Before the body can benefit from consumed nutrients, the gastrointestinal tract has to digest and absorb the foods. Before eating, the body needs to feel hungry. However, hunger is not the same as appetite. Hunger is a physical reaction caused by hormonal and chemical changes in the body when fuel is needed. Appetite is more of a desire to eat and can be a learned response. It is one reason why individuals can eat when they are not hungry. The body comprises different hormones that regulate hunger, digestion, and appetite.
Hunger Digestion Regulating Hormones
Hunger Hormones
Hunger is the feeling when the body needs food. When the body has enough, hunger should subside. That’s because various hormones regulate hunger.
Leptin
Leptin is a hormone secreted by adipose tissue/fat into the bloodstream.
The more fat in the body, the higher the blood levels of leptin.
Leptin level also increases with food intake and is higher in females than males, but overall, it lowers with age.
Increased leptin levels trigger the hypothalamus to reduce hunger.
Ghrelin
Ghrelin is a hormone produced by the stomach and small intestine when the stomach is empty.
Like leptin, it also works with the hypothalamus.
However, instead of suppressing hunger, it increases hunger.
Insulin
The pancreas produces this hormone.
It is mostly known for regulating blood sugar levels.
It also suppresses hunger.
Adiponectin
Adiponectin is a hormone secreted by fat cells.
As body fat levels go down, this hormone goes up.
If fat levels go up, adiponectin levels go down.
Cholecystokinin
Cholecystokinin is a hormone produced in the small intestine during and after a meal.
It triggers the release of bile and digestive enzymes into the small intestine.
These suppress hunger and make the body feel full.
Peptide YY
This hormone suppresses appetite for about 12 hours after eating.
Made by both the large and small intestines after eating.
Glucocorticoids
Adrenal glands make these hormones, and their primary function is to regulate inflammation and other processes, but they also impact hunger.
A cortisol deficiency reduces appetite, but excessive amounts of glucocorticoids increase hunger.
Digestion Hormones
Digestion is coordinated and regulated by hormones.
Gastrin
Gastrin is a hormone the stomach and the small intestine release when eating.
Gastrin stimulates the release of hydrochloric acid and pepsinogen in the stomach to speed up digestion.
Gastrin stimulates glucagon, which works with insulin to regulate blood sugar.
Secretin
Secretin is a hormone made by the small intestine.
It is secreted into the bloodstream when the acidic chyme from the stomach enters the small intestine.
Secretin stimulates the pancreas to release bicarbonate digestive liquids into the small intestine.
The bicarbonate neutralizes the acidity.
Secretin acts on the stomach to trigger the production of pepsinogen to help break down proteins.
Cholecystokinin – CCK
The small intestine makes and releases CCK into the bloodstream.
Essential fat digestion stimulates the gallbladder to release bile into the small intestine.
It also triggers the pancreas to release various digestive enzymes so they can break down fats, carbohydrates, and proteins.
It stimulates the pancreas to release insulin and slows down stomach digestive activity.
Peptide YY and Enterogastrone
Released by the small intestine, two more hormones slow digestion down and decrease the production of digestive secretions.
Chiropractic Care and Metabolism
References
Chandra, Rashmi, and Rodger A Liddle. “Cholecystokinin.” Current Opinion in Endocrinology, diabetes, and Obesity vol. 14,1 (2007): 63-7. doi:10.1097/MED.0b013e3280122850
Davis, Jon. “Hunger, ghrelin and the gut.” Brain Research vol. 1693, Pt B (2018): 154-158. doi:10.1016/j.brainres.2018.01.024
Gupta K, Raja A. Physiology, Gastric Inhibitory Peptide. [Updated 2022 Sep 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: www.ncbi.nlm.nih.gov/books/NBK546653/
Konturek, S J et al. “Brain-gut axis and its role in the control of food intake.” Journal of Physiology and Pharmacology: an official journal of the Polish Physiological Society vol. 55,1 Pt 2 (2004): 137-54.
Prosapio JG, Sankar P, Jialal I. Physiology, Gastrin. [Updated 2023 Apr 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: www.ncbi.nlm.nih.gov/books/NBK534822/
Rix I, Nexøe-Larsen C, Bergmann NC, et al. Glucagon Physiology. [Updated 2019 Jul 16]. In: Feingold KR, Anawalt B, Blackman MR, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-. Available from: www.ncbi.nlm.nih.gov/books/NBK279127/
Suzuki, Keisuke, et al. “The role of gut hormones and the hypothalamus in appetite regulation.” Endocrine Journal vol. 57,5 (2010): 359-72. doi:10.1507/endocrine.k10e-077
Tack, Jan, et al. “The gastrointestinal tract in hunger and satiety signaling.” United European gastroenterology journal vol. 9,6 (2021): 727-734. doi:10.1002/ueg2.12097
Zanchi, Davide, et al. “The impact of gut hormones on the neural circuit of appetite and satiety: A systematic review.” Neuroscience and biobehavioral reviews vol. 80 (2017): 457-475. doi:10.1016/j.neubiorev.2017.06.013
When it comes to our bodies, many functioning systems help the body regulate its temperature, provide mobility and stability when in motion, and protect the host from pathogens that enter inside to cause havoc. One of the systems that helps the body is the endocrine system, which produces many hormones to keep the body functioning properly. The thyroid, a small, butterfly-shaped organ at the base of the neck, produces the hormones in the body. The thyroid helps regulate hormone production; however, when pathogen factors affect the body’s hormonal production, it can lead to musculoskeletal pain and dysfunction. Today’s article examines how the thyroid produces hormones, how hormone imbalances are connected with musculoskeletal pain, and how MET therapy can help restore hormone imbalances from affecting the body in the future. We utilize information about our patients to certified medical providers using soft tissue therapies like MET to reduce musculoskeletal pain associated with hormonal imbalances. We encourage patients by referring them to associated medical providers based on their diagnosis while supporting the fact that education is a marvelous way to ask our providers the most interesting questions at the patient’s acknowledgment. Dr. Alex Jimenez, D.C., incorporates this information as an educational service. Disclaimer
How Does The Thyroid Produce Hormones?
