Dr. Jimenez, D.C., presents how to find the right diet for cardiometabolic syndrome in this 2-part series. Many environmental factors often play a role in our health and wellness. In today’s presentation, we continue discussing how genes play with the cardiometabolic diet. Part 1 looked at how every body type is different and how the cardiometabolic diet plays its role. We mention our patients to certified medical providers that provide available therapy treatments for individuals suffering from chronic conditions associated with metabolic connections. We encourage each patient when it is appropriate by referring them to associated medical providers based on their diagnosis or needs. We understand and accept that education is a marvelous way when asking our providers’ crucial questions at the patient’s request and acknowledgment. Dr. Alex Jimenez, D.C., uses this information as an educational service. Disclaimer
Omega-3s & Genes
Dr. Alex Jimenez, D.C., presents: We’ve found that fish oils or omega-3s can lower triglycerides, small-density LDL, and sometimes lower LDL and keep HDL regulated. But these studies were back when they were supplementing with more of an even DHA/EPA ratio. But that’s something to be observant of; the study showed that giving them fish oil lowers their small density LDL and triglycerides. They also found that if they gave them a lower fat food plan, and a lower fat diet, they found it lowered their LDL and small density LDL. A moderate fat diet reduced their LDL, but it increased their small density LDL. And they found that average alcohol consumption lowered their HDL and increased their LDL. So that’s not a good sign when that happens. So the opposite of what you want to occur with a moderate alcohol consumption diet or food plan.
So going back to APO-E4 in the body, how would this gene be affected when dealing with viral infections like herpes or cold sores? So research studies have revealed that APO-E4 and herpes simplex one viruses can affect the brain’s cerebral tissues. So the research also indicates that patients with APO-E4 are more susceptible to getting the herpes virus. And remember, herpes simplex one virus is what causes cold sores. What about HSV and dementia? How would that correlate with the body? The research indicates that HSV increases the risk of dementia. And what the thought is is that just like the herpes virus can come out and cause cold sores, it can internally manifest, and you can get these episodes where HSV becomes active in the brain, which can cause some of the pathogenesis of dementia or Alzheimer’s disease.
APO-E & Finding The Right Diet
Dr. Alex Jimenez, D.C., presents: And there was a study that showed that if you gave patients with dementia antivirals, it decreased the risk of getting dementia. So what do we do with the APO-E genotype? If you have APO-E2, APO-E3, or APO-E4, you can start them on the cardiometabolic food plan. If they’re on the SAD diet, the standard American diet, then putting them on the cardiometabolic food plan is just a good idea. It’s going to start shifting them in the right direction. What about additional consideration if they have APO-E3/4 and APO-E4/4? There are a couple of reasons you should jump in on this. They like it more when you customize a diet to a patient’s genetics. So if you can say, listen, we have your genes, and we know that you would do better if you had lower saturated fat, or if you don’t do so well on alcohol X, Y, or Z, it makes them pay attention more.
Because now it’s personalized. It’s not like, “Hey, everybody, just eat healthily.” It’s more personalized to your genetics. So, that would be a reason to start this from the get-go. But get them on the cardiometabolic food plan, and they should begin to feel better. But we would start by putting the whole thing in perspective that this APO-E3/4 and APO-E4/4 is not a death sentence. It’s a clue of how you respond to your environment and what we need to watch out for. It does not mean that you are going to get Alzheimer’s. The majority of people with Alzheimer’s do not have APO-E4. You have a higher risk of getting Alzheimer’s if you have APO-E4. And that’s where functional medicine comes in to risk-stratify them.
Finding The Right Diet For You
Dr. Alex Jimenez, D.C., presents: We recommend a lower simple carbohydrate diet or a higher glycemic index diet. And diet and food plan interchangeably, but patients call it a food plan because diet has negative connotations. So we avoid the word diet because when people hear or speak it, some people are triggered by it. You have people with food disorders and people with bad experiences with diets. A lower fat and a lower saturated fat food plan or recommendation is something to consider and be more aggressive with omega-3s. And if you start giving omega-3s to the patients, it is best to check their omega-3 levels and see if they begin to fluctuate. If they start shifting for the better, then we strongly advise against alcohol and monitor these patients for cognitive decline; there are different tools that you can use.
When it comes to omega-3s, it is best to do a cognitive test to keep an eye on their mentation. So if it starts to decline, you’re jumping in way before you have a major problem. And because of the issue of them not being able to deal with viral infections like herpes. And because the herpes virus may play a role in getting dementia, you may consider lysine supplementation. Arginine can deplete lysine. So if you end up eating a lot of pumpkin seeds and a lot of almonds and whatnot that have higher amounts of arginine, you can counteract that with lysine. And the research suggested that you need about two grams of lysine daily. But remember, every patient is different, so don’t just throw everybody on lysine if they have APO-E3/4, APO-E4, or APO-E44 3 but just something to consider.
So final thoughts on APO-E and nutrition. There are many pieces to the puzzle. Do not be dogmatic and say you have these genes, so you must do this. Just realize there are so many different genes, so many other variabilities, and recognize that it’s not that race can have something to do with how APO-E is affected. For example, they did a study that found that people in Nigeria had higher amounts of APO-E4, and the APO-E4 four did not increase their risk of dementia. So there are other pieces of the puzzle, monitor biomarkers and continue to adjust the plan. Next, we will discuss dealing with people with high triglycerides and high LDL.
What To Do With Abnormal Lipids?
Dr. Alex Jimenez, D.C., presents: So how do you take the abnormal lipid findings that you see on your profiles of your patients, those biomarkers, as all of us check? And how do you adjust the cardiometabolic food plan? What of the highlights of a cardiometabolic food plan that you will do for your patient in response to their lipids? Let’s first review a few things we know about how to modulate the diet’s lipids. First, we know that if you go from a standard American diet to the cardiometabolic food plan. You remove the trans fatty acids, and if you remove the trans fatty acids, then you will see a decrease in LDL cholesterol triglycerides. You’ll get an improvement in HDL; to say it another way, if your diet is high in trans fatty acids, you’ll have a higher LDL you have, you’ll have more elevated triglycerides, and you’ll have lower HDL.
