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A Look At Gut-Brain Dysbiosis & Chronic Inflammation

A Look At Gut-Brain Dysbiosis & Chronic Inflammation

Introduction

One of the unique features of the body is when the gut and nervous systems have this communication partnership where information is transported back and forth throughout the entire body. The data transmitted to the brain and the gut travels through the nerve roots spread throughout the muscles, tissues, and ligaments that control the motor-sensory functions of the body. When the nerve roots become damaged or when there are gut issues affecting the organs in the gut system or even neurological disorders can cause the body to become dysfunctional and result in other matters affecting the muscles in the legs, arms, back, and neck. Today’s article looks at the functionality of the gut-brain axis, how this connection helps the body, and how disorders like inflammation and gut dysbiosis cause problems to the body and the gut-brain axis. Refer patients to certified, skilled providers specializing in gut treatments for individuals that suffer from gut dysbiosis and chronic inflammation. We guide our patients by referring to our associated medical providers based on their examination when it’s appropriate. We find that education is critical for asking insightful questions to our providers. Dr. Alex Jimenez DC provides this information as an educational service only. Disclaimer

 

Can my insurance cover it? Yes, it may. If you are uncertain, here is the link to all the insurance providers we cover. If you have any questions or concerns, please call Dr. Jimenez at 915-850-0900.

The Functionality Of The Gut-Brain Axis

 

Have you been experiencing inflammation in your gut? How about feeling tired constantly throughout the entire day? Do any of your joints or muscles ache or feel stiff? Many of these are signs that the gut-brain axis is affected by common factors that the body has encountered. There is evidence that the bi-directional signaling between the gastrointestinal tract and the brain is connected with the vagus nerve. Research studies have mentioned that the vagus nerve is the modulator of the gut-brain axis and is considered the primary component in the parasympathetic nervous system that is vital for maintaining homeostasis in the body. The vagus nerve helps the body by overseeing every bodily function like heart rate, digestion responses, immune responses, and sending the brain information about the state of the inner organs. The vagus nerve is also involved in the etiology of several metabolic and mental dysfunctions/disorders that the body encounters that affect the muscles and internal organs. Additional research studies have shown that the vagus nerve has anti-inflammatory properties that are activated from the HPA axis and release the hormone cortisol in the body. The macrophages in the spleen make tumor necrosis factor (TNF) a potent inflammation-producing molecule when the vagus nerve is stimulating the TNF production in the spleen, causing it to decrease. At the same time, the survival portion increases in the body.

 

How Does The Gut-Brain Axis Help The Body?

With the bi-directional that the gut and brain have on the body, it is evident that environmental factors like oxidative stress, inflammation, and mood disorders cause changes in the glutamatergic pathways and neurotrophins in the body. Research studies have mentioned that the gut-brain axis helps influence the autonomic nervous system by activating the immune system. When the immune system is activated, the body can generally function like muscle endurance, provide microbiota-derived SCFAs to the blood-brain barrier, and regulate the body’s homeostasis. When the gut-brain axis starts to become dysfunctional, the immune system will begin to increase its production of cortisol which can cause muscle stiffness and spasms to affect the body. When there is inflammation in the gut system, it can cause the muscles in the body to become weak, and it can affect the spine causing low back pain issues to develop over time. Whenever the gut-brain axis is affected by environmental factors, the body will begin to start causing trouble with these symptoms and making the individual miserable.


The Microbiome Being Affected By Inflammation-Video

Are you experiencing muscle stiffness or weakness in your lower back, neck, or other body parts? Have you experienced mood swings or felt anxious constantly? Many of these symptoms you are experiencing are dysfunctional gut-brain axis affecting your body. The video above explained what happens when the gut microbiome is affected by inflammatory factors causing gut dysbiosis and neurological disorders. Research studies have mentioned that the composition between the gut and the brain as they communicate helps shape the body. When a person starts changing their dietary habits and lifestyle, their gut composition will not only be affected, but their nervous system begins to change too. Unwanted factors can cause many disturbances in the body and, if not treated right away, can develop into chronic issues that affect the joints, muscles, and tissues.


Inflammation And Gut-Brain Dysbiosis

 

When the gut-brain system is affected by unwanted factors, various symptoms will begin to rise in the body and start wreaking havoc on specific organs, tissues, muscles, and joints that need the gut-brain axis to keep the body functioning. Not only can inflammation cause these unwanted factors, but gut dysbiosis can also affect the T-cells in the immune system. Research studies have mentioned that when inflammatory markers start to translocate harmful bacteria across the gut-epithelial barrier to the blood-brain barrier, it can contribute to multiple sclerosis on the spine. Additional research studies have found that a stroke-induced gut dysfunction in the body allows the commensal bacteria to infect the peripheral tissue, causing infections like pneumonia and urinary tract infections. When individuals start to figure out what is causing their gut-brain axis to become dysfunctional, they can begin to heal their bodies.

 

Conclusion

The gut and nervous systems have a special bi-directional connection known as the gut-brain axis. The gut-brain axis helps the body function by metabolizing the immune system and regulating homeostasis with the vagus nerve. The vagus nerve is part of the parasympathetic nervous system that allows every bodily function like heart rate, digestion, and immune response while sending information about the state of the inner organs to the brain. The vagus nerve also makes sure that the inner organs are functioning correctly. When unwanted environmental factors like inflammation or gut dysbiosis start to affect the gut-brain axis, it can wreak havoc on the internal organs and cause the body to become dysfunctional. When people notice that their body becomes dysfunctional, they will find treatments available to relieve these issues in their bodies and continue on their health and wellness journey.

 

References

Appleton, Jeremy. “The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health.” Integrative Medicine (Encinitas, Calif.), InnoVision Health Media Inc., Aug. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6469458/.

Bonaz, Bruno, et al. “Vagus Nerve Stimulation at the Interface of Brain-Gut Interactions.” Cold Spring Harbor Perspectives in Medicine, Cold Spring Harbor Laboratory Press, 1 Aug. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6671930/.

Breit, Sigrid, et al. “Vagus Nerve as Modulator of the Brain-Gut Axis in Psychiatric and Inflammatory Disorders.” Frontiers in Psychiatry, Frontiers Media S.A., 13 Mar. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC5859128/.

