Back Clinic Gut and Intestinal Health. The health of an individual’s gut determines what nutrients are absorbed along with what toxins, allergens, and microbes are kept out. It is directly linked to the health of the whole body. Intestinal health could be defined as optimal digestion, absorption, and assimilation of food. But this is a job that depends on many other factors. More than 100 million Americans have digestive problems. Two of the top-selling drugs in America are for digestive problems, and they run in the billions. There are more than 200 over-the-counter (OTC) remedies for digestive disorders. And these can and do create additional digestive problems.
If an individual’s digestion is not working properly, the first thing is to understand what is sending the gut out-of-balance in the first place.
A low-fiber, high-sugar, processed, nutrient-poor, high-calorie diet causes all the wrong bacteria and yeast to grow in the gut and damages the delicate ecosystem in your intestines.
Overuse of medications that damage the gut or block normal digestive function, i.e., acid blockers (Prilosec, Nexium, etc.), anti-inflammatory medication (aspirin, Advil, and Aleve), antibiotics, steroids, and hormones.
Undetected gluten intolerance, celiac disease, or low-grade food allergies to foods such as dairy, eggs, or corn.
Chronic low-grade infections or gut imbalances with overgrowth of bacteria in the small intestine, yeast overgrowth, parasites.
Toxins like mercury and mold toxins damage the gut.
Lack of adequate digestive enzyme function from acid-blocking medications or zinc deficiency.
Stress can alter the gut’s nervous system, cause a leaky gut, and change the normal bacteria.
Visits for intestinal disorders are among the most common trips to primary care doctors. Unfortunately, most, which also includes most doctors, do not recognize or know that digestive problems wreak havoc in the entire body. This leads to allergies, arthritis, autoimmune disease, rashes, acne, chronic fatigue, mood disorders, autism, dementia, cancer, and more. Having proper gut and intestinal health is absolutely central to your health. It is connected to everything that happens in the body.
Cardiovascular disease,�also called heart disease, involves numerous issues,�including diseased vessels, structural problems, and blood clots. High blood pressure, or hypertension, occurs when your blood pressure increases to unhealthy levels. Your blood pressure measurement takes into account how quickly blood is passing through your veins and the amount of resistance the blood meets while it’s pumping.
What are the leading causes of cardiovascular disease and hypertension?
Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease.�In a series of research studies correlated to cardiovascular disease and hypertension, Dr. Mark C. Houston, MD, discussed the role that oxidative stress, inflammation and autoimmune dysfunction plays in relation to treatment of hypertension and cardiovascular disease.
Oxidative Stress
Oxidative stress, with an imbalance between the defense mechanisms and RNS as well as ROS, contributes to the etiology of hypertension in humans and animals. Radical oxygen species and RNS are generated by numerous mobile sources, such as nicotinamide adenine dinucleotide phosphate hydrase (NADPH) oxidase, mitochondria, xanthine oxidase, uncoupled endothelium-derived nitric oxide (NO) synthase (U-eNOS), cyclo-oxygenase and lipo-oxygenase. Superoxide anion is your predominant ROS species produced with these tissues, which inhibits NO and also leads to downstream production of additional ROS (As seen in Figure 3).
Patients have impaired an oxidative stress reaction to several stimuli, an elevated plasma oxidative stress and exogenous and endogenous antioxidant defense mechanisms. Hypertensive subjects also have lower plasma ferric reducing ability of plasma vitamin C levels and increased plasma 8-isoprostanes, which correlate with both diastolic and systolic BP. Different single-nucleotide polymorphisms (SNP’s) in genes that codify for antioxidant enzymes are directly linked to hypertension. These include NADPH oxidase, xanthine oxidase, superoxide dismutase 3 (SOD 3), catalase, glutathione peroxidase 1 (GPx 1) and thioredoxin. Antioxidant deficiency and excess free radical production have been implicated in human hypertension in several epidemiologic, observational and interventional studies (Table 2).
Radical oxygen species directly damage endothelial cells, degrade NO, influence eicosanoid metabolism, oxidize LDL, lipids, proteins, proteins, DNA and natural molecules, boost catecholamines, harm the genetic machinery, affect gene expression and transcription factors. The interrelations of systems, oxidative stress and cardiovascular disease are shown in Figures 6 and 7. The increased oxidative stress, inflammation and autoimmune vascular dysfunction in human hypertension results in a combination of an response to ROS and RNS increased generation of ROS and RNS and a decreased antioxidant reserve. Increased oxidative stress from the rostral ventrolateral medulla (RVLM) enhances glutamatergic excitatory inputs and attenuates GABA-ergic inhibitory inputs into the RVLM which contributes to increased sympathetic nervous system (SNS) activity from the paraventricular nucleus. Activation of this AT1R in the RVLM raises NADPH oxidase and increases oxidative stress and superoxide anion, increases SNS outflow causing an imbalance of SNS/PNS action with elevation of BP, increased heartbeat and alterations in heart rate variability and heart rate recovery time, which can be obstructed by AT1R blockers.
