BOOK ONLINE 24/7

Stop Suffering!

  • Quick n' Easy Online Appointment
  • Book Appointment 24/7
  • Call Office: 915-850-0900.
*
Monday8:30 AM - 7:00 PM
Tuesday8:30 AM - 7:00 PM
Wednesday8:30 AM - 7:00 PM
Thursday8:30 AM - 7:00 PM
Friday8:30 AM - 7:00 PM
Saturday8:30 AM - 1:00 PM
SundayClosed

Doctor Cell Emergencies 915-540-8444

BOOK ONLINE 24/7
Functional Medicine

Notice: As part of our Acute Injury Treatment Practice, we now offer Functional Medicine Integrative Assessments and Treatments* within our clinical scope for chronic degenerative disorders. Learn More* Call Us Today: 915-850-0900

Functional Medicine Explained
Clinical Neurophysiology

Neuropathic Pain And Neurogenic Inflammation | El Paso, TX.

Share

If the sensory system becomes impacted by injury or disease, the nerves in that system can’t function in the transmitting of sensation to the brain. This can lead to a sensation of numbness, or lack of sensation. In some cases when the sensory system is injured, individuals can experience pain in the affected region. Neuropathic pain does not start quickly or ends quickly. It’s a chronic condition that leads to�symptoms of persistent pain. For many, the intensity of the symptoms can come and go throughout a day. Neuropathic pain is thought to be associated with peripheral nerve problems, i.e. neuropathy caused by diabetes, spinal stenosis, injury to the brain or spinal cord can also lead to chronic neuropathic pain.

NEUROPATHIC PAIN

Objectives:

  • What is it?
  • What is the pathophysiology behind it?
  • What are the causes
  • What are some of the pathways
  • How can we fix it?

NEUROPATHIC PAIN

  • Pain initiated or caused by a primary lesion or dysfunction in the somatosensory nervous system.
  • Neuropathic pain is usually chronic, difficult to treat and often resistant to standard analgesic management.

PATHOGENESIS OF NEUROPATHIC PAIN

  • PERIPHERAL MECHANISMS
  • After a peripheral nerve lesion, neurons become more sensitive and develop abnormal excitability and elevated sensitivity to stimulation
  • This is known as…Peripheral Sensitization!

  • CENTRAL MECHANISMS
  • As a consequence of ongoing spontaneous activity arising in the periphery, neurons develop an increased background activity, enlarged receptive fields and increased responses to afferent impulses, including normal tactile stimuli
  • This is known as…Central Sensitization!

COMMON CAUSES

Lesions or diseases of the somatosensory nervous system can lead to altered and disordered transmission of sensory signals into the spinal cord and the brain; common conditions associated with neuropathic pain include:

  • Postherpetic neuralgia
  • Trigeminal neuralgia
  • Painful radiculopathy
  • Diabetic neuropathy
  • HIV infection
  • Leprosy
  • Amputation
  • Peripheral nerve injury pain
  • Stroke (in the form of central post-stroke pain)

PHANTOM LIMB PAIN & AUGMENTED REALITY

  • Phantom Limb Pain and AR

NEUROGENIC INFLAMMATION

Objectives:

  • What is it?
  • What is the pathophysiology behind it?
  • What are the causes
  • How can we fix it?

NEUROGENIC INFLAMMATION

  • Neurogenic inflammation is a neurally elicited, local inflammatory response characterized by vasodilation, increased vascular permeability, mast cell degranulation, and the release of neuropeptides including SP and calcitonin gene-related peptide (CGRP)
  • It appears to play an important role in the pathogenesis of numerous disease including migraine, psoriasis, asthma, fibromyalgia, eczema, rosacea, dystonia and multiple chemical sensitivity

COMMON CAUSES

  • There are multiple pathways by which neurogenic inflammation may be initiated. It is well documented, using both animal models and isolated neurons in vitro, that capsaicin, heat, protons, bradykinin, and tryptase are upstream regulators of the intracellular calcium influx, which results in inflammatory neuropeptide release. In contrast, it is thought that prostaglandins E2 and I2, cytokines, interleukin-1, interleukin-6, and tumor necrosis factor do not cause neurotransmitter release themselves, but rather excite sensory neurons and thus lower the threshold for firing and cause augmented release of neuropeptides.
  • While neurogenic inflammation has been extensively studied and well documented in peripheral tissues, until recently the concept of neurogenic inflammation within the CNS has remained largely unexplored. Given the capacity for neurogenic inflammation to influence vascular permeability and lead to the genesis of edema, it has now been widely investigated for its potential to influence BBB permeability and vasogenic edema within the brain and spinal cord under varying pathological conditions.

Anatomy Of The Brain

Post Disclaimer & Professional Scope of Practice *

The information herein on "Neuropathic Pain And Neurogenic Inflammation | El Paso, TX." is not intended to replace a one-on-one relationship with a qualified health care professional, licensed physician, and is not medical advice. We encourage you to make your own health care decisions based on your research and partnership with a qualified health care professional.

Our information scope is limited to chiropractic, musculoskeletal, physical medicines, wellness, sensitive health issues, functional medicine articles, topics, and discussions. We provide and present clinical collaboration with specialists from a wide array of disciplines. Each specialist is governed by their professional scope of practice and their jurisdiction of licensure. We use functional health & wellness protocols to treat and support care for the injuries or disorders of the musculoskeletal system.

Our videos, posts, topics, subjects, and insights cover clinical matters, issues, and topics that relate to and support, directly or indirectly, our clinical scope of practice.*

Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We provide copies of supporting research studies available to regulatory boards and the public upon request.

We understand that we cover matters that require an additional explanation of how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.

We are here to help you and your family.

Blessings

Dr. Alex Jimenez DC, MSACP, CCST, IFMCP*, CIFM*, ATN*

email: coach@elpasofunctionalmedicine.com

Licensed in: Texas & New Mexico*

Dr Alex Jimenez

Welcome-Bienvenido's to our blog. We focus on treating severe spinal disabilities and injuries. We also treat Sciatica, Neck and Back Pain, Whiplash, Headaches, Knee Injuries, Sports Injuries, Dizziness, Poor Sleep, Arthritis. We use advanced proven therapies focused on optimal mobility, health, fitness, and structural conditioning. We use Individualized Diet Plans, Specialized Chiropractic Techniques, Mobility-Agility Training, Adapted Cross-Fit Protocols, and the "PUSH System" to treat patients suffering from various injuries and health problems. If you would like to learn more about a Doctor of Chiropractic who uses advanced progressive techniques to facilitate complete physical health, please connect with me. We focus on simplicity to help restore mobility and recovery. I'd love to see you. Connect!

Published by

Recent Posts

The Size of A Herniated Disc

Herniated discs, although common, can be challenging to treat depending on the size. Over 3mm… Read More

Calf Soreness, Pain and Chiropractic Treatment

Calf pain is common in individuals that are on their feet for long periods. This… Read More

Chiropractic Helps With Stress, Posture, Mood, Immunity, and Sleep

Chiropractic medicine is used as a standard musculoskeletal injury/strain treatment and for rehabilitation. Chiropractic helps… Read More

Weight Loss and Whole Body Chiropractic

Chiropractic medicine specializes in the musculoskeletal system. It treats the whole body because if one… Read More

Using Heat and Ice For A Pinched Nerve

Most if not all of us have probably used heat and/or ice on a sprain,… Read More

Rheumatoid Arthritis Flare-Ups Management

Managing rheumatoid arthritis is an ongoing balancing act. Flare-ups can still present despite following the… Read More

Online History & Registration 🔘
Call us Today 🔘