Can nutritional epigenetics influence how we age and our longevity? El Paso, Tx. Dr. Jimenez presents data on how nutrition can influence longevity and how we age.
Longevity or our length of life is dictated by complex factors which include our genetic blueprint, age, health, and environment. This includes nutrition.
Gene-nutrient interactions are, partly responsible for regulating metabolic processes that begin and develop conditions like obesity, metabolic syndrome, cardiovascular disease, and cancer.
A mechanism of nutrient-gene interaction is the epigenetic involvement of inherited patterns of changes, that are maintained by other mechanisms in DNA, Fig. 1a
Although still not fully proven but on the right track was that the availability of folate improved the regeneration of the adult central nervous system after injury through an epigenetic mechanism.
Epigenetic Aging
During the last couple of years, we witnessed a remarkable increase in the number of studies addressing the relationship between epigenetic alterations and aging. Still in its infancy, and still focusing mainly on brain aging, this research clearly indicated that epigenetic mechanisms are not only responsible, in part, for the aging process but they are also dynamically related with memory formation and maintenance.
Penner MR, Roth TL, Barnes CA, Sweatt JD. An epigenetic hypothesis of aging-related cognitive dysfunction. Front Aging Neurosci 2010; 2:9.
The manipulation of the epigenome for memory improvement became possible through changes in histone acetylation.
The Link: Nutrition & Longevity
Research to complete the chain of nutrition to epigenetic changes to how we age is still ongoing.
Present knowledge of the epigenetic roles in nutrition having to do with longevity/aging relies on the structure of three components:
Nutritionally guided epigenetic modification
Age-related epigenetic changes
Comprehensive knowledge of both of these components
The first two are being developed quickly, but the third is the most demanding in terms of design, time, allocation, and cost. This takes more time. But technology/humanity is moving along at a quick pace, as well, because at the end of the day we all want to be healthy.
Therefore, Nutritional intervention, when applied at critical periods (e.g., embryonic and fetal development) is having a profound effect as to how the epigenome gets shaped.
When considering the beginning of chronic disease/s, being able to fight disease/s with food sounds like a win-win. If epigenetic/genomic nutrition can help in figuring out what we need to beat disease/s, then let’s go!
Family In Kitchen Making Morning Breakfast Together
Methyl donors, such as folate, vitamin B12, methionine, betaine or trimethylglycine, and choline, are fundamental for a variety of biochemical pathways which occur within a cell. Understanding how the human body utilizes methyl donors as well as what does methylation do in the human body can help people achieve overall health and wellness. Dr. Alex Jimenez, chiropractor, explains the essential functions of methylation on the cardiovascular, neurological, reproductive, and detoxification systems, among others.
How the Human Body Utilizes Methyl Donors
Cell division, DNA and RNA synthesis. The metabolism of folate is essential for both DNA and RNA synthesis because it is also frequently associated with the biosynthesis of purine nucleotides and thymidylate. Methyl donor deficiency can increase the risk for cytosine deamination into uracil which can elevate DNA strand breaks, fragmentation, apoptosis, and carcinogenesis.
Early CNS development. Folate deficiencies associated with genetic and environmental factors can increase the risk of neural tube defects. According to research studies, however, methylation can help improve early CNS development. National folic acid food fortification programs have been demonstrated to be successful at decreasing the risk of this condition in newborns.
Gene expression. DNA methylation is a fundamental epigenetic process which regulates gene expression. DNA methyltransferase, or DNMT, enzymes are in charge of attaching a methyl group to cytosine bases in CpG dinucleotides. Mammals introduce approximately 80 percent of CpG dinucleotides for gene expression. Elevated levels of methylation in gene promoter regions can generally cause repression. Methylation can either promote or repress expression. Research studies suggest that hypermethylation, or the increase in the methylation of cytosine and adenosine residues in DNA, is associated with the increased risk of cancer and other health issues.
Post-transcription modification. Methylation of post-transcription RNA and microRNA can help regulate microRNA translation and protein synthesis. Abnormal RNA methylation activity has been associated with a wide variety of health issues.
Immune cell differentiation. Methylation regulates the development of immune cells, including T cells and Th2 cytokine regulation.
Neurotransmitter biosynthesis and metabolism. Methylation through SAMe is an essential process in the metabolism and synthesis of biogenic amine neurotransmitters, such as dopamine, norepinephrine, epinephrine, and serotonin. Additionally, methylation is necessary for acetylcholine biosynthesis. Methylation can also regenerate tetrahydrobiopterin, a co-factor in biosynthetic pathways.
