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How Fasting Affects Digestive Health in Functional Neurology

How Fasting Affects Digestive Health in Functional Neurology

Our digestive health depends on the composition of our healthy gut microbiome or the bacteria in our gastrointestinal (GI) tract. This probiotic profile plays a fundamental role in our immune system and these can ultimately affect our inflammatory response. Also, the foods we eat, hormones, neurotransmitters, and even our adrenal and mitochondrial status can influence our digestive health. Abnormal or excess bacteria can cause many digestive health issues. Researchers and healthcare professionals have found that “fasting” can help promote a healthy gut microbiome and support overall digestive health. �

 

Several studies have shown that consuming enough fiber and foods that increase the amount of bacteria in the gastrointestinal (GI) tract is associated with improved insulin sensitivity as well as reduced immune reactions and inflammation, among many other health benefits. These same studies also demonstrated that fasting can have these same health benefits. Different types of fasting can be used as a treatment approach for a variety of digestive health issues. As a matter of fact, other studies have shown that fasting can help improve digestive health issues like SIBO, IBS, and leaky gut. �

 

An Experiment on Fasting and Digestive Health

Mike Hoaglin, former clinical director for the Dr. Oz show and current clinical lead for uBiome, a biotechnology company that helps healthcare professionals and patients understand how the gut microbiome affects overall health and wellness, demonstrated the importance of the bacteria in our gastrointestinal (GI) tract by sharing the outcome measures of an experiment he tried on himself. Biotechnology companies like uBiome can determine a patient’s probiotic profile, including “healthy” and pathogenic microorganisms which may be associated with digestive health issues like Crohn’s disease and ulcerative colitis. �

 

After learning how fasting can help improve your immune system, activate stem cells, and reduce your risk of developing many types of cancers, Mike became motivated to do his own five-day water fast to see how this strategic way of eating would affect his gut microbiome. He was also inspired to know how fasting could affect his energy levels as well as his mental acuity and brain fog. By submitting a stool sample, he determined the spectrum of bacteria in his gastrointestinal (GI) tract before starting the fasting process. Mike Hoaglin was under the supervision of his functional medicine practitioner. �

 

Understanding the Effects of Fasting

According to his uBiome probiotic profile test results, Mike had dysbiosis, an imbalance in the composition of his gut microbiome associated with decreased biodiversity of “healthy” bacteria and increased “harmful” bacteria known for causing inflammation. Mike Hoaglin scheduled five days in his schedule to start the fasting process after he talked to his functional medicine practitioner. As many people have described during the first several days of fasting, Mike had a very difficult time going without eating any food. He described feeling cranky and hungry, however, he was still able to sleep. �

 

Mike’s hunger had thankfully subsided by day three of the fasting process and, although he still had several days left of the treatment approach, the understood that the rest of the fasting process wasn’t going to be as challenging as it had been for the first two days, despite his blood glucose, or sugar, being low. Mike Hoaglin felt an increase in his energy levels by day four of the fasting process. He felt more mental clarity as his digestive system started using fat as energy instead of using sugar, or glucose. He immediately recognized that his stem cells had activated during day four of the fasting process. �

 

Mike ended the fasting process on day five at 5:00 pm by consuming a cup of bone broth. Bone broth is one of the most recommended type of foods to help people transition from fasting because it has essential amino acids, such as glutamine and glycine, that provide nutrition to the gastrointestinal (GI) tract as soon as it starts digesting food once again. Moreover, adding some Himalayan salt to your bone broth can also provide your cells with added minerals. Mike continued to transition from fasting by eating fiber-rich plant foods, healthy fats, and small amounts of lean protein, in easily digestible variations. �

 

Mike Hoaglin tested his gut microbiome following his fasting process and he was pleasantly surprised with the outcome measures of his probiotic profile. According to the uBiome test, fasting had practically “reset” Mike’s gut microbiome, or the bacteria in the gastrointestinal (GI) tract. The results demonstrated a balanced composition of his gut microbiome and he had increased the biodiversity of “healthy” bacteria and decreased “harmful” bacteria. After completing his experiment, Mike Hoaglin became more aware of how the type of foods we eat can ultimately affect our digestive health. �

 

Dr. Alex Jimenez Insights Image

Fasting is a well-known, strategical way of eating which can have a variety of digestive health benefits for many people. Many people can tremendously benefit from fasting. Fasting can activate autophagy, or the natural cellular detoxification process, to help sweep excess bacteria and undigested food debris away for elimination as waste, also activating anti-inflammatory processes to reduce inflammation and oxidative stress. During an experiment, fasting was shown to have tremendous benefits on overall digestive health. However, it’s important to keep in mind that fasting may not be for everyone. Make sure to talk to a qualified and experienced doctor before attempting any fasting approaches. – Dr. Alex Jimenez D.C., C.C.S.T. Insight

 


 

Neurotransmitter Assessment Form

[wp-embedder-pack width=”100%” height=”1050px” download=”all” download-text=”” attachment_id=”52657″ /] �

 

The following Neurotransmitter Assessment Form can be filled out and presented to Dr. Alex Jimenez. The following symptoms listed on this form are not intended to be utilized as a diagnosis of any type of disease, condition, or any other type of health issue. �

 


 

Our digestive health depends on the composition of our healthy gut microbiome or the bacteria in our gastrointestinal (GI) tract. This probiotic profile plays a fundamental role in our immune system and these can ultimately affect our inflammatory response. Also, the foods we eat, hormones, neurotransmitters, and even our adrenal and mitochondrial status can influence our digestive health. Abnormal or excess bacteria can cause many digestive health issues. Researchers and healthcare professionals have found that “fasting” can help promote a healthy gut microbiome and support overall digestive health. � Several studies have shown that consuming enough fiber and foods that increase the amount of bacteria in the gastrointestinal (GI) tract is associated with improved insulin sensitivity as well as reduced immune reactions and inflammation, among many other health benefits. These same studies also demonstrated that fasting can have these same health benefits. Different types of fasting can be used as a treatment approach for a variety of digestive health issues. As a matter of fact, other studies have shown that fasting can help improve digestive health issues like SIBO, IBS, and leaky gut. �

 

The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.�

 

Curated by Dr. Alex Jimenez �

 

References:

  • �The Impact of Fasting on Your Microbiome.� Naomi Whittel, 12 Mar. 2019, www.naomiwhittel.com/the-impact-of-fasting-on-your-microbiome/.

 


 

Additional Topic Discussion: Chronic Pain

Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals, however, chronic pain is different than the average type of pain. With chronic pain, the human body will continue sending pain signals to the brain, regardless if the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient’s mobility and it can reduce flexibility, strength, and endurance. �

 

 


 

Neural Zoomer Plus for Neurological Disease

Neural Zoomer Plus | El Paso, TX Chiropractor

 

Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual�s reactivity to 48 neurological antigens with connections to a variety of neurologically related diseases. The Vibrant Neural ZoomerTM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention. �

 

Food Sensitivity for the IgG & IgA Immune Response

Food Sensitivity Zoomer | El Paso, TX Chiropractor

 

Dr. Alex Jimenez utilizes a series of tests to help evaluate health issues associated with food sensitivities. The Food Sensitivity ZoomerTM is an array of 180 commonly consumed food antigens that offers very specific antibody-to-antigen recognition. This panel measures an individual�s IgG and IgA sensitivity to food antigens. Being able to test IgA antibodies provides additional information to foods that may be causing mucosal damage. Additionally, this test is ideal for patients who might be suffering from delayed reactions to certain foods. Utilizing an antibody-based food sensitivity test can help prioritize the necessary foods to eliminate and create a customized diet plan around the patient�s specific needs. �

 

Gut Zoomer for Small Intestinal Bacterial Overgrowth (SIBO)

Gut Zoomer | El Paso, TX Chiropractor

Dr. Alex Jimenez utilizes a series of tests to help evaluate gut health associated with small intestinal bacterial overgrowth (SIBO). The Vibrant Gut ZoomerTM offers a report that includes dietary recommendations and other natural supplementation like prebiotics, probiotics, and polyphenols. The gut microbiome is mainly found in the large intestine and it has more than 1000 species of bacteria that play a fundamental role in the human body, from shaping the immune system and affecting the metabolism of nutrients to strengthening the intestinal mucosal barrier (gut-barrier). It is essential to understand how the number of bacteria that symbiotically live in the human gastrointestinal (GI) tract influences gut health because imbalances in the gut microbiome may ultimately lead to gastrointestinal (GI) tract symptoms, skin conditions, autoimmune disorders, immune system imbalances, and multiple inflammatory disorders. �

 


Dunwoody Labs: Comprehensive Stool with Parasitology | El Paso, TX Chiropractor


GI-MAP: GI Microbial Assay Plus | El Paso, TX Chiropractor


 

Formulas for Methylation Support

Xymogen Formulas - El Paso, TX

 

XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.

 

Proudly,�Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.

 

Please call our office in order for us to assign a doctor consultation for immediate access.

 

If you are a patient of Injury Medical & Chiropractic�Clinic, you may inquire about XYMOGEN by calling 915-850-0900.

xymogen el paso, tx

For your convenience and review of the XYMOGEN products please review the following link. *XYMOGEN-Catalog-Download

 

* All of the above XYMOGEN policies remain strictly in force.

 


 

Functional Neurology: Fasting and Autophagy for Digestive Health

Functional Neurology: Fasting and Autophagy for Digestive Health

Scientists and healthcare professionals are starting to shine a light on the importance of the composition of our gut microbiome, or the population of “healthy” bacteria in our gastrointestinal (GI) tract. According to research studies, abnormal or excess amounts of gut bacteria can be one of the most common causes of a variety of digestive health issues, including SIBO and IBS. Our ancestors have included fermented foods like yogurt, kimchi, and sauerkraut as an important part of their traditional diet to regulate and manage the composition of their “healthy” bacteria: the gut microbiome. �

 

Finding ways to naturally improve our digestive health by maintaining a “healthy” probiotic profile has been a popular topic for many generations. As a result, eating fermented foods like those previously listed above, including other food groups with additional probiotics, and taking probiotic supplements has tremendously increased in popularity in recent years. Another way to naturally improve digestive health that has recently become more popular is fasting, strategic abstinence or reduction from several or all foods for a certain period of time. Fasting can ultimately help improve overall digestive health. �

 

Fasting can help support the healthy composition of our gut microbiome and it can be used as a treatment approach for a variety of conditions and diseases, such as headaches, migraines, eczema, metabolic syndrome, and obesity. Scientists and healthcare professionals have determined that fasting can stress the human body in a beneficial way. This stress benefits the healthy bacteria in the gastrointestinal (GI) tract because it helps activate autophagy or the natural cellular detoxification process. In the following article, we will discuss how fasting and autophagy can promote digestive health. �

 

Fasting and Autophagy Overview

Our gastrointestinal (GI) tract can often have a difficult job trying to repair our cells while sweeping undigested debris away to eliminate as waste because many people are constantly eating throughout the entire day. Many people are completely against the idea of fasting, or willingly skipping one or two meals per day, despite its benefits towards our digestive health. Because there are a variety of different methods and techniques for fasting, many people can follow this strategic way of eating and still take advantage of all its digestive health benefits. Fasting, however, may ultimately not be for everyone. �

 

Historically, many religious and spiritual practices used fasting as an important element in their culture to promote overall digestive health. There are currently a wide variety of fasting methods and techniques that are used to support natural well-being. Moreover, the treatment benefits of fasting are now being readily recognized in numerous research studies. The different types of fasting can ultimately vary from eating very little or nothing for a certain amount of time to drinking only water for a specific period of time, occasionally for up to five days, as a way to naturally improve digestive health. �

 

Intermittent fasting, a strategic way of eating that follows switching between unrestricted eating and restricted eating for a certain period of time, is one of the most common and practical fasting approaches for everyone. Scientists consider intermittent fasting to be safe and effective because you only go without eating any food for short periods of time. Research studies have demonstrated that using intermittent fasting for a total of 16 hours every day is enough to create the caloric restriction necessary to experience the benefits of fasting as well as to activate autophagy to help restore digestive health. �

 

The 5:2 diet is the strategic way of eating where a person consumes an average diet for five days and then greatly reduces their consumption of food to one-quarter of that of their normal diet for the other two days of the week. Every fasting approach is different but the purpose of abstinence or reduction from foods is to give our gut microbiome a break from digestion so they can focus on repairing our cells while sweeping undigested debris and excess bacteria away to eliminate as waste. Research studies suggest that the 16:8 diet may be the simplest fasting method or technique for people to follow. �

 

How Fasting and Autophagy Support Digestive Health

Our pancreas commonly triggers the release of glucagon when we have low blood glucose while the release of insulin is triggered to help reduce high blood glucose levels. Insulin decreases and glucagon increases during fasting which has been demonstrated to help promote improved metabolism as well as provide energy, mood changes, and weight loss. Fasting also helps promote the “healthy” composition of our gut microbiome or the population of “healthy” bacteria in our gastrointestinal (GI) tract. Scientists have associated fasting with the activation of the gene that supports overall digestive health. �

 

Optimal digestive health and “healthy” gut bacteria are important to help protect us from abnormal or excess bacteria, toxins, and other compounds that can trigger the immune system. Finally, fasting can help restore the integrity of the intestinal lining by managing inflammation that can ultimately help protect the human body against the variety of conditions and diseases associated with inflammation. The main benefit of fasting is that it can increase autophagy or the natural cellular detoxification process. With fasting, your gut health improves and you reduce your risk for a variety of digestive health issues. �

 

Dr. Alex Jimenez Insights Image

Fasting is a well-known, strategical way of eating which can have a variety of digestive health benefits for many people. Many people can tremendously benefit from fasting. Fasting can activate autophagy, or the natural cellular detoxification process, to help sweep excess bacteria and undigested food debris away for elimination as waste, also activating anti-inflammatory processes to reduce inflammation and oxidative stress. However, it’s important to keep in mind that fasting may not be for everyone. Make sure to talk to a qualified and experienced doctor before attempting any fasting approaches. – Dr. Alex Jimenez D.C., C.C.S.T. Insight

 


 

Neurotransmitter Assessment Form

[wp-embedder-pack width=”100%” height=”1050px” download=”all” download-text=”” attachment_id=”52657″ /] �

 

The following Neurotransmitter Assessment Form can be filled out and presented to Dr. Alex Jimenez. The following symptoms listed on this form are not intended to be utilized as a diagnosis of any type of disease, condition, or any other type of health issue. �

 


 

The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.�

 

Curated by Dr. Alex Jimenez �

 

References:

  • �The Impact of Fasting on Your Microbiome.� Naomi Whittel, 12 Mar. 2019, www.naomiwhittel.com/the-impact-of-fasting-on-your-microbiome/.