How To Modulate Your Diet
Dr. Alex Jimenez, D.C., presents: What else about modulating the diet? If you have longer chain fatty acids that are not polyunsaturated, you’ll have an increase in your LDL and triglycerides and an increase or no change in your HDL cholesterol. On the other hand, we focus a lot on the shorter chain fatty acids and functional medicine. So if you have shorter chain fatty acids that are less than ten carbons, you’ll have lower LDL cholesterol triglycerides and increased HDL. So you can see with the cardiometabolic food plan, by addressing with the patient, their fat source, you can begin to impact LDL cholesterol without anti-triglycerides, without any other modulation other than dietary habit. And then finally, we know the data early and some of the most recent meta-analyses of changing simple sugars in the diet.
We know that that can, in its own right, increase LDL cholesterol triglycerides, and you get a lowering of HDL. So let’s put this all in context. What do we want to do for our patients to decrease the risk of coronary artery disease or atherosclerosis fat disease? We want their LDL cholesterol to be in a lower range. We do not wish for that LDL to be oxidized. We want the HDL to be higher. And if we can get triglycerides down through dietary change, then that gives us a clue that they might not be dysfunctional in the insulin metabolism. Then finally, with omega-3 fatty acids or adding omega-3 fatty acids or mono-concentrated fatty acids, we’ll lower LDL cholesterol triglycerides, and we’ll get an increase in HDL cholesterol. This is associated with a reduction in cardiovascular risk independent of lipid levels.
Conclusion
Dr. Alex Jimenez, D.C., presents: How is that affecting the body? It is because you have inflammatory drivers independent of your serum lipids that will increase your risk of atherosclerosis disease. It comes to saturated fat and fat content. Balancing the proteins, and the fat, you don’t have as much oxidative stress associated with inflammation after a meal. Thus, even if you have an elevated LDL level, you have less chance of having an increased oxidized LDL. Incorporating fibrous foods, antioxidants, lean meats, dark leafy greens, and supplements into a healthy diet can help lower LDL and fatty acids in the body and reduce all these comorbidities causing issues to your health and wellness.
So, those are just some tips and tricks for diet prescription to reduce cardiometabolic syndrome. And we encourage your patients to add more greens, legumes, nuts, and seeds, making the plant-based diet a mainstay for their heart health.
Dr. Jimenez, D.C., presents how chronic metabolic connections like inflammation and insulin resistance are causing a chain reaction in the body in this 2-part series. Many factors often play a role in our health and wellness. In today’s presentation, we will continue on how these chronic metabolic diseases affect the vital organs and organ systems. It can lead to overlapping risk factors associated with pain-like symptoms in the muscles, joints, and vital organs. Part 1 examined how overlapping risk profiles like insulin resistance and inflammation affect the body and cause muscle and joints pain-like symptoms. We mention our patients to certified medical providers that provide available therapy treatments for individuals suffering from chronic conditions associated with metabolic connections. We encourage each patient when it is appropriate by referring them to associated medical providers based on their diagnosis or needs. We understand and accept that education is a marvelous way when asking our providers’ crucial questions at the patient’s request and acknowledgment. Dr. Alex Jimenez, D.C., uses this information as an educational service. Disclaimer
How The Liver Associated With Metabolic Diseases
So we can look to the liver to find earlier cues of cardiovascular risk. How can we do that? Well, let’s understand some liver biochemistry. So in a healthy liver cell hepatocyte, when you have increased insulin being secreted because there was a meal that required glucose to be absorbed, what you expect if the insulin receptor works is that the glucose would go in. Then the glucose would get oxidized and turned into energy. But here’s the problem. When the hepatocyte has insulin receptors that don’t work, you’ve got that insulin on the outside, and the glucose never made it in. But what also happens on the inside of the hepatocyte is it was assumed that the glucose was going to get in. So what it does is it turns off fatty acid oxidation, thinking, “Guys, we don’t need to burn our fatty acids. We’ve got some glucose coming in.”
So when the glucose is not there, and you’re not burning off fatty acids, very common for people to feel fatigued because nothing is burning for energy. But here is the secondary sequela; where are all those fatty acids going, right? Well, the liver may try to repackage them as triglycerides. Sometimes, they stay in the hepatocyte or get shifted out of the liver into the bloodstream as VLDL or very low-density lipoprotein. You might see it as a high triglyceride shift in a standard lipid panel. So, when all of us are talking about getting a triglyceride level to around 70 as your 8+ goal, when I start seeing triglycerides rising, we wait until they’re 150, even though that’s the cutoff for our labs. When we see it at 150, we know they are shunting triglycerides out of the liver.
So that will happen many times before we find impaired fasting glucose. So look at your triglycerides, fasting triglycerides, as an emerging or early biomarker of insulin dysfunction. So this is another diagram that says that if the triglycerides are being created because the fatty acids are being oxidized, they can stay in the liver. Then that makes steatosis or the fatty liver, or they can be pushed out, and they turn into lipoproteins. We’re going to talk about that in just a second. The body is like, “What are we going to do with these fatty acids?” We can’t try to shove them into places because nobody wants them. To that point, the liver is like, “I don’t want them, but I will keep some with me.” Or the liver would have these fatty acids transported and stuck to the blood vessel walls.
And then the blood vessels and arteries are like, “Well, I don’t want them; I’ll put them underneath my endothelium.” And so that’s how you get atherogenesis. The muscles are like, “I don’t want them, but I’ll take some.” That’s how you get the fatty streaks in your muscles. So when the liver is getting bogged down with steatosis, inflammation occurs in the body and produces this feed-forward cycle inside the hepatocyte, damaging the liver. You’re getting cellular death; you’re getting fibrosis, which is just an extension of what happens when we don’t address the core issues for fatty liver: inflammation and insulin resistance. So, we look for subtle rises in AST, ALT, and GGT; remember that it is a liver-based enzyme.