Histamine clearance. One biosynthetic pathway for histamine metabolism occurs through histamine N- methyltransferase, which needs the methyl donor SAMe. Low SAMe or altered enzyme activity can lead to an increase in histamine and clinical symptoms.
Detoxification. Together with glucuronidation, sulfuration, and acetylation, methylation is an essential pathway for the biotransformation of xenobiotics within phase II detoxification. Poor methylation activity can reduce the human body�s ability to detoxify, which can lead to toxicity-related health issues. DNA methylation also regulates Nrf2 signaling, known as the “master regulator of antioxidant defense�, a fundamental mechanism that regulates numerous phase II detoxification enzymes.
Hormone biotransformation. Methylation can help clear as well as regulate estrogens through COMT. If this process is interrupted, estrogen metabolites can increase the risk of oxidative DNA damage. Methylation is important because it can help support safe estrogen clearance, regulation, and even detoxification in patients with estrogen dominance or estrogen-receptor positive cancers.
Cellular energy metabolism. Methylation plays a fundamental role in mitochondrial or cellular energy metabolism through the biosynthesis of CoQ10, carnitine, and ATP. Cellular or mitochondrial energy metabolism can promote overall health and wellness.
Phospholipid synthesis. Methylation also plays an essential role in phospholipid synthesis. SAMe is required for the biosynthesis of phosphatidylcholine, a primary component in the cellular membrane as well as a precursor for acetylcholine, among others.
Myelination of peripheral nerves. Concentrations of SAMe deficiencies in the cerebrospinal fluids have been demonstrated to cause demyelination. DNA methylation can ultimately help improve and maintain the myelination of the peripheral nerves.
Methylation is one of the most fundamental metabolic functions of the human body and it ultimately depends on the correct function of a variety of proteins and enzymes. Methylation is the transfer of a methyl group into proteins, amino acids, enzymes, and DNA to regulate cell energy, genetic expression, and detoxification, among other essential processes. Poor methylation activity can cause a variety of health issues, including chronic inflammation, cardiovascular disease, and cancer, among other health issues. Understanding what does methylation do in the human body can help significantly improve overall health and wellness.
Dr. Alex Jimenez D.C., C.C.S.T. Insight
Smoothies and Juices for Methylation Support
While many healthcare professionals can recommend nutritional guidelines and lifestyle modifications, there are several alternative treatment options you can try for yourself at home. As described above, however, supplementation for methylation support should be correctly determined by a healthcare professional. Smoothies and juices are a fast and easy way to include all the necessary nutrients you need for methylation support in a single serving. The smoothies and juices below are part of the Methylation Diet Food Plan.
Sea Green Smoothie Servings: 1 Cook time: 5-10 minutes � 1/2 cup cantaloupe, cubed � 1/2 banana � 1 handful of kale or spinach � 1 handful of Swiss chard � 1/4 avocado � 2 teaspoons spirulina powder � 1 cup water � 3 or more ice cubes Blend all ingredients in a high-speed blender until completely smooth and enjoy!
Berry Bliss Smoothie Servings: 1 Cook time: 5-10 minutes � 1/2 cup blueberries (fresh or frozen, preferably wild) � 1 medium carrot, roughly chopped � 1 tablespoon ground flaxseed or chia seed � 1 tablespoons almonds � Water (to desired consistency) � Ice cubes (optional, may omit if using frozen blueberries) Blend all ingredients in a high-speed blender until smooth and creamy. Best served immediately!
Sweet and Spicy Juice Servings: 1 Cook time: 5-10 minutes � 1 cup honeydew melons � 3 cups spinach, rinsed � 3 cups Swiss chard, rinsed � 1 bunch cilantro (leaves and stems), rinsed � 1-inch knob of ginger, rinsed, peeled and chopped � 2-3 knobs whole turmeric root (optional), rinsed, peeled and chopped Juice all ingredients in a high-quality juicer. Best served immediately!
Ginger Greens Juice Servings: 1 Cook time: 5-10 minutes � 1 cup pineapple cubes � 1 apple, sliced � 1-inch knob of ginger, rinsed, peeled and chopped � 3 cups kale, rinsed and roughly chopped or ripped � 5 cups Swiss chard, rinsed and roughly chopped or ripped Juice all ingredients in a high-quality juicer. Best served immediately!
Zesty Beet Juice Servings: 1 Cook time: 5-10 minutes � 1 grapefruit, peeled and sliced � 1 apple, washed and sliced � 1 whole beet, and leaves if you have them, washed and sliced � 1-inch knob of ginger, rinsed, peeled and chopped Juice all ingredients in a high-quality juicer. Best served immediately!