Inflammation
The link between hypertension and inflammation was suggested in both longitudinal and cross-sectional studies. Raised in high sensitivity C-reactive protein (HS-CRP) and other inflammatory cytokines such as interleukin-1B, (IL-1B), IL-6, tumor necrosis alpha (TNF-?) and chronic leukocytosis occur in hypertension and hypertensive-related TOD, such as increased carotid IMT. HS-CRP predicts CV events. Elevated HS-CRP is risk factor and a risk marker for hypertension and CVD. Increases in HS-CRP of over 3 ?g/mL can increase BP in only a couple of days that is directly proportional to the increase in HS-CRP. ENOS and nitric oxide are inhibited by HS-CRP. HS-CRP, down-regulates the AT2R, that counterbalances AT1R. Angiotensin II (A-II) upregulates many of those cytokines, notably IL-6, CAMs and chemokines by activating nuclear factor Kappa B (NF-?B) resulting in vasoconstriction. These events, as well as the increases in endothelin-1 and oxidative stress, elevate BP.
Autoimmune Dysfunction
Innate and adaptive immune responses are associated with hypertension and hypertension-induced CVD through at least three mechanisms: central nervous system stimulation cytokine generation and renal impairment. This includes salt-sensitive hypertension with dysregulation of both CD4+ and CD8+ lymphocytes increased inflammation because of T cell imbalance and chronic leukocytosis with increased neutrophils and lymphocytes that are decreased. Leukocytosis, especially neutrophils and decreased lymphocyte count raise BP in Blacks by. Macrophages and invade the wall, trigger TLRs, various subtypes govern BP and cause autoimmune vascular damage. Angiotensin II activates immune cells (T cells, macrophages and dendritic cells) and promotes cell infiltration into target organs. CD4+ T lymphocytes express AT1R and PPAR gamma receptors, and release TNF-?, interferon and interleukins inside the vascular wall when triggered (Figure 5). May play a role in the genesis of hypertension brought on by Angiotensin II. Patients have higher TLR 4 mRNA in monocytes in comparison to normal. Intensive decrease in BP to systolic BP (SBP) less than 130 mmHg vs SBP to just 140 mmHg reduces the TLR 4 longer. A-II activates the TLR expression resulting in inflammation and activation of the innate immune system. When TLR 4 is triggered there is downstream macrophage activation, increase metalloproteinase 9, migration, vascular remodeling, collagen accumulation in LVH the gut and cardiac fibrosis. The autonomic nervous system is essential in either increasing or decreasing inflammation and immune dysfunction. Efferent cholinergic pathways through the nerve innervate the spleen, nicotine acetylcholine receptor subunits and cytokine producing immune cells to BP and affect vasoconstriction. Nearby CNS inflammation or ischemia may mediate vascular hypertension and inflammation.
Aldosterone is correlated with increased adaptive immunity and autoimmune responses with CD4+ T cell activation and Th 17 polarization with improved IL 17, TGF-? and TNF-? which modulate over 30 inflammatory genes. Serum aldosterone is also an independent risk factor for CVD and CHD via non-hemodynamic effects as well as through increased BP. Blockade of receptors in brain, the heart, blood vessels and immune cells reduces CV danger even with the persistence of hypertension.
In conclusion, cardiovascular disease and hypertension have been associated with numerous issues, however, oxidative stress, inflammation and autoimmune dysfunction have been regarded as the most prevalent causes behind cardiovascular disease and hypertension.�Oxidative stress, defined as a disturbance in the balance between the production of reactive oxygen species (free radicals) and antioxidant defenses, inflammation and autoimmune dysfunction, occurs�when the body’s immune system attacks and destroys healthy body tissue by mistake. Cardiovascular disease and hypertension is an indication of cardiovascular issues which should be addressed by a healthcare professional.
The scope of our information is limited to chiropractic and spinal injuries and conditions. To discuss options on the subject matter, please feel free to ask Dr. Jimenez or contact us at 915-850-0900 .�
By Dr. Alex Jimenez
Additional Topics: Wellness
Overall health and wellness are essential towards maintaining the proper mental and physical balance in the body. From eating a balanced nutrition as well as exercising and participating in physical activities, to sleeping a healthy amount of time on a regular basis, following the best health and wellness tips can ultimately help maintain overall well-being. Eating plenty of fruits and vegetables can go a long way towards helping people become healthy.
Many people with diabetes are extremely conscious about their health, for this reason, they are continuously looking for ways to handle their diabetes more efficiently. However,how can they make a difference if they do not even understand the disease they are currently suffering from? Some factors are thought to cause this and make it even worse.
Leaky gut is one of those ailments; some also theorize that without a leaky gut, you can’t actually have type 2 diabetes. Not only could it cause diabetes, but it may perpetually make it even worse.
What is Leaky Gut?
Leaky gut can be called “intestinal hyperpermeability”. In simpler terms, it means that toxins on your gut may pass through the intestines and also leak in your entire body. As can be anticipated, this causes lots of medical problems.