Gwak, Min-Gyu, and Sun-Young Chang. “Gut-Brain Connection: Microbiome, Gut Barrier, and Environmental Sensors.” Immune Network, The Korean Association of Immunologists, 16 June 2021, www.ncbi.nlm.nih.gov/pmc/articles/PMC8263213/.

Günther, Claudia, et al. “The Gut-Brain Axis in Inflammatory Bowel Disease-Current and Future Perspectives.” International Journal of Molecular Sciences, MDPI, 18 Aug. 2021, www.ncbi.nlm.nih.gov/pmc/articles/PMC8396333/.

Stopińska, Katarzyna, et al. “The Microbiota-Gut-Brain Axis as a Key to Neuropsychiatric Disorders: A Mini Review.” Journal of Clinical Medicine, MDPI, 10 Oct. 2021, www.ncbi.nlm.nih.gov/pmc/articles/PMC8539144/.

Disclaimer

Beta-Glucan: The Modulator of Immune Health

Beta-Glucan: The Modulator of Immune Health

Do you feel:

  • Tired or sluggish?
  • Difficult, infrequent bowel movement?
  • Mental sluggish?
  • Alteration in the bowel regularity?
  • Edema and swelling in ankles and wrist?

If you are experiencing any of these situations, then it might be something that may be attacking your immune system. Why not try to add some beta-glucan into your diet and overall health.

Throughout the last several years, beta-glucans have been gaining much attention due to the emergence of medicinal mushrooms in Western cultures. Across the country, studies have found that beta-glucans have been ubiquitous in the health food stores due to their immunomodulatory properties and cancer-protective effects. Since edible fungi have been known as the main source for beta-glucans, surprisingly though beta-glucan can be presented in a variety of foods like oats, barley, seaweeds, and yeast. Beta-glucan can also be found in dietary supplements for the body to consume.

Beta-glucans

beta-glucan structure

Beta-glucan is technically a non-starch polysaccharide, a prebiotic fiber that is formed by ?-1,3 and 1,6 glycosidic bonds. With beta-glucan, it can possess numerous health benefits depending on the molecular structure of each type of bond. Studies have shown that beta-glucans that are found in cereal grains can help lower cholesterol levels and can effectively bind serum cholesterol. Beta-glucans can even play a beneficial role in obesity, metabolic disorders, and other chronic non-communicable diseases. Since beta-glucans are a prebiotic fiber, research shows that they can play a significant role in promoting a healthy microbiome in the body. It means that beta-glucan can stimulate the growth of beneficial bacteria species, mitigating pathogenic ones, and even modulating inflammation to optimize the gut environment in the body.

Beta-glucans for Immune Support

In a 2019 study, it stated that �the relationship between immunity and nutrition is considered to be completely interconnected.� More studies have shown that beta-glucan can act on several immune receptors that can stimulate immune cell activity. This includes T-cells, macrophages, neutrophils, monocytes, natural killer (NK) cells, and dendritic cells. One of the studies showed how beta-glucans could pose modulatory effects on both the innate and adaptable branches of the immune system. One of the protein receptors is known as dectin-1; this protein receptor is on the surface of macrophages and dendritic cells.

What dectin-1 can do is that they can initiate and regulate the innate immune response by insoluble binding ?-1,3, and 1,6 glucans, plus it has become essential for controlling infections in the body. While water-soluble ?-glucan can bind to the CR3 receptors, thus triggering the adaptive immune response to the body. With ?-glucans, they can enhance phagocytosis while also triggering the release of various interleukins and cytokines, thus possessing cytotoxic anti-cancer properties. Studies have shown that TNF-?, IFN-?, and NF-??, can help to support the regulation of the T-helper cell 1 and Th-2 balance for immunological homeostasis for the body. Surprisingly in other articles, they talked about how yeast-derived ?-1,3/1,6 glucan can be delivered as an oral supplement for the winter months. The article study showed how it demonstrates its protective effects against upper respiratory tract infections in the body. The study even showed how it could reduce the upper respiratory tract infection symptoms that are already in older adults that have been infected. Another study showed that ?-glucan have cytoprotective abilities from viral infections and provide immunomodulatory properties to the body and the immune system.

With the population of many individuals, it turns out that the elderly population can benefit from the ?-glucan compound. With this compound, everyone can have a healthy immune system, especially during the cold and flu season. Having a healthy immune system is important because that way, the body can protect itself from harmful pathogens through functional medicine, healthy nutritious food, and supplements. By using these options, the body can heal itself and can dampen the effects of cold and flu symptoms.

More Research on Beta-glucan

Research studies have shown that ?-1,3 glucan from the fungal cell wall is one of the key ingredients for vaccines. The research shows as well that ?-glucan can produce robust humoral and cellular immune responses for the body when it is exposed to antigens. What is interesting is that ?-glucan is known to exert antioxidant activities in the body. With their reactive oxygen species (ROS) scavenging abilities, they can exert the antioxidants into the circulatory system and the mucosal immune system. There is a study that shows that ?-glucan in barley can possess a higher total of antioxidants significantly at a better capacity than oats and yeast. The study showed that ?-glucan could be subdivided into two groups depending on whether specific receptors are involved or not. It also stated that ?-glucan could be validated as a functional food ingredient.

Conclusion

All in all, ?-glucan is an amazing non-starch polysaccharide prebiotic fiber that has amazing properties that can help the body. ?-glucan can be found in mushrooms and a variety of other foods like seaweed and oats. This compound can help boost up the body’s immune system and can dampen any harmful pathogens effects that the body has come in contact with. This compound�s beneficial properties are amazing for anyone that consumes it and even added it to their daily diet. Some products combined with ?-glucan can support the immune system with hypoallergenic nutrients and targets amino acids.

The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.


References:

Bacha, Umar, et al. �Nutraceutical, Anti-Inflammatory, and Immune Modulatory Effects of ?-Glucan Isolated from Yeast.� BioMed Research International, Hindawi, 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5587958/.

Chan, Godfrey Chi-Fung, et al. �The Effects of Beta-Glucan on Human Immune and Cancer Cells.� Journal of Hematology & Oncology, BioMed Central, 10 June 2009, www.ncbi.nlm.nih.gov/pmc/articles/PMC2704234/.