Protein Power Smoothie Serving: 1 Cook time: 5 minutes � 1 scoop protein powder � 1 tablespoon ground flaxseed � 1/2 banana � 1 kiwi, peeled � 1/2 teaspoon cinnamon � Pinch of cardamom � Non-dairy milk or water, enough to achieve desired consistency Blend all ingredients in a high-powered blender until completely smooth. Best served immediately!
ProLon� Fasting Mimicking Diet
alanced methylation support can be achieved through proper nutrition. The ProLon� fasting mimicking diet offers a 5-day meal program which has been individually packed and labeled to serve the foods you need for the FMD in precise quantities and combinations. The meal program is made up of ready-to-eat or easy-to-prepare, plant-based foods, including bars, soups, snacks, supplements, a drink concentrate, and teas. The products are scientifically formulated and great tasting. Before starting the ProLon� fasting mimicking diet, 5-day meal program, please make sure to talk to a healthcare professional to find out if the FMD is right for you. The ProLon� fasting mimicking diet can help promote methylation support, among a variety of other healthy benefits.
Many doctors and functional medicine practitioners may recommend higher doses of methyl donors in several patients, however, further research studies are needed to determine the proper amount of methylation supplementation. The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .
Curated by Dr. Alex Jimenez
Additional Topic Discussion: Acute Back Pain
Back pain is one of the most prevalent causes of disability and missed days at work worldwide. Back pain attributes to the second most common reason for doctor office visits, outnumbered only by upper-respiratory infections. Approximately 80 percent of the population will experience back pain at least once throughout their life. Your spine is a complex structure made up of bones, joints, ligaments, and muscles, among other soft tissues. Injuries and/or aggravated conditions, such as herniated discs, can eventually lead to symptoms of back pain. Sports injuries or automobile accident injuries are often the most frequent cause of back pain, however, sometimes the simplest of movements can have painful results. Fortunately, alternative treatment options, such as chiropractic care, can help ease back pain through the use of spinal adjustments and manual manipulations, ultimately improving pain relief.
Formulas for Methylation Support
XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly, Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
For your convenience and review of the XYMOGEN products please review the following link.*XYMOGEN-Catalog-Download
* All the above XYMOGEN policies remain strictly in force.
Frozen shoulder syndrome is one common condition that affects the joint, limiting mobility and causing pain. When something goes wrong, it can dramatically impact a person�s quality of life. The shoulder bears the brunt of a lot of work even in day to day activity. The joint itself is quite complex with a wide range of motion, and that ability can become compromised due to overuse, injury, or age. The goal of the chiropractor is to keep the shoulder moving naturally and ensuring that it is a pain-free. Chiropractic is an effective treatment that helps patients regain range of motion and decrease or eliminate their pain.
What is frozen shoulder?
Frozen shoulder, or adhesive capsulitis, is characterized by pain, stiffness, and limited range of motion of the shoulder joint. It can occur as a result of overuse or after an injury, but can also be caused by diabetes or other diseases or even stroke.
It happens when the tissues that surround the joint become stiff, and scar tissue begins to form in the area. Shoulder movements become painful and difficult. It typically has a gradual onset, then goes away just as slowly. It can take a year or longer for the condition to subside.
What are the symptoms of frozen shoulder?
There are three stages of frozen shoulder and from onset to resolution. It develops gradually and subsides just as slowly with each stage lasting several months.
Stage 1 � Freezing Stage � The shoulder experiences pain during movement and the
Stage 2 � Frozen Stage � The shoulder is stiffer, but the pain may begin to decrease. However, using it becomes increasingly difficult.
Stage 3 � Thawing Stage � The shoulder begins to �loosen� and the range of motion starts to return.
Some patients may experience worsening pain at night which can lead to sleep problems.
What causes frozen shoulder?
Frozen shoulder often develops when the patient ceases regular use of the joint due to injury, pain, or a chronic health condition. There is no single cause of frozen shoulder; it can be caused by any problem involving the shoulder that prevents the patient from maintaining a full range of motion.
It can also happen when the capsule that encases the connective tissue of the shoulder becomes thick and tight. The movement of the shoulder joint is restricted, impacting its ability to move.
People who are 40 and older tend to be more at risk for frozen shoulder, and it occurs more often in women.
Patients who have had prolonged mobility of the shoulder or their shoulder has been completely immobilized are also at risk. These mobility issues may result from conditions including:
Broken Arm
Surgery recovery
Rotator cuff injury
Stroke
Certain diseases can also place patients in the high-risk category for frozen shoulder. Some disorders that may increase that risk includes:
Cardiovascular disease
Diabetes
Parkinson�s disease
Underactive thyroid
Tuberculosis
Overactive thyroid
How can chiropractic help frozen shoulder?
