Dr. Alex Jimenez Discusses Microbiome and Methylation
Research studies have demonstrated that our microbiome can help regulate our DNA methylation. The human microbiome is considered to be a counterpart to the human genome. In current research studies, the methylation of intestinal epithelial cells was determined to be considerably abnormal in germ-free mouse models when compared with conventional controls. This research study also demonstrated that bacteria introduced through fecal transplants considerably increased CpG methylation.
Moreover, research studies have determined that gut microbes may also produce butyrate, which can potently prevent the development of histone deacetylase, ultimately affecting the function of DNA methylation. Researchers have discussed that these outcome measures suggest our microbiome may play a fundamental role in host epigenetic regulation, beyond digestive health.
Specific types of bacteria may also cause different effects on DNA methylation. In one human pilot research study, increased levels of the bacterial phylum Firmicutes, compared to the bacterial phylum Bacteroidetes, were associated with the increased methylation of 568 genes as well as the decreased methylation of 245 genes (P=0.05). The affected genes were associated with a variety of health issues, including inflammation, cardiovascular disease, and cancer. Previous research studies in humans have also identified various ratios of the bacterial phylum Firmicutes and the bacterial phylum Bacteroidetes in overweight and obese individuals.
Gut Microbiota and Nutrient Status
Our gut microbiota can also affect our nutrient status and this may also indirectly affect our or DNA methylation. The majority of Lactobacillus species are in vitro consumers of folate with the exception of L. plantarum strains which can produce folate in the presence of para-aminobenzoic acid, or PABA. Many Bifidobacteria species, including strains of B. bifidum and B. infantis, can also produce folate, along with B. breve, B. longum, B. adolescentis, and B. pseudocatenulatum. Many of these species also produce folate in both its THF and 5mTHF forms, with B. adolescentis producing the highest levels of methylated folate.
In vivo, the administration of B. adolescentis, referred to as MB 227 and MB 239, and B. pseudocatenulatum, referred to as MB 116, increased serum folate levels in folate-deficient rats and the co-administration of prebiotic fructans increased serum folate levels further in folate-deficient rats. While human folate absorption generally occurs in the small intestine, it can also occur in the colon. By way of instance, the administration of B. longum in hemodialysis patients decreased serum homocysteine levels the same as serum folate levels increased in folate-deficient through the administration of a variety of bacteria in the gastrointestinal tract.
Furthermore, abnormal populations of bacteria in the small intestine can prevent normal nutrient absorption and appetite signaling, ultimately affecting DNA methylation. An abnormal microbiome may also cause inflammation which, as we have previously discussed, can also affect methylation. A healthy microbiome can ultimately be achieved through proper nutrition and lifestyle habits. Smoothies and juices, such as those described below, can also help improve DNA methylation as well as promote a healthy microbiome.
The human microbiota is made up of 10 to 100 trillion symbiotic microbial cells, most of these which primarily consist of gut bacteria. The role of our microbiome is fundamental towards our overall health and wellness, especially when it comes to DNA methylation activity and status, according to research studies. The human microbiota is important for a variety of bodily functions and recent research studies have demonstrated that an abnormal microbiome can tremendously affect methylation, a chemical process which affects the function of genes as well as gene expression and promotes several essential functions.
Dr. Alex Jimenez D.C., C.C.S.T. Insight
Smoothies and Juices for Methylation Support
While many healthcare professionals can recommend nutritional guidelines and lifestyle modifications to improve methylation support, there are several options you can try yourself at home. As described above, methylation support supplementation should be determined by a healthcare professional. Smoothies and juices are a fast and easy way to include all the necessary nutrients you need for methylation support without any side-effects. The smoothies and juices below are part of the Methylation Diet Food Plan.
Sea Green Smoothie Servings: 1 Cook time: 5-10 minutes � 1/2 cup cantaloupe, cubed � 1/2 banana � 1 handful of kale or spinach � 1 handful of Swiss chard � 1/4 avocado � 2 teaspoons spirulina powder � 1 cup water � 3 or more ice cubes Blend all ingredients in a high-speed blender until completely smooth and enjoy!
Berry Bliss Smoothie Servings: 1 Cook time: 5-10 minutes � 1/2 cup blueberries (fresh or frozen, preferably wild) � 1 medium carrot, roughly chopped � 1 tablespoon ground flaxseed or chia seed � 1 tablespoons almonds � Water (to desired consistency) � Ice cubes (optional, may omit if using frozen blueberries) Blend all ingredients in a high-speed blender until smooth and creamy. Best served immediately!
Sweet and Spicy Juice Servings: 1 Cook time: 5-10 minutes � 1 cup honeydew melons � 3 cups spinach, rinsed � 3 cups Swiss chard, rinsed � 1 bunch cilantro (leaves and stems), rinsed � 1-inch knob of ginger, rinsed, peeled and chopped � 2-3 knobs whole turmeric root (optional), rinsed, peeled and chopped Juice all ingredients in a high-quality juicer. Best served immediately!
Ginger Greens Juice Servings: 1 Cook time: 5-10 minutes � 1 cup pineapple cubes � 1 apple, sliced � 1-inch knob of ginger, rinsed, peeled and chopped � 3 cups kale, rinsed and roughly chopped or ripped � 5 cups Swiss chard, rinsed and roughly chopped or ripped Juice all ingredients in a high-quality juicer. Best served immediately!
Zesty Beet Juice Servings: 1 Cook time: 5-10 minutes � 1 grapefruit, peeled and sliced � 1 apple, washed and sliced � 1 whole beet, and leaves if you have them, washed and sliced � 1-inch knob of ginger, rinsed, peeled and chopped Juice all ingredients in a high-quality juicer. Best served immediately!
Protein Power Smoothie Serving: 1 Cook time: 5 minutes � 1 scoop protein powder � 1 tablespoon ground flaxseed � 1/2 banana � 1 kiwi, peeled � 1/2 teaspoon cinnamon � Pinch of cardamom � Non-dairy milk or water, enough to achieve desired consistency Blend all ingredients in a high-powered blender until completely smooth. Best served immediately!
ProLon� Fasting Mimicking Diet
Balanced methylation support can be achieved through proper nutrition. The ProLon� fasting mimicking diet offers a 5-day meal program which has been individually packed and labeled to serve the foods you need for the FMD in precise quantities and combinations. The meal program is made up of ready-to-eat or easy-to-prepare, plant-based foods, including bars, soups, snacks, supplements, a drink concentrate, and teas. The products are scientifically formulated and great tasting. Before starting the ProLon� fasting mimicking diet, 5-day meal program, please make sure to talk to a healthcare professional to find out if the FMD is right for you. The ProLon� fasting mimicking diet can help promote methylation support, among a variety of other healthy benefits.
Many doctors and functional medicine practitioners may suggest evaluating a patient’s microbiome to determine their DNA methylation status. Through proper nutrition and lifestyle habits, a healthy microbiome can improve methylation. The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .
Curated by Dr. Alex Jimenez
Additional Topic Discussion: Acute Back Pain
Back pain is one of the most prevalent causes of disability and missed days at work worldwide. Back pain attributes to the second most common reason for doctor office visits, outnumbered only by upper-respiratory infections. Approximately 80 percent of the population will experience back pain at least once throughout their life. Your spine is a complex structure made up of bones, joints, ligaments, and muscles, among other soft tissues. Injuries and/or aggravated conditions, such as herniated discs, can eventually lead to symptoms of back pain. Sports injuries or automobile accident injuries are often the most frequent cause of back pain, however, sometimes the simplest of movements can have painful results. Fortunately, alternative treatment options, such as chiropractic care, can help ease back pain through the use of spinal adjustments and manual manipulations, ultimately improving pain relief.
Formulas for Methylation Support
XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly, Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
For your convenience and review of the XYMOGEN products please review the following link.*XYMOGEN-Catalog-Download
* All the above XYMOGEN policies remain strictly in force.
Doctors are always saying exercise, get fit, but don�t give us many realistic options. Going to the gym can be difficult, especially if you are short on time.
Exercising at home can be a real pain, as well. You might be limited for space, tripping over kids � and although no one talks about it, do you want your significant other watching you sweat and gasp for air as you struggle through one of those insane workouts?
They say walking is good, but if you are in a neighborhood that doesn�t have sidewalks or it is too hot outside. Just how likely are you to get up and do it? Now suppose you could get all your exercising done in 7 minutes. Would you do it? Is it even possible?
Nowhere are there heavy weights or fancy equipment, just a wall, a chair, and the person�s body weight. Say hello to high-intensity interval training- it�s about to change your world!
This 7-minute workout is the equivalent of a serious weight training session and long run but without the weights or the running. That isn�t to say it is easy though. It requires a great deal of effort.
There�s a lot packed into those 7 minutes. It provides many of the benefits that are achieved by disciplined, long term endurance training; it just skips over the long-term part.
Make no mistake though, short does not mean it is easy � or pleasant. In fact, it may be one of the longer 7 minutes of your life.
The good news is, it�s over in 7 minutes. That�s a little more than 5 but less than 10.
It�s worth it though when you look at the numerous health benefits that exercise provides. Plus, it�s great for people who are super busy and can�t seem to squeeze a workout into their schedules. Say hello to no more excuses!
The Science Behind the 7
These 12 exercises were not chosen at random. The reason it works is rooted in some pretty deep science. When you exercise for even a few minutes and are operating at or near your maximum capacity (that means you are working very hard), it causes your muscles to experience molecular changes that are much like those that occur after several hours of riding a bike or running.
Interval training takes it a step farther. You engage in incredibly intense activity, then you have a brief recovery period, then back to a high-intensity exercise. That is the basis of this workout.
Each exercise should be done for about 30 seconds with a 10 second recovery period – but there�s a twist that ups the effectiveness even more. The exercises are arranged so that they engage the large muscles in the upper body, then in the lower body.
This alternating focus on muscle groups is essential because while the lower body is working like crazy, the upper body can be catching its breath. This makes for a much more efficient workout, but it is also why the order of the exercises is critical.
The exercises are intense but are movements that just about anyone can do. Many can also be adapted for people at different fitness levels. If you are looking for a great workout that will work for you but won�t eat up a lot of your time, you just might have found it.
Dr. Alex Jimenez Explains Methylation, Nutrition & Lifestyle Habits
A variety of healthcare professionals recommend full MDL or portions of the program to their patients. Research studies report that participants have responded well to the diet plan. By way of instance, a 57-year-old male diagnosed with diffuse myalgia and arthralgia as well as a history of toxic mold exposure, who had a methyl donor intolerance and who had a baseline homocysteine of 15.7. After one month of the MDL program, his follow-up homocysteine was 11.8, which reduced his symptoms. No additional modifications were made to his diet plan. Functional medicine practitioners and doctors may utilize the MDL program in a variety of ways, including:
As a treatment for long-term methylation support
Together with folate and other supplements to improve effectiveness
As an alternative treatment option for people with methyl donor intolerance
In this article, however, we will discuss the importance of obtaining nutrients from food rather than with supplementation. The following information reviews the foundational interventions which are relevant to the Methylation Diet and Lifestyle, or MDL, program. We will also provide a collection of smoothies and juices which can help promote methylation support and effectiveness. According to healthcare professionals, nutrients from foods improve methylation support and address significant genetic SNPs.
Food-Based Nutrients
Improving methylation through non-fortified whole foods is a safe and effective treatment, as long as enough of the relevant nutrients are consumed. During a 16-week human placebo-controlled trial, an increase of 200 mcg/d folate from folate-rich foods demonstrated the same capability to increase plasma and erythrocyte folate levels as well as to lower homocysteine compared with an equal amount of supplemental folic acid or 5-mTHF as Metafolin�. Dietary folate, along with changes to lifestyle habits, can improve methylation.
There is currently no limit set for folate intake from non-fortified foods and no research studies have found side-effects from folates and other methylation nutrients from foods. But, what amount of nutrient intake is enough to optimize methylation status? This will inevitably be different for each individual based on their genetic fingerprint and environmental factors. A Cochrane systematic review, published in 2014, demonstrated that food-sourced folate could protect against the risk of cancer, specifically breast cancer, within the range of 153 � 400 mcg/d, suggesting that increased supplementation is not necessarily beneficial for the general population.
However, specific populations may have genetic or environmental factors which may need them to have higher nutrient intakes. There are a variety of nutrients involved with methylation enzymes and pathways, demonstrated as either substrates or cofactors. Table 6 below, lists these important nutrients and their dietary sources, including methionine, cysteine, taurine, DHA, zinc, magnesium, potassium, riboflavin, niacin, pyridoxine, folate, vitamin B12, betaine, choline, and sulfur. Several of these nutrients have previously been utilized as targeted supplements by many functional medicine practitioners or doctors for a wide variety of diet plans.
Depending on the genotype of the individual, nutrient intake needs can be further customized to support an individual’s potential enzyme deficiencies. Individuals with specific SNPs may benefit from increased intake of cofactor nutrients used by the associated enzyme because it has been demonstrated that increased cofactor intake can push the rate of enzymatic reactions forward. Table 7 below, lists commonly examined methylation-related genes and the nutrients that can be used to support activity and status, including MTHFR, MTR, MTRR, MAT1A, MAO, COMT, CBS, MTRR, and BHMT, as well as their cofactor nutrient support.
Nutrient Assimilation
If an individual’s needs are determined either by laboratory testing or physical exam findings, the Five-R Protocol utilized as a part of the MDL program, is outlined in Table 8 as an ideal way to improve nutrient assimilation and functional status. It can be done together with a short-term course of methylation supplementation with subsequent transition to the MDL or with the MDL from the start. Functional medicine practitioners or doctors may recommend changes to nutrition and lifestyle habits for methylation support.
