Back Clinic Research Studies. Dr. Alex Jimenez has compiled study and research projects that are pertinent to the science and art of chiropractic medicine. The subsets can be classified as following: Case Study, Case Series, Cross-Sectional, Cohort, Case-Control, and Randomized Control Trials. Each subset of study profiles has its merits and scientific significance.
It is our intention to bring clarity to present-day research models. We will discuss and present significant clinical interpretations that may serve outpatients well. Great care in selecting appropriate and well-documented models has been enforced in our blog. We gladly will listen and heed comments on the discussed subject matters presented. For answers to any questions you may have please call Dr. Jimenez at 915-850-0900
Painful symptoms may influence a person’s everyday physical actions. Patients with neck pain and spine pain caused by an assortment of health problems, including automobile accidents, have found tremendous relief from their symptoms with Dr. Alex Jimenez. Chiropractic care is a safe and effective, alternative treatment option which concentrates on the diagnosis, treatment, and prevention of injuries and/or conditions related to the musculoskeletal and nervous systems. Dr. Alex Jimenez has enhanced the quality of life of many patients by carefully restoring the integrity of their spine and improving debilitating symptoms. Patients highly recommend Dr. Alex Jimenez since the non-surgical selection for neck pain and spine pain, among other health problems, in El Paso, Tx.
Non-Surgical Care
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We are blessed to present to you�El Paso�s Premier Wellness & Injury Care Clinic.
As El Paso�s Chiropractic Rehabilitation Clinic & Integrated Medicine Center,�we passionately are focused on treating patients after frustrating injuries and chronic pain syndromes. We focus on improving your ability through flexibility, mobility and agility programs tailored for all age groups and disabilities.
We want you to live a life filled with more energy, positive attitude, better sleep, less pain, proper body weight and educated on how to maintain this way of life.
I assure you, I will only accept the best for you�
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James Hill came to Injury Medical & Chiropractic Clinic after his daughter Madison suffered a sports injury. Through a variety of chiropractic treatment methods and techniques, Dr. Jimenez helped Madison find relief from her ankle pain so she could return-to-play as soon as possible. Madison regained the confidence she needed with Dr. Jimenez�and is recovering properly. James Hill and Madison highly recommend Dr. Alex Jimenez as the non-surgical choice for sports injuries. Chiropractic treatment is an�alternative treatment that works through rehabilitation procedures.
Sports Injury Chiropractic
We are blessed to present to you�El Paso�s Premier Wellness & Injury Care Clinic.
As El Paso�s Chiropractic Rehabilitation Clinic & Integrated Medicine Center,�we passionately are focused on treating patients after frustrating injuries and chronic pain syndromes. We focus on improving your ability through flexibility, mobility and agility programs tailored for all age groups and disabilities.
We want you to live a life filled with more energy, positive attitude, better sleep, less pain, proper body weight and educated on how to maintain this way of life.
I assure you, I will only accept the best for you�
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Automobile injury accidents are common health problems which can affect an individual’s overall health and wellness. For several patients, automobile accident injuries can tremendously restrict their capacity to participate in their regular physical tasks. Dr. Alex Jimenez is a doctor of chiropractic in El Paso, TX who specializes in the identification, treatment, and prevention of a variety of health problems associated with the musculoskeletal and nervous system, such as auto accident injuries. Chiropractic care is another treatment option which uses spinal adjustments and manual manipulations to thoroughly fix any misalignment of the backbone, or subluxation, which might be causing debilitating symptoms. Dr. Alex Jimenez is the non-surgical choice for car accident injuries, among other health problems.
Chiropractic Rehabilitation
We are blessed to present to you�El Paso�s Premier Wellness & Injury Care Clinic.
As El Paso�s Chiropractic Rehabilitation Clinic & Integrated Medicine Center,�we passionately are focused on treating patients after frustrating injuries and chronic pain syndromes. We focus on improving your ability through flexibility, mobility and agility programs tailored for all age groups and disabilities.