Hormone Enzymes & Inflammation
GGT enzymes in the liver are smoke detectors and tell us how much oxidative stress is going on. Will we look at HSCRP and APOB to see the output of this liver? Is it starting to dump excess fatty acids through VLDL, APOB, or triglycerides? And how it picks that is just genetics, honestly. So I look for liver markers to tell me what’s going on in the liver as a sign of what’s happening everywhere. Because that might be the genetic weak spot of the person, some people are genetically vulnerable just in terms of their lipid profiles. To that point, we can look for something called metabolic dyslipidemia. You know this as high triglycerides and low HDL. You can specifically look for a ratio; an optimal balance is three and lower. It starts going from three to five and then five to eight, like eight is almost pathognomonic of insulin resistance. You’re just reaching becoming more and more insulin resistant.
As the number increases for that trig over HDL ratio, that is a simple, easy way to screen for insulin resistance. Now some people look 3.0 on this but still have insulin resistance. So there are other tests you do. This is a way to find those who show insulin resistance through lipids. And remember, everybody is different. Women with PCOS could have amazing lipids but could express an increase or decrease of hormones associated with insulin, estrogen, and inflammation. So look for something other than one test or ratio to indicate whether they’ve got it. You’re looking to see what could be the place where we will find the clue.
So let’s use the word healthy. A healthy person has VLDL that looks to be a healthy normal size in their bodies, and they have normal LDL and HDL. But now look at what happens when you get insulin resistance. These VLDL ls start to pump up with triglycerides. That’s why they’re fattening up. It’s lipotoxicity. So if you start looking at the VLDL three numbers in a lipoprotein profile, you’ll see that that number is creeping up, and there are more of them, and their size is bigger. Now with LDL, what happens is that the cholesterol amount within the top and the bottom is the same. If I pop all these water balloons, it’s the same amount of LDL cholesterol. However, that amount of LDL cholesterol in insulin resistance is repackaged in small dense LDL.
How Does Functional Medicine Play Its Part?
Now we understand that there may be some of you who cannot or do not have access to this testing, or your patients cannot afford it, and that’s why we answered the questions and looked for other clues of insulin resistance and treat the root cause that is affecting the body. Look for signs of inflammation and other overlapping profiles of insulin resistance. The particle number is higher when they’re insulin resistance. So cholesterol is the same, whereas the particle number is more elevated, and small dense LDL is more atherogenic. Treat it because whether or not you have access to knowing the LDL particle, there should be something in your head that says, “Man, even though this person’s LDL cholesterol looks good, they have tons of inflammation and insulin resistance; I can’t be sure that they don’t have higher particle number.” You might assume that they do this just to be safe.
The other thing that happens in insulin resistance is that the HDL or the healthy cholesterol tends to become small. So that’s not very good because the efflux capacity of HDL is lessened when it’s smaller. So we like the larger HDL, if you will. Access to these tests would give you a solid indication of what’s going on with your patient from a cardiometabolic perspective.
When it comes to these tests, it is important to utilize them to determine the patient’s timeline when they have inflammation or insulin resistance in their bodies, affecting their quality of life. However, many people would often express that these tests are expensive and would go with the gold standard of testing for affordability and be able to decide if it is worth it to better their health and wellness.
Look For Cardiometabolic Risk Patterns
So when it comes to cardiometabolic risk factor patterns, we look at the insulin aspect and how it correlates with mitochondrial dysfunction associated with insulin resistance and inflammation. A research article mentions how two mitochondrial dysfunctions can affect the body. Okay, let’s talk about the first issue, which is the quantity issue. One could be endotoxins that we encounter in our environment, or two; it can be genetically passed along from generation to generation. So the two types could indicate that you don’t have enough mitochondria. So that’s a quantity issue. The other problem is it’s a quality issue. You got plenty of them; they don’t work well, so they don’t have high output or at least normal results. Now how does this play out in the body? So out in the periphery, your muscles, adipocytes, and liver, you have mitochondria in those cells, and it’s their job to energize that lock and jiggle. So if your mitochondria are in the right number, you’ve got plenty to energize the insulin cascade lock and jiggle.
Interesting, right? So here it is in summary, if you don’t have enough mitochondria, which is the problem in the periphery, you get insulin resistance because the lock and jiggle aren’t working well. But if you do not have the mitochondria working well in the pancreas, especially in the beta cell, you don’t secrete insulin. So you still get hyperglycemia; you don’t have high insulin state. When this happens, we know your brain should be hurting, but hopefully, it will come together slowly.
Another article mentions that it connects mitochondrial dysfunction with type two diabetes, and poor maternal nutrition can prime it. This one talks about how fatty liver is associated with lipotoxicity, right? That’s that increased fatty acid, and oxidative stress, which, remember, is the byproduct of inflammation. ATP depletion and mitochondrial dysfunction. When this happens, it can affect the liver, which then turns into the fatty liver, and can also be associated with gut dysfunction, which leads to chronic inflammation, elevated insulin resistance, mitochondrial dysfunction, and many more. These chronic metabolic diseases are connected, and there are ways to reduce these symptoms from affecting the body.
Conclusion
When having a conversation with their doctors, many patients know that the same drivers affect a whole host of other phenotypes, all commonly rooted in inflammation, insulin, and toxicity. So when many people realize these factors are the root cause, doctors will work with many associated medical providers to develop personalized functional treatment plans. So remember, you always have to use the timeline and the matrix to kind of help you know where do you start with this patient, and for some people, it might be you’re just going to tweak a little bit of lifestyle because all they’re working on is changing their body count. So it’s one of the blessings of functional medicine that we were able to turn off the inflammation in the gut, which helps reduce the toxic impact burdening the liver. It also allows the individual to find out what works or doesn’t work with their bodies and take these small steps to improve their health.
