration depth will be the fundamental key to realizing non-invasive remote optogenetics with high clinical translation potential, wrote Dr. Chen in his prizewinning essay on the topic. Our research study utilized a nanomaterial-assisted approach that shifts the existing optogenetic tools into the near-infrared region.
Brain Stimulation for the Human Brain
While researchers continue to research optogenetics in mice and other animals, it hasn’t been utilized to treat brain disorders in humans. Furthermore, more research studies are required to develop and evaluate non-invasive methods of light therapy and non-invasive methods and techniques for transmitting genetic code into brain cells or neurons.
It is too soon to predict which treatment approach will emerge at the forefront of next-generation non-invasive brain stimulation technology, Dr. Chen said in a press release issued by the American Association for the Advancement of Science. However, we believe that a variety of fundamental achievements, such as NIR upconversion optogenetics, are quickly unlocking development pathways and paving the way towards a bright therapeutic future for brain diseases, he continued.
In the meantime, other methods and techniques of non-invasive brain stimulation are also being developed, evaluated, and utilized in humans. For example, transcranial magnetic stimulation (TMS) is a non-invasive treatment approach that utilized magnetic fields to stimulate nerve cells in the brain. The Food & Drug Administration (FDA) has already allowed TMS marketing as a treatment approach for major depression as well as obsessive-compulsive disorder and migraine headaches.
There are also several non-invasive methods and techniques which don’t require the utilization of gene therapies, such as transcranial magnetic and electrical stimulation, which are commonly utilized with human subjects on an experimental, regular basis, stated Ed Boyden, Ph.D., a professor of neurotechnology at the Massachusetts Institute of Technology (MIT).
Members of Boyden”s research study group have also conducted research studies on transcranial electric stimulation (TES), a non-invasive treatment approach to brain stimulation in which electrodes are placed on the scalp. Researchers hope for this method and technique to reach neurons or cells deep within brain tissue with greater precision than TMS.
Although research studies have demonstrated that light therapy can stimulate brain cells or neurons of mice and other animals, urther research studies are required to determine how light therapy treatment methods and techniques can stimulate the human brain. According to these same research studies, light therapy can alter neurons or brain cells which can ultimately cause Alzheimers disease, epilepsy, and other brain diseases. – Dr. Alex Jimenez D.C., C.C.S.T. Insight
The human brain consists of billions of small cells or neurons which communicate with one another and other parts of the human body. When neurons stop functioning properly, it can cause a variety of brain disorders. Researchers have developed a variety of light therapy treatment approaches to help stimulate the brain ultimately. The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues and functional medicine articles, topics, and discussions. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900
Curated by Dr. Alex Jimenez
Additional Topic Discussion: Chronic Pain
Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals; however, chronic pain is different from the average pain type. The human body will continue sending pain signals to the brain with chronic pain, regardless of the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient’s mobility, reducing flexibility, strength, and endurance.
Neural Zoomer Plus for Neurological Disease
Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual’s reactivity to 48 neurological antigens with connections to various neurologically related diseases. The Vibrant Neural ZoomerTM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention.
Mostly everyone in the world has a gluten allergy or gluten sensitivity when they consume food. When it comes to food that has the gluten compound, most people read the labels on the products that contain it and have cut the compound out of their diets completely. However, did you know that different foods and products have hidden gluten in them? Even though now and days we read labels from products, as well as, cutting off the source of the problem that is making us ill. Hidden additives like gluten, even in small amounts, can cause problems to those that are allergic or sensitive to the compound. Especially when it comes to the product itself, some regulations may or may not be required to label products that contain gluten.
What is Gluten?
Gluten is the main protein that is found in many grains such as wheat, rye, and barley. It is formed by two proteins which are glutenin and gliadin. And the word �gluten� is Latin for �glue� and when mixed with water, it rises and stretches. Most gluten can be found in some bread, pasta, cereal, and beer.
But in this article, we are going to inform you 8 products that have hidden gluten. Because here at Injury Medical Clinic, we take the time to talk with our patients on what ails their bodies and work on discovering what kind of food allergen or food sensitivity they may have. As well as, finding alternatives to prevent inflammation in their bodies.
8 Products with Hidden Gluten
Medications: Yes, you�ve read that correctly, there is gluten in medication. Surprisingly though, a lot of prescription medicine contains excipients (containing gluten) that actually binds the pills together. This is mostly found in generic over the counter medications but the labeling for the ingredients are not always there.