Fuller, Richard, et al. �Yeast-Derived ?-1,3/1,6 Glucan, Upper Respiratory Tract Infection and Innate Immunity in Older Adults.� Nutrition, Elsevier, 23 Mar. 2017, www.sciencedirect.com/science/article/abs/pii/S0899900717300539.

Jurgelewicz, Michael. �New Study Demonstrates Novel Yeast-Derived Beta-Glucan Provides Immunomodulatory Effects in Older Adults.� Designs for Health, 21 Oct. 2018, blog.designsforhealth.com/si-42214/new-study-demonstrates-zinc-supplementation-improves-clinical-outcomes-from-traumatic-brain-injury.

Levitz, Stuart M, et al. �Exploiting Fungal Cell Wall Components in Vaccines.� Seminars in Immunopathology, U.S. National Library of Medicine, Mar. 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC4329074/.

Nakashima, Ayaka, et al. �?-Glucan in Foods and Its Physiological Functions.� Euglena, Co., Ltd., 14 Aug. 2017.

Nakashima, Ayaka, et al. �?-Glucan in Foods and Its Physiological Functions.� Journal of Nutritional Science and Vitaminology, U.S. National Library of Medicine, 2018, www.ncbi.nlm.nih.gov/pubmed/29491277.

Team, DFH. �Modulators of Immune Health: Beta-Glucans.� Designs for Health, 26 Mar. 2020, blog.designsforhealth.com/node/1219.

Team, DFH. �Mushrooms for Nutritional Medicine.� Designs for Health, 14 Feb. 2019, blog.designsforhealth.com/node/952.

Vetvicka, Vaclav, et al. �Beta Glucan: Supplement or Drug? From Laboratory to Clinical Trials.� Molecules (Basel, Switzerland), MDPI, 30 Mar. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6479769/.


Modern Integrative Wellness- Esse Quam Videri

The University offers a wide variety of medical professions for functional and integrative medicine. Their goal is to inform individuals who want to make a difference in the functional medical fields with knowledgeable information that they can provide.

Astragalus and The Immune System

Astragalus and The Immune System

Do you feel:

  • Dizziness when standing up quickly?
  • A slow start in the morning?
  • Edema and swelling in ankles and wrist?
  • Muscle cramping?
  • Tired or sluggish?

If you are experiencing any of these situations, then there might be some dysfunction in your body�s system, including the immune system. Why not try the Chinese herb, astragalus to help alleviate the symptoms.

Astragalus

In traditional Chinese medicine, the herb astragalus has been used for thousands of years and has been known to strengthen chi or qi life force in the body. This herb has been known to be typically employed in conditions that are related to general weakness in the body like fatigue, anemia, a poor appetite, cardiovascular diseases, and other conditions that can weaken the body. Surprisingly though, astragalus can be used to optimize kidney health and, with the combination of ginseng and echinacea, can boost up the body’s immune system. There is a variety of astragalus that are native to Northeast Asia, and its roots need to be dried and powdered to be transformed to be consumed as a capsule or as a tea.

Astragalus Beneficial Properties

Studies have found that astragalus�s beneficial pharmacological effects might contain phytochemical components, which include a host of saponins polysaccharides and flavonoids that the body’s immune system needs to function correctly. Another study found that astragalus contains about twenty trace minerals that are highly important for the body. With astragalus extract, it has immune-modulating properties in vivo and in vitro in both animals and humans, and research shows that the herb stimulates and influences on the immune response cytokines while also leaving the inflammatory cytokines unaffected.

Some of the beneficial properties that astragalus can have on the body are still being researched; however, this Chinese herb can help the body to function correctly and are effective.

Improving the Immune System

493ss_thinkstock_rf_Immune_system_concept

Studies have shown that astragalus contains some beneficial plant compounds that may enhance the body’s immune system. Studies show that the primary role for the immune system is that it helps protect the body from foreign pathogens like harmful bacteria and viruses that can cause a person to be ill. Research has found out that there is some evidence that astragalus can increase the body�s production of white blood cells, which will help prevent illnesses from entering the body. In other research studies, it has been found that astragalus root has been known to help the body kill bacteria and viruses caused by infections. Even though the research may be limited, there are still studies that show that astragalus can fight off viral infections like the common cold and liver infections in the human body.

Improving the Heart Function

Research shows that astragalus may be able to improve heart function by widening the blood vessels and increasing the amount of blood that is being pumped from the heart. In a clinical research study, it showed that patients were given at least 2.25 grams of astragalus for two weeks and have experienced a more significant improvement in their heart function. In another study, it shows that astragalus may help reduce the symptoms of myocarditis, which is an inflammatory condition in the heart.

Improving Kidney Function

Astragalus can help support kidney health in the body by improving the blood flow to the kidneys and measuring the protein in the urine. A study has shown that proteinuria is a condition where there is an abnormal amount of protein that is found in urine, and it can be a sign that the kidneys are not functioning normally or may be damaged. Surprisingly, there was another study that showed that astragalus could improve proteinuria symptoms in individuals that have kidney disease. Studies have even found that astragalus may also help prevent infections for anyone who has a reduce kidney function and reducing the risk of a kidney disorder known as nephrotic syndrome.

Conclusion

Astragalus is a unique herb that can help the body’s immune system to function correctly. Even though there is a limited amount of research on this herb, but the beneficial properties it provides in the body are truly amazing. Astragalus can be consumed by capsules or even be brewed as a tea, so that way, people can enjoy the beneficial properties and that their body is performing excellently in health and wellness. Some products offer support to the body’s immune system and help target the amino acids that are intended to support the intestines while offering more support to the metabolic system.

The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.


References:

Block, Keith I, and Mark N Mead. �Immune System Effects of Echinacea, Ginseng, and Astragalus: a Review.� Integrative Cancer Therapies, U.S. National Library of Medicine, Sept. 2003, www.ncbi.nlm.nih.gov/pubmed/15035888.

Fu, Juan, et al. �Review of the Botanical Characteristics, Phytochemistry, and Pharmacology of Astragalus Membranaceus (Huangqi).� Phytotherapy Research: PTR, U.S. National Library of Medicine, Sept. 2014, www.ncbi.nlm.nih.gov/pubmed/25087616.