Basically, leaky gut occurs when your digestive tract is weak in the poor diet, among other factors. The intestines worn and are currently thinning down. The “good bacteria” which assist you in breaking down your food and eliminating toxins are not flourishing. Leaky gut allows toxins to reside in the body which should have been expelled quite quickly, causing symptoms such as these:
Inflammation (sometimes severe)
Inflammatory bowel disease (Crohn and ulcerative colitis)
Irritable bowel syndrome
Food allergies
Chronic fatigue
Hepatitis
Pancreatitis
Arthritis
Diarrhea
Joint pain
Skin rash
Diabetes
AIDS
With such a lengthy list of conditions related to your leaky gut, you might begin to think it is a super-disease or something. Do not worry, it is not. Though it contributes to or causes some messed up stuff inside your body, it’s avoidable and even reversible. Some professionals even believe you could reverse severe and chronic disease (such as diabetes) by preventing that leaky gut.
You won’t discover much about leaky gut from mainstream physicians. Most doctors do not even test this yet. It is really somewhat of a mystery to most medical professionals. Linda A. Lee, MD, a gastroenterologist in John Hopkins Integrative Medicine and Digestive Center says “We do not understand a good deal, but we know that it exists.” She proceeds. “In the absence of evidence, we do not know… what treatments may directly address it.”
Other specialists, such as Donald Kirby, MD, refer to a leaky gut as a “very grey area”. Itself is a diagnosis of a disorder, it means that more research needs to be done, and an individualized diagnosis has to be made. What exactly does that mean? It usually means that the root of leaky gut can be any number of items, so you want to discover the cause. On this note, let’s take a look at some of these triggers.
What Causes Leaky Gut?
To reiterate, there isn’t any one conclusive cause due to the shortage of research done. However, there are a number of items upon this could give rise to your intestines getting weak, ineffective, and leaky agreed. These include:
Excessive alcohol usage (which can irritate the intestinal wall)
Enzyme deficiency (like having lactose-intolerance)
Toxic metals
Aspirin, ibuprofen, and other anti-inflammatory drugs
Chemotherapy and radiation therapy
Your gut has a great deal of difficult work to do. Not only does it need to digest and break it down into nutrients to nourish your body, in addition, it has to guard you from toxins which would otherwise put in your bloodstream and of the waste products. This heavy responsibility warrants that we take care of our bowels. Unfortunately, the greater bulk of people today don’t even give a second thought.
Your typical American diet is filled with sugary soft drinks, white flour, and otherwise high tech, low-fiber foods. This leads to an unhealthy gut in which germs are useless and weak while bacteria flourish and harm your intestines. The walls of your intestines begin to neglect when the damage is too severe. They become permeable and start to permit the toxins and waste, so which was intended to remain right into your bloodstream.
Some of those other items on the above list, such as alcohol and some prescription and over-the-counter medications, also have a negative effect on the internal flora of your intestines. You have a harder time fighting the things that pass through it and digesting your food if the good bacteria is killed off in your gut. Your gut can begin to leak and becomes unhealthy as the good bacteria make way for bacteria.
How Exactly is Leaky Gut Connected to Diabetes?
To provide you the most shocking news first: new study suggests that you can have each of the genetic predispositions to diabetes in the world, however you’ll never really contract diabetes unless you’ve got a leaky gut also. This means (if this study is correct) for those who have diabetes, then you already have a leaky gut.
The largest link between migraines, leaky gut and diabetes is inflammation. Inflammation is involved with developing type 2 diabetes. In fact, many disorders are associated with inflammation such as:
Periodontal disease
Stroke
Heart disease
Insulin resistance and Type 2 diabetes
When toxins leak from your intestines and in your bloodstream, this causes an immune response from the human body. The modest cells that your body sends out do their best to remove toxins and the bacteria from inducing damage than inflammation could ever cause. Unfortunately, that’s just what happens. The war against germs waged by your immune system induces a whole lot of inflammation.
Continuous abnormal inflammation (like that caused by a leaky gut) changes your natural insulin levels and actions, contributing to diabetes. You eventually form, once your body starts to become insensitive to insulin. You are able to see the cycle here. The more inflammation. The more inflammation, the insulin resistance. If you add that on top of a continuously leaky gut isn’t far off.
Inflammation causing insulin resistance has been observed by Mario Kratz, Ph.D., in experiments involving mice also. Some of the mice were fat, which caused a constant inflammation. Insulin resistance was developed by the mice with this inflammation. This left the question: was it that the inflammation, or Was the fat causing the insulin resistance? To answer this question, scientists bred mice that lacked the ability to generate certain immune responses that cause inflammation. Then they proceeded to feed. What was the result? These mice didn’t have insulin resistance. What does this mean? It usually means that the insulin resistance came in the inflammation, not the fat cells themselves. This supports researcher’s claims that diabetes is contributed to by inflammation caused by a leaky gut.