The primary treatment for frozen shoulder involves pain management and preserving the shoulder�s range of motion. Over the counter pain, relievers like NSAIDs and aspirin are often the first line of treatment. Physical therapy may also be used.
In situations where the symptoms persist, more aggressive treatment may be necessary. Doctors may recommend invasive remedies such as surgery and steroid injections.
However, chiropractic can treat the condition from onset through resolution. Even in instances where the symptoms persist, chiropractic can still be very effective. It can be as effective as more aggressive measures without drugs or invasive procedures. Regular chiropractic care can help return range of motion to the shoulder and return the patient�s quality of life.
How does epigenetic and personalized nutrition contribute to optimal health?
Most of us know about unhealthy food how it affects our bodies. They
Slow Down Metabolism
Add Weight
Clog and harden arteries etc.
But now there are foods and food elements that can help us in a way and comes from a place we might not of thought of, and that is our DNA.
Nutriepigenomics examines connections between diet and biomarkers that can be attached or removed from our DNA. This turns our genes on or off.
New studies are showing that certain foods or supplements can adjust the expression of our genes, which can influence our health.
Nutritional genomics is revolutionizing both clinical and public health nutritional practices:
Diet, exercise, and environmental exposure are all elements that have shown a role in switching genes on and off through epigenetics. Adjusting lifestyle factors can control the potential to reduce disease and have a positive impact on our health.
Health professionals from all over are beginning to incorporate epigenetics into their practice aiming to provide more specialized and individualized treatment plans.
�Layering information such as diet, lifestyle, environmental factors, family history, symptoms, and diagnoses along with epigenetics can help guide someone to a state of optimized health,� said Kristy Hall, MS, RNCP, ROHP, a board certified functional nutritionist and founder of Living Well Nutrition who uses epigenetic testing, nutrition counseling, and a multifaceted approach to better provide for her clients.
The upper DNA molecule differs from the lower DNA molecule at a single base-pair location (a C/A polymorphism)
Nutritional genetics or nutrigenetics involves the identification, classification, and characterization of human genetic variation that modifies nutrient metabolism/ utilization and food tolerances Fig1.
IOM. Nutrigenomics and beyond: Informing the future. Washington, DC: The National Academies Press; 2007.
Application: Genetic & Epigenetics
Nutrients, for example, pharmaceuticals, are powerful effectors of genome expression and stability, and these gene-nutrient interactions can be optimized for disease prevention.
Individualized Nutrition
The promise of nutritional engineering for optimal health through diet is still ongoing, but the public is holding positive expectations, as is evidenced by the use of dietary supplements.
Scientific research is showing that nutrients in different foods and supplements we eat may be able to adjust or reverse heritable changes. This evidence can be used in making better lifestyle choices.
Blueberries are incredibly high in antioxidants and it�s thought that this �superfood� can epigenetically reduce DNA damage, thereby protecting humans against cancer and possibly even slow aging. Blueberry juice and vitamin C have been shown to be potential methylation inhibitors for the MTHFR gene and the DNMT1 gene in humans.
Kim, M., Na, H., Kasai, H., Kawai, K., Li, Y.-S., & Yang, M. (2017). Comparison of Blueberry (Vaccinium spp.) and Vitamin C via Antioxidative and Epigenetic Effects in Human. Journal of Cancer Prevention, 22(3), 174�181.
Learning about what we eat and what it does to our bodies, especially potential epigenetic impact, is just one step closer to optimal health.
Methylation plays a role in a variety of bodily functions, including plasticity. The regulation of DNA methylation is essential for cells to “read” epigenetic patterns. Methylation occurs randomly in regions known as the metastable epialleles. These epigenetic patterns are then passed down to offspring during fetal development, and they will continue to be preserved through multiple generations. How genomic imprinting impacts DNA methylation and plasticity has been demonstrated in a variety of research studies.
Genomic imprinting is tremendously affected by environmental factors. By way of instance, exposure to the fungicide vinclozolin and the pesticide methoxychlor can trigger alterations in epigenetic patterns which can carry over to future generations, regardless of maintained exposure. Environmental factors may also prevent DNA methylation activity, which may cause various health issues.
Genomic Imprinting and DNA Methylation
Nutrient deficiencies required for SAMe biosynthesis and/or DNA methylation activity may lead to permanent nutritional deficits in CpG methylation. Animal research studies have demonstrated that supplements, such as folic acid, vitamin B12, choline, and betaine, during pregnancy can have a considerable, restorative impact on offspring DNA methylation activity and SAMe biosynthesis.