Gao, Xing-hua, et al. �Saponin Fraction from Astragalus Membranaceus Roots Protects Mice against Polymicrobial Sepsis Induced by Cecal Ligation and Puncture by Inhibiting Inflammation and Upregulating Protein C Pathway.� Journal of Natural Medicines, U.S. National Library of Medicine, Oct. 2009, www.ncbi.nlm.nih.gov/pubmed/19548065.

Meixner, Makayla. �Astragalus: An Ancient Root With Health Benefits.� Healthline, 31 Oct. 2018, www.healthline.com/nutrition/astragalus.

Nalbantsoy, Ay?e, et al. �Evaluation of the Immunomodulatory Properties in Mice and in Vitro Anti-Inflammatory Activity of Cycloartane Type Saponins from Astragalus Species.� Journal of Ethnopharmacology, U.S. National Library of Medicine, 31 Jan. 2012, www.ncbi.nlm.nih.gov/pubmed/22155389.

Peng, T Q, et al. �Effect and Mechanism of Astragalus Membranaceus on Coxsackie B3 Virus RNA in Mice.� Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine, U.S. National Library of Medicine, Nov. 1994, www.ncbi.nlm.nih.gov/pubmed/7703635.

Piao, Yuan-lin, and Xiao-chun Liang. �Astragalus Membranaceus Injection Combined with Conventional Treatment for Viral Myocarditis: a Systematic Review of Randomized Controlled Trials.� Chinese Journal of Integrative Medicine, U.S. National Library of Medicine, Oct. 2014, www.ncbi.nlm.nih.gov/pubmed/25098261.

Team, DFH. �Astragalus: Funny Name Serious Results.� Designs for Health, 9 Oct. 2018, blog.designsforhealth.com/astragalus-funny-name-serious-results.

Team, NCBI. �Astragalus Membranaceus. Monograph.� Alternative Medicine Review: a Journal of Clinical Therapeutic, U.S. National Library of Medicine, Feb. 2003, www.ncbi.nlm.nih.gov/pubmed/12611564.

Wang, Deqing, et al. �Study of the Effects of Total Flavonoids of Astragalus on Atherosclerosis Formation and Potential Mechanisms.� Oxidative Medicine and Cellular Longevity, Hindawi Publishing Corporation, 2012, www.ncbi.nlm.nih.gov/pmc/articles/PMC3306992/.

Wu, Hong Mei, et al. �Interventions for Preventing Infection in Nephrotic Syndrome.� The Cochrane Database of Systematic Reviews, John Wiley & Sons, Ltd, 18 Apr. 2012, www.ncbi.nlm.nih.gov/pubmed/22513919.

Yang, Qing-you, et al. �Effects of Astragalus on Cardiac Function and Serum Tumor Necrosis Factor-Alpha Level in Patients with Chronic Heart Failure.� Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine, U.S. National Library of Medicine, July 2010, www.ncbi.nlm.nih.gov/pubmed/20929124.

Zhang, Hong Wei, et al. �Astragalus (a Traditional Chinese Medicine) for Treating Chronic Kidney Disease.� The Cochrane Database of Systematic Reviews, U.S. National Library of Medicine, 22 Oct. 2014, www.ncbi.nlm.nih.gov/pubmed/25335553.


Modern Integrative Wellness- Esse Quam Videri

The University offers a wide variety of medical professions for functional and integrative medicine. Their goal is to inform individuals who want to make a difference in the functional medical fields with knowledgeable information that they can provide.

Arabinogalactan The Immune and Gut Enhancer

Arabinogalactan The Immune and Gut Enhancer

Do you feel:

  • Excessive belching, burping, or bloating?
  • Stomach pain, burning, or aching 1-4 hours after eating?
  • An overall sense of bloating?
  • Difficulty digesting roughage and fiber?
  • A sense of fullness during and after meals?

If you are experiencing any of these situations, then there might be some problems with your gut system or immune system. How about adding some arabinogalactan into your diet.

Around eighty-eight percent of Americans are living with compromised metabolic health and becoming overweight or obese. Some people are typically healthy and take active measures to stay that way through a healthy diet, which consists of eating the right nutritional food and exercising regularly. While with others, they are consuming high sugar and fatty processed foods and are being inactive and not exercising. When people fall behind on trying to achieve a healthy lifestyle, they need some reliable backup evidence to help them get back on track.

With the constant flood of information about the latest trendy diet or superfood airs on television, the radio waves, or being adversities on the online web and newspapers, it might be challenging for patients to find the right help that they need amongst all the media outlets. Two things can help influence a person’s overall health by supporting a person’s immune system function and even maintaining a healthy gut microbiome. The supplement, arabinogalactan, which is sourced from the larch trees, is a compound that can fill both roles to support a healthy, functional body.

Arabinogalactan

Arabinogalactan

Arabinogalactan is a fiber that is found in many plants; however, it is mostly found commonly in the wood from the larch tree, and the larch tree wood comes out larch arabinogalactan. Larch arabinogalactan is highly branched polysaccharides that have a galactan backbone with side chain acids of galactose and arabinose, which are both monosaccharides. Surprisingly though, arabinogalactan falls into the carbohydrate category known as hemicelluloses. Research shows that hemicelluloses are non-starch polysaccharides that can occur abundantly in the primary and secondary cells walls from plant cells. With arabinogalactan being found in all plant life from the seeds, roots, leaves, fruit, and sap, it is traditionally used to treat specific ailments.

Arabinogalactan Beneficial Properties

There are many beneficial properties that larch arabinogalactan can provide as this supplement can help stimulate the body’s immune system and even prevent viral and bacterial infections that enter the body. Arabinogalactan has been used as traditional medicine for centuries as people have been taking advantage of its medicinal properties. Some of the beneficial properties that arabinogalactan can prevent or even treat the following health conditions like:

  • Asthma
  • The common cold
  • High cholesterol
  • Liver cancer
  • Pneumonia

Studies even have shown that arabinogalactan can even promote a healthy gut flora in the body. The research shows that arabinogalactan can help resist digestion from the salivary enzymes and even the enzymes in the small intestines. When this happens, arabinogalactan allows itself to arrive at the large intestines. It transforms to be a prebiotic fiber, where it has high fermentability and can be used for beneficial colonic microorganisms. The research even shows how there is a unique chemical bond that forms the arabinogalactan molecules and making them resistant to digestion.