Another experiment conducted on mice in 2012 took a different approach. The mice were given a drug called Tamoxifen to simulate bad gut feature, ruin their inner ecology and kill healthy bacteria. The researchers found similarities between the bowels of mice with mice and diabetes whose guts were ruined with Tamoxifen. The two groups of mice enhanced, when given insulin. To the scientists, this demonstrated that diabetes is strongly associated with gut health.
To outline, scientists do not know everything about leaky gut and how it results in diabetes, but they are starting to learn more. There is certainly more research but it is apparent that an unhealthy gut doesn’t only have an effect on digestion, but can have side effects for the health of the body.
How Would I Know if I Have a Leaky Gut?
The very first thing you might do is refer back to the indicators of a leaky gut which we already laid out for you (things such as skin rashes, joint pain, nausea, chronic fatigue, and IBS), but that might not help you as much as you’d believe. The potential symptoms includes side effects of another list of distinct ailments that have nothing to do with a leaky gut.
Some other things you can look at would be things such as:
Food Sensitivity
When radicals are continuously leaking into your blood due to a leaky gut, your body is overproducing trigger-happy antibodies, and those antibodies start to attack things which they would not normally. This causes food sensitivity, particularly to milk and gluten.
Malabsorption
As you can imagine, people with a degenerative digestive tract that’s leaking, also have difficulty absorbing nutrients. This can become evident through side-effects like fatigue.
Thyroid Issues
Leaky gut can directly contribute to chronic thyroiditis. This also leads to slow metabolism, constipation, chronic fatigue, and depression.
Tests To Identify & Diagnose Leaky Gut
It is difficult to link some other symptom straight with leaky gut due to the fact that the symptoms might be the result of almost anything else. There are a few tests that you could do in order to see whether you’ve got it. Here are some tests which could be done to identify leaky gut:
Lactulose/Mannitol test
This test involves drinking a sugary solution. A urine sample tested and is removed. If lactulose and mannitol are present, it could suggest a leaky gut.
Stool Evaluation
An expensive test that assesses for bacteria and yeast to see if your gut is infected. This evaluation isn’t likely to be covered by your insurance.
What Can I do to Prevent or Cure Leaky Gut?
We have to keep in mind the germs that reside inside your body make up a very important ecosystem that keeps your digestive tract healthy. So let us start thinking about how we could make that job easier, or at least enjoyable your intestines have a job.
Since we have mentioned several times by now, leaky gut has a lot to do with your internal germs or intestine flora. Minimize bacteria and you want to maximize the amount of bacteria that are good. This may be done through diet and exercise. It sounds simple, but there is more to it in this circumstance.
What sort of diet do you really require?
When it comes to diet, it takes more than a simple “eat healthier!” Recommendation to fight an already leaky gut. You have to imagine that your bacteria is entirely dead. To counteract your useless gut flora, you ought to think about “re-seeding” it using healthy bacteria from your diet plan. You can accomplish so by eating probiotic foods like “lassi” (a noodle drink), fermented vegetables like kimchi, or other probiotic foods such as sauerkraut, miso, or kombucha (locate a listing of probiotic foods here).
One more thing you can do is eat naturally anti-inflammatory foods to counteract the side-effects of leaky gut. Some of those foods are things like avocados, walnuts, healthy fats (such as omega-3 fatty acids), and olive oil (find out more about anti-inflammatory foods here).
Once you get started ingesting foods which will combat a leaky gut such as those mentioned previously, it is time to stop eating foods that give rise to inflammation. These foods are things such as red meat, fried foods (such as french fries — sorry!) , refined carbs (think white bread), margarine, cheese (as well as other calcium-rich dairies). These foods aren’t easy in your gut flora and tend to increase inflammation in the body.
It would also be a good idea to avoid any trans fats, and sugary foods altogether. Refined sugar contributes. In light of diabetes, anything to help improve insulin levels and a leaky gut ought to be considered.
As a review, you should replace as many processed foods as possible with organic possibilities, re-seed your gut with good bacteria by eating fermented foods, and avoid foods that give rise to inflammation or insulin resistance.
What about supplements and medications?
There are particular things that may be taken orally that affect your gut flora at a positive or a negative manner that isn’t necessarily considered a portion of your diet. So let’s talk about drugs and nutritional supplements.
You will find nutritional supplements you may take in the kind of probiotics. This certainly can help improve your digestive tract function by maintaining a healthy gut flora. Probiotics give a large dose of one type of bacteria to you for your intestines that promote good digestion, absorption, and inflammation.
On the other hand, there are lots of drugs that harm your gut flora. Taking antibiotics may be necessary when you’re sick, but don’t overuse them in pill form or perhaps in antibacterial soap. Over just bacteria are killed by antibiotics, they kill the bacteria that are good as well.
Other substances you might encounter that you may not think about are things like chlorinated water, agricultural chemicals located on non-toxic vegetables and fruits, and traces of antibiotics located in factory-farmed meat might also harm your internal flora.