We hope you have fresh eyes about inflammation, insulin, and toxicity and how it is at the root of so many conditions that your patients are facing. And how through very simple and effective lifestyle and nutraceutical interventions, you can change that signaling and change the course of their symptoms today and the risks they have tomorrow.
Dr. Jimenez, D.C., presents how to prevent atherosclerosis through various therapies that can help reduce the effects of cardiovascular diseases. By understanding the risk factors causing these issues, many specialists associated with cardiovascular disorders can develop a solution to minimize these symptoms that correlate with the vital organs and muscles with a personalized treatment plan. We acknowledge patients to certified providers that provide treatment options for cardiovascular disorders that can restore body functionality and improve a person’s health. We assess each individual and their symptoms by entrusting them to our associated medical providers based on their diagnosis results for a better understanding. We recognize that education is a tremendous way to ask our providers questions about the patient’s knowledge and symptoms. Dr. Jimenez, D.C., implements this information as an educational service. Disclaimer
The Cardiovascular System & Atherosclerosis
Dr. Alex Jimenez, D.C., presents: When the body deals with various issues causing muscle and joint pain, it could be due to overlapping risk profiles affecting the cardiovascular system. In a normal functioning body, the cardiovascular system works with different systems, including the musculoskeletal system, the pulmonary system, the endocrine system, the central nervous system, and the gut system. The heart is one of the main vital organs in the cardiovascular system that supplies oxygen-riched blood to the different muscles, tissues, and organs to function properly. The oxygen-rich blood also carries other items to circulate in the body, like hormones, protein, and nutrients, to be used later. However, when environmental factors start to disrupt the body, they can affect the cardiovascular system and can do serious damage. To that point, it can develop cardiovascular diseases over time and cause body pain. Many studies and research have shown cardiovascular diseases are still the number one in the world that causes mortality and morbidity in the body. They can cause other issues that can affect the body.
One of the cardiovascular diseases that can lead to heart dysfunction is atherosclerosis. Atherosclerosis is a buildup of plaque (fats, cholesterol, and other hard, sticky substances) that builds up over time along the artery walls that can slow down the blood flow, causing less circulation in the arteries. When the circulation becomes obstructed, it can lead to ischemia associated with a blood clot due to the different body areas not getting enough blood and oxygen to function properly.
Inflammation Associated With Atherosclerosis
Dr. Alex Jimenez, D.C., presents: When this happens, there can be an imbalance of LDLs (low-density lipoproteins) which can then develop various symptoms over time that can lead to muscle and joint pain. Some of the most common underlying reasons that can cause LDL imbalances associated with atherosclerosis could include the following:
Chronic inflammation
Immune dysfunction
Oxidative stress in the vascular system
Poor diet
Tobacco exposure
Genetics
Pre-existing cardiovascular disease
When various disruptors can damage LDL, it can become oxidized over time, damage the cardiovascular endothelium wall, and cause macrophage and platelet activation. To that point, once the macrophages start to eat, they form into foam cells and then explode and release peroxidation, which means that they damage the lining of the blood vessel.
Looking closer at the oxidized LDL, it can biotransform into pro-inflammatory markers and is correlated with vascular inflammation. When dealing with vascular inflammation, the body can develop metabolic endotoxemia. Metabolic endotoxemia is where LPS (lipopolysaccharides) levels elevate even though there is a presence of infections in the body. To that point, it can correlate to gut dysbiosis and chronic inflammatory diseases to stimulate the immune system to increase NFkB inflammatory cytokines and cause muscle and joint pain.
When there is an increase in inflammation due to atherosclerosis or any cardiovascular disease an individual may have, the signs and symptoms can vary depending on their environment. Excessive weight gain, hypertension, increased oxidative stress, high triglycerides, low HDLs, etc., can affect the body and make it dysfunctional. These mechanic factors can influence dysbiosis in the cardiovascular and gut systems, leading to chronic conditions like IBS, metabolic syndrome, and cardiovascular diseases.
Treatments To Lower Inflammation
Dr. Alex Jimenez, D.C., presents: So what can we do to reduce the inflammation associated with atherosclerosis causing muscle and joint pain? Well, one of the ways that many people can do this is by eating less refined carbohydrates, and high sugar can lower high glycemic levels in the body can reduce the risk of cardiovascular diseases. Another way is to try the Mediterranean diet, which includes lean proteins, nuts, extra virgin olive oil, heart-healthy vegetables, fresh fruits, and whole grains to reduce inflammatory markers from proceeding further to causing issues in the body. Even supplements and nutraceuticals like glutathione and omega-3s can reduce chronic inflammation and cardiovascular disease complications by enhancing their antioxidant properties to preserve redox homeostasis while regulating oxidative stress in the body.
Another way people can prevent atherosclerosis is by exercising regularly. An exercise routine is an excellent way to keep the heart pumping and allow the muscles to move. Any exercise like yoga, Crossfit, dancing, swimming, walking, and running will allow more oxygen intake to the lungs, allowing the heart to pump out more blood to allow more circulation to the various organs, muscles, and tissues. Plus, any exercise can reduce plaque buildup in the arteries and reduce inflammation in the muscles and joints affecting the body.
Chiropractic Care & Inflammation
Dr. Alex Jimenez, D.C., presents: And finally, treatments like chiropractic care can help restore functionality to the body through spinal manipulation. Now, how does chiropractic care correlate with cardiovascular diseases like atherosclerosis? When the body is dealing with inflammation and chronic stress associated with atherosclerosis, the decrease in blood circulation can cause internal organ dysfunction and disrupt the transmitted signals to reach the brain. So when the transmitted signals become blocked, it can cause spinal subluxation to the spine and invokes pain in the upper, middle, and lower sections of the back, neck, hips, and shoulders. To that point, a chiropractor incorporates mechanical and manual manipulation to realign the spine and allow joint and muscle function back to the body. At the same time, chiropractic care can work with other associated medical providers to develop a personal treatment plan that allows the body to begin its recovery process.