Arabinogalactan is a product of microbial fermentation known as short-chain fatty acids (SCFAs) and is with butyrate, propionate, and acetate. Since research shows that SCFAs play an essential role in the body’s gut health, especially butyrate, it has become the primary fuel source for colonic epithelial cells. Since butyrate helps increase mucin production in the gut system, it can even help contribute even better health by reducing the likelihood of pathogenic bacterial adhesion to the colon. With the combination of arabinogalactan, the gut system and the intestinal walls are well protected.

Butyrate and arabinogalactan can help each other improve the integrity of cellular tight junction. When the gut starts having obvious implications, butyrate and arabinogalactan can help maintain a proper intestinal permeability and limiting the passage of incomplete digested peptides into the body�s systemic circulation. Studies have shown that the immune response to these errant peptides can be a significant etiological and causal factor in numerous chronic illnesses, especially in autoimmune conditions. When a person consumes arabinogalactan, the supplement has been known to increase the colonic population of Bifidobacteria and Lactobacilli. Studies have found that these two organisms have a potent antimicrobial effect against pathogenic bacteria that is affecting the gut flora.

Conclusion

Arabinogalactan is a carbohydrate that is found in the larch tree and can provide support to the immune system and the gut system. This supplement is a powerhouse when it is consumed and can fight off pathogenic bacteria that can harm not only the body but also cause intestinal permeability to the gut, thus creating leaky gut. With arabinogalactan having these fantastic beneficial properties, the body will thank this carbohydrate for protecting the immune system and the gut system. Some products are used to help support the immune system and the gastrointestinal system by using advance formulas to provide more excellent stability to the body by offering hypoallergenic nutrients and enzymatic cofactors that the body much needs.

The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.


References:

Dion, Carine, et al. �Does Larch Arabinogalactan Enhance Immune Function? A Review of Mechanistic and Clinical Trials.� Nutrition & Metabolism, BioMed Central, 12 Apr. 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC4828828/.

Fasano, Alessio. �Zonulin, Regulation of Tight Junctions, and Autoimmune Diseases.� Annals of the New York Academy of Sciences, U.S. National Library of Medicine, July 2012, www.ncbi.nlm.nih.gov/pmc/articles/PMC3384703/.

H�tt, P, et al. �Antagonistic Activity of Probiotic Lactobacilli and Bifidobacteria against Entero- and Uropathogens.� Journal of Applied Microbiology, U.S. National Library of Medicine, June 2006, www.ncbi.nlm.nih.gov/pubmed/16696680.

R�os-Covi�n, David, et al. �Intestinal Short Chain Fatty Acids and Their Link with Diet and Human Health.� Frontiers in Microbiology, Frontiers Media S.A., 17 Feb. 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC4756104/.

Team, DFH. �Arabinogalactan � Immune Function Enhancer.� Designs for Health, 1 Oct. 2019, blog.designsforhealth.com/node/1117.

Team, UNCCH. �Only 12 Percent of American Adults Are Metabolically Healthy, Carolina Study Finds: UNC-Chapel Hill.� The University of North Carolina at Chapel Hill, 29 Nov. 2018, www.unc.edu/posts/2018/11/28/only-12-percent-of-american-adults-are-metabolically-healthy-carolina-study-finds/.

Wong, Cathy. �Can Larch Arabinogalactan Prevent Colds and Flu?� Verywell Health, Verywell Health, 12 Jan. 2020, www.verywellhealth.com/the-benefits-of-larch-arabinogalactan-89473.


Modern Integrative Wellness- Esse Quam Videri

The University offers a wide variety of medical professions for functional and integrative medicine. Their goal is to inform individuals who want to make a difference in the functional medical fields with knowledgeable information that they can provide.

Functional Endocrinology: Mercury and Autoimmune Connection

Functional Endocrinology: Mercury and Autoimmune Connection

Do you feel:

  • A bitter metallic taste in your mouth?
  • Inflammation your gut or in your joint?
  • Stomach pain, burning, or aching 1-4 hours after eating?
  • Offensive breath?
  • Unpredictable abdominal swelling?

If you are experiencing any of these situations, then you might be exposed to mercury in your body.

When it comes to autoimmune diseases, there has been a slight increase in autoimmune diseases that have been around over the past few decades. Everyone knows that when the immune system starts to attack itself, it can cause the body to develop autoimmune disruptors, and even some significant triggers can cause a malfunction in the body as well.

There are many ways that autoimmunity can occur in the body in many different ways. The first one is when the cells are mistaken as a foreign pathogen, and the body attacks itself. The second one is called molecular mimicry. This happens when the body starts to make an antibody to a specific antigen, and these antigens can take the resemblance of any specific proteins; thus, the body’s antibodies will attack the tissues. The third one is when the body becomes affected by environmental triggers and genetic stress; it starts to develop T-cells in the immune system.

Many local integrative doctors and health care professionals are working with functional medicine. They all understand that environmental triggers are one of the factors that can cause dysfunction in the body. With food sensitivities, environmental triggers, and lifestyle factors can cause a person’s body to have inflammation. Inflammation is not only in the joints, but it can also affect the gut’s health as well, causing leaky gut and dysbiosis. There are even toxins that the body can be in contact with that can also affect the immune system significantly. Heavy metals and xenobiotics can cause a total toxic burden in the body, and one of them is mercury.

Mercury

Also known as quicksilver, mercury is a liquid metal and is a naturally occurring element that is found outside in the air, water, soil. Most people are usually exposed to low levels of mercury by consuming fish and shellfish. Although it is safe to consume fish and shellfish, when humans are exposed to high levels of mercury is highly toxic and can lead to mercury poisoning, thus affecting the body.

Ultimate+Seafood+Combo-2_web

Studies have found that the connection link between gut health and autoimmune diseases has been in the news regularly with the exposure to high levels of mercury and becoming one of the most significant risk factors for the body to develop autoimmunity. In a 2015 study, author Emily Somers Ph.D. Sc. M. stated that even though mercury at low levels is generally safe are still associated with autoimmunity, and the exposure to mercury has stood out to be the leading risk factor for autoimmunity in the body.

