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Filling the Fridge With Flavonoids

Filling the Fridge With Flavonoids

Do you feel:

  • Crave sweets during the day
  • Eating sweets does not relieve the sugar craving
  • Waist girth is equal or larger than hip girth
  • Difficulty losing weight
  • Feel shaky, jittery or have tremors

If you are experiencing any of these situations, then try eating flavonoid filled foods to regulate your metabolic health.


Going to the grocery store is an excellent way to restock on certain food items and getting food that is filled with flavonoids. Nearly all fruits and vegetables are filled with this chemical component and are proven to be beneficial to the body. Flavonoids are a class of plant-derived polyphenolic compounds that represents a larger class of phytochemicals and phytonutrients. They are responsible for protecting plants from threats like insects and animals, while also having many beneficial health effects on metabolic disorders in humans.

With their chemical structure, they are group into six primary subclasses: anthocyanins, flavanols, flavan-3-ols, flavanones, flavones, and isoflavones. They concentrated more on the skins and seeds of plants, and when they are consumed into the body, they have antioxidant and anti-inflammatory properties.

Heart Disease and Cancer

Flavonoid-rich foods have been linked to many health benefits and have been known to protect the body against heart disease and cancer. A recent study stated that individuals who consume a moderate to the high amount of flavonoid-rich foods have the lowest risk of developing cardiovascular diseases and cancer mortality. Individuals who are heavy alcohol users and cigarette smokers have a higher risk of developing these chronic illnesses.

Flavonoid Beneficial Effects on Metabolic Health

Studies provided evidence that flavonoids from citrus fruits possess serval biological activities and have emerged as efficient therapeutics for the treatment of CVD (cardiovascular disease). Citrus flavonoids can scavenge free radicals, improve glucose tolerance and insulin sensitivity, modulate lipid metabolism, and adipocyte differentiation, suppress inflammation and apoptosis, and improve endothelial dysfunction.

A journal review demonstrated how natural-occurring flavonoids could prevent diabetes and its many complications. Flavonoids can target specific molecules that are involved in regulating pathways that support beta-cell proliferation, insulin signaling and secretion, reducing apoptosis, regulating glucose metabolism in the liver, improving carbohydrate digestion, glucose uptake, and deposition in the body. In human nutrition, quercetin (the most abundant dietary flavonoid) was shown to stimulate GLUT4 translocation to the molecular signaling that sets the motion during muscle contractions in the body.

Another study summarized that the role of flavonoid in metabolic diseases was able to elevate the energy system by activating the sympathetic nervous system, increasing epinephrine and thyroid hormone release, stimulating thermogenesis, and induce browning of� WAT (white adipose tissue). Browning WAT and up-regulating BAT (brown adipose tissue) can help increase the energy expenditure and improves lipids and glucose metabolism. When this happens, flavonoids stimulate the AMPK-PGC-1?, Sirt1, and PPAR? signaling pathways. These critical pathways are involved in preventing obesity and metabolic derangement due to their role in energy metabolism in the body.

Flavonoids Prevent Neuroinflammation

Blueberries are an excellent source of flavonoids that may help brain function in older adults. They have protective effects against the development of neurocognitive disorders like Alzheimer’s and other dementia diseases. Studies have shown that anthocyanins have the responsibility for improving cognitive function and working memories on the individual�s brain.

Studies have been shown that flavonoids target astrocytes, and these are star-shaped glial cells of the CNS (central nervous system). When they are healthy, they are crucial for functional control of the CNS since they are the primary cells that are responsible for neurotropic growth, synaptic plasticity, neurogenesis, cell migration, and differentiation. When glial cells are overactivated and dysfunctional, they are associated with the pathogenesis of brain diseases and cancers, hence why flavonoid therapy is a safe treatment of brain pathologies.

Sources of Flavonoids

Flavonoids are easily attainable through eating plant-based foods and beverages. Fruits, vegetables, tea, dark chocolate, and red wine are great examples because they are filled with not only flavonoids, but they also contain anti-inflammatory and antioxidants properties. The phrase “eat the rainbow” takes a whole new meaning for anyone who is trying to eat healthier. Colorful foods with deep reds, purples, oranges, yellows, greens, blues, and black hues are filled with flavonoids. Health professionals often recommend that it is best to avoid white foods that lack nutrients like refined bread, pasta, and sugars. However, white/tan-colored foods like garlic, cauliflower, mushrooms, ginger, onions, and parsnips offer oxidant-fighting properties that are perfect for getting rid of free radicals in the body.