Nutrient supplementation is commonly used to help promote methylation support, however, research studies have demonstrated that the best way to improve methylation activity and its overall status is through food-based nutrient intake. High doses of supplements have been known to cause side-effects but eating nutrient-rich foods provides the same if not greater benefits than supplementation. Smoothies and juices such as those listed below can promote methylation support.
Dr. Alex Jimenez D.C., C.C.S.T. Insight
Smoothies and Juices for Methylation Support
While many healthcare professionals can recommend nutritional guidelines and lifestyle modifications to improve methylation support, there are several options you can try yourself at home. As described above, methylation support supplementation should be determined by a healthcare professional. Smoothies and juices are a fast and easy way to include all the necessary nutrients you need for methylation support without any side-effects. The smoothies and juices below are part of the Methylation Diet Food Plan.
Sea Green Smoothie Servings: 1 Cook time: 5-10 minutes � 1/2 cup cantaloupe, cubed � 1/2 banana � 1 handful of kale or spinach � 1 handful of Swiss chard � 1/4 avocado � 2 teaspoons spirulina powder � 1 cup water � 3 or more ice cubes Blend all ingredients in a high-speed blender until completely smooth and enjoy!
Berry Bliss Smoothie Servings: 1 Cook time: 5-10 minutes � 1/2 cup blueberries (fresh or frozen, preferably wild) � 1 medium carrot, roughly chopped � 1 tablespoon ground flaxseed or chia seed � 1 tablespoons almonds � Water (to desired consistency) � Ice cubes (optional, may omit if using frozen blueberries) Blend all ingredients in a high-speed blender until smooth and creamy. Best served immediately!
Sweet and Spicy Juice Servings: 1 Cook time: 5-10 minutes � 1 cup honeydew melons � 3 cups spinach, rinsed � 3 cups Swiss chard, rinsed � 1 bunch cilantro (leaves and stems), rinsed � 1-inch knob of ginger, rinsed, peeled and chopped � 2-3 knobs whole turmeric root (optional), rinsed, peeled and chopped Juice all ingredients in a high-quality juicer. Best served immediately!
Ginger Greens Juice Servings: 1 Cook time: 5-10 minutes � 1 cup pineapple cubes � 1 apple, sliced � 1-inch knob of ginger, rinsed, peeled and chopped � 3 cups kale, rinsed and roughly chopped or ripped � 5 cups Swiss chard, rinsed and roughly chopped or ripped Juice all ingredients in a high-quality juicer. Best served immediately!
Zesty Beet Juice Servings: 1 Cook time: 5-10 minutes � 1 grapefruit, peeled and sliced � 1 apple, washed and sliced � 1 whole beet, and leaves if you have them, washed and sliced � 1-inch knob of ginger, rinsed, peeled and chopped Juice all ingredients in a high-quality juicer. Best served immediately!
Protein Power Smoothie Serving: 1 Cook time: 5 minutes � 1 scoop protein powder � 1 tablespoon ground flaxseed � 1/2 banana � 1 kiwi, peeled � 1/2 teaspoon cinnamon � Pinch of cardamom � Non-dairy milk or water, enough to achieve desired consistency Blend all ingredients in a high-powered blender until completely smooth. Best served immediately!
ProLon� Fasting Mimicking Diet
Balanced methylation support can be achieved through proper nutrition. The ProLon� fasting mimicking diet offers a 5-day meal program which has been individually packed and labeled to serve the foods you need for the FMD in precise quantities and combinations. The meal program is made up of ready-to-eat or easy-to-prepare, plant-based foods, including bars, soups, snacks, supplements, a drink concentrate, and teas. The products are scientifically formulated and great tasting. Before starting the ProLon� fasting mimicking diet, 5-day meal program, please make sure to talk to a healthcare professional to find out if the FMD is right for you. The ProLon� fasting mimicking diet can help promote methylation support, among a variety of other healthy benefits.
Many doctors and functional medicine practitioners may recommend higher doses of methyl donors in several patients, however, further research studies are needed to determine the proper amount of methylation supplementation. The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .
Curated by Dr. Alex Jimenez
Additional Topic Discussion: Acute Back Pain
Back pain is one of the most prevalent causes of disability and missed days at work worldwide. Back pain attributes to the second most common reason for doctor office visits, outnumbered only by upper-respiratory infections. Approximately 80 percent of the population will experience back pain at least once throughout their life. Your spine is a complex structure made up of bones, joints, ligaments, and muscles, among other soft tissues. Injuries and/or aggravated conditions, such as herniated discs, can eventually lead to symptoms of back pain. Sports injuries or automobile accident injuries are often the most frequent cause of back pain, however, sometimes the simplest of movements can have painful results. Fortunately, alternative treatment options, such as chiropractic care, can help ease back pain through the use of spinal adjustments and manual manipulations, ultimately improving pain relief.
Formulas for Methylation Support
XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly, Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
For your convenience and review of the XYMOGEN products please review the following link.*XYMOGEN-Catalog-Download
* All the above XYMOGEN policies remain strictly in force.
Most people now acknowledge just how bad sugar is. The problem is, many are not willing to give it up. The evidence is clear though, over the last three decades chronic disease like diabetes, cancer, and heart disease have grown exponentially in occurrences that correlate strongly with Americans� ever-increasing intake of sugar.
But while this may not be new information, people are still unwilling to make the changes necessary � even with the threat of poor or worsening health (and even death) hanging over their heads.
One of the problems is that it is very difficult to get away from. Pick up almost any product on your grocery store shelves and read the ingredients. Sugar is there most of the time.
It is found in most processed foods including spaghetti sauce, salad dressings, dried fruit, fruit juices, even so-called �healthy� foods like frozen quinoa blends and �diet� frozen dinners. Sugar is everywhere and people are consuming it without even realizing that they are doing so.
Contents
Sugar is Addictive
Again, this is not new information, but many people don�t realize just how addictive sugar really is. One research article compared sugar addiction to drug addiction. The authors even went so far as to say sugar is as addictive as cocaine (or more so).
There is strong evidence to support this; sugar does affect a person at the neurobiological level. It activates the brain�s reward center, similar to what drugs do. Regular exposure provokes cravings similar to drug addiction and withdrawal symptoms when it is stopped.
The real problem here is that it is 1) legal, and 2) available for anyone to purchase- even children. There is a huge push to market sugar to children through heavily sugared cereals, drinks, and snack foods.
The children want it because they saw it on TV, the parents buy it, and the children end up cognitively impaired, obese, and chronically ill. It�s time to start connecting the dots and making significant changes in not only what we eat, but what we feed our children.
But Why is Sugar so Bad?
In its pure form, right out of the sugar cane, the juice has nutritional properties. However, all of that nutrition is destroyed when it is processed and refined as sugar (even “raw,” turbinado, and other forms – it’s still sugar). It becomes something that may be edible but isn�t really food. It is just a substance with absolutely no nutritional value � but lots of potential for damage.
The moment sugar enters your bloodstream your body begins secreting insulin. Insulin is produced in the pancreas and its function is to regulate sugar in the blood, to keep it balanced. When you overwhelm your body with sugar it keeps producing more and more insulin. A diet that is high in sugar can result in insulin resistance which can lead to obesity, diabetes, high blood pressure, and other dangerous conditions.