Mercury Poisoning Symptoms

There are many signs and symptoms that mercury poisoning can cause the body to dysfunction. The effects of mercury poisoning can vary depending on the exposure level and on a person�s age. When mercury affects the nervous system, thus can lead to neurological symptoms like:

  • Physical tremors
  • Anxiety
  • Mood swings
  • Numbness
  • Memory problems

Other symptoms from mercury poisoning can appear even more if levels of mercury rise in the human body. Some of the severe symptoms can include:

  • Muscle weakness
  • Nausea and vomiting
  • Metallic taste in the mouth
  • Lack of motor functions
  • Muscle numbness
  • Difficulty walking or standing straight

There are more studies about mercury poisoning as they stated how mercury can increase the activation of the T-cell receptor and how self-reactive cells can escape the elimination process during T-cell selection. Other studies have found that mercury can induce autoimmune diseases in humans. For many local chiropractors and health professionals would always ask their patients if they have had any dental fillings in their teeth. If they do, then it turns out that the dental fillings may have mercury in them.

What many people do not know is that dental fillings, especially silver fillings, can contain about forty to fifty percent of mercury. If a person still has these types of fillings their teeth, they might have an increased risk of mercury exposure in their system. In order to reduce the mercury exposure in the body, anybody who has silver fillings can get them replaced with newer and safer alternatives for their fillings.

Conclusion

Mercury is a toxic element that can harm the human body and can develop autoimmune diseases in the immune system. Mercury can also cause many symptoms in the body can cause harm and dysfunction to a person. Sometimes a person may have silver fillings that may cause them to be exposed to mercury and can get them replaced to limit their exposure. Once there is no exposure to mercury in the immune system, the body will start to heal and function properly through a healthy diet and functional medicine. Some products are here to help support the immune system by providing the essential formula to the body and its many functioning systems.

The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.


References:

Bigazzi, P E. �Autoimmunity and Heavy Metals.� Lupus, U.S. National Library of Medicine, Dec. 1994, www.ncbi.nlm.nih.gov/pubmed/7704000.

Johnson, Jon. �Mercury Poisoning: Symptoms and Early Signs.� Medical News Today, MediLexicon International, 9 Jan. 2018, www.medicalnewstoday.com/articles/320563.php.

Pollard, K Michael, et al. �Toxicology of Autoimmune Diseases.� Chemical Research in Toxicology, U.S. National Library of Medicine, 15 Mar. 2010, www.ncbi.nlm.nih.gov/pmc/articles/PMC3076021/.

Team, DFH. �Mercury Exposure and the Autoimmune Connection.� Designs for Health, 9 Oct. 2018, blog.designsforhealth.com/mercury-exposure-and-the-autoimmune-connection.

Team, WHO. �Mercury and Health.� World Health Organization, World Health Organization, 31 Mar. 2017, www.who.int/news-room/fact-sheets/detail/mercury-and-health.


Modern Integrative Wellness- Esse Quam Videri

The University offers a wide variety of medical professions for functional and integrative medicine. Their goal is to inform individuals who want to make a difference in the functional medical fields with knowledgeable information that they can provide.

 

Zinc’s Functional Role In The Body

Zinc’s Functional Role In The Body

Do you feel:

  • Alternating between constipation and diarrhea?
  • Unexplained itchy skin?
  • Acne and unhealthy skin?
  • Excessive hair loss?
  • Difficulty gaining weight?

If you are experiencing any of these situations, then you might be experiencing some zinc deficiency in your body.

Whenever someone thinks of zinc, their minds go to the immune system in the body. Surprisingly though, the immune system needs zinc so that way, the body could function properly. Not only that, but zinc is the unsung mineral that has numerous functions and structural roles that is throughout the body. Zinc also makes sure that the body is at a healthy weight for anyone who may have disorders from chronic illnesses or from autoimmune diseases that can make the bodyweight fluctuate from being overweight to underweight.

Zinc Beneficial Properties

One of the things to know is that zinc cannot be naturally produced in the body, but it can be consumed through food or supplements. This mineral can help the body in numerous ways since it is the second abundant trace mineral that is present in the body, right after iron. Research shows that zinc is necessary for 300 enzymes to activate the body�s metabolism and many of its functions to make sure that each of the systems is working correctly, especially the immune system.

Zinc_gluconate

Zinc has many beneficial properties that can help support a healthy body. When it comes to the immune system, studies have shown that zinc can act as an antioxidant and help fight inflammation. The studies even stated that the effects of zinc could reduce the symptoms of the common cold within 24 hours. There are about five zinc supplements that are excellent for the body and can be beneficial to make sure that each system, including the immune system. They are:

  • Zinc gluconate: This supplement is one of the most over the counter forms of zinc that is usually found in the form of cold remedies like cough drops, lozenges and nasal sprays that are found in local stores.
  • Zinc acetate: Just like zinc gluconate, this supplement is added to lozenges to help reduce cold symptoms and to speed up the recovery process.
  • Zinc sulfate: For anyone that has a zinc deficiency, this supplement has been known to help reduce severe acne on the skin.
  • Zinc picolinate: This supplement can be absorbed better into the body than the other forms of zinc, as the research shows.
  • Zinc orotate: This supplement is bounded with orotic acid and is one of the most common zinc supplements that can be found in the market or the grocery stores.
  • Zinc citrate: Studies have found that this zinc supplement can be absorbed like zinc gluconate; however, it has a more appealing taste that is less bitter, when it is consumed.

With these zinc supplements, they can be found in any local stores that carry supplements, cough drops, lozenges at an affordable price, and can help increase a person’s intake as well as impact their health.

Zinc Deficiency Symptoms

Even though a person cannot produce zinc in their body, it is rare for someone to have a severe zinc deficiency unless it is from a rare genetic mutation or anyone that is taking any specific immune-suppressing medication. Research has found that anyone who has acrodermatitis enteropathica can have the symptoms of a severe zinc deficiency. Acrodermatitis enteropathica is a recessive condition that is autosomal and can result in a person to have a severe zinc deficiency. The symptoms can range from impaired growth to skin rashes.

There are other ways that zinc deficiency can cause symptoms that can affect the body and cause problems as well. They can include:

  • Loss of appetite
  • Anemia
  • Diarrhea
  • Skin conditions like acne or eczema
  • Increase the risk of chronic diseases like Crohn’s disease or chronic kidney disease

Many healthcare professionals have found that zinc deficiency has a severe wide-ranging consequence and is one of the prevalent micronutrient deficiencies in the world. Studies have found that when a person has a low zinc intake can contribute to altering neurotransmitter levels, especially GABA in the brain. The research has found and suggested that when a person takes a zinc supplement can help improve neurodegenerative functions like depression and anxiety.