 


 

Additional Topic Discussion: Chronic Pain

Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals, however, chronic pain is different than the average type of pain. With chronic pain, the human body will continue sending pain signals to the brain, regardless if the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient’s mobility and it can reduce flexibility, strength, and endurance. �

 

 


 

Neural Zoomer Plus for Neurological Disease

Neural Zoomer Plus | El Paso, TX Chiropractor

Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual�s reactivity to 48 neurological antigens with connections to a variety of neurologically related diseases. The Vibrant Neural ZoomerTM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention. �

 

Food Sensitivity for the IgG & IgA Immune Response

Food Sensitivity Zoomer | El Paso, TX Chiropractor

Dr. Alex Jimenez utilizes a series of tests to help evaluate health issues associated with food sensitivities. The Food Sensitivity ZoomerTM is an array of 180 commonly consumed food antigens that offers very specific antibody-to-antigen recognition. This panel measures an individual�s IgG and IgA sensitivity to food antigens. Being able to test IgA antibodies provides additional information to foods that may be causing mucosal damage. Additionally, this test is ideal for patients who might be suffering from delayed reactions to certain foods. Utilizing an antibody-based food sensitivity test can help prioritize the necessary foods to eliminate and create a customized diet plan around the patient�s specific needs. �

 

Gut Zoomer for Small Intestinal Bacterial Overgrowth (SIBO)

Gut Zoomer | El Paso, TX Chiropractor

 

Dr. Alex Jimenez utilizes a series of tests to help evaluate gut health associated with small intestinal bacterial overgrowth (SIBO). The Vibrant Gut ZoomerTM offers a report that includes dietary recommendations and other natural supplementation like prebiotics, probiotics, and polyphenols. The gut microbiome is mainly found in the large intestine and it has more than 1000 species of bacteria that play a fundamental role in the human body, from shaping the immune system and affecting the metabolism of nutrients to strengthening the intestinal mucosal barrier (gut-barrier). It is essential to understand how the number of bacteria that symbiotically live in the human gastrointestinal (GI) tract influences gut health because imbalances in the gut microbiome may ultimately lead to gastrointestinal (GI) tract symptoms, skin conditions, autoimmune disorders, immune system imbalances, and multiple inflammatory disorders. �

 


Dunwoody Labs: Comprehensive Stool with Parasitology | El Paso, TX Chiropractor


GI-MAP: GI Microbial Assay Plus | El Paso, TX Chiropractor


 

Formulas for Methylation Support

Xymogen Formulas - El Paso, TX

XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.

Proudly,�Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.

Please call our office in order for us to assign a doctor consultation for immediate access.

If you are a patient of Injury Medical & Chiropractic�Clinic, you may inquire about XYMOGEN by calling 915-850-0900.

xymogen el paso, tx

For your convenience and review of the XYMOGEN products please review the following link. *XYMOGEN-Catalog-Download

 

* All of the above XYMOGEN policies remain strictly in force.

 


 

Functional Neurology: The Science of Fasting for Digestive Health

Functional Neurology: The Science of Fasting for Digestive Health

For many people, fasting, or the concept of willingly skipping meals for a specific period of time, may not seem like a very appealing way to improve digestive health. Because most people also eat about 3 meals a day, skipping one or two meals a day can ultimately cause them to feel moody, tired, and fatigued. However, for people with digestive health issues, such as SIBO, IBS, or leaky gut, they may already be feeling these symptoms, even after eating their 3 meals a day. In this article, we will discuss how fasting can be beneficial for some patients and how it can help improve their digestive health. �

 

Understanding the Digestive System

 

The digestive system starts the process of breaking down food from the moment we eat in order to absorb nutrients, such as vitamins and minerals. The digestive system will use approximately 25 percent of the calories we consume to even start the process of digestion. Digesting food requires tremendous effort from the human body because it alters many of its main functions and pulls many resources away from other structures to simply perform it. The immune system also activates every time we eat food in order to protect the gastrointestinal, or GI, tract from anything and everything that passes through. �

 

When fasting, however, the digestive system can start to heal and restore the human body. During a fast, the human body will utilize fat instead of sugar as the main source of energy fuel. An average person only has about 2,500 Kcal of glycogen to use as glucose for energy while the average person has about 100,000 Kcal of fat for energy. Moreover, it may take time for the human body to become adjusted to utilizing fat instead of sugar as the main source of energy fuel, which is why many people may not feel well until several days after they’ve started fasting. Fasting can also ultimately have other benefits. �

 

Inflammation

 

Inflammation is one of the main causes of a variety of chronic conditions and diseases, including digestive health issues. According to researchers and healthcare professionals, inflammation is the common cause of SIBO, small intestinal bacterial overgrowth, IBS, inflammatory bowel syndrome, and leaky gut. Environmental factors, such as toxins, processed foods, drugs and/or medications, alcohol, and food sensitivities or intolerances can all cause inflammation. Furthermore, stress can also cause inflammation and it can tremendously affect the process of digestion and overall digestive health. �

 

No food will ultimately pass through the gastrointestinal, or GI, tract during a fast. With the exception of water, fasting reduces the consumption of inflammatory compounds, further reducing inflammation in the human body. Anti-inflammatory cytokines become activated while pro-inflammatory cytokines become less active when fasting. The digestive system knows when we aren’t eating and it’ll ultimately trigger these structural and functional changes. Inflammation is also closely associated with oxidative stress. Oxidative stress and inflammation can affect our overall digestive health. �

 

Oxidative Stress

 

Fasting can help reduce inflammation and oxidative stress through our genes. Oxidative stress refers to the damage that happens to the cells and tissues of the human body when exposed to a variety of environmental factors, such as toxins. Proteins, lipids, and even the DNA of our cells can be affected by inflammation and oxidative stress, altering the structure and function of the cells. Eating antioxidants can help reduce inflammation and oxidative stress. It’s essential you make sure you consume enough antioxidants when you’re not fasting in order to prevent cell damage from inflammation and oxidative stress.

 

Fasting and the MMC for Digestive Health

 

Researchers and healthcare professionals have suggested that the development of several digestive health issues, including SIBO, IBS, and leaky gut, is associated with increased levels of oxidative enzymes as well as decreased amounts of antioxidant enzymes. However, the main source of these digestive health issues ultimately involves the gut microbiome or the bacteria in the gut. Small intestinal bacterial overgrowth, or SIBO, is a digestive health issue caused by the excess growth of the bacteria in the small intestine, eventually leading to leaky gut or intestinal permeability, among other problems. �

 

According to research studies and clinical trials, fasting can help change the population of the gut microbiome, encouraging the regulation of “healthy” bacteria. This digestive process is ultimately controlled by the migrating motor complex or the MMC. The MMC is a digestive process which regulates and maintains gastrointestinal, or GI, tract contractions throughout a period of time. The migrating motor complex helps sweep bacteria and undigested debris out for elimination as waste. Neurohormonal signals, such as somatostatin, serotonin, motilin, and ghrelin, control the MMC when eating and fasting. �

 

MMC activity triggers when we are fasting or in between meals. Once we consume food, however, nutrients like vitamins and minerals can affect the activation of the migrating motor complex, ultimately decreasing when MMC activity triggers, and essentially starting the digestive process once again. If we allow the MMC to complete its work during fasting, it can become much more difficult for food, undigested debris, and excess bacteria to stay in the gastrointestinal, or GI, tract. This is why fasting has been recommended as a treatment for SIBO. However, fasting may not be suitable for everyone. Although fasting can have a variety of digestive health benefits, make sure to contact a doctor before starting any fasting treatment plan or program. �

 

Dr. Alex Jimenez Insights Image

Fasting is a well-known, strategical way of eating which can have a variety of digestive health benefits for many people. Several digestive health issues, such as SIBO, IBS, and leaky gut, may tremendously benefit from fasting. Small intestinal bacterial overgrowth, or SIBO, is a severe health issue that causes excess bacteria to grow in the small intestine. Fasting can promote the migrating motor complex, or the MMC, to activate, sweeping excess bacteria and undigested debris away for elimination as waste, also triggering anti-inflammatory processes to reduce inflammation and oxidative stress. However, fasting may not be for everyone. Make sure to talk to a qualified and experienced healthcare professional before fasting. – Dr. Alex Jimenez D.C., C.C.S.T. Insight

 


 

Neurotransmitter Assessment Form

Neurotransmitter Assessment Form AE260 (1)

 

The following Neurotransmitter Assessment Form can be filled out and presented to Dr. Alex Jimenez. The following symptoms listed on this form are not intended to be utilized as a diagnosis of any type of disease, condition, or any other type of health issue. �

 


 

For many people, fasting, or the concept of willingly skipping meals for a specific period of time, may not seem like a very appealing way to improve digestive health. Because most people also eat about 3 meals a day, skipping one or two meals a day can ultimately cause them to feel moody, tired, and fatigued. However, for people with digestive health issues, such as SIBO, IBS, or leaky gut, they may already be feeling these symptoms, even after eating their 3 meals a day. In this article, we discussed how fasting can be beneficial for some patients and how it can help improve their digestive health. �

 

The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.�

 

Curated by Dr. Alex Jimenez �

 

References:

  • Rory. �How To Heal Your Gut With Fasting.� Chewsomegood, MSc Personalised Nutrition, 9 Aug. 2018, www.chewsomegood.com/fasting-ibs/.

 


 

Additional Topic Discussion: Chronic Pain

Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals, however, chronic pain is different than the average type of pain. With chronic pain, the human body will continue sending pain signals to the brain, regardless if the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient’s mobility and it can reduce flexibility, strength, and endurance. �

 

 


 

Neural Zoomer Plus for Neurological Disease

Neural Zoomer Plus | El Paso, TX Chiropractor

 

Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural ZoomerTM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural ZoomerTM Plus is designed to assess an individual�s reactivity to 48 neurological antigens with connections to a variety of neurologically related diseases. The Vibrant Neural ZoomerTM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention. �

 

Food Sensitivity for the IgG & IgA Immune Response

Food Sensitivity Zoomer | El Paso, TX Chiropractor

 

Dr. Alex Jimenez utilizes a series of tests to help evaluate health issues associated with food sensitivities. The Food Sensitivity ZoomerTM is an array of 180 commonly consumed food antigens that offers very specific antibody-to-antigen recognition. This panel measures an individual�s IgG and IgA sensitivity to food antigens. Being able to test IgA antibodies provides additional information to foods that may be causing mucosal damage. Additionally, this test is ideal for patients who might be suffering from delayed reactions to certain foods. Utilizing an antibody-based food sensitivity test can help prioritize the necessary foods to eliminate and create a customized diet plan around the patient�s specific needs. �

 

Gut Zoomer for Small Intestinal Bacterial Overgrowth (SIBO)

Gut Zoomer | El Paso, TX Chiropractor

Dr. Alex Jimenez utilizes a series of tests to help evaluate gut health associated with small intestinal bacterial overgrowth (SIBO). The Vibrant Gut ZoomerTM offers a report that includes dietary recommendations and other natural supplementation like prebiotics, probiotics, and polyphenols. The gut microbiome is mainly found in the large intestine and it has more than 1000 species of bacteria that play a fundamental role in the human body, from shaping the immune system and affecting the metabolism of nutrients to strengthening the intestinal mucosal barrier (gut-barrier). It is essential to understand how the number of bacteria that symbiotically live in the human gastrointestinal (GI) tract influences gut health because imbalances in the gut microbiome may ultimately lead to gastrointestinal (GI) tract symptoms, skin conditions, autoimmune disorders, immune system imbalances, and multiple inflammatory disorders. �

 


Dunwoody Labs: Comprehensive Stool with Parasitology | El Paso, TX Chiropractor


GI-MAP: GI Microbial Assay Plus | El Paso, TX Chiropractor


 

Formulas for Methylation Support

Xymogen Formulas - El Paso, TX

 

XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.

 

Proudly,�Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.

Please call our office in order for us to assign a doctor consultation for immediate access.

If you are a patient of Injury Medical & Chiropractic�Clinic, you may inquire about XYMOGEN by calling 915-850-0900.

xymogen el paso, tx

For your convenience and review of the XYMOGEN products please review the following link. *XYMOGEN-Catalog-Download

 

* All of the above XYMOGEN policies remain strictly in force.

 


 

Fasting And Cancer: Molecular Mechanisms And Clinical Application

Fasting And Cancer: Molecular Mechanisms And Clinical Application

Alessio Nencioni, Irene Caffa, Salvatore Cortellino and Valter D. Longo

Abstract | The vulnerability of cancer cells to nutrient deprivation and their dependency on specific metabolites are emerging hallmarks of cancer. Fasting or fasting-mimicking diets (FMDs) lead to wide alterations in growth factors and in metabolite levels, generating environments that can reduce the capability of cancer cells to adapt and survive and thus improving the effects of cancer therapies. In addition, fasting or FMDs increase resistance to chemotherapy in normal but not cancer cells and promote regeneration in normal tissues, which could help prevent detrimental and potentially life-threatening side effects of treatments. While fasting is hardly tolerated by patients, both animal and clinical studies show that cycles of low-calorie FMDs are feasible and overall safe. Several clinical trials evaluating the effect of fasting or FMDs on treatment-emergent adverse events and on efficacy outcomes are ongoing. We propose that the combination of FMDs with chemotherapy, immunotherapy or other treatments represents a potentially promising strategy to increase treatment efficacy, prevent resistance acquisition and reduce side effects.

Dietary and lifestyle-related factors are key determinants of the risk of developing cancer, with certain cancers being more dependent on dietary habits than others1�9 . Consistent with this notion, obesity is estimated to account for 14% to 20% of all cancer-related mortality in the United States7 , leading to guidelines on nutrition and physical activity for reducing the risk of developing cancer6 . In addition, given the emerging propensity of cancer cells, but not of normal tissues, to disobey anti-growth signals (owing to oncogenic mutations)10 and their inability to properly adapt to fasting conditions11,12, there is growing interest in the possibility that certain calorie-limited diets could also become an integral part of cancer prevention and, perhaps, of cancer treatment as a means to increase efficacy and tolerability of anticancer agents11�13.

Even though in the past decade we have witnessed unprecedented changes and remarkable advances in cancer treatment14,15, there remains a crucial need for more effective and, possibly, curative approaches for tumours but also, and just as importantly, for strategies to reduce the side effects of cancer treatments15,16. The issue of treatment-emergent adverse events (TEAEs) is one of the key hurdles in medical oncology15,16. In fact, many patients with cancer experience acute and/or longterm side effects of cancer treatments, which may require hospitalization and aggressive treatments (such as antibiotics, haematopoietic growth factors and blood transfusions) and profoundly affect their quality of life (for example, chemotherapyinduced peripheral neuropathy)16. Thus, effective toxicity-mitigating strategies are warranted and anticipated to have major medical, societal and economic impact15,16.

Fasting forces healthy cells to enter a slow division and highly protected mode that protects them against toxic insults derived from anticancer drugs while sensitizing different types of cancer cells to these therapeutics11,12,17. This discovery implies that a single dietary intervention could potentially help address different and equally important aspects of cancer therapy.

In this Opinion article, we discuss the biological rationale for using fasting or fasting-mimicking diets (FMDs) to blunt TEAEs but also to prevent and treat cancer. We also illustrate the caveats of this experimental approach18,19 and the published and ongoing clinical studies in which fasting or FMDs have been applied to patients with cancer.

Systemic & Cellular Fasting Response

Fasting leads to changes in the activity of many metabolic pathways associated with the switch into a mode able to generate energy and metabolites using carbon sources released primarily from adipose tissue and in part from muscle. The changes in the levels of circulating hormones and metabolites translate into a reduction in cell division and metabolic activity of normal cells and ultimately protect them from chemotherapeutic insults11,12. Cancer cells, by disobeying the anti-growth orders dictated by these starvation conditions, can have the opposite response of normal cells and therefore become sensitized to chemotherapy and other cancer therapies.

Systemic Response To Fasting

The response to fasting is orchestrated in part by the circulating levels of glucose, insulin, glucagon, growth hormone (GH), IGF1, glucocorticoids and adrenaline. During an initial post-absorptive phase, which typically lasts 6�24hours, insulin levels start to fall, and glucagon levels rise, promoting the breakdown of liver glycogen stores (which are exhausted after approximately 24hours) and the consequent release of glucose for energy.

Glucagon and low levels of insulin also stimulate the breakdown of triglycerides (which are mostly stored in adipose tissue) into glycerol and free fatty acids. During fasting, most tissues utilize fatty acids for energy, while the brain relies on glucose and on ketone bodies produced by hepatocytes (ketone bodies can be produced from acetyl-CoA generated from fatty acid ?-oxidation or from ketogenic amino acids). In the ketogenic phase of fasting, ketone bodies reach concentrations in the millimolar range, typically starting after 2�3 days from the beginning of the fast. Together with fat-derived glycerol and amino acids, ketone bodies fuel gluconeogenesis, which maintains glucose levels at a concentration of approximately 4mM (70mg per dl), which is mostly utilized by the brain.

