Risks of Methylation Supplementation

Benefits of Methylation Support

Many people with health issues associated with genetic SNPs due to abnormal methylation cycles, such as MTHFR, can tremendously benefit from DNA methylation support. Patients demonstrating imbalances in methylation metabolites, including elevated homocysteine, decreased SAMe, increased SAH, and a low SAMe:SAH ratio, can also benefit from DNA methylation support. Any individual who has insufficient levels of methyl donors due to poor nutrient status or malabsorption, especially with folate and vitamin B12 deficiencies, stress, hormone imbalances, and even older individuals, can benefit from DNA methylation support. �

Potential Risks of Methylation Supplements

Doctors and functional medicine practitioners commonly utilize natural supplementation for methylation support, however, many other healthcare professionals still frequently utilize synthetic supplementation. According to research studies, using synthetic supplements can cause a variety of health issues. Potential risks of using synthetic folic acid (FA) with unknown mechanisms include an increased risk for allergic diseases and IBD in children of mothers with an increased folic acid intake, impaired natural killer cell activity, insulin resistance in children, embryonic loss and growth delay, and diabetic comorbidity, among other health issues. � Moreover, using unmetabolized folic acid (FA) for methylation support can cause potential genotoxicity, according to research studies. Furthermore, the use of DHF, an intermediate of the DHFR enzyme, can inhibit thymidylate synthase and it can also inhibit MTHF, known as a pseudo MTHFR deficiency. Many more doctors and functional medicine practitioners prefer to utilize natural supplementation over synthetic supplementation for methylation support, to prevent any health issues due to potential risks. The use of 5mTHF and methylcobalamin (vitamin B12) is commonly utilized in functional medicine to avoid folic acid problems. � However, although the use of 5mTHF and methylcobalamin (vitamin B12) bypasses MTHFR enzyme deficits, not enough research studies have been conducted regarding the long-term safety and effectiveness of high doses of 5mTHF or methyl-B12 for methylation support. It’s essential for patients to seek professional help from a qualified and experienced doctor and functional medicine practitioner to determine the best type of supplementation for methylation support. Supplements for methylation support are recommended alongside proper nutrition, fitness, and lifestyle habits to naturally promote DNA methylation status and activity. �

Folate/B12 and Autism: Possible Connection

A recent press release of preliminary evidence findings from the Johns Hopkins research study determined that in 1,391 mother-child pairs in a Boston Birth Cohort, the highest maternal levels of vitamin B12, more than 600 pmol/L, and folate, equal to 59 nmol/L, had an increased risk of causing ASD. The risks were ultimately higher when both were combined. The research study demonstrated no risk difference based on MTHFR genotype or homocysteine. The full-paper has not been published and further research studies are still required to determine the outcome measures of supplementation for methylation support for pregnant women and children. �

Promoting methylation support is an essential process towards maintaining overall health and wellness. Although several research studies have demonstrated potential risks for certain types of supplementation for methylation support, healthcare professionals can help determine the proper supplements to promote methylation support. The purpose of the following article is to discuss the potential risks of supplementation for methylation support. It’s fundamental to understand how nutrition, lifestyle habits, supplements, and medicines, can improve DNA methylation, health and wellness. – Dr. Alex Jimenez D.C., C.C.S.T. Insight

Smoothies and Juices for Methylation Support

While many healthcare professionals can recommend nutritional guidelines and lifestyle modifications to improve methylation support, there�are several options you can try yourself at home. As described above, methylation support supplementation should be determined by a healthcare professional. Smoothies and juices are a fast and easy way to include all the necessary nutrients you need for methylation support without any side-effects. The smoothies and juices below are part of the Methylation Diet Food Plan.

Sea Green Smoothie Servings: 1 Cook time: 5-10 minutes

• 1/2 cup cantaloupe, cubed
• 1/2 banana
• 1 handful of kale or spinach
• 1 handful of Swiss chard
• 1/4 avocado
• 2 teaspoons spirulina powder
• 1 cup of water
• 3 or more ice cubes

Blend all ingredients in a high-speed blender until completely smooth and enjoy!