We want you to live a life filled with more energy, positive attitude, better sleep, less pain, proper body weight and educated on how to maintain this way of life.
I assure you, I will only accept the best for you�
If you have enjoyed this video and we have helped you in any way, please feel free to subscribe and recommend�us.
Chronic pain caused by accidents and/or aggravated conditions can often be one of the primary reasons for depression in patients. When painful symptoms induce patients to struggle with their everyday physical activities, their mental health can be tremendously influenced. Chiropractic care utilizes spinal adjustments and manual manipulations which could help restore the initial integrity of the backbone. Patients describe how chiropractic care has helped them recover their well-being and they highly recommend Dr. Alex Jimenez, doctor of chiropractic, as the non-surgical choice for chronic pain and depression, one of a variety of other common health issues.
Chiropractic Relief
We are blessed to present to you�El Paso�s Premier Wellness & Injury Care Clinic.
As El Paso�s Chiropractic Rehabilitation Clinic & Integrated Medicine Center,�we passionately are focused on treating patients after frustrating injuries and chronic pain syndromes. We focus on improving your ability through flexibility, mobility and agility programs tailored for all age groups and disabilities.
We want you to live a life that is fulfilled with more energy, positive attitude, better sleep, less pain, proper body weight and educated on how to maintain this way of life. I have made a life of taking care of every one of my patients.
I assure you, I will only accept the best for you�
If you have enjoyed this video and we have helped you in any way, please feel free to subscribe and recommend�us.
Damaris Foreman suffered from migraines before she received chiropractic care with the chiropractor, Dr. Alex Jimenez. After various treatment approaches were unable to provide Damaris Foreman with the migraine pain relief she needed, she was skeptical at first about chiropractic care. However, following the migraine pain relief she found with Dr. Alex Jimenez, Damaris Foreman highly recommends chiropractic care. She emphasizes how much Dr. Jimenez has helped her and how much she has learned about her health issue. Damaris Foreman states that Dr. Alex Jimenez has provided her with the best treatment approach she has ever received for her migraines. Dr. Jimenez is the non-surgical choice for a variety of injuries and conditions, including headaches and migraines.�
Chiropractic Therapy
We are blessed to present to you�El Paso�s Premier Wellness & Injury Care Clinic.
As El Paso�s Chiropractic Rehabilitation Clinic & Integrated Medicine Center,�we passionately are focused on treating patients after frustrating injuries and chronic pain syndromes. We focus on improving your ability through flexibility, mobility and agility programs tailored for all age groups and disabilities.
We want you to live a life that is fulfilled with more energy, positive attitude, better sleep, less pain, proper body weight and educated on how to maintain this way of life. I have made a life of taking care of every one of my patients.
I assure you, I will only accept the best for you�
If you have enjoyed this video and we have helped you in any way, please feel free to subscribe and recommend�us.
After a slip-and-fall accident,�Aracely Norte was limited�in her ability to work, that affected her quality of life. Due to chronic pain, Aracely had difficulty engaging in regular, everyday responsibilities. After hearing about El Paso, TX. Chiropractor, Dr. Alex Jimenez, from her lawyer, Aracely found relief from her chronic pain. Aracely describes how Dr. Jimenez cared for her injuries while he educated her about her health issues and the treatment he provided her with. Aracely highly recommends Dr. Jimenez as the non-surgical choice for chronic pain. Chronic pain is a common issue which can occur due to a variety of reasons, including injuries and underlying conditions, however, chiropractic care can help eliminate chronic pain symptoms.�
Chiropractic Rehab
We are blessed to present to you�El Paso�s Premier Wellness & Injury Care Clinic.
As El Paso�s Chiropractic Rehabilitation Clinic & Integrated Medicine Center,�we passionately are focused on treating patients after frustrating injuries and chronic pain syndromes. We focus on improving your ability through flexibility, mobility and agility programs tailored for all age groups and disabilities.