Glucocorticoids and adrenaline also contribute to direct the metabolic adaptations to fasting, helping maintain blood sugar levels and stimulating lipolysis20,21. Notably, although fasting can at least temporarily increase GH levels (to increase gluconeogenesis and lipolysis and to decrease peripheral glucose uptake), fasting reduces IGF1 levels. In addition, under fasting conditions, IGF1 biological activity is restrained in part by an increase in the levels of insulin-like growth factor binding protein 1 (IGFBP1), which binds to circulating IGF1 and prevents its interaction with the corresponding cell surface receptor22.

Finally, fasting decreases the levels of circulating leptin, a hormone predominantly made by adipocytes that inhibits hunger, while increasing the levels of adiponectin, which increases fatty acid breakdown23,24. Thus, in conclusion, the hallmarks of the mammalian systemic response to fasting are low levels of glucose and insulin, high levels of glucagon and ketone bodies, low levels of IGF1 and leptin and high levels of adiponectin.

Cellular Response To Fasting

The response of healthy cells to fasting is evolutionarily conserved and confers cell protection, and at least in model organisms, has been shown to increase lifespan and healthspan12,22,25�31. The IGF1 signalling cascade is a key signalling pathway involved in mediating the effects of fasting at the cellular level. Under normal nutrition, protein consumption and increased levels of amino acids increase IGF1 levels and stimulate AKT and mTOR activity, thereby boosting protein synthesis. Vice versa, during fasting, IGF1 levels and downstream signalling decrease, reducing AKT-mediated inhibition of mammalian FOXO transcription factors and allowing these transcription factors to transactivate genes, leading to the activation of enzymes such as haem oxygenase 1 (HO1), superoxide dismutase (SOD) and catalase with antioxidant activities and protective effects32�34. High glucose levels stimulate protein kinase A (PKA) signalling, which negatively regulates the master energy sensor AMP-activated protein kinase (AMPK)35, which, in turn, prevents the expression of the stress resistance transcription factor early growth response protein 1 (EGR1) (Msn2 and/or Msn4 in yeast)26,36.

Fasting and the resulting glucose restriction inhibit PKA activity, increase AMPK activity and activate EGR1 and thereby achieve cell-protective effects, including those in the myocardium22,25,26. Lastly, fasting and FMDs (see below for their composition) also have the ability to promote regenerative effects (Box 1) by molecular mechanisms, some of which have been implicated in cancer, such as increased autophagy or induction of sirtuin activity22,37�49.

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Dietary Approaches In Cancer FMDs

The dietary approaches based on fasting that have been investigated more extensively in oncology, both preclinically and clinically, include water fasting (abstinence from all food and drinks except for water) and FMDs11,12,17,25,26,50�60 (Table 1). Preliminary clinical data indicate that a fast of at least 48hours may be required to achieve clinically meaningful effects in oncology, such as preventing chemotherapy-induced DNA damage to healthy tissues and helping to maintain patient quality of life during chemotherapy52,53,61.

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However, most patients refuse or have difficulties completing water fasting, and the potential risks of the extended calorie and micronutrient deficiency associated with it are difficult to justify. FMDs are medically designed dietary regimes very low in calories (that is, typically between 300 and 1,100kcal per day), sugars and proteins that recreate many of the effects of water-only fasting but with better patient compliance and reduced nutritional risk22,61,62. During an FMD, patients typically receive unrestricted amounts of water, small, standardized portions of vegetable broths, soups, juices, nut bars, and herbal teas, as well as supplements of micronutrients. In a clinical study of 3 monthly cycles of a 5-day FMD in generally healthy subjects, the diet was well tolerated and reduced trunk and total body fat, blood pressure and IGF1 levels62. In previous and ongoing oncological clinical trials, fasting or FMDs have typically been administered every 3�4 weeks, for example, in combination with chemotherapy regimens, and their duration has ranged between 1 and 5 days52,53,58,61,63�68. Importantly, no serious adverse events (level G3 or above, according to Common Terminology Criteria for Adverse Events) were reported in this studies52,53,58,61.

Ketogenic Diets

Ketogenic diets (KDs) are dietary regimens that have normal calorie, high-fat and low-carbohydrate content69,70. In a classical KD, the ratio between the weight of fat and the combined weight of carbohydrate and protein is 4:1. Of note, FMDs are also ketogenic because they have high-fat content and have the ability to induce substantial elevations (?0.5mmol per litre) in the levels of circulating ketone bodies. In humans, a KD can also reduce IGF1 and insulin levels (by more than 20% from baseline values), although these effects are affected by the levels and types of carbohydrates and protein in the diet71. KDs can reduce blood glucose levels, but they normally remain within the normal range (that is,>4.4mmol per litre)71.

Notably, KDs may be effective for preventing the increase in glucose and insulin that typically occurs in response to PI3K inhibitors, which was proposed to limit their efficacy72. Traditionally, KDs have been used for treating refractory epilepsy, mainly in children69. In mouse models, KDs induce anticancer effects, particularly in glioblastoma70,72�86. Clinical studies indicate that KDs probably have no substantial therapeutic activity when used as single agents in patients with cancer and suggest that potential benefits of these diets should be sought in combination with other approaches, such as chemotherapy, radiotherapy, antiangiogenic treatments, PI3K inhibitors and FMDs72,73.

KDs were reported to have neuroprotective effects in peripheral nerves and in the hippocampus87,88. However, it remains to be established whether KDs also have proregenerative effects similar to fasting or FMDs (Box 1) and whether KDs also can be used to protect living mammals from the toxicity of chemotherapy. Notably, the regenerative effects of fasting or FMDs appear to be maximized by the switch from the starvation-response mode, which involves the breakdown of cellular components and the death of many cells, and the re-feeding period, in which cells and tissues undergo reconstruction22. Because KDs do not force entry into a starvation mode, do not promote a major breakdown of intracellular components and tissues and do not include a refeeding period, they are unlikely to cause the type of coordinated regeneration observed during the FMD refeeding.

Calorie Restriction

While chronic calorie restriction (CR) and diets deficient in specific amino acids are very different from periodic fasting, they share with fasting and FMDs a more or less selective restriction in nutrients, and they have anticancer effects81,89�112. CR typically involves a chronic 20�30% reduction in energy intake from the standard calorie intake that would allow an individual to maintain a normal weight113,114. It is very effective in reducing cardiovascular risk factors and cancer incidence in model organisms, including primates108,109,114.

However, CR can cause side effects, such as changes in physical appearance, increased cold sensitivity, reduced strength, menstrual irregularities, infertility, loss of libido, osteoporosis, slower wound healing, food obsession, irritability, and depression. In patients with cancer, there are substantial concerns that it may exacerbate malnutrition and that it will unavoidably cause excessive loss of lean body mass18,113�116. CR reduces fasting blood glucose levels, though they remain within the normal range114. In humans, chronic CR does not affect IGF1 levels unless a moderate protein restriction is also implemented117.

Studies show that by reducing mTORC1 signaling in Paneth cells, CR augments their stem cell function and that it also protects reserve intestinal stem cells from DNA damage118,119, but it is unknown whether pro-regenerative effects in other organs are also elicited by CR. Thus, the available data suggest that fasting and FMDs create a metabolic, regenerative and protective profile that is distinct and probably more potent than that elicited by a KD or CR.

Fasting & FMDs In Therapy: Effects on hormone and metabolite levels

Many of the changes in the levels of circulating hormones and metabolites that are typically observed in response to fasting have the capability to exert antitumour effects (that is, reduced levels of glucose, IGF1, insulin and leptin and increased levels of adiponectin)23,120,121 and/or to afford protection of healthy tissues from side effects (that is, reduced levels of IGF1 and glucose). Because ketone bodies can inhibit histone deacetylases (HDACs), the fasting-induced increase of ketone bodies may help slow tumor growth and promote differentiation through epigenetic mechanisms122.

However, the ketone body acetoacetate has been shown to accelerate, instead of reduce, the growth of certain tumors, such as melanomas with mutated BRAF123. Those changes for which there is the strongest evidence for a role in the beneficial effects of fasting and FMDs against cancer are the reductions in the levels of IGF1 and glucose. At the molecular level, fasting or an FMD reduces intracellular signaling cascades including IGF1R�AKT�mTOR�S6K and cAMP�PKA signaling, increases autophagy, helps normal cells withstand stress and promotes anticancer immunity25,29,56,124

Differential Stress Resistance: Increasing Chemotherapy Tolerability

Some yeast oncogene orthologues, such as Ras and Sch9 (functional orthologue of mammalian S6K), are able to decrease stress resistance in model organisms27,28. In addition, mutations that activate IGF1R, RAS, PI3KCA or AKT, or that inactivate PTEN, are present in the majority of human cancers10. Together, this led to the hypothesis that starvation would cause opposite effects in cancer versus normal cells in terms of their ability to withstand cell stressors, including chemotherapeutics. In other words, starvation can lead to a differential stress resistance (DSR) between normal and cancer cells.

According to the DSR hypothesis, normal cells respond to starvation by downregulating proliferation associated and ribosome biogenesis and/or assembly genes, which forces cells to enter a self-maintenance mode and shields them from the damage caused by chemotherapy, radiotherapy and other toxic agents. By contrast, in cancer cells, this self-maintenance mode is prevented through oncogenic changes, which cause constitutive inhibition of stress response pathways12 (Fig. 1). Consistent with the DSR model, short-term starvation or the deletion of proto-oncogene homologues (that is, Sch9 or both Sch9 and Ras2) increased protection of Saccharomyces cerevisiae against oxidative stress or chemotherapy drugs by up to 100-fold as compared with yeast cells expressing the constitutively active oncogene homologue Ras2val19.

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Similar results were obtained in mammalian cells: exposure to low-glucose media protected primary mouse glia cells against toxicity from hydrogen peroxide or cyclophosphamide (a prooxidant chemotherapeutic) but did not protect mouse, rat and human glioma and neuroblastoma cancer cell lines. Consistent with these observations, a 2-day fasting effectively increased the survival of mice treated with high-dose etoposide compared with non-fasted mice and increased the survival of neuroblastoma allograftbearing mice compared with non-fasted tumor-bearing mice12.

Subsequent studies found that reduced IGF1 signaling in response to fasting protects primary glia and neurons, but not glioma and neuroblastoma cells, from cyclophosphamide and from pro-oxidative compounds and protects mouse embryonic fibroblasts from doxorubicin29. Liver IGF1-deficient (LID) mice, transgenic animals with a conditional liver Igf1 gene deletion that exhibit a 70�80% reduction in circulating IGF1 levels (levels similar to those achieved by a 72-hour fast in mice)29,125, were protected against three out of four chemotherapy drugs tested, including doxorubicin.

Histology studies showed signs of doxorubicin-induced cardiac myopathy in only doxorubicin-treated control mice but not in LID mice. In experiments with melanoma-bearing animals treated with doxorubicin, no difference in terms of disease progression between control and LID mice was observed, indicating that cancer cells were not protected from chemotherapy by reduced IGF1 levels. Yet, again, tumour-bearing LID mice exhibited a remarkable survival advantage compared with the control animals owing to their ability to withstand doxorubicin toxicity29. Thus, overall, these results confirmed that IGF1 downregulation is a key mechanism by which fasting increases chemotherapy tolerability.

Both dexamethasone and mTOR inhibitors are widely used in cancer treatment, either because of their efficacy as anti-emetics and anti-allergics (that is, corticosteroids) or for their antitumour properties (that is, corticosteroids and mTOR inhibitors). However, one of their main and frequently dose-limiting side effects is hyperglycaemia. Consistent with the notion that increased glucose�cAMP� PKA signalling reduces resistance to toxicity of chemotherapeutic drugs12,26,126, both dexamethasone and rapamycin increase toxicity of doxorubicin in mouse cardiomyocytes and mice26. Interestingly it was possible to reverse such toxicity by reducing circulating glucose levels through either fasting or insulin injections26.

These interventions reduce PKA activity while increasing AMPK activity and thereby activating EGR1, indicating that cAMP� PKA signalling mediates the fasting-induced DSR via EGR1 (ref. 26). EGR1 also promotes the expression of cardioprotective peptides, such as the atrial natriuretic peptide (ANP) and the B-type natriuretic peptide (BNP) in heart tissue, which contributes to the resistance to doxorubicin. Furthermore, fasting and/or FMD might protect mice from doxorubicin-induced cardiomyopathy by boosting autophagy, which may promote cellular health by reducing reactive oxygen species (ROS) production through the elimination of dysfunctional mitochondria and by removal of toxic aggregates.

In addition to reducing chemotherapyinduced toxicity in cells and increasing survival of chemotherapy-treated mice, cycles of fasting induce bone marrow regeneration and prevent the immunosuppression caused by cyclophosphamide in a PKA-related and IGF1-related manner25. Thus, compelling preclinical results indicate the potential of fasting and FMDs to increase chemotherapy tolerability and to avoid major side effects. Because initial clinical data lend further support to this potential, these preclinical studies build a strong rationale for evaluating FMDs in randomized clinical trials with TEAEs as a primary end point.

Differential Stress Sensitization: Increasing The Death of Cancer Cells

If used alone, most dietary interventions, including fasting and FMDs, have limited effects against cancer progression. According to the differential stress sensitization (DSS) hypothesis, the combination of fasting or FMDs with a second treatment is much more promising11,12. This hypothesis predicts that, while cancer cells are able to adapt to limited oxygen and nutrient concentrations, many types of cancer cells are not able to execute changes that would allow survival in the nutrient-deficient and toxic environment generated by the combination of fasting and chemotherapy, for example. Early experiments in breast cancer, melanoma and glioma cells found a paradoxical increase in the expression of proliferation-associated genes or of ribosome biogenesis and assembly genes in response to fasting11,12. Such changes were accompanied by unexpected AKT and S6K activation, a propensity to generate ROS and DNA damage and a sensitization to DNA-damaging drugs (via DSS)11.

We consider such an inappropriate response of cancer cells to the altered conditions including the reduction in IGF1 and glucose levels caused by fasting or FMDs as a key mechanism underlying the antitumour properties of these dietary interventions and their potential usefulness for separating the effects of anticancer treatments on normal versus malignant cells11,12 (Fig. 1). In line with the DSS hypothesis, periodic cycles of fasting or of FMDs are sufficient to slow the growth of many types of tumour cells, ranging from solid tumour cell lines to lymphoid leukaemia cells, in the mouse and, most importantly, to sensitize cancer cells to chemotherapeutics, radiotherapy and tyrosine kinase inhibitors (TKIs)11,17,22,25,50,54�57,59,60,124,127,128.

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By reducing glucose availability and increasing fatty acid ?-oxidation, fasting or FMDs can also promote a switch from aerobic glycolysis (Warburg effect) to mitochondrial oxidative phosphorylation in cancer cells, which is necessary for sustaining cancer cell growth in the most nutrient-poor environment50 (Fig. 2). This switch leads to increased ROS production11 as a result of increased mitochondrial respiratory activity and may also involve a reduction in cellular redox potential owing to decreased glutathione synthesis from glycolysis and the pentose phosphate pathway50. The combined effect of ROS augmentation and reduced antioxidant protection boosts oxidative stress in cancer cells and amplifies the activity of chemotherapeutics. Notably, because a high glycolytic activity demonstrated by high-lactate production is predictive of aggressiveness and metastatic propensity in several types of cancer129, the anti-Warburg effects of fasting or FMD have the potential to be particularly effective against aggressive and metastatic cancers.