However, labeling standards are changing due to the Gluten in Medicine Disclosure Act of 2019. This was proposed on April 3, 2019, and introduced by Representatives Tim Ryan (D-OH) and Tom Cole (R-OK). The bill�s intent was to make it easier to identify gluten in prescription medicine and it is telling drug manufacturers that it is required to label medications with the list of their ingredients, their sources and whether the gluten compound is present.
Hopefully with enough signatures and votes that the bill will be passed, however, if you are taking medication and the labels look different; always verify with a pharmacist to see if it is correct. Plus, you can always talk with your pharmacist to confirm that your medicine is gluten-free, so that way you won�t get a bad reaction from it.
Sauces and gravy: Everybody loves any sauces and gravies in the meals they prepared and are excellent in mash potatoes and Thanksgiving dinners. But sauces like soy or teriyaki do contain wheat protein, hydrolyzed wheat starch or wheat flour. While others sometimes contain soy sauce or malt vinegar.
In any recipe that contains a type of sauce for the food you are preparing, especially in creamy sauces and gravies, mostly requires a roux; which is wheat flour mixed with butter. So, whenever you are at your favorite restaurant or have a favorite meal to prepare, get familiar with the sauces, so that way you can know that if they are gluten-free or not.
Starches: When we think of starches, our minds go to the potatoes. However, wheat can also be found in starches and starch derivatives. So, whenever you are looking at products that are starchy, look at the ingredient labels and for terms like �wheat starch�, �hydrolyzed wheat starch�, or �contains wheat.�
In order for starches that contain wheat starch to be gluten-free, the wheat compound must remove to less than 20 ppm. And especially in FDA regulated food labels, if the product says �contain wheat�, it is not safe. But food labels don�t apply to barley, rye, or oats, still continue to read the ingredient labels in the case for the wheat compound and if it is not there then the product is safe. For gluten-free starches for those who don�t want to miss out, tapioca starch, rice starch, and potato starch are perfect for frying.
Brown Rice Syrup: This type of sweetener is made from fermented brown rice with enzymes or from barley, which breaks down the starch and transforms it into sugar. Sadly though, this sweetener is not gluten-free and it can be used on its own or be used as an ingredient in a multi-ingredient product. Some companies use brown rice syrup in their products by listing it as �barley� or �barley malt.� And it is a bit problematic for those who have a gluten allergen to this sweetener.
Soups: Who doesn�t love soups. Soup is there for us when we are sick and for comfort when it gets really cold in the fall and winter seasons. But companies use wheat flour or wheat starch as a thickener for those creamier soups that we love in a can and those thickeners can be hidden in the ingredients label. So, if you want pre-packaged soup bases and canned soups for those colder seasons, be sure to read the labels carefully, especially for those creamed-based soup bases and bouillons because they might contain gluten.
Salad dressings: Did you know that many standard salad dressings can wheat flour, soy, or malt vinegar? Not only that but it can contain wheat or gluten-containing additives as a thickener. Plus salad dressings often have artificial colors, flavorings and many other additives that can contain gluten as a sub ingredient. However, if you want to be safe and not have gluten in your salad dressings, simply put in olive oil, lemon, salt, and pepper, and you got yourself a gluten-free salad dressing.
Chips and fries: Chips and fries are the staples for a good burger or hot dog on every barbeque events and parties. Yes, the potato that makes the chips and fries are gluten-free; but the seasonings like malt vinegar and wheat starch do contain gluten. And when we are frying cut potatoes into French fries and chips; the oil that is used to make them can be cross-contaminated with gluten-containing fried foods.
Processed meats: Meat is most likely to be the last place you think that has gluten. However, processed hamburger patties, meatballs, meatloaf, sausages, and deli meats contain gluten. Wheat-based fillers are used to either improve the texture of the meat or bind the meat together. Plus, seasoned or marinated eats can sometimes contain hydrolyzed wheat protein or soy sauce with breadcrumbs are added to bulk up the product.
Conclusion
So if you are at the grocery store getting some food for dinner or meal prepping, it is important to actually read the labeling of the products that you are buying. Whether you have a food allergy or food sensitivity to gluten or any food products, we here at Injury Medical Clinic, listen to what is causing our patients pain to their bodies and offer solutions to fix whatever ailments that the problem is causing.