The more sugar you consume, the harder your body has to work to process it. It gets stored in the liver, leading to a fatty, enlarged liver, high glucose levels, and even affect the function of your organs including your kidneys. If you have conditions like heart disease, diabetes, or high blood pressure, the risk of damage to your organs is increased even more.
High glucose levels have also been linked to impaired cognitive function, loss of memory, depression, and anxiety as well as an increased risk of dementia. It can cause difficulty in concentration and the inability to focus or stay on task.
The solution here is to avoid sugar or make low sugar choices. Read labels! Take the time to think about what you are putting into your body and how it will affect you. If you make a conscious effort to reduce your sugar intake, over time your body will stop craving it.
*Detox Your Body* | Detox Doctor | El Paso, TX (2019)
The ketogenic diet, also known as a low carb diet is being talked about in various circles. And while science has proven over and over about the numerous health benefits, there are still those that want to disclaim it. This guide will explain the ketogenic diet, ketones, and the many health benefits that this way of eating provides.
Contents
What are Exogenous Ketones?
In order to understand exogenous ketones, it is important to first know what ketones are. Simply put, ketones are carbon-based, organic compounds that are produced in the liver. They are used by the mitochondria within the body to generate energy and can replace glucose as a fuel source, putting the body in a state of ketosis.
Exogenous ketones are ketones that are taken into the body as nutritional supplements. Endogenous ketones are produced in the body, specifically, the liver. Exogenous ketones are not produced in the body, rather are introduced into the body through supplements.
What is a Ketogenic Diet?
A ketogenic diet is characterized by three primary markers:
Low carbohydrate
Adequate protein
High fat
It is designed to put the body into a state of ketosis which means that instead of burning carbohydrates for energy, it is forced to burn fat.
When the body consumes foods that are high in carbs, it begins to produce insulin and glucose. Glucose happens to be the path of least resistance when it comes to energy conversion and usage, so the body will opt for that route before any utilizing another energy source.
What are the Benefits of a Ketogenic Diet?
There are several significant health benefits of a ketogenic diet. It was developed to be a way of life (WOL), not just a temporary diet and this was primarily due to the health benefits it provides. In fact, ketone diets were created to help allay or improve the symptoms of certain chronic health conditions, including epilepsy. Other benefits of the ketogenic diet include:
Weight loss
Lower insulin levels and reduced blood sugar
Lower triglycerides
Effectively treats metabolic syndrome
Forces the body to burn fat
Increased HDL (�good� cholesterol) levels
Improve LDL
Prevention of certain cancers
Potential to kill certain cancer cells
Lowered blood pressure
Improve epilepsy symptoms
Help treat Parkinson�s Disease
Reverse and treat symptoms of Alzheimer�s
The weight loss occurs from a ketogenic diet is largely fat loss – particularly abdominal fat (visceral fat). It is visceral fat that increases the risk of heart disease, type 2 diabetes, and other health conditions.
A ketogenic diet helps to reduce many of the risks of some of the most debilitating and even deadly chronic health conditions that are so prevalent today. Exogenous ketones provide a powerful supplementation to the diet, improving its effectiveness.
A ketogenic diet is not a quick fix or fad diet; it is indeed a way of life. While many people do see very noticeable results quite quickly, the substantial health benefits that it provides make it worthy of a lifelong commitment. By adhering to this low carb lifestyle, you can reverse many health conditions and avoid others. In short, you will enjoy increased energy and better health for years to come.
Dr. Alex Jimenez Explains Methylation Status, Inflammation and Oxidative Stress
As previously mentioned in the past series of articles, doctors can use a variety of clinical assessments to evaluate the methylation status of their patients. Although no assessment method or technique can accurately determine a patient’s methylation activity, current assessments can provide a better understanding of methylation-related genetic polymorphisms, nutrient status, methylation-related neurotransmitters and neurotransmitter metabolites, amino acids, hormones and metabolites, oxidative stress, and detoxification load. Each of these processes and substances can help doctors and patients understand their methylation status.
Understanding Methylation Status
Various assessment methods and techniques, including measures utilized to determine DNA methylation status, are usually exclusive to research studies and are not yet readily available to doctors. Until methylation status assessments become more widely available, further diagnosis is still required to understand diseases, especially since conflicting outcome measures have been found in research studies on the various methodologies. Although methods and techniques from research studies have rapidly started to evolve, patterns of DNA methylation status in humans across cells, tissues, age, populations, environmental factors like nutrition and lifestyle modifications, as well as disease, have only just started to become more widely recognized by researchers and doctors.
It is fundamental that we focus on a variety of these indicators and that we become aware of the restrictions of our interpretations and their misunderstood factors. Plasma homocysteine, by way of instance, can decrease as methylation activity increases, but, it can also decrease when oxidative stress levels increase, regardless if methylation activity increases. However, as we�ve previously mentioned, only several SNPs have known, quantifiable alterations in enzymatic function and their overall outcome measures on methylation remain unknown. Doctors must rely on a variety of clinical assessments to evaluate the methylation status of their patients. In the following articles, we will continue to discuss methylation status assessment options available to doctors for patients.
Understanding Inflammation
Inflammation increases the production of cytokine which can alter a patient’s methylation status in a variety of ways. DNA methylation activity is also tremendously affected by inflammation-related signaling molecules. Cytokines, chemokines, free radicals, prostaglandins, growth factors, and matrix metalloproteinases, are produced during inflammation, altering epigenetic changes in DNA methylation activity. IL-1?, by way of instance, suppresses p53 expression, creating a more favorable environment for tumorigenesis. NF?B is a central transcription factor triggered by inflammation which also regulates the expression of more than 400 genes.
Moreover, it directly regulates NK?B-dependent histone demethylase which in turn regulates the fate and transdifferentiation of tumor cells. IL-6, another inflammatory signaling molecule, regulates the activity of DNMTs, microRNAs and histone methyltransferases which affect the epigenetics of p53 tumor suppressor genes by reducing expression. TNF-alpha increases in mitotically-preserved and region-specific DNA methylation activity in a way that seems to include impaired cellular differentiation and renewal. In vitro outcome measures suggest that inflammation may also promote the production of methyl radicals which trigger DNA methylation activity in normal, unmethylated tumor suppressor genes, causing gene silencing and carcinogenesis.
Inflammation can also cause a metabolic milieu that drains methylation resources, by way of instance, through the dysregulation of glucose homeostasis. Pro-inflammatory molecules can also alter insulin signaling in peripheral tissues, reducing inflammatory mediators that promote insulin signaling. Insulin dysfunction and hyperglycemia promote elevated levels of oxidative stress which triggers increased utilization of glutathione and depleted homocysteine, methionine and SAMe. Furthermore, DNA methylation patterns affecting metabolism and inflammation were identified in adipose tissue from subjects with type 2 diabetes.