Apart from a change in metabolism, fasting or FMDs elicit other changes that can promote DSS in pancreatic cancer cells. Fasting increases the expression levels of equilibrative nucleoside transporter 1 (ENT1), the transporter of gemcitabine across the plasma membrane, leading to improved activity of this drug128. In breast cancer cells, fasting causes SUMO2-mediated and/or SUMO3-mediated modification of REV1, a DNA polymerase and a p53-binding protein127. This modification reduces the ability of REV1 to inhibit p53, leading to increased p53-mediated transcription of pro-apoptotic genes and, ultimately, to cancer cell demise (Fig. 2). Fasting also increases the ability of commonly administered TKIs to stop cancer cell growth and/or death by strengthening MAPK signalling inhibition and, thereby, blocking E2F transcription factor-dependent gene expression but also by reducing glucose uptake17,54.

Finally, fasting can upregulate the leptin receptor and its downstream signalling through the protein PR/SET domain 1 (PRDM1) and thereby inhibit the initiation and reverse the progression of B cell and T cell acute lymphoblastic leukaemia (ALL), but not of acute myeloid leukaemia (AML)55. Interestingly, an independent study demonstrated that B cell precursors exhibit a state of chronic restriction in glucose and energy supplies imposed by the transcription factors PAX5 and IKZF1 (ref. 130). Mutations in the genes encoding these two proteins, which are present in more than 80% of the cases of pre-B cell ALL, were shown to increase glucose uptake and ATP levels. However, reconstituting PAX5 and IKZF1 in preB-ALL cells led to an energy crisis and cell demise. Taken together with the previous study, this work indicates that ALL may be sensitive to the nutrient and energy restriction imposed by fasting, possibly representing a good clinical candidate for testing the efficacy of fasting or FMD.

Notably, it is likely that many cancer cell types, including AML29, can acquire resistance by circumventing the metabolic changes imposed by fasting or FMDs, a possibility that is further increased by the metabolic heterogeneity that characterizes many cancers129. Thus, a major goal for the near future will be to identify the types of cancer that are most susceptible to these dietary regimens by means of biomarkers. On the other hand, when combined with standard therapies, fasting or FMDs have rarely resulted in the acquisition of resistance in cancer mouse models, and resistance to fasting combined with chemotherapy is also uncommon in studies in vitro, underlining the importance of identifying therapies that, when combined with FMDs, result in potent toxic effects against cancer cells with minimal toxicity to normal cells and tissues11,17,50,55�57,59,124.

Antitumour Immunity Enhancement by Fasting or FMD

Recent data suggest that fasting or FMDs by themselves, and to a greater extent when combined with chemotherapy, trigger the expansion of lymphoid progenitors and promote tumour immune attack via different mechanisms25,56,60,124. An FMD reduced the expression of HO1, a protein that confers protection against oxidative damage and apoptosis, in cancer cells in vivo but upregulated HO1 expression in normal cells124,131. HO1 downregulation in cancer cells mediates FMD-induced chemosensitization by increasing CD8+ tumour-infiltrating lymphocyte-dependent cytotoxicity, which may be facilitated by the downregulation of regulatory T cells124 (Fig. 2). Another study, which confirmed the ability of fasting or FMDs and CR mimetics to improve anticancer immunosurveillance, implies that the anticancer effects of fasting or FMDs may apply to autophagy competent, but not autophagy-deficient, cancers56. Finally, a recent study of alternate-day fasting for 2 weeks in a mouse colon cancer model showed that, by activating autophagy in cancer cells, fasting downregulates CD73 expression and consequently decreases the production of immunosuppressive adenosine by cancer cells60. Ultimately, CD73 downregulation via fasting was shown to prevent macrophage shift to an M2 immunosuppressive phenotype (Fig. 2). On the basis of these studies, it is appealing to speculate that FMDs could be particularly useful instead of or in combination with immune checkpoint inhibitors132, cancer vaccines or other drugs that prompt antitumour immunity, including some conventional chemotherapeutics133.

Anticancer Diets in Mouse Models

Overall, the results of preclinical studies of fasting or FMDs in animal cancer models, including models for metastatic cancer (Table 2), show that periodic fasting or FMDs achieve pleiotropic anticancer effects and potentiate the activity of chemotherapeutics and TKIs while exerting protective and regenerative effects in multiple organs22,25. Achieving the same effects without fasting and/or FMDs would require first the identification and then the use of multiple effective, expensive and frequently toxic drugs and would probably be without the advantage of inducing healthy cell protection. It is noteworthy that in at least two studies fasting combined with chemotherapy proved to be the only intervention capable of achieving either complete tumour regressions or long-term survival in a consistent fraction of the treated animals11,59

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Chronic KDs also show a tumour growth-delaying effect when used as a monotherapy, particularly in brain cancer mouse models77,78,80�82,84,134. Gliomas in mice maintained on a chronic KD have reduced expression of the hypoxia marker carbonic anhydrase 9 and of hypoxia-inducible factor 1?, decreased nuclear factor-?B activation and reduced vascular marker expression (that is, vascular endothelial growth factor receptor 2, matrix metalloproteinase 2 and vimentin)86. In an intracranial mouse model of glioma, mice fed a KD exhibited increased tumour-reactive innate and adaptive immune responses that were primarily mediated by CD8+ T cells79. KDs were shown to improve the activity of carboplatin, cyclophosphamide and radiotherapy in glioma, lung cancer and neuroblastoma mouse models73�75,135. In addition, a recent study shows that a KD could be very useful in combination with PI3K inhibitors72. By blocking insulin signalling, these agents promote glycogen breakdown in the liver and prevent glucose uptake in the skeletal muscle, which leads to transient hyperglycaemia and to a compensatory insulin release from the pancreas (a phenomenon known as �insulin feedback�). In turn, this raise in insulin levels, which can be protracted, particularly in patients with insulin resistance, reactivates PI3K�mTOR signalling in tumours, thus strongly limiting the benefit of PI3K inhibitors. A KD was shown to be very effective at preventing insulin feedback in response to these drugs and to strongly improve their anticancer activity in the mouse. Finally, according to a study in a murine tumour-induced cachexia model (MAC16 tumours), KDs could help prevent the loss of fat and non-fat body mass in patients with cancer85.

CR reduced tumorigenesis in genetic mouse cancer models, mouse models with spontaneous tumorigenesis and carcinogen induced cancer mouse models, as well as in monkeys91,92,97,98,101,102,104�106,108,109,136�138. By contrast, a study found that CR from middle age actually increases the incidence of plasma cell neoplasms in C57Bl/6 mice139. However, in the same study, CR also extended maximum lifespan by approximately 15%, and the observed increase in cancer incidence was attributed to the increased longevity of mice undergoing CR, the age at which tumour-bearing mice undergoing CR died and the percentage of tumour-bearing mice undergoing CR that died. Thus, the authors concluded that CR probably retards promotion and/or progression of existing lymphoid cancers. A meta-analysis comparing chronic CR with intermittent CR in terms of their ability to prevent cancer in rodents concluded that intermittent CR is more effective in genetically engineered mouse models, but it is less effective in chemically induced rat models90. CR was shown to slow tumour growth and/or to extend mouse survival in various cancer mouse models, including ovarian and pancreatic cancer140,94 and neuroblastoma81.

Importantly, CR improved the activity of anticancer treatment in several cancer models, including the activity of an antiIGF1R antibody (ganitumab) against prostate cancer141, cyclophosphamide against neuroblastoma cells135 and autophagy inhibition in xenografts of HRAS-G12Vtransformed immortal baby mouse kidney epithelial cells100. However, CR or a KD in combination with anticancer therapies seems to be less effective than fasting. A mouse study found that, in contrast to fasting alone, CR alone was not able to reduce the growth of subcutaneously growing GL26 mouse gliomas and that, again, in contrast to short-term fasting, CR did not increase cisplatin activity against subcutaneous 4T1 breast tumours51. In the same study, fasting also proved substantially more effective than CR and a KD at increasing the tolerability of doxorubicin51. Although fasting or an FMD, CR and a KD likely act on and modulate overlapping signalling pathways, fasting or an FMD probably affects such mechanisms in a more drastic fashion during an intense acute phase of a maximum duration of a few days.

The phase of refeeding could then favour the recovery of homeostasis of the whole organism but also activate and invigorate mechanisms that can promote the recognition and removal of the tumour and regenerate the healthy cells. CR and a KD are chronic interventions that are able to only moderately repress nutrient-sensing pathway, possibly without reaching certain thresholds necessary to improve the effects of anticancer drugs, while imposing a major burden and often a progressive weight loss. CR and a KD as chronic dietary regimens in patients with cancer are difficult to implement and likely bear health risks. CR would likely lead to severe loss of lean body mass and the reduction of steroid hormones and possibly immune function142. Chronic KDs are also associated with similar although less severe side effects143. Thus, periodic fasting and FMD cycles lasting less than 5 days applied together with standard therapies have a high potential to improve cancer treatment while reducing its side effects. Notably, it will be important to study the effect of the combination of periodic FMDs, chronic KDs and standard therapies, particularly for the treatment of aggressive cancers such as glioma.

Fasting and FMDs in Cancer Prevention

Epidemiological studies and studies in animals, including monkeys108,109,144, and humans lend support to the notion that chronic CR and periodic fasting and/or an FMD could have cancer-preventive effects in humans. Nevertheless, CR can hardly be implemented in the general population owing to issues of compliance and to possible side effects115. Thus, while evidence-based recommendations of foods to prefer (or to avoid) as well as lifestyle recommendations to reduce cancer risk are becoming established6,8,9,15, the goal now is to identify and, possibly, standardize well tolerated, periodic dietary regimens with low or no side effects and evaluate their cancer-preventive efficacy in clinical studies.

As discussed earlier, FMD cycles cause downregulation of IGF1 and glucose and upregulation of IGFBP1 and ketone bodies, which are changes similar to those caused by fasting itself and are biomarkers of the fasting response22. When C57Bl/6 mice (which spontaneously develop tumours, primarily lymphomas, as they age) were fed such an FMD for 4 days twice a month starting at middle age and an ad libitum diet in the period between FMD cycles, the incidence of neoplasms was reduced from approximately 70% in mice on the control diet to approximately 40% in mice in the FMD group (an overall 43% reduction)22. In addition, the FMD postponed by over 3 months the occurrence of neoplasm related deaths, and the number of animals with multiple abnormal lesions was more than threefold higher in the control group than in the FMD mice, indicating that many tumours in the FMD mice were less aggressive or benign.

A previous study of alternate-day fasting, which was performed in middle-aged mice for a total of 4 months, also found that fasting reduced the incidence of lymphoma, bringing it from 33% (for control mice) to 0% (in fasted animals)145, although because of the short duration of the study it is unknown whether this fasting regimen prevented or simply delayed the tumour onset. Furthermore, alternate-day fasting imposes 15 days per month of complete water-only fasting, whereas in the FMD experiment described above mice were placed on a diet that provided a limited amount of food for only 8 days per month. In humans, 3 cycles of a 5-day FMD once a month were shown to reduce abdominal obesity and markers of inflammation as well as IGF1 and glucose levels in subjects with elevated levels of these markers62, indicating that periodic use of an FMD could potentially have preventive effects for obesity-related or inflammation-related, but also other, cancers in humans, as it has been shown for mice22.

Therefore, the promising results of preclinical studies combined with the clinical data on the effect of an FMD on risk factors for ageing-associated diseases, including cancer62, lend support to future randomized studies of FMDs as a possibly effective tool to prevent cancer, as well as other ageing-associated chronic conditions, in humans.

Clinical Applicability in Oncology

Four feasibility studies of fasting and FMDs in patients undergoing chemotherapy have been published as of today52,53,58,61. In a case series of 10 patients diagnosed with various types of cancer, including breast, prostate, ovarian, uterus, lung and oesophageal cancer, who voluntarily fasted for up to 140hours before and/or up to 56hours following chemotherapy, no major side effects caused by fasting itself other than hunger and lightheadedness were reported58. Those patients (six) who underwent chemotherapy with and without fasting reported a significant reduction in fatigue, weakness and gastrointestinal adverse events while fasting. In addition, in those patients in which cancer progression could be assessed, fasting did not prevent chemotherapy-induced reductions in tumour volume or in tumour markers. In another study, 13 women with HER2 (also known as ERBB2) negative, stage II/III breast cancer receiving neo-adjuvant taxotere, adriamycin and cyclophosphamide (TAC) chemotherapy were randomized to fast (water only) 24hours before and after beginning chemotherapy or to nutrition according to standard guidelines52.

Short-term fasting was well tolerated and reduced the drop in mean erythrocyte and thrombocyte counts 7 days after chemotherapy. Interestingly, in this study, the levels of ?-H2AX (a marker of DNA damage) were increased 30minutes after chemotherapy in leukocytes from non-fasted patients but not in patients who had fasted. In a dose escalation of fasting in patients undergoing platinum-based chemotherapy, 20 patients (who were primarily treated for either urothelial, ovarian or breast cancer) were randomized to fast for 24, 48 or 72hours (divided as 48hours before chemotherapy and 24hours after chemotherapy)53. Feasibility criteria (defined as three or more out of six subjects in each cohort consuming?200kcal per day during the fast period without excess toxicity) were met. Fasting-related toxicities were always grade 2 or below, the most common being fatigue, headache and dizziness. As in the previous study, reduced DNA damage (as detected by comet assay) in leukocytes from subjects who fasted for at least 48hours (as compared with subjects who fasted for only 24hours) could also be detected in this small trial. In addition, a nonsignificant trend towards less grade 3 or grade 4 neutropenia in patients who fasted for 48 and 72hours versus those who fasted for only 24hours was also documented.

Very recently, a randomized crossover clinical trial was conducted assessing the effects of an FMD on quality of life and side effects of chemotherapy in a total of 34 patients with breast or ovarian cancer61. The FMD consisted of a daily caloric intake of<400kcal, primarily by juices and broths, starting 36�48hours before the beginning of chemotherapy and lasting until 24hours after the end of chemotherapy. In this study, the FMD prevented the chemotherapy induced reduction in quality of life and it also reduced fatigue. Again, no serious adverse events of the FMD were reported. Several other clinical trials of FMDs in combination with chemotherapy or with other types of active treatments are currently ongoing at US and European hospitals, primarily in patients who are diagnosed with breast or prostate cancer63,65�68. These are either one-arm clinical studies to assess FMD safety and feasibility or randomized clinical studies focusing either on the effect of the FMD on the toxicity of chemotherapy or on the quality of life of patients during chemotherapy itself. Altogether, these studies have now enrolled over 300 patients, and their first results are expected to become available in 2019.

cancer and fasting el paso tx.

Challenges in The Clinic

The study of periodic fasting or of FMDs in oncology is not devoid of concerns, particularly in relation to the possibility that this type of dietary regimen could precipitate malnutrition, sarcopenia, and cachexia in predisposed or frail patients (for example, patients who develop anorexia as a consequence of chemotherapy)18,19. However, no instances of severe (above grade 3) weight loss or of malnutrition were reported in the clinical studies of fasting in combination with chemotherapy published as of now, and those patients who did experience a weight loss during fasting typically recovered their weight before the subsequent cycle without detectable harm. Nevertheless, we recommend that periodic anorexia and nutritional status assessments using gold-standard approaches18,19,146�150 should be an integral part of these studies and that any ensuing nutritional impairment in patients undergoing fasting and/or FMDs is rapidly corrected.