Sleep and weight are like a double edge sword. Less sleep will cause you to gain weight and gaining weight will cause you to sleep less. Since everyone wants to get a better night sleep, we need to cut those tight bonds so that our overall health and mental state to improve.
Less Sleep= More Weight
With our busy fast-paced lives, we tend to take on more commitments than we want. As well as, being stressed all the time. This lifestyle is not good for our bodies when we want to have a better lifestyle. In our previous article, lack of sleep can lead to chronic illness and loss of productivity. Not even that, Japan hold the number one spot of less sleep with 5 hours and less; while the U.S. holds the number two spot with 6 hours and less.
So, when we don�t get enough sleep due to causative factors, two major hormones in our body are affected and not in a good way either. It is our pituitary glands and our hormonal cortisol that get affected when we don�t get the recommended seven to eight hours of sleep. Our pituitary glands are the master controller to all our hormones and are sensitive when we don�t get enough sleep. When we actually get the recommended seven to eight hours of sleep, our pituitary glands release our growth and thyroid hormones as well as suppressing the stress hormone cortisol.
But in today�s society, according to the National Sleep Foundation, the average American sleeps only about seven hours per night-while other sleep five to six hours per night on a regular basis. With these studies, our body will be more or less in a constant state of partial sleep deprivation. Or if you have an anxious mind or have mental health issues, partial sleep deprivation can lead to chronic sleep deprivation. Chronic sleep deprivation can lead to elevated cortisol in the evening, a crucial time for the levels should be diminishing.
Cortisol Levels
When our cortisol levels get too high, we can develop insulin resistance, thus leading to weight gain and the high risk for type 2 diabetes. Chronic sleep deprivation can also change your growth hormone release. Instead of sending out one large pulse of growth hormones as soon as our heads hit the pillow, our bodies send out two small pulses, one before we go to bed and one after, thus leading us to have sleep deprivation. The one large pulse is responsible for the exposure of our tissues and reducing our glucose tolerance.
When we don�t get enough sleep throughout the day, the fat cells can�t handle the insulin in our bodies and will drop as much as 30 percent. When our cells resist insulin in our bodies, our blood sugar goes up and the excess sugar we produce is stored in our bodies as fat. This is dangerous to our health because not only we will gain the weight, but we will be at the risk for type 2 diabetes, high blood pressure, heart disease, and cancer. According to the CDC, 11.1 percent, adults who snooze less than 7 hours per night have type 2 diabetes, while 8.6 percent of adults who snooze more than 7 hours per night may already have the disease.
Late Night Munchies
One study stated that, people who snooze less tend to be heavier than people who sleep the recommended amount. The study looked at the younger age group and discovered that short sleep duration appears independently associated with weight gain. And the CDC also stated, 33 percent of adults who snooze less than 7 hours are obese, while 26.5 percent of adults who sleep more than 7 hours are obese as well. But the question still remains, why do we gain more weight when we snooze less?
The answer is that our hormones are the ones that get affected the most when we don�t get enough sleep. Hence why we get the late-night munchies. When we are supposed to get our full 8 hours of sleep, our bodies release hormone leptin, which regulates how satiated we feel, and releases hormone ghrelin, which stimulates our appetite. So, when our hormone leptins go down and ghrelins go up, our minds think that we are very hungry and that we need to get up to satisfy that hunger with carbohydrates, thus making us loose those few extra minutes of sleep. So, it�s not your willpower that is making you wake up to eat at around 2 a.m., it is your lack of sleep that is causing the imbalance in your body.
More Weight= Less Sleep
Like we stated in the beginning, sleep and weight are like a double edge sword. Being overweight or obese can keep you from getting enough sleep as well. There are some weight-related issues like, sleep apnea, COPD (chronic obstructive pulmonary disease) and arthritis that can be an issue from getting those recommended snoozes.
Sleep apnea is very common for obese or overweight adults. When we have sleep apnea, our airways collapse or is blocked when we snooze. Our breathing gets very shallow or even stop while you sleep and can last for a few seconds to a couple of minutes or even longer.
We do wake up with a choking noise or snort then we go back to sleep, but when it�s the day time we are at risk for daytime sleepiness. Sleep apnea can be treated with breathing devices but major lifestyle changes can help you lose this medical condition.