Understanding Oxidative Stress
Oxidative stress is closely associated with inflammation. States of elevated, or chronic, oxidative stress can negatively alter DNA methylation through two mechanisms. First, oxidative stress increases the demand for glutathione synthesis, which pulls homocysteine towards transulfuration pathways, at the expense of methylation pathways and SAMe formation. Second, oxidative stress and increased hydroxyl radical formation can damage DNA and change the ability of DNA methyltransferase enzymes to appropriately methylate DNA. This is one of the most common causes of global DNA hypomethylation and specific areas of hypermethylation.
DNA guanine nucleotides are main regions of DNA damage caused by oxidative stress, which is why they are frequently utilized as a biomarker for DNA-level oxidative stress, or 8OHdG. Generally, guanine functions as a hydrogen bond acceptor to promote the creation of methyl binding protein, or MBP, DNA complexes. However, oxidation of guanine considerably decreases MBP binding when combined to the 5- methylcytosine nucleotide. Additionally, 5-methylcytosine, or 5-mC, may also experience oxidation or hydroxylation, forming 5-hydroxymethylcytosine, or 5-hmC, through oxidative stress. This can tremendously affect interactions with DNA-proteins that can prevent their binding affinity to MBPs, leading to potentially heritable epigenetic alterations.
The methods and techniques commonly utilized to determine DNA methylation can’t distinguish between 5-mC and 5-hmC, which may prove to be an essential distinction, especially in the brain, where most DNA hydroxymethylation can be found. There is outcome measures which demonstrate that acute psychological stress can increase DNA hydroxymethylation in the hippocampal glucocorticoid receptor gene. This epigenetic alteration can lead to the development of neuropsychiatric and neurodegenerative disorders. Aging is also associated with increases in 5-hmC in the brain which may be prevented by caloric restriction and antioxidant upregulation.
A variety of research studies have found that DNA methylation can be affected by inflammation, most commonly caused due to oxidative stress. Increasing outcome measures have also demonstrated that methylation activity may become affected in response to both nutritional and environmental influences. Alterations in DNA methylation caused by inflammation and oxidative stress can lead to problems in gene expression, increasing the potential risk of disease. Understanding the effects of inflammation due to oxidative stress is fundamental when investigating epigenetic mechanisms. DNA methylation assessments based on inflammation and oxidative stress can help patients regulate their overall health and wellness.
Dr. Alex Jimenez D.C., C.C.S.T. Insight
Smoothies and Juices for Methylation Support
While many healthcare professionals can recommend nutritional guidelines and lifestyle modifications to improve methylation support, there are several options you can try yourself at home. As described above, methylation support supplementation should be determined by a healthcare professional. Smoothies and juices are a fast and easy way to include all the necessary nutrients you need for methylation support without any side-effects. The smoothies and juices below are part of the Methylation Diet Food Plan.
Sea Green Smoothie Servings: 1 Cook time: 5-10 minutes � 1/2 cup cantaloupe, cubed � 1/2 banana � 1 handful of kale or spinach � 1 handful of Swiss chard � 1/4 avocado � 2 teaspoons spirulina powder � 1 cup water � 3 or more ice cubes Blend all ingredients in a high-speed blender until completely smooth and enjoy!
Berry Bliss Smoothie Servings: 1 Cook time: 5-10 minutes � 1/2 cup blueberries (fresh or frozen, preferably wild) � 1 medium carrot, roughly chopped � 1 tablespoon ground flaxseed or chia seed � 1 tablespoons almonds � Water (to desired consistency) � Ice cubes (optional, may omit if using frozen blueberries) Blend all ingredients in a high-speed blender until smooth and creamy. Best served immediately!
Sweet and Spicy Juice Servings: 1 Cook time: 5-10 minutes � 1 cup honeydew melons � 3 cups spinach, rinsed � 3 cups Swiss chard, rinsed � 1 bunch cilantro (leaves and stems), rinsed � 1-inch knob of ginger, rinsed, peeled and chopped � 2-3 knobs whole turmeric root (optional), rinsed, peeled and chopped Juice all ingredients in a high-quality juicer. Best served immediately!
Ginger Greens Juice Servings: 1 Cook time: 5-10 minutes � 1 cup pineapple cubes � 1 apple, sliced � 1-inch knob of ginger, rinsed, peeled and chopped � 3 cups kale, rinsed and roughly chopped or ripped � 5 cups Swiss chard, rinsed and roughly chopped or ripped Juice all ingredients in a high-quality juicer. Best served immediately!
Zesty Beet Juice Servings: 1 Cook time: 5-10 minutes � 1 grapefruit, peeled and sliced � 1 apple, washed and sliced � 1 whole beet, and leaves if you have them, washed and sliced � 1-inch knob of ginger, rinsed, peeled and chopped Juice all ingredients in a high-quality juicer. Best served immediately!
Protein Power Smoothie Serving: 1 Cook time: 5 minutes � 1 scoop protein powder � 1 tablespoon ground flaxseed � 1/2 banana � 1 kiwi, peeled � 1/2 teaspoon cinnamon � Pinch of cardamom � Non-dairy milk or water, enough to achieve desired consistency Blend all ingredients in a high-powered blender until completely smooth. Best served immediately!
ProLon� Fasting Mimicking Diet
Balanced methylation support can be achieved through proper nutrition. The ProLon� fasting mimicking diet offers a 5-day meal program which has been individually packed and labeled to serve the foods you need for the FMD in precise quantities and combinations. The meal program is made up of ready-to-eat or easy-to-prepare, plant-based foods, including bars, soups, snacks, supplements, a drink concentrate, and teas. The products are scientifically formulated and great tasting. Before starting the ProLon� fasting mimicking diet, 5-day meal program, please make sure to talk to a healthcare professional to find out if the FMD is right for you. The ProLon� fasting mimicking diet can help promote methylation support, among a variety of other healthy benefits.
Many doctors and functional medicine practitioners may recommend higher doses of methyl donors in several patients, however, further research studies are needed to determine the proper amount of methylation supplementation. The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .
Curated by Dr. Alex Jimenez
Additional Topic Discussion: Acute Back Pain
Back pain is one of the most prevalent causes of disability and missed days at work worldwide. Back pain attributes to the second most common reason for doctor office visits, outnumbered only by upper-respiratory infections. Approximately 80 percent of the population will experience back pain at least once throughout their life. Your spine is a complex structure made up of bones, joints, ligaments, and muscles, among other soft tissues. Injuries and/or aggravated conditions, such as herniated discs, can eventually lead to symptoms of back pain. Sports injuries or automobile accident injuries are often the most frequent cause of back pain, however, sometimes the simplest of movements can have painful results. Fortunately, alternative treatment options, such as chiropractic care, can help ease back pain through the use of spinal adjustments and manual manipulations, ultimately improving pain relief.
Formulas for Methylation Support
XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly, Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
For your convenience and review of the XYMOGEN products please review the following link.*XYMOGEN-Catalog-Download
* All the above XYMOGEN policies remain strictly in force.