Conclusions

Periodic fasting or FMDs consistently show powerful anticancer effects in mouse cancer models including the ability to potentiate chemoradiotherapy and TKIs and to trigger anticancer immunity. FMD cycles are more feasible than chronic dietary regimens because they allow patients to consume food regularly during the FMD, maintain a normal diet between cycles and do not result in severe weight loss and possibly detrimental effects on the immune and endocrine systems. Notably, as standalone therapies, periodic fasting or FMD cycles would probably show limited efficacy against established tumors. In fact, in mice, fasting or FMDs affect the progression of a number of cancers similarly to chemotherapy, but alone, they rarely match the effect obtained in combination with cancer drugs which can result in cancer-free survival11,59. Thus, we propose that it is the combination of periodic FMD cycles with standard treatments that holds the highest potential to promote cancer-free survival in patients, as suggested by the mouse models11,59 (Fig. 3).

This combination may be particularly potent for several reasons: first, cancer drugs and other therapies can be effective, but a portion of patients do not respond because cancer cells adopt alternative metabolic strategies leading to survival. These alternative metabolic modes are much more difficult to sustain under fasting or FMD conditions because of the deficiencies or changes in glucose, certain amino acids, hormones, and growth factors, as well as in other unknown pathways leading to cell death. Second, fasting or FMDs can prevent or reduce resistance acquisition. Third, fasting or FMDs protect normal cells and organs from the side effects caused by a wide variety of cancer drugs. On the basis of preclinical and clinical evidence of feasibility, safety and efficacy (at reducing IGF1, visceral fat and cardiovascular risk factors), FMDs also appear as a viable dietary approach to be studied in cancer prevention. An important future challenge will be to identify those tumours that are the best candidates to benefit from fasting or FMDs. Even in cancer types that are apparently less responsive to fasting or FMDs, it may still be possible to identify the mechanisms of resistance and to intervene with drugs able to revert that resistance. Conversely, more caution should be adopted with other types of diets, especially if high in calories, as they could lead to exacerbated and not inhibited growth of certain cancers. For example, the KD increases growth of a melanoma model with mutated BRAF in mice123, and it was also reported to accelerate disease progression in a mouse AML model72.

Furthermore, it is essential to apply FMDs with an understanding of the mechanisms of action, since their potency if applied incorrectly could generate negative effects. For example, when rats were fasted and treated with a potent carcinogen before refeeding, this resulted in the growth of aberrant foci in liver, colon and rectum when compared with non-fasted rats151,152. Although the mechanisms involved in this effect are not understood, and these foci may have not resulted in tumours, these studies suggest that a minimum period of 24�48hours between the chemotherapy treatment and the return to the normal diet is important to avoid combining the regrowth signals present during the refeeding after fasting with high levels of toxic drugs such as chemotherapy. The clinical studies of fasting or FMD in patients undergoing chemotherapy support its feasibility and overall safety52,53,58,61. In a small-size randomized trial that enrolled 34 patients, an FMD helped patients maintain their quality of life during chemotherapy and reduced fatigue61. In addition, preliminary data suggest the potential of fasting or FMDs to reduce chemotherapy induced DNA damage in healthy cells in patients52,53.

Ongoing clinical studies of FMDs in patients with cancer63,65�68 will provide more solid answers as to whether prescribing periodic FMDs in combination with conventional anticancer agents helps improve tolerability and activity of the latter. It is important to consider that FMDs will not be effective in reducing the side effects of cancer treatments in all patients and neither will they work to improve the efficacy of all therapies, but they have great potential to do so at least for a portion and possibly for a major portion of patients and drugs. Frail or malnourished patients or patients at risk of malnutrition should not be enrolled in clinical studies of fasting or FMDs, and patient nutritional status and anorexia should be carefully monitored throughout clinical trials. An appropriate intake of proteins, essential fatty acids, vitamins and minerals combined, where possible, with light and/or moderate physical activity aimed at increasing muscle mass should be applied between fasting or FMD cycles in order for the patients to maintain a healthy lean body mass18,19. This multimodal dietary approach will maximize the benefits of fasting or FMDs while at the same time protecting patients from malnutrition.

References:

Five Days With ProLon� And You Will See Results | El Paso, TX.

Five Days With ProLon� And You Will See Results | El Paso, TX.

Recent science has unleashed the power of fasting to optimize body aging and dismantle chronic diseases, e.g., obesity, diabetes, cancer, autoimmune disorders, Alzheimer�s and cardiovascular disease. At El Paso Back Clinic, Dr. Jimenez’s mission is to educate the public about the health benefits of fasting. The idea is to introduce it to them in a safe, effective way through the Fasting Mimicking Diet (FMD).

Pre-clinical and clinical studies have proven that periodic fasting, done for several consecutive days, is a very powerful intervention that our bodies learned to naturally cope with by protecting and rejuvenating itself. These two factors are both anti-aging measures that offer additional health benefits. The 5-Day ProLon Fasting Mimicking Diet has been clinically tested and found to promote beneficial effects in a wide variety of conditions ranging from excess weight and fasting blood glucose, to growth factors associated with DNA damage and aging.

Min Wei; Sebastian Brandhorst et al.
Fasting?Mimicking Diet and Risk Factors for Aging, Diabetes, Cancer and Cardiovascular Disease.

5-Day Program

The ProLon meal plan is followed 5 days per month. Once an individual has finished the five-day plan, they go back to a normal healthy diet the last twenty-five days. Fasting with the Prolon� plan follows a low carbohydrate/protein meal and contains the good kind of fatty acids. The FMD� recipe keeps your body on a fasting-type mode, that triggers protection measures that the body has developed. This causes the body to optimize its performance, rejuvenate cells, and thrive.

Unboxing the ProLon Fasting Mimicking Diet

just five days with prolon� el paso, tx.

Age-related Disease: A Revolution Is Coming

I just finished reading a groundbreaking book called The Longevity Diet: Discover the New Science Behind Stem Cell Activation and Regeneration to Slow Aging, Fight Disease, and Optimize Weight, which was written by Valter Longo, PhD,1 who is director of the Longevity Institute at the University of Southern California and a principal scientist in the development and study of the fasting mimicking diet (FMD). I have followed Dr. Longo�s career for many years with great admiration. He has been published in top-tier journals. In his book, Dr. Longo writes about some exciting findings regarding the FMD research group consisting of 16-month-old mice, which are described as being the equivalent of a 45-year-old human: �A stem cell-dependent process rejuvenated the immune system. Regeneration also occurred in the liver, muscle, and brain. Levels of several types of stem cells increased.�1 He went on to explain: �The fasting itself destroys many damaged cells and damaged components inside the cells but it also activates stem cells.�1


Jeffrey S. Bland, PhD, FACN, FACB, Associate Editor
just five days with prolon� el paso, tx.

Get Your Free Copy At El Paso Back Clinic!

Fasting-Mimicking Diet Promotes b-Cell Regeneration to Reverse Diabetes

  • Fasting mimicking diet induces prenatal-development gene expression in adult pancreas
  • FMD promotes Ngn3 expression to generate insulin-producing b cells
  • Cycles of FMD reverse b-cell failure and rescue mice fromT1D and T2Dd
  • Inhibition of PKA or mTOR promotes Ngn3-driven b-cell regeneration in human T1D islets
just five days with prolon� el paso, tx.

Stem-cell-based therapies can potentially reverse organ dysfunction and diseases, but the removal of impaired tissue and activation of a program leading to organ regeneration pose major challenges. In mice, 4-day fasting mimicking diet (FMD) induces a stepwise expression of Sox17 and Pdx-1, followed by Ngn3-driven generation of insulin-producing b cells, resembling that observed during pancreatic development. FMD cycles restore insulin secretion and glucose homeostasis in both type 2 and type 1diabetes mouse models.

In human type 1 diabetes pancreatic islets, fasting conditions reduce PKAand mTOR activity and induce Sox2 and Ngn3expression and insulin production. The effects of the FMD are reversed by IGF-1 treatment and recapitulated by PKA and mTOR inhibition. These results indicate that an FMD promotes the reprogramming of pancreatic cells to restore insulin generation in islets from T1D patients and reverse both T1D andT2D phenotypes in mouse models.

Chia-Wei Cheng,1,6,7Valentina Villani,2,7Roberta Buono,1,5,7Min Wei,1Sanjeev Kumar,4Omer H. Yilmaz,6Pinchas Cohen,1Julie B. Sneddon,3Laura Perin,2and Valter D. Longo1,4,5,8,*
just five days with prolon� el paso, tx.
Stop Eating This and Stop the Chronic Pain

Stop Eating This and Stop the Chronic Pain

Do you sometimes feel like your chronic pain becomes worse after eating certain foods? As a matter of fact, research studies have demonstrated that eating several types of foods can trigger an inflammatory response in the human body. And we all know that inflammation can be one of the primary causes for your chronic pain flare-ups. Before we discuss the foods that can cause inflammation and the foods that can fight against inflammation, let’s discuss what is inflammation and how you can measure inflammation.

What is Inflammation?

Inflammation is the immune system’s natural defense mechanism. It functions by protecting the human body from injury, illness, and infection. Inflammation helps to maintain overall health and wellness. Allergic reactions can also result in inflammation. When you’re injured or you have an infection, you can see symptoms of inflammation: or swollen, red, and hot spots. However, inflammation may occur seemingly without a cause. The ideal way to diagnose inflammation is to measure specific biomarkers through blood tests.

The C-reactive protein, or CRP, a substance produced by the liver, is one of the best biomarkers of inflammation. CRP levels increase as inflammation increases, therefore, you can know a lot about what’s happening inside your own body by looking at your CRP levels. According to the American Heart Association and the Centers for Disease Control and Prevention, a CRP concentration of under 1.0 mg/L suggests a low risk for heart issues; between 1.0 to 3.0 mg/L suggests an average risk for heart issues; and over 3.0 mg/L suggests a high risk for heart issues. Substantial levels of CRP (greater than 10 mg/L) may also suggest a risk of developing other health issues.

Other biomarkers like activated monocytes, cytokines, chemokines, various adhesion molecules, adiponectin, fibrinogen, and serum amyloid alpha, are other biomarkers which can be measured through blood tests to diagnose inflammation. Inflammatory responses consist of sympathetic activity, oxidative stress, nuclear factor kappaB (NF-kB) activation, and proinflammatory cytokine production.

White blood cells play an important part in the human body’s immune system. Every time a bacteria or virus enters the bloodstream, the white blood cells, or leukocytes, recognize and destroy the foreign invaders. You might believe that an increased white blood cell count may be beneficial since white blood cells fight infection, however, this may not necessarily be the case. An increased white blood cell count may indicate the presence of another health issue, although a large white blood cell count is not a problem itself.

Foods that Cause Inflammation

Not surprisingly, the same types of foods which can cause inflammation are also generally considered to be bad for our health, such as refined carbohydrates, and sodas as well as red meat, and processed meats. Inflammation is an important underlying mechanism which has been associated with an increased risk for chronic diseases like type 2 diabetes and heart disease, among other health issues.

Unhealthy foods also contribute to weight gain, which is itself a risk factor for inflammation. In several research studies, even after researchers took obesity into account, the connection between inflammation and these foods remained, which suggests that weight gain is not a cause of inflammation. Some foods have an increased effect on inflammation and increased caloric consumption.

Foods that can cause inflammation include:

  • Refined carbohydrates, such as white bread and pastries
  • French fries and other fried foods
  • Sodas and other sugar-sweetened drinks
  • Red meat like burgers and steaks as well as processed meat like hot dogs and sausage
  • Margarine, shortening, and lard

Foods that Fight Against Inflammation

Alternatively, there are foods that fight against inflammation, and with it, chronic disease. Certain fruits and vegetables, such as blueberries, apples, and leafy greens, are high in polyphenols and antioxidants, which are components that may have anti-inflammatory effects. Research studies also have associated nuts with reduced biomarkers of inflammation and a decreased risk of diabetes and cardiovascular disease. Coffee may protect against inflammation, as well. Choose anti-inflammatory foods and you could improve your overall health and wellness. Choose inflammatory foods and you might increase the risk of inflammation and chronic pain.

Foods that can fight against inflammation include:

  • Tomatoes
  • Olive oil
  • Green leafy vegetables, such as spinach, kale, and collards
  • Nuts like almonds and walnuts
  • Fatty fish, such as salmon, tuna, mackerel, and sardines
  • Fruits like strawberries, blueberries, cherries, and oranges
Dr Jimenez White Coat

Healthcare professionals are learning that one of the greatest ways to reduce inflammation is found. not in the medicine cabinet, but in the refrigerator. An anti-inflammatory diet can ultimately help reduce the human body’s inflammatory response. The immune system triggers inflammation to protect the human body from injury, illness, and infection. But if inflammation continues, it can cause a variety of health issues, including chronic pain symptoms. Research studies have demonstrated that certain food can influence the effects of inflammation in the human body.

Dr. Alex Jimenez D.C., C.C.S.T. Insight

Anti-Inflammatory Diets

To reduce inflammation, focus on following an overall healthier diet. If you’re looking for an anti-inflammatory diet, consider following the Mediterranean diet, which is high in fruits, vegetables, nuts, whole grains, fish, and oils. The Longevity Diet Plan, presented in the book by Dr. Valter Longo, also eliminates foods which can cause inflammation, promoting well-being and longevity. Fasting, or caloric restriction, has long been known to decrease oxidative stress and slow down the mechanisms of aging in various organisms.

the-longevity-diet-book-new.png

And if fasting is not for you, Dr. Valter Longo’s longevity diet plan also includes the fasting mimicking diet, or FMD, which allows you to experience the benefits of traditional fasting without depriving your body of food. The main difference of the FMD is that instead of eliminating all food for several days or even weeks, you only restrict your calorie intake for five days out of the month. The FMD can be practiced once a month to help promote overall health and wellness as well as to help reduce inflammation and chronic pain.

While anyone can follow the FMD on their own, Dr. Valter Longo offers the ProLon� fasting mimicking diet, a 5-day meal program which has been individually packed and labeled to serves the foods you need for the FMD in precise quantities and combinations. The meal program consists of ready-to-eat and easy-to-prepare, plant-based foods, including bars, soups, snacks, supplements, a drink concentrate, and teas. However, before starting the ProLon� fasting mimicking diet, 5-day meal program, or any of the lifestyle modifications described above, please make sure to talk to a doctor to find out which chronic pain treatment is right for you.

ProLon Fasting Mimicking Diet Banner

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In addition to reducing inflammation, a more natural, less processed diet can have noticeable effects on your physical and emotional health. The scope of our information is limited to chiropractic, spinal health issues, and functional medicine articles, topics, and discussions. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .

Curated by Dr. Alex Jimenez

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Additional Topic Discussion: Acute Back Pain

Back pain is one of the most prevalent causes of disability and missed days at work worldwide. Back pain attributes to the second most common reason for doctor office visits, outnumbered only by upper-respiratory infections. Approximately 80 percent of the population will experience back pain at least once throughout their life. Your spine is a complex structure made up of bones, joints, ligaments, and muscles, among other soft tissues. Injuries and/or aggravated conditions, such as herniated discs, can eventually lead to symptoms of back pain. Sports injuries or automobile accident injuries are often the most frequent cause of back pain, however, sometimes the simplest of movements can have painful results. Fortunately, alternative treatment options, such as chiropractic care, can help ease back pain through the use of spinal adjustments and manual manipulations, ultimately improving pain relief.

Xymogen Formulas - El Paso, TX

XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.

Proudly, Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.

Please call our office in order for us to assign a doctor consultation for immediate access.

If you are a patient of Injury Medical & Chiropractic Clinic, you may inquire about XYMOGEN by calling 915-850-0900.

xymogen el paso, tx

For your convenience and review of the XYMOGEN products please review the following link.*XYMOGEN-Catalog-Download

* All the above XYMOGEN policies remain strictly in force.