Do you feel muscle weakness or pain in certain parts of your body? Do you feel out of breath after walking for a short distance? Or do you feel sluggish throughout the entire day? When many individuals are dealing with these numerous issues, it could be due to their hormones being imbalanced from their thyroids. When it comes to the body, the endocrine system is the mastermind of producing different hormones for the body to help regulate all the biological processes. One of the vital organs of the endocrine system is the thyroid. Studies reveal that the thyroid is an endocrine gland located in the inferior anterior neck of the body and produces T4 and T3 hormones for the body to function properly. The thyroid hormones affect many of the vital organs and body tissues as they help with the following:
Cardio output and increased resting heart rate
Increases BMR (basal metabolic rate), heat production, and oxygen consumption
Stimulates resting respiratory rate and the nervous system
Plays a role in reproductive health and other endocrine organ function
Additional studies have revealed that thyroid hormones help control the body’s metabolism, growth, and other bodily functions while having a casual relationship with the HPT (hypothalamic-pituitary-thyroid) axis. What this relationship does is that it makes sure that the body is working properly in any environment. However, when unwanted pathogens start to affect thyroid hormone production, it can cause a hormone imbalance and lead to unwanted pain-like symptoms in the vital organs and musculoskeletal tissues.
Hormone Imbalances & Musculoskeletal Pain
When unwanted pathogens are associated with environmental factors affecting the body, it can lead to pain-like symptoms that can lead to musculoskeletal pain. In the book, “Clinical Applications of Neuromuscular Techniques,” written by Dr. Judith Walker DeLany, L.M.T., and Leon Chaitow, N.D., D.O., stated that there is a connection between hormonal imbalances and musculoskeletal pain as there are many environmental factors that can influence how much or how little hormone production is being produced from the thyroid. The book also mentions that some of the clinical signs of thyroid hormone deficiency include:
Dry skin and thinning hair
Unnatural fatigue
Unexplained weight increase
Aching muscles
Mental confusion
When the body is dealing with hormone imbalances associated with musculoskeletal pain, studies reveal that symptoms of fatigue, anxiety, irritability, and increased oxidative stress can cause the muscular tissues and ligaments to be weak and cause overlapping risk profiles when the body is in motion. To that point, hormone imbalances could lead to muscle and joint pain associated with myofascial trigger points and muscle shortness.
Finding Hormonal Harmony- Video
Have you been experiencing muscle or joint pain? Do you often feel anxious or irritable constantly? Or have you noticed that you are extremely sensitive to the cold? Many of these pain-like issues are signs and symptoms associated with hormone imbalances in the body and can lead to musculoskeletal pain. The body needs hormones to help regulate body temperature, control the body’s metabolism, and help stimulate the endocrine and body systems. Hormones are secreted from the thyroid and travel to the important muscles, organs, and tissues through the bloodstream to assist and help each body section function properly. When pathogens start to disrupt hormone production, the thyroid can overproduce or underproduce hormone secretion and cause many overlapping risk profiles to the body and musculoskeletal system. Fortunately, there are many ways to regulate hormones and reduce the effects of musculoskeletal pain. The video above explains that increasing certain vitamin intake, eating healthy, whole-nutritional foods, and getting adequate exercise and sleep can regulate hormone production and reduce the effects of musculoskeletal pain. These various treatments can be combined with therapy to help realign the body and restore it naturally.
MET Therapy Restoring Hormone Imbalances
Many available therapies can reduce the effects of hormonal imbalances associated with musculoskeletal pain. Treatments like MET (muscle energy techniques) allow many pain specialists to use soft tissue techniques to reduce pain-like symptoms and will enable the body to restore itself naturally. Research studies have revealed that soft tissue therapies like MET can reduce pain, improve body function, and reduce disability. MET therapy can be combined with nutritional foods, hormone therapies, and bodywork strategies that can help regulate hormone production in the thyroid. When a person starts to go to treatment for any ailments affecting their body, it allows these individuals to be more mindful of what is happening to their bodies and make small meaningful changes to their health and wellness.
Conclusion
When it comes to maintaining the body’s health and wellness, it’s important to ensure that unwanted pathogens don’t start affecting thyroid hormone production. The thyroid is a small gland located at the base of the neck that secretes out hormones to the rest of the body. When the thyroid over or under-produces hormones in the organs, muscles, and tissues, it can lead to pain-like symptoms that affect the body’s system and potentially lead to musculoskeletal disorders. Treatments like MET therapy combined with nutritional whole foods and exercises can reduce the effects of hormone imbalances associated with musculoskeletal disorders. This amazing combination allows the body to heal naturally and allows the individual to be pain-free.