We want you to live a life that is fulfilled with more energy, positive attitude, better sleep, less pain, proper body weight and educated on how to maintain this way of life. I have made a life of taking care of every one of my patients.
I assure you, I will only accept the best for you�
If you have enjoyed this video and we have helped you in any way, please feel free to subscribe and recommend�us.
Multiple sclerosis, or MS, is a chronic disease of the central nervous system, or CNS. While the etiology of the disease remains unknown, research studies have found that environmental factors, such as nutrition, may have an impact on the occurrence and development of MS. Other research studies specifically analyzed the association between certain dietary factors in multiple sclerosis, such as fat, dairy and meat consumption. Multiple sclerosis, or MS, epidemiology suggests that dairy is primarily involved in the clinical expression of the disease. The purpose of the following article is to show the effects of cow’s milk allergy in multiple sclerosis patients.
Abstract
Background: Exposure to some environmental agent such as different nutrition and contact with allergens may have a role in developing multiple sclerosis (MS). The present study was aimed to evaluate the cow’s milk allergy (CMA) in MS patients compared to healthy controls.
Materials and Methods: Between March 2012 and July 2012, 48 MS patients were selected and compared with 48 healthy subjectsto assess the frequency of CMA in MS patients compared to healthy control. Cow’s milk specific immunoglobin E (IgE) was determined by Immuno CAP. Sex and the frequency of CMA were compared between study groups by Chi-square test.
Results: Total of 96 subjects were assessed (22% male and 78% female). The mean age of the study subjects was 30.8 � 6.6 years. Mean age of case and control groups was 30.7 (�6.9) versus 30.9 � 6.3, respectively (P value = 0.83). There were no detection of cow’s milk specific IgE in serum of MS patients and healthy subjects.
Conclusion: There was no difference between MS and healthy subjects regarding CMA.
Keywords:Allergy, cow’s milk, multiple sclerosis
Introduction
Multiple sclerosis (MS) is achronic inflammatory demyelinating disease of the central nervous system (CNS)[1] and it is one among the common causes of neurological disability in young adults especially, women.[2] Autoimmune processes due to defects in regulatory T cells and failing of suppression auto-reactive CD4+ and CD8+ cells is suggested have a role in pathogenesis of disease.[3]
Although, the etiology of MS is unknown, there are some evidences for convolution with both genetic and environmental influences on susceptibility. Relative vitamin D deficiency,[4,5] Epstein-Barr virus,[6] and smoking[7] are among environmental factors that all have been associated with increased susceptibility to MS. Nutrition is another environmental factor thatpossibly involved in pathogenesis of MS.[8] Furthermore, dietary factors are frequently mentioned as a possible cause, there are very few clinical trials based on specific diets or dietary supplements in MS and there is no evidence in this respect.[9] Higher intake of different food compounds were considered to be associated with increased risk of MS[9] such as sweets,[10] alcohol,[11,12,13] smoked meat products,[10] coffee, tea,[11] and yet, none of these data were approved by subsequent studies. In 1991, in a study, it has been reported that dietary factors or food allergies may be among major causes of MS beginning and progression.[14] In the other hand, vitamin D has been implicated as being a risk-factor in MS,[15,16,17] and it is reported that decreased levels of 25-hydroxyvitamin D are associated with an increased risk to develop MS.[18] Furthermore, the totality of evidence for a protective role of vitamin D in MS has been supposed strong enough by some to warrant recommending vitamin D supplementation to people with MS.[19] Cow’s milk allergy (CMA) has an indirect potential to cause 25-hydroxyvitamin D deficiency from affected individuals tend to avoid dairy of cow’s milk products.[20]
In infancy, cow’s milkis the most frequently encountered dietary allergen, and the incidence of CMA varies with age.[21] In infants and adult the reported prevalence of CMA varies between studies; however, it is clear that CMA is common allergy in early childhood, with a prevalence of 2-6%,[22] and decreases with age.[23]
It is believed that exposure to some environmental agent that occurs before puberty may begin autoimmune process and pre-dispose a genetically susceptible person to develop MS later on. Based on this fact, the hypothesis of a link between milk consumption and MS has been considered since many years ago and epidemiological studies were carried out to support this correlation.[24]
It is considered that improvement of immunological defenses effect on treatment of MS patients, therefore, detection of allergens and elimination of them from the diet could decrease disability of patients,
The present study was aimed to evaluate the CMA in MS patients compared to healthy controls.