Conclusion
Our goal is to reduce inflammation and oxidative stress in the body to dampen the effects of cardiovascular diseases associated with pain. Covering some of the different ways to prevent atherosclerosis from affecting the cardiovascular system in the body can help the vital organs and muscles from producing more inflammation associated with pain. Incorporating heart-healthy and anti-inflammatory food, taking supplements, exercising, and going to treatments can make big changes to the body. The process may be tedious, but the results will slowly improve the body’s functionality and help the individual stay on the path of health and wellness.
Dr. Jimenez, D.C., presents how to reverse dyslipidemia and atherosclerosis through various therapies that can help the body function. By understanding the risk factors causing these issues, many specialists associated with these cardiovascular risk factors can develop a solution to reduce these and other pre-existing symptoms that correlate with the vital organs and muscles. We acknowledge patients to certified providers that provide treatment options for cardiovascular disorders that can restore body functionality and improve a person’s health. We assess each individual and their symptoms by entrusting them to our associated medical providers based on their diagnosis results for a better understanding. We recognize that education is a tremendous way to ask our providers questions that apply to the patient’s knowledge and symptoms. Dr. Jimenez, D.C., implements this information as an educational service. Disclaimer
Coming Up With A Treatment Plan
Dr. Alex Jimenez, D.C., presents: Today, we will look at how to reverse dyslipidemia and atherosclerosis functionally. In the previous article, we observed the risk factors of dyslipidemia and how it is associated with metabolic syndrome. Today’s objective looks at the emerging biomarkers that could lead to dyslipidemia and atherosclerosis. Looking at the fundamental guidelines from lifestyle, nutrition, physical activity, stress response, and incorporating supplements and nutraceuticals can help many individuals transform their health from a personal perspective. To that point, everyone is different, and their treatment plans are unique as they cater to each individual regarding health and wellness.
When it comes to functional medicine, tools like the Living Matrix and the IFM allow doctors to look at results that are being presented to the patient allowing them to see their cholesterol and the history that could lead to these cardiovascular disorders. Some of the earlier studies would enable doctors to prescribe their patients to go through nutrient depletion from statin therapy to reduce the effects of cardiovascular diseases. Supplements like CoQ10, vitamin K2, omega-3 fatty acids, vitamin D, zinc, and copper are all heart-healthy supplements that can give an insight into what the individual is missing to prevent dyslipidemia and atherosclerosis. Another thing is that statin therapies could also note how the hormone levels are also being affected in the body as these cardiovascular risk factors can cause hormone levels to be lower than they are and can affect both men and women.
Cardiovascular Risk Factors & Treatments
Dr. Alex Jimenez, D.C., presents: Now, this can be a double edge sword because we know that erectile dysfunction is a vascular issue, and it allows blood flow to the reproductive system. So say, for example, if someone has poor endothelial function reduction in nitric oxide vascular disease, they will have erectile dysfunction. So when this happens, statin therapy can help the individual and improve endothelial function. Utilizing these therapies is important when dysfunction in the body can cause overlapping risk profiles to the cardiovascular system and disrupt hormone reproduction. Without these various treatments, it can lead to pain associated with these symptoms that make the body have an imbalance of hormones, high cholesterol, and other issues that affect the body. As stated earlier, everybody is different, and the treatment plans are unique as they cater to each individual.
How can we tell when a person is dealing with dyslipidemia and atherosclerosis? After the examination and listening to how the patient is doing, many doctors would combine the AAPIER and SBAR protocol to come up with a diagnosis and look at the risk factors that correlate with these disorders. When the body is dealing with various environmental factors like poor sleep quality, being under constant stress, eating food high in saturated fats, and not getting enough exercise, it can cause the body to develop high cholesterol that can lead to building up plaque in the artery walls, causing chest pain associated with the heart. This is known as somato-visceral referred pain, where the affected muscle is causing issues to the corresponding organs related to pain. Another thing is that these environmental risk factors could overlap with inflammation and cause muscle and joint pain, which can cause complaints of limited mobility and stiffness that can cause a person to feel tight and miserable.
Inflammation Is A Key Factor
Dr. Alex Jimenez, D.C., presents: Factoring inflammation as a key player affecting the body is the first step in functional medicine. When it comes to the body being in constant pain due to inflammation, chronic stress, dyslipidemia, or atherosclerosis, it can cause the brain to transmit signals through the spinal cord and cause the surrounding muscles to be sensitive. The inflammatory markers can cause many individuals to be easily confused as they think they are dealing with back pain instead of somato-visceral pain. This is because inflammation can be good or bad, depending on the severity. When the immune system begins to release inflammatory cytokines, despite no infections, bacteria, or viruses, into the cardiovascular, gut, and musculoskeletal systems, it can cause symptoms of swelling, pain, redness, and heat that can affect the corresponding organs. So inflammation affects the heart; it can cause overlapping symptoms of shortness of breath, fluid buildup, and mimic chest pains. At the same time, inflammation in the gut can lead to unwanted factors that can cause harmful changes that can impair the homeostatic mechanism and activate multiple pathways that can trigger cardiovascular disease risk factors like atherosclerosis and dyslipidemia.
Now how would atherosclerosis be correlated with the heart? When the body deals with factors that can correlate with inflammation, many factors like high blood pressure or plaque buildup cause a blockage in the arteries, which can cause blood flow reduction to the heart for circulation. When this happens, it can lead to cardiovascular disease associated with chest pains. In functional medicine, figuring out where the inflammatory effects are coming from, which is most likely in the gut, can help many individuals to reduce and reverse dyslipidemia and atherosclerosis.