When you are suffering from COPD, you will notice a shortness of breath and have more trouble sleeping. People with COPD may be overweight or obese can actually exercise to combat this condition. However, you must consult with your doctor if you want to change your lifestyle and fix this condition.
Painful, arthritic joints can keep you up at night. Granted that there are anti-inflammatory and pain medication that may help you sleep; but if you are overweight or obese taking those medications, they will add on more problems like digestive discomforts or a dependence.
Conclusion
Here at Injury Medical Clinic, we do consult with our patients about the importance of exercising and eating healthy to assist whatever ailments they may have. Whether it is stress or medical conditions, we strive to make our patients feel good.
In conclusion, sleep is highly important and should be on the top of the list for a better lifestyle as well as placing weight in second. Granted with our busy work schedules, and fast-pace lifestyles, we ignore sleep and we gain the weight. If you have any sleep conditions like COPD or sleep apnea, please seek professional help to get it under control. But if you change your lifestyle a little bit by eating right, focusing on mental health, exercising, and sleeping at the appropriate times; not only your mood changes but your body will heal tremendously and you will feel like you can conquer the world.
The Most Effective Chiropractor | El Paso, Tx (2019)
Neck pain and back pain are common symptoms which can develop because of sports accidents, automobile crash injuries, and a variety of other wellness issues. Painful symptoms can ultimately impact an individual’s daily physical activities, tremendously affecting their well-being. Patients clarify their neck pain and spine pain symptoms improved after they visited Dr. Alex Jimenez. Chiropractic care focuses on the diagnosis, therapy, and prevention of a variety of injuries and/or aggravated conditions associated with the musculoskeletal and nervous system. Patients highly recommend Dr. Alex Jimenez and his team as the non-surgical alternative for neck pain and spine pain related to sports injuries, auto accident injuries, and other health problems towards pain relief.
NCBI Resources
Chiropractic can help you sleep. In fact, one-third of people who undergo chiropractic adjustment report sleeping better immediately, according to the�National Sleep Foundation. The benefits are not just for adults � 40 percent of infants slept better after just one chiropractic session. That is good news, considering one-fourth of babies experience sleep problems and when babies don�t sleep, nobody else in the house sleeps either!
The microbiome is a crucial part of the body and how effectively it functions.� The microbiome plays a significant role in the immune system, the digestion of food, how the body metabolizes drugs, detoxification, vitamin production, as well as protection from foreign innovators. However, just like many other parts of the human body, it is greatly influenced by stress, environmental factors, and sleep which can ultimately impact intestinal permeability.
Ideally, the best functioning microbiome is diversified. The more diversity a microbiome has, the more stable and resilient to antibiotics it becomes. In addition to this, a diversified microbiome also has stronger pathogen resistance.
The microbiome is filled with many different bacteria strains that all play essential roles in keeping the gut healthy and controlling intestinal permeability.
Bacillus is a spore-forming bacteria whose major role is the production of B and K2 vitamins in the gut.
Clostridia compromise about 10-50% of the microbiome and are anaerobes that are not found in probiotics. These thrive on high fiber and polyphenols.
Akkermansia makes up 1-3% of the microbiome and helps to reduce inflammation and protect against inflammatory bowel disease.
Lipopolysaccharides are bound on gram negatives residing in the gut and protecting the bacteria from bile salts. (Lipopolysaccharides are normal in the gut, but they are not normal in the bloodstream)
The main reason it is important to have a diversified and healthy gut is to avoid problems with intestinal permeability or “leaky gut syndrome”.� A leaky gut refers to how easily substances that are not fully digested pass through the intestinal wall. This occurs when the tight junctions of the walls become loose, allowing the gut to be more permeable.� This is how bacteria and toxins pass from the gut into the bloodstream, causing inflammation and other autoimmune diseases.