In Overview: Key Takeaway
Leaky gut definitely results in, and potentially causes diabetes alongside any number of different illnesses. Thankfully, it is avoidable and curable; thus look after your intestines. If you eat healthy, exercise, and maintain your inner flora, you will be thanked by your gut personally, and you can potentially get an upper hand or even avoid it altogether.
The scope of our information is limited to chiropractic and spinal injuries and conditions. To discuss options on the subject matter, please feel free to ask Dr. Jimenez or contact us at 915-850-0900 .�
By Dr. Alex Jimenez
Additional Topics: Wellness
Overall health and wellness are essential towards maintaining the proper mental and physical balance in the body. From eating a balanced nutrition as well as exercising and participating in physical activities, to sleeping a healthy amount of time on a regular basis, following the best health and wellness tips can ultimately help maintain overall well-being. Eating plenty of fruits and vegetables can go a long way towards helping people become healthy.
When it comes to stomach discomfort during exercise, forget that old adage “no pain, no gain.” New research suggests that excessive strenuous exercise may lead to gut damage.
“The stress response of prolonged vigorous exercise shuts down gut function,” said lead author Ricardo Costa.
“The redistribution of blood flow away from the gut and towards working muscles creates gut cell injury that may lead to cell death, leaky gut, and systemic immune responses due to intestinal bacteria entering general circulation,” Costa added. He’s a senior researcher with the department of nutrition, dietetics and food at Monash University in Australia.
Researchers observed that the risk of gut injury and impaired function seems to increase along with the intensity and duration of exercise.
The problem is dubbed “exercise-induced gastrointestinal syndrome.” The researchers reviewed eight previously done studies that looked at this issue.
Two hours appears to be the threshold, the researchers said. After two hours of continuous endurance exercise when 60 percent of an individual’s maximum intensity level is reached, gut damage may occur. Costa said that examples of such exercise are running and cycling.
He said heat stress appears to be an exacerbating factor. People with a predisposition to gut diseases or disorders may be more susceptible to such exercise-related health problems, he added.
Dr. Elena Ivanina is a senior gastroenterology fellow at Lenox Hill Hospital in New York City. She wasn’t involved with this research but reviewed the study. She said that normal blood flow to the gut keeps cells oxygenated and healthy to ensure appropriate metabolism and function.
If the gut loses a significant supply of blood during exercise, it can lead to inflammation that damages the protective gut lining. With a weakened gastrointestinal (GI) immune system, toxins in the gut can leak out into the systemic circulation — the so-called “leaky gut” phenomenon, Ivanina said.
But, she underscored that exercise in moderation has been shown to have many protective benefits to the gut.
“Specifically, through exercise, patients can maintain a healthy weight and avoid the consequences of obesity,” she said. Obesity has been associated with many GI diseases, such as gallbladder disease; fatty liver disease; gastroesophageal reflux disease (GERD); and cancer of the esophagus, stomach, liver and colon. Regular moderate physical activity also lowers the risk of cardiovascular disease, type 2 diabetes and depression.
To prevent exercise-related gut problems, Costa advised maintaining hydration throughout physical activity, and possibly consuming small amounts of carbohydrates and protein before and during exercise.
Ivanina said preventive measures might help keep abdominal troubles in check. These include resting and drinking enough water. She also suggested discussing any symptoms with a doctor to ensure there is no underlying gastrointestinal disorder.
Costa recommended that people exercise within their comfort zone. If you have stomach or abdominal pain, “this is a sign that something is not right,” he said.
Individuals with symptoms of gut disturbances during exercise should see their doctor.
The study authors advised against taking nonsteroidal anti-inflammatory drugs — including ibuprofen (Advil, Motrin) or naproxen sodium (Aleve) — before working out.
Costa said there’s emerging evidence that a special diet — called a low FODMAP diet — leading up to heavy training and competition may reduce gut symptoms. FODMAP stands for fermentable oligosaccharides, disaccharides, monosaccharides, and polyols. FODMAPs are specific types of carbohydrates (sugars) that pull water into the intestinal tract.
The International Foundation for Functional Gastrointestinal Disorders suggests consulting a dietitian familiar with FODMAP diets. Such diets can be difficult to initiate properly on your own, the foundation says.
Costa also said there’s no clear evidence that dietary supplements — such as antioxidants, glutamine, bovine colostrum and/or probiotics — prevent or reduce exercise-associated gut disturbances.
The study results were published online recently in the journal Alimentary Pharmacology & Therapeutics.
Hippocrates, the father of modern medicine, stated all healing starts in the gut. And researchers carry on to prove him accurate as they unravel how a healthier gut microbiome plays a function in fat decline, disease prevention, and much additional. As we know, diet plays a very important function in keeping a healthier gut setting and dysbiosis, or a gut-flora imbalance, ramps up inflammation, and triggers lots of diseases like inflammatory bowel disease.
