Doctor consulting patient with stomach pain at table in clinic, back view
Contents
A woman is experiencing gut pain symptoms after sustaining a head injury in a motor vehicle crash.
Traumatic brain injury, often called TBI, happens when a sudden blow or jolt to the head disrupts normal brain function. This can range from mild concussions to severe cases that change lives forever. However, many people are unaware that TBI doesn’t just affect the head—it can also impact the entire body, particularly the gut. The gut and brain communicate with each other constantly through a network known as the gut-brain axis. When TBI occurs, this chat becomes disrupted, leading to issues such as leaky gut, imbalanced gut bacteria, and poor digestion. These issues can exacerbate the brain injury by spreading inflammation throughout the body. On the other hand, simple changes like chiropractic adjustments may help alleviate issues by calming nerves, reducing inflammation, and strengthening the gut-brain connection.
In this article, we’ll break down how TBI harms the gut, the symptoms it causes, and why the gut matters for healing the brain. We’ll also examine how integrative chiropractic therapy—think spinal adjustments to enhance nerve signals—can alleviate digestive issues and promote recovery. Drawing from recent studies and expert insights, we’ll keep it straightforward so you can grasp the science without getting lost in jargon.
TBI strikes about 69 million people worldwide each year, from car crashes to sports hits (Dhar et al., 2024). Right after the injury, the brain swells and releases signals that stress the body. This stress doesn’t stay in the head; it travels down nerves and hormones to the belly. The gut-brain axis is like a two-way street: the brain instructs the gut when to digest food, and the gut sends back signals that influence mood and focus.
When TBI blocks this street, the gut suffers. One significant change is increased gut permeability, also known as “leaky gut.” Normally, the gut wall acts like a tight filter, letting nutrients in but keeping junk out. After a TBI, that filter loosens, allowing bacteria and toxins to slip into the blood. This sparks body-wide inflammation, which in turn inflames the brain further (Nicholson et al., 2019).
Here’s a quick list of how TBI disrupts the gut-brain axis:
These changes don’t just cause tummy troubles—they can drag out brain fog, fatigue, and even raise risks for long-term issues like depression or Alzheimer’s (Nicholson et al., 2019). Restoring the gut could significantly contribute to the recovery from traumatic brain injury.
Your gut isn’t just for breaking down lunch; it’s a powerhouse for brain health. It houses trillions of bacteria—the microbiome—that make feel-good chemicals like serotonin, which boosts mood and sleep. Approximately 90% of serotonin originates from the gut, rather than the brain (Nicholson et al., 2019). After a TBI, this factory slows down, leaving you irritable or exhausted.
The gut also absorbs key nutrients essential for brain repair, such as omega-3s for nerve growth and B vitamins for energy. When gut issues arise, you miss them, stalling the healing process. Additionally, healthy gut bacteria combat inflammation, facilitating the brain’s ability to rewire itself through neuroplasticity—the brain’s capacity to form new neural pathways.
Studies indicate that TBI patients with gut imbalances have slower recovery and more cognitive slips (Hassan et al., 2020). However, nourishing the gut with the right foods or therapies can help reverse the situation.
Leaky gut starts fast after TBI—sometimes in hours. Brain trauma intensifies stress responses, flooding the body with catecholamines that disrupt the gut’s tight junctions, the “zippers” that hold cells together (Pitman et al., 2021). Proteins like occludin and ZO-1 break down, letting bacteria sneak out.
This leakage triggers a firestorm: toxins enter the bloodstream, activating immune cells to release cytokines such as TNF-α and IL-6. These chemicals not only inflame the gut but also travel to the brain, fueling secondary damage (Dhar et al., 2024). In one study, TBI mice exhibited 2.5 times more gut leaks, which was linked to higher mortality rates from infections (Nicholson et al., 2019).
Dysbiosis, or bacterial imbalance, worsens. TBI alters the microbiome, with harmful bacteria, such as Proteobacteria, proliferating while beneficial ones, like Firmicutes, decline (Wang et al., 2021). This imbalance reduces SCFA production, which normally helps soothe inflammation. Human data support this—patients post-TBI have altered gut microbiomes for years, linked to poorer cognitive skills (Hassan et al., 2020).
Key signs of this gut takeover include:
Breaking this loop is crucial; without it, TBI recovery stalls (Cognitive FX, 2023).