Keys to a healthy gut:
Eat more organic fruits, vegetables, and fermented food
Try to limit the amount of food that is boiled as boiled foods contain fewer polyphenols
�Supplements such as Vitamin D, Vitamin C and Omega 3’s
Detox: sauna, yoga, meditation, and regular exercise
Prebiotics and Probiotics
It is important to remember that the best thing for a healthy gut is diet. Suppliments and pills can help, but in the long run, a diet is the most important and influenctial factor to the gut. A gut healthy diet will aslo help to maximize liver detoxifaction. If you do not know where to begin, I recommend getting a gut zoomer blood test and consulting with a doctor about what probiotics and diet are best for you. – Kenna Vaughn, Health Coach�
Now and days, mostly everyone has a gluten sensitivity or a gluten allergen in their bodies. This could happen to anyone whenever they are eating gluten-contained food or products and suddenly feel unwell or their gut acts differently throughout the day. Or they actually get tested by their physicians and realizes that they have celiac disease. In the last article and the previous one after that, we talked about the 8 products that have hidden gluten in them; as well as the introduction of the wheat zoomer we use for our patients.
Here at Injury Medical Clinic, Dr. Alexander Jimenez consults with our patients about certain zoomers that can actually aid the patient�s body. In this article, we review the factors that affect test results such as medication and fasting after taking the Wheat Zoomer, as well as, focusing heavily on the mechanism of the intestinal permeability, the structure and function of the epithelium. We also focus about important immunomodulatory metabolites, epithelial cell types and the roles in the epithelial barrier.
Intestinal Permeability
Let�s start with the mechanisms of intestinal permeability. The main purpose of the intestinal epithelium is to keep the good things in and the bad things out. While the system is complex and ever changing, it still sends out a message to the host and maintain balance both physical and biochemical as a protective barrier.� There is an abundance of antigen sampling to regulates the flow of nutrients in the host�s body, as well as, keeping an eye on the body by the mucosal immune system. Not only that, if you have an injury or an acute inflammation, the intestinal epithelium will support tissue repair by coordinating with microbiota.
Another thing that the epithelium does is that it responds to the microbial signals that will make our bodies tolerate any continuous exposure to commensal bacteria. But we do want to keep the good bacteria in our bodies but get rid of the bad bacteria, so our bodies feel good. The intestinal epithelium also convey microbial signals to the mucosal immune cells, while promoting a coordinating immune response to battle against commensal bacteria and the enteric pathogens, since these two microsomes should not be in places they are not allowed in.
While the epithelium is battling with the bad bacteria in our system, it also regulates the B and T cell response to either, control inflammation, squash inflammation, or cause inflammation on the intestinal barrier, depending on the situation. Plus the epithelium locally regulates the immune response at the intestinal barrier by influencing innate and adaptive immune responses to the body�s intestines.
However, if there is something disrupting the intestines, like chronic inflammation or leaky gut; the epithelium barrier can be compromised. In order for us to fix a leaky gut, we must learn what is causing the inflammation in the first place. The epithelium is home to many microbes, immune cells and can determined if we need the immune response on any harsh exposure. If we can learn more about these mechanisms, then we can calm down the inflammation by resetting it back to its calm, natural state.
But the immune cells in our intestinal epithelium can also cause disruption on our gut by leaking out of the protective barriers and attacking the pathogens anywhere in our system. So epithelial permeability can not only cause inflammation but prevent it in our intestines, which is both good and bad depending on the situation.
Dr. Alexander Jimenez consults with our patients with natural alternatives of healing inflammation in their gastral intestines.� If he can find the sources of what causes the inflammations in your gut, then he can work with aiding them with functional medicines while informing you what they can do to heal your gut.
Now let�s looks at the intestines and the many microsomes that they contain. Here are some microsomes we will be discussing as well as what is their key roles in the intestines; so we can figure out how to prevent a leaky gut.
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The Mucosa
This is in both the small intestines and the large intestines and are completely different. The small intestines has one mucus layer and has limited microbes inside it�s mucosa, while the large intestines has an attached inner mucosa and a loose outer mucosa. The mucosa plays an important role in the intestines because it can tell �Friend� from �Foe� in the immune system.
Important Tight Junction Proteins
The tight junction is an important function in the intestinal epithelium as it is one of the barriers that separates what comes in and what comes out in our gut.
Actin: Are the structure and functions of tight junctions. But they constantly disassemble and reassemble actin filaments if they are anti-Actins. It is controlling the tight junctions cells as it acts like a contractable belt by pulling or contracting the junctions in the intestinal cells.
Zonulin: They are the �gatekeeper� proteins that are responsible for opening or closing the tight junctions. Zonulin acts the mortar of the intestines and is associated when gluten sensitivity is present, if there are low counts of zonulin thus causing inflammation.
