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The Importance of Folate and Folic Acid

The Importance of Folate and Folic Acid

Folate is a B vitamin naturally found in a variety of foods. The body can’t produce folate, that’s why it’s important to get it from folate-rich foods. Folate is naturally found in various plant and animal foods, including citrus fruits, avocado, spinach, kale, broccoli, eggs, and beef liver. Folate is also added to foods, such as bread, flours, and cereals, in the form of folic acid or the synthetic, water-soluble version of folate. Folate and folic acid have different effects on the body.

 

Our body utilizes folate for a variety of essential functions, including cell division, development of red blood cells, conversion of homocysteine to methionine, an amino acid used for protein synthesis, production of SAMe, and DNA methylation. Folic acid is also important for various metabolic processes. Folate deficiency has ultimately been associated with a variety of health issues, such as the increased risk of heart disease, birth defects, megaloblastic anemia, and cancer.

 

Daily Intake of Folate and Folic Acid

 

Our body stores between 10 to 30 mg of folate, most of which is stored in your liver while the remaining amount is stored in your blood and tissues. Normal blood folate levels range from 5 to 15 ng/mL. The main form of folate in the bloodstream is known as 5-methyltetrahydrofolate. Daily intake of this essential nutrient is different for people of different ages. The recommended daily allowance of folate for infants, children, teens, adults, and pregnant women are as follows:

 

  • 0 to 6 months: 65 mcg
  • 7 to 12 months: 80 mcg
  • 1 to 3 years: 150 mcg
  • 4 to 8 years: 200 mcg
  • 9 to 13 years: 300 mcg
  • over 14 years: 400 mcg
  • during pregnancy: 600 mcg
  • during lactation: 500 mcg

 

Folic acid supplements play an important role in making sure that people who are in greater need of folate are getting enough of their daily intake. Increasing the daily intake of folate-rich foods is also important because these foods generally offer plenty of other nutrients that all act together to support overall health. Recommended folate daily intake increases during pregnancy and breastfeeding to promote rapid growth and help prevent neural tube defects in the fetus.

 

Folic acid is available in dietary supplements and fortified foods, including bread, flours, cereals, and several types of grains. It is also added to B-complex vitamins. Folate is also naturally found in a variety of foods, including:

 

  • oranges
  • orange juice
  • grapefruit
  • bananas
  • cantaloupe
  • papaya
  • canned tomato juice
  • avocado
  • boiled spinach
  • mustard greens
  • lettuce
  • asparagus
  • Brussels sprouts
  • broccoli
  • green peas
  • black-eyed peas
  • dry-roasted peanuts
  • kidney beans
  • eggs
  • Dungeness crab
  • beef liver

 

Uses of Folate and Folic Acid

 

Both folate and folic acid are frequently utilized for a variety of reasons. Although folate and folic acid supplements are generally used to treat similar health issues, they do offer different effects in the body and, therefore, it may affect our overall health in different ways. Moreover, getting the proper daily intake of folate and folic acid can improve overall health. The following are several of the most common uses of folate and folic acid supplements, including:

 

  • folate deficiency
  • inflammation
  • diabetes
  • brain health
  • heart disease
  • kidney disease
  • mental health issues
  • fertility problems
  • birth defects and pregnancy complications

 

For information regarding the importance of folate and folic acid, please review the following article:

The Importance of Folic Acid

 


 

 

Folate is a B vitamin that is naturally found in many different types of food. Because we can’t produce folate, it’s important to get it from foods that are high in folate. Various folate-rich foods include citrus fruits, avocado, spinach, kale, broccoli, eggs, and beef liver. Folate is also added to foods like bread, flours, and cereals, in the form of folic acid, the synthetic version of this essential nutrient. Folate and folic acid have different effects on the body. Our body uses folate for many important functions, including cell division, development of red blood cells, conversion of homocysteine to methionine, an amino acid used for protein synthesis, production of SAMe, and DNA methylation. Folic acid is also essential for many metabolic processes. Folate deficiency has ultimately been associated with a variety of health issues, such as heart disease, birth defects, megaloblastic anemia, and even cancer. Daily intake of this essential nutrient is different for people of different ages. Furthermore, folate is also naturally found in a variety of foods, such as bananas, avocado, boiled spinach, and eggs. Both folate and folic acid supplements have a variety of uses and they can help improve various health issues, including inflammation, diabetes, heart disease, birth defects, and pregnancy complications. Adding healthy foods to a smoothie is a fast and easy way to get your daily intake of folate. – Dr. Alex Jimenez D.C., C.C.S.T. Insight