Pinched nerves are a common complaint that can cause a wide variety of symptoms. In many cases the condition can be resolved quickly through chiropractic care; sometimes with just one session. However, chiropractic should be treated as an ongoing practice for better health and wellness.
Not only can chiropractic care help you better manage pain and resolve many health problems it can also help prevent injuries and certain conditions from developing. This often means that seeking chiropractic for a pinched nerve is a wise decision and can bring a quick resolution.
In the spine, a herniated disc can put pressure on the nerve root, causing pain and discomfort. In the wrist, it can cause a condition known as carpal tunnel syndrome.
Why is a Pinched Nerve such a Challenge?
The issue with a pinched nerve is finding the source. When a nerve is pinched, the pain and other symptoms may not be at the actual site. Instead, the pain and other sensations can travel to other parts of the body, including down the leg or through the arm. This can make it difficult to treat, but an experienced, knowledgeable chiropractor can assess the situation and treat the condition, bringing relief to the patient.
Symptoms of a Pinched Nerve?
A pinched nerve can manifest with many different symptoms, often depending on its location in the body. They may worsen while the patient is sleeping. Some of the most common symptoms include:
Pain that is aching or sharp
Lower or mid back pain
Neck pain
Shoulder pain
General spinal pain
Pain that radiates down the leg or arm
Numbness or tingling in the legs, arms, fingers, or toes
Burning sensation in the legs, arms, fingers, or toes
Muscle weakness in the legs or back
Headaches
Frequently feeling like a hand or food is �asleep�
When the nerve is not pinched for very long, it typically does not leave the patient with any permanent damage. When the pressure is relieved, normal function returns rather quickly. On the other hand, if the pressure is not relieved, it can cause permanent damage to the nerve, leading to chronic pain.
Causes of a Pinched Nerve?
A pinched nerve can have a number of causes. Wrist or rheumatoid arthritis is a common cause, but others may include:
Injury
Repetitive motion that places stress on parts of the body
Obesity
Sports activities
Certain hobbies that require repetitive motion
Treatments for a Pinched Nerve?
The first line of treatment for a pinched nerve is rest. Medications may be recommended or prescribed, such as NSAIDs and muscle relaxers, but remember every drug has side effects so make sure you talk to your medical doctor before moving forward.
Physical therapy is another common treatment. The patient is taught certain exercises that stretch and strengthen muscles around the pinched nerve so that it relieves pressure. They are also given self-management techniques that they can do at home to get relief. However, if the pinched nerve is do to a misalignment in the spine, it doesn�t matter how many exercises you do; they won�t fix the problem. In severe cases, surgery may be recommended. This is usually a last resort.
Does Chiropractic for a Pinched Nerve Really Work?
Chiropractic care is a very effective treatment for pinched nerve because it addresses the root cause and works toward fixing the problem through spinal manipulation and very specific chiropractic adjustments. By bringing the body into alignment, pressure on the nerves is relieved. This helps relieve the pain but also facilitates healing allowing the patient to return to their normal daily activities and experience less downtime.
El Paso, TX Piriformis Syndrome Chiropractic Treatment
Healthcare professionals can use several clinical assessments to examine the methylation status of their patients. But, there is not one type of assessment method or technique that can accurately show the complexity of methylation in the human body. Current assessments can help offer an understanding for methylation-related genetic polymorphisms, nutrient status, methylation-related neurotransmitters and neurotransmitter metabolites, amino acids, hormones and metabolites, oxidative stress, and detoxification load. The majority of these processes and substances can also help offer an understanding of a patient’s overall methylation status.
Contents
Understanding Methylation Status
Various assessment methods and techniques, such as measures used to determine DNA methylation status, are usually limited to research studies and are not yet available to healthcare professionals. As DNA methylation status assessments become more available, treatment is important to understand data since conflicting outcome measures have been found in research studies based on several methodologies as methylation is further examined. Furthermore, although methods and techniques, as well as research studies, are quickly evolving, patterns of DNA methylation status in humans across cells, tissues, age, populations, environmental factors such as nutrition and lifestyle modifications, and disease, are only just being recognized by a majority of healthcare professionals.
It is essential that we emphasize several of these indicators and be mindful of the limitations of our interpretations as well as their misunderstood factors. Plasma homocysteine, for example, can decrease as methylation activity increases, but, it can also decrease when oxidative stress levels increase, independently if methylation activity increases But, as we�ve previously discussed, only a few SNPs have known, quantifiable changes in enzymatic function, and even then, their overall outcome measures on methylation are unknown. Healthcare professionals must rely on a variety of clinical assessments to determine methylation health and wellness. In the following articles, we will discuss several methylation status clinical assessment options available to healthcare professionals.
Understanding Methylation Metabolites
To understand how DNA methylation status can be measured through the various assessment methods and techniques previously discussed, we must first understand how methylation metabolites influence methylation status. As demonstrated in Table 3, several laboratory-assessed metabolites are used in the assessment of methylation status. These have been recorded as follows.
Understanding Nutrient Assimilation Capability
In the previous article, we also discussed how nutrient status can depend on several factors. Although optimal nutrient status begins with the food we eat, it is through the process of digestion, absorption, transport, utilization, and metabolism of each nutrient which must function together to promote the necessary effect. Two of the most common problems occur in the process of digestion and absorption. Healthcare practitioners utilizing an MDL program may also examine and correct gastric function, pancreatic function, intestinal dysbiosis, intestinal permeability, food sensitivities, and malabsorption issues. The majority of these processes and substances can ultimately affect the absorption of essential nutrients necessary for DNA methylation status and activity.
Several methods and techniques have become widely available to healthcare professionals in order to show the DNA methylation status of patients. DNA methylation is identified by the combination of a methyl group to DNA. Healthcare professionals must first understand the good and the bad of these various methods and techniques which have become widely available to show methylation status and to allow them to make an informed choice when deciding which assessment will best suit their research study needs and the overall health and wellness of the patient.
Dr. Alex Jimenez D.C., C.C.S.T. Insight
Smoothies and Juices for Methylation Support
While many healthcare professionals can recommend nutritional guidelines and lifestyle modifications to improve methylation support, there are several options you can try yourself at home. As described above, methylation support supplementation should be determined by a healthcare professional. Smoothies and juices are a fast and easy way to include all the necessary nutrients you need for methylation support without any side-effects. The smoothies and juices below are part of the Methylation Diet Food Plan.
Sea Green Smoothie Servings: 1 Cook time: 5-10 minutes � 1/2 cup cantaloupe, cubed � 1/2 banana � 1 handful of kale or spinach � 1 handful of Swiss chard � 1/4 avocado � 2 teaspoons spirulina powder � 1 cup water � 3 or more ice cubes Blend all ingredients in a high-speed blender until completely smooth and enjoy!
Berry Bliss Smoothie Servings: 1 Cook time: 5-10 minutes � 1/2 cup blueberries (fresh or frozen, preferably wild) � 1 medium carrot, roughly chopped � 1 tablespoon ground flaxseed or chia seed � 1 tablespoons almonds � Water (to desired consistency) � Ice cubes (optional, may omit if using frozen blueberries) Blend all ingredients in a high-speed blender until smooth and creamy. Best served immediately!
