Back Clinic Epigenetics Functional Medicine Team. The study of heritable changes in gene expression (active versus inactive genes) does not involve changes to the DNA sequence, a change in phenotype without a change in genotype, which affects how cells read genes. An epigenetic change is a regular, natural occurrence that can also be influenced by several factors: age, environment, lifestyle, and disease state. Epigenetic modifications can commonly manifest as how cells terminally differentiate into skin cells, liver cells, brain cells, etc. And epigenetic change can have more damaging effects that can result in diseases.
New and ongoing research is continuously uncovering the role of epigenetics in a variety of human disorders and fatal diseases. Epigenetic marks are more stable during adulthood. However, they are still thought to be dynamic and modifiable by lifestyle choices and environmental influence. It is becoming apparent that epigenetic effects do not just occur in the womb but over the full course of human life. Another discovery is that epigenetic changes can be reversed. Numerous examples of epigenetics show how different lifestyle choices and environmental exposures can alter marks on DNA and play a role in determining health outcomes.
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