***

Fasting and Chronic Pain

Fasting and Chronic Pain

Chronic pain is a common health issue which affects many people in the United States. While several medical conditions, such as fibromyalgia and myofascial pain syndrome, can cause chronic pain, it may also develop due to a variety of other health issues. Research studies have found that widespread inflammation is the leading cause of chronic pain. Inflammation is a natural defense mechanism to injury, illness, or infection. But, if the inflammatory process continues for too long, it can become problematic.

Inflammation signals the immune system to heal and repair damaged tissue as well as to protect itself against bacteria and viruses. As mentioned above, however, chronic inflammation can cause a variety of health issues, including chronic pain symptoms. Healthy lifestyle modifications can help manage chronic pain, but first, let’s understand the common causes of chronic pain.

What is Acute Inflammation?

Acute inflammation, by way of instance, occurs following an injury or something as simple as a sore throat. It is a natural response with adverse effects, meaning it works locally in the region where the health issue is found. The common signs of acute inflammation include swelling, redness, warmth, pain and loss of function, as stated by the National Library of Medicine. When acute inflammation develops, the blood vessels dilate causing blood flow to increase, and white blood cells in the injured region promote recovery.

During severe inflammation, compounds called cytokines are released by the damaged tissue. The cytokines act as “emergency signals” which bring on the human body’s own immune cells, as well as hormones and numerous nutrients to repair the health issue. Additionally, hormone-like substances, known as prostaglandins, cause blood clots to heal damaged tissue, and these may also trigger fever and pain as part of the inflammatory procedure. As the damage or injury recovers, the inflammation subsides.

What is Chronic Inflammation?

Unlike acute inflammation, chronic inflammation has long-term effects. Chronic inflammation, also known as persistent inflammation, produces low-levels of inflammation throughout the human body, as demonstrated by an increase in immune system markers located in blood and cell tissues. Chronic inflammation may also cause the progression of various diseases and conditions. Elevated levels of inflammation may sometimes trigger even if there is no injury, illness, or infection, which may also cause the immune system to react.

As a result, the human body’s immune system could begin attacking healthy cells, tissues, or organs. Researchers are still trying to understand the consequences of chronic inflammation in the human body and the mechanisms involved in this natural defense process. By way of instance, chronic inflammation has been associated with a variety of health issues, such as heart disease, and stroke.

One theory suggests that when inflammation remains in the blood vessels, it can encourage the accumulation of plaque. According to the American Heart Association, or the AHA, if the immune system identifies plaque as a foreign invader, the white blood cells can attempt to wall off the plaque found in the blood flowing through the arteries. This can create a blood clot which may block the blood flow to the heart or brain, causing it to become unstable and rupture. Cancer is another health issue associated with chronic inflammation. Furthermore, according to the National Cancer Institute, DNA damage can also be caused by chronic inflammation.

Persistent, low-grade inflammation frequently doesn’t have any symptoms, but healthcare professionals can check for a C-reactive protein, or CRP, known as lipoic acid, a marker for inflammation found in the blood. Elevated levels of CRP are associated with an increased risk of cardiovascular disease. Elevated CRP levels may be found in chronic disorders like lupus or rheumatoid arthritis.

In the case of other chronic conditions, such as fibromyalgia, the nervous system over-reacts to specific stimulation, however, it’s inflammation which causes chronic pain symptoms. Subjectively, it’s almost impossible to tell the difference between the chronic pain caused by an oversensitive nervous system and the chronic pain caused by widespread inflammation. Apart from searching for clues in the bloodstream, a person’s nutrition, lifestyle habits, and environmental exposures, can also promote chronic inflammation.

Dr Jimenez White Coat

Inflammation is the immune system’s natural defense mechanism against injury, illness, or infection. While this inflammatory response can help heal and repair tissues, chronic, widespread inflammation can cause a variety of health issues, including chronic pain symptoms. A balanced nutrition, including a variety of diets and fasting, can help reduce inflammation. Fasting, also known as caloric restriction, promotes cell apoptosis and mitochondrial recovery. The fasting mimicking diet, which is a part of the longevity diet plan, is a dietary program which “tricks” the human body into a fasting state to experience the benefits of traditional fasting. Before following any of the diets described in this article, make sure to consult a doctor.

Dr. Alex Jimenez D.C., C.C.S.T. Insight

ProLon Fasting Mimicking Diet Banner

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Nutrition, Diets, Fasting and Chronic Pain

Anti-inflammatory diets mainly consist of eating fresh fruits and vegetables, fish, and fats. The Mediterranean diet plan, by way of instance, is an anti-inflammatory diet which promotes eating moderate amounts of nuts, ingesting very little meat, and drinking wine. Anti-inflammatory food parts, such as omega-3 fatty acids, protect the human body against the damage brought on by inflammation.

An anti-inflammatory diet also involves staying away from foods which could promote inflammation. It is ideal to decrease the amount of foods you eat which are high in trans and saturated fats, such as meats. Additionally, an anti-inflammatory diet limits the consumption of refined carbohydrates and foods, such as bread and rice. These also promote cutting back on the utilization of margarine and oils that are packed with omega-6 fatty acids, such as sunflower, safflower and corn oils.

Fasting, or caloric restriction, has long been known to decrease oxidative stress and slow down the mechanisms of aging in various organisms. The effects of fasting involve programmed cell death, or apoptosis, transcription, mobile energy efficiency, mitochondrial biogenesis, antioxidant mechanisms, and circadian rhythm. Fasting also contributes to mitochondrial autophagy, known as mitophagy, where genes in the mitochondria are stimulated to undergo apoptosis, which promotes mitochondrial recovery.

Intermittent fasting can help you fight inflammation, improve digestion, and boost your longevity. The human body is designed to be able to survive for extended periods of time without food. Research studies have demonstrated that intermittent fasting can have positive changes in the overall composition of your gut microbiota. Moreover, intermittent fasting can reduce insulin resistance while increasing the immune system response. Finally, intermittent fasting can promote the production of a substance, known as ?-hydroxybutyrate, that blocks a portion of the immune system involved in inflammatory ailments as well as substantially reducing the production of inflammatory markers, such as cytokines and the C-reactive protein, or CRP, previously mentioned above.

The Longevity Diet Plan, presented in the book by Dr. Valter Longo, eliminates the consumption of processed foods which can cause inflammation, promoting well-being and longevity. This unique dietary program, unlike most traditional diets, doesn’t promote weight loss. Although you may experience weight reduction, the emphasis of this unique dietary program is on eating healthier. The Longevity Diet Plan has been demonstrated to help activate stem cell-based renewal, reduce abdominal fat, and prevent age-related bone and muscle loss, as well as build resistance to developing cardiovascular disease, Alzheimer’s disease, diabetes, and cancer.

the-longevity-diet-book-new.png

The fasting mimicking diet, or FMD, allows you to experience the benefits of traditional fasting without depriving your body of food. The main difference of the FMD is that instead of completely eliminating all food for several days or even weeks, you only restrict your calorie intake for five days out of the month. The FMD can be practiced once a month to help promote overall health and wellness.

While anyone can follow the FMD on their own, the ProLon� fasting mimicking diet offers a 5-day meal program which has been individually packed and labeled for each day, that serves the foods you need for the FMD in precise quantities and combinations. The meal program is made up of ready-to-eat or easy-to-prepare, plant-based foods, including bars, soups, snacks, supplements, a drink concentrate, and teas. Before starting the ProLon� fasting mimicking diet, 5-day meal program, or any of the lifestyle modifications described above, please make sure to talk to a healthcare professional to find out which chronic pain treatment is right for you.

The scope of our information is limited to chiropractic, spinal health issues, and functional medicine articles, topics, and discussions. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .

Curated by Dr. Alex Jimenez

Green Call Now Button H .png

Additional Topic Discussion: Acute Back Pain

Back pain is one of the most prevalent causes of disability and missed days at work worldwide. Back pain attributes to the second most common reason for doctor office visits, outnumbered only by upper-respiratory infections. Approximately 80 percent of the population will experience back pain at least once throughout their life. Your spine is a complex structure made up of bones, joints, ligaments, and muscles, among other soft tissues. Injuries and/or aggravated conditions, such as herniated discs, can eventually lead to symptoms of back pain. Sports injuries or automobile accident injuries are often the most frequent cause of back pain, however, sometimes the simplest of movements can have painful results. Fortunately, alternative treatment options, such as chiropractic care, can help ease back pain through the use of spinal adjustments and manual manipulations, ultimately improving pain relief.

Xymogen Formulas - El Paso, TX

XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.

Proudly, Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.

Please call our office in order for us to assign a doctor consultation for immediate access.

If you are a patient of Injury Medical & Chiropractic Clinic, you may inquire about XYMOGEN by calling 915-850-0900.

xymogen el paso, tx

For your convenience and review of the XYMOGEN products please review the following link.*XYMOGEN-Catalog-Download

* All the above XYMOGEN policies remain strictly in force.

***

Rejuvenate With ProLon’s� FMD

Rejuvenate With ProLon’s� FMD

Rejuvenate

The ProLon Fasting Mimicking Diet comes with benefits that far surpass other types of diets!

These benefits come from a proprietary mixture of micro and macro-nutrients that work together putting your body into a fasting state while nourishing you for a safe fast that also helps maintain energy levels. You can expect to experience a leaner, more energetic version of yourself.

rejuvenate yourself from within el paso tx.

What To Expect

Fasting State: ProLon is designed to prime your body to transition into a fasting state so it can begin cellular recycling.

Fat Burning: ProLon guides your body to switch to a fat burning state. Cellular clean up (autophagy) begins.

Cellular Recycling: Many people reach a degree of the fat burning metabolic state known as full ketosis.

Cell Regeneration: Autophagy continues and stem cell-based regeneration is ramping up.

Regeneration Continues: Cellular renewal along with the body continue enhancement.

Benefits Continue After The 5 Days

Stem cell-Proliferation begins and continues for up to 5 days after you complete the ProLon Fasting Mimicking Diet and return to a regular healthy diet.

rejuvenate yourself from within el paso tx.

This program was specifically designed knowing people had to be able to stick with it for the full 5-days, which means it has to taste good and fill you up.

ProLon FMD works because:

Designed by professional Italian chefs

Uses the Fasting Mimicking Diet technology

Enjoyable taste, texture, and leaves you feeling satisfied

Get the full benefits of a long fast without giving up food, going too hungry, or quitting early with ProLon.

ProLon� FMD Program | El Paso, TX.

ProLon� FMD Program | El Paso, TX.

Heard about fasting? It is defined as, “abstinence from eating.” What this diet has the potential for in medical benefits has increased quite substantially � both in animal and medical research. Inventor of the Fast Mimicking Diet (FMD) Dr. Longo is recognized as a leading expert on longevity and has done intense work in biochemical pathways. In other words the way cells and we as humans age. This diet can change all that!

What’s all the hype about the FMD?

After years of experimenting with FMD in animal models and showing its benefits on metabolism and life span, Dr. Longo�s team analyzed the effects in human clinical trials. One hundred healthy subjects participated�with half of them following the Prolon FMD five days a month for three months, while the other half ate their regular diet.

  • Profound differences were seen in terms of:
  • Weight loss
  • Visceral fat loss
  • Drop in:
  • Blood pressure
  • Blood sugar
  • Blood cholesterol
  • Markers of inflammation (FMD participants)
  • Drop in insulin-like growth factor 1 (IGF-1); (this is a biomarker for cancer growth).
  • Increase in stem cell production, (this is a marker for cell regeneration).

This diet works by shifting the body�s metabolism and enhancing the power of cells to help protect against chronic diseases like type 2 diabetes and cardiovascular disease. This idea is beginning to catch on: according to a 2018 survey from the International Food Information Council Foundation, intermittent fasting was last year�s most popular diet. Dr. Longo is now studying if a fast-mimicking diet can improve cancer �outcomes and help prevent the disease.

Dr. Longo addresses the point that the more healthy food an individual chooses, the more one can eat. Individuals can still eat fats like pesto, and starches like pasta. The benefits happen when the individual loads up on produce. This brings in more nutrients, more fiber and the feeling of being more full. Dr. Longo is also working on the ability to train an individual’s body to eat within a 12-hour day, which acts as a quick fast overnight.

Los Angeles, Calif.July 31, 2018�On July 10,�L-Nutra, Inc.�became the first company to market a product that has been granted a patent by the�United States Patent and Trademark Office (USPTO)�for optimizing human healthspan, the length of time that a person is healthy. This follows a landmark patent issued in 2016 for treating diabetes and multiple patents previously issued for cancer treatment, but this is the first patented protocol to address health and wellness prior to the onset of disease. The patent is for the Fasting Mimicking Diet� (FMD�), discovered and clinically tested by the�laboratory of Valter Longo�and�Keck Hospital�at the University of Southern California (USC), a nutrition technology that is proven to reduce markers for age-related disease as well as promote tissue regeneration. The Fasting Mimicking Diet is one of few nutri-technologies that has undergone extensive scientific research and clinical trials at major universities across the world. Last year, a landmark human trial published in�Science Translational Medicine�demonstrated that ProLon is clinically proven to reduce markers of the body�s aging process, optimize weight, and maintain healthy levels of multiple metabolic markers such as cholesterol, triglyceride, glucose, and CRP (an inflammatory marker). The secret to the Fasting Mimicking Diet relies on the body�s activation of the epigenetic, metabolic, and cellular reprogramming to survive prolonged periods of fasting. Fasting Mimicking Diet Is Awarded First-Ever Patent for Optimizing Human Healthspan

Interested?

Information

  • Diet Decreases Calorie Intake to 1,100 on Day One
  • Then Around 800 the Next Four Days
  • The program is rich in nuts � so not for those with a nut allergy
  • Nutrients are crucial and are plant-based whole foods:
  • Nuts
  • Olives�(note if don’t like olives)
  • Teas
  • Soup mixes – which are 80% fat, 10% protein, and 10% carbohydrate.
  • During the five days fast:
  • Exercise and Alcohol are prohibited
  • Coffee is limited to zero or one cup a day

How to Use ProLon FMD

Ready?

What to know. To achieve the published results, one will possibly need to go through three cycles at specific times, where they don’t conflict with family/social events like birthdays, weddings, quinceaneras, etc. After three months some will choose to do the program monthly or every other month for long-term health.

Increased Brain Power Study

  • Preliminary studies with FMD showed remarkable brain changes
  • FMD fed to mice four days in a row twice a month:
  • Extended longevity
  • Lowered visceral fat
  • Reduced cancer incidence and
  • Skin Lesions
  • Rejuvenated the immune system
  • Slowed down bone density loss
  • In old mice, FMD cycles promoted:
  • Brain growth
  • Demonstrate improved cognitive performance
  • It is possible that the best brains may result from the least caloric intake for five days a month
Five Day Fasting Mimicking Diet In El Paso, Tx.

Five Day Fasting Mimicking Diet In El Paso, Tx.

El Paso, TX. Chiropractor, Dr. Alexander Jimenez examines how the Fasting Mimicking diet works. What it does, how to take it and the optimal health benefits.

The Diet Where You Fast With Food!

  • The 5 Day Fasting Mimicking Diet�, or FMD, is the first fasting meal program.
  • Made from natural ingredients.
  • Meals are consumed for five days.
  • The body’s ( cellular pathways) do not recognize the meals as food.
  • This keeps the body in a fasting mode.
  • This diet is proven to promote overall health.
  • Reduce excess fat.
  • Allows�you freedom.

Scientifically developed and clinically tested at the Longevity Institute at the University of Southern California. Led by Dr. Valter Longo, the USC Longevity Institute unites multidisciplinary aging research approaches to enhance the healthy years of life.

The FMD is the only meal program that provides the body with optimal nourishment, which keeps the body in fasting mode.

fasting mimicking diet el paso tx.