As mentioned above, the preservation of DNA methylation in proliferative cells and/or tissues may also be tremendously affected by nutritional deficiencies in methyl donor status and/or DNA methylation activity. As a matter of fact, DNA de-methylation, which generally develops between the ages of 34 to 68 years old, is considered to be part of the normal aging process. Human research studies have demonstrated that non-age-related alterations in DNA methylation may occur outside crucial fetal developmental stages.
In a research study published in the Lancet, researchers determined that hyperhomocysteinemia, between 16 and 100 ?mol/L plasma or serum, was considerably associated with DNA hypomethylation in humans. The research study participants were between the ages of 39 to 68 years old. Researchers believed that this occurred due to an increase in S-adenosyl homocysteine, or SAH), a powerful inhibitor of SAMe- dependent methyltransferases, including DNMTs. Induced folate deficiencies in the research study participants further worsened hyperhomocysteinemia, and folate treatment decreased plasma total homocysteine and DNA hypomethylation.
Animal research studies also demonstrated that DNA methylation may also be tremendously affected outside the critical fetal developmental stages. Dietary and lifestyle modifications may help restore methylation status. By way of instance, methionine supplements in adult rodent offspring have been demonstrated to reverse DNA methylation changes in the hippocampal glucocorticoid receptor as well as in stress responses, caused by negative maternal behaviors in early life. Moreover, betaine supplements have also been demonstrated to trigger promoter hypermethylation activity on specific genes in porcine liver.
Although the evidence is still limited, and more research studies are required to determine outcome measures, both animal and human research studies demonstrated that alterations in DNA methylation can be caused by nutrient availability, including folate, choline, vitamin B6, and vitamin B12. The outcome measures of many of these research studies suggest that multiple factors, such as food-based modulators on genomic imprinting, lifestyle, and environmental exposures, shape the overall impact on DNA methylation.
DNA methylation has been demonstrated to tremendously affect genomic imprinting associated with nutrient deficiencies and environmental factors. Stress responses may also alter DNA methylation epigenetic patterns which are correlated with gene expression differences. According to the research studies mentioned in the following article, nutrient deficiencies and environmental factors may cause DNA methylation health issues throughout multiple generations. Understanding how DNA methylation affects plasticity is essential for individuals to continue overall health and wellness for future generations.
Dr. Alex Jimenez D.C., C.C.S.T. Insight
Smoothies and Juices for Methylation Support
While many healthcare professionals can recommend nutritional guidelines and lifestyle modifications, there are several alternative treatment options you can try for yourself at home. As described above, however, supplementation for methylation support should be correctly determined by a healthcare professional. Smoothies and juices are a fast and easy way to include all the necessary nutrients you need for methylation support in a single serving. The smoothies and juices below are part of the Methylation Diet Food Plan.
Sea Green Smoothie Servings: 1 Cook time: 5-10 minutes � 1/2 cup cantaloupe, cubed � 1/2 banana � 1 handful of kale or spinach � 1 handful of Swiss chard � 1/4 avocado � 2 teaspoons spirulina powder � 1 cup water � 3 or more ice cubes Blend all ingredients in a high-speed blender until completely smooth and enjoy!
Berry Bliss Smoothie Servings: 1 Cook time: 5-10 minutes � 1/2 cup blueberries (fresh or frozen, preferably wild) � 1 medium carrot, roughly chopped � 1 tablespoon ground flaxseed or chia seed � 1 tablespoons almonds � Water (to desired consistency) � Ice cubes (optional, may omit if using frozen blueberries) Blend all ingredients in a high-speed blender until smooth and creamy. Best served immediately!
Sweet and Spicy Juice Servings: 1 Cook time: 5-10 minutes � 1 cup honeydew melons � 3 cups spinach, rinsed � 3 cups Swiss chard, rinsed � 1 bunch cilantro (leaves and stems), rinsed � 1-inch knob of ginger, rinsed, peeled and chopped � 2-3 knobs whole turmeric root (optional), rinsed, peeled and chopped Juice all ingredients in a high-quality juicer. Best served immediately!
Ginger Greens Juice Servings: 1 Cook time: 5-10 minutes � 1 cup pineapple cubes � 1 apple, sliced � 1-inch knob of ginger, rinsed, peeled and chopped � 3 cups kale, rinsed and roughly chopped or ripped � 5 cups Swiss chard, rinsed and roughly chopped or ripped Juice all ingredients in a high-quality juicer. Best served immediately!
Zesty Beet Juice Servings: 1 Cook time: 5-10 minutes � 1 grapefruit, peeled and sliced � 1 apple, washed and sliced � 1 whole beet, and leaves if you have them, washed and sliced � 1-inch knob of ginger, rinsed, peeled and chopped Juice all ingredients in a high-quality juicer. Best served immediately!