 


 

Image of ginger greens juice.

 

Ginger Greens Juice

Servings: 1
Cook time: 5-10 minutes

� 1 cup pineapple cubes
� 1 apples, sliced
� 1-inch knob of ginger, rinsed, peeled, and chopped
� 3 cups kale, rinsed, and roughly chopped or ripped
� 5 cups Swiss chard, rinsed, and roughly chopped or ripped

Juice all ingredients in a high-quality juicer. Best served immediately.

 


 

Image of soft-boiled and hard-boiled eggs.

 

Eating cholesterol-rich foods doesn�t increase your cholesterol

 

According to research studies, eating foods with HDL cholesterol or “good” cholesterol doesn’t increase your overall blood cholesterol levels. When you eat healthy cholesterol-rich foods, such as prawns and eggs, your blood cholesterol levels decrease, so your blood cholesterol levels stay balanced, or they’re only raised minimally. It’s actually saturated fats that you have to look out for when it comes to high blood cholesterol levels. Simply choose healthier food options.

 


 

The scope of our information is limited to chiropractic, musculoskeletal, physical medicines, wellness, and sensitive health issues and/or functional medicine articles, topics, and discussions. We use functional health & wellness protocols to treat and support care for injuries or disorders of the musculoskeletal system. Our posts, topics, subjects, and insights cover clinical matters, issues, and topics that relate and support directly or indirectly our clinical scope of practice.* Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. We understand that we cover matters that require an additional explanation as to how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900. The provider(s) Licensed in Texas*& New Mexico*�

 

Curated by Dr. Alex Jimenez D.C., C.C.S.T.

 

References:

 

  • Kubala, Jillian. �Folic Acid: Everything You Need to Know.� Healthline, Healthline Media, 18 May 2020, www.healthline.com/nutrition/folic-acid#What-is-folic-acid?
  • Ware, Megan. �Folate: Health Benefits and Recommended Intake.� Medical News Today, MediLexicon International, 26 June 2018, www.medicalnewstoday.com/articles/287677#recommended-intake.
  • Felman, Adam. �Folic Acid: Importance, Deficiencies, and Side Effects.� Medical News Today, MediLexicon International, 11 Mar. 2020, www.medicalnewstoday.com/articles/219853#natural-sources.
  • Berg, M J. �The Importance of Folic Acid.� The Journal of Gender-Specific Medicine: JGSM: the Official Journal of the Partnership for Women’s Health at Columbia, U.S. National Library of Medicine, June 1999, pubmed.ncbi.nlm.nih.gov/11252849/.
  • Dowden, Angela. �Coffee Is a Fruit and Other Unbelievably True Food Facts.� MSN Lifestyle, 4 June 2020, www.msn.com/en-us/foodanddrink/did-you-know/coffee-is-a-fruit-and-other-unbelievably-true-food-facts/ss-BB152Q5q?li=BBnb7Kz&ocid=mailsignout#image=23.

 

What is Folate Metabolism?

What is Folate Metabolism?

Folate, and its synthetic form folic acid, is a water-soluble B vitamin that plays a fundamental role in a variety of functions in the human body. Folate is essential for cell division and homeostasis because it acts as a coenzyme in many biological pathways, including amino acid metabolism, methionine production, and DNA methylation. Folate metabolism happens together with the methionine cycle and the choline pathway. Most folate coenzymes are found in the liver.