Take ProLon� What For?

Two decades of scientific discoveries at the University of Southern California.

fasting mimicking diet el paso tx.

Nutritional-Tech

  • All natural, plant-based, high-quality food and supplements
  • Experience the benefits of fasting, but with natural foods
  • Conveniently packaged in single-serve portions for each day of the program

ProLon� Can

  • Decrease body fat
  • Decrease body weight
  • Preserve lean body mass
  • 60% weight loss maintained 3 months after resuming a normal diet

Maintain Levels

  • Blood glucose
  • Blood pressure
  • Cholesterol
  • Triglycerides
  • C-reactive proteins
  • Stem cells Insulin-like growth factor 1 (IGF-1

Meals

The Program Itself

  • Consume the ProLon� meal program�s components for five consecutive days
  • Do not consume any additional food/liquid other than water or herbal teas without caffeine or additives
  • No sodas allowed
  • Resume a healthy diet for the rest of the month

In order to maximize the benefits, you should minimize your consumption of caffeine to 1 cup of coffee or tea without additives or sweeteners per day during the 5-day program.

Resume Normal Healthy Diet

At the end of the program on Day 6

  • Liquid foods, such as soups and fruit juices
  • Light meals: rice, pasta, small portions of fish/meat/legumes
  • Avoid binge eating

Fast Performance

The Expectations?

Individuals taking ProLon� a have reported

  • Improved energy levels
  • Less fatigue
  • Softer and shinier skin
  • A positive impact on lifestyle
  • Making healthier choices and eating less
fasting mimicking diet el paso tx.

How Often Should Somebody Take The 5-Day ProLon� Diet?

The ProLon clinical trials protocol included three consecutive cycles of ProLon (5-day only per month over three consecutive months). It is up to the practitioner to decide the best method that he or she would like to use for each patient. It is suggested that for patients who are obese or overweight, to use ProLon for one three cycle protocol, and recommend that you check with your doctor to re-assess and determine if they have met their goals or if more cycles would be helpful. If a patient is not overweight and eats and exercises well, it is suggested to take the product 1-2 times a year.

Caution

  • Due to the low caloric nature of the ProLon� 5-day meal program, Individuals should not take ProLon� in combination with prescription or non-prescription drugs unless approved by your healthcare professional.
  • Drink at least 8 cups of water to minimize the risk of dehydration.
  • Avoid alcohol consumption, strenuous exercise, and exposure to high temperatures (e.g., saunas, spas, Jacuzzi) or cold environments and swimming.
  • Operate a motor vehicle and heavy machinery with care until it is known how ProLon� may affect you.

Clinical Methodology

Pre-clinical and clinical studies have proven that periodic fasting, done for several days, is a very powerful intervention that our bodies learned to naturally cope with by protecting and rejuvenating itself. The 5-Day ProLon Fasting Mimicking Diet has been clinically tested and found to promote beneficial effects in a wide variety of conditions ranging from excess weight and fasting blood glucose, to growth factors associated with DNA damage and aging.

  • A randomized control trial of 100 subjects
  • 71 completed 3 cycles of the ProLon� either in a randomized phase (N=39) or
  • After being crossed over from a control diet group to the FMD group (N=32)
  • Control subjects continued with a normal diet.
  • ProLon� participants consumed the fasting mimicking diet (FMD) for 5 days per month for 3 months.
  • Measurements were performed prior to the diet (Before) and (During) the recovery period and (After) the 3rd cycle.

fasting mimicking diet el paso tx.

Clinical Results

Elevated Risk Results

ProLon� is clinically tested, an�easy-to-take 5-day meal program that enhances your health without dramatic lifestyle changes

Pre-Clinical Trials

fasting mimicking diet el paso tx.
  • In the first study from the Clinical and Translational Report, yeast deprived of food periodically were shown to have longer life expectancy than yeast fed normally.
  • The second study involved feeding a group of mice a specialized diet for four days a month.
  • The diet reduced both caloric intake and protein intake.
  • The scientists tested markers in the blood of the mice and found that the diet emulated prolonged water-only fasting.
  • After returning to regular feeding, the mice regained most, but not all of the lost weight.
  • Differences between the Fasting Mimicking Diet group and the control group include improved metabolism and cognitive function, gradual weight loss, muscle rejuvenation, higher bone density, 40% fewer malignant lymphomas, immune system regeneration, and longer average life expectancy.

A Third Study

  • There were nineteen participants and nineteen control participants with a broad range of ages (19-75).
  • Members of both sexes and various races so that the study represented a general cross-section of, adult population.
  • The individuals in the Fasting Mimicking Diet group were provided with the food they were required to eat during the five days.
  • Scientists were happy with the compliance level of the diet, and most reported only mild or no negative effects on the fast days.
  • Results showed that the FMD participants experienced an average:
  • 3% reduction in weight
  • Reduction in visceral fat
  • Reduction in C-reactive protein
  • Rejuvenation of the immune system

Those Who Should Not Use ProLon�

  • Children under the age of 18
  • Women who are pregnant or nursing
  • Individuals who are allergic to nuts or soy
  • Individuals with a Body Mass Index (BMI) <18
  • Individuals diagnosed with serious medical condition or disease unless approved in writing by a physician appropriately trained to treat that condition
  • Individuals who have been severely weakened by a disease or medical procedure
  • Individuals who are taking medications which may not be safely consumed with a calorie restricted diet unless authorized in writing by a licensed physician
  • Individuals with Diabetes (type 1 and type 2), cardiovascular disease and cancer, unless approved in writing by a licensed physician. ProLon� should never be combined with glucose-lowering drugs, such as metformin or insulin
  • Fasting is prohibited for individuals with particular metabolic diseases, such as those affecting gluconeogenesis.
  • Individuals with a history of significant cardiac disease, particularly uncompensated congestive heart failure NYHA grade 2 or more or LVEF <40% on any prior assessment
  • Individuals with a history of syncope (fainting) with calorie restriction or other medical co-morbidities Individuals who have special dietary needs that are incompatible with the ProLon� meal plan
  • Individuals with liver or kidney disorders that may be affected by very low glucose and protein content of the diet

Chiropractic Weight Loss Treatment

The Common Benefits of a Ketogenic Diet | Nutrition Specialist

The Common Benefits of a Ketogenic Diet | Nutrition Specialist

The benefits that come from a ketogenic diet are much like those of any strict low-carb diet. The effect may be greater since protein is significantly more restricted. This raises ketones more, and reduces insulin (the fat-storing hormone).

 

Weight Loss

 

Turning your body to some fat-burning machine has clear benefits for weight loss. Fat burning is significantly increased while insulin, the hormone that focuses on fat-storing, drops considerably. This produces the perfect circumstances.

 

About 20 scientific research of the maximum category (RCTs) reveal that, compared to other diets, low-fat and ketogenic diets result in more effective weight reduction.

 

Reverse Type 2 Diabetes

 

A ketogenic diet is excellent for reversing type 2 diabetes, because it lowers blood-sugar levels as well as also helping to reverse the negative effect of elevated insulin levels from this condition.

 

Improved Mental Focus

 

Ketosis ends in a steady stream of gas (ketones) to the brain. And on a ketogenic diet you stay away from swings in blood glucose. This contributes to the experience of concentration and attention.

 

A lot of people use keto diets specifically for improved mental performance. Interestingly, there is a frequent misperception that eating a great deal of carbs6 is necessary for proper brain functioning. When ketones aren’t available but this is only true.

 

Following a couple of times (up to a week) of keto adaptation, through that people can experience some difficulty concentrating, have headaches and be easily irritated, both the human body and mind can run smoothly on ketones.

 

Inside this state, lots of men and women experience more energy and enhanced mental focus.

 

Increased physical endurance

 

Ketogenic diets may vastly increase your physical endurance, by giving you constant access to all of the energy of your own fat stores.

 

The body’s source of stored carbohydrates (glycogen) only lasts for a few hours of intense exercise, or less. But your fat stores hold sufficient energy to easily last for weeks or perhaps months.

 

When you’re accommodated to burning primarily carbs — like most individuals are now — that your fat stores aren’t readily accessible, and they can not fuel your brain. This results in needing to fill up by eating before, during and after exercise sessions that are longer. Or even simply to fuel your everyday activities and prevent “hanger” (hungry and irritable). On a ketogenic diet this dilemma is solved. As the body and brain can be fueled 24/7 from the stores that are powerful, you can keep going.

 

Whether you are competing in a bodily endurance event, or just trying to remain focused on reaching some other target, your body gets the fuel it needs to keep you going and going.

 

Two Problems

 

So how is it possible that the majority of people feel that carbohydrates are essential to do exercise? There are just two reasons. Not, and to unlock the power of ketogenic diets for bodily endurance rather suffer reduced performance, you’ll need:

 

  • Enough fluid and salt
  • Fourteen days of adaptation into burning fat — it does not happen immediately

 

Metabolic Syndrome

 

There are many studies demonstrating that low-carb diets improve markers of metabolic syndrome, such as blood lipids, insulin levels, HDL-cholesterol, LDL particle size and fasting blood sugar levels. Improvements have been demonstrated to be greater when carbs and protein are limited to some the point of becoming.

 

Epilepsy

 

The ketogenic diet is a proven medical therapy for epilepsy that’s been utilized since the 1920s. Traditionally it has been used in children with uncontrolled epilepsy despite drugs.

 

More recently it has also been tested successfully by adults with epilepsy, with similar good results. There are randomized controlled trials that demonstrate the potency of the ketogenic diet in seizures in patients with epilepsy.

 

Employing a ketogenic diet in epilepsy is that usually enables people to take less anti-epileptic drugs, while staying seizure-free. It is not uncommon to even be in a position to completely stop taking these drugs.

 

As a number of medications have side effects, such as nausea, reduced concentration, personality changes or even reduced IQ — being able to shoot less or no medications can be enormously beneficial.

 

More Prevalent Advantages

 

The advantages will be the most frequent ones. However there are many others that are potentially even more unexpected and, at least for some people, lifechanging.

 

The scope of our information is limited to chiropractic and spinal injuries and conditions. To discuss options on the subject matter, please feel free to ask Dr. Jimenez or contact us at 915-850-0900 .�
 

By Dr. Alex Jimenez

 

Additional Topics: Wellness

 

Overall health and wellness are essential towards maintaining the proper mental and physical balance in the body. From eating a balanced nutrition as well as exercising and participating in physical activities, to sleeping a healthy amount of time on a regular basis, following the best health and wellness tips can ultimately help maintain overall well-being. Eating plenty of fruits and vegetables can go a long way towards helping people become healthy.

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What is a Ketogenic Diet? | El Paso Chiropractor

What is a Ketogenic Diet? | El Paso Chiropractor

A ketogenic diet, or keto diet, is a diet, which turns your system into a fat-burning machine. It has some initial side effects towards health and functionality, as well as many advantages for weight loss.

 

A ketogenic diet is comparable to other rigorous low-carb diets, like the Atkins diet plan or LCHF (low carb, higher fat). These diets wind up being ketogenic more or less by accident. The main difference between LCHF and keto is that protein is restricted in the latter.

 

A keto diet plan is made specifically to lead to ketosis. It’s possible to measure and adapt to achieve optimal ketone amounts for wellness or for bodily and psychological performance. Below, you can learn how to use keto to achieve your personal goals.

 

What is Ketosis?

 

The keto in a ketogenic diet stems in the fact that it leaves the body to create small fuel molecules known as ketones. This is an alternate fuel for your body, used when blood sugar (glucose) is in short supply.

 

Ketones are produced if you eat hardly any carbs (that are quickly broken down into blood sugar) and only moderate levels of protein (excess protein can also be converted to blood sugar). Ketones are produced in the liver, from fat. They are then used throughout the entire body as fuel. The brain is an organ which requires a lot of energy to function and fat can’t be used for energy by it. The brain can only run on glucose or ketones.

 

On a ketogenic diet your entire body switches its fuel source to operate almost entirely on fat. Insulin levels become very low and fat burning increases dramatically. It becomes easy to get into your fat stores to burn them off. If you are trying to drop weight, this is obviously excellent, but in addition, there are other benefits, such as less appetite and a continuous supply of energy.

 

Once the body produces ketones, it’s supposedly in ketosis. The quickest way to get there is by fasting, not eating anything, but obviously, it is not feasible to fast. A ketogenic diet, on the other hand, can be eaten forever and also results in ketosis. Without even having to fast, it has many of the benefits of fasting. including weight loss.

 

What to Eat on a Ketogenic Diet

 

Here are typical foods to enjoy on a ketogenic diet. The amounts are net carbs per 100 g. To remain in ketosis, lower is generally better:

 

 

The most essential thing to achieve ketosis is to stay away from eating most carbohydrates. You will need to keep intake ideally under 20 grams but under 50 grams per day of carbs is accepted. The fewer carbs the more successful.

 

Try to avoid

 

Here is what you shouldn’t eat on a keto diet, meals full of sugar and starch, including starchy foods such as bread, rice, pasta and potatoes. These foods are much higher in carbohydrates, as you can see.

 

What is Ketosis Image 2

 

The amounts are g of digestible carbs per 100 g (3.5 oz), unless otherwise noticed.

 

This usually means you will want to completely prevent sweet sugary foods, also starchy foods such as bread, pasta, rice and potatoes. Basically follow the guidelines to get a diet that is low-carb that is rigorous, and remember it is assumed to be full of fat, not high in protein.

 

A rough guideline is under 10 percent energy from carbs (the fewer carbs, the more successful), 15 to 25 percent protein (the lower end is more successful), and 70 percent or more from fat.

 

What to Drink on a Ketogenic Diet

 

What is Ketosis Image 3

 

So what do you drink on a keto diet? Water is ideal, and so is tea or coffee. Use no additives. A small amount of milk or cream is OK (but beware of caffe latte!) . The glass of wine is fine.

 

How Low is Keto?

 

The fewer carbohydrates you consume, the larger the effects on fat and blood sugar will be. A keto diet is a strict low-carb diet, and consequently highly effective.

 

We recommend following the dietary advice as strictly as you can. When you are contented with your weight and health, you might carefully try eating more liberally (if you would like to).

 

The scope of our information is limited to chiropractic and spinal injuries and conditions. To discuss options on the subject matter, please feel free to ask Dr. Jimenez or contact us at 915-850-0900 .�Green-Call-Now-Button-24H-150x150-2.png

 

By Dr. Alex Jimenez

 

Additional Topics: Wellness

 

Overall health and wellness are essential towards maintaining the proper mental and physical balance in the body. From eating a balanced nutrition as well as exercising and participating in physical activities, to sleeping a healthy amount of time on a regular basis, following the best health and wellness tips can ultimately help maintain overall well-being. Eating plenty of fruits and vegetables can go a long way towards helping people become healthy.

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Intermittent Fasting, Cortisol and Blood Sugar | Science Chiropractor

Intermittent Fasting, Cortisol and Blood Sugar | Science Chiropractor

There’s been a lot of discussion about the advantages of intermittent fasting (IF) in the community lately. Paul Jaminet mentions its role in the function of the metabolism as well as it’s role in boosting the immune system. In his novel, Health Diet, he discusses how IF may be helpful for those attempting to shed weight, among other benefits.

 

Intermittent fasting is an eating pattern where you cycle between times of fasting and eating. It does not state anything about which foods to eat, but instead when they should be eaten by you. There are numerous different fasting methods, all of that which split the days and weeks to eating intervals and fasting intervals.

 

Most people fast; daily, while they sleep. Fasting is often as easy as stretching that. You can drink water, coffee, tea and other non-caloric drinks, although no food is permitted during the fasting period. Some forms of intermittent fasting allow small amounts of low-calorie foods . Taking supplements is generally allowed while fasting, as long as there are no calories in them.