LPS(Lipopolysaccharide): These sent out a signal to the tight junction permeability as they find signs of bacterial endotoxin by translocating across the epithelial barrier and entering circulation. LPS is made up of gram negative bacteria in the GI tract. LPS outside the epithelial cell wall and reacts to fatty acids, which can lead to obesity for individuals.
Cell Receptors Involved in the Barrier Integrity
These cells are protectors of the epithelial barrier walls as they strengthen the immune intolerance and digestive tract, as well as causing or preventing inflammation when necessary.
G Protein Coupled Receptors (GPCRs): GPCRs are the main players of the immune system in the epithelial system. A wide variety of substances can bind with GPCRs depending what the substances are. Short chain fatty acids, omega-3�s and any food that we eat is fermented by our gut and stimulate repair on the epithelial barrier. However if there is a consumption of low or zero-fiber in our diet, the food will not be fermented and causes inflammation.
Aryl Hydrocarbon Receptors (AhRs): AhRs interact with a range of aromatic hydrocarbons like food and microbes both in and out of the gut. These receptors respond strongly to compounds found in cruciferous vegetables, thus preventing a heighten immune reaction and reducing epithelial damage as well as promoting functioning intraepithelial lymphocytes (IELs).
But if we are not eating enough cruciferous vegetables, the IELs are being produced less, the epithelial barrier is compromised and will cause inflammation.
Bile Acid Receptors (BARs): BARs recognize primary and secondary bile acid. The primary bile acids comes from the liver and then transformed into secondary bile acids by microbes. BARs play an important role in in metabolic regulation, however if there is suppression of bile in the GI tract; then the intestinal barrier is more susceptible to destruction. However, if you are producing a low bile count or obstructed bile flow, it can be the result of the microbes translocating to the small intestines and causing mucosal inflammation, SIBO and leaky gut.
Epithelial Cells Involved in the Barrier Integrity
These cells are very important to the intestinal epithelial barrier as they can either protect the barrier walls or can lead them to their demised.
Dendritic cells: Dendritic cells are presenting antigen cells that are found the epithelial layer. These cells sample and present antigens it to Tcells, thus activating immune response. Dendritic cells help the Tcells tell the difference between self and non-self because if we eat commonly consumed foods or foreign antigens are present, we don�t want our immune system to rise up�most of the times.
Goblet cells: Goblet cells are very important of the epithelial barrier because they provide the mucus barrier that coats and protects the intestinal walls. Without this mucus barrier, we will sick and any harmful bacteria will come in and out of the intestinal barriers.
Enteroendocrine cells: Enteroendocrine cells host receptors and produce a wide range of hormones, enzymes and neurotransmitters that affect or control our appetite, digestive functions, motility and interacts with microbial communities. However, these cells can either be beneficial or not if the host diet is in played.
M cells: Microfold cells or M cells are located over the Peyer�s patches and they constantly sample outside the intestinal epithelial barriers for any microbes that pose a threat. They also present antigens from the outside to the dendritic cells to activate the Tcell response, as well as consuming the antigen by neutralizing it. Without the M cells, we risk of losing tolerance to microbes, thus causing inflammation on our intestinal barriers.
Conclusion
In total, we now have a deeper knowledge of our gut system as well as taking an in depth look on what our intestinal gut goes through to stop inflammation. In order to stop leaky gut, we must change our eating habits gradually when we want a healthier life. Dr. Alexander Jimenez does discuss to our patients the importance of protecting our gut with functional medicine as well as, encouraging our patients to take that first step into a healthy lifestyle.
Ah� the bathroom, nature�s thinking room. The one place where we create many thoughts that turn into ideas, a place to read, and the place where we want peace and quiet. Known as many different names,� the bathroom is the one place where we flush out our systems after consuming quantities of food. However, did you know that the bile inside your body plays a huge important role in our system?
Bile is a vital body fluid that absorbs nutrients in our small intestines and flushes the toxins out of the liver. Bile continuously is being produced in the liver and then stored in the gallbladder. It also works as a signal molecule for both inside and outside the liver as well. When the liver and bile is disruptive, it can cause many problems for the body.