References
Armstrong, Maggie, et al. “Physiology, Thyroid Function – Statpearls – NCBI Bookshelf.” In: StatPearls [Internet]. Treasure Island (FL), 13 Mar. 2023, www.ncbi.nlm.nih.gov/books/NBK537039/.
Chaitow, Leon, and Judith Walker DeLany. Clinical Applications of Neuromuscular Techniques. Churchill Livingstone, 2003.
Day, Joseph M, and Arthur J Nitz. “The Effect of Muscle Energy Techniques on Disability and Pain Scores in Individuals with Low Back Pain.” Journal of Sport Rehabilitation, May 2012, pubmed.ncbi.nlm.nih.gov/22622384/.
Shahid, Muhammad A, et al. “Physiology, Thyroid Hormone – StatPearls – NCBI Bookshelf.” In: StatPearls [Internet]. Treasure Island (FL), 8 May 2022, www.ncbi.nlm.nih.gov/books/NBK500006/.
VandeVord, Pamela J, et al. “Chronic Hormonal Imbalance and Adipose Redistribution Is Associated with Hypothalamic Neuropathology Following Blast Exposure.” Journal of Neurotrauma, 1 Jan. 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC4700394/.
Dr. Alex Jimenez, D.C., presents how to look for signs of hormonal imbalances in men and how different treatment strategies, like chiropractic care, can help regulate hormonal functionality in the body. We direct patients to certified providers that provide functional hormonal replacement treatments that can restore body functionality. We acknowledge each patient and their symptoms by referring them to our associated medical providers based on their diagnosis to understand better what they are dealing with. We understand that education is a tremendous way to ask our providers various questions that apply to the patient’s knowledge. Dr. Jimenez, D.C., applies this information as an educational service. Disclaimer
Hormone Imbalances
Dr. Alex Jimenez, D.C., presents: Today, we will be looking at how to look for the signs of hormonal imbalances in men and how chiropractic care can help with the symptoms associated with hormonal imbalances. We need to understand the subtypes of hormonal deficiency to enable appropriate treatment strategies like chiropractic care. So when it comes to hormones in the body, it is important to know how hormones function in the body and what happens when comorbidities are associated with hormonal imbalances. The hormonal imbalances in the male body could cause physiologic effects of low testosterone correlating with disruptive factors.
Now hormones in both male and female bodies provide various actions that make the body functional. This includes:
Regulating body temperature
Sexual function
Work with other hormones (insulin, DHEA, cortisol)
Support the major body systems
When it comes to the male body, the two main hormones, androgen and testosterone, can help with cognitive function. However, when the body begins to age naturally, the hormonal process begins to decrease in the male body and causes chronic illnesses to start to cause problems in the body. When this happens, it can cause the individual to be in pain and disrupt daily activities.
Dr. Alex Jimenez, D.C., presents: Since many environmental disruptors can affect the body and cause hormonal imbalances, they can cause various symptoms in many test results when patients are being examined by their primary doctors. Signs of chronic fatigue, brain fog, depression, increased muscle mass, and low libido correlates with testosterone deficiency and can make the body dysfunctional. And if there is chronic hormonal dysfunction in the body, it can also lead to inflammation associated with hormonal deficiency. When inflammation starts to affect the muscles and joints of the male body, it can lead to issues affecting the back, hips, legs, shoulders, and neck that can cause limited mobility, muscle fatigue, increased body fat, and a decrease in bone mineral density.
Low testosterone levels in the body can overlap with pre-existing conditions that correlate with metabolic syndrome associated with hypogonadism. Hypogonadism is when the body’s reproductive organs produce little to no hormones for sexual function. Hypogonadism can affect about 30% of all males between the ages of 40-79. To that point, it causes the male body to produce more leptin hormones and can negatively affect the brain when it comes to releasing these hormones to the body. At the hypothalamic level of gonadotropin-releasing hormones, we have increased sensitivity at the hypothalamus to negative feedback from androgens. This can be many factors that can contribute to low male testosterone levels:
Diet
Stress
Toxin exposure
Osteoporosis
Decreased hair density
Erectile dysfunction
Andropause
When the reproductive organs produce little to no hormones, they can develop andropause and cause testosterone levels to diminish. Andropause is the male version of menopause for females, which can contribute to other conditions like dementia, Alzheimer’s, diabetes, and metabolic syndrome. How is metabolic syndrome associated with andropause when it comes to hormone imbalances? Well, low levels of testosterone in the body can increase insulin levels, causing insulin resistance, which then leads to an increase in BMI in the body. To that point, disorders like chronic stress can lower DHEA and testosterone hormone levels, which can then increase insulin levels and cause more pain-like issues in the body.
Chiropractic Care & Hormones
Dr. Alex Jimenez, D.C., presents: Now all is not lost, as there are ways to improve hormone production in the body. Many individuals can exercise regularly to lower cortisol and insulin levels while boosting testosterone levels. Another way to improve hormone dysfunction is by going to various therapies like chiropractic care to help reduce some of the symptoms associated with hormonal imbalances. Now how would chiropractic care be correlated with hormonal imbalances? Isn’t just manual manipulation to the back?