 

Folate is also used as a coenzyme to convert methionine into homocysteine. Vitamin B6 and B12, together with folate, are also essential for DNA synthesis. Proper dietary intake of folate is fundamental for normal cell growth and DNA repair. Folate or vitamin B12 deficiency can ultimately cause a variety of health issues, including anemia. Oral supplementation may be necessary. In the following article, we will discuss folate metabolism and foods that are high in folate.

 

Folate Metabolism Overview

 

Several of the most important functions of folate metabolism are methylation and S-adenosylmethionine (SAM) production, one of the most essential methyl donors in the cell. In the following diagram, we will explain folate metabolism.�

 

Image of a folate metabolism diagram.

 

Figure 1: One carbon metabolism. ATP: adenosyl triphosphate, B6: vitamin B6, B12: vitamin B12, BHMT: betaine homocysteine methyltransferase, CBS: cystathionine-?-synthase, DHF: dihydrofolate, DMG: dimethylglycine, dTMP: deoxythymidine monophosphate, dUMP: deoxyuridine monophosphate, Gly: glycine, Hcy: homocysteine, MAT: methionine adenosyltransferase, Met: methionine, MCM: L-methylmalonyl CoA mutase, MM-CoA: L-methylmalonyl CoA, MMA: methylmalonic acid, MS: methionine synthase, MTHFR: 5,10-methyltetrahydrofolate reductase, SAH: S-adenosyl homocysteine, SAHH: S-adenosyl homocysteine hydrolase, SAM: S-adenosyl methionine, Ser: serine, SHMT, serine hydroxymethyltransferase, THF: tetrahydrofolate, TS: thymidylate synthase. Adapted from: Hypo- and hypervitaminosis of B and D vitamins � Diagnosis and clinical consequences. Herrmann W. et al. 2013. Uni-Med Verlag AG.

 

Dihydrofolate reductase (DHFR) is a component that converts folate to dihydrofolate (DHF) and DHF to the active form, THF. Folate metabolism consists of three cycles. One cycle starts with a component known as 10-formylTHF which is associated with purine production and two cycles utilize 5, 10-methyleneTHF in deoxythymidine monophosphate (dTMP) and methionine production. 5-MethylTHF is one of the most predominant forms of folate found in the human body.

 

After cellular uptake, 5-methylTHF is converted into THF through the use of vitamin B12 in methionine synthase (MS). The methionine cycle is a fundamental pathway in SAM production. As previously mentioned above, B vitamin deficiencies, including folate, vitamin B6, and B12, as well as genetic birth defects can ultimately cause a variety of health issues. 5,10-MethyleneTHF is finally converted to 5-methylTHF by 5,10-methylenetetrahydrofolate reductase (MTHFR).

 

Several of the most important functions of folate metabolism are methylation and S-adenosylmethionine (SAM) production, one of the most essential methyl donors in the cell. In the following diagram, we will simplify folate metabolism.�

 

Image of a second folate metabolism diagram.

 

15 Foods That Are High in Folate

 

Folate, and its synthetic form folic acid, is a water-soluble B vitamin that plays a fundamental role in a variety of functions in the human body. It�supports cell division and promotes fetal growth and development to reduce the risk of genetic birth defects. Folate is naturally found in many different types of foods. Doctors recommend 400 mcg of folate every day for adults to prevent deficiency. Here are 15 healthy foods that are high in folate or folic acid, including:

 

  • avocado
  • bananas
  • citrus fruits
  • papaya
  • beets
  • leafy greens
  • asparagus
  • Brussels sprouts
  • broccoli
  • nuts and seeds
  • legumes
  • eggs
  • beef liver
  • wheat germ
  • fortified grains

 

In conclusion, folate, and its synthetic form folic acid, is an important micronutrient that can be naturally found in many different types of foods. Eating many different types of healthy foods, including fruits, vegetables, nuts, and seeds, as well as fortified foods, is an easy way to increase your folate intake. These foods are not only high in folate but these are also high in other essential nutrients that can ultimately improve other aspects of your overall health.