Materials and Methods
Between March 2012 and July 2012, 48 MS patients (referring to MS clinic of the referral universityhospital in Isfahan) were selected and compared with 48 healthy subjects (among patients� companions and acquaintances as control group) to assess the association between CMA and MS. MS patients were diagnosed to definitely develop MS according to the McDonald Criteria.[25] Patients were eligible if they had not received corticosteroids during last month and immunosuppressants over the last 3 months. This study was investigated and approved by the ethics committee at the Isfahan University of Medical Sciences and all subjects were explained about the aim and the purposes of the study and written informed consent was obtained from all of them.
Controls were matched with the patients in regard to age and gender. To determine the allergen-specific immunoglobin E (IgE) of cow’s milk, blood samples were taken from both groups of subjects and serum samples were transferred to the laboratory of Immunology.
ImmunoCAP (Phadia, Uppsala, Sweden) was used for allergen-specific IgE antibody in the serum of the subjects to be obtained. This technique is approved by Food and Drug Administration in US and has high-sensitivity and many good features[26,27,28] also in Iran are applicable only in the Asthma and Allergy Research Institute, Tehran University of Medical Sciences. Moreover, specific IgE antibody against cow’s milk was determined and applying statistical techniques, calculations were performed and results were extracted.
Data are presented as means � standard deviation or number (%) as appropriate. Independent sample t-test was used to compare age between groups. Furthermore, sex and the frequency of CMA were compared between study groups by Chi-square test. All analysis was carried out by the Statistical Package for the Social Sciences (SPSS)-20 and statistical significance was accepted at P < 0.05.
Multiple sclerosis, or MS, is a multifactorial, inflammatory, and neurodegenerative disease of the central nervous system which has been demonstrated to be closely associated with environmental factors like nutrition. Recent research studies on the role of diet in MS provided evidence that certain dietary factors, such as the consumption of dairy products like cow’s milk, influence multiple sclerosis incidence, disease course and symptomatology. According to these research studies, particular types of proteins found in cow’s milk have been demonstrated to stimulate the immune system of people with MS.
Dr. Alex Jimenez D.C., C.C.S.T.
Results
A total of 96 subjects were assessed and results of all blood samples were analyzed. On the total subjects, 22% were male and 78% were female and the mean age of the study subjects was 30.8 � 6.6 years. Table 1 shows the comparison of age, gender, and the frequency of CMA between study groups. As shown mean age of in case and control groups was similar and there was no statistical significant difference between groups (30.7 � 6.9 vs. 30.9 � 6.3 respectively, P value = 0.83). Of 22 male subjects, 50% were MS patients and 50% were controls. There was no significant difference between study groups in regard to gender composition. Results of CAP technique to determined allergen-specific IgE antibody against cow’s milk in MS patients and healthy subjects showed that, there was no any positive CMA in these subjects and there was no difference between MS patients and healthy subjects.