Surprisingly chiropractic care is more than just manipulating the spine when it is in subluxation. As stated earlier, hormonal imbalances can lead to chronic muscle and joint stress that can become inflamed and lead to chronic issues. When hormonal imbalances in the body cause low testosterone production, it can cause stress on the muscle groups and affect the joints. To that point, the body will be in constant pain or succumb to various injuries. So, incorporating chiropractic care as part of treatment can help improve the body’s musculoskeletal structure and how to deal with stress, allowing the nervous system, where hormones are being sent to different areas in the body, to function properly and operate normally. Chiropractic care enables the musculoskeletal structure to be pain-free from musculoskeletal dysfunction associated with hormone imbalances and can be combined with other treatments.
Conclusion
Utilizing and incorporating chiropractic care and hormone therapy can allow the body to function with normal hormone levels and reduce the pain-like symptoms that may affect the body’s muscles and joints. Chiropractic care combined with a nutritional diet that helps with hormone regulation and physical therapy can help the body’s hormone levels to be normal. To that point, this combination of treatments can improve muscle growth and reduce the symptoms associated with hormone imbalances that can cause muscle and joint pain associated with other pre-existing conditions related to hormone balance.
Dr. Alex Jimenez, D.C., presents how various treatments can help with adrenal insufficiency and can help regulate hormone levels in the body in this 2-part series. Since hormones play a vital role in the body by controlling how the body functions, it is important to know what the trigger is that is causing overlapping issues in the body. In Part 1, we looked at how adrenal insufficiencies affect different hormones and their symptoms. We refer patients to certified providers that include hormone treatments that relieve adrenal insufficiencies affecting the body while ensuring optimal health and wellness for the patient through various therapies. We appreciate each patient by referring them to associated medical providers based on their diagnosis when it’s appropriate to understand better what they are feeling. We understand that education is an excellent and inquisitive way to ask our providers various intricated questions at the patient’s request and knowledge. Dr. Jimenez, D.C., utilizes this information as an educational service. Disclaimer
Treatments For Adrenal Insufficiencies
Dr. Alex Jimenez, D.C., presents: When it comes to adrenal insufficiencies, the body has various symptoms that can cause the person to feel low on energy and pain in different areas. Since hormones are produced in the adrenal glands, they help maintain how vital organs and muscles work to keep the body functional. When various factors affect the body, disrupting the adrenal glands, it can cause hormone production to over or underproduce. To that point, it can correlate to numerous symptoms that cause the body to be dysfunctional. Fortunately, there are various treatments that many people can incorporate into their daily lives to promote hormone regulation.
Now everyone has different ways to lower their stress, which is fine as there are various treatments that a person may like to try, and if they are in a treatment plan that their doctor developed for them, they can find ways to get their health and wellness back. Many individuals sometimes participate in meditation and yoga to practice mindfulness. Now meditation and yoga have amazing benefits in lowering oxidative stress and cortisol levels associated with chronic stress. By looking at how adrenal insufficiencies can cause an increase in insulin, cortisol, and DHEA dysfunction in the HPA axis, many doctors would devise a treatment plan for their patients that can help lower the oxidative stress markers and regulate hormonal production. So if one of the treatments is meditation or yoga, many individuals who practice yoga and meditation will begin to notice how they are feeling after taking a few deep breaths and begin to feel mindful of their surroundings. This causes many people to improve their quality of life associated with decreased cortisol levels.
How Mindfulness Can Lower Stress
Dr. Alex Jimenez, D.C., presents: Another available treatment that can help with adrenal insufficiencies is an 8-week mindfulness treatment that can help lower cortisol levels from escalating in the body to cause more issues than a person is dealing with. Depending on what stage the HPA axis dysfunction is affecting the body, taking the time for yourself can benefit you in the long run. An example would be taking a hike on a nature walk path. The change in the environment can help a person relax and be at ease. This allows the body to let go of unnecessary pent-up stress affecting a person’s mood, functionality, and mental health when a change of scenery can help them relax and recharge. To that point, it allows the HPA axis to relax as well.
Another example of how mindfulness can help treat adrenal insufficiencies associated with hormonal dysfunction is by providing neurofeedback to those with chronic PTSD. Individuals with traumatic experiences have PTSD, which can hinder their ability to function in the world. When they go through a PTSD episode, their bodies will begin to lock up and tense, causing their cortisol levels to rise. To that point, this causes an overlap of symptoms associated with muscle and joint pain. Now how does mindfulness plays its part when it comes to treatment? Well, many doctors specializing in treating PTSD will do an EMDR test. EMDR stands for eye, movement, desensitization, and reprogramming. This allows PTSD patients to have their HPA axis rewired and reduce the neuron signals in their brains and help lower any cortisol levels causing adrenal insufficiencies in their bodies. Incorporating EMDR testing into PTSD patients allows them to find the issue causing the trauma through brain spotting, where the brain replays the traumatic memories and helps rewire the brain to release the trauma out of the body and start the healing process.