Protein Power Smoothie Serving: 1 Cook time: 5 minutes � 1 scoop protein powder � 1 tablespoon ground flaxseed � 1/2 banana � 1 kiwi, peeled � 1/2 teaspoon cinnamon � Pinch of cardamom � Non-dairy milk or water, enough to achieve desired consistency Blend all ingredients in a high-powered blender until completely smooth. Best served immediately!
ProLon� Fasting Mimicking Diet
alanced methylation support can be achieved through proper nutrition. The ProLon� fasting mimicking diet offers a 5-day meal program which has been individually packed and labeled to serve the foods you need for the FMD in precise quantities and combinations. The meal program is made up of ready-to-eat or easy-to-prepare, plant-based foods, including bars, soups, snacks, supplements, a drink concentrate, and teas. The products are scientifically formulated and great tasting. Before starting the ProLon� fasting mimicking diet, 5-day meal program, please make sure to talk to a healthcare professional to find out if the FMD is right for you. The ProLon� fasting mimicking diet can help promote methylation support, among a variety of other healthy benefits.
Many doctors and functional medicine practitioners may recommend higher doses of methyl donors in several patients, however, further research studies are needed to determine the proper amount of methylation supplementation. The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .
Curated by Dr. Alex Jimenez
Additional Topic Discussion: Acute Back Pain
Back pain is one of the most prevalent causes of disability and missed days at work worldwide. Back pain attributes to the second most common reason for doctor office visits, outnumbered only by upper-respiratory infections. Approximately 80 percent of the population will experience back pain at least once throughout their life. Your spine is a complex structure made up of bones, joints, ligaments, and muscles, among other soft tissues. Injuries and/or aggravated conditions, such as herniated discs, can eventually lead to symptoms of back pain. Sports injuries or automobile accident injuries are often the most frequent cause of back pain, however, sometimes the simplest of movements can have painful results. Fortunately, alternative treatment options, such as chiropractic care, can help ease back pain through the use of spinal adjustments and manual manipulations, ultimately improving pain relief.
Formulas for Methylation Support
XYMOGEN�s Exclusive Professional Formulas are available through select licensed health care professionals. The internet sale and discounting of XYMOGEN formulas are strictly prohibited.
Proudly, Dr. Alexander Jimenez makes XYMOGEN formulas available only to patients under our care.
Please call our office in order for us to assign a doctor consultation for immediate access.
If you are a patient of Injury Medical & Chiropractic Clinic, you may inquire about XYMOGEN by calling 915-850-0900.
For your convenience and review of the XYMOGEN products please review the following link.*XYMOGEN-Catalog-Download
* All the above XYMOGEN policies remain strictly in force.
When a patient comes in with complaints of pain in the shoulder and restricted motion in the joint, one possible diagnosis may be acromicioclavicular (AC) joint injury. While it is often an injury that is common among athletes, it can happen to anyone. Fortunately, chiropractic is a very effective treatment. While most people think of chiropractors, the first thing that comes to mind is back pain. Yes, chiropractors do specialize in back/spine issues, but chiropractic care is used to treat a variety of conditions from joint pain to migraines, fitness, and diet.
What is an acromioclavicular joint injury?
There are two bones, the clavicle, and acromion, that make up the AC joint. Four ligaments hold the joint together. When those ligaments are strained to stress, it results in an AC joint injury, often causing at least some joint separation. AC injuries fall into one of two categories: overuse and traumatic.
Overuse injury occurs over a period of time and is caused by excessive stress on the joint that is repeated or consistent. This causes damage to the cartilage and can lead to AC joint arthritis.
Traumatic injury occurs when the damaged ligaments disrupt the joint called a shoulder separation. This is different from a shoulder dislocation which involves the actual ball and socket shoulder joint.
What causes acromioclavicular joint injury?
The cause of an AC joint injury depends on the type of injury.
Overuse AC joint injuries are caused by overuse and are commonly seen in people who perform tasks that involve lifting heavy weight (including military or bench presses) or that perform physical labor that involves often stretching their arms over their heads.
A fall often causes traumatic AC joint injuries. The person may fall and land on their shoulder or fall on their hand then they put it out to brace their fall. It is often seen in cyclists who are involved in crashes, football players when they are tackles or a laborer who falls from a high place, such as a ladder. These injuries are graded from mild to severe, depending on how much the separation there is in the joint.
What are the symptoms of acromioclavicular joint pain?