As a health practitioner of chiropractic, gut health gives insight into why my clients (in particular overweight or overweight clients) establish osteoarthritis in non-fat-bearing joints like the wrist, by pointing to a difficulty with systemic inflammation. And when my clients have an understanding of how an out-of-whack gut impacts digestion, they do not generally make the link concerning gut health and joint agony or other issues like head aches, mood swings, eczema, fat acquire, or tiredness that frequently accompany agony.
Gut issues can trigger agony.
How does this perform? To start with, consider that truth that your gut maintains a reliable barrier concerning your digestive tract and your inside setting, enabling important vitamins to go by when preserving out anything else. Retaining the integrity of the gut is a a person-cell-thick barrier that varieties a limited junction, which keeps out foreign invaders like bacteria, poisons, and big undigested foods particles. When these limited junctions crack down, that barrier will become infected and porous bacteria, poisons, and undigested foods particles start off slipping by. We connect with these foreign invaders antigens, or foreign substances that trigger an immune response. A double whammy ensues: You are not finding optimal vitamins when foreign invaders barge by, a problem termed intestinal permeability or leaky gut.
This link has anything to do with inflammation.
Your immune program responds with antibodies, which assault and ruin these antigens. When an antibody binds with an antigen, an immune advanced happens. Persistent leaky gut ramps up these immune complexes they flow into all-around your entire body and deposit into several tissues and organs including�you guessed it�skeletal muscle tissues and joints, creating additional inflammation. Leaky gut also contributes to autoimmune conditions, or immune responses towards unique tissues that develop destruction and decline of functionality. When that takes place in your joints, inflammation makes agony, inflammation, and stiffness. When multifactorial, researchers link leaky gut with rheumatoid arthritis as bacterial merchandise slip by your gut lining and deposit in your joints, creating an immune reaction.
You can lessen agony by healing the gut.
When my clients recover their leaky gut, they lastly set out the fireplace that feeds inflammation. That healing calms their immune program, reverses autoimmune conditions like rheumatoid arthritis, and decreases agony. And you can do this in a natural way without the need of medicine or surgical treatment. Further than concentrating on a entire-food items diet that gets rid of foods intolerances, I�ve located these 7 tactics to improve gut health to reverse agony:
1. Stage up your fiber.
Studies display that enough dietary fiber could possibly be your greatest technique to keep a healthier microbiome. Amid its benefits, fiber aids pull poisons from your gut for elimination.
2. Take in additional anti-inflammatory food items.
Omega-three fatty acids have anti-inflammatory qualities and aid alleviate agony. If wild-caught fish isn�t aspect of your diet, just take a large-high quality fish oil nutritional supplement with about three,000 milligrams of EPA and DHA.
three. Repopulate smartly.
Probiotics aid re-set up a balanced gut microbiome. Fermented food items like coconut yogurt, kefir, and sauerkraut are great sources of probiotics, but if you do not on a regular basis consume them, appear for a professional multistrain probiotic nutritional supplement with billions of microorganisms.
4. Get enough vitamin D.
Scientists link vitamin D deficiencies with several issues like inflammation, leaky gut, and autoimmune conditions like rheumatoid arthritis and chronic agony. Request your health practitioner for a twenty five-hydroxy vitamin D take a look at and perform with him or her to attain and keep optimal ranges.
5. Ditch the gluten.
If you have joint agony or other sorts of agony, gluten�s gotta go. Gliadin is the protein located in wheat, rye, and barley lots of men and women are delicate to or that leads to an outright autoimmune reaction. Your immune program sees gluten as the enemy and will unleash weapons to assault it, triggering inflammation in your gut, joints, and other regions of the entire body.
6. Avoid GMOs.
Eradicating genetically modified food items (GMOs) will become very important for healing your leaky gut considering the fact that GMOs destruction your digestive tract and may possibly be a person of the leads to of your leaky gut in the initial place.
7. Nix nightshades.
Colourful bell peppers, tomatoes, potatoes, and eggplants supply vitamins and phytonutrients, but they can be a difficulty for clients with leaky gut, autoimmune disease, or osteoarthritis. Nightshades incorporate glycoalkyloids, which can develop gut issues.
Chronic fatigue syndrome, a baffling disorder that affects an estimated 1 million Americans, has been strongly linked to imbalances in gut bacteria in a new study from Columbia University’s Mailman School of Public Health.
The researchers found abnormal levels of specific gut bacteria are found in people with the condition — formally known as myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS), according to the study published in the journal Microbiome.
The findings offer new hope for an effective new way to diagnose and treat ME/CFS, a complex, sometimes-debilitating disorder that can interfere with activities of daily living.
Symptoms include extreme fatigue after exertion, muscle and joint pain, cognitive dysfunction, sleep disturbances, and orthostatic intolerance (light-headedness, dizziness, or fainting when standing upright).
Up to 90 percent of ME/CFS patients also have irritable bowel syndrome IBS, past research has shown. But the Columbia University study is among the first to disentangle microbiome imbalances in individuals with ME/CFS and IBS.
“Individuals with ME/CFS have a distinct mix of gut bacteria and related metabolic disturbances that may influence the severity of their disease,” says co-lead investigator Dr. Dorottya Nagy-Szakal.