Conclusion

Zinc is one of the minerals that the body cannot produce naturally. When a person takes zinc in a supplement form or food form, it can provide native support for the body and the systems. Zinc is highly crucial in the immune system because when the immune system is deficient, it can cause a development of chronic illnesses that can harm the body. Some products can help the body have a healthy immune system by providing support to the metabolic system and the gastrointestinal system.

The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.


References:

Barrie, S A, et al. �Comparative Absorption of Zinc Picolinate, Zinc Citrate and Zinc Gluconate in Humans.� Agents and Actions, U.S. National Library of Medicine, June 1987, www.ncbi.nlm.nih.gov/pubmed/3630857.

Birmingham, C L, and S Gritzner. �How Does Zinc Supplementation Benefit Anorexia Nervosa?� Eating and Weight Disorders: EWD, U.S. National Library of Medicine, Dec. 2006, www.ncbi.nlm.nih.gov/pubmed/17272939.

Gupta, Mrinal, et al. �Zinc Therapy in Dermatology: a Review.� Dermatology Research and Practice, Hindawi Publishing Corporation, 2014, www.ncbi.nlm.nih.gov/pmc/articles/PMC4120804.

Hemil�, Harri, et al. �Zinc Acetate Lozenges May Improve the Recovery Rate of Common Cold Patients: An Individual Patient Data Meta-Analysis.� Open Forum Infectious Diseases, Oxford University Press, 3 Apr. 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5410113/.

Higdon, Jane. �Zinc.� Linus Pauling Institute, 1 Jan. 2020, lpi.oregonstate.edu/mic/minerals/zinc#impaired-immune-function.

Kubala, Jillian. �Zinc: Everything You Need to Know.� Healthline, 14 Nov. 2014, www.healthline.com/nutrition/zinc.

Lim, Karen H C, et al. �Iron and Zinc Nutrition in the Economically-Developed World: a Review.� Nutrients, MDPI, 13 Aug. 2013, www.ncbi.nlm.nih.gov/pmc/articles/PMC3775249/.

Nistor, Nicolai, et al. �Acrodermatitis Enteropathica: A Case Report.� Medicine, Wolters Kluwer Health, May 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC4902399/.

Team, DFH. �Functional Roles of Zinc.� Designs for Health, 28 Jan. 2020, blog.designsforhealth.com/node/1193.

Wegm�ller, Rita, et al. �Zinc Absorption by Young Adults from Supplemental Zinc Citrate Is Comparable with That from Zinc Gluconate and Higher than from Zinc Oxide.� The Journal of Nutrition, American Society for Nutrition, Feb. 2014, www.ncbi.nlm.nih.gov/pubmed/24259556.

Wieringa, Frank T, et al. �Determination of Zinc Status in Humans: Which Indicator Should We Use?� Nutrients, MDPI, 6 May 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC4446750/.

Zastrow, Melissa L, and Vincent L Pecoraro. �Designing Hydrolytic Zinc Metalloenzymes.� Biochemistry, American Chemical Society, 18 Feb. 2014, www.ncbi.nlm.nih.gov/pubmed/24506795.


Modern Integrative Wellness- Esse Quam Videri

The University offers a wide variety of medical professions for functional and integrative medicine. Their goal is to inform individuals who want to make a difference in the functional medical fields with knowledgeable information that they can provide.

What You Should Know About Histamine Intolerance and Dieting

What You Should Know About Histamine Intolerance and Dieting

Do you feel:

  • Shaky, jittery, or have tremors?
  • Stomach pain, burning, or aching 1-4 hours after eating?
  • Agitated, easily upset, nervous?
  • Lightheaded if meals are missed?
  • Digestive problems subside with rest and relaxation?

If you are experiencing any of these situations, then you might be experiencing a histamine attack on your immune system.

During an allergic response, the body’s immune system starts to react by releasing various immune compounds to protect itself from foreign substances that identify as harmful. One of these immune compounds, known as histamine, is commonly present in a variety of foods. When histamine is elevated in the body, it is due to a high dietary intake or an inability to break it down, so individuals may experience allergic symptoms from a histamine reaction.

What is Histamine?

histamine

Histamine is a compound that is formed through the metabolism of specific amino acids in the immune system. There are a variety of levels of histamine that is found naturally in the foods that people consume. It is also produced by the body where it is in specific immune cells, including mast cells and basophils. During an allergic and other immune response, histamine is released from these cells, and consuming large quantities of histamine that is over 100 mg may result in a mild adverse reaction. Studies have shown that if histamine is consumed in a higher amount that is over 1000 mg, it can lead to histamine intoxication or histamine poisoning.

What is Histamine Intolerance?

Under normal conditions, histamine is released in the body or ingested through food, and it is broken down by two enzymes: HNMT (histamine-N-methyltransferase) and DAO (diamine oxidase). High levels of histamine can occur in individuals that have reduced activity of these enzymes. When histamine levels are increased, or the ability to break down histamine is impaired, individuals may experience histamine intolerance, which will generally present itself as an allergic reaction to the immune system.

What Causes Histamine Intolerance?