 

From an evolutionary perspective, intermittent fasting has been likely the ordinary state of affairs. There were no restaurants, no grocery stores or convenience stores, and food was not nearly as readily accessible or easy to come by as it is today. Nor were there watches, lunch breaks, programs or the sort of construction and routine we have in today’s world. This means it is very likely that our paleo ancestors had days when they ate lightly or did not eat, and possibly did move 12-16 hours between meals on a regular basis.

 

Therefore, while intermittent fasting is a part of our legacy, and that it can be useful in certain situations, Its not believed to be a suitable strategy for everyone. Why? Because cortisol levels can be elevated due to fasting. One of cortisol’s effects is that it raises blood glucose. In someone with blood glucose regulation difficulties, fasting can make them worse.

 

This has been seen again and again with many patients. Many patients have blood sugar imbalances. And it is usually not as straightforward as “high blood sugar” or “low blood sugar”. They frequently have a combination of both (reactive hypoglycemia), or strange blood sugar patterns which, on the outside, do not make much sense. These folks are not currently eating a Standard American Diet. Most of them are on a paleo-type or low-carb dietplan. Yet they have blood sugar issues.

 

In these cases, cortisol dysregulation is almost always the culprit. Whenever these patients try fasting, their blood sugar management gets worse. Its been frequently observed that blood sugar readings in the 90s and even low 100s are recorded from fasting, in spite of the fact that they are eating a low-carb, paleo-type diet.

 

That’s why intermittent fasting is often not recommended for those who have blood sugar regulation issues. Instead, its suggested that they eat every 2-3 hours. This helps to maintain stable blood sugar during the day and prevents cortisol and other stress hormones like epinephrine and norepinephrine from becoming involved. When patients that have been fasting and experiencing high blood sugar readings switch to eating this way, their blood sugar numbers almost always hastens.

 

There’s a controversial standpoint about how eating every 2-3 hours is “normal” in the evolutionary view. But neither is driving in traffic or staying up till 2:00am on Facebook. It’s not a set of rules, although the paleo template is there to direct us. This should also be a reminder that there’s no “one size fits all” approach when it comes to healthcare. Successful therapy depends on addressing them and identifying the underlying mechanisms.

 

The scope of our information is limited to chiropractic and spinal injuries and conditions. To discuss options on the subject matter, please feel free to ask Dr. Jimenez or contact us at 915-850-0900 .�
 

By Dr. Alex Jimenez

 

Additional Topics: Wellness

 

Overall health and wellness are essential towards maintaining the proper mental and physical balance in the body. From eating a balanced nutrition as well as exercising and participating in physical activities, to sleeping a healthy amount of time on a regular basis, following the best health and wellness tips can ultimately help maintain overall well-being. Eating plenty of fruits and vegetables can go a long way towards helping people become healthy.

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Purpose of Intermittent Fasting, According to Science | El Paso

Purpose of Intermittent Fasting, According to Science | El Paso

Intermittent fasting is not a diet, but a diet program that is supposed to accelerate fat loss and muscle development compared to traditional eating schedules. It is promoted primarily from the scientific community, however, there are no scientific research (as of February 2014) who have affirmed intermittent fasting to gaining muscle while losing weight.

 

With metabolic restriction, intermittent fasting may lead to weight reduction. In a recent review (Varady, 2011) and a recent randomized clinical trial (Harvie et al., 2011), many writers concluded that intermittent fasting and daily caloric restriction are equally effective at promoting weight loss in overweight and obese individuals. No research to date has been performed with athletes that require upkeep of strength, muscular size, and function.

 

Intermittent Fasting Approach & Scientific Support

 

There have been many suggested methods for intermittent fasting, from skipping a single meal daily to eating only every other day. The majority of these diets are encouraged through webpages, blogs, and books published by exercise and diet enthusiasts.

 

Up to now, regardless of the focused marketing of intermittent fasting into the athletic community, there are just a few well-controlled, scientific research exploring the effects of intermittent fasting on the body composition and performance in athletes. Currently, the majority of the scientific evidence for the health benefits of intermittent fasting has arrived from animal studies (Longo and Mattson, 2014) and the unwanted effects of intermittent fasting have originated from Muslim athletes throughout Ramadan (review: (Chaouachi et al., 2009), both with restricted ability to be translated into the overall athletic community. Even more and more human research have been conducted to confirm claims discovered in animals, many studies have been with patients with a certain illness or condition (ex. Rheumatoid arthritis, hypertension, and obesity) rather than in healthy, energetic individuals.

 

Similarities Among Strategies

 

The different intermittent fasting approaches tend to emphasize their differences (and therefore purported superiority) however, there are also many similarities. Among the advantages of the form of caloric control is that it allows people. Instead of linking “appetite” with “panic” or even “want” (Ganley 1989), “hunger” can theoretically be newly associated with “achievement” or “pride”, or simply dismissed.

 

Really, with any method, there’s a critical transition period of approximately 3-6 weeks through which the human body and mind adapt to the new eating schedule (Longo and Mattson, 2014). This period can be extremely uncomfortable, as restricted eating was anecdotally associated with intense hunger, irritability, loss of stamina, loss of libido, along with other unwanted side effects (Dirks and Leeuwenburgh 2006; Johnstone 2007; Heilbronn, Smith, et al. 2005). When the body is accustomed, however, the hunger levels may decrease and disposition might become more favorable in contrast to prior to the program began. Elevated mood and diminished hunger on caloric restrictive diets are noted in some (Wing et al. 1991) although not all (ex. (Heilbronn, Smith, et al., 2005) research.

 

Intermittent fasting isn’t a weight loss program per se; only if calories are restricted will somebody lose weight. Although intermittent fasting is one way to limit intake of total calories to achieve weight loss (Varady et al., 2009; Varady, 2011; Harvie et al., 2011), there have not been any studies to date on athletes who prioritize maintenance of muscle size and strength. In actuality, there are conflicting views on whether intermittent caloric limitation. daily calorie restriction greatest maintain lean muscle mass (Varady, 2011; Johnstone, 2007).

 

All of these approaches emphasize the value of the nutritional quality of the meals that are consumed. Nutrients like fiber, fat, protein, vitamins, and minerals are crucial for good health and, because nutrients aren’t consumed while fasting, they are especially important when breaking the fast. Additionally, drinking a lot of water has been encouraged both to stay hydrated and to alleviate hunger. John Berardi of Precision Nutrition (see “More info”) allows green powders, green tea, and branched chain amino acids during his quick, but it’s unknown how these supplements influence appetite, energy levels, muscle synthesis/breakdown, or the general advantages of intermittent fasting.

 

Exercising and Intermittent Fasting

 

All intermittent fasting approaches can be damaging to athletic gains for several reasons. To begin with, meals in close proximity to your workout are essential for optimal performance, healing, and muscle gain (Aragon and Schoenfeld, 2013). Secondly, greater appetite sensations can hinder compliance in addition to increase the potential to over-consume meals when it becomes available (Hawks and Gas,t 1998). Despite the frequent belief that you will burn off more fat if you exercise while firming, performing aerobic exercise in the fasted state is not recommended (review: (Schoenfeld 2011)). Actually:

 

  • Performing aerobic exercise following consuming carbohydrates doesn’t hinder fat oxidation (Febbraio et al., 2000; p Bock et al., 2008),
  • Performing aerobic exercise fasted will also promote reduction of lean muscle mass, since muscle will be burned for fuel (Lemon and Mullin, 1980),
  • Exercising at a fasted state often does not result in an optimal exercise. In contrast, having readily available energy will allow optimal performance that will burn off more calories overall and lead to the Greatest gains (Loy et al., 1986; Schabort et al., 1999),
  • Exercising at the fasted condition, fed state reduces static and dynamic balance and can increase the risk of harm (Johnson and Leck, 2010).

 

There are fewer studies investing the effects of doing resistance training in the fasted vs. fed state, but it is anticipated that the same points hold true.

 

Intermittent fasting recommends consuming at least 5 grams BCAAs before a workout when exercising during your fasting period. There’s no proof substantiating that claim, although this bolus of BCAAs in your blood flow theoretically could help maintain muscle protein throughout the exercise. In one study, a BCAA infusion prior to a workout in the fasted state failed to enhance performance in one set of individuals onto a rated incremental exercise test (Varnier et al., 1994). So that you can enjoy a complete meal that is post-workout advocates also advise to program your schedule, but they tend to dismiss the importance for pre-workout nourishment.

 

As you can see, all diet programs share a frequent theme of compartmentalizing “fasting” and “eating” periods. Because there is no one method that’s best so many versions of those diets exist. Further, some individuals who attempt fasting use a hybrid of present approaches to discover a technique that is successful.

 

Most importantly, intermittent fasting isn’t suggested for pregnant women, women that are breastfeeding, people with diabetes, or other people who wish to closely regulate their blood sugar. In addition, there has not been a study on participants that are underweight, very old, or very young.

 

The scope of our information is limited to chiropractic and spinal injuries and conditions. To discuss options on the subject matter, please feel free to ask Dr. Jimenez or contact us at 915-850-0900 .�
 

By Dr. Alex Jimenez

 

Additional Topics: Wellness

 

Overall health and wellness are essential towards maintaining the proper mental and physical balance in the body. From eating a balanced nutrition as well as exercising and participating in physical activities, to sleeping a healthy amount of time on a regular basis, following the best health and wellness tips can ultimately help maintain overall well-being. Eating plenty of fruits and vegetables can go a long way towards helping people become healthy.

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TRENDING TOPIC: EXTRA EXTRA: New PUSH 24/7�? Fitness Center

 

 

The Science Behind Intermittent Fasting | Nutrition Specialist

The Science Behind Intermittent Fasting | Nutrition Specialist

Though the truth has a tendency to get distorted by time, diet and exercise tendencies have origins in science. Benefits are exaggerated. Hazards are downplayed. Meanwhile science takes a back seat to marketing.

 

An individual need not look any farther than the emerging tendency of intermittent fasting for a prime illustration. Advocates for taking breaks from eating, for up to 24 hours a week, tout it as a safe and effective method for improving health and wellness. That message has been reaching more and more ears as of late.

 

“Right now, we are in a vital juncture for fasting,” states Brad Pilon, an expert on occasional fasting and author of the novel Eat Stop Eat. “It’s becoming extremely popular.”

 

Intermittent Fasting: Know the Facts

 

Such may become so popular, in fact, that it’s moving into trend territory, indicates Pilon. And if something becomes a fad, only for a short period although intensely popular, several problems normally ensue. For one, he states, nutrition experts and many doctors have a tendency toward dismissing fads from hand. So clients and their patients, while shielded from the claims of dieting evangelists that are overzealous, can lose out on the advantages of fasting right.

 

Yet another concern is that promoters of intermittent fasting will, perhaps unintentionally, encourage extreme behaviour, such as bingeing. This is reflected in the photos accompanying many recent new articles on “the fast diet” or even the “5:2 diet.” Often, they portray people eating loads of high-calorie, high-fat foods, like hamburgers, french fries and cake. The implication being that if you fast two days a week, you are able to consume a lot during the remaining five days.

 

Not so, say more moderate proponents of fasting. Their take on intermittent fasting: eat sensibly the majority of the time, eat nothing for a protracted period every now and then, gratify only on occasion (maybe once a week, state, on a predetermined “cheat day”). There is study, they assert, to back up the health benefits of wisely.

 

There is indeed a large body of research to support the health benefits of fasting, although most of it has been conducted on animals, not humans. Still, the results have been promising. Fasting has been shown to improve biomarkers of illness, decrease stress and preserve memory and learning function, based on Mark Mattson, senior investigator at the National Institute on Aging, part of the US National Institutes of Health. Mattson has investigated the health advantages of intermittent fasting on the cardiovascular system and brain in rodents, also has known for “well-controlled human studies” in people “across a assortment of body mass indexes” (J Nutr Biochem 2005;16:129–37).

 

There are several theories about why fasting offers physiological advantages, says Mattson. “The one which we have researched a great deal, and designed experiments to examine, is the hypothesis that during the fasting period, cells are under a mild strain,” he states. “And they respond to the stress adaptively by enhancing their ability to deal with additional stressors and, possibly, to resist illness.”

 

Although the term “stress” is frequently used in a negative sense, taxing the body and mind has benefits. Consider exercise, which stresses, in particular, muscles and the cardiovascular system. So long as you give the body time to recover, it will grow stronger. “There is considerable similarity between how cells react to the pressure of exercise and how cells react to intermittent fasting,” says Mattson.

 

Additional Research: Intermittent Fasting

 

Mattson has contributed to several additional research on intermittent fasting and caloric restriction. In one, obese adults with moderate asthma consumed only 20% of their normal calorie intake on alternative days (Free Radical Bio Med 2007;42:665–74). Participants that stuck to the diet lost 8 percent of their initial body weight over eight months. They also found a decrease in markers of oxidative stress and inflammation, and improvement of several indicators and asthma-related symptoms.

 

In another study, Mattson and colleagues researched the effects of intermittent and continuous energy limitation on weight loss and various biomarkers (such as conditions such as breast cancer, diabetes and cardiovascular disease) among young obese woman (Int rheumatoid arthritis 2011;35:714–27). They discovered for improving weight loss, insulin sensitivity and other wellness biomarkers that restriction was as effective as continuous restriction.

 

Mattson has also investigated the protective benefits of fasting to neurons. Should youn’t eat for 10 – 16 hours, then your body will go for energy, and fatty acids called ketones will probably be released into the bloodstream. It has been demonstrated to protect memory and learning says disease processes in the mind, as well as Mattson.

 

But maybe it isn’t so much that the fasting that creates health benefits, per se, because the consequent overall reduction in calorie intake (if, in other words, you don’t overeat on nonfasting days, which could cause a caloric surplus rather than a deficit). That seems, at least, to be true in slowing diseases like cancer in mice, according to Dr. Stephen Freedland, associate professor of urology and pathology at the Duke University Medical Center in Durham, North Carolina.

 

“Caloric restriction, undernutrition without malnutrition, is the only experimental approach consistently shown to prolong survival in animal models,” Freedland and colleagues stated in a study on the effects of intermittent fasting on prostate cancer growth in mice (Prostate Cancer Prostatic Dis 2010; 13:350–5). From the study, mice fasted twice weekly for 24 hours, but were otherwise permitted to eat at liberty. During days, the mice overate. They did not lose weight. Intermittent fasting using compensatory overeating “did not enhance mouse success nor did it delay prostrate tumor growth,” the study concluded.

 

To improve health, the aim should be to shed weight by reducing the entire amount of calories consumed, indicates Freedland, rather than focusing on if those calories are consumed. “If you [do not] eat two days every week, and restrict what you eat another five days, you will lose weight. It is one approach to losing weight,” he says. “I am not sure it works any better than trimming down marginally seven days each week.”

 

People should also be skeptical of books written for wide audiences that describe the science behind fasting or another health trend, ” he says. One purpose of writing a novel for the consumer market, after all, would be to sell as many copies as you can. Authors tend to present evidence, while ignoring the facts and their impact. “It has a whole lot of spin when you compose a book.”

 

The scope of our information is limited to chiropractic and spinal injuries and conditions. To discuss options on the subject matter, please feel free to ask Dr. Jimenez or contact us at 915-850-0900 .�
 

By Dr. Alex Jimenez

 

Additional Topics: Wellness

 

Overall health and wellness are essential towards maintaining the proper mental and physical balance in the body. From eating a balanced nutrition as well as exercising and participating in physical activities, to sleeping a healthy amount of time on a regular basis, following the best health and wellness tips can ultimately help maintain overall well-being. Eating plenty of fruits and vegetables can go a long way towards helping people become healthy.

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