A patient with AC joint pain may experience the following symptoms:
A bump that sits above the shoulder and is easily visible
A catching sensation or popping sound when the shoulder moves
Pain and swelling in the shoulder
Loss of range of motion of the shoulder
Loss or decrease in shoulder strength
Tenderness and swelling over the AC joint
Pain when lying on the affected side
Discomfort and pain in the shoulder when performing activities that place stress on the AC joint, including:
Carrying heavy objects at the side
Reaching across the body
Lifting objects overhead
What are the treatments for acromioclavicular joint pain?
Mild cases of traumatic AC joint injuries are often treated with physical therapy and chiropractic. Ice, rest, and immobilization can also be used to manage the pain.
Overuse AC joint injuries can also be treated with immobilization and ice as well as physical therapy and chiropractic. More severe cases may require surgery. Doctors may prescribe muscle relaxants, pain medication, or NSAIDs to help manage the pain.
Is chiropractic for acromioclavicular joint pain effective?
Chiropractic has been proven to be very effective for AC joint pain. The chiropractor performs what is called an AC adjustment which involves manipulation of the shoulder.
While it can be a little uncomfortable for the patient, it is one of the best ways to quickly decrease the pain. After the procedure, the chiropractor may recommend icing the area to minimize or prevent swelling and pain. Regular chiropractic care can ensure continued mobility and continued decrease in pain.
Methylation, also known as one-carbon metabolism, is a biochemical process which triggers methylation activity. A methyl group, one of the most common structural units of organic compounds, is made up of one carbon atom bonded to three hydrogen atoms (-CH3). A methyl group, added or removed from proteins or nucleic acids, can generally be created in two different ways, including by:
The attachment of a hydrogen atom to methylene atoms (-CH2-), promotes the production of the enzyme methylenetetrahydrofolate reductase, or MTHFR. The product of this reaction is known as 5-methylTHF.
The change of a methyl group, such as catechol-O-methyltransferase, also known as COMT, and DNA methyltransferase, also known as DNMT enzymes. DNA methyltransferase enzymes utilize methyl groups from active S-adenosylmethionine or SAMe.
SAMe transforms to S-adenosyl homocysteine, or SAH, and then homocysteine demonstrated in Figure 1. Homocysteine can also convert to methionine through one of two different pathways. The dominant pathway, via methionine synthase conversion, requires the exchange of a methyl group from 5-methyltetrahydrofolate, or 5-mTHF, where it is created by the enzyme methylenetetrahydrofolate reductase, or MTHFR, the most well-known enzyme in the folate metabolic pathways.
A secondary pathway for methionine biosynthesis from homocysteine is via betaine homocysteine methyltransferase, which occurs in the liver and kidneys. Homocysteine may also trigger another biochemical pathway, particularly during states of increased oxidative stress, which transforms homocysteine to cystathionine to taurine, glutathione, or sulfate. The transsulfuration pathway is permanent, however, in order to produce glutathione, homocysteine may be utilized to generate SAMe, among other pathways.
Dietary folate can be found in a variety of foods as substances known as pteropolyglutamates. In order to be absorbed efficiently, the polyglutamate is hydrolyzed in the intestines into a monoglutamate known as tetrahydrofolate or THF. Folic acid, on the other hand, the most well-known synthetic form of the nutrient utilized in food fortification, must be decreased by the enzyme dihydrofolate reductase, or DHFR, twice in the liver where it will need the addition of two hydrogen atoms before it can convert into THF.
Most essentially, DHFR activity may often vary and it may ultimately decrease. DHFR activity in the liver is also 56 times slower in humans, according to research studies, meaning that we should be careful when we translate the pharmacokinetic outcome measures of folic acid in animals. Oftentimes, doctors and functional medicine practitioners will utilize other forms of supplemental folates including 5-mTHF and folinic acid, or 10-formyl THF, to avoid a potential DHFR blockage, and in the case of 5-mTHF, with the purpose to prevent polymorphism blockages at the MTHFR enzyme. Many research studies have demonstrated these findings.
Research studies comparing the effects of 5-mTHF versus folic acid on folate have demonstrated that methylation can also be effective at raising folate levels. Folinic acid is sometimes utilized to support cerebral folate levels in certain circumstances where auto-antibodies transport folate to proteins at the blood-brain barrier. Understanding the biochemistry of methylation is only the introduction to methylation. Nutrition and lifestyle modifications have been demonstrated to help with methylation support.
Methylation, the transfer of a methyl group to an organic compound, can be divided into two basic types: chemical and biological. The regulation of methylation in the human body is promoted through modifications to DNA and that of proteins or enzymes. The purpose of the following article is to demonstrate how chemical and biological factors play a role in the regulation of DNA methylation. Understanding these processes is important towards improving a patient’s overall health and wellness.