Flavonoids are a class of plant-derived polyphenolic compounds that is in a variety of fruits and vegetables that are easily attainable for anyone to eat. When it is consumed into the body, it has many beneficial health effects on the body. They contained anti-inflammatory and antioxidants that the body needs to fight off free radicals that may have entered the body through environmental factors. Some products can be paired with flavonoid foods that can offer metabolic support as well as supporting the body’s sugar metabolism. So go out and eat the flavonoid food rainbow.

October is Chiropractic Health Month. To learn more about it, check out Governor Abbott�s proclamation on our website to get full details on this historic moment.

The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or chronic disorders of the musculoskeletal system. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .


Aron, Patricia M, and James A Kennedy. “Flavan-3-Ols: Nature, Occurrence, and Biological Activity.” Molecular Nutrition & Food Research, U.S. National Library of Medicine, Jan. 2008,

Barreca, Davide, et al. �Flavanones: Citrus Phytochemical with Health-Promoting Properties.� BioFactors (Oxford, England), U.S. National Library of Medicine, 8 July 2017,

Bondonno, Nicola P, et al. �Flavonoid Intake Is Associated with Lower Mortality in the Danish Diet Cancer and Health Cohort.� Nature Communications, Nature Publishing Group UK, 13 Aug. 2019,

Cannon, Barbara, and Jan Nedergaard. �Brown Adipose Tissue: Function and Physiological Significance.� Physiological Reviews, U.S. National Library of Medicine, Jan. 2004,

Erdman, John W, et al. �Effects of Cocoa Flavanols on Risk Factors for Cardiovascular Disease.� Asia Pacific Journal of Clinical Nutrition, U.S. National Library of Medicine, 2008,

Lila, Mary Ann. �Anthocyanins and Human Health: An In Vitro Investigative Approach.� Journal of Biomedicine & Biotechnology, Hindawi Publishing Corporation, 2004,

Mahmoud, Ayman M, et al. �Beneficial Effects of Citrus Flavonoids on Cardiovascular and Metabolic Health.� Oxidative Medicine and Cellular Longevity, Hindawi, 10 Mar. 2019,

Matias, Isadora, et al. �Functions of Flavonoids in the Central Nervous System: Astrocytes as Targets for Natural Compounds.� Neurochemistry International, Pergamon, 2 Feb. 2016,

Panche, A N, et al. �Flavonoids: an Overview.� Journal of Nutritional Science, Cambridge University Press, 29 Dec. 2016,

Richter, Erik A, and Mark Hargreaves. �Exercise, GLUT4, and Skeletal Muscle Glucose Uptake.� Physiological Reviews, U.S. National Library of Medicine, July 2013,

Team, DFH. �Stock Your Fridge with Flavonoids.� Designs for Health, 1 Oct. 2019,

Trayhurn, P, and J H Beattie. �Physiological Role of Adipose Tissue: White Adipose Tissue as an Endocrine and Secretory Organ.� The Proceedings of the Nutrition Society, U.S. National Library of Medicine, Aug. 2001,

Yu, Jie, et al. �Isoflavones: Anti-Inflammatory Benefit and Possible Caveats.� Nutrients, MDPI, 10 June 2016,





Can Flavonoids Reduce Cardiovascular Disease? | Wellness Clinic

Can Flavonoids Reduce Cardiovascular Disease? | Wellness Clinic

Diets high in flavonoids have been associated with a way of life, as it’s often a part of many nutritional recommendations from healthcare professionals associated with the prevention of chronic diseases. However, the identification of beneficial effects from flavonoids and flavonoid-rich foods has become a difficult area to discuss due to a conditional or non-essential role of flavonoids in human nourishment, according to some research.


Do flavonoids help reduce the risk of cardiovascular disease?


Nonetheless, recent attempts to otherwise prove this in the medical field surrounding cardiovascular disease as well as efforts in the area of high flavonoid containing foods, have started supplying the demonstrations of effects and mechanisms of action in well-controlled research studies. Further studies are essential for confirmation of the effects and for the proper identification of bioactive flavonoids in relation to cardiovascular diseases.


Flavonoids and Cardiovascular Disease


Epidemiological studies, clinical trials and basic science has found an inverse correlation between flavonoid intake and a decreased mortality from the prevalence of stroke and coronary heart disease, including the improvement of hypertension and cardiovascular disease risks.