 

For information regarding the nutritional role of folate, please review the following article:

Nutritional Role of Folate

 


 

Folate or folic acid is a water-soluble B vitamin that plays a fundamental role in a variety of functions in the human body, including cell division and homeostasis. Folate also helps with amino acid metabolism, methionine production, and DNA methylation.�Folate or vitamin B12 deficiency can ultimately cause a variety of health issues. Oral supplementation may be necessary. In the diagrams above, we explain the process of folate metabolism.�Folate is naturally found in many different types of foods, including avocado, citrus fruits, leafy greens, broccoli, nuts and seeds, legumes, eggs, and fortified grains.�Eating many different types of healthy foods is an easy way to increase your folate intake. These foods are not only high in folate but these are also high in other essential nutrients that can ultimately improve other aspects of your overall health.�- Dr. Alex Jimenez D.C., C.C.S.T. Insights

 


 

Image of the Berry Bliss Smoothie

 

Berry Bliss Smoothie

Servings: 1
Cook time: 5-10 minutes

� 1/2 cup blueberries (fresh or frozen, preferably wild)
� 1 medium carrot, roughly chopped
� 1 tablespoon ground flaxseed or chia seed
� 1 tablespoons almonds
� Water (to desired consistency)
� Ice cubes (optional, may omit if using frozen blueberries)

Blend all ingredients in a high-speed blender until smooth and creamy. Best served immediately.

 


 

Image of Almonds.

 

Almonds have twice as much calcium as milk

 

Gram for gram this is absolutely true! According to McCance and Widdowson’s Composition of Foods (the official guide to the nutrients in food used in the UK), about 100g of almonds have 240mg of bone-building calcium while semi-skimmed (2%) milk has 120mg per 100g (3.5oz). With that being said, however, we tend to drink milk in bigger quantities than we eat almonds (and the calcium from milk is easily absorbed), so the dairy option may be a better source day-to-day.

 


 

The scope of our information is limited to chiropractic, musculoskeletal, physical medicines, wellness, and sensitive health issues and/or functional medicine articles, topics, and discussions. We use functional health & wellness protocols to treat and support care for injuries or disorders of the musculoskeletal system. Our posts, topics, subjects, and insights cover clinical matters, issues, and topics that relate and support directly or indirectly our clinical scope of practice.* Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. We understand that we cover matters that require an additional explanation as to how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900. The provider(s) Licensed in Texas*& New Mexico*�

 

Curated by Dr. Alex Jimenez D.C., C.C.S.T.

 

References:

 

  • Almas, Saneea. �Folic Acid: An Overview of Metabolism, Dosages, and Benefits of Optimal Periconception Supplementation: InfantRisk Center.� Infant Risk Center, Texas Tech University Health Sciences Center, www.infantrisk.com/content/folic-acid-overview-metabolism-dosages-and-benefits-optimal-periconception-supplementation.
  • Homocysteine Expert Panel Staff. �Folate Metabolism.� Homocysteine Expert Panel, Homocysteine Expert Panel Media, www.homocysteine-panel.org/en/folatefolic-acid/basics/folate-metabolism/.
  • Link, Rachael. �15 Healthy Foods That Are High in Folate (Folic Acid).� Healthline, Healthline Media, 27 Feb. 2020, www.healthline.com/nutrition/foods-high-in-folate-folic-acid.
  • Shuhei, Ebara. �Nutritional Role of Folate.� Congenital Anomalies, U.S. National Library of Medicine, 11 June 2017, pubmed.ncbi.nlm.nih.gov/28603928/?from_term=folate%2Bmetabolism&from_pos=3.
  • MSN Lifestyle Staff. �Coffee Is a Fruit and Other Unbelievably True Food Facts.� MSN Lifestyle, MSN Lifestyle Media, 4 June 2020, www.msn.com/en-us/foodanddrink/did-you-know/coffee-is-a-fruit-and-other-unbelievably-true-food-facts/ss-BB152Q5q?li=BBnb7Kz&ocid=mailsignout#image=5.