Dr. Alex Jimenez D.C., C.C.S.T. Insight
Smoothies and Juices for Methylation Support
While many healthcare professionals can recommend nutritional guidelines and lifestyle modifications, there are several alternative treatment options you can try for yourself at home. As described above, however, supplementation for methylation support should be correctly determined by a healthcare professional. Smoothies and juices are a fast and easy way to include all the necessary nutrients you need for methylation support in a single serving. The smoothies and juices below are part of the Methylation Diet Food Plan.
Sea Green Smoothie Servings: 1 Cook time: 5-10 minutes � 1/2 cup cantaloupe, cubed � 1/2 banana � 1 handful of kale or spinach � 1 handful of Swiss chard � 1/4 avocado � 2 teaspoons spirulina powder � 1 cup water � 3 or more ice cubes Blend all ingredients in a high-speed blender until completely smooth and enjoy!
Berry Bliss Smoothie Servings: 1 Cook time: 5-10 minutes � 1/2 cup blueberries (fresh or frozen, preferably wild) � 1 medium carrot, roughly chopped � 1 tablespoon ground flaxseed or chia seed � 1 tablespoons almonds � Water (to desired consistency) � Ice cubes (optional, may omit if using frozen blueberries) Blend all ingredients in a high-speed blender until smooth and creamy. Best served immediately!
Sweet and Spicy Juice Servings: 1 Cook time: 5-10 minutes � 1 cup honeydew melons � 3 cups spinach, rinsed � 3 cups Swiss chard, rinsed � 1 bunch cilantro (leaves and stems), rinsed � 1-inch knob of ginger, rinsed, peeled and chopped � 2-3 knobs whole turmeric root (optional), rinsed, peeled and chopped Juice all ingredients in a high-quality juicer. Best served immediately!
Ginger Greens Juice Servings: 1 Cook time: 5-10 minutes � 1 cup pineapple cubes � 1 apple, sliced � 1-inch knob of ginger, rinsed, peeled and chopped � 3 cups kale, rinsed and roughly chopped or ripped � 5 cups Swiss chard, rinsed and roughly chopped or ripped Juice all ingredients in a high-quality juicer. Best served immediately!
Zesty Beet Juice Servings: 1 Cook time: 5-10 minutes � 1 grapefruit, peeled and sliced � 1 apple, washed and sliced � 1 whole beet, and leaves if you have them, washed and sliced � 1-inch knob of ginger, rinsed, peeled and chopped Juice all ingredients in a high-quality juicer. Best served immediately!
Protein Power Smoothie Serving: 1 Cook time: 5 minutes � 1 scoop protein powder � 1 tablespoon ground flaxseed � 1/2 banana � 1 kiwi, peeled � 1/2 teaspoon cinnamon � Pinch of cardamom � Non-dairy milk or water, enough to achieve desired consistency Blend all ingredients in a high-powered blender until completely smooth. Best served immediately!
ProLon� Fasting Mimicking Diet
alanced methylation support can be achieved through proper nutrition. The ProLon� fasting mimicking diet offers a 5-day meal program which has been individually packed and labeled to serve the foods you need for the FMD in precise quantities and combinations. The meal program is made up of ready-to-eat or easy-to-prepare, plant-based foods, including bars, soups, snacks, supplements, a drink concentrate, and teas. The products are scientifically formulated and great tasting. Before starting the ProLon� fasting mimicking diet, 5-day meal program, please make sure to talk to a healthcare professional to find out if the FMD is right for you. The ProLon� fasting mimicking diet can help promote methylation support, among a variety of other healthy benefits.
Many doctors and functional medicine practitioners may recommend higher doses of methyl donors in several patients, however, further research studies are needed to determine the proper amount of methylation supplementation. The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .
Curated by Dr. Alex Jimenez
Additional Topic Discussion: Acute Back Pain
Back pain is one of the most prevalent causes of disability and missed days at work worldwide. Back pain attributes to the second most common reason for doctor office visits, outnumbered only by upper-respiratory infections. Approximately 80 percent of the population will experience back pain at least once throughout their life. Your spine is a complex structure made up of bones, joints, ligaments, and muscles, among other soft tissues. Injuries and/or aggravated conditions, such as herniated discs, can eventually lead to symptoms of back pain. Sports injuries or automobile accident injuries are often the most frequent cause of back pain, however, sometimes the simplest of movements can have painful results. Fortunately, alternative treatment options, such as chiropractic care, can help ease back pain through the use of spinal adjustments and manual manipulations, ultimately improving pain relief.
Formulas for Methylation Support
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