The findings suggest sufferers may be able to ease their symptoms by incorporating certain probiotics — healthy bacteria — in their diets, to balance their gut bacteria.
To reach their conclusions, the researchers tracked 50 ME/CFS patients and 50 others without the condition. They tested subjects’ fecal samples for bacterial species, and blood samples for immune molecules.
The study’s key findings show that:
Levels of distinct intestinal bacterial species —Faecalibacterium, Roseburia, Dorea, Coprococcus, Clostridium, Ruminococcus, Coprobacillus — are strongly associated with ME/CFS.
The abundance of these species appears to be predictive of a ME/CFS diagnosis.
An abundance of Alistipes and low levels of Faecalibacterium are the top biomarkers of ME/CFS with IBS. Increased Bacteroides abundance and decreased Bacteroides vulgatus are the top biomarkers of ME/CFS without IBS.
The researchers also noted the severity of patients’ symptoms — such as pain and fatigue — correlated with the abundance of distinct bacterial types.
“Our analysis suggests that we may be able to subtype patients with ME/CFS by analyzing their fecal microbiome,” says co-lead investigator Dr. Brent L. Williams, Ph.D. “Subtyping may provide clues to understanding differences in manifestations of disease.”
The study also points toward a possible mechanism behind the development of ME/CFS.
“ME/CFS may involve a breakdown in the bidirectional communication between the brain and the gut mediated by bacteria, their metabolites, and the molecules they influence,” explains senior author Dr. W. Ian Lipkin.
“By identifying the specific bacteria involved, we are one step closer to more accurate diagnosis and targeted therapies.”
So far, researchers have not identified the cause of ME/CFS. Nor are there any standard diagnostic lab tests or federally-approved treatments for the condition. For reasons that are unclear, women are two to four more times likely than men to have ME/CFS.
Because MD/CFS is so variable, treatment focuses on individual symptom control. Conventional approaches include prescription medications to treat anxiety, depression, and insomnia; graded exercise, physical therapy, and psychological counseling including cognitive-behavioral therapy (CBT).
Adjunctive therapies to help manage pain and fatigue include:
Acupuncture.
Biofeedback.
Deep breathing exercises.
Hypnosis.
Massage.
Meditation.
Muscle relaxation techniques.
Yoga or tai chi.
Preliminary but inconclusive research suggests that some natural remedies may be helpful for ME/CFS, according to the Mayo Clinic. These include:
Magnesium injected into the muscles of people with low red blood cell magnesium.
A combination supplement containing fish oil and evening primrose oil.
Melatonin.
Nicotinamide.
Adenine dinucleotide hydrate (NADH).
Coenzyme Q10.
Propionyl-L-carnitine.
D-ribose.
Although the new Columbia University study suggests that probiotic supplements may be helpful for ME/CFS, more research is needed, experts say.
A 2009 study of 39 ME/CFS patients, however, showed that the Lactobacillus casei strain Shirota (LcS) was associated with significantly reduced anxiety symptoms compared to placebo.
Breastfeeding has long been linked to a variety of health benefits in babies, and a new study suggests that bacteria transferred from mothers to their nursing infants might be at least partly responsible.
Researchers focused on what’s known as the microbiome, or all of the bacteria, viruses and fungi that live in and on the body. They tested 107 mother-baby pairs for organisms on women’s breasts and in their milk, and they also examined babies’ stool as a way of determining what types of organisms were in the infant gut microbiome.
While they found distinct types of bacteria in milk, breast tissue and infant stool, researchers also found infants’ gut microbial communities matched the bacteria in their mothers’ milk and on their mothers’ skin much more than it resembled samples from other women in the study.
That suggests each mother’s milk was a major contributor to her own infant’s gut microbiome.
“We were able to show that there are bacteria in milk and that these bacteria could be traced to bacteria in infant stools,” said senior study author Dr. Grace Aldrovandi, chief of the division of infectious diseases at Mattel Children’s Hospital at the University of California, Los Angeles.
“This supports the hypothesis that milk microbes are a mechanism by which breastfeeding provides benefit,” Aldrovandi said by email.
Pediatricians recommend that mothers exclusively breastfeed infants until at least 6 months of age because it is tied to reduced risk for babies of ear and respiratory infections, sudden infant death syndrome, allergies, childhood obesity and diabetes.
Mothers may benefit too, with longer periods of breastfeeding linked to lower risks of depression, bone deterioration and certain cancers.
Based on lab tests of bacteria found in milk, on skin and in stool in the current study, researchers estimated that babies who got at least 75 percent of their nutrition from breast milk during the first month of life received about 28 percent of their gut bacteria from their mother’s milk. These babies also got about 10 percent of their gut bacteria from mothers’ skin and 62 percent from sources researchers didn’t determine.
The more babies nursed, the more their gut bacterial community changed to resemble what was found in their mother’s milk.
And in babies who got more of their nutrition exclusively from breastfeeding, microbial communities were slightly more diverse overall and different microbes predominated compared to babies who breastfed less.