Specific individuals may have an increased sensitivity to biogenic amines like histamine. Some factors have been associated with an increased risk of histamine intolerance, including:

  • Gastrointestinal conditions (Crohn�s disease, gastric and colon ulcers, gastritis, irritable bowel syndrome)
  • Certain health conditions (coronary heart disease, hypertension, respiratory diseases)
  • Vitamin B12 deficiency
  • Certain medications that inhibit the activity of histamine-degrading enzymes (acetylcysteine, metamizole, metoclopramide, metronidazole, verapamil)

csm_Histaminintoleranz_Abb2_englisch_NS-Mappe_1204883ba1

Mast cell conditions can increase the secretion of histamine. Since mast cells are found throughout the body, they are involved with the innate immune response as well as being the primary source of histamine in the intestines. Studies show that when specific immune receptors detect a foreign substance in the body, the mast cells secrete inflammatory compounds like histamine as a protective response. Mast cell activation is characterized by increasing plasma and urine histamine levels as well as an increased histamine metabolite in the urine. Several conditions are associated with mast cell activation, including:

  • Allergies that are mediated by IgE (immunoglobulin-E) and other hypersensitivities
  • Atopic conditions
  • Mastocytosis
  • Primary mast cell disorders

Signs and Symptoms of Histamine Intolerance

With histamine intolerance symptoms being presented as an allergic response, some of the signs and symptoms include:

  • Arrhythmia
  • Asthma
  • Diarrhea
  • Flushing
  • Headaches
  • Hypotension
  • Symptoms of rhinoconjunctivitis (nasal congestion, post-nasal drip, sneezing)
  • Pruritus (itchy skin)
  • Urticaria (hives)

Histamine-free Diet

With dietary support for histamine intolerance, it may involve a histamine-free diet. Studies have been examining the effects of four-week histamine-free diet intervention on 22 individuals that have CU (chronic urticaria). Chronic urticaria is a common skin condition that is characterized by episodes of red marks and swelling that last longer than six weeks on the body.

A study found that when it is being compared to baseline, plasma histamine levels were significantly reduced when following the diet. Additionally, USS (urticaria severity score) and (UAS), both decreased following the intervention. It means that a histamine-free diet may help improve symptoms that are associated with dietary histamine intake or histamine intolerance like chronic urticaria in the body.

Histamine-rich-foods-High-Histamine-Foods-List-conners-clinic

Research also shows that when individuals follow a histamine-reduced diet, it may increase the levels of the DAO enzyme. Research also demonstrated that when individuals followed the histamine-reduced diet for an average of 13 months, the increased levels of DAO were correlated with the degree of compliance to the diet. When high-histamine and histamine-liberated foods are eliminated, the individual�s tolerance levels can be determined by slowly reintroducing foods to test for potential reactions.

Certain foods may increase histamine levels by providing a dietary source or by liberating histamine in the body. Studies have found that it is essential to note that inconsistent levels of histamine are found in various foods and that the levels may fluctuate based on the maturity, storage, and processing of the food.

Here are the high-histamine foods to avoid on a histamine-free diet. They are:

  • Aged cheese (cheddar, gouda, parmesan)
  • Alcohol (beer, champagne, wine)
  • Certain produce (avocado, eggplant, spinach, tomato)
  • Cured meats (fermented sausage, salami)
  • Fermented vegetables (sauerkraut)
  • Fish products (dried anchovies, fish sauce)

Here are the histamine-liberating foods to avoid on a histamine-free diet as well. They are:

  • Certain fruits (citrus, pineapple, banana, strawberries, papaya)
  • Cocoa
  • Egg whites
  • Food additives (coloring, flavoring, preservatives, stabilizers)
  • Legumes
  • Licorice

Other Considerations

With methods surrounding food preparations that should be considered, researchers have suggested that people should consume food that is fresh as possible and boiled rather than frying or grilling food may help reduce the intake of biogenic amines like histamine. Studies have shown that spoiled foods have been found to have high levels of histamine, so it is essential to be mindful when consuming leftovers, especially leftover fish. There are some individuals with histamine intolerance that may benefit from taking antihistamine medication or a DAO supplement. There are also certain nutrients, including copper, vitamin B6, and vitamin C that can help support histamine degradation.

Conclusion

When the body is suffering from an allergic response, its’ immune system starts to react by sending out various immune compounds that attack harmful foreign substances. Histamine is one of the immune compounds that is produced and broken down to HNMT and DAO. Histamine can also trigger an asthma attack on individuals, while certain foods can contain high-histamine and histamine-liberating properties that can be harmful in the body. Some products use an advanced formula that helps support the immune system, targets amino acids, and supports antioxidant processes to make sure that the body is functioning correctly.

The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900.


References:

Martin, San Mauro, et al. �Histamine Intolerance and Dietary Management: A Complete Review.� Adrianaduelo, 31 Aug. 2016, www.adrianaduelo.com/wp-content/uploads/2016/09/2016_Histamine-intolerance-and-dietary-management.pdf.

Chung, Bo Young, et al. �Effect of Different Cooking Methods on Histamine Levels in Selected Foods.� Annals of Dermatology, The Korean Dermatological Association; The Korean Society for Investigative Dermatology, Dec. 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5705351/.

Dougherty, Joseph M. �Allergy.� StatPearls [Internet]., U.S. National Library of Medicine, 28 July 2019, www.ncbi.nlm.nih.gov/books/NBK545237/.

Fong, Michael. �Histology, Mast Cells.� StatPearls [Internet]., U.S. National Library of Medicine, 20 Sept. 2019, www.ncbi.nlm.nih.gov/books/NBK499904/.

Lackner, Sonja, et al. �Histamine-Reduced Diet and Increase of Serum Diamine Oxidase Correlating to Diet Compliance in Histamine Intolerance.� European Journal of Clinical Nutrition, U.S. National Library of Medicine, Jan. 2019, www.ncbi.nlm.nih.gov/pubmed/30022117.

Maintz, Laura, and Natalija Novak. �Histamine and Histamine Intolerance.� OUP Academic, Oxford University Press, 1 May 2007, academic.oup.com/ajcn/article/85/5/1185/4633007.

Reese, Imke, et al. �German Guideline for the Management of Adverse Reactions to Ingested Histamine: Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the German Society for Pediatric Allergology and Environmental Medicine (GPA), the German Association of Allergologists (AeDA), and the Swiss Society for Allergology and Immunology (SGAI).� Allergo Journal International, Springer Medizin, 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5346110/.

Son, Jee Hee, et al. �A Histamine-Free Diet Is Helpful for Treatment of Adult Patients with Chronic Spontaneous Urticaria.� Annals of Dermatology, The Korean Dermatological Association; The Korean Society for Investigative Dermatology, Apr. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC5839887/.

S�nchez-P�rez, S�nia, et al. �Biogenic Amines in Plant-Origin Foods: Are They Frequently Underestimated in Low-Histamine Diets?� Foods (Basel, Switzerland), MDPI, 14 Dec. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6306728/.

Unknown, Unknown. �Histamine Intolerance & Diet: What You Should Know.� Fullscript, 11 Nov. 2019, fullscript.com/blog/histamine-intolerance.