TCM (Traditional Chinese Medicine) stated that the liver is known as the �master organ� and it is the causative factor in many of the body�s ailments. When there are major imbalances on our bodies, it causes liver dysfunction. In TCM, the liver actually helps with detoxification; enzyme, hormone, and bile production, immune cell activation and stores vitamins and iron.
How Does the Liver Work?
The liver�s main job is to get rid of bile in our internal system. Not only that but the liver plays an important role by distributing nutrients by converting those nutrients into metabolizing energy. As well as storing vitamins and minerals for later use.
However, in today�s fast-paced society, the liver can�t perform right as we don�t give the liver it�s essential nutrients that it needs to function. Which causes blockage in the gallbladder, diseases, and digestive issues.
The Importance of Bile
As stated, bile has many functions that play an important part in the liver. Bile actually lubricates our small intestines and stool for easy disposal. But when there is less lubrication in our small intestines and stool, it can lead to constipation and too much lubrication can lead to diarrhea.
There is also a chance of blockage in bile where it can increase the accumulation of toxins in our body which creates oxidative stress and back up our waste matter. When we eat too much food and it�s still in our intestines, it will ferment and causes a leaky gut as toxic gasses penetrate the intestinal lining.
Another function is that the bile salts break down and processes fats that are essential for weight loss. Bile can also transport toxins out of our liver to feces while keeping everything free-flowing. When there isn�t enough bile being produced, cholesterol stones are forming.
Vitamins like, vitamin A, D, E and K can break down the excess fat in the body if there is an adequate amount of bile. But if patients had gallbladder surgery must be taken to account that they don�t have a bile storage system, and must manage their bile production.
Liver Functions for Hormonal Balance
Did you know that the liver and thyroid have a synergistic relationship? That�s because the T4 is converted to T3 for the liver. It turns out that the T3 is more potent in the thyroid hormone and is metabolized from iodine. When a patient has a thyroid problem, it could actually be the result of a bile or liver malfunction.
When our mood and mental state is imbalanced, it can be the results of a sick or fatty liver. Due to the fact that the liver influencing on our hormones. Because our mental state and our moods correlate to our hormones, it is important to keep the liver healthy but also finding a good place in our state of mind to make sure that we keep our liver healthy as well.
Signs of Liver Imbalance
There are many symptoms that can cause the liver to be imbalanced and can contribute to a low bile count:
Now that we understand what symptoms that causes our liver to be imbalanced, here are 5 ways to make sure that you are protecting your liver and producing a healthy amount of bile.
Removing Causative Factors
The first and foremost factor in protecting your liver is to get rid of the causative factors that are harming your liver. Things like an excessive amount of lactate in coffee, sugars, alcohol, and processed foods can disrupt your liver�s health. It�s ok to enjoy those things sparsely but, if you are trying to maintain a healthy liver, it�s best to ease up on the consumption of those lactate factors as much as possible.
Eating Liver Supportive Foods
There are many foods that actually help support the liver. Grapefruit, blueberries, cranberries, prickly pears, and bitter greens are just some of the foods that can actually help your liver and bile production. We here at Injury Medical Clinic, always inform our patients the importance of whole nutritious food to heal and repair what ailments in our patient�s bodies.
Practicing Deep Breathing Exercise
Practicing deep breathing exercises have been known to lower stress and diaphragmatic breathing exercises is no exception. Since the liver is positioned below the diaphragm, when we do any deep breathing exercises; these motions actually massages our liver and stimulate bile production. Hence why singers do these exercises when they are getting ready to perform. They are massaging their liver without even knowing it.
Intermittent Fasting
Since we now know that bile is continuously being produced in the liver and being stored into the gallbladder when we are not eating, intermittent fasting is a good way to increase the bile production in the gallbladder. Plus it has been known for weight loss and beneficial for the body to heal while getting rid of the junk in our cells.
Stress Less
Stress is one of the huge factors that can either cause our body to improve our immune system or causes the body to chronic illness. Emotional stress is known to cause a huge burden to our organs because it is tied to our hormones. When we get emotionally stressed, our liver cannot get rid of the excess toxins and hormones.� So we have to find ways to de-stressed ourselves so we won�t hurt our organs, especially the liver.
Conclusion
So when it comes to our liver, we must make sure that the bile that we are producing is turning into energy all the way to feces. So, when we have to go to the bathroom we can let out the toxins naturally without any complications. If we can lower the factors that are causing us to have an inadequate bowel movements, then we can improve our body�s ability to detoxify.