Vitamins & Supplements
Dr. Alex Jimenez, D.C., presents: Another technique many individuals can begin if they want to regulate their hormones is by taking supplements and neutraceuticals to help replenish hormonal function and the body. Choosing the right vitamins and supplements is not difficult if you don’t want to consume them in pill form. Many vitamins and supplements can be found in nutritious whole foods with specific nutrients that can improve hormone production and make a person feel full. Some of the vitamins and supplements that can help with hormone balance include:
Magnesium
B vitamins
Probiotics
Vitamin C
Alpha-lipoic acid
Omega-3 Fatty Acid
Vitamin D
These vitamins and supplements can help communicate with the other hormones the body produces and help balance hormonal production. Now, these treatments can help many people with hormonal imbalances in their bodies, and there are times when the process can be tough. Just remember that making these small changes can have a huge effect in the long run regarding your health and wellness. By sticking with the treatment plan that your doctor has come up with you, you will feel better over time and take back your health as well.
Dr. Alex Jimenez, D.C., presents how adrenal insufficiencies can affect the hormone levels in the body. Hormones play a vital part in regulating body temperature and help function the vital organs and muscles. This 2-part series will examine how adrenal insufficiencies affect the body and its symptoms. In part 2, we will look at the treatment for adrenal insufficiencies and how many people can incorporate these treatments into their health and wellness. We refer patients to certified providers that include hormone treatments that relieve various issues affecting the body while ensuring optimal health and wellness for the patient. We appreciate each patient by referring them to associated medical providers based on their diagnosis when it’s appropriate to understand better what they are feeling. We understand that education is an excellent and inquisitive way to ask our providers various intricated questions at the patient’s request and knowledge. Dr. Alex Jimenez, D.C., utilizes this information as an educational service. Disclaimer
What Are Adrenal Insufficiencies?
Dr. Alex Jimenez, D.C., presents: Many factors can affect the body, whether eating habits, mental health, or lifestyle habits all play a role in maintaining hormone function in the body. Today, we will apply these common dysfunctional cortisol patterns that patients present when they go in for a daily examination. Most patients often come in and explain to their doctors that they are suffering from adrenal dysfunction because different symptoms are associated with various stages of adrenal dysfunction or HPA dysfunction. Now adrenal dysfunction or hypothalamic pituitary adrenal (HPA) dysfunction is when the adrenal glands are not producing enough hormone to regulate the body. This causes the body to go through different stages of adrenal dysfunction if it is not treated right this way, causing the body to deal with muscle and joint pain that a person hasn’t dealt with throughout their life.
Many doctors and healthcare providers use a systematic approach that can help many people address whether or not they have adrenal dysfunction in their bodies. Today, we will discuss the relationship between female hormones and mood disorders associated with adrenal dysfunction. When it comes to adrenal dysfunction associated with hormones, many people will often get medicated for mental illnesses like bipolar disease or depression when their hormones are imbalanced. When hormonal imbalances begin to affect women in their early fifties due to premenopause, the mental disorder would often worsens and cause many other overlapping issues that can affect their hormones and their bodies.
Adrenal Dysfunction Affect The Body
Dr. Alex Jimenez, D.C., presents: Many women would have healthy diets, take yoga, be involved in spiritual practices, and hang out with their friends; however, when their hormone levels are imbalanced, they are dealing with other issues associated with HPA imbalances or adrenal dysfunction. By looking at the 24-hour corticotropic activity and determining how the circadian rhythm controls it, many doctors can look at the data presented to the patient. The way the data is being presented to the patient on how their hormone levels fluctuate in the body in the morning and how they rise or decrease throughout the entire day until they go to sleep.
With this information, many doctors can diagnose why this individual is having trouble going to sleep, constantly waking up early in the night, or not getting enough rest, making them exhausted throughout the day. So how is adrenal dysfunction associated with 24-hour corticotropic activity? Many factors can cause adrenal dysfunction in the body and affect hormone levels. When the body begins to over or underproduces hormones from the adrenal glands or the thyroids, it can cause cortisol and insulin levels to lose control in the body and cause various issues that result in muscle and joint pain. Sometimes hormonal dysfunction can cause somato-visceral or visceral-somatic pain by affecting the vital organs like the gut and the brain and start to cause issues to the surrounding muscles and joints. When the surrounding muscles and joints are causing pain in the body, they could be causing overlapping issues that can affect a person’s mobility and make them miserable.
How To Diagnose Adrenal Insufficiencies?
Dr. Alex Jimenez, D.C., presents: When doctors diagnose a patient suffering from adrenal dysfunction will begin to look at the patient’s medical history. Many patients will start filling out a long, extensive questionnaire, and doctors will begin to look at the anthropometrics, biomarkers, and clinical indicators found in physical exams. Doctors must obtain the patient’s history to look for the signs and symptoms of HPA dysfunction and adrenal dysfunction to determine the issue affecting the individual. After the examination, doctors would use functional medicine to look at where the dysfunction lies in the body and how the symptoms are connected. The numerous factors causing adrenal dysfunction in the body could be how a person’s eating habits are causing these issues, how much exercise they are incorporating in their daily lives, or how stress impacts them.
