There is more evidence that the active ingredient in turmeric may have the power to help combat malignant mesothelioma.
A new French study on curcumin finds that the compound not only slowed the growth of one of the rarest types of mesothelioma tumor cells in the laboratory but also reduced total tumor mass in lab rats in just two weeks.
Contents
Curcumin, the plant polyphenol that gives turmeric its yellow hue and pungent flavor, has been the subject of numerous malignant mesothelioma studies in recent years, in part because of its powerful anti-inflammatory properties.
In the newest study, the French researchers focused on one of the rarest and deadliest subtypes of the asbestos cancer � sarcomatoid mesothelioma.
First, they used sarcomatoid mesothelioma cells from rats that had been induced to develop mesothelioma by exposing them to asbestos. By testing curcumin on the mesothelioma cells first, the research team was able to determine the optimal curcumin concentration and dose to use on the live rats.
With dosing established, the researchers administered curcumin directly into the peritoneal cavities of sick mice. For comparison, a second group of rats was treated with an epigenetic drug called SAHA.
�The treatment of tumor-bearing rats with 1.5 mg/kg curcumin on days 7, 9, 11 and 14 after tumor challenge dramatically reduced the mean total tumor mass at day 16,� writes researcher Daniel L. Pouliquen in the journal Oncotarget.
The study found that both curcumin and SAHA produced necrosis or dead tissue within the mesothelioma tumors by day 28, but the necrosis induced by curcumin was �much more extensive�.
In addition, curcumin appeared to attract cancer-fighting CD8+ T lymphocytes to the area which clustered around small residual mesothelioma tumors in the peritoneal cavity after treatment.
�These data open up interesting new prospects for the therapy of sarcomatoid mesothelioma with curcumin and its derivatives,� concludes Dr. Pouliquen.
Earlier this year, scientists in the Department of Experimental Medicine at the University of Rome conducted a similar experiment and that found that intraperitoneal curcumin extended survival in mice with mesothelioma.
In 2015, mesothelioma researchers with Flinders University in Australia determined that curcumin had the ability to keep mesothelioma tumors from giving rise to their own new blood vessels. That study suggested that curcumin could become a supplemental treatment for certain mesothelioma patients.
Source: Pouliquen, DL, et al, �Evaluation of intracavitary administration of curcumin for the treatment of sarcomatoid mesothelioma�, February 25, 2017, Oncotarget, Epub ahead of print
Author
Alex Strauss
As always… Check with your doctors before you rely on this information. �I bring it to you because it does give great insight into Curcumin so many people are raving about.
It should be noted that Mesothelioma is a very serious disorder requiring the expertise of top level Oncologist. � Great Regards. Dr. Alex Jimenez
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The information herein on "New Prospects for Treating Malignant Mesothelioma with Curcumin" is not intended to replace a one-on-one relationship with a qualified health care professional or licensed physician and is not medical advice. We encourage you to make healthcare decisions based on your research and partnership with a qualified healthcare professional.
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Dr. Alex Jimenez, DC, MSACP, APRN, FNP-BC*, CCST, IFMCP, CFMP, ATN
email: coach@elpasofunctionalmedicine.com
Multidisciplinary Licensing & Board Certifications:
Licensed as a Doctor of Chiropractic (DC) in Texas & New Mexico*
Texas DC License #: TX5807, Verified: TX5807
New Mexico DC License #: NM-DC2182, Verified: NM-DC2182
Multi-State Advanced Practice Registered Nurse (APRN*) in Texas & Multi-States
Multi-state Compact APRN License by Endorsement (42 States)
Texas APRN License #: 1191402, Verified: 1191402 *
Florida APRN License #: 11043890, Verified: APRN11043890 *
Colorado License #: C-APN.0105610-C-NP, Verified: C-APN.0105610-C-NP
New York License #: N25929, Verified N25929
License Verification Link: Nursys License Verifier
* Prescriptive Authority Authorized
ANCC FNP-BC: Board Certified Nurse Practitioner*
Compact Status: Multi-State License: Authorized to Practice in 40 States*
Graduate with Honors: ICHS: MSN-FNP (Family Nurse Practitioner Program)
Degree Granted. Master's in Family Practice MSN Diploma (Cum Laude)
Dr. Alex Jimenez, DC, APRN, FNP-BC*, CFMP, IFMCP, ATN, CCST
(Board Certified: Family Practice Nurse Practitioner—Multistate)*
(Licensed Nurse Practitioner & Chiropractor - Multistate)*
Clinical Director
Digital Business Card
Dr. Maria Cardenas, MD
(Board Certified: Internal Medicine)
(Licensed Medical Doctor)
Medical Director, Clinical Director & Collaborative Physician
NPI # 1164426749
MD License #: J2933
Licenses and Board Certifications:
MD: Medical Doctor
DC: Doctor of Chiropractic
APRNP: Advanced Practice Registered Nurse
FNP-BC: Family Practice Specialization (Multi-State Board Certified)
RN: Registered Nurse (Multi-State Compact License)
CFMP: Certified Functional Medicine Provider
MSN-FNP: Master of Science in Family Practice Medicine
MSACP: Master of Science in Advanced Clinical Practice
IFMCP: Institute of Functional Medicine
CCST: Certified Chiropractic Spinal Trauma
ATN: Advanced Translational Neutrogenomics
Memberships & Associations:
TCA: Texas Chiropractic Association: Member ID: 104311
AANP: American Association of Nurse Practitioners: Member ID: 2198960
ANA: American Nurse Association: Member ID: 06458222 (District TX01)
TNA: Texas Nurse Association: Member ID: 06458222
NPI: 1205907805
| Primary Taxonomy | Selected Taxonomy | State | License Number |
|---|---|---|---|
| No | 111N00000X - Chiropractor | NM | DC2182 |
| Yes | 111N00000X - Chiropractor | TX | DC5807 |
| Yes | 363LF0000X - Nurse Practitioner - Family | TX | 1191402 |
| Yes | 363LF0000X - Nurse Practitioner - Family | FL | 11043890 |
| Yes | 363LF0000X - Nurse Practitioner - Family | CO | C-APN.0105610-C-NP |
| Yes | 363LF0000X - Nurse Practitioner - Family | NY | N25929 |
Dr. Alex Jimenez, DC, APRN, FNP-BC*, CFMP, IFMCP, ATN, CCST
(Board Certified: Family Practice Nurse Practitioner—Multistate)*
(Licensed Nurse Practitioner & Chiropractor - Multistate)*
Clinical Director
Digital Business Card
Dr. Maria Cardenas, MD
(Board Certified: Internal Medicine)*
(Licensed Medical Doctor)*
Medical Director, Clinical Director & Collaborative Physician
NPI # 1164426749
MD License #: J2933
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