One limitation of the study is that researchers didn’t assess the origins of the breast milk bacteria or other bacterial communities from the mother that might have contributed to the infant gut microbiome, the authors note. Nor did they assess any effects on the babies’ health based on differences in their microbiomes.
Still, the results build on previous research suggesting that the infant gut microbiome is different for breast-fed and formula-fed babies, said Dr. Alexander Khoruts, a researcher at the University of Minnesota in Minneapolis who wasn’t involved in the study.
“We’ve always assumed that most of these microbes come from the mother,” Khoruts said by email. “They found that breastfeeding is the major source of microbial transfer during the early months of life, and I think the study provides supportive evidence for the current recommendations of exclusive breastfeeding for the first six months and continued breastfeeding to 12 months.”
Many factors can influence the infant gut microbiome, including breastfeeding, whether babies arrived by vaginal or surgical delivery and antibiotic use, noted Jose Clemente, a researcher in the genetics and genomic sciences at the Icahn School of Medicine at Mount Sinai in New York.
“The beneficial effects of breastfeeding are well known, and this study provides further evidence by demonstrating that probiotic bacteria found in breast milk can be transferred to the infant,” Clemente, who wasn’t involved in the study, said by email. “Every little bit helps, so even some amount of breast milk can be a source of beneficial bacteria for babies.”
Intense physiological stress can change the composition of our gut microbiota
Imbalances in the gut arelinked to diabetes, obesity and some cancers
Findings raise concerns for endurance athletes and military personnel
The study is the first to investigate gut bateria during military training
Long periods of intense exercise can change the composition of your gut bacteria, a new study has found.
The research looked at soldiers taking part in an intensive training programme and found that pro-longed exercise caused the protective barrier in their guts to become permeable.
In other words, the prolonged exertion triggered �leaky guy syndrome� � a condition that could let harmful substances leak into the bloodstream.
With our gut health and overall health believed to be strongly linked, intense physiological stress could therefore raise the risks of many types of illnesses.
The new research is the first to investigate the response of gut microbiome � the term for the population of microbes in the intestine � during military training.
It provides a stark warning for endurance athletes and military personnel.
The study suggests physical stress can increase intestinal permeability, which can raise the risk of inflammation and illness
Most of us are aware that the bacteria in our gut play an important role in digestion. Furthermore, they are known to aid the production of certain vitamins � such as vitamins B and K � and play a key role in immune function.
But increasingly, research is emerging showing how poor gut health is linked to conditions ranging from irritable bowel syndrome, diabetes, high blood pressure, depression, obesity, childhood asthma, to colitis and colon cancer.
The study is the first to investigate the response of gut microbiome � the term for the population of microbes in the intestine � during military training.
It looked at a group of 73 Norwegian Army soldiers taking part in a military-style cross country skiing training programme.
Recent research suggests our gut bacteria holds the key to improving our health � and may be the key to tackling obesity
The group skied 31 miles (51 km) while carrying 99-pound (45 kg) packs, across four days.
Before and after the training exercise, researchers collected blood and stool samples from the soldiers.
It was found that the microbiome and metabolites � the substance formed in or necessary for metabolism � in the soldiers� blood and stool altered �significantly� by the end of the aggressive training period.
Furthermore, sucralose excretion in their urine samples rose considerably, indicating an increase in intestinal permeability (IP).
Scientists know that healthy intestines have a semi-permeable barrier, which acts as a defense to keep bacteria and other harmful substances out, while allowing healthy nutrients into the bloodstream.
It is thought that physical stress can increase IP, increasing the risk of inflammation, illness and symptoms such as diarrhoea.
The findings may spell bad news for endurance athletes and military personnel
The researchers wrote: �Intestinal microbiota appear to be one influencing factor in the gut�s response to physical stress.
�Our findings suggest that the intestinal microbiota may be one mediator of IP responses to severe physiologic stress, and that targeting the microbiota before stress exposure may be one strategy for maintaining IP.�
The study was published ahead of print in the American Journal of Physiology � Gastrointestinal and Liver Physiology.
MICROBIOME: DOES IT CONTROL EVERYTHING?
Researchers now estimate that a typical human body is made up of about 30 trillion human cells and 39 trillion bacteria.
These are key in harvesting energy from our food, regulating our immune function, and keeping the lining of our gut healthy.
Interest in, and knowledge about, the microbiota has recently exploded as we now recognise just how essential they are to our health.
A healthy, balanced microbiome helps us break down foods, protects us from infection, trains our immune system and manufactures vitamins, such as K and B12.
It also sends signals to our brain that can affect mood, anxiety and appetite.
Imbalances in the gut are increasingly being linked to a range of conditions. Last year, scientists at California Institute of Technology found the first ever link between the gut and Parkinson�s symptoms.
The composition of our gut microbiota is partly determined by our genes but can also be influenced by lifestyle factors such as our diet, alcohol intake and exercise, as well as medications.
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