Functional medicine provides a holistic approach that considers lifestyle components causing issues in the person’s body. By connecting the dots on what the patient is saying and how these factors are causing adrenal insufficiencies, it is important to get the whole story from the patient to devise a treatment plan catered to the individual. They would appreciate that someone finally understands what they are going through and will begin to restore their health and wellness. By looking for the root causes, triggers, and mediators causing adrenal dysfunction, we can look at the expanded history that the patient is telling us, whether it be their family history, their hobbies, or what they like to do for fun. All these things are important to consider to try and connect the dots of the underlying cause of adrenal insufficiencies in the body affecting a person’s hormone levels.
Adrenal Insufficiencies Affect Cortisol
Dr. Alex Jimenez, D.C., presents: Now, do adrenal insufficiencies correlate with increased DHEA and cortisol hormone levels? Well, DHEA is a hormone that is produced by the adrenal glands naturally. DHEA’s main function is to make other hormones like estrogen and testosterone to regulate the male and female body. Cortisol is a stress hormone that increases the glucose levels in the bloodstream. Cortisol’s main function is to allow the brain to use glucose in the body while repairing the affected muscle tissues. When the body begins to over or underproduces hormones from the adrenal glands, it can raise the cortisol levels to cause resilience to the body, and the HPA axis begins to decrease. When this happens, the body starts to feel sluggish, which can cause you to feel exhausted throughout the entire day, even though you may have gotten a good night’s sleep.
Adrenal Insufficiency Symptoms
Dr. Alex Jimenez, D.C., presents: This is known as adrenal fatigue and can be associated with various symptoms that affect the hormone balance in the body. This can include non-specific symptoms like sleep disturbances, digestive issues, fatigue, and body aches can affect the hormone levels inside the body. This causes many individuals to feel miserable due to feeling low energy. Adrenal fatigue can also be associated with the different stages of HPA axis dysfunction. These can include:
Trauma
Food allergies and sensitivities
Dysbiosis
Changes in the gut microbiota
Toxins
Stress
Insulin resistance
Metabolic syndrome
All these issues can affect a person’s hormone levels and cause elevated cortisol to overlap many factors that cause somato-visceral problems. An example would be someone having gut issues associated with chronic stress who can start to feel pain in their joints from the knees, back, and hips which cause their hormone levels can fluctuate.
Dr. Alex Jimenez, D.C., presents an insightful overview of how hormonal dysfunction can affect the body, increase cortisol levels, and be associated with PTSD in this 3-part series. This presentation provides important information to many individuals dealing with hormonal dysfunction associated with PTSD. The presentation also offers different treatment options to reduce the effects of hormonal dysfunction and PTSD through functional medicine. Part 1 looks at the overview of hormonal dysfunction. Part 2 will look at how various hormones in the body contribute to body functionality and how overproduction or underproduction can cause drastic effects on a person’s health. We refer patients to certified providers that incorporate various hormone treatments to ensure optimal health and wellness for the patient. We appreciate each patient by referring them to associated medical providers based on their diagnosis when it is appropriate to have a better understanding. We understand that education is an excellent and inquisitive way to ask our providers various intricated questions at the patient’s request and knowledge. Dr. Alex Jimenez, D.C., utilizes this information as an educational service. Disclaimer
A Look Into Hormonal Dysfunction
Dr. Alex Jimenez, D.C., presents: Now, looking into the exciting didactic here, we will discuss something rare but important to understand when looking at these steroid pathways. And this is something called congenital adrenal hyperplasia. Now, congenital adrenal hyperplasia can occur in the body through an inherited enzyme defect or 21 hydroxylases that can cause a severe decrease in the adrenal production of glucocorticoids. When the body is suffering from congenital adrenal hyperplasia, it can cause an increase in ACTH to make more cortisol.
So when the ACTH increases to make more cortisol in the body, it could lead to muscle and joint pain if it is not treated immediately. We also often think cortisol is bad, but you must have some congenital adrenal hyperplasia when you have the 21 hydroxide deficiency. To that point, your body is not making enough glucocorticoids, causing you to have a high level of ACTH. When there is hormone dysfunction from various environmental triggers, it can cause the hormones in the body to overproduce unnecessary hormones. For example, if you have too much progesterone, it can’t go down to the pathway to make cortisol due to those missing enzymes. It can be converted into androstenedione, causing people to become virilized.
What Happens When The Body Doesn’t Create Enough Hormones?
Dr. Alex Jimenez, D.C., presents: So when patients become virilized, they’re not making any cortisol; it is important to do hormonal therapy to decrease the ACTH stimulation to get the hormone levels back to normal When this happens, it diminishes the stress inside the body system to make more androgens. In the female body, however, progesterone has no peripheral conversion of steroids to be produced except during pregnancy. Progesterone comes from the ovaries and doesn’t get to be produced in the adrenal glands. Progesterone is excreted mostly in urine as many different breakdown products tend to be higher than normal due to that 21 hydroxide deficiency.
So now, let’s talk about androgens in premenopausal women. So the major androgens come from the ovary, the DHEA, androstenedione, and testosterone. At the same time, the adrenal cortex produces glucocorticoids, mineralocorticoids, and sex steroids to make some testosterone and about half of the DHEA hormone. The body also has peripheral conversion responsible for DHEA and testosterone production to normalizing hormone levels. This is due to all the different tissues that have these enzymes to make these various hormones in different concentrations. Premenopausal women are most likely to lose more estrogen after removing their ovaries. This causes them to lose DHEA, androstenedione, and testosterone production in their bodies.