Reducing Cardiovascular Risk Factors
Dr. Alex Jimenez, D.C., presents: When it comes to reducing the development of dyslipidemia and atherosclerosis, various ways can help protect vital organs and reduce the inflammatory effects in the musculoskeletal system. One of the treatments that functional medicine corresponds with is chiropractic treatment. When it comes to the organs and spinal nerves in the body, there is a connection, as all internal organs are connected through the spinal cord that sends signals to the brain. When the transmitted signals are blocked or interrupted by risk factors that have entered the body, the vital organs can not function properly. So how would chiropractic treatment help with this? A chiropractor would use manual and mechanized manipulation to realign the spine from subluxation. This will allow the blockage to interrupt the transmitted signals to function properly and restore joint function while preventing degeneration, slowing the disease’s progress in the bones, muscles, and organs.
Another way to reduce inflammatory effects in the body is by incorporating heart and gut-healthy foods that can lower inflammation and improve gut microbiome health. Eating nutritious foods that are rich in prebiotics, have anti-inflammatory properties, and have soluble fibers can help the body turn them into SCFAs (short-chain fatty acids) that allow the large intestines to create more energy for the body. Incorporating these various ways as part of the treatment plan for individuals dealing with dyslipidemia or atherosclerosis can help reverse the effects slowly.
Conclusion
Combining heart-healthy foods, exercising regularly, and changing lifestyle habits can provide amazing results when these small changes are gradually incorporated. This will allow the person to see what works and what doesn’t while constantly communicating with their medical providers to ensure they get the amazing benefits that will improve their health and wellness.
Dr. Jimenez, D.C., presents how dyslipidemia can increase the chances of various issues associated with multiple risk factors that can cause muscle and joint pain. By understanding where these issues affect the body, many specialists associated with dyslipidemia can come up with a solution to reduce dyslipidemia symptoms and other pre-existing symptoms that correlate with high cholesterol. We acknowledge patients to certified providers that provide treatment options for dyslipidemia that can restore body functionality and improve a person’s health. We assess each individual and their symptoms by entrusting them to our associated medical providers based on their diagnosis results for a better understanding. We recognize that education is a tremendous way to ask our providers questions that apply to the patient’s knowledge and symptoms. Dr. Jimenez, D.C., implements this information as an educational service. Disclaimer
The Risk Factors Of Dyslipidemia
Dr. Alex Jimenez, D.C., presents: Today we will look at the guidelines and the risk factors of dyslipidemia. When specialists utilize these guidelines that involve lipid production in the patient’s body, they use these guidelines to emphasize lifestyle therapies that can encourage more patient involvement and decision-making regarding their health. When an issue involves an increase or decrease in lipid production in the body, it can be due to lifestyle choices that can affect anyone and correlate to metabolic syndrome. In functional medicine, it is important to look, follow, and know these guidelines to understand better what is going on with the patients and come up with a treatment plan that can help reduce the risk factors of dyslipidemia and treat the symptoms associated with these risk factors.
Regarding these guidelines, doctors work with associated medical specialists that look into lipid production and develop a personalized list for the patients that shows the risk-enhancing factors causing dyslipidemia associated with cardiovascular diseases causing metabolic syndrome. Dyslipidemia is when an imbalance of lipid production in the body causes an increase in high cholesterol due to various factors that can lead to cardiovascular diseases. To that point, when a patient is dealing with high cholesterol due to a sedentary lifestyle or being constantly stressed, it can lead to an imbalance of lipid production and cause doctors to not just look at the standard lipid panels but also figure out how to come up with a treatment plan for their patients to regulate their lipid production.
How To Look For The Risk Factors Of Dyslipidemia?
Dr. Alex Jimenez, D.C., presents: So when it comes to looking at the risk factors that are developing dyslipidemia, functional medicine allows doctors to look at advanced lipid tests and evaluate the risk factors causing dyslipidemia. The evaluations of these tests find various risk factors that conventional medicine would not see, and it shows patients the importance of these results and gets their attention. To that point, many risk factors can enhance the progress of dyslipidemia. Risk factors include:
Having a family history of premature atherosclerotic cardiovascular diseases (ASCVD).
High levels of lipoprotein and triglycerides.
Excessive sedentary lifestyle.
Lack of physical activity.
Having pre-existing chronic inflammatory disorders that can cause hypersensitivity to the body.
All these risk factors can cause dyslipidemia to develop and can even overlap risk factors related to metabolic syndrome that can cause muscle and joint pain. Now how is metabolic syndrome associated with dyslipidemia?
Metabolic Syndrome & Dyslipidemia
Dr. Alex Jimenez, D.C., presents: Metabolic syndrome is a cluster of disorders that could be associated with dyslipidemia, as it can cause a person to feel miserable and affect their quality of life. When individuals have high cholesterol due to physical inactivity, not consuming lots of healthy fruits, vegetables, protein, and whole grains, smoking, or being in constant stress, it can affect the body both inside and out as it can cause a person to have imbalances of lipid and hormone function. When these imbalances affect the body, they can affect the individual’s mentality, bring down their energy to feel sluggish, and cause inflammatory issues in their joints and muscles that can lead to various injuries and diseases.
An example would be an individual who comes in dealing with back pain associated with obesity and has been dealing with high blood pressure and high cholesterol. When that person is being examined by their doctor, their results show an imbalance of how much their body produces lipids. To that point, many individuals are unaware that they have dyslipidemia unless they have a routine blood test and if it has gone severe. Other symptoms that dyslipidemia can cause in the body include:
Leg pain
Chest pain and tightness
Pain in the neck, jaw, shoulders, and back
Heart palpitations
Sleep problems
Leg swelling
If it is not treated right away, it can lead to more issues that can cause pain to the body and leave them feeling hopeless. When these unwanted symptoms and pathogens start to affect the body, it can cause the vital organs that monitor lipid production to be dysfunctional and cause chronic symptoms to rise over time.
Treatments & Guidelines For Dyslipidemia
Dr. Alex Jimenez, D.C., presents: By looking at the guidelines, we can assess the situation that the patient is dealing with, come up with an evaluation of how to reduce these risk factors that are causing dysfunction in the patient’s body, and come up with a personalized treatment plan that encourages the patient to participate in and work with other associated medical providers to ensure health and wellness to the person. All is not lost, as there are ways to reduce dyslipidemia associated with metabolic syndrome.
