Autoimmunity:�One of the most common things is to leave the doctor�s office with a diagnosis of an autoimmune disease and no nutritional or lifestyle changing insight. Autoimmune diseases are related to inflammation. Keeping� the inflammation down is the goal with autoimmune attacks. The foods you eat make a huge difference in the frequency and severity of flare-ups. Steady dietary changes can help you reach your optimal self.
Contents
Is Autoimmune Disease A Result Of The Collective Perturbations Of The Exposome & Its Impact On The Immunometabolic System?
The Exposome
Semin Arthritis Rheum. 2018; 47(5): 710?717.
Exposome Influence On SLE
The Ecology Of The Exposome
Exposome & The Alteration Of �Self�
The Exposome Connections To Autoimmune Diseases Converting Self Into Non?Self
- Immunometabolic dysfunctions through diet and lifestyle imbalances
- Gut Ecology and the Microbiome
- ViralorBacterialInfections
- Hormones
- Drugs
- Chemicals
- IonizingRadiation
- PsychologicalStress
FEBS Lett. 2017 Oct;591(19):3119?3134.
Cell. 2018 Jan 11;172(1?2):22?40.
Cross?Talk Among The Endocrine, Immune & Metabolic Systems
Multi?Organ Network Biology
In Autoimmunity, Warburg Metabolism Is Increased Through Increased Activity Of GAPDH
Science. 2018; 360: 377?78. Dietary Influence?
Blocking Immune Cell Glycolysis & �Starving� Its Function
Ketogenic Diet�s Potential Impact On GAPDH Immunometabolic Regulation
Cell. 2018 Jan 11;172(1?2):162?175.
Front Immunol. 2017 Mar 21;8:311.
Origin Of IL?17 Producing Th17 Cells
What Is The Relationship Of The Gut Microbiome To Autoimmune Disease?
www.cell.com/cell/issue?pii=S0092-8674(17)X0006-8%5B/caption%5D
Science. 2018 Mar 9;359(6380):1097?98.
Science. 2018 Mar 9;359(6380):1156?61.
Allergol Int. 2018 Jan 6;67(1):32?42.
Int J Mol Sci. 2015 Sep 1;16(9):20841?58.
Science. 2018 Mar 9;359(6380):1151?56.
High Fiber Influences On Diabetes In Animal Model
80% Of Patients With Autoimmune Disease Are Female
Why?
Estrogen & Autoimmunity
- The greatest association with autoimmune diseases is the female gender
- 17?beta estradiol seems to play a role in activating T cells in autoimmune disease
- T cells have ER?alpha receptors that are activated by 17?beta estradiol resulting in the production of inflammatory cytokines
- Blocking ER?alpha receptors may have a beneficial effect on autoimmune activation
Sci Signal. 2018 Apr 17;11(526). piieaap 9415
Eleanor Rogan, PhD IFM Linus Pauling Award Winner
www.JeffreyBland.com
Estrogen & Androgen Metabolism
4?Hydroxyestrogens & DNA reactivity
www.ncbi.nlm.nih.gov/pubmed/22155198%5B/caption%5D
www.ncbi.nlm.nih.gov/pubmed/21432907%5B/caption%5D
Indole?3?Carbinol (I3C) Inhibition Of ER?Alpha
www.ncbi.nlm.nih.gov/pubmed/27312859%5B/caption%5D
Relationship Of Hepatic Drug Detoxification To Anti?Nuclear Antibody Development
onlinelibrary.wiley.com/doi/pdf/10.1002/art.1780240805%5B/caption%5D
www.ncbi.nlm.nih.gov/pubmed/24763537%5B/caption%5D
Biomed Res Int. 2015;2015:194031.
www.ncbi.nlm.nih.gov/pmc/articles/PMC4365752/%5B/caption%5D
www.ncbi.nlm.nih.gov/pubmed/18995849%5B/caption%5D
www.ncbi.nlm.nih.gov/pubmed/24530186%5B/caption%5D
Making Friends With Ourselves: Clinical Implications
- Reduce exposure to agents that activate immunometabolic dysfunction through the exposome
- � Dietary
- � Infection
- � Parasites
- � Xenobiotics
- � Hormone
- � Allergy
- � Specific medications
- � Dysbiosis
- Reduce exposure to DNA damage (radiation, chemicals)
- Support hepatic detoxification
- Implement gastrointestinal restoration program
- Reduce metabolic inflammation and endotoxin
- Reduce psychological stress factors that activate HPA axis
Jeffrey Bland, PhD
Chairman Emeritus & Member, Board of Directors The Institute for Functional Medicine
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The information herein on "Is It Really Autoimmunity? | El Paso, TX. | Part II" is not intended to replace a one-on-one relationship with a qualified health care professional or licensed physician and is not medical advice. We encourage you to make healthcare decisions based on your research and partnership with a qualified healthcare professional.
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