PTSD & Hormonal Dysfunction
Dr. Alex Jimenez, D.C., presents: Now testosterone is carried by SHBG just like estrogen, and many factors that change SHBG are important to testosterone and estrogen. Interestingly, testosterone can decrease SHBG in small amounts to allow the body to have free testosterone, which causes a physiological effect. When it comes to testing for testosterone levels, many people don’t release that when their testosterone levels are elevated, it could be due to low SHBG. By measuring total testosterone in the body, many doctors can determine if their patients are producing too much androgen, which is causing excessive hair growth in their bodies, or they may have low SHBG levels due to hypothyroidism associated with obesity or elevated insulin.
Now when it comes to PTSD, how does it correlate to hormonal dysfunction and affect the body? PTSD is a common disorder many individuals suffer from when they have been through a traumatic experience. When traumatic forces begin to affect the individual, it can cause the cortisol levels to rise and cause the body to be in a state of tension. PTSD symptoms can vary for many individuals; thankfully, various therapies can help lower the symptoms while bringing the hormone levels back to normal. Many healthcare professionals will develop a treatment plan that can help reduce the symptoms of PTSD and help hormone levels function in the body properly.
Treatments To Regulate Hormone
Dr. Alex Jimenez, D.C., presents: Stress in the body can affect the musculoskeletal system by causing the muscle to lock up, leading to issues in the hips, legs, shoulders, neck, and back. Various treatments like meditation and yoga can help lower the cortisol levels from fluctuating higher, causing the body to deal with muscle tension that could overlap with joint pain. Another way to reduce stress in the body is by working out with an exercise regime. Exercising or participating in an exercise class can help loosen up the stiff muscles in the body, and keeping a workout routine can exert any pent-up energy to relieve stress. However, treatments to balance out hormones associated with PTSD can only go so far for many individuals. Eating nutritional, whole foods with vitamins and minerals can help regulate hormone production and provide energy to the body. Dark leafy greens, fruits, whole grains, and proteins can not only help with regulating hormone production. Eating these nutritional foods can also lower inflammatory cytokines that are causing more harm to vital organs like the gut.
Conclusion
Incorporating a healthy diet, an exercise routine, and getting treatment can help many individuals dealing with hormonal dysfunction associated with PTSD. Each person is different, and the symptoms overlap with hormonal dysfunction associated with PTSD and vary from person to person. When doctors work with associated medical providers, it allows them to develop a treatment plan catered to the individual and enables them to regulate their hormone production. Once the hormone production in their bodies is regulated, the symptoms causing the person pain will get better slowly but surely. This will allow the individual to continue on their wellness journey.
Dr. Alex Jimenez, D.C., presents an overview of hormonal dysfunction can affect the various hormones in the body that can increase cortisol levels in this 3-part series. This presentation provides valuable information to many individuals dealing with hormonal dysfunction and how to know the signs and utilize holistic approaches toward their health wellness. Part 1 will look at the overview of hormonal dysfunction. Part 3 will look at various holistic treatments that are available for hormonal dysfunction. We refer patients to certified providers incorporating various hormone therapies to ensure optimal health. We encourage and appreciate each patient by referring them to associated medical providers based on their diagnosis when it is appropriate. We understand that education is an excellent way when asking our providers intricated questions at the patient’s request and understanding. Dr. Alex Jimenez, D.C., only utilizes this information as an educational service. Disclaimer
An Overview Of Hormonal Expression
Dr. Alex Jimenez, D.C., presents: So the classic teaching about hormones is that they’re produced in an endocrine gland and then transported to the cells where the body will utilize them. But things are a little bit more complex. So every cell contains the genes necessary for hormone expression and functionality in the body.
And we know this because when de-differentiated from the late stage, unfortunately, cancer cells uncover gene expression. Those cells make hormones in inappropriate locations and at inconvenient times. So that means that any cell can make any hormones in the body. Still, the hormonal expression of certain genes indicates the presence of certain enzymes, which determines what hormones will reproduce. So, for example, you need to have the right precursors and enzymes. So in a reproductive female, the granulosa cells, the luteinize, and the corpus luteum are produced in the body. The granulosa cells are follicles, while the corpus odium is after ovulation. And these cells start the formation of the steroid hormones in response to FSH and LH. So FSH and LH come from the pituitary glands and stimulate the granulosa cells to start making estrogen. Steroid production will begin if the messaging from FSH and LH gets to the part of the cell that makes estrogen. This allows the body to regulate hormonal production and keep it functional. When issues disrupt hormonal regulation, the body can over or underproduce hormonal production, leading to metabolic issues associated with muscle and joint pain.
So this is a complex process, and there are many areas where this can go wrong. So you can have the right amounts of the hormone, but you’re not getting hormone production. So the messages must get into the cell first, and FSH and LH are too large to get into the cellular structure. So, they have to activate a membrane-based enzyme called adenylate cyclase to produce cyclic AMP to enter the cellular network and start hormonal formation in the body. This is the P, or the production of hormones. So by thinking about cellular membrane health, if a doctor does an essential fatty acid analysis, the patients may be very low in omega-3s; therefore, their cell membranes are more rigid and affect the body’s hormonal process. When patients are not taking their omega-3s, it could cause the inflammatory cytokines to cause more joint pain issues when various factors affect the body internally. Since inflammation can be good or bad in the body, it can cause hormonal dysfunction when they attack healthy cellular structures. That will affect this hormonal production process.