Sweet and Spicy Juice Servings: 1 Cook time: 5-10 minutes � 1 cup honeydew melons � 3 cups spinach, rinsed � 3 cups Swiss chard, rinsed � 1 bunch cilantro (leaves and stems), rinsed � 1-inch knob of ginger, rinsed, peeled and chopped � 2-3 knobs whole turmeric root (optional), rinsed, peeled and chopped Juice all ingredients in a high-quality juicer. Best served immediately!
Ginger Greens Juice Servings: 1 Cook time: 5-10 minutes � 1 cup pineapple cubes � 1 apple, sliced � 1-inch knob of ginger, rinsed, peeled and chopped � 3 cups kale, rinsed and roughly chopped or ripped � 5 cups Swiss chard, rinsed and roughly chopped or ripped Juice all ingredients in a high-quality juicer. Best served immediately!
Zesty Beet Juice Servings: 1 Cook time: 5-10 minutes � 1 grapefruit, peeled and sliced � 1 apple, washed and sliced � 1 whole beet, and leaves if you have them, washed and sliced � 1-inch knob of ginger, rinsed, peeled and chopped Juice all ingredients in a high-quality juicer. Best served immediately!
Protein Power Smoothie Serving: 1 Cook time: 5 minutes � 1 scoop protein powder � 1 tablespoon ground flaxseed � 1/2 banana � 1 kiwi, peeled � 1/2 teaspoon cinnamon � Pinch of cardamom � Non-dairy milk or water, enough to achieve desired consistency Blend all ingredients in a high-powered blender until completely smooth. Best served immediately!
ProLon� Fasting Mimicking Diet
Balanced methylation support can be achieved through proper nutrition. The ProLon� fasting mimicking diet offers a 5-day meal program which has been individually packed and labeled to serve the foods you need for the FMD in precise quantities and combinations. The meal program is made up of ready-to-eat or easy-to-prepare, plant-based foods, including bars, soups, snacks, supplements, a drink concentrate, and teas. The products are scientifically formulated and great tasting. Before starting the ProLon� fasting mimicking diet, 5-day meal program, please make sure to talk to a healthcare professional to find out if the FMD is right for you. The ProLon� fasting mimicking diet can help promote methylation support, among a variety of other healthy benefits.
Many doctors and functional medicine practitioners may recommend higher doses of methyl donors in several patients, however, further research studies are needed to determine the proper amount of methylation supplementation. The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .
Curated by Dr. Alex Jimenez
Additional Topic Discussion: Acute Back Pain
Back pain is one of the most prevalent causes of disability and missed days at work worldwide. Back pain attributes to the second most common reason for doctor office visits, outnumbered only by upper-respiratory infections. Approximately 80 percent of the population will experience back pain at least once throughout their life. Your spine is a complex structure made up of bones, joints, ligaments, and muscles, among other soft tissues. Injuries and/or aggravated conditions, such as herniated discs, can eventually lead to symptoms of back pain. Sports injuries or automobile accident injuries are often the most frequent cause of back pain, however, sometimes the simplest of movements can have painful results. Fortunately, alternative treatment options, such as chiropractic care, can help ease back pain through the use of spinal adjustments and manual manipulations, ultimately improving pain relief.
Formulas for Methylation Support
XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly, Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
For your convenience and review of the XYMOGEN products please review the following link.*XYMOGEN-Catalog-Download
* All the above XYMOGEN policies remain strictly in force.
Research shows that back pain is a common complaint for teachers. When you factor in the mental stress as well as the physical demands, it is easy to see how they could have problems with aches and pains. Chiropractic care offers a proactive approach to health care and overall wellness to keep teachers pain free.
Teachers go through a lot in a day. They spend hours on their feet. They bend, stoop, and lift, hunching over students� desks helping them and carrying heavy books. They sit at a desk, grading papers. It�s no wonder so many of our educators complain of neck and back pain! The good news is, regular chiropractic care can help alleviate those symptoms so that teachers can keep doing what they do best � sculpting young minds.
Contents
Why Teachers should Seek Chiropractic Care
When you are juggling home, family, and career, it is easy to put your health on the back burner. You may start out ignoring that twinge of pain in your lower back, or those headaches that you get now and then. But if left untreated, these problems can worsen.
That occasional back pain could turn into a full-time ordeal, affecting your arms, legs, even your feet. The occasional headaches could steadily increase in intensity and frequency until it seems you can�t go a day without one.
When your body is bombarded with pain it affects every aspect of your life. Even low-level pain that is constant can lower your performance on the job and at home. It can cause irritability, difficulty concentrating, and fatigue. Your students suffer; your family suffers. It is really worth it?
Chiropractic care is a proactive approach to better health both mentally and physically. It will help you stay on top of your game so that you function better in the classroom as well as at home.
When you feel better you will have more energy to do the things you enjoy. Even once a week or once every two weeks in a chiropractor�s office can make a world of difference in how you feel and how you function.
What Chiropractic won�t do for Teachers
Chiropractic is a natural approach to health care. It provides patients with a non-invasive, medication-free way to manage their pain. The teacher who seeks out chiropractic care will not be prescribed mind-numbing medications that upset the stomach and inhibit your performance in the classroom.
It won�t prescribe invasive procedures that require time off work and out of the class while you recuperate. Medical doctors often just treat just the symptoms without every addressing the root of the problem. This is an almost sure-fire guarantee that your problems will return because they were never resolved.
Chiropractic seeks to find the cause of the problem so that the pain can be managed, not just temporarily relieved.
How Chiropractic Benefits Teachers
When you visit a chiropractor, he or she will do much more than just adjust your neck and back. They may discuss with you the activities you enjoy, what your schedule is like, and how you spend your day.
While they will realign your spine and bring your body back into alignment, they will also help you in other areas as well. This translates to fewer sick days, less pain, and increased effectiveness in the classroom.
Chiropractic provides a whole-body approach to wellness. It sees the patient, treating the underlying causes, not just the symptoms.
Your chiropractor may offer nutrition and dietary advice, advising you to lose weight, eliminate certain foods from your diet, or add certain foods. They may recommend lifestyle changes like quitting smoking or incorporating exercise into your daily routine.
You may be given supplements that support your immunity, joints, or overall health. By treating the whole patient, chiropractic is more effective and will greatly improve the patient�s quality of life.
As mentioned in our previous article, doctors can use various clinical assessments to evaluate the methylation status of their patients. While no assessment method or technique can accurately demonstrate methylation, current assessments provide an understanding of methylation-related genetic polymorphisms, nutrient status, methylation-related neurotransmitters and neurotransmitter metabolites, amino acids, hormones and metabolites, oxidative stress, and detoxification load. Each of these processes and substances can ultimately help doctors and patients understand their methylation status and what this means for their overall health and wellness.