Discussion
Since many years ago the effect of diet such as fat intake in MS has been postulated.[29] There is a higher extent consumption of saturated fat, dairy products, and cornflakes (cereals) and a decrease in the consumption of unsaturated fat in area with high prevalence of MS.[29]
Though, the findings of these studieswere not confirmed by a large number of case-control studies, epidemiological studies have proposed the association between MS prevalence and animal fat consumption.[11,12,13] Because MS is believed to have an autoimmune basis, many factors such as dietary can induce autoimmunity and myelin breakdown by molecular mimicry.[30]
It seems that molecular mimicry may disrupt immunological self-tolerance to CNS myelin antigens in genetically susceptible individuals. CMA is one of the most common food allergen in infancy. It seems that immune system identifies some of proteins of milk as harmful and makes IgE antibodies to neutralize it. IgE antibodies recognize these proteins in next contact and signal the immune system to release some chemicals.[31]
Therefore, cow’s milk as a dietary protein has potential molecular mimicry with myelin autoantigens and may induce autoimmune process, so consumption of milk in MS patients may have a possible role in progression or relapse of disease. Furthermore, as mentioned earlier, vitamin D has been implicated as being a risk-factor in MS patients[18] and CMA transmits nutritional implications as affected individuals have a tendency to evade dairy products and have been shown to be lacking in 25-hydroxyvitamin D.[20]
Measurement of specific IgE confirmed an IgE-mediated sensitivity to cow’s milk and is a prognostic marker for persistence of CMA.[31]
In present study, we evaluated the cow’s milk IgE to find allergy to milk in MS patients compare to control as a marker of persistence CMA. The result of study did not show positive CMA in MS group and no difference between MS patients and control subjects.
Our findings was similar to result of Ramagopalan et al. study.[32] Ramagopalan, in a population-based cohort in 2010, investigated whether or not childhood CMA influences the subsequent risk to develop MS. They collected data by telephone interview from mothers of 6638 MS index cases and 2509 spouse controls in Canada and compared the frequency of CMA between index cases and controls and could not find any significant differences. Therefore, author concluded that childhood CMA does not appear to be a risk-factor for MS.
Another study suggested that factors of liquid cow milk influence on the clinical appearance of MS.[25]
Although, medical interest in the influence of diet on the rate and severity of MS disease were carried out,[33] as our best knowledge, there are few studies in food allergens and MS, so further studies are suggested to be carried out to investigate food allergens, in a large number of MS patients and healthy individuals based on individuals recall, then positive responses assess using advanced technique and results compared between MS patients and healthy subjects.
In summary, findings of our study investigated that there is no difference between subjects developing MS and healthy subjects regarding CMA and we could not find any association between CMA and MS.
Conclusion
This study evaluated the frequency distribution of cow milk allergy in MS patients compared to healthy controls. Although, there was no significant difference between two groups, the small sample size of MS patients may effect on the association of this hypothesis.
Footnotes
Source of Support: Nil
Conflict of Interest: None declared.
Multiple sclerosis, or MS, is a chronic disease of the central nervous system, or CNS which is believed to be associated with environmental factors, such as nutrition. Research studies analyzing the association between certain dietary factors in multiple sclerosis demonstrated that dairy is primarily involved in the clinical expression of multiple sclerosis. The purpose of the article above was to show the effects of cow’s milk allergy in multiple sclerosis patients. According to the research study, dairy may have some effect on the prevalence of MS, although further research studies are still required to further conclude these findings. Information referenced from the National Center for Biotechnology Information (NCBI). The scope of our information is limited to chiropractic and spinal health issues. To discuss the subject matter, please feel free to ask Dr. Jimenez or contact us at�915-850-0900�.
Curated by Dr. Alex Jimenez
Additional Topic Discussion:�Acute Back Pain
Back pain�is one of the most prevalent causes of disability and missed days at work worldwide. Back pain attributes to the second most common reason for doctor office visits, outnumbered only by upper-respiratory infections. Approximately 80 percent of the population will experience back pain at least once throughout their life. The spine is a complex structure made up of bones, joints, ligaments, and muscles, among other soft tissues. Injuries and/or aggravated conditions, such as�herniated discs, can eventually lead to symptoms of back pain. Sports injuries or automobile accident injuries are often the most frequent cause of back pain, however, sometimes the simplest of movements can have painful results. Fortunately, alternative treatment options, such as chiropractic care, can help ease back pain through the use of spinal adjustments and manual manipulations, ultimately improving pain relief.
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