NCBI Resources
Western diets, high in sugar and fat, cause liver inflammation, especially in males, according to a new animal study in�The American Journal of Pathology. Inflammation was most pronounced in males that lacked farnesoid x receptor (FXR), a bile acid receptor.
One of the most recognized running injuries is runner�s knee. However, runner�s knee is not an injury but a result of different injuries. Running can hurt when improper mechanics, inadequate shoes, and cheap over the counter insoles are being used. It can lead to:
Plantar fasciitis
Achilles tendonitis
Medial tibial stress syndrome
Metatarsalgia
Runner�s knee
Runner�s knee is not an actual injury in of itself
It�s a broad description of knee pain caused by other knee injuries, which include:
Iliotibial band syndrome
Patellofemoral pain syndrome (PFPS)
Chondromalacia patella
This can keep runners sidelined, annually.
Runner�s knee is caused by usually one of two things: poor biomechanics and overuse.
Feet are the foundation of the body and if not taken care of, pain
Feet are 99% normal at birth.
Then life takes over and issues begin to arise.
8% develop foot conditions, then�by age 5 that number jumps to 41% and 80%� at twenty.
By forty pretty much everyone has a foot condition or some type of foot pain from work and activity.
These foot issues then begin to set up problems for the rest of the body, especially the generalized condition of back pain or leg/knee/hip problems.
Being able to foresee and realize a potential problem with the feet can PREVENT other injuries from beginning to present themselves and dodge any issues that can affect health and lifestyle.
Runners who are able to avoid injury are those that land the lightest, much like a cat and sustain the lowest level of impact.
Runners think about landing softly and adjust their stride so they land closer to the midfoot.
However, it’s easier said than done.
Most runners tend to be heel-strikers
Runners with excessive pronation that try to change to a forefoot strike pattern are more prone to inner foot and ankle injuries,
And runners with high arches that try to change to a forefoot strike pattern end up with sprained ankles and metatarsal fractures.
Runners try to treat the pain with stretches or exercises that target the area, but the source of the pain is actually elsewhere and they don’t realize it and are treating the wrong area.
A lot of the time the source of the imbalance comes from the feet.
An overlooked option for reducing knee injury and pain is the use of custom orthotics.
Custom orthotics align and support the foot/ankle in a more normal physiologic position for weight-bearing, which prevents dysfunction and improves the function of the body as a whole.
What they do is:
Make a symmetrical foundation that blocks pronation and supports supination
Give the heels shock absorption
Stops serial stress throughout the body
Enhances re-educating muscle-memory
Custom-made orthotics help reduce the impact of heel strikes when running or walking.
Shock absorption is a must when there is
Instability
Chronic degeneration
Inflammatory arthritis
Orthotics that are designed specifically to cushion the impact load from running can reduce pain triggers throughout the body.
Avoiding knee injuries
When orthotic care is indicated, custom-made functional orthotics can help reduce pain.
Look for orthotics that support the running gait and
Absorb shock at heel-strike
Support mid-stance
Provide propulsion at toe-off
Excessive Foot Pronation can Affect *FOOT POSTURE & MOBILITY* | El Paso, TX (2019)
The following video discusses how excessive foot pronation can ultimately have an effect on foot posture and mobility. Several things can impact foot posture and mobility, such as excessive foot pronation. Excessive foot pronation is most widespread among the overall populace, therefore, it’s regarded as one of the most frequent factors for abnormal foot posture and mobility, which can lead to a variety of health issues like overuse injuries. Excessive foot pronation and supination can ultimately impact general health and wellness.
What’s Afoot
Misalignment can be caused by many common runners� experiences including running on the same type of surface every day, running on a slanted surface such as a beach or replacing running shoes too infrequently. As a runner, you can work to vary your running surfaces and keep a better watch on your shoes, but your chiropractor will let you know if your body is in need of more balance.
NCBI Resources
If you are an active amateur or a competitive runner, using the services of a chiropractor can make a vast change in your overall health, reduce your pain from injuries and improve your alignment for a more effective run. Runners may not even realize that the tension they feel is the beginning of pain caused by being out of balance until it is adjusted. Chiropractic adjustments are often part and parcel of a runner�s training program to strengthen and improve performance. They can also help�recover from pregnancy�and postpartum bodily changes.
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