Contents
Understanding Methylation Status
Several assessment methods and techniques, such as measures utilized to determine DNA methylation status, are typically restricted to research studies and are not yet available to doctors. Until methylation status assessments become more widely available, further healthcare is still required to understand data, especially since conflicting outcome measures have been demonstrated in research studies based on various types of methodologies. Although methods and techniques, including research studies, have quickly started to evolve, patterns of DNA methylation status in humans across cells, tissues, age, populations, environmental factors such as nutrition and lifestyle modifications, and disease, have only just started to become more characterized by researchers and doctors.
It is fundamental that we focus on various of these indicators and that we become mindful of the limitations of our interpretations and their misunderstood factors. Plasma homocysteine, for example, can decrease as methylation activity increases, but, it can also decrease when oxidative stress levels increase, regardless of methylation activity improvements. However, as we�ve previously mentioned, only several SNPs have known, quantifiable changes in enzymatic function and their overall outcome measures on methylation remain unknown. Doctors must rely on various clinical assessments to evaluate the methylation status of their patients. In the following articles, we will continue to discuss methylation status assessment options available to many healthcare professionals.
Understanding Nutrient Status
Folate and vitamin B12 are some of the most well-known nutrients which play a primary role in methylation activity, but, there are a variety of other nutrients associated with methylation enzymes and pathways, either as substrates or cofactors, as demonstrated in Figure 4 above. There are various methods or techniques available for the assessment of nutrient status, as demonstrated in Table 2 below, including laboratory analytes and physical exam findings. Dietary intake assessment, through the evaluation of diet diaries, also provides nutrient intake date which can be a useful tool for evaluating nutrient inputs and as a basis for adjustment of nutrient intake. Many doctors routinely utilize nutrient intake evaluations together with laboratory and physical functional status assessments.
Research studies have demonstrated that DNA methylation can be affected by nutrient status. Increasing evidence has also found that methylation may change in response to both nutritional and environmental influences. Alterations in DNA methylation caused by nutrient status can lead to problems in gene expression, increasing the potential risk of disease. Nutrient status is fundamental when investigating epigenetic mechanisms. Understanding how important DNA methylation assessments based on nutrient status are can help patients regulate their overall health and wellness.
Dr. Alex Jimenez D.C., C.C.S.T. Insight
Smoothies and Juices for Methylation Support
While many healthcare professionals can recommend nutritional guidelines and lifestyle modifications to improve methylation support, there are several options you can try yourself at home. As described above, methylation support supplementation should be determined by a healthcare professional. Smoothies and juices are a fast and easy way to include all the necessary nutrients you need for methylation support without any side-effects. The smoothies and juices below are part of the Methylation Diet Food Plan.
Sea Green Smoothie Servings: 1 Cook time: 5-10 minutes � 1/2 cup cantaloupe, cubed � 1/2 banana � 1 handful of kale or spinach � 1 handful of Swiss chard � 1/4 avocado � 2 teaspoons spirulina powder � 1 cup water � 3 or more ice cubes Blend all ingredients in a high-speed blender until completely smooth and enjoy!
Berry Bliss Smoothie Servings: 1 Cook time: 5-10 minutes � 1/2 cup blueberries (fresh or frozen, preferably wild) � 1 medium carrot, roughly chopped � 1 tablespoon ground flaxseed or chia seed � 1 tablespoons almonds � Water (to desired consistency) � Ice cubes (optional, may omit if using frozen blueberries) Blend all ingredients in a high-speed blender until smooth and creamy. Best served immediately!
Sweet and Spicy Juice Servings: 1 Cook time: 5-10 minutes � 1 cup honeydew melons � 3 cups spinach, rinsed � 3 cups Swiss chard, rinsed � 1 bunch cilantro (leaves and stems), rinsed � 1-inch knob of ginger, rinsed, peeled and chopped � 2-3 knobs whole turmeric root (optional), rinsed, peeled and chopped Juice all ingredients in a high-quality juicer. Best served immediately!
Ginger Greens Juice Servings: 1 Cook time: 5-10 minutes � 1 cup pineapple cubes � 1 apple, sliced � 1-inch knob of ginger, rinsed, peeled and chopped � 3 cups kale, rinsed and roughly chopped or ripped � 5 cups Swiss chard, rinsed and roughly chopped or ripped Juice all ingredients in a high-quality juicer. Best served immediately!
Zesty Beet Juice Servings: 1 Cook time: 5-10 minutes � 1 grapefruit, peeled and sliced � 1 apple, washed and sliced � 1 whole beet, and leaves if you have them, washed and sliced � 1-inch knob of ginger, rinsed, peeled and chopped Juice all ingredients in a high-quality juicer. Best served immediately!
Protein Power Smoothie Serving: 1 Cook time: 5 minutes � 1 scoop protein powder � 1 tablespoon ground flaxseed � 1/2 banana � 1 kiwi, peeled � 1/2 teaspoon cinnamon � Pinch of cardamom � Non-dairy milk or water, enough to achieve desired consistency Blend all ingredients in a high-powered blender until completely smooth. Best served immediately!
ProLon� Fasting Mimicking Diet
Balanced methylation support can be achieved through proper nutrition. The ProLon� fasting mimicking diet offers a 5-day meal program which has been individually packed and labeled to serve the foods you need for the FMD in precise quantities and combinations. The meal program is made up of ready-to-eat or easy-to-prepare, plant-based foods, including bars, soups, snacks, supplements, a drink concentrate, and teas. The products are scientifically formulated and great tasting. Before starting the ProLon� fasting mimicking diet, 5-day meal program, please make sure to talk to a healthcare professional to find out if the FMD is right for you. The ProLon� fasting mimicking diet can help promote methylation support, among a variety of other healthy benefits.
Many doctors and functional medicine practitioners may recommend higher doses of methyl donors in several patients, however, further research studies are needed to determine the proper amount of methylation supplementation. The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .
Curated by Dr. Alex Jimenez
Additional Topic Discussion: Acute Back Pain
Back pain is one of the most prevalent causes of disability and missed days at work worldwide. Back pain attributes to the second most common reason for doctor office visits, outnumbered only by upper-respiratory infections. Approximately 80 percent of the population will experience back pain at least once throughout their life. Your spine is a complex structure made up of bones, joints, ligaments, and muscles, among other soft tissues. Injuries and/or aggravated conditions, such as herniated discs, can eventually lead to symptoms of back pain. Sports injuries or automobile accident injuries are often the most frequent cause of back pain, however, sometimes the simplest of movements can have painful results. Fortunately, alternative treatment options, such as chiropractic care, can help ease back pain through the use of spinal adjustments and manual manipulations, ultimately improving pain relief.
Formulas for Methylation Support
XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly, Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
For your convenience and review of the XYMOGEN products please review the following link.*XYMOGEN-Catalog-Download
* All the above XYMOGEN policies remain strictly in force.
IFM's Find A Practitioner tool is the largest referral network in Functional Medicine, created to help patients locate Functional Medicine practitioners anywhere in the world. IFM Certified Practitioners are listed first in the search results, given their extensive education in Functional Medicine