TBI’s gut punch shows up in everyday gripes that sap energy and joy. Nausea strikes hard early on, often accompanied by vomiting or dry heaves, making eating a chore (Cognitive FX, 2023). Constipation is sneaky—slowed nerves mean food lingers too long, causing hard stools and belly pain. Diarrhea flips the script, from bacterial overgrowth or stress.
Other hits:
These aren’t just annoyances; they link to brain symptoms. For example, gut inflammation can amp up headaches or dizziness (Flint Rehab, 2023). In severe cases, feeding intolerance affects up to 50% of patients, hiking infection risks (Dhar et al., 2024). Spotting these early lets you act fast.
Inflammation is the troublemaker tying gut woes to brain hurt. After a TBI, damaged brain cells release danger signals (DAMPs) that alert the immune system. This revs up gut cytokines, which leak through the damaged wall and reach the brain, causing swelling of neurons (Pitman et al., 2021).
The gut, which contains 70% of immune cells, amplifies this process. Dysbiosis releases pro-inflammatory signals, while low SCFAs allow swelling to run rampant (Wang et al., 2021). Result? A body-wide storm that delays healing and sparks issues like epilepsy or PTSD (Hassan et al., 2020).
Taming this fire is key; therapies that cool gut swelling often ease brain fog too (Nicholson et al., 2019).
The enteric nervous system (ENS), your gut’s own nerve web, acts like a mini-brain, controlling wiggles and juices. TBI zaps it via vagus glitches and hormone floods, leading to dysfunction (Nicholson et al., 2019). Serotonin levels in the colon decrease, slowing peristalsis—the wave that propels food through the digestive tract (Traumatic brain injury alters the gut-derived serotonergic system, 2022).
This means gastroparesis (stomach paralysis) or spasms, which can worsen leaks and dysbiosis. ENS glia, support cells, become reactive, adding to swelling (Dhar et al., 2024). In patients, this ties to incontinence or pain lasting months.
Quick facts on ENS fallout:
Restoring ENS flow could smooth digestion and brain signals alike.
Integrative chiropractic care excels in this area, utilizing spinal adjustments to optimize the nervous system. Misaligned vertebrae, common after TBI whiplash, pinch nerves and disrupt gut chats (Auburn Chiropractors, 2023). Adjustments realign the spine, easing pressure and boosting vagus tone to promote better motility and reduced swelling.
How it helps:
Dr. Alexander Jimenez, a chiropractor with over 20 years in functional medicine, observes this in practice. At his clinic, TBI patients report less nausea and steadier bowels after adjustments, thanks to better spine-gut links. “Spinal care isn’t just for backs—it’s key to whole-body healing, including the gut-brain tie,” Jimenez notes in his wellness posts (Jimenez, 2023). His approach combines adjustments with nutrition, aligning with research on multi-modal solutions.
Patients under chiropractic care see quick wins. Adjustments lower cortisol, easing stress that tightens gut junctions (Eugene Chiropractor, 2023). A study-linked review shows reduced gastrointestinal symptoms in brain injury cases through vagus stimulation (Northwest Florida Physicians Group, 2023).
Benefits include:
When combined with probiotics, it becomes a potent combination—Jimenez frequently pairs them for microbiome resets (Jimenez, 2023).
Chiropractic isn’t a solo approach; it often teams with diet and supplements. Eat anti-inflammatory foods like salmon and greens to feed beneficial bacteria (Flint Rehab, 2023). Probiotics, such as Lactobacillus, help rebuild diversity by reducing cytokines (Li et al., 2024).
Jimenez emphasizes the importance of personalization: “Tailor care to the patient’s axis—test microbiome, adjust spine, track progress” (Jimenez, 2023). This holistic approach aligns with studies on enteral nutrition following TBI (Zhang et al., 2024).
Gut fixes post-TBI pay off big. Early action reduces chronic risks, such as neurodegeneration (Wang et al., 2021). Patients with balanced microbiomes show better memory and mood years out (Hassan et al., 2020).
Future paths? More trials on chiropractic for TBI patients, according to experts (Psychology Today, 2025b). Jimenez pushes for integrated clinics: “Chiro plus gut therapy—it’s the future for TBI survivors.”
TBI disrupts the gut-brain axis, but knowledge and action can help rebuild it. From leaky gut to dysbiosis, these hits cause real pain—but chiropractic offers a gentle reset. Start with a check-up, tweak your plate, and align your spine. Your body thanks you.