Hormonal Production Process In The Body
Dr. Alex Jimenez, D.C., presents: Once made, estradiol goes directly into the blood and is not stored, but it’s bound to SHBG and albumin. And SHBG is changed by obesity and insulin associated with hypothyroidism. So when women are obese or hyperinsulinemic will have less SHBG or hypothyroidism to transport the estrogen to the cells. This tells the body that the hormones are no longer FSH or LH and cyclic AMP, but this is estrogen. And so, estradiol is sensitive since estradiol has to go in and have a cytoplasmic receptor. So the estrogen receptor is in the cytoplasm. After it binds to the receptor, it goes into the nucleus, and it’s transcribed and then goes back out and translated to allow the body to make proteins that cause cell proliferation. Estrogen is a proliferative hormone. And once it’s acted on the cell after proliferation, it’s degraded in the cell with heat shock proteins or released back into the circulation in the body’s system.
Let’s talk about some of the basics of biochemistry because the steroidogenic pathway n the body has different ways to reduce carbons in the body. The body’s system could convert it into estrone or estriol, with less estrogen in circulation. And then estradiol, estrone, estriol, everything is eliminated through the detoxification pathways. So in the Living Matrix, healthy detoxification and estrogen metabolism pathways help the body stay functional. When the body goes through detoxification, it helps reduce the issues by figuring out what is causing the problems affecting the body’s system and slowing introducing or taking away the pain that can allow normal hormonal regulation. When the body reduces excessive carbon, it can lower cholesterol from reaching dangerous levels.
Cholesterol & Hormones
Dr. Alex Jimenez, D.C., presents: So it all starts with cholesterol, and the body can’t make enough cholesterol, so we consume food to allow it to enter the body and begin to biotransform into LDL (low-density lipoprotein) to initiate steroid hormone synthesis. So we need LDL in the body to decrease the carbons since it is a union directional. When it comes to hormone deficiency cases, sometimes women can come in with extremely low LDLs because they’re on statins, underweight, or over-athletic; these are connections and pattern recognition. In a female’s body, the ovaries on the left and right side of the female reproduction system produce all three sex steroids: estrogens, progesterones, and androgens, for optimal body function. They are different than the male’s reproduction system, which includes the testicles, due to the other enzymes. They differ from the testes in many ways due to additional hormonal output in the body, which is different than adrenal hormones. For example, if the body can’t make aldosterone or cortisol in the endocrine glands, they will be shunted to make sex hormones. And since each body is diverse, male or female, some hormones can’t make glucocorticoids or mineral corticoids.
So we must think about mitochondrial health for hormone production, which is critical for producing hormones. For expecting mothers, it allows the formation of pregnancy alone in the mitochondria. So mitochondrial health energy is related to hormone health, which causes cholesterol uptake by the mitochondria in the adrenal glands and ovaries that can stimulate ACTH. So the mitochondria can make hormones as we go while enabling the enzymes in the female’s body to induce pregnenolone formation. However, getting the cholesterol to the inner membrane and LDL to the inner membrane to the mitochondria is the rate-limiting step in all steroid hormone synthesis. Now it can develop and go into two different pathways in the body. It can create DHEA, or it can include progesterone when cholesterol is forming pregnenolone and can look diagrammatically in test results.
DHEA & Hormones
Dr. Alex Jimenez, D.C., presents: So if the mitochondria can enable the body’s pregnenolone to form DHEA or progesterone, let’s start with going over things with developing progesterone since it’s hydroxylated. It creates an enzyme called 17 hydroxy progesterone, the immediate precursor of the androgens and estrogens. So the 17 hydroxy progesterone will eventually form androgens or estrogens, and androstenedione can develop testosterone, and both can become estrogens by aromatization. So what does this mean? It means you must be concerned about too many androgens being around because they can become estrogen. The best way to remember this is that androstenedione can become estrone, and testosterone can become estradiol. This can cause progesterone to be the precursor to cortisol in the body and can go in two different directions.
So progesterone is also the precursor to aldosterone, which asks what will happen when the body needs cortisol or aldosterone. The body will then produce less progesterone causing it to be shunned in hormonal production and causing cortisol to overproduce. This is known as cortisol steal, and if it is not treated at the moment, it can cause muscle and joint inflammation in the body, leading to various issues that the person is dealing with.
A decreased formation of androgens and estrogens can inhibit the DHEA pathway. So when the body makes more cortisol, it can cause the hormones to develop an estrogen-dominate shape causing the cortisol hormone to stimulate aromatase. To that point, it can lead to breast cancer, fibroids, and endometriosis in the long term. Women can get stress, hot flashes, and decreased libido due to that hormonal decrease in their bodies.
Conclusion
Other issues like stress can cause increased cortisol formation, anxiety, inflammation, simple carbohydrates, et cetera to the body associated with joint and muscle pain. They can also inhibit sex and sex hormone production directly and indirectly. So this is where people have to be concerned if they’re giving DHEA because DHEA can convert itself into sex hormones. So that can be a good thing if you’re dealing with hormonal deficiency. But if you give too much DHEA, you can overproduce hormonal function.
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