Treatments like chiropractic care can help restore the body’s systems through spinal manipulation in the cervical, thoracic, and lumbar regions to reduce stiffness and restore mobility to the person. An anti-inflammatory diet and exercise can help lower inflammatory effects and lower the high cholesterol the person is dealing with. And finally, exercise can help reduce stress and improve the range of motion of the body’s joints and muscles. All these treatments work together regarding a person’s health and wellness, as the body is a complex machine. The combination of functional medicine and chiropractic care can allow individuals to start making small changes in their lives to restore their health and become pain-free from metabolic syndrome associated with dyslipidemia. Remembering that it takes time for these treatments to show results of feeling good can make the journey to a healthier version of yourself worth it.
Dr. Alex Jimenez, D.C., presents the effects of metabolic syndrome that can disrupt the body’s functionality. Metabolic syndrome is a common disorder that can range from insulin resistance to inflammation and muscle pain. Considering how every person is different, we look at how metabolic syndrome is associated with insulin dysfunction and correlated with inflammation. We direct patients to certified providers that provide functional medicine treatments related to metabolic syndrome to restore body functionality. We acknowledge each patient and their symptoms by referring them to our associated medical providers based on their diagnosis for a better understanding of what they are dealing with. We understand that education is a tremendous way to ask our providers various questions that apply to the patient’s knowledge. Dr. Jimenez, D.C., applies this information as an educational service. Disclaimer
The Effects Of Metabolic Syndrome
Dr. Alex Jimenez, D.C., presents: Metabolic syndrome is a cluster of disorders that can affect the body and cause other issues to vital organs and muscle and joint functionality. Metabolic syndrome can also correlate with other conditions like diabetes and insulin resistance, which can cause referred pain in different body locations. For example, back pain associated with metabolic syndrome could overlap with obesity. So in the last article, we looked at how to recognize the causes of metabolic syndrome. In trying to understand how many people are prone to develop metabolic syndrome, we need to look at what they are eating, what kind of lifestyle they have, and if they have any pre-existing conditions. All these matters when they undergo an examination with their primary doctor.
Another thing to look into when diagnosing patients for metabolic syndrome is by looking at their genes. Whether it is a person’s lifestyle or environment, looking at a person’s genes, you will get a certain phenotype in the DNA sequence. To that point, if someone has an inflammatory lifestyle combined with a unique genetic code, functional medicine doctors can identify a bunch of comorbidities affecting the individual. With this information, doctors can inform their patients that if they don’t make small lifestyle changes, they could be at risk of developing overlapping conditions that can affect their bodies and invoke pain in the muscles, organs, and joints.
Functional Medicine & Metabolic Syndrome
Dr. Alex Jimenez, D.C., presents: That’s what the functional medicine conversation is about because we are trying to catch the issue before microvascular and macrovascular complications even set in the body. Since metabolic syndrome is a cluster of disorders, can it potentially correlate with other problems like insulin dysfunction?
Well, it can. When the body doesn’t produce enough insulin to provide energy to the body, it can lead to chronic inflammation. So whether it’s a poor lifestyle, microbiome dysfunction, visceral adiposity, or constant stress, inflammation associated with insulin dysfunction can drive the HPA axis into overdrive. Sometimes it could be not inflammation based. It could be related to mitochondrial dysfunction. So by looking at the analysis of the person dealing with metabolic syndrome, you look at their timeline, lifestyle, and the clinical imbalances driving the inflammatory markers to affect the body. The data can also look for signs of mitochondrial insults and comorbidities that could create insulin dysfunction that can lead to the development of the metabolic syndrome. This information will give functional medicine doctors a sense of what they are genetically predisposed to in their bodies.
Everyone is different, and catering to unique treatment plans for them can provide lasting results in the future. So when it comes to the functional and conventional approaches to metabolic syndrome associated with other various disorders, it is important to compare and contrast both methods to determine what the patient should consider doing to regain their health and wellness. This could be from the treatments that can work for the individual, what kind of foods can reduce the inflammatory markers and regulate hormone production, or their physical activity level. To that point, we will treat the cause through various techniques beyond pharmaceuticals and surgery as much as possible and, simultaneously, meet the patients where they are because sometimes people do well with lifestyle intervention. In contrast, others with more risks need more screening time and diagnostic tests.
Insulin Dysfunction Associated With Inflammation
Dr. Alex Jimenez, D.C., presents: Our main goal is to detect insulin dysfunction associated with inflammation that correlates with early metabolic syndrome. The lab results from our associated medical providers can tell us a story of what the patient is going through and determine whether we need to either put in nutrients that the body needs to correct or take out toxins, let’s say, that are interfering with the ability of the body to self-correct insulin dysfunction. Because preventing these comorbidities associated with metabolic syndrome can help many individuals regain their health and wellness.
Since we all have different microbiomes, the beautiful thing about functional medicine is that it brings awareness that needs to be addressed when our bodies are dealing with inflammation and insulin dysfunction that causes us to respond and use that response as an understanding of our microbiome. It allows us to reduce the effects of many issues and symptoms associated with metabolic syndrome that we may not even know about if we left it untreated. By being aware of what is causing problems in our bodies, we can make small changes in our daily life to better ourselves and our health.
Conclusion
Dr. Alex Jimenez, D.C., presents: With that being said, as stated earlier, metabolic syndrome can be a cluster of conditions that includes inflammation, insulin resistance, obesity, and hormonal dysfunction that can develop into somato-visceral or visceral-somatic issues that affect the organs and muscle groups. When all these issues begin to affect the body, they can lead to pre-existing conditions that can lead to joint and muscle pain. Regarding health and wellness, treating the effects of metabolic syndrome can do wonders for the body, mind, and soul. Making small changes to a lifestyle can provide numerous positive results and can restore functionality to the body.