Auburn Chiropractors. (2023). Traumatic brain injury & the leaky gut connection. https://www.theauburnchiropractors.com/blog/214636-traumatic-brain-injury-amp-the-leaky-gut-connection
Cognitive FX. (2023). Post-concussion stomach problems: Loss of appetite, pain, & more. https://www.cognitivefxusa.com/blog/concussion-loss-of-appetite-and-other-stomach-problems
Dhar, R., et al. (2024). Dysregulated brain-gut axis in the setting of traumatic brain injury: Review of mechanisms and anti-inflammatory pharmacotherapies. PMC, 11083845. https://pmc.ncbi.nlm.nih.gov/articles/PMC11083845/
Eugene Chiropractor. (2023). Can chiropractic care improve your gut health? https://www.eugenechiropractor.com/blog/posts/can-chiropractic-care-improve-your-gut-health
Flint Rehab. (2023). Brain injury and gut health: Looking at the gut-brain axis. https://www.flintrehab.com/brain-injury-and-gut-health/
Hassan, T. H., et al. (2020). The gut-brain axis in traumatic brain injury: Literature review. Journal of Clinical Neuroscience. https://www.sciencedirect.com/science/article/abs/pii/S0967586825002309
Jimenez, A. (2023). Injury specialists. https://dralexjimenez.com/
Li, Y., et al. (2024). Probiotics in traumatic brain injury: New insights into mechanisms and future perspectives. PMC, 11313054. https://pmc.ncbi.nlm.nih.gov/articles/PMC11313054/
Nicholson, S. E., et al. (2019). The gut reaction to traumatic brain injury. PMC, 5019014. https://pmc.ncbi.nlm.nih.gov/articles/PMC5019014/
Northwest Florida Physicians Group. (2023). Using chiropractic care to treat traumatic brain injuries. https://northwestfloridaphysiciansgroup.com/using-chiropractic-care-to-treat-traumatic-brain-injuries/
Pitman, S., et al. (2021). Brain-gut axis dysfunction in the pathogenesis of traumatic brain injury. PMC, 8203445. https://pmc.ncbi.nlm.nih.gov/articles/PMC8203445/
Psychology Today. (2025a). Fixing the gut-brain chaos after head injury. https://www.psychologytoday.com/us/blog/your-brain-on-food/202501/fixing-the-gut-brain-chaos-after-head-injury
Psychology Today. (2025b). The gut-brain-spine connection. https://www.psychologytoday.com/us/blog/the-leading-edge/202503/the-gut-brain-spine-connection
Traumatic brain injury alters the gut-derived serotonergic system and associated peripheral organs. (2022). Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease. https://www.sciencedirect.com/science/article/pii/S0925443922001624
Wang, L., et al. (2021). Diet-microbiome-gut-brain nexus in acute and chronic brain injury. PMC, 9523267. https://pmc.ncbi.nlm.nih.gov/articles/PMC9523267/
Zhang, Y., et al. (2024). Research progress on digestive disorders following traumatic brain injury. PMC, 11695231. https://pmc.ncbi.nlm.nih.gov/articles/PMC11695231/
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The information on "Brain Injuries and Stomach Problems: How They Relate" is not intended to replace a one-on-one relationship with a qualified health care professional or licensed physician and is not medical advice. We encourage you to make healthcare decisions based on your research and partnership with a qualified healthcare professional.
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Welcome to the wellness blog of El Paso Back Clinic, where Dr. Alex Jimenez, DC, FNP-C, a board-certified Family Practice Nurse Practitioner (FNP-C) and Chiropractor (DC), presents insights on how our team is dedicated to holistic healing and personalized care. Our practice aligns with evidence-based treatment protocols inspired by integrative medicine principles, similar to those found on dralexjimenez.com, focusing on restoring health naturally for patients of all ages.
Our areas of chiropractic practice include Wellness & Nutrition, Chronic Pain, Personal Injury, Auto Accident Care, Work Injuries, Back Injury, Low Back Pain, Neck Pain, Migraine Headaches, Sports Injuries, Severe Sciatica, Scoliosis, Complex Herniated Discs, Fibromyalgia, Chronic Pain, Complex Injuries, Stress Management, Functional Medicine Treatments, and in-scope care protocols.
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