More than 4000 naturally occurring flavonoids have been identified, including fruits, vegetables, red wine, tea, soy and licorice. Flavonoids (flavonols, flavones and isoflavones) are potent free radical scavengers that inhibit lipid peroxidation, prevent atherosclerosis, promote vascular relaxation and also have anti-hypertensive properties. Along with reducing stroke and providing effects which reduce mortality and CHD morbidity, as mentioned.


Many mechanisms have been suggested to explain the protective effects of flavonoids in relation to cardiovascular diseases:


Antiatherogenic effects. Flavonoids along with other antioxidants, comprise two lines of defense in protecting cells from harm because of oxidation of LDL cholesterol; First, in the LDL blood cholesterol level, by inhibiting LDL oxidation because of their free radical scavenger activity, and second, in the cellular level, by shielding the cells accordingly, i.e., by raising their resistance against the cytotoxic effect of oxidised LDL. Recent research studies suggest that flavonoids may additionally help stop the expression of adhesion and chemoattractant molecules.


Antiaggregant effects. Flavonoids avoid platelet aggregation triggered by numerous pro-aggregant stimuli although high doses are required. Inhibition of platelet phosphodiesterases, inhibition of arachidonic acid metabolism and antioxidant effects have been suggested as potential mechanisms of action.


Direct effects on vascular smooth muscle. The vasodilator effects of flavonoids in vitro is endothelium-independent. The most important mechanism appears to be related to their inhibitory effects on protein kinases. Some flavonoids, though, can produce endothelium-dependent contractile reactions due to increased TXA2, or thromboxane A2, production.


Anti-hypertensive results.�Only small amounts of information concerning the effects of flavonoids on blood pressure have been obtained. However, recently, the oral administration of quercetin has been shown to exert potent anti-hypertensive effects


Resveratrol is a potent antioxidant and anti-hypertensive, found from red wine and in the skin of grapes. Administration to individuals enhances compliance, reduces enhancement indicator and enhances blood pressure when administered as 250 mL of either�regular or de-alcoholized red wine. There was a substantial reduction in the aortic augmentation index of 6.1 percent together with all the de-alcoholized red wine and 10.5 percent with regular red wine. The central blood pressure was significantly reduced by de-alcoholized red wine in 7.4 mmHg and 5.4 mmHg by routine red wine. Resveratrol improves ED circulation mediated vasodilation at a dose related manner, prevents uncoupling of eNOS, increases adiponec-tin, lowers HS-CRP and blocks the effects of angiotensin II. The suggested dose is 250 mg/d of transresveratrol.


Research on CVD and Flavonoids


Basic science, clinical monitoring, and a variety of research studies, have all led to an emerging body of evidence on the role of flavonoids, at the prevention of cardiovascular disease. However, the existing studies on flavonoids or its food resources have provided contradictory results,�generally on the primary prevention of coronary heart disease mortality. The study used the grant mechanism to analyze data that was previously collected.


The researchers examined whether flavonoid intake was associated with the risk of incident cardiovascular disease and whether specific food sources of flavonoids, including onions, tea, apples, red wine, along with other foods, have been related to the risk of CVD and hypertension. The researchers processed and examined previously collected statistics of 39,876 middle-aged and elderly girls free of CVD; the Women’s Antioxidant Cardiovascular Study (WACS), a prospective study of 8,171 middle-aged and older women with preexisting CVD or over three coronary risk factors; the Normative Aging Study (NAS), a prospective study of 2,280 middle-aged and elderly men; along with the Boston Area Health Study (BAHS), a case-control study of first nonfatal myocardial infarction in women and men aged less than 76 decades. Utilizing data from semiquantitative food frequency questionnaires administered in every study, the investigators determined individual intake of flavonoids and its food sources.


Unlike previous studies, researchers have examined flavonoids in relation to both primary and secondary prevention of cardiovascular disease, comprising verified cases of nonfatal myocardial infarction (Ml), nonfatal stroke, revascularization procedures, and death. The scope of our information is limited to chiropractic and spinal injuries and conditions. To discuss the subject matter, please feel free to ask Dr. Jimenez or contact us at 915-850-0900 .


By Dr. Alex Jimenez


Additional Topics: Wellness


Overall health and wellness are essential towards maintaining the proper mental and physical balance in the body. From eating a balanced nutrition as well as exercising and participating in physical activities, to sleeping a healthy amount of time on a regular basis, following the best health and wellness tips can ultimately help maintain overall well-being. Eating plenty of fruits and vegetables can go a long way towards helping people become healthy.


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