Dr. Alex Jimenez, D.C., presents how many people can recognize the cause of metabolic syndrome. Metabolic syndrome is a cluster of conditions ranging from insulin resistance to muscle and joint pain. Considering how every person is different, we look at how metabolic syndrome is associated with cardiovascular disorders. We refer patients to certified providers that provide cardiovascular treatments associated with metabolic syndrome to relieve issues affecting the body while ensuring optimal wellness for the patient through various treatments. We acknowledge each patient by referring them to our associated medical providers based on their diagnosis to understand better what they are dealing with appropriately. We understand that education is an excellent way to ask our providers various intricated questions to the patient’s knowledge. Dr. Jimenez, D.C., utilizes this information as an educational service. Disclaimer
What Is Metabolic Syndrome?
Dr. Alex Jimenez, D.C., presents: Today, we are going to start widening the lens on metabolic syndrome. From a functional medicine perspective, many didn’t always call it metabolic syndrome. Other terms used to describe the diagnosis were:
Dysmetabolic syndrome
Hypertriglyceridemic waist
Insulin resistance syndrome
Obesity syndrome
Syndrome X
Metabolic syndrome is a cluster of disorders that can affect an individual’s daily life and cause various issues that can cause the body to be dysfunctional. So in 2005, the ATP three guidelines told us that patients must meet three out of five criteria to get the diagnosis of metabolic syndrome. So these are around waist circumference, which is about visceral adiposity, blood pressure, blood glucose, triglycerides, and HDL. And then you see the cutoffs there. So in the International Diabetes Federation diagnosis criteria, notice that it’s required to have central obesity, but per ethnicity-specific cutoffs for waist circumference. So instead of three out of five, you have to have one, and then the other two out of four must be met. So you see the other ones the same as before, but they’re just compartmentalized differently in this diagnosis scheme. Now let’s talk about these ethnicity-specific cutoffs.
So if you are a standard corn-fed American, your waist circumference cutoff is 40 inches as a male and 35 inches as a female. Now, if you were from different parts of the world, the numbers for waist circumference are different whether the ethnicity is Asian, Hispanic, African, European, or Middle Eastern. By looking at the diagnosis of metabolic syndrome by looking more into the ethnicity-specific cutoffs, you can see that more people would start to meet the criteria for metabolic syndrome if doctors use the stringent ethnicity-specific standards to diagnose their patients for metabolic syndrome. Other diagnoses would also notice where the visceral adiposity is at during the cutoff and see additional hints of insulin resistance. Other factors besides insulin resistance can cause the body’s systems to be dysfunctional, which will drive the common risk factors to cause the pain associated with metabolic syndrome to affect the muscles and muscle groups. When the body becomes dysfunctional due to metabolic syndrome, it can also affect vital organ systems like the cardiovascular system. Now how does metabolic syndrome correlate with the cardiovascular system?
How Does Metabolic Syndrome Associated With Cardiovascular System?
Dr. Alex Jimenez, D.C., presents: If you look at how a person’s lifestyle habits affect their body, you can see that the data shows how metabolic factors contribute to total cardiometabolic risk. This information lets the doctors and patients know about their LDL cholesterol, BMIs, family history, and blood pressure. Suppose a person has pre-existing cardiovascular issues associated with metabolic syndrome. In that case, it is important to know if their glucose levels have elevated or dropped and to see how to control those risk factors associated with cardiometabolic syndrome. These are important risk factors that have to be brought up in a metabolic dysfunction conversation to have a better understanding.
Now there are ways to reduce the effects of metabolic syndrome associated with cardiovascular diseases. By expanding the data from the patient’s test results, we can look beyond the cardiometabolic risk; we can determine the causes that are the progression of these issues affecting the body. This can be numerous issues like how much exercise the person is doing, how they deal with stress and inflammation, and what foods they eat.
By recognizing these results, we can identify things beyond metabolic syndrome and figure out what other disorders are contributing to metabolic syndrome. Many doctors will inform their patients about how their insulin levels can become elevated, which can cause them to develop insulin resistance and lose their beta cells. When insulin resistance corresponds with metabolic syndrome, many people need to realize that their genes can also play into effect. Some people have genes that drive them with the same kind of lifestyle dysfunction, inflammation, dysfunction, and insulin resistance. Their genes will also equal blood pressure issues or crazy lipid disturbances. When cardiometabolic risk factors are contributing to underlying problems affecting the body, it is really important to have functional medicine be the main focus to figure out where the issues are causing dysfunction in the body.
Insulin Resistance & Metabolic Syndrome
Dr. Alex Jimenez, D.C., presents: So when it comes to insulin resistance, it is important to take note of the abnormal beta cell function in the body if the pancreas can’t produce enough insulin to be turned into glucose. When this happens, people will begin to have elevated glucose levels, and if it continues to rise at a certain point, they will already be prone to having type 2 diabetes. To that point, the body will have this relative insulin deficiency, causing the body’s receptors not to be as sticky and functional.
When enough insulin is circulating the body and doing its job, the blood glucose levels don’t hit the threshold to become diabetes. Now, suppose the body maintains normal beta cell function. In that case, however, the insulin receptors are not working, which allows the pancreas to start pumping out insulin to be able to keep up with this resistance, causing the individual to be at a compensatory high insulin state. By stabilizing insulin levels, many individuals can control how much glucose is in their bodies. However, suppose a person is prone to becoming diabetic. In that case, all that insulin is being pumped out is a massive system biology dysfunction signaling many other nondiabetic downstream diseases.
Conclusion
So insulin dysfunction can be associated with cardiovascular disease due to poor lifestyle choices, dietary habits, and physical activity. When dealing with metabolic syndrome associated with these risk factors, it can cause the body to be dysfunctional and cause pain in the organs, muscles, and joints. This can lead to obesity and diabetes if it is not handled properly. Getting a routine started can help lower insulin resistance by eating properly, getting adequate sleep, practicing mindfulness, and exercising can help improve the body and mind.
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