Berry Bliss Smoothie Servings: 1 Cook time: 5-10 minutes

• 1/2 cup blueberries (fresh or frozen, preferably wild)
• 1 medium carrot, roughly chopped
• 1 tablespoon ground flaxseed or chia seed
• 1 tablespoons almonds
• Water (to desired consistency)
• Ice cubes (optional, may omit if using frozen blueberries)

Blend all ingredients in a high-speed blender until smooth and creamy. Best served immediately!

Sweet and Spicy Juice Servings: 1 Cook time: 5-10 minutes

• 1 cup honeydew melons
• 3 cups spinach, rinsed
• 3 cups Swiss chard, rinsed
• 1 bunch cilantro (leaves and stems), rinsed
• 1-inch knob of ginger, rinsed, peeled and chopped
• 2-3 knobs whole turmeric root (optional), rinsed, peeled and chopped

Juice all ingredients in a high-quality juicer. Best served immediately!

Ginger Greens Juice Servings: 1 Cook time: 5-10 minutes

• 1 cup pineapple cubes
• 1 apple, sliced
• 1-inch knob of ginger, rinsed, peeled and chopped
• 3 cups kale, rinsed and roughly chopped or ripped
• 5 cups Swiss chard, rinsed and roughly chopped or ripped

Juice all ingredients in a high-quality juicer. Best served immediately!

Zesty Beet Juice Servings: 1 Cook time: 5-10 minutes

• 1 grapefruit, peeled and sliced
• 1 apple, washed and sliced
• 1 whole beet, and leaves if you have them, washed and sliced
• 1-inch knob of ginger, rinsed, peeled and chopped

Juice all ingredients in a high-quality juicer. Best served immediately!

Protein Power Smoothie Serving: 1 Cook time: 5 minutes

• 1 scoop protein powder
• 1 tablespoon ground flaxseed
• 1/2 banana
• 1 kiwi, peeled
• 1/2 teaspoon cinnamon
• Pinch of cardamom
• Non-dairy milk or water, enough to achieve desired consistency

Blend all ingredients in a high-powered blender until completely smooth. Best served immediately!

ProLon� Fasting Mimicking Diet

Balanced methylation support can be achieved through proper nutrition. The ProLon� fasting mimicking diet offers a 5-day meal program which has been individually packed and labeled to serve the foods you need for the FMD in precise quantities and combinations. The meal program is made up of ready-to-eat or easy-to-prepare, plant-based foods, including bars, soups, snacks, supplements, a drink concentrate, and teas. The products are scientifically formulated and great tasting. Before starting the ProLon� fasting mimicking diet, 5-day meal program, please make sure to talk to a healthcare professional to find out if the FMD is right for you. The ProLon� fasting mimicking diet can help promote methylation support, among a variety of other healthy benefits.

Many doctors and functional medicine practitioners can recommend nutritional advice and/or guidelines to help improve DNA methylation. Proper nutrition and lifestyle habits can ultimately help improve DNA methylation. Nutrient deficiencies can ultimately cause DNA methylation deficits which may cause a variety of health issues, according to research studies. The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900�.

Curated by Dr. Alex Jimenez

Additional Topic Discussion:�Acute Back Pain

Back pain�is one of the most prevalent causes of disability and missed days at work worldwide. Back pain attributes to the second most common reason for doctor office visits, outnumbered only by upper-respiratory infections. Approximately 80 percent of the population will experience back pain at least once throughout their life. Your spine is a complex structure made up of bones, joints, ligaments, and muscles, among other soft tissues. Injuries and/or aggravated conditions, such as�herniated discs, can eventually lead to symptoms of back pain. Sports injuries or automobile accident injuries are often the most frequent cause of back pain, however, sometimes the simplest of movements can have painful results. Fortunately, alternative treatment options, such as chiropractic care, can help ease back pain through the use of spinal adjustments and manual manipulations, ultimately improving pain relief.